Digital Commons Network^™

Modeling The Kinetics Of Interorgan Arginine Metabolism During Bacterial Sepsis In Swine, Caitlin Vonderohe, Douglas Burrin

Faculty, Staff and Students Publications

No abstract provided.

Understanding And Implementing Fashion Sustainability: An Academic Course, Paige M. Baldwin

Theses

This project outlined a fashion sustainability course meant to be taught at a degree-awarding educational institution. The course explores the environmental, social, and economic impacts of the fashion industry. Students learn about sustainable practices, materials, and design principles. Students also study consumer behavior, supply chain management, and government policies related to sustainable fashion. The literature and research looked at the current fashion industry landscape and the sustainability issues that are being addressed, the current educational landscape of fashion programs in the United States of America, and the current literature regarding building an effective curriculum in the 21st century.

Fragility And Strength In Times Of War: A Series Of Embroidered Watercolors, Alisha B. Whitman

Theses

This final project report follows the production of a series of embroidered watercolors that explore how war disrupts and can destroy the values which people manage to somehow both hold dear and take for granted. These values, such as peace and freedom, are fragile, and yet they can provide great strength in dark times. This dichotomy is explored through this body of work using the materials of painted paper and thread as symbols of both fragility and strength. Choosing to work with materials and methods historically seen as feminine work add additional meaning to that symbolism. Additionally, Jewish iconography and …

Physicians' Perceptions Of Barriers And Facilitators To The Improvement Of Healthcare Equity For Children Hospitalized With Traumatic Brain Injury: Preliminary Findings From A Pilot Multicenter Pediatric Trauma Study From The United States, Chelsea D Hicks, Heather Barnett, Jennifer Shi, Julia Velonjara, Mauricio A Escobar, Darci Evans, John Fisher, Arnett Klugh Iii, Katrina M Morgan, Morgan K Richards, Sarah Risen, Courtney Robertson, Irim Salik, Dennis W Simon, Arul S Thirumoorthi, Deidre L Wyrick, Bryan J Weiner, Theresa J Hoeft, Monica S Vavilala

Faculty, Staff and Students Publications

Background and objective: Disparities in outcomes for pediatric patients with traumatic brain injuries (TBI) in rural populations and for racial and ethnic minority groups have been documented. In light of this, we examined physician champions' perceptions of healthcare equity for hospitalized children with TBI.

Methods: We surveyed 10 physician TBI champions at 10 US pediatric trauma centers (PTCs) regarding organizational characteristics, barriers, and facilitators (domains and specific) in terms of improving healthcare equity, and priorities to redress inequities.

Results: Level I center TBI champions reported more pediatric beds and higher staffing-to-patient ratios while Level II TBI champions reported more pediatric …

Use Of Robust Norming To Create A Sensitive Cognitive Summary Score In De Novo Parkinson's Disease: An Illustrative Example, Daniel Weintraub, Michael C Brumm, Ryan Kurth, Michele K York

Faculty, Staff and Students Publications

Background: Cognitive impairment is common at all stages of Parkinson's disease (PD), but there is no consensus on which neuropsychological tests to use or how to interpret cognitive battery results. A cognitive summary score (CSS) combines the richness of a neuropsychological battery with the simplicity of a single score.

Objective: The objective of this study was to determine whether a CSS created using robust norming can detect early cognitive deficits in de novo, untreated PD.

Methods: Baseline cognitive data from PD participants and healthy control participants (HCs) in the Parkinson's Progression Markers Initiative were used to (1) create a robust …

Two-Year Feasibility And Safety Of Open-Label Autologous Peripheral Nerve Tissue Implantation During Deep Brain Stimulation In Patients With Parkinson's Disease, Jorge E. Quintero, Monica J. Chau, John T. Slevin, Lisa Koehl, Julie A. Gurwell, Elizabeth Wallace, Richard J. Kryscio, Riham El Khouli, Amelia J. Anderson-Mooney, Frederick A. Schmitt, Greg A. Gerhardt, Craig G. Van Horne

Psychology Faculty Publications

Background: Motor dysfunction in Parkinson's disease (PD) is characterized by a loss of functioning neurons in the substantia nigra. Two options exist when encountering damaged neurons: replace or support. We implemented a strategy of using autologous peripheral nerve tissue, in a reparative state, to provide a collection of neurorestorative support to unhealthy neurons with the goal of modifying the motor progression of PD. Objective: Report on two-year compliance feasibility, safety, and clinical experience of combining this delivery at the time of deep brain stimulation (DBS) surgery. Methods: Participants with PD undergoing open-label peripheral nerve tissue implantation to the substantia nigra …

A Wave-Optics Bsdf For Correlated Scatterers, Ruomai Yang

Dartmouth College Master’s Theses

In this project, we present a wave optics bidirectional scattering distribution function(BSDF) for the material with a collection of scatterers, such as certain fabrics with pores or foggy glass, where the corona effect can be observed under strong light sources. This effect arises from the diffraction of individual scatterers and the interference between them. To describe this effect, we treat each scatterer as an aperture to calculate diffraction, while using a pair correlation function to represent their spatial relationships and calculate the interference. This two-level decomposition allows us to derive a BSDF that can control both the individual diffraction function …

Nebraska Ornithologists’ Union Treasurer’S Report, December 31, 2024, Jan Johnson

Nebraska Bird Review

No abstract provided.

Liability Considerations For Marine Carbon Dioxide Removal Projects In U.S. Waters, Korey Silverman-Roati, Martin Lockman, Romany M. Webb

Sabin Center for Climate Change Law

Scientists have identified a number of land- and ocean-based carbon dioxide removal (“CDR”) approaches. Ocean-based approaches, also known as marine CDR, hold great potential for uptake and sequestration of carbon dioxide. However, controlled field trials in the ocean are needed to better understand the efficacy and impacts of several marine CDR approaches. Legal considerations will have a major bearing on whether, when, where, and how such field research goes forward. Previous studies have analyzed the potential international and domestic legal framework applicable to marine CDR research and subsequent deployment (if that is ultimately deemed appropriate). However, relatively little research has …

Microbial Communities Associated With Endangered West Texas Springsnails And Their Potential Roles In Conservation, Russell L. Minton, Kathryn E. Perez

School of Integrative Biological & Chemical Sciences Faculty Publications

Desert springs are one of the most threatened ecosystems globally. Those in Southwestern North America support high numbers of threatened and endemic species. Human activities present the greatest threats to springs and the organisms they support. Freshwater snails in the genera Pyrgulopsis and Tryonia are two groups of such organisms, representing diverse and threatened groups of springsnails in the Southwestern United States. Desert springs also harbour unique microbial diversity that faces similar threats from water usage and freshwater habitat degradation. Understanding springsnails and the bacteria they host represent potential exemplars for interdisciplinary conservation efforts. We studied the bacterial communities associated …

Effects Of Antidiabetic Drugs On The Level Of Serum Uric Acid In Patients Who Have Type 2 Diabetes, Gang Wang, Guixia Wang

Saudi Medical Journal

ABSTRACT Hyperuricemia and type 2 diabetes mellitus (T2DM) are interconnected, in that each disorder increases risk for the other. Some antidiabetic drugs may decrease the level of serum uric acid (SUA). This narrative review describes the effects of multiple antidiabetic drugs on the SUA level and their possible mechanisms of action in patients with T2DM. The results showed that sodium glucose contransporter-2 inhibitors (SGLT2is), thiazolidinediones, metformin, and linagliptin decreased the SUA; insulin, sitagliptin, and alogliptin increased the SUA; and glucagon-like peptide-1 receptor agonists (GLP-1 RAs), sulfonylureas, and alpha-glucosidase inhibitors had little effect on the SUA. Sodium glucose contransporter-2 inhibitors appeared …

Impact Of Dietary Intake On Brain Choline Levels: A 3 Tesla Magnetic Resonance Spectroscopy Study, Halima Hawesa, Mayar Alghumaiz, Renad Alghamdi, Nourah Alrabiah, Bayader Alfaifi, Hind Allam, Mahasin Gamalalddin, Haya Alshegri, Mansour Shanawani

Saudi Medical Journal

Objectives: To investigate the relationship between dietary choices and brain choline (Cho) levels using magnetic resonance spectroscopy (MRS). Methods: A total of 88 female students from the radiology department at King Abdullah bin Abdulaziz University Hospital, Riyadh, Saudi Arabia, participated in this study. Brain total choline (tCho) levels were estimated using MRS single volume sequence at a 3 Tesla field, with an echo time of 30 ms, repetition time of 2000 ms, voxel size of 15x15x15 mm, and water suppression bandwidth of 50 Hz. Participants’ food consumption habits were assessed using a dietary questionnaire to quantify the amount of protein …

Diet-Enhanced Lrg1 Expression Promotes Insulin Hypersecretion And Er Stress In Pancreatic Beta Cells, Desirae D. Morales, Jiyoon Ryu, Cong Wei, Jason T. Hadley, Juli Bai, Juan C. Lopez-Alvarenga, Srinivas Mummidi, Ravi Duggirala, Jane L. Lynch, Feng Liu, Lily Q. Dong

School of Medicine Publications

Aims/hypothesis: Upregulation of serum leucine-rich α-2-glycoprotein 1 (LRG1) has been implicated in diet-induced obesity and metabolic disorders. However, its specific hormonal actions remain unclear. This study aimed to determine whether diet-enhanced serum LRG1 levels promote hyperinsulinaemia by directly stimulating insulin secretion from pancreatic beta cells.

Methods: Human serum samples were obtained from individuals (both male and female) undergoing plastic surgery. Male C57BL/6 wild-type and Lrg1 whole-body knockout (Lrg1KO) mice were fed a 45% high-fat diet, with serum samples collected every 2 weeks to monitor LRG1 and insulin levels throughout diet-induced obesity. MIN6 beta cells were used to investigate the effects …

Leveraging Artificial Intelligence And Machine Learning To Accelerate Discovery Of Disease-Modifying Therapies In Type 1 Diabetes., Melanie R. Shapiro, Erin M. Tallon, Matthew E. Brown, Amanda L. Posgai, Mark A. Clements, Todd M. Brusko

Manuscripts, Articles, Book Chapters and Other Papers

Progress in developing therapies for the maintenance of endogenous insulin secretion in, or the prevention of, type 1 diabetes has been hindered by limited animal models, the length and cost of clinical trials, difficulties in identifying individuals who will progress faster to a clinical diagnosis of type 1 diabetes, and heterogeneous clinical responses in intervention trials. Classic placebo-controlled intervention trials often include monotherapies, broad participant populations and extended follow-up periods focused on clinical endpoints. While this approach remains the 'gold standard' of clinical research, efforts are underway to implement new approaches harnessing the power of artificial intelligence and machine learning …

Massive Gastroduodenal Trichobezoar Removed With Hydrodissection: A Case Report, Seth Saylors, Cory Nonnemacher, Irene Isabel P. Lim

Manuscripts, Articles, Book Chapters and Other Papers

Introduction

Case presentation

Biochar-Derived Photocatalysts For Pharmaceutical Waste Removal, A Sustainable Approach To Water Purification, Maryam Zahid, Zia Ul Haq Khan, Jingyu Sun, Nawshad Muhammad, Sana Sabahat, Noor Samad Shah, Jibran Iqbal

All Works

In the past few years, the utilization of pharmaceutical compounds has considerably increased to treat human and animal diseases. The pharmaceutical waste, processed or unprocessed, is being released into water systems. This contamination leads to the death of millions of people across the globe annually. Tailored treatment procedures are effectively employed to remove these compounds. However, many of these techniques suffer from high-cost apparatus, generation of secondary pollutants, and sludge etc. Conversely, adsorption combined with photocatalysis is an alternative, economical and efficient method for water remediation. This review delves deeper into the synthesis protocols of biochar derived photocatalysts and investigates …

Protective Effects Of Nerolidol On Thrombotic Events, Systemic Inflammation, Oxidative Stress, And Dna Damage Following Pulmonary Exposure To Diesel Exhaust Particles, Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Alreem Alderei, Maha Alfalahi, Shamma Alhefeiti, Dana Alnaqbi, Salama Alshamsi, Abderrahim Nemmar

All Works

Background/Objectives: Inhalation of environmental particulate air pollution has been reported to cause pulmonary and systemic events including coagulation disturbances, systemic inflammation, and oxidative stress. Nerolidol, a naturally occurring sesquiterpene alcohol, has effective antioxidant and anti-inflammatory effects. Hence, the aim in the present investigation was to evaluate the potential ameliorative effects of nerolidol on the coagulation and systemic actions induced by pulmonary exposure to diesel exhaust particles (DEPs). Methods: Nerolidol (100 mg/kg) was given to mice by oral gavage one hour before the intratracheal instillation of DEPs (0.5 mg/kg), and 24 h later various markers of coagulation and systemic toxicity were …

Standardizing Canine Breed Data In Veterinary Records Is Challenging, But Computer Vision Offers An Alternative Perspective On Breed Assignment, Glenvelis Perez, Yixuan He, Zihan Lyu, Yilin Chen, Nicholas Howe, Halie M. Rando

Computer Science: Faculty Publications

Dog breed is fundamental health information, especially in the context of breed-linked diseases. The standard-ization of breed terminology across health records is necessary to leverage the big data revolution for veterinary research. Breed can also inform clinical decision making. However, client-reported breeds vary in their reliability depending on how breed was determined. Surprisingly, research in computer science reports that AI can assign breed to dogs with over 90% accuracy from a photograph. Here, we explore the extent to which current research in AI is relevant to breed assignment or validation in veterinary contexts. This review provides a primer on approaches …

Imageinthat: Manipulating Images To Convey User Instructions To Robots, Karthik Mahadevan, Blaine Lewis, Jiannan Li, Bilge Mutlu, Anthony Tang, Tovi Grossman

Research Collection School Of Computing and Information Systems

Foundation models are rapidly improving the capability of robots in performing everyday tasks autonomously such as meal preparation, yet robots will still need to be instructed by humans due to model performance, the difficulty of capturing user preferences, and the need for user agency. Robots can be instructed using various methods---natural language conveys immediate instructions but can be abstract or ambiguous, whereas end-user programming supports longer-horizon tasks but interfaces face difficulties in capturing user intent. In this work, we propose using direct manipulation of images as an alternative paradigm to instruct robots, and introduce a specific instantiation called ImageInThat which …

Adversarial Attacks On Event-Based Pedestrian Detectors: A Physical Approach, Guixu Lin, Muyao Niu, Qingtian Zhu, Zhengwei Yin, Zhuoxiao Li, Shengfeng He, Yinqiang Zheng

Research Collection School Of Computing and Information Systems

Event cameras, known for their low latency and high dynamic range, show great potential in pedestrian detection applications. However, while recent research has primarily focused on improving detection accuracy, the robustness of event-based visual models against physical adversarial attacks has received limited attention. For example, adversarial physical objects, such as specific clothing patterns or accessories, can exploit inherent vulnerabilities in these systems, leading to misdetections or misclassifications. This study is the first to explore physical adversarial attacks on event-driven pedestrian detectors, specifically investigating whether certain clothing patterns worn by pedestrians can cause these detectors to fail, effectively rendering them unable …

Learning To Identify Seen, Unseen And Unknown In The Open World: A Practical Setting For Zero-Shot Learning, Sethupathy Parameswaran, Yuan Fang, Chandan Gautam, Savitha Ramasamy, Xiaoli Li

Research Collection School Of Computing and Information Systems

As vision-language models advance, addressing the Zero-Shot Learning (ZSL) problem in the open world becomes increasingly crucial. Specifically, a robust model must handle three types of samples during inference: seen classes with visual and semantic information provided in training, unseen classes with only the semantic information in training, and unknown samples with no prior information from training. Existing methods either handle seen and unseen classes together (ZSL) or seen and unknown classes (known as Open-Set Recognition, OSR). However, none addresses the simultaneous handling of all three, which we term Open-Set Zero-Shot Learning (OZSL). To address this problem, we propose a …

A Comparison Of Training Procedures On The Emergence Of Intraverbal-Tacts, Mary Halbur, Tiffany Kodak, Jessi Reidy

Psychology Faculty Research and Publications

Vocal exchanges are often comprised of responses under multiple sources of stimulus control. For example, a picture may contain multiple components, and an instructor may ask a learner to respond differentially to questions about the picture (e.g., “who,” “what,” “where,” “color,” “number,” “shape”). The format of teaching may affect the development of verbal behavior under multiple sources of stimulus control. Therefore, the present investigation compared teaching stimuli in isolation to teaching with compound stimuli on the emergence of verbal behavior to evaluate methods that assist with correctly answering questions about compound stimuli. This study used a translational model with undergraduate …

Computational Model Of Coarctation Of The Aorta In Rabbits Suggests Persistent Ascending Aortic Remodeling Post-Correction, Ashley A. Hiebing, Matthew A. Culver, John F. Ladisa, Colleen M. Witzenburg

Biomedical Engineering Faculty Research and Publications

Coarctation of the aorta (CoA) is a common congenital cardiovascular lesion that presents as a localized narrowing of the proximal descending aorta. While improvements in surgical and catheter-based techniques have increased short-term survival, there is a high long-term risk of hypertension and a reduced average lifespan despite correction. Computational models can be used to estimate aortic remodeling and peripheral vascular compensation, potentially serving as key tools in developing a mechanistic understanding of the interplay between pre-treatment dynamics, post-treatment recovery, and long-term hypertension risk. In this study, we developed a lumped-parameter model of the heart and circulation to simulate CoA. After …

Impact Of Mass Drug Administration With Ivermectin, Diethylcarbamazine, And Albendazole For Lymphatic Filariasis On Hookworm And Strongyloides Stercoralis Infections In Papua New Guinea, Jannet A. Tobon Ramos, Tobias Maure, Lenore Carias, Daphne Lew, Charles Goss, Anna Samuel, Livingstone Tavul, Peter U. Fischer, Gary J. Weil, Moses Laman, Leanne J. Robinson, William Pomat, Christopher L. King

2020-Current year OA Pubs

BACKGROUND: Persons with lymphatic filariasis (LF) are often co-infected with soil-transmitted helminths. A single co-administered dose of ivermectin/diethylcarbamazine/albendazole (IDA) is recommended by WHO for mass drug administration (MDA) for LF instead of diethylcarbamazine/albendazole (DA) in Papua New Guinea (PNG). We compared the effectiveness of a single round of MDA with IDA or DA on hookworm and strongyloidiasis in PNG.

METHODOLOGY/PRINCIPAL FINDINGS: This study was conducted as part of a cluster randomized trial of MDA with IDA versus DA for LF in individuals willing to provide stool and blood samples at baseline and 12 months after MDA. Participants from 23 villages …

Spatial Proteomics Of Onchocerca Volvulus With Pleomorphic Neoplasms Shows Local And Systemic Dysregulation Of Protein Expression, Lucia S. Di Maggio, Kerstin Fischer, Bruce A. Rosa, Devyn Yates, Byoung-Kyu Cho, Jessica Lukowski, Antonia Zamacona Calderon, Minsoo Son, Young Ah Goo, Nicholas O. Opoku, Gary J. Weil, Makedonka Mitreva, Peter U. Fischer

2020-Current year OA Pubs

Onchocerca volvulus is the agent of onchocerciasis (river blindness) and targeted by WHO for elimination though mass drug administration with ivermectin. A small percentage of adult female worms develop pleomorphic neoplasms (PN) which occur more frequently after ivermectin treatment. Worms with PN have a lower life expectancy and improved understanding of proteins expressed in PN and their impact on different tissues could help elucidate the mechanisms of macrofilaricidal activity of ivermectin. Within paraffin embedded nodules removed after ivermectin treatment, we detected 24 (5.6%) O. volvulus females with PN. To assess the protein inventory of the PN and identify proteins potentially …

Thalamic Deep Brain Stimulation Improves Movement In A Cerebellar Model Of Lesion-Based Status Dystonicus, Megan X Nguyen, Amanda M Brown, Tao Lin, Roy V Sillitoe, Jason S Gill

Faculty, Staff and Students Publications

Dystonia is the third most common movement disorder and an incapacitating co-morbidity in a variety of neurologic conditions. Dystonia can be caused by genetic, degenerative, idiopathic, and acquired etiologies, which are hypothesized to converge on a "dystonia network" consisting of the basal ganglia, thalamus, cerebellum, and cerebral cortex. In acquired dystonia, focal lesions to subcortical network regions lead to dystonia that can be difficult to manage with canonical treatments, including deep brain stimulation (DBS). While studies in animal models have begun to parse the contribution of individual nodes in the dystonia network, how acquired injury to the cerebellar outflow tracts …

Endothelial Cell Piezo1 Promotes Vascular Smooth Muscle Cell Differentiation On Large Arteries, Javier Abello, Ying Yin, Yonghui Zhao, Josh Maurer, Jihui Lee, Cherokee Bodell, Jahmiera Richee, Zarek Burton, Megan E Goeckel, Michelle Lin, Carmen M Halabi, Rajan Sah, Amber N Stratman, Et Al.

2020-Current year OA Pubs

Vascular stabilization is a mechanosensitive process, in part driven by blood flow. Here, we demonstrate the involvement of the mechanosensitive ion channel, Piezo1, in promoting arterial accumulation of vascular smooth muscle cells (vSMCs) during zebrafish development. Using a series of small molecule antagonists or agonists to temporally regulate Piezo1 activity, we identified a role for the Piezo1 channel in regulating klf2a, a blood flow responsive transcription factor, expression levels and altered targeting of vSMCs between arteries and veins. Increasing Piezo1 activity suppressed klf2a and increased vSMC association with the cardinal vein, while inhibition of Piezo1 activity increased klf2a levels and …

Rest And Rinse: Sleeping Rhythms Drive Brain Detox, Leon C D Smyth, Benjamin A Plog, Jonathan Kipnis

2020-Current year OA Pubs

Sleep is a major driver of waste clearance from the brain, but the mechanisms underpinning brain cleansing during sleep, which are also important for immunological functions, are poorly understood. Recent mouse work by Hauglund et al. shows how oscillatory surges in norepinephrine (NE) during sleep drive vascular pulsation and cerebrospinal fluid (CSF) movement to cleanse the brain.

Altered Thermal Preference By Preoptic Estrogen Receptor Alpha Neurons In Postpartum Females, Nan Zhang, Meng Yu, Qianru Zhao, Bing Feng, Yue Deng, Jonathan C Bean, Qingzhuo Liu, Benjamin P Eappen, Yang He, Kristine M Conde, Hailan Liu, Yongjie Yang, Longlong Tu, Mengjie Wang, Yongxiang Li, Na Yin, Hesong Liu, Junying Han, Darah Ave Threat, Nathan Xu, Taylor Smiley, Pingwen Xu, Lulu Chen, Tianshu Zeng, Yanlin He, Chunmei Wang

Faculty, Staff and Students Publications

OBJECTIVE: This study aims to investigate how reproductive experience (RE) alters thermal preference and thermoregulation in female mice, with a focus on estrogen receptor alpha (ERα)-expressing neurons in the preoptic area (POA).

METHODS: Thermal preference and body temperature were measured in female mice with and without RE, and virgin female mice with selective deletion of ERα from the POA (ERα

RESULTS: We showed that female mice prefer a cooler environment starting from late pregnancy and persisting long term postpartum. Female mice with RE (>4 weeks post-weaning) displayed lower body temperature and a lower thermal preferred temperature, and lost preference …

Musculoskeletal Injury In Australian Infantry Personnel: A Cross-Sectional Study To Understand Prevention Priorities, Joanne Stannard, Caroline Finch, Paula Dabovich, Lauren Fortington

Research outputs 2022 to 2026

Introduction: Musculoskeletal injury patterns are under-investigated in the Royal Australian Infantry Corps. Subsequently, more evidence is needed to support injury prevention processes in this population. One difficulty in collecting injury information to monitor injury patterns within combat populations accurately is known injury concealment behaviors in such populations. This study aims to examine musculoskeletal injury epidemiology within Australian infantry battalions using a tailored approach to mitigate reporting avoidance. Materials and Methods: A cross-sectional study using an anonymous online survey captured musculoskeletal injury information directly from personnel serving within 2 Australian infantry battalions. The survey requested information on participants’ injury frequency in …