Digital Commons Network^™

Phytochemical Analysis And In Vivo Anticancer Effect Of Becium Grandiflorum: Isolation And Characterization Of A Promising Cytotoxic Diterpene, Christeen Fahim, Maha R. A. Abdollah, Rola Milad, Nehal Sabry, Noha Swilam

Pharmacy

Background:Becium grandiflorum is a fragrant perennial shrub of the Lamiaceae family. Objectives: The current study aimed to explore the cytotoxic potential of the nhexane fraction from Becium grandiflorum aerial parts and, further, isolate its major diterpene and conduct in vitro and in vivo anticancer activities along with its molecular mechanism and synergy with doxorubicin. Methods: The hydroalcoholic extract of Becium grandiflorum aerial parts was fractionated, and the n-hexane fraction was analyzed via GC-MS. The major isolated diterpene, 18-epoxy-pimara-8(14),15-diene (epoxy-pimaradiene), was quantified using UPLC-PDA. Cytotoxicity assays were conducted on HCT-116, MCF-7, MDA-MB- 231, and HepG2 cell lines. The synergistic effect with …

A Study To Identify The Causal Rare Genetic Variants In Primary Open And Closed Angle Glaucoma, Pseudoexfoliation Syndrome, And Associated Glaucoma, Suganya K

Theses and Dissertations

BACKGROUND: Glaucoma is the second most common cause of blindness globally typically diagnosed with a triad of clinical symptoms of increased intraocular pressure (IOP) with associated optic disc, optic nerve head (ONH) changes, and visual field defects. Genetic and environmental factors are some of the strong aetiology factors for glaucoma and identification of these factors has a potential implication in the management of the disease and its outcome. There is a paradigm shift towards understanding the genetics of glaucoma, wherein the variants in the nuclear, mitochondrial genome and other regulatory regions are being identified as contributing risk factors.

METHODOLOGY AND …

Soft Robotic Brittle Star Shows The Influence Of Mass Distribution On Underwater Walking, Zach J. Patterson

Faculty Scholarship

Most walking organisms tend to have relatively light limbs and heavy bodies in order to facilitate rapid limb motion. However, the limbs of brittle stars (Class Ophiuroidea) are primarily comprised of dense skeletal elements, with potentially much higher mass and density compared to the body disk. To date, little is understood about how the relatively unique distribution of mass in these animals influences their locomotion. In this work, we use a brittle star inspired soft robot and computational modeling to examine how the distribution of mass and density in brittle stars affects their movement. The soft robot is fully untethered, …

Identifying Herbicides To Manage Weeds In A Buckwheat Cover Crop And For The Control Of Volunteers, Taylor Randell-Singleton, Hannah E. Wright-Smith, Lavesta C. Hand, Jenna C. Vance, A. Stanley Culpepper

Horticulture Faculty Publications and Presentations

Buckwheat (Fagopyrum esculentum) is a fast-growing plant that quickly produces a dense groundcover. The utilization of buckwheat as a cover crop in vegetable production could be beneficial to Georgia producers, however for successful adoption, weed control in the cover crop coupled with control of buckwheat volunteers must be achievable. A preemergence (PRE) and a postemergence (POST) experiment were each conducted three times in Ty Ty, GA (2020-2021) addressing these objectives. In the PRE study, acetochlor at 0.56 lb ai acre(-1) injured buckwheat up to 16% without negatively influencing growth, suggesting potential for use in buckwheat for weed control. Flumioxazin, fomesafen, …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Invasive Species From Sea To Shining Sea: An Exploration Of Different Government Responses To Invasive Species In The United States, Caroline G. Nelson

Villanova Environmental Law Journal (1991 - )

No abstract provided.

Unveiling A Hidden Hazard: A Deep Dive Into Forever Chemicals And The Urgent Need For Solutions, Katie L. Uszakiewicz

Villanova Environmental Law Journal (1991 - )

No abstract provided.

The Cowl - V. 88 N. 17 - March 27, 2025

The Cowl

The Cowl - student newspaper of Providence College. Vol. 88 No. 17 - March 27, 2025. 16 pages.

Kenyon College - March 27, 2015

The Kenyon Collegian

No abstract provided.

Efficacy Of Baits And Lures For Weasel Detection, Scott M. Bergeson, Roland Kays, David S. Jachowski, Courtney D. Anderson, Chad R. Williamson, Ashley Burket, Joseph W. Butfiloski, Amanda E. Cheeseman, Stacy Cotey, Catherine C. Dennison, John D. Erb, Zach J. Farris, Michael L. Fies, Michael J. Joyce, Colleen Olfenbuttel, Blake Sasse, Lisa M. Smith, Joshua A. Tabora, Marketa Zimova

Michigan Tech Publications

Small mustelids are difficult to survey due to their low density and cryptic nature. Population status of North American weasels (Mustela erminea, Mustela nivalis, and Neogale frenata) are believed to be in decline, but there are no standardized monitoring protocols to evaluate their status. To support weasel monitoring, we compared the attractiveness of various combinations of baits and lures to weasels in sites located throughout the eastern and central USA. We baited a total of 122 clusters of 4 camera traps, across 14 states, with random combinations of 4 baits and 3 scent lures in the winters of 2022 and …

Modeling And Characterization Of On-Orbit Servicing Architectures For Efficient Mission Planning, Samantha Q. Vi Tang

Theses and Dissertations

As space-based systems become increasingly critical to global infrastructure, efficient satellite maintenance and resource management have become essential to ensuring operational longevity. On-orbit servicing has emerged as a key strategy for extending satellite lifespans, mitigating space debris accumulation, and enhancing the cost effectiveness of space operations. This study presents a comprehensive mixed-integer programming (MIP) model to optimize servicer task assignments and routing while minimizing propellant consumption. The model captures the operational complexities of servicing a network of satellites across multiple orbits by incorporating realistic constraints, such as fuel limitations and task completion time windows. Sensitivity analysis allows mission planners to …

Awful, Yet Awe-Full: The Sublime Dystopia Of Blade Runner 2049, Charles E. Butt

USF Tampa Graduate Theses and Dissertations

Blockbuster dystopian sci-fi features stories of environmental collapse, authoritarian governments, out of control corporations, unbounded consumerism, and other awful possibilities. Scholars of science fiction broadly agree that this genre explores collective fears, anxieties, and speculations about the present and future. At the same time, film scholars have established that dystopian sci-fi cinema is compelling, and audiences respond to their effects-driven visuals, photorealistic mise-en-scene, and dramatic narratives. This creates an apparent paradox: Blockbuster cinematic aesthetics portray undesirable worlds desirably. I resolve this paradox by arguing that the worldbuilding of spectacle-driven, dystopian sci-fi cinema is Romanticized. That is, the provocative style of …

The You Inside Of You: What Is The Nature Of The Soul?, The Philosophical Discussion Group

The Philosopher's Stone

• The The You Inside of You: What is the Nature of the Soul?

Computational Methods And Optimization For Naturalistic Functional Brain Mapping Using Diffuse Optical Tomography, Morgan Fogarty

McKelvey School of Engineering Graduate Student Theses & Dissertations

Naturalistic neuroimaging has significantly advanced our understanding of the brain in everyday situations. Stimulus designs that previously targeted individual brain regions are now being replaced by activities such as watching movies, engaging in conversations, and interacting with virtual reality environments. However, traditional functional neuroimaging techniques like functional magnetic resonance imaging (fMRI) are inherently unnaturalistic, as participants must lay down and remain still within the magnet's bore. Consequently, these naturalistic paradigms require an equally naturalistic neuroimaging modality. High-density diffuse optical tomography (HD-DOT) offers a wearable alternative to fMRI by utilizing overlapping optical measurements to densely sample cortical brain activity. HD-DOT has …

Computational Methods And Optimization For Naturalistic Functional Brain Mapping Using Diffuse Optical Tomography, Morgan Fogarty

McKelvey School of Engineering Graduate Student Theses & Dissertations

Naturalistic neuroimaging has significantly advanced our understanding of the brain in everyday situations. Stimulus designs that previously targeted individual brain regions are now being replaced by activities such as watching movies, engaging in conversations, and interacting with virtual reality environments. However, traditional functional neuroimaging techniques like functional magnetic resonance imaging (fMRI) are inherently unnaturalistic, as participants must lay down and remain still within the magnet's bore. Consequently, these naturalistic paradigms require an equally naturalistic neuroimaging modality. High-density diffuse optical tomography (HD-DOT) offers a wearable alternative to fMRI by utilizing overlapping optical measurements to densely sample cortical brain activity. HD-DOT has …

Navigating The Low Covid-19 Vaccination Rate Nexus: Biblical Interpretations & Practices Of Pentecostal Christians In Dmv, Patricia Mbah Nchamukong

Walden Dissertations and Doctoral Studies

The development and release of a vaccine during an epidemic is aimed at mitigating the adverse effects of infection, transmission, and spread of the disease. However, this does not always guarantee the acceptance of the vaccine by the entire population, as was the case with the COVID-19 vaccine. The low COVID-19 vaccine rate within the Black Pentecostal Christian community in Washington, D.C., Maryland, and Virginia (DMV) is a public health concern. Some factors that might have influenced the decision of this population to accept or reject the vaccine have been linked to politics, anti-COVID-19 vaccine sentiments, and religion. The purpose …

Barriers And Breakthroughs In The Evolution Of Aggregative Multicellularity, Israt Jahan

Arts & Sciences Graduate Student Theses and Dissertations

The evolution of multicellular organization represents a key innovation in the history of life, yet fundamental questions remain about the evolutionary mechanisms that allowed some lineages to achieve remarkable complexity, while constrained others in their elaboration. The widely accepted single-cell bottleneck model provides a compelling explanation for the success of clonal multicellularity by reducing internal conflict and facilitating developmental integration. However, this perspective does not fully account for the stability and repeated evolution of aggregative multicellularity, where cooperation emerges among previously independent cells that may not be genetic relatives. Aggregative multicellularity demonstrates that the evolution of multicellularity is not a …

Mesenchymal Stem Cells Loaded In Injectable Alginate Hydrogels Promote Liver Growth And Attenuate Liver Fibrosis In Cirrhotic Rats, Dominic Karl M Bolinas, Allan John R Barcena, Archana Mishra, Marvin R Bernardino, Vincent Lin, Francisco M Heralde, Gouthami Chintalapani, Natalie W Fowlkes, Steven Y Huang, Marites P Melancon

Faculty, Staff and Student Publications

Cirrhosis, a marker of severe liver diseases, limits future liver remnant (FLR) growth, preventing many cancer patients from undergoing surgery. While portal vein blockade (PVB) techniques are used to stimulate liver regeneration, 20-30% of patients still fail to achieve the required growth. Although mesenchymal stem cell (MSC) therapy improves PVB, its efficacy is limited by poor cell retention. To address this, we utilized alginate hydrogels to deliver MSCs and improve their retention. MSCs were loaded in the hydrogel and injected intraportally in cirrhotic rats. Liver volume, weights, enzyme levels, and histology were monitored. Results showed that the hydrogel maintained 89.0 …

Independent Origins And Non-Parallel Selection Signatures Of Triclabendazole Resistance In Fasciola Hepatica, Young-Jun Choi, Bruce A Rosa, Martha V Fernandez-Baca, Rodrigo A Ore, John Martin, Pedro Ortiz, Cristian Hoban, Miguel M Cabada, Makedonka Mitreva

2020-Current year OA Pubs

Triclabendazole (TCBZ) is the primary treatment for fascioliasis, a global foodborne zoonosis caused by Fasciola hepatica. Widespread resistance to TCBZ (TCBZ-R) in livestock and a rapid rise in resistant human infections are significant concerns. To understand the genetic basis of TCBZ-R, we sequenced the genomes of 99 TCBZ-sensitive (TCBZ-S) and 210 TCBZ-R adult flukes from 146 bovine livers in Cusco, Peru. We identify genomic regions of high differentiation (F

The Mechanistic Target Of Rapamycin Mediates Clostridium Perfringens-Induced Chicken Necrotic Enteritis Attenuated By Secondary Bile Acid Deoxycholic Acid, Mohit Bansal, Tahrir Alenezi, Ying Fu, Janashrit Shrestha, Ayidh Almansour, Hong Wang, Anamika Gupta, Rohana Liyanage, Xiaolun Sun

Poultry Science Faculty Publications and Presentations

Clostridium perfringens is a prevalent gut bacterial pathogen in humans and animals. This study investigated the role of the mechanistic targets of rapamycin (mTOR) and deoxycholic acid (DCA) on C. perfringens intestinal infection. Chickens were sequentially infected with Eimeria maxima and received the mTOR inhibitor rapamycin and DCA. C. perfringens-induced necrotic enteritis (NE) was evaluated using body weight gain (BWG), histopathology, bile acids, pathogen colonization, cell infiltration and death, and gene expression. The significant difference of p < 0.05 was analyzed by one-way ANOVA and multiple comparisons. Notably, rapamycin strongly reduced the subclinical and clinical NE histopathologies. DCA and DCA combined with rapamycin alleviated clinical NE and BWG loss. Rapamycin, DCA, and DCA + rapamycin attenuated bile acid reduction in NE birds, and they also reduced immune cell infiltration into the intestinal lamina propria as well as immune cell migration in vitro. At molecular levels, DCA and DCA + rapamycin reduced proinflammatory IFN gamma, MMP9, IL23, and IL17 gene expression. Rapamycin, DCA, and DCA + rapamycin reduced NE-induced intestinal cell apoptosis. Together, these results suggest that mTOR signaling mediates C. perfringens-induced ileitis, and combining mTOR inhibition and DCA improves the intervention efficacy against NE ileitis and BWG loss.

Rheological, Interfacial, And Filtration Behavior Of Lignocellulosic Nanomaterials In Suspension And Emulsion Drilling Fluids, Meen Sung Koo

LSU Doctoral Dissertations

In recent years, the rheological aspects of suspensions/emulsions applied by cellulose nanomaterials (CNMs) have been gained considerable interests due to high gel-forming properties ascribed by hydrophilicity, crystallinity, ease functionalization, and high aspect ratio. Introducing residual lignin in CNMs (LCNMs) seemed to be capable of achieving various advantages in the application of CNMs ascribed by hydrophobicity, binding effects, and abundant aromatic groups derived from complexity of lignin. This dissertation dedicates to the characterizations of (L)CNMs, and rheological properties of (L)CNMs applied fluids (i.e., suspension and emulsion). In the suspension system, the presence of lignin in LCNMs decreased gel strength, viscosity, and …

The True Beauty Of Being Bitten By A Tick, Dereck Daschke

Journal of Religion & Film

This is a film review of The True Beauty of Being Bitten by a Tick (2025), directed by Pete Ohs.

Deepfakes And Shallow Laws: Regulating Distorted Narratives In The Political Cyberspace, Shimona Mohan, Sarthak Wadhwa

Indian Journal of Law and Technology

With a sizable section of the global population witnessing electoral churn, protests, and resistance movements in the past couple of years, this is clearly a watershed moment for modern democracies vis-à-vis technological advancements. Electoral canvassing in these democracies has expanded its footprint in the digital space, be it through social media or navigating the general contours of anonymity, engagement, and misinformation that govern our online worlds. In this context, the advent of deepfakes in the recent past, and the exponential evolution of the technology both for outreach and disruption, has invited acute regulatory attention and intervention. However, traditional policy design …

The Shorthorn: November 19, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 29, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: October 15, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: September 24, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: May 14, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 30, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.

The Shorthorn: April 23, 1929

The Shorthorn Newspaper Collection: 1920s

No abstract provided.