Digital Commons Network^™

Exploring The Therapeutic Potential Of Trigonella Foenum-Graecum Extract-Loaded Transferosomal Gel In Freund's Complete Adjuvant-Induced Rat Models., Vandana Singh Ms., Hema Arya Ms., Bhavana Singh Dr., Koushal Dhamija Mr., Preeti Singh Dr., Gautam Kumar Dr.

Chulalongkorn Medical Journal

Abstract:

Background: Rheumatoid arthritis (RA) is a debilitating autoimmune disorder characterized by inflammation and joint damage.

Objective: This study aimed to evaluate the antiarthritic activity of Trigonella foenum-graecum (TFG) Transferosomal gel in a Freund’s adjuvant-induced arthritic rat model and compare it with Diclofenac gel, a standard anti-inflammatory drug.

Methods: Arthritis was induced in rats by injecting a 0.1 mL (1mg/ml) CFA suspension into the left hind foot in the subplantar region, allowing them to develop arthritis for 21 days.

Results: Arthritis induction led to a significant increase in paw volume, indicative of inflammation. Treatment with both TFG-transferosomal gel and Diclofenac …

The Role Of Genetics In Human Oral Health: A Systematic-Narrative Review, Anita Joy-Thomas, Zarna Lalwani, Leticia Guajardo, John Valenza, Walid D Fakhouri

Faculty, Staff and Student Publications

Background/Objectives: An individual's genetic makeup influences their organ development, orofacial structures, and overall health. Though many studies have been conducted to determine the inheritance of oral diseases and conditions, there is a lack of comprehensive research classifying these disorders based on the genetic and environmental etiology.

Methods: This systematic review aimed to analyze the existing body of literature using the PubMed and Cochrane databases and answer the following question: "What evidence exists supporting the role of genetic factors in oral conditions?" This systematic-narrative review methodically categorizes oral diseases and conditions based on their genetic or environmental linkages. Each …

Cracking The Code Of Hbv Persistence: Cutting-Edge Approaches To Targeting Cccdna In Chronic Hepatitis B With Or Without Pyogenic Liver Abscesses, Umar Saeed, Zahra Zahid Piracha, Mahmood Khan, Muhammad Nouman Tariq, Syed Shahan Gilani, Muhammad Raza, Rakshana Munuswamy, Naveen Bose, Dilber Uzun Ozsahin, Ilker Özşahin, Surya M. Nauli

Pharmacy Faculty Articles and Research

Chronic Hepatitis B Virus (HBV) infection remains a formidable global health challenge, driving severe liver complications such as hepatocellular carcinoma (HCC) and pyogenic liver abscesses (PLA). At the core of HBV persistence lies covalently closed circular DNA (cccDNA), a viral reservoir that fuels ongoing infection despite antiviral treatments. This review highlights molecular mechanisms governing cccDNA formation, maintenance, and clearance, spotlighting innovative therapeutic strategies to disrupt this key viral element. We explore cutting-edge approaches, including epigenetic modulation to silence cccDNA, RNA interference (RNAi) for viral RNA degradation, and CRISPR/Cas genome editing to excise cccDNA directly. Additionally, emerging antiviral therapies and immunotherapies, …

Books And Media

Appalachia

Reviews of: A Light Through the Cracks: A Climber's Story, by Beth Rodden; Blood Sweat Tears, edited by Christine Reed; Pack Light: A Journey to Find Myself, by Shilletha Curtis; Alpine Rising: Sherpas, Baltis, and the Triumph of Local Climbers in the Greater Ranges, by Bernadette McDonald; Headstrap: Legends and Lore From the Climbing Sherpas of Darjeeling, by Nandini Purandare and Deepa Balsavar; Tramping Monadnock! New Discoveries with Henry David Thoreau, by Robert M. Young; Ghosts of Glencoe, by Chuck Schwerin; The Lifer: Rock Climbing Adventures in the Gunks and Beyond, by …

Research

Appalachia

The seasonal snowpack’s decline is affecting plants and animals.

Last Hike On Mount Monadnock: Friends Confront Time And Mortality, Eric D. Lehman

Appalachia

Two friends push up the southern New Hampshire peak, sensing but not knowing that it will be the last time for one of them.

Rotors, Not Propellers: A Tribute To A Dedicated Helicopter Pilot, Sally Manikian

Appalachia

A tribute to Carl J. Svenson, a pilot who for three decades flew supplies to huts and shelter sites for the Appalachian Mountain Club before his death in a crash in Croyden, New Hampshire, in October 2023.

Mountain Ninjas: Today's Motorized Beasts Of Burden, Justin Preisendorfer

Appalachia

Motorized equipment like snowcats and helicopters have become critical tools for effective recreation management in the modern era in the White Mountain National Forest of New Hampshire.

Flight Lessons: Drones Find Their Way As Search-And-Rescue Tools, Sandy Stott

Appalachia

Since 2018, New Hampshire Fish & Game has begun using drones to search for lost and injured hikers in the White Mountains, complementing ground searches, trained dogs, and helicopters.

Appalachia Winter/Spring 2025: Complete Issue

Appalachia

Winter/Spring 2025 - Volume LXXVI, Number 1 - Issue #259. The Humanity of Machines: Stories of drones, helicopters, and snowcats in the mountains.

The Principle Of Sustainable Development In International Investment Law: A Study From Vietnamese Perspective, Long Tran Thang, Anh Le Tram Pham

Indonesia Law Review

International investment significantly contributes to economic development by fostering hunger eradication, poverty reduction, job creation, and the introduction of new technologies and services. However, it also presents challenges, including resource degradation, environmental decline, waste generation, and human rights violations. This article emphasizes integrating sustainable development principles into international investment law to balance investor and host country interests while safeguarding the environment and human rights for long-term sustainability. In Vietnam, a nation increasingly integrated into the global economy, legal frameworks stipulate sustainable development principles for foreign-invested projects, aligning with international standards to protect the environment and people alongside economic and social …

Fighting Instinct: The Brain, Emotions And Decision-Making In The Water, Jill Nash, Sam Hills

International Journal of Aquatic Research and Education

This conceptual paper explores the complex interplay among the human brain, emotions, and decision-making processes, particularly in aquatic environments. Integrating insights from neuroscience, psychology, and behavioural economics, we investigate how instinctual responses and emotional states influence our decisions during water-related activities. By analysing both biological and psychological factors, the paper aims to illuminate the intricacies of human behaviour in various aquatic settings and highlights significant gaps in the research on emotional decision-making that warrant further investigation. Additionally, the paper suggests interventions, including plausible communication strategies, to mitigate the impact of instinctual responses and improve safety and decision-making efficiency.

Prison Foodways In “Orange Is The New Black”, A. E. Stearns, Morgan Wilson, Mckenzie Richard

Qualitative Criminology (QC)

"The current study adds to the literature on prison foodways and media studies by exploring the role of prison food on the show Orange is the New Black (OITNB). Specifically, this project aimed to better understand the nature of televised incarceration experiences through the way in which incarcerated characters interacted with food in the scenes. Through an analysis of 601 food-related scenes in OITNB, findings suggest: 1) food is a vehicle for additional layers of institutional control of captive bodies, 2) food plays myriad non-food roles such as medicine, a transactional medium, a vehicle for contraband, and even sexual pleasure, …

A Satellite Cell-Dependent Epigenetic Fingerprint In Skeletal Muscle Identity Genes After Lifelong Physical Activity, Kevin A. Murach, Davis A. Englund, Toby L. Chambers, Cory M. Dungan, Hunter L. Porter, Jonathan D. Wren, Willard M. Freeman, Esther E. Dupont-Versteegden, Yuan Wen

Physiology Faculty Publications

Satellite cells comprise a small proportion of mononuclear cells in adult skeletal muscle. Despite their relative rarity, satellite cells have critical functions in muscle adaptation, particularly during prolonged exercise training. The mechanisms by which satellite cells mediate skeletal muscle responsiveness to physical activity throughout the lifespan are still being defined, but epigenetic regulation may play a role. To explore this possibility, we analyzed global DNA methylation patterns in muscle tissue from female mice that engaged in lifelong voluntary unweighted wheel running with or without satellite cells. Satellite cells were ablated in adulthood using the tamoxifen-inducible Pax7-DTA model. Compared to sedentary …

"Nobody Gives A Damn If You Don't Know The Rules": Poverty, Strain, And Crime, Chrystina Y. Hoffman, Dana R. Dillard, Erin King, Angela Blackburn

Qualitative Criminology (QC)

"General strain theory posits that individuals commit crimes when they experience negative emotions following various sources of strain. One such source of strain is poverty. In this study, researchers use focus group data and apply a general strain framework to analyze criminal offending during the Missouri Community Action Network's Poverty Simulation© (2022) at a regional comprehensive university in the Southeast region of the United States. A total of 99 undergraduate and graduate students participated in the focus groups at the end of the simulation. Findings support Agnew’s (1992) theory with examples of sources of strain stemming from poverty leading to …

Primary Source Analysis: Using Digitized Time-Motion Study Films In The Undergraduate Business Classroom To Build Primary Source Literacy, Annette Bochenek, Renusree Varma Mudduluru

Libraries Faculty and Staff Scholarship and Research

This paper details a study conducted in the context of a large Midwestern university’s undergraduate business class, employing the ACRL RBMS-SAA Guidelines for Primary Source Literacy in a guided in-class activity using digitized primary sources. Students participated in an introductory lesson pertaining to primary sources and their connection to business, followed by viewing and analyzing digitized clips from Frank and Lillian Gilbreth’s time-motion studies. In addition, they completed a reflective discussion board post, illuminating their connections to the ACRL RBMS-SAA Guidelines for Primary Source Literacy core ideas of the analytical, ethical, theoretical, and practical. Potential affective experiences were also examined …

Reprogramming Aerobic Metabolism Mitigates Streptococcus Pyogenes Tissue Damage In A Mouse Necrotizing Skin Infection Model, Wei Xu, Tara R Bradstreet, Zongsen Zou, Suzanne Hickerson, Yuan Zhou, Hongwu He, Brian T Edelson, Michael G Caparon

2020-Current year OA Pubs

Disease tolerance is a host response to infection that limits collateral damage to host tissues while having a neutral effect on pathogen fitness. Previously, we found that the pathogenic lactic acid bacterium Streptococcus pyogenes manipulates disease tolerance using its aerobic mixed-acid fermentation pathway via the enzyme pyruvate dehydrogenase, but the microbe-derived molecules that mediate communication with the host's disease tolerance pathways remain elusive. Here we show in a murine model that aerobic mixed-acid fermentation inhibits the accumulation of inflammatory cells including neutrophils and macrophages, reduces the immunosuppressive cytokine interleukin-10, and delays bacterial clearance and wound healing. In infected macrophages, the …

Superior Preclinical Efficacy Of Co-Treatment With Brg1/Brm And Flt3 Inhibitor Against Aml Cells With Flt3 Mutations, Warren Fiskus, Christopher P Mill, Jessica Piel, Mike Collins, Murphy Hentemann, Branko Cuglievan, Christine E Birdwell, Kaberi Das, Hanxi Hou, John A Davis, Antrix Jain, Anna Malovannaya, Tapan M Kadia, Naval Daver, Koji Sasaki, Koichi Takahashi, Danielle Hammond, Patrick K Reville, Lauren B Flores, Sanam Loghavi, Xiaoping Su, Courtney D Dinardo, Kapil N Bhalla

Faculty, Staff and Student Publications

Although treatment with standard frontline therapies, including a FLT3 inhibitor (FLT3i) reduces AML burden and achieves clinical remissions, most patients with AML with FLT3 mutation relapse due to therapy-resistant stem/progenitor cells. The core ATPases, BRG1 (SMARCA4) and BRM (SMARCA2) of the canonical (c) BAF (BRG1/BRM-associated factor) complex is a dependency in AML cells, including those harboring FLT3 mutations. We have previously reported that treatment with FHD-286, a BRG1/BRM ATPases inhibitor, induces differentiation and loss of viability of AML stem/progenitor cells. Findings of present studies demonstrate that treatment with FHD-286 induces lethality in AML cells, regardless of sensitivity or resistance to …

Fast & Fair Peer Review: A Bold Experiment In Scientific Publishing, Daniel A Gorelick, Alejandra Clark

Faculty, Staff and Students Publications

No abstract provided.

Empowering Young Innovators Through School-Based Agricultural Education: Insights From A Nigerian Secondary School Teacher, Mary O. Olumide-Oyaniyi

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Nigeria faces challenges like food insecurity and economic instability, worsened by a growing youth population. School-Based Agricultural Education (SBAE) engages youth in agricultural innovations. This study implemented SBAE principles in a Nigerian school, combining poultry farming and aquaculture. Students managed a poultry farm, using chicken droppings to breed maggots as feed for catfish in rainwater-filled tanks. The project enhanced students' skills, improved local food production, and engaged the community. Despite funding and management challenges, the initiative demonstrated SBAE's potential to empower youth and advance agricultural practices, offering a model for similar projects in other regions.

The Few-Nexus: Using Soil To Grow Meaning And Relevance In Undergraduate General Education Earth Science Courses, Katherine Mccarville

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

Soils are central to human survival, through their critical roles in regulating water supplies and providing the medium for most agricultural productivity. Even as fewer and fewer students know where their water and food come from, and where their wastes go, soils tend to be under-emphasized in Earth science general education courses. Combining a place-based focus on soils with the FEW-Nexus model provides an integrating context for concepts and information that students sometimes perceive as disconnected and irrelevant to them. This approach can transform the experiences and learning of undergraduate students in the Earth science general education curriculum.

Learning Food Supply Chains Through Generative Ai – Tips, Techniques, And Student Perceptions, Subbu Kumarappan, Urmila Pal Chaudhuri

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

The classroom pedagogies are evolving significantly with Generative Artificial Intelligence (GenAI). The students in a Food Supply Chains class completed a project for various agricultural products describing 12 factors and 7 supply chain principles. They reflected on the use of GenAI and how it impacted their knowledge and critical thinking skills. The students scored GenAI high on ‘relevancy, diverse topics, significance, and sufficiency;' the repeated use of GenAI for food supply chains enabled them recognize the importance of sustainability and ESG factors in the management of natural resources. There were differences in students use and benefits with GenAI use.

Integrating The Few-Nexus Into An Agricultural Issues Course, Christopher M. Estepp, Hannah Scherer

National Collaborative for Research on Food, Energy, and Water Education (NC-FEW)

To address the global challenges facing the agricultural industry, graduates of agricultural degree programs must learn to utilize systems thinking skills, which can help them view the interconnectedness among issues and design holistic solutions. The Food-Energy-Water (FEW)-Nexus is an interdisciplinary framework that can support undergraduate student achievement of sustainability education competencies, including systems thinking. This project utilized the FEW-Nexus framework in an agricultural issues course to help students improve their systems thinking. Students were given lectures on various agricultural issues by experts in those areas. Two assignments, agricultural issue concept maps and critical reflections over each speaker’s session were completed …

Rehydrating The Church: The Lifegiving Role Of The Holy Spirit In Christian Formation, Ministry, Leadership, And Community, Rand Burden

Doctor of Ministry

NPO Statement

Many small rural Global Methodist Church (GMC) congregations have limited access to pastors and, as such, are in critical need of alternative forms of spiritual leadership.

Key Insights

Life in the Spirit must precede spiritual leadership. The church desperately needs members and leaders living lives led by, walking after, and informed by the Spirit. It is my conviction that with an increased awareness of the Spirit, a desire for intimacy will arise, a drawing to wade into the Water of Life, to be more open to desire and experience a deeper encounter with and understanding of the Holy …

The Bison, March, 14, 2025

The Bison Newspapers

No abstract provided.

Ucc Minutes Mar 14, 2025, Undergraduate Curriculum Committee

Undergraduate Currirculum Committee Minutes

No abstract provided.

Doc 2025-02 Neuroscience Co-Major, Full Program Proposal, University Of Dayton. Department Of Biology, College Of Arts & Sciences

Senate Documents

The Department of Biology in the College of Arts & Sciences (CAS) proposes to establish an innovative Co-Major in Neuroscience program. This Co-Major will comprise a new program offering in the Department of Biology complementing the existing Minor in Neuroscience.

March 14, 2025, Csusb

Coyote Chronicle (1984-)

No abstract provided.

Physical And Biological Effects On Moths’ Navigation Performance, Yiftach Golov, Roi Gurka, Alexander Liberzon, Ally Harari

Physics and Engineering Science

In a chemosensing system, the local olfactory environment experienced by a foraging organism is defined as an odorscape. Using the nocturnal pink bollworm moth (Pectinophora gossypiella), we tested the combined effect of three biophysical aspects in its immediate odorscape to shed light on the coupling effects of biotic and abiotic factors on navigation performances of a nocturnal forager: i) the quality of the pheromone source, ii) the pheromone availability, and iii) the airflow characteristics. The navigation performance of the males was investigated using a wind tunnel assay equipped with 3D infrared high-speed cameras. The navigation performance of the males was …

Strategies To Improve Antibody-Mediated Protection Against Herpes Simplex Virus Infections, Matthew D. Slein

Dartmouth College Ph.D Dissertations

No efficacious vaccine exists for herpes simplex virus and the global burden of disease remains high. Antibodies can serve as potent therapeutics to protect high risk populations such as neonates. Although rare, neonatal HSV (nHSV) infections can result in significant mortality and lifelong neurological morbidity even with antiviral therapy. While HSV-specific maternally derived antibodies significantly reduce the risk of neonatal disease in humans, the mechanisms by which they mediate protection have yet to be described. Using a mouse model of neonatal HSV (nHSV) infections we aimed to determine the mechanisms of antibody-mediated protection using monoclonal antibodies (mAbs) targeting two of …