Digital Commons Network^™

The Ai Doppelgänger Dilemma: Cloned Voices In The Music Industry, Elizabeth Shields

Seattle University Law Review

With the rise of generative artificial intelligence (AI), there has been an influx of “voice clones”—deep-learning algorithms that create synthetic speech to realistically mimic human voices. Celebrities and, in particular, music artists, have been subjected to the proliferation of AI voice clones on social media platforms like TikTok and streaming platforms such as Spotify. Despite music utilizing AI voice clones having amassed much popularity, this technology can be harmful and highly invasive to musicians whose livelihoods often depend on their distinct voices. While legal scholars have attempted to articulate various rights that could protect a person’s voice, individuals are largely …

A Century Of Depicting Characters With Disabilities In Newbery Award And Honor Books, Merna Kay Raines

Theses and Dissertations

A Century of Depicting Characters With Disabilities in Newbery Award and Honor Books Merna Kay Raines Department of Counseling Psychology and Special Education, BYU Educational Specialist Between 1922 and 2021, 426 books received the Newbery Award, with 64 books featuring characters with disabilities. However, it was not until 1931 that the Newbery Honor Award was given to recognize the author of a book featuring a character with disabilities. Newbery Award-winning books are considered quality literature and are found in most libraries and classrooms. Understanding the portrayal of characters with disabilities is important because students easily access these books. This content …

Trpm2 Overactivation Drives Hyperlipidemia-Induced Dysfunction Of Myeloid Cells And Neurovascular Units., Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison, Yasuo Mori, Barbara Miller, Rajkumar Verma, Bruce Liang, Lixia Yue

Faculty Research 2025

Hyperlipidemia induces cellular dysfunction and is strongly linked to various diseases. The transient receptor potential channel melastatin 2 (TRPM2) plays a critical role in endothelial injury, immune cell activation, and neuronal death. We reveal that TRPM2 expression in human peripheral leukocytes strongly correlates with plasma lipid levels. In middle-aged Apoe/ mice, global, myeloid, and endothelial TRPM2 knockout or TRPM2 inhibition abolishes the hyperlipidemia-induced exacerbation of ischemic brain injury suggesting that TRPM2 overactivity caused by hyperlipidemia predisposes these cells to dysfunction during ischemia. Using a clinically relevant ischemic brain injury mouse model, we demonstrate TRPM2’s pivotal role in medi- ating hyperlipidemia’s …

Electromagnetic Therapy Potential Tool For Improving Dairy Herd Health, Nicholas Gosling

UNH Today Archive

No abstract provided.

Let The Sunshine In: Crafting Constitutional Transparency Regulations For Content Moderation, Caitlin Ring Carlson

Seattle University Law Review

In response to public concern about the impact of social media, legislators in some U.S. states have developed laws to regulate the process of content moderation. Many include mandatory transparency and disclosure requirements, some of which courts have already deemed an unconstitutional infringement on social media platforms’ right to free expression. This article explores the parameters for crafting constitutional social media transparency regulations using existing U.S. media policy and insights from recent legal challenges. The resulting analysis identifies content neutral transparency requirements that mandate the disclosure of purely factual, non-controversial information as those most likely to withstand judicial scrutiny. Specifically, …

This Is Not A Game: The Addictive Allure Of Digital Companions, Nizan Geslevich Packin, Karni Chagal-Feferkorn

Seattle University Law Review

Artificial Intelligence (AI) agents have become an inescapable part of modern childhood, reshaping education, leisure activities, entertainment, and social interaction. From AI-powered tutors that adapt to individual learning styles to emotionally responsive chatbots that simulate human companionship, these systems promise unprecedented personalization, cognitive stimulation, and social support. However, these benefits mask significant risks that remain unregulated and inadequately addressed.

Although adults are also susceptible to forming deep emotional bonds with AI companions—often trusting them as if they possessed genuine understanding and empathy—children are particularly vulnerable. Their misplaced trust can more severely distort social development, weaken critical thinking, and foster unhealthy …

Cover And Contents

Turkish Journal of Zoology

No abstract provided.

Perceptions Of Artificial Intelligence In Healthcare: A Qualitative Study Among Physicians And Nurses In Florida, Aaron Miri

MUSC Theses and Dissertations

This investigation will leverage participant focus group interviews with 32 clinicians (16 nurses / 16 physicians) to study what, if anything, is inhibiting AI adoption across the hospital. Specific physicians will be sourced across the key service lines of primary care, oncology, cardiology, behavioral health, and emergency department medicine, as these tend to be patient volume driven and thus have the maximum amount of potential for positive impact leveraging AI. Nurses in these same departments will be assessed to analyze if there is a similarity or difference between the nursing and physician AI adoption barriers.

The Autophagy Protein Atg14 Safeguards Against Unscheduled Pyroptosis Activation To Enable Embryo Transport During Early Pregnancy, Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, Ramakrishna Kommagani

2020-Current year OA Pubs

Recurrent pregnancy loss, characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition to embryo quality and endometrial function, proper oviduct function is also essential for successful pregnancy establishment. Therefore, structural abnormalities or inflammation resulting from infection in the oviduct may impede the transport of embryos to the endometrium, thereby increasing the risk of miscarriage. However, our understanding of the biological processes that preserve the oviductal cellular structure and functional integrity is limited. Here, we report that autophagy-related protein ATG14 plays a crucial role in maintaining the cellular integrity of the oviduct by …

Mistargeted Retinal Axons Induce A Synaptically Independent Subcircuit In The Visual Thalamus Of Albino Mice, Sean Mccracken, Liam Mccoy, Ziyi Hu, Julie A Hodges, Katia Valkova, Philip R Williams, Josh L Morgan

2020-Current year OA Pubs

In albino mice and EphB1 knockout mice, mistargeted retinal ganglion cell axons form dense islands of axon terminals in the dorsal lateral geniculate nuclei (dLGN). The formation of these islands of retinal input depends on developmental patterns of spontaneous retinal activity. We reconstructed the microcircuitry of the activity-dependent islands and found that the boundaries of the island represent a remarkably strong segregation within retinogeniculate connectivity. We conclude that when sets of retinal input are established in the wrong part of the dLGN, the developing circuitry responds by forming a synaptically isolated subcircuit within the otherwise fully connected network. The fact …

Dried Blood Spots To Assess Cardiovascular-Kidney-Metabolic Health, Tyler A Jacobson, Mark D Huffman, Et Al.

2020-Current year OA Pubs

Dried blood spot sampling offers a scalable strategy to close diagnostic gaps and improve global surveillance for cardiovascular-kidney-metabolic syndrome. However, assay performance and the extent of validity vary widely between biomarkers used in cardiovascular-kidney-metabolic health assessment under different settings and have not been well described. To fill this gap, we conducted a systematic search of the literature and a narrative synthesis through April 2024 and included reports with laboratory or field validation measuring biomarkers that can be used in cardiovascular-kidney-metabolic health assessment. We categorized assays into categories based on laboratory validation: excellent performance (r>0.95 with gold standard methods and …

Hatching And Caring For Chicks, Cory Farnsworth, Jacob Hadfield, Ashley Longmore

All Current Publications

There are many reasons people are interested in raising birds. Most people who desire to start are interested in saving money and becoming more self-sufficient. Many people find excitement in hatching eggs and raising chicks. This fact sheet will help you get started with hatching eggs and raising chicks.

Using Thermal Camera Drones In Beef Cattle Roundup, Justin Wyatt Clawson, Eric Galloway, Shalyn Drake, Shawn Barstow, Ross Israelsen, Michael Pate

All Current Publications

Using drones with thermal sensors can be an effective tool in finding and collecting livestock from summer mountain ranges in the West. Drones can complete searches in much less time than required on horseback in demonstrated areas. Using drones reduces the workload of the rider and horse, saving time and energy and reducing the risk of injury. With proper training and certification, livestock producers can use drones to locate cattle and perform many other cost-cutting operations.

Dietary Effects On The Retina Of Hamsters, Nicole El-Darzi, Natalia Mast, Yong Li, Irina A. Pikuleva

Faculty Scholarship

The retina is a sensory tissue in the back of the eye, which captures visual information and relays it to the brain. The retinal pigment epithelium separates the neural retina from the choroidal (systemic) circulation and is thereby exposed to circulating lipoprotein particles. Herein, we used hamsters and conducted various retinal evaluations of animals fed either a normal diet or a Western-type diet (WTD). Prior to evaluations, hamsters were injected with indocyanine green (ICG), a fluorescent dye that binds to various proteins and lipids in the systemic circulation. The WTD increased plasma levels of total and HDL cholesterol 1.8- and …

Predicting The Suitable Habitats Of Alosimus Marginicollis (Haag-Rutenberg, 1880) (Coleoptera: Meloidae) And Evaluating Its Potential Distribution In Relation To Geographical And Climatic Barriers, Muhammed Ari̇f Demi̇r, Mahmut Kabalak

Turkish Journal of Zoology

The main objective of this study was to predict the ecological requirements of Alosimus marginicollis (Haag-Rutenberg, 1880), for which limited ecological information is available, and to predict possible suitable habitats under current conditions and different future scenarios. An ensemble model-based approach, combining multiple algorithms (GAM, GLM, MARS, MaxEnt), was used to predict suitable habitats for this species using bioclimatic, topographic and land cover variables. The models indicated that the elevation variable among the topography variables, BIO15 (precipitation seasonality) and BIO4 (temperature seasonality) among the bioclimatic variables, and the cropland variable (cultivated and managed vegetation cover) among the land cover variables …

Morphological, Linear, And Geometric Morphometric Differences (Skull, Mandible, And Pelvis) Among Subspecies Of Talpa Levantis (Eulipotyphla: Talpidae) With Molecular Divergence (Mtdna And Nuclear Dna), Ahmet Yesari̇ Selçuk, Alaetti̇n Kaya, Haluk Kefeli̇oğlu

Turkish Journal of Zoology

In this study, we conducted comprehensive analysis to determine the morphological, linear morphometric, and geometric morphometric differences between three subspecies of Talpa levantis: T. levantis levantis, T. levantis dogramacii, and T. levantis transcaucasica. Molecular analyses including mitochondrial DNA (complete cyt b gene) and nuclear DNA (BRCA-2) were also used. The subspecies of T. levantis showed similarities in the parastyle of the first upper molar and the mesostyle of the second and third upper molars, as well as in the morphology of the pelvis and linear measurements of the ventral skull, mandible, and pelvis. T. levantis dogramacii and T. levantis levantis …

Sk8er Skull, David Norton

College of Computing and Digital Media Dissertations

Sk8r Skull is a single player video game where players must traverse the environment as a skull on a skateboard, in an effort to defeat the wizard who has stolen the rest of the skull’s body. Players must move, destroy, and grind their way through the level in order to reach the wizard. By traversing the area, players will learn the mechanics of the game, as well as some of the in-game world’s backstory. The production of Sk8r Skull was driven by examining game feel, and the “flow” state.

Spartan Daily, March 18, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 23

The Metaphysics Of Frank Herbert's Dune And God Emperor Of Dune: On Time And Language, Garrett J. Busshart

LSU Doctoral Dissertations

This dissertation studies the metaphysics of time and rhetoric in the science fiction novels Dune (1963) and God Emperor of Dune (1981) by Frank Herbert. The first chapter critiques the protagonist’s sense of temporality, an ideology in which the future consists of multiple possible choices while each decision of one forecloses a still larger set. Jean-Pierre Dupuy calls this a “supermarket” model of temporality, as if the future were a contingent-free menu of possibilities a subject is free to pick between. My assertion is that this sense of temporality—the Western norm—matches the protagonist’s, Paul Atreides’s, rhetoric. In disclosing Paul’s sense …

Icos-Expressing Car-T Cells Mediate Durable Eradication Of Triple-Negative Breast Cancer And Metastasis, Shelley Herbrich, Mehdi Chaib, Padmanee Sharma

Faculty, Staff and Student Publications

Triple-negative breast cancer (TNBC) remains one of the most aggressive and therapeutically challenging breast cancer subtypes. In their recent study, Cao et al introduced a B7H3-specific chimeric antigen receptor (CAR)-T cell with constitutive inducible co-stimulator (ICOS) expression (ICOS-B7H3-CAR-T), which demonstrated eradication of TNBC, including metastases, in preclinical models. These CAR-T cells exploit the expression of ICOS ligand on TNBC cells, enhancing antitumor cytotoxicity through ICOS signaling. Compared with conventional B7H3-CAR-T cells, the ICOS-B7H3-CAR-T cells exhibited superior antitumor efficacy, increased cytokine secretion, and prolonged survival in xenograft murine models. This study highlights ICOS as a promising co-stimulatory molecule for improving CAR-T …

Near-Infrared Fluorescence Imaging With An Met-Targeting Probe For Biopsy Site Selection In Patients With Oral Potentially Malignant Disorders, Jingbo Wang, Xuemin Shen, Qifan Ma, Lin Yang, Xiaoyu Zhou, Luting Wang, Junqi Cui, Chunye Zhang, Guojun Li, Neil Gross, Siyi Li, Ruimin Huang, Changyou Zhan, Zhen Cheng, Kun Wang, Jie Tian, Ying Yuan, Xiaofeng Tao

Faculty, Staff and Student Publications

Accurate detection of malignant transformation in oral potentially malignant disorders (OPMDs) is crucial for guiding effective treatment and improving patient management. This study evaluates the potential of MET-binding peptide-indocyanine green (cMBP-ICG), a mesenchymal-epithelial transition factor (MET)-targeted near-infrared fluorescence imaging (NIRFI) probe, for biopsy site selection in OPMDs. Preclinical results demonstrate the superior accuracy of NIRFI-assisted biopsy over conventional oral examination (COE)-based biopsy in detecting high-grade dysplasia (HGD) or squamous cell carcinoma (SCC) and reducing missed detection rates. In a clinical trial with 50 patients, NIRFI-assisted biopsy achieves significantly higher diagnostic accuracy compared to COE-based biopsy (91% vs. 72%, p = …

Principals’ Perceptions Of Covid-19 Learning Strategies’ Influence On Reading Achievement In Title I Urban Elementary Schools, Kadian Alicia Grant

Walden Dissertations and Doctoral Studies

The COVID-19 pandemic significantly intensified reading achievement challenges among Title I urban elementary school students. There was a need to understand the impact of district-implemented strategies to improve reading achievement during the pandemic. Guided by Fullan’s educational change theory, this qualitative case study explored principals’ perceptions of the influence of district strategies on reading achievement implemented due to the COVID-19 pandemic during the 2021–2022 school year, particularly in Title I urban elementary schools. The study specifically aimed to explore (a) principals’ perceptions of the influence of lesson acceleration, (b) principals’ perceptions of the influence of personalized learning, and (c) challenges …

Did Raja Asterias Ever Occur In The Sea Of Marmara Or Were Previous Records Just Cases Of Misidentified Raja Clavata?, Hakan Kabasakal, Uğur Uzer, Fi̇rdes Saadet Karakulak

Turkish Journal of Zoology

The current inventories of elasmobranchs in the Sea of Marmara have some taxonomic problems that need to be solved. One problematic species in the elasmobranch fauna of the region is Raja clavata Linnaeus, 1758, and atypically coloured specimens of this skate species may have been misidentified in the past as congeners or closely related species. The present results show that R. asterias may be a misidentified species of the family Rajidae due to confusion with the atypically coloured R. clavata. As taxonomy is central to the integration of data sources in the context of biodiversity research and management of any …

Integrative Taxonomy Reveals The Existence Of A New Species Of Fat-Tailed Scorpions, Androctonus (Buthidae), In Iran, Hossein Barahoei, Omid Mirshamsi, Masoumeh Amiri, Asma Moeinadini, Ehsan Rakhshani

Turkish Journal of Zoology

Two species of Androctonus have been reported to date from Iran: Androctonus crassicauda (Olivier, 1807) and A. sistanus Barahoei and Mirshamsi, 2022, which is distributed only in the southeast of Iran. Investigating and identifying the distribution range of dangerous species is critically important for scorpion management. A total of 105 specimens of Androctonus were collected from representative locations in Esfahan, Yazd, Kerman, Hormozgan, Hamadan, and Khuzestan provinces. These samples were studied morphologically, morphometrically, molecularly (COI gene sequencing), and through species distribution modeling (SDM) using the MaxEnt model. Four Androctonus species were identified through the morphological and molecular studies: A. crassicauda, …

Best Practices For Imaging Of Transcatheter Valve Failure: An Update From The Heart Valve Collaboratory, Omar K Khalique, Syed Zaid, Gilbert H L Tang, Mohamed Abdel-Wahab, Miriama Akodad, Vinayak N Bapat, Jeroen J Bax, Daniel J Blackman, Philipp Blanke, Sabine Bleiziffer, Davide Capodanno, Joao L Cavalcante, Lakshmi P Dasi, Ole De Backer, Matthiew De Beuel, Alison Duncan, Marc R Dweck, Miho Fukui, Aakriti Gupta, Kentaro Hayashida, Howard C Herrmann, Tsuyoshi Kaneko, Nicole Karam, Jaffar M Khan, Jan Kovac, Uri Landes, Jonathon A Leipsic, Martin B Leon, Michael J Mack, Mahesh V Madhavan, Moody M Makar, Raj R Makkar, Mouaz Al Mallah, David Meier, Thomas Modine, Atsushi Okada, Roosha K Parikh, Radoslaw Parma, Dhairya Patel, Philippe Pibarot, Bernard Prendergast, Nishath Quader, Michael J Reardon, Toby Rogers, Lucy M Safi, Stephanie L Sellers, Sabah Skaf, Giuseppe Tarantini, Didier Tchetche, Nicolas Van Mieghem, Dee Dee Wang, John G Webb, Stephan Windecker, Steven J Yakubov, Victoria Delgado, Rebecca T Hahn, Hasan Jilaihawi

Faculty, Staff and Students Publications

This updated Heart Valve Collaboratory framework addresses the growing concern for transcatheter valve failure (TVF) following transcatheter aortic valve replacement (TAVR). With the increasing volume of redo-TAV and surgical TAV explantation, there is a critical need for standardized pathways and protocols for evaluating TVF using echocardiography and cardiac computed tomography (CT) angiography. This document clarifies prior definitions of bioprosthetic valve deterioration and bioprosthetic valve failure in a practical, imaging directed context for TAVR. It discusses various imaging modalities for diagnosing TVF, including echocardiography, cardiac CT angiography, cardiac magnetic resonance, and positron emission tomography/CT. Recommendations are provided on the systematic imaging …

Guanine Nucleotide Biosynthesis Blockade Impairs Mll Complex Formation And Sensitizes Leukemias To Menin Inhibition, Xiangguo Shi, Minhua Li, Zian Liu, Jonathan Tiessen, Yuan Li, Jing Zhou, Yudan Zhu, Swetha Mahesula, Qing Ding, Lin Tan, Mengdie Feng, Yuki Kageyama, Yusuke Hara, Jacob J Tao, Xuan Luo, Kathryn A Patras, Philip L Lorenzi, Suming Huang, Alexandra M Stevens, Koichi Takahashi, Ghayas C Issa, Md Abul Hassan Samee, Michalis Agathocleous, Daisuke Nakada

Faculty, Staff and Student Publications

Targeting the dependency of MLL-rearranged (MLLr) leukemias on menin with small molecule inhibitors has opened new therapeutic strategies for these poor-prognosis diseases. However, the rapid development of menin inhibitor resistance calls for combinatory strategies to improve responses and prevent resistance. Here we show that leukemia stem cells (LSCs) of MLLr acute myeloid leukemia (AML) exhibit enhanced guanine nucleotide biosynthesis, the inhibition of which leads to myeloid differentiation and sensitization to menin inhibitors. Mechanistically, targeting inosine monophosphate dehydrogenase 2 (IMPDH2) reduces guanine nucleotides and rRNA transcription, leading to reduced protein expression of LEDGF and menin. Consequently, the formation and chromatin binding …

Emerging Clostridioides Difficile Ribotypes Have Divergent Metabolic Phenotypes, Firas S Midani, Heather A Danhof, Nathanael Mathew, Colleen K Ardis, Kevin W Garey, Jennifer K Spinler, Robert A Britton

Faculty, Staff and Students Publications

Clostridioides difficile is a gram-positive spore-forming pathogen that commonly causes diarrheal infections in the developed world. Although C. difficile is a genetically diverse species, certain ribotypes are overrepresented in human infections, and it is unclear if metabolic adaptations are essential for the emergence of these epidemic ribotypes. To identify ribotype-specific metabolic differences, we therefore tested carbon substrate utilization by 88 C. difficile isolates and looked for differences in growth between 22 ribotypes. As expected, C. difficile was capable of growing on a variety of carbon substrates. Further, C. difficile strains clustered by phylogenetic relationship and displayed ribotype-specific and clade-specific …

The Autophagy Protein Atg14 Safeguards Against Unscheduled Pyroptosis Activation To Enable Embryo Transport During Early Pregnancy, Pooja Popli, Arin K Oestreich, Vineet K Maurya, Marina N Rowen, Yong Zhang, Michael J Holtzman, Ramya Masand, John P Lydon, Shizuo Akira, Kelle Moley, Ramakrishna Kommagani

Faculty, Staff and Students Publications

Recurrent pregnancy loss, characterized by two or more failed clinical pregnancies, poses a significant challenge to reproductive health. In addition to embryo quality and endometrial function, proper oviduct function is also essential for successful pregnancy establishment. Therefore, structural abnormalities or inflammation resulting from infection in the oviduct may impede the transport of embryos to the endometrium, thereby increasing the risk of miscarriage. However, our understanding of the biological processes that preserve the oviductal cellular structure and functional integrity is limited. Here, we report that autophagy-related protein ATG14 plays a crucial role in maintaining the cellular integrity of the oviduct by …

Author Correction: Generation Of A Tree Shrew Breast Cancer Model Using Lentivirus Expressing Pik3ca-H1047r, Li Zeng, Hong-Yan Zhang, Chuan-Yu Yang, Zhuo Cheng, Qiu-Yun Jiang, Yao Luo, Yi Li, Fu-Bing Li, Ce-Shi Chen

Faculty, Staff and Students Publications

No abstract provided.

Extracellular Dna In The Chicken Cecal Environment, Deborah Bukola Olubanjo, Artur Zbikowski, Bishnu Adhikari, Tieshan Jiang, Pallavi Singh, Seong Kang, Young Min Kwon

Poultry Science Faculty Publications and Presentations

The presence and biological role of extracellular DNA (eDNA) have been explored in diverse microbial environments. Nonetheless, it has not been studied in the chicken gut microbiome. This study aims to investigate eDNA in the chicken cecum, analyzing cecal samples from broiler chickens using three preparation methods: Whole Cecal Suspension (WCS), Washed Cell Pellets (WCP), and Cell-Free Supernatant (CFS). The 16S rRNA gene-based microbiota analysis revealed distinct microbial communities in CFS compared to WCS and WCP (p = 0.001). Notably, specific taxa, including Anaerofilum, Anaerotruncus, Oscillospira, Syntrophomonas, and Delftia, were enriched in CFS. Confocal fluorescence microscopy, employing stains such as …