Digital Commons Network^™

Analyzing The Creation And Use Of Abbreviations In Cardiology And Cardiac Imaging Society Guidelines., Christopher R. Green, Rui Zhang, Raymond F. Stainback, Sofia W. Ye, Daniel Forsha, Enrique Garcia-Sayan, Jeffrey C. Hill, Carol Mitchell, Vera H. Rigolin, Vandana Sachdev, Partho P. Sengupta, Vincent L. Sorrell, Jordan B. Strom, Alexander M. Ye, Cynthia C. Taub

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Abbreviation use in clinical and academic cardiology is widespread, yet there are few guidelines regulating the creation and utilization of abbreviations. Inconsistent abbreviations can introduce ambiguity and pose challenges to practice and research.

OBJECTIVES: The authors aimed to analyze how abbreviations are created and utilized in general cardiology and cardiac imaging society guidelines in order to assess whether ambiguities and discrepancies exist between societies.

METHODS: Abbreviation data were collected from 7 national and international societies of general cardiology and cardiac imaging over a 6-year span (2018-2023). Data were linguistically coded for abbreviation type, unique occurrence, meaning or sense count, …

Rapid And Scalable Personalized Aso Screening In Patient-Derived Organoids., John C. Means, Anabel L. Martinez-Bengochea, Daniel A. Louiselle, Jacqelyn Nemechek, John M. Perry, Emily G. Farrow, Tomi Pastinen, Scott T. Younger

Manuscripts, Articles, Book Chapters and Other Papers

Personalized antisense oligonucleotides (ASOs) have achieved positive results in the treatment of rare genetic disease. As clinical sequencing technologies continue to advance, the ability to identify patients with rare disease harbouring pathogenic genetic variants amenable to this therapeutic strategy will probably improve. Here we describe a scalable platform for generating patient-derived cellular models and demonstrate that these personalized models can be used for preclinical evaluation of patient-specific ASOs. We describe protocols for delivery of ASOs to patient-derived organoid models and confirm reversal of disease-associated phenotypes in cardiac organoids derived from a patient with Duchenne muscular dystrophy (DMD) with a structural …

Diagnostic Accuracy Prior To Congenital Heart Defect Surgery: A Multicenter Collaboration., Shobha S. Natarajan, Kasey Chaszczewski, Chris Penney, Steve Ampah, Douglas Ryba, Andrea T. Kennedy, Robert Olsen, Shubhika Srivastava, Matthew J. Campbell, Mya Carney, Carol Prospero, Lisa Elliott, Carlie Brewer, Michael Dimaria, Nitin Madan, Seda Tierney, Meaghan Beattie, Ritu Sachdeva, Joan Lipinski, Kenan W D Stern, Grace Kong, Preeta Dhanantwari, Elena N. Kwon, Hari Rajagopal, Carolyn Taylor, Tammy Churchill, Aura A. Sanchez Mejia, Deidra Abenlah Ansah, Anitha Parthiban, Hasti Sanandajifar, Sowmya Balasubramanian, David A. Parra, Kimberly Crum, Corey Stiver, Aarti H. Bhat, Pei-Ni Jone, Stefani Samples, Kathleen Van't Hof, Curt Degroff, Dalia Lopez-Colon, Meryl S. Cohen

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Echocardiography is the mainstay for diagnosing congenital heart disease (CHD). Diagnostic errors can lead to suboptimal surgical outcomes.

OBJECTIVES: This multicenter pediatric echocardiography collaborative learning initiative explores reasons for diagnostic errors, investigates associations between patient- and center-specific factors and errors, and relays the benefits of a multicenter approach to decrease these errors as a first step to improve CHD surgical outcomes.

METHODS: Participating centers submitted diagnostic evaluations on patients prior to 2-ventricle repair into a central database. We held virtual meetings to revise variables and discuss cases to learn from each other.

RESULTS: Fourteen pediatric echocardiography laboratories entered data …

The Alphaproteobacterial General Stress Response: Investigating Protein Structure, Dynamics, And Regulatory Mechanisms, Danielle Swingle

Dissertations, Theses, and Capstone Projects

Bacteria are relatively simple organisms that face a wide variety of environmental challenges. Their survival is determined by their ability to sense and respond to changes in their surroundings. Alphaproteobacteria commonly accomplish this using the general stress response (GSR). During the first step in this system, a signal is detected by a sensor histidine kinase (HK), modulating autophosphorylation within its kinase domain. HKs involved in the GSR generally belong to the HWE/HisKA2 family, a lesser studied group of HKs with noncanonical features. The signal is propagated when the HK phosphorylates the next protein in the pathway, PhyR. Once activated, PhyR …

The Role Of Secondary And Tertiary Structure In The Cap-Independent Translation Of Fgf-9 And Hif-1-Alpha, Amanda Michelle Whittaker

Dissertations, Theses, and Capstone Projects

Under normoxic conditions, eukaryotes initiate translation of RNA through eIF4E recognition of the 5’ cap. However, under cellular stress, eukaryotic translation must be initiated through a 4E-independent, or “cap-independent” mechanism, involving eukaryotic initiation factor 4G (eIF4G) binding directly to the 5’ untranslated regions (5’ UTR) of the RNA. eIF4G binding then recruits the ribosome to the transcript. While this mechanism is useful for translation of apoptotic transcripts and transcripts involved in cell survival, cap-independent translation is also utilized by oncogenic RNA for tumorigenesis. Previous work by our lab and others has categorized this recruitment and initiation mechanism as either internal-ribosome-entry-site …

Myth, Mayhem, And Pseudo-Democracy: The Role Of Political Myths In Mobilizing Nationalist Populist Movements And Political Extremists, Stephon J. Boatwright

Dissertations, Theses, and Capstone Projects

This body of research analyzes the enduring impact of political myth in nationalist populism and extremist movements. The rise of Western nationalist parties and acts of terror in the early 21st century gave life to this project. The manuscript advances two theories regarding political myths and their relationship to far right radicalism. First, nationalist myths—sprawling political worldviews whose dogmatic tenets are resistant to empirical critique and rational refutation—function as ideological constructs. They fictionalize the causes of events and serve to recruit adherents to authoritarian causes. Myths are continually reworked to address factual inaccuracies, failed predictions, and evolving social developments, while …

A Benjaminian Rumination Of Grasses And Tomatoes In Contemporary Anatolian Film, Ceren Izci

Dissertations, Theses, and Capstone Projects

This thesis interprets the intersection of history, ecology, and politics through two contemporary Anatolian films: Nuri Bilge Ceylan’s About Dry Grasses and Murat Fıratoğlu’s One of These Days When Hemme Dies. We focus on the films’ portrayal of social relations and relationships to other living beings through interpreting the temporal layers and historical tensions present in the plots of the films. We introduce the paper by pondering over the question of whether these films are political. Drawing on Walter Benjamin’s concepts of “first nature” and “second nature”, the first chapter introduces the philosophical framework for understanding the connection between …

The Material Folklore Of Occult Zines, Jacqueline G. Coffey

Dissertations, Theses, and Capstone Projects

This capstone is a paper on and catalog of contemporary occult zines. Through the collecting, arranging, and analyzing of about one hundred zines, I stipulate that these zines draw from the rich and rebellious histories of both the occult and zines. With the dominating influence of multi-industry corporations on our lives, these often independently produced and handmade texts are evidence of the mystical and mysterious forces with which we still grapple. Not only do zines showcase the breadth of spiritual possibility, they can also be used to integrate new metaphysical awareness into mundane reality.

The catalog is also intended to …

Tracing The Sources Of Nitrogen In Submarine Groundwater Discharge And Primary Producers In The Great South Bay Estuary, Nia H. Rene

Dissertations, Theses, and Capstone Projects

The primary aim of this research was to elucidate the impact of submarine groundwater discharge (SGD) and septic effluent on coastal primary producers in the Great South Bay (GSB). The study focused on three main objectives: assessing the impact of precipitation patterns on SGD, tracing nitrogen sources into the GSB, and determining the impact of these nitrogen sources on coastal primary producers. The research revealed that current precipitation patterns significantly influence SGD across different seasons, highlighting the seasonal variability in groundwater discharge and its implications for nutrient loading in coastal waters. A suite of tracers was employed to identify and …

On The Ambiguity Of Wh-Expressions In Thai, Naparat Meechanyakul

Dissertations, Theses, and Capstone Projects

This dissertation deals with an ambiguity problem of wh-indeterminates in Thai. Thai wh-phrases are indeterminates in that their interpretations depend on licensing conditions and structural environments. In this dissertation, observed ambiguous interpretations of object wh-arguments in Thai are described and analyzed through the lens of a phase-based approach under the Minimalist Program. The ambiguity problem concerns the fact that ʔàraj ‘what’ and khraj ‘who’ receive two possible interpretations, namely indefinite/NPI and interrogative, when they appear as an internal argument of serialized verb phrases and under c-commanding negation. Other wh-phrases in the language, namely the locative wh …

À La Poursuite De Céline À New York, Gabriel Maginier

Dissertations, Theses, and Capstone Projects

Louis-Ferdinand Céline n’a cessé de multiplier les allers-retours entre Paris et New York, jusqu’à la veille de la Seconde Guerre mondiale. Le voyage commence dès 1925. Sa première expérience avec la Société des Nations (ancêtre de l’ONU), en tant que “responsable des échanges de médecins spécialistes”, prouve également son bon niveau en anglais. C'est sous l'égide de l’organisation internationale que le Docteur Louis Destouches se voit confier la direction d'une délégation de médecins sud-américains, qui l'amène à traverser toute l'Amérique de Nord. Ce périple de quatre mois le conduit de Cuba à la Louisiane, de New York à Montréal, esquissant …

Modernity And The Promise Of Democracy: A Democratic Reading Of Machiavelli And Hobbes, Gabriel Garber

Dissertations, Theses, and Capstone Projects

A review of the democratic scholarship on Niccolò Machiavelli and Thomas Hobbes reveals a tension between institutional and anti-institutional democratic interpretations. This reflects a knot in democracy itself. Miguel Vatter’s labels this knot ‘form and event’ in his democratic interpretation of Machiavelli. Machiavelli’s theory of form and event comes through an exploration of the tensions between structure, agency, rhetoric, and radical openness in the political realm. For Hobbes, the radically egalitarian state of nature produces one first and final event (the social contract) towards a world of strict form. The democratic interpreters have best noticed the tension between form and …

Visualizing The Rise Of American Women's Soccer, Hoi Wah Tang

Dissertations, Theses, and Capstone Projects

The rise of American women’s soccer is a compelling narrative of determination, talent, and triumph on the global stage. From the inaugural FIFA Women’s World Cup in 1991 to the ongoing dominance of the U.S. Women’s National Team (USWNT), this journey encapsulates not only athletic excellence but also the broader struggles for equality, representation, and respect in sports.

This project aims to bring this story to life by presenting a rich tapestry of data visualizations, timelines, and multimedia elements that showcase key moments, players, and milestones. Through engaging graphics and interactive features, users will explore how the sport evolved, the …

Evidence For Interactive Effects Of Inhibitory And Prospective Intolerance Of Uncertainty And Stimulus-Level Uncertainty On Threat Safety Discrimination Learning, Kyoko Yazaki

Dissertations, Theses, and Capstone Projects

Fear is a fundamental component of human learning, critical for survival, and extensively studied through Pavlovian conditioning paradigms (LeDoux & Pine, 2016). This thesis examines the interplay between stimulus-level uncertainty and individual differences in intolerance of uncertainty (IU) on threat-safety discrimination learning. Using a within-subject design, participants were conditioned to certain (100% reinforcement), uncertain (50% reinforcement), and safety (0% reinforcement) cues through the pairing of colored visual stimuli with aversive electrical shocks. Discrimination learning was assessed using both implicit (SCR) and explicit (self-reported US expectancy estimates and unpleasantness ratings) measures.

The present study (n = 102) replicated previous findings showing …

Chatgpt Didn’T Write This: Evaluating The Impact Of Llms With A Case Study In Grading Cuny Language Immersion Program Student Essays, Benjamin Inbar

Dissertations, Theses, and Capstone Projects

This study evaluates the capabilities and limitations of large language models (LLMs), specifically OpenAI’s ChatGPT-4o, in grading essays from students in the City University of New York’s Language Immersion Program. The program serves English language learners with diverse linguistic and demographic backgrounds, offering intensive language instruction to prepare students for academic success in college. Using a dataset of 30 pre- and post-program essays scored by program instructors and ChatGPT-4o under three paradigms, this research explores the alignment between human and AI-generated scores across five rubric-based competency areas. Findings reveal that ChatGPT-4o aligns moderately with human grading, with the strongest agreement …

Decades Of Division: Analyzing Hate Crimes In The Usa (1991–2022), Sangeeth Sajan Baby

Dissertations, Theses, and Capstone Projects

This project comprehensively analyses hate crime data in the United States, leveraging advanced data analysis and visualization techniques to unmask patterns and insights. By utilizing datasets of criminal offenses reported by law enforcement agencies such as the FBI, this study explores the dynamics of hate crimes across racial, religious, gender, and sexual orientation groups. The analysis reveals key findings, including the disproportionate targeting of African Americans and LGBTQ+ individuals, the prevalence of hate crimes in specific locations like residences and educational institutions, and the consistent patterns of attack types and locations across different racial groups. Analysis of crime data over …

Characterizing Malaria Infections In Caribbean Lizards: Parasite Niche Expansion & Host Response, Sarah J. Pangburn

Dissertations, Theses, and Capstone Projects

Malaria is historically one of the most severe parasitic human diseases and is still responsible for over half a million deaths annually. Plasmodium species, the causative agents of malaria, are often characterized by two hallmark features of their asexual stages: the invasion of vertebrate red blood cells and the presence of hemozoin pigment as a byproduct of host hemoglobin digestion. Despite their evolutionary relatedness to mammalian Plasmodium, wildlife malaria parasites are understudied, leaving their vast genetic diversity to be explored. Lizard-infective malaria parasites, for example, include over 100 species of Plasmodium and present a diverse array of phenotypes, some …

Beauty Comes With A Price: But How Much Is It Worth It, Fabliha Afia

Dissertations, Theses, and Capstone Projects

The global skincare market, valued at 104.24 billion dollars in the year 2022, is very heterogeneous, ranging from prestige brands to more drugstore types. Even when the same key ingredients are present, the latter often sells for much higher due to branding and packaging and the aura of prestige created. This capstone project entitled "Beauty comes with a price: but how much is it worth?" investigates if such higher costs are justified due to superior quality or are driven by non-functional factors. It systematically compared the high-end versus drugstore skincare products in categories like sunscreens, serums, and exfoliants with respect …

Correlations Between Song Popularity And Their Audio Features Using Machine Learning, Rong Chen

Dissertations, Theses, and Capstone Projects

This project is an interactive visual project that explores the relationship between audio features and song popularity on Spotify using machine learning techniques. Through the collection of nearly half a million songs and implementation of seven different machine learning models, including Linear Regression, Random Forest, Decision Trees, and Gradient Boosting, I investigated how audio characteristics correlate with a song's popularity ranking. The project utilized MongoDB for data storage, Spotipy for API integration, and Streamlit with Plotly for visualization. This work provides insights into the practical challenges of large-scale music analysis and the relationship between technical audio characteristics and commercial success, …

Caedmon Records & The Power Of Youth: How Audiobooks Revolutionized Children’S Literature, Faihaa Khan

Dissertations, Theses, and Capstone Projects

The first known spoken-word recording was introduced to the world by Thomas Edison through the invention of the phonograph. Originally intended for a visually impaired audience to read without exertion, the first known recording was a recitation of the English nursery rhyme “Mary Had a Little Lamb" by Edison himself. The inclusion of a children’s nursery rhyme since the genesis of such an invention has become significant in observing the rise and success of the audiobook industry and its direct impact in increasing literacy proficiency in children.

Interactions between children’s literature and the history of the audiobook have been many …

Serotonin Neurons Integrate Gaba And Dopamine Inputs To Regulate Meal Initiation, Kristine M Conde, Hueyzhong Wong, Shuzheng Fang, Yongxiang Li, Meng Yu, Yue Deng, Qingzhuo Liu, Xing Fang, Mengjie Wang, Yuhan Shi, Olivia Z Ginnard, Yuxue Yang, Longlong Tu, Hesong Liu, Hailan Liu, Na Yin, Jonathan C Bean, Junying Han, Megan E Burt, Sanika V Jossy, Yongjie Yang, Qingchun Tong, Benjamin R Arenkiel, Chunmei Wang, Yang He, Yong Xu

Children’s Nutrition Research Center Staff Publications

Obesity is a growing global health epidemic with limited orally administered therapeutics. Serotonin (5-HT) is one neurotransmitter which remains an excellent target for new weight-loss therapies, but a gap remains in understanding the mechanisms involved in 5-HT produced in the dorsal Raphe nucleus (DRN) and its involvement in meal initiation. Using an optogenetic feeding paradigm, we showed that the 5-HTDRN→arcuate nucleus (ARH) circuit plays a role in meal initiation. Incorporating electrophysiology and ChannelRhodopsin-2-Assisted Circuit Mapping, we demonstrated that 5-HTDRN neurons receive inhibitory input partially from GABAergic neurons in the DRN, and the 5-HT response can be enhanced by hunger. Additionally, …

Long-Term Fxa Inhibition Attenuates Thromboinflammation After Acute Myocardial Infarction And Stroke By Platelet Proteome Alteration, Amin Polzin, Marcel Benkhoff, Manuela Thienel, Maike Barcik, Philipp Mourikis, Khrystyna Shchurovska, Carolin Helten, Vincent Ehreiser, Zhang Zhe, Franziska Von Wulffen, Alexander Theiss, Sameera Peri, Sophie Cremer, Samantha Ahlbrecht, Saif Zako, Laura Wildeis, Gabrielle Al-Kassis, Daniel Metzen, Amelie Utz, Hao Hu, Lilian Vornholz, Goran Pavic, Enzo Lüsebrink, Jan Strecker, Steffen Tiedt, Mareike Cramer, Michael Gliem, Tobias Ruck, Sven G Meuth, Tobias Zeus, Christoph Mayr, Herbert B Schiller, Lukas Simon, Steffen Massberg, Malte Kelm, Tobias Petzold

Faculty, Staff and Students Publications

Background: Immediate activated factor (F)X (FXa) inhibition exerts direct antiplatelet effects in the context of arterial thrombosis but little is known about the impact of long-term therapy on platelet function in ischemic cardiovascular diseases.

Objectives: Therefore, we analyzed platelet-derived effects of long-term FXa inhibition in the setting of acute myocardial infarction (AMI) and stroke.

Methods: We evaluated the effect of acute versus chronic FXa inhibition on thromboinflammation following AMI and stroke in mice in vivo. Mechanistically, we identified changes in platelet gene expression and proteome under chronic FXa nonvitamin K antagonist oral anticoagulant treatment and characterized its functional consequence on …

Phosphorus Recovery From Synthetic Stormwater Using Iron- And Slag-Amended Green Infrastructure Soils, Colin B. Wilson, Anthony J. Parolari, Brooke Mayer, Kaushik Venkiteshwaran

Civil and Environmental Engineering Faculty Research and Publications

The demand for phosphorus (P), fueled by the need for fertilizers to increase food production due to the ever-increasing population, is increasing P in the environment and diminishing global reserves of this nonrenewable resource. Stormwater runoff transports land-applied P into surrounding waterbodies. Green infrastructure (GI) soils are being engineered to target P removal from stormwater runoff. This research investigates the potential to recover P from engineered GI soils traditionally developed to remove P, contributing to the circular P economy by considering GI as a source of recoverable P. Batch experiments were conducted to determine the P removal performance of iron- …

Exploring Individual Differences In Amygdala-Mediated Memory Modulation, Martina K Hollearn, Joseph R Manns, Lou T Blanpain, Stephan B Hamann, Kelly Bijanki, Robert E Gross, Daniel L Drane, Justin M Campbell, Krista L Wahlstrom, Griffin F Light, Aydin Tasevac, Phillip Demarest, Peter Brunner, Jon T Willie, Cory S Inman

Faculty, Staff and Students Publications

Amygdala activation by emotional arousal during memory formation can prioritize events for long-term memory. Building upon our prior demonstration that brief electrical stimulation to the human amygdala reliably improved long-term recognition memory for images of neutral objects without eliciting an emotional response, our study aims to explore and describe individual differences and stimulation-related factors in amygdala-mediated memory modulation. Thirty-one patients undergoing intracranial monitoring for intractable epilepsy were shown neutral object images paired with direct amygdala stimulation during encoding with recognition memory tested immediately and one day later. Adding to our prior sample, we found an overall memory enhancement effect without …

Global Marine Flyways Identified For Long-Distance Migrating Seabirds From Tracking Data, Joanne M. Morten, Ana P.B. Carneiro, Martin Beal, Anne Sophie Bonnet-Lebrun, Maria P. Dias, Marie Morgane Rouyer, Autumn Lynn Harrison, Jacob González-Solís, Victoria R. Jones, Virginia A. Garcia Alonso, Michelle Antolos, Javier A. Arata, Christophe Barbraud, Elizabeth A. Bell, Mike Bell, Samhita Bose, Scott Shaffer, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

Aim: To identify the broad-scale oceanic migration routes (‘marine flyways’) used by multiple pelagic, long-distance migratory seabirds based on a global compilation of tracking data. Location: Global. Time Period: 1989–2023. Major Taxa Studied: Seabirds (Families: Phaethontidae, Hydrobatidae, Diomedeidae, Procellariidae, Laridae and Stercorariidae). Methods: We collated a comprehensive global tracking dataset that included the migratory routes of 48 pelagic and long-distance migrating seabird species across the Atlantic, Indian, Pacific and Southern Oceans. We grouped individuals that followed similar routes, independent of species or timings of migration, using a dynamic time warping clustering approach. We visualised the routes of each cluster using …

A Simple, Low-Cost Implant For Reliable Diaphragm Emg Recordings In Awake, Behaving Rats, Taylor C. Holmes, Jesus D. Penaloza-Aponte, Alyssa R. Mickle, Rachel L. Nosacka, Erica A. Dale, Kristi A. Streeter

Physical Therapy Faculty Research and Publications

Breathing is a complex neuromuscular process vital to sustain life. In preclinical animal models, the study of respiratory motor control is primarily accomplished through neurophysiologic recordings and functional measurements of respiratory output. Neurophysiologic recordings that target neural or muscular output via direct nerve recordings or respiratory muscle electromyography (EMG) are commonly collected during anesthetized conditions. While offering tight control of experimental preparations, the use of anesthesia results in respiratory depression, may impact cardiovascular control, eliminates the potential to record volitional nonventilatory behaviors, and can limit translation. Since the diaphragm is a unique muscle which is rhythmically active and difficult to …

Reflections On The Origin Of Linear B, (Part 8); Sign 16 (Looks Like A Human Head) And Its Possible Connection To The Ancient Egyptian God Ptaḥ, Gerald Leonard Cohen

Arts, Languages and Philosophy Faculty Research & Creative Works

This article suggests a rationale for the shape of Linear B sign 16 being that of a human head: The sign likely derives from the ancient Egyptian hieroglyph for ‘face’ (recognized already by Sundwall and Evans) and very possibly honors the ancient Egyptian god Ptah, described as ‘Beautiful of Face.’ Also, remarkably, a total of three Linear B signs may be traceable directly to Ptah, and a fourth one (shared with Osiris) may be connected with him too.

Looking Out For Danger: Theoretical And Empirical Issues In Translating Human Attention Bias Tasks To Assess Animal Affective States, Sarah Kappel, Sarah Collins, Michael Mendl, Carole Fureix

School of Biological and Marine Sciences

Understanding animal emotional (affective) state is highly relevant to various disciplines (e.g., animal welfare, neuroscience, comparative psychology), and has been significantly advanced by translating affect-induced cognitive bias paradigms rooted in human psychology to non-human animal studies. Attention bias (i.e., preferential attention allocation, AB) tests are increasingly used as more practical substitutes to commonly used judgement bias tests. Yet, evidence that AB reflects affective valence in animals is still limited. We review in-depth the concept of attention and AB described in humans and discuss utilising human-derived AB paradigms for measuring animal affective states. We describe key concepts and functions of attention …

High Shear Stress Reduces Erg Causing Endothelial-Mesenchymal Transition And Pulmonary Arterial Hypertension, Tsutomu Shinohara, Jan-Renier Moonen, Yoon Hong Chun, Yannick C. Lee-Yow, Kenichi Okamura, Jason M. Szafron, Jordan Kaplan, Aiqin Cao, Lingli Wang, Weiguang Yang

Mechanical Engineering Faculty Publications

Background: Computational modeling indicated that pathological high shear stress (HSS; 100 dyn/cm2) is generated in pulmonary arteries (PAs; 100-500 µm) in congenital heart defects causing PA hypertension (PAH) and in idiopathic PAH with occlusive vascular remodeling. Endothelial-to-mesenchymal transition (EndMT) is a feature of PAH. We hypothesize that HSS induces EndMT, contributing to the initiation and progression of PAH.

Methods: We used the Ibidi perfusion system to determine whether HSS applied to human PA endothelial cells (ECs) induces EndMT when compared with physiological laminar shear stress (15 dyn/cm2). The mechanism was investigated and targeted to prevent PAH in a mouse with …

Case (Cemiplimab-Rwlc Survivorship And Epidemiology): A Study In Advanced Basal Cell Carcinoma, Guilherme Rabinowits

All Publications

Patients diagnosed with metastatic basal cell carcinoma (BCC) have a poor prognosis. The current standard of care for adults with locally advanced or metastatic BCC who are not candidates for surgery or radiation therapy is treatment with hedgehog pathway inhibitors (HHIs). For patients who progress while on this therapy, further treatment options are limited. There is also a need for real-world clinical practice data on the clinical characteristics, management, disease progression, and survivorship of these patients. The ongoing CemiplimAb-rwlc Survivorship and Epidemiology (CASE) study is a phase IV, multicenter, prospective, noninterventional survivorship and epidemiology cohort study evaluating the effectiveness and …