Digital Commons Network^™

Systemic Aging Fuels Heart Failure: Molecular Mechanisms And Therapeutic Avenues, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li

Faculty, Staff and Students Publications

Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac amyloidosis, elevating susceptibility to chronic heart failure (HF) in the elderly. Age-related cardiac dysfunction stems from prolonged exposure to genomic, epigenetic, oxidative, autophagic, inflammatory and regenerative stresses, along with the accumulation of senescent cells. Concurrently, age-related structural and functional changes in the vascular system, attributed to endothelial dysfunction, arterial stiffness, impaired angiogenesis, oxidative stress and inflammation, impose additional …

Familial Chylomicronemia Syndrome And Treatments To Target Hepatic Apoc3 Mrna, Christie M Ballantyne, Brenda F Baker, Henry N Ginsberg, Joseph L Witztum

Faculty, Staff and Students Publications

Familial chylomicronemia syndrome (FCS) is a rare, recessive monogenic disorder characterized by severely elevated plasma triglyceride (TG) levels due to absent or markedly impaired lipoprotein lipase activity, leading to a greatly increased risk of acute pancreatitis. Naturally occurring very low levels of apoC-III are associated with low TG levels; thus, apoC-III is a target for TG lowering, and therapies have been developed to reduce apoC-III. Strategies to inhibit hepatic apoC-III synthesis include antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs). In the last decade, technologies have been developed to enhance hepatic delivery of these potential therapeutic agents by conjugation of …

De Novo Variants In Rybp Are Associated With A Severe Neurodevelopmental Disorder And Congenital Anomalies, Monika Weisz-Hubshman, Lindsay C Burrage, Sharayu V Jangam, Jill A Rosenfeld, Sandra Von Hardenberg, Anke Bergmann, Manuela Friederike Richter, Malgorzata Rydzanicz, Rafal Ploski, Agnieszka Stembalska, Wendy K Chung, Rebecca R Hernan, Foong Y Lim, Theresa Brunet, Steffen Syrbe, Boris Keren, Solveig Heide, David R Murdock, Hongzheng Dai, Fan Xia, Shamika Ketkar, Brian Dawson, Vinodh Narayanan, Hillary K Graves, Undiagnosed Diseases Network, Michael F Wangler, Carlos Bacino, Brendan Lee

Duncan NRI Faculty and Staff Publications

Purpose: Polycomb group proteins are key epigenetic transcriptional regulators. Multiple neurodevelopmental disorders are associated with pathogenic variants of the genes encoding Polycomb group proteins. RYBP is a core component of the noncanonical Polycomb Repressor Complex 1; however, its role in disease is unclear.

Methods: Functional consequences of RYBP variants were assessed using in vitro cellular and in vivo Drosophila melanogaster studies.

Results: We described 7 individuals with heterozygous de novo variants of RYBP and their clinical findings, including severe developmental delay, dysmorphisms, and multiple congenital anomalies. We showed that all single-nucleotide variants in RYBP localize to the N-terminal domain of …

Foamy Monocytes And Atherogenesis In Mice With Combined Hyperlipidemia And Effects Of Antisense Knockdown Of Apociii, Jing Xiao, Benjamin A Litchfield, Xiao-Yuan Dai Perrard, Lu Xu, Jing Ni, Aparna Mukherjee, Timothy Simmons, Henry Dong, Adam E Mullick, Rosanne Crooke, Henry J Pownall, Scott I Simon, Christie M Ballantyne, Huaizhu Wu

Faculty, Staff and Students Publications

Hypertriglyceridemia (HTG), particularly in combined hyperlipidemia, increases risk for atherosclerotic cardiovascular disease, but the underlying mechanisms remain incompletely understood. We sought to determine contributions of circulating monocytes to atherosclerosis associated with HTG in combined hyperlipidemia, created by transgenic expression of human apoCIII in Ldlr−/− mice (Ldlr−/−ApoCIIItg) fed Western high-fat diet (WD). Tissue culture with THP-1 and primary human monocytes was used to examine effects of triglyceride (TG)-rich lipoproteins on monocytes. Ldlr−/−ApoCIIItg mice were also treated with apoCIII antisense oligonucleotide (ASO) and examined for foamy monocytes and atherosclerosis. Compared to Ldlr−/− mice, Ldlr−/−ApoCIIItg mice fed …

Time Tracking And Comparison Of Genetic Counseling Tasks In Inpatient And Outpatient Settings, Kristen Fishler

Faculty, Staff and Students Publications

Genetic counselors (GCs) practice in critical care settings. Some GCs have full-time inpatient roles, while most GCs who see inpatients do so as needed or on a rotating schedule in addition to seeing patients in an outpatient setting. Few studies have tracked and compared the amount of time it takes GCs to perform tasks in the inpatient and outpatient settings. Genetic counselors were invited to participate in this study via the National Society of Genetic Counselors research listserv. Participants completed an online survey asking how their role is structured and what types of support are available to them while seeing …

Clinical And Genetic Delineation Of Autosomal Recessive And Dominant Actl6b-Related Developmental Brain Disorders, Stephanie Efthymiou, Antonella Riva, Dana Marafi, Maha S Zaki, Mohnish Suri, Roberto Dominguez, Hasnaa M Elbendary, Shahryar Alavi, Mohamed S Abdel-Hamid, Heba Morsy, Frederic Tran Mau-Them, Mathilde Nizon, Pavel Tesner, Lukáš Ryba, Faisal Zafar, Nuzhat Rana, Nebal W Saadi, Zahra Firoozfar, Pinar Gencpinar, Bulent Unay, Canan Ustun, Ange-Line Bruel, Christine Coubes, Jennifer Stefanich, Ozlem Sezer, Emanuele Agolini, Antonio Novelli, Gessica Vasco, Donatella Lettori, Mathieu Milh, Laurent Villard, Shimriet Zeidler, Henry Opperman, Vincent Strehlow, Mahmoud Y Issa, Hebatallah El Khassab, Prem Chand, Shahnaz Ibrahim, Ali Rashidi-Nezhad, Mohammad Miryounesi, Pegah Larki, Jennifer Morrison, Ingrid Cristian, Isabelle Thiffault, Nicole L Bertsch, Grace J Noh, John Pappas, Ellen Moran, Nikolaos M Marinakis, Joanne Traeger-Synodinos, Susan Hosseini, Mohammad Reza Abbaszadegan, Roseline Caumes, Lisenka E L M Vissers, Maedeh Neshatdoust, Mostafa Montazer Zohour, Elmostafa El Fahime, Christina Canavati, Lara Kamal, Moien Kanaan, Omar Askander, Victoria Voinova, Olga Levchenko, Shahzhad Haider, Sara S Halbach, Rayana Elias Maia, Salehi Mansoor, Vivek Jain, Sanjukta Tawde, Viveka Santhosh R Challa, Vykuntaraju K Gowda, Varunvenkat M Srinivasan, Lucas Alves Victor, Benito Pinero-Banos, Jennifer Hague, Heba Ahmed Elawady, Adelia Maria De Miranda Henriques-Souza, Huma Arshad Cheema, Muhammad Nadeem Anjum, Sara Idkaidak, Firas Alqarajeh, Osama Atawneh, Hagar Mor-Shaked, Tamar Harel, Giovanni Zifarelli, Peter Bauer, Fernando Kok, Joao Paulo Kitajima, Fabiola Monteiro, Juliana Josahkian, Gaetan Lesca, Nicolas Chatron, Dorothe Ville, David Murphy, Jeffrey L Neul, Sureni V Mullegama, Amber Begtrup, Isabella Herman, Tadahiro Mitani, Jennifer E Posey, Chee Geap Tay, Iram Javed, Lucinda Carr, Farah Kanani, Fiona Beecroft, Lee Hane, Elsayed Abdelkreem, Milan Macek, Luciana Bispo, Marwa Abd Elmaksoud, Farzad Hashemi-Gorji, Davut Pehlivan, David J Amor, Rami Abou Jamra, Wendy K Chung, Eshan Ghayoor Karimiani, Philippe M Campeau, Fowzan S Alkuraya, Alistair T Pagnamenta, Joseph G Gleeson, James R Lupski, Pasquale Striano, Andres Moreno-De-Luca, Denis L J Lafontaine, Henry Houlden, Reza Maroofian

Faculty, Staff and Students Publications

Purpose: This study aims to comprehensively delineate the phenotypic spectrum of ACTL6B-related disorders, previously associated with both autosomal recessive and autosomal dominant neurodevelopmental disorders. Molecularly, the role of the nucleolar protein ACTL6B in contributing to the disease has remained unclear.

Methods: We identified 105 affected individuals, including 39 previously reported cases, and systematically analyzed detailed clinical and genetic data for all individuals. Additionally, we conducted knockdown experiments in neuronal cells to investigate the role of ACTL6B in ribosome biogenesis.

Results: Biallelic variants in ACTL6B are associated with severe-to-profound global developmental delay/intellectual disability, infantile intractable seizures, absent speech, autistic features, dystonia, …

The Effects Of Internalizing Symptoms And Attentional Difficulties On Adolescent Outcomes Of The Peers Intervention, Madeleine Kathleen Guell

Master's Theses (2009 -)

The Program for the Education and Enrichment of Relational Skills (PEERS) is effective at improving the social skills of autistic youth. However, few studies have examined the suitability of PEERS for youth with comorbid mental health concerns. Research suggests that autistic youth are highly likely to have co-occurring disorders such as internalizing and attentional disorders, which are linked with poorer social skills in autistic youth. The current study explores the effects of internalizing symptoms and attentional difficulties on outcomes of the PEERS intervention by examining the relationship between these symptoms and 3 composite outcome variables (i.e., social awareness, social interaction, …

Long-Term Bone Changes At Edentulous Sites, Teerarat Neal Phuatrakoon

Master's Theses (2009 -)

BACKGROUND: Tooth loss is a debilitating occurrence that may affect the patient’s emotional and mental well-being. Delays in necessary restorative treatment may occur dependent on the patient’s finances or other elaborate dental treatment plans. Prosthetically guided implants have become the standard of care regarding definitive treatment, however there is a lack of evidence discussing the stability of edentulous sites if deferment of treatment is required. OBJECTIVE: The aim of this study is to measure long-term changes of the edentulous alveolar ridge (height and width) and anatomical structures (e.g. sinus floor, inferior alveolar canal). METHODS: Charts of patients with at least …

Belial: Sexual Violence And Its Legal Remediation In The Deuteronomistic History, Samantha Jo Scott

Dissertations (1934 -)

At first glance, the pericopes of Judges 19–20, 1 Samuel 2:12–36, and 1 Samuel 30 have little in common with one another. Yet, several peculiar threads are interwoven in each pericope that signal a common bond between these narratives. In each account, the characterization of the antagonists and their deeds are the same. In Judg 19–20, בני־בליעל, lit. “sons of belial,” are responsible for the rape of the Levite’s concubine. In 1 Sam 2:12–36, Eli’s sons are called בני־בליעל, lit. “sons of belial,” and accused of exploiting the so-called gathering women. In 1 Sam 30, a portion of David’s men …

Role For Astrocytes In Complex Cognition: An Evolutionary, Behavioral And Computational Perspective, Gregory Simandl

Dissertations (1934 -)

The human brain has more computational power than modern supercomputers by utilizing only a few signaling systems, rendering it the most efficient computational device ever created. Evolution, though not prospective, has iteratively constructed neural networks of increasing complexity that have ultimately endowed humans with extraordinary cognitive abilities. Through an evolutionary lens, there is a clear correlation between organismal sophistication and network signaling complexity Astrocytes, a non-neuronal cell that makes up approximately half the cells in the human brain, show dramatic increases in morphological and signaling complexity in higher-order species. This co-evolution is likely not coincidental but rather represents the development …

Flex-Fuel Mixing-Controlled Combustion Enabled By Prechamber Ignition (Pc-Mcc), Jared J. Zeman

Dissertations (1934 -)

There is an imminent need to displace fossil diesel fuel with cleaner burning, domestically produced, renewable fuels for use in heavy-duty engines. Bioethanol is a prime candidate as it widely adopted in the U.S. as a gasoline additive ranging in volume percentage from 10% (E10) up to 85% (E85). Direct substitution of market available ethanol-gasoline blends for diesel fuel is not plausible as the stark reactivity differences would not constitute the same ignition quality nor achieve auto-ignition at all. This work focuses on the development of prechamber enabled mixing-controlled combustion (PC-MCC) as an advanced ignition strategy to facilitate reliable ignition …

Interactions Between Explicit And Implicit Memories During Sensorimotor Adaptation And After Concussion, Devon Lantagne

Dissertations (1934 -)

Sensorimotor adaptation is a form of motor learning whereby a motor skill is adjusted in the face of a disturbance to return performance to desired performance. This process uses memories of previous experiences to guide future movements. While the temporal characteristics of adaptation have been well studied, the extent to which these memories are explicit, implicit, or a mixture of both is unclear. In this Dissertation, I conduct three studies to investigate the relative contributions of sensorimotor memories when adapting to stochastic spring-like loads applied to the hand. By implementing computational modeling and system identification techniques, I fit memory models …

Region-Specific Hematological And Biochemical Reference Intervals For Southern Thai Fighting Bulls, Dhiravit Chantip, Nantaporn Chooruang, Kitikarn Sakuna, Niramol Thongtem, Wiruntita Bohman

The Thai Journal of Veterinary Medicine

Accurate health assessments are vital for the performance and welfare of fighting bulls. Existing hematological and biochemical reference intervals (RIs) for cattle may not adequately reflect the unique characteristics of fighting bulls due to breed, age, and geographical differences. This study aimed to develop and apply region-specific RIs for hematological and biochemical parameters in fighting bulls from southern Thailand. A retrospective analysis of laboratory records was conducted on 1,460 healthy fighting bulls enrolled in an annual health check program at the Livestock Animal Hospital, Faculty of Veterinary Sciences, Rajamangala University of Technology Srivijaya, from January 2016 to December 2023. Blood …

Preparation And Evaluation Of Mesoporous Celecoxib For Improved Antiarthritic Activity In Rodents, Reena I. Fernandaes, Sayani Bhattacharyya

The Thai Journal of Pharmaceutical Sciences

Background: Celecoxib, a model anti-inflammatory drug, used in the management of arthritis exhibits limited oral bioavailability and slow onset of action due to its poor solubility. Objective: The present study explores a mesoporous drug delivery of celecoxib to investigate the efficacy of its antiarthritic activity in animal models, and develops a low-oral dose therapy. Materials and Methods: The solvent evaporation method was employed for the preparation of mesoporous delivery of celecoxib, using Syloid^®, and Neusilin^®, at a molar ratio of silica/ drug 1:2.5. The formulations were characterized for drug loading, in vitro drug release, and material …

Enhancing Topical Drug Delivery Of Apremilast Through Niosomal Gel Formulation: Ex Vivo Skin Permeation And In Vivo Evaluation For Psoriasis, Megha Shyam Matlapudi, Anka Rao Areti, Yukti Jaiswal, Veeresh Bantal, Raghavender Medishetti

The Thai Journal of Pharmaceutical Sciences

Background: Psoriasis is a dynamic and chronic disease characterized by inflammatory changes and an increased rate of keratinocyte proliferation leading to the formation of erythematous scleroderma plaques with a silvery sheen. The existing therapies come with shortcomings in terms of effectiveness and leave behind a trail of side effects. Hence, there is a need of alternative therapeutic measures. Objectives: This study aimed to assess the therapeutic potential of Apremilast Niosomal Gel (APR Nio Gel) in treating psoriasis, comparing its effectiveness with conventional gel (APR Gel) and oral suspension (APR Oral) formulations. Materials and Methods: Apremilast niosomes were prepared by thin …

Study Of Laws And Regulations Related To The Management Of Florfenicol Detection Cases In Swine, Shinnawat Saengungsumalee

The Thai Journal of Pharmaceutical Sciences

Background: Florfenicol, an antibiotic permitted in veterinary medicine, currently lacks an established maximum residue limit (MRL) in meat products in Thailand, effectively mandating undetectable residue levels. In May 2024, Thailand Pesticide Alert Network reported florfenicol residues in swine, raising concerns about consumer safety, rational veterinary drug use, and the potential for antimicrobial resistance (AMR). Addressing these issues involves multiple laws, decrees, and regulations across various agencies. Objectives: To analyze laws and regulations managing florfenicol residue detection in swine. Materials and Methods: This documentary research examines relevant laws, regulations, and measures for florfenicol in livestock and compares Thailand’s regulations with those …

Justification Of Permissible Discharges Of Water Users Into Water Bodies, Mariia S. Stroganova, Ivan V. Antonov, Andrey V. Epifanov

CHEMISTRY AND CHEMICAL ENGINEERING

The purpose of this work is developing an algorithm for ecological and technological rationing of the permissible load on water bodies using geoinformation systems. The algorithm takes into account the self-purification of aquatic ecosystems using a three-component model. Initially, the article provides an overview of methods for determining the permissible discharge masses of pollutants for developing new approaches to rationing. The algorithm of ecological and technological rationing of the load on water bodies and geoinformation systems for its implementation is proposed. The main models used to assess the ecological state of an aquatic ecosystem are considered. A three-component model of …

Separation Of Fatty Acids From Horse Fat And Their Analysis, Sherzod Y. Rakhmanov, Madina O. Khamidovа, Dilshod P. Rakhimov, Rashidah Sokur, Nuriddin T. Kenjaev

CHEMISTRY AND CHEMICAL ENGINEERING

A distinctive feature of horse fat from other animal fats is the presence of amino acids and keratin in its composition, which are not found in other oils, including polyunsaturated fatty acids, proteins, microelements, vitamins A, E, PP, B. The aim of this work is to separate fatty acids from horse fat and analyze them. The process of separating fatty acids included the stages of saponification with sodium hydroxide, decomposition of the resulting soaps in the presence of concentrated sulfuric acid. The study of the composition of the separated fatty acids by the chromatograph mass spectrometric method of analysis established …

Guaranteeing The Press, Jacob M. Schriner-Briggs

St. John's Law Review

A vibrant press is vital to meaningful self-government. Indeed, the indispensability of investigative journalism to democracy raises the stakes of the news industry’s ongoing collapse. Many of the country’s most prominent outlets are shedding jobs as local operations shutter entirely. The downstream effects of this market contraction frustrate the informed exercise of popular sovereignty.

Because journalism is a public good in the economic sense, the state must intervene to provision it. To this end, scholars have generally endorsed one of two legal bases for government action. The first argues that the First Amendment can constitutionalize press-favoring market interventions. The second …

19th Annual Research In The Capitol [Program], March 31, 2025, University Of Northern Iowa. University Honors Program. Iowa State University. Honors Program. University Of Iowa. Honors Program.

Research in the Capitol Programs

Program of research presentations given at the Capitol by students from the University of Northern Iowa, Iowa State University, and the University of Iowa.

Faculty Senate Agenda March 31, 2025, Utah State University

Faculty Senate & Faculty Senate Executive Committee

• 3:00 Call to Order
• Approval of Minutes March 3, 2025
• 3:05 University Business
• 3:20 Faculty Senate Business
• 3:35 Information
• EPC Report - March 6, 2025
• 3:40 Report
• Budget and Faculty Welfare Committee
• Sustainability Council
• Policy 323, 378, 389
• 4:00 Old Business
• 4:05 New Business
• 2025-2026 Calendar and Committee Reports
• President-Elect Nominations
• Adjourn: 4:30 pm

Bird Richness As A Mediator Between Greenspace And Mental Health Relationships, Sihao Chena, Huaqing Wang, Wenyan Xu

Landscape Architecture and Environmental Planning Faculty Publications

Neighborhood greenspaces are widely known to benefit bird diversity and human mental health. However, whether bird richness mediates the relationship between greenspace and mental health is unknown. We ascertain such mediation effects in 294 census tracts in Los Angeles City. We obtained greenspace data from one-meter resolution satellite imagery, bird species data from eBird citizen science datasets, and prevalence of poor mental health from the US Centers for Disease Control and Prevention. Mediation analysis combined with spatial error models was used to assess the mediating effects while controlling for geographic, demographic, and socio-economic factors. We found that the higher greenspace …

The Utah Statesman, March 31, 2025, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Women’S Health Considerations In Traumatic Brain Injury, Sindhoori Nalla

Department of Rehabilitation Medicine Faculty Papers

Purpose of Review: Biological sex differences are an important factor to consider when treating TBI, as there can be a disproportionate manifestation of symptoms and recovery process when comparing females to males. Historically, these differences have not been well studied, and there is still much to be understood as to why these differences exist. Recent Findings: A number of factors are thought to contribute to disparities with women who have a TBI, including lack of well-designed research studies focused on women, hormonal fluctuations at the time of and as a result of a TBI, psychosocial comorbidities, and societal norms/expectations. While …

Numaswitch, A Novel Biochemical Platform For Efficient Peptide And Protein Production, Christian Schwarz, Roxann Guerrette, Bach-Ngan Wetzel

Microbial Engineering III (MEIII)

Please click Additional Files below to see the full abstract

An Aulete Takes Flight: The Iconography Of Music And Myth In A Myrina-Type Terracotta In The Mead Art Museum, Loren Isotalo

New England Classical Journal

A Myrina-type terracotta figurine of a flying aulete held in Amherst College’s Mead Art Museum exemplifies a new body of evidence relevant to the study of ancient Greek music. I propose that this coarse figurine indicates possible musical funerary practices of Myrina and that the aulete may be a depiction of the god Eros. As the aulos inhabits a complex space in Greek social thought, a connection between Eros and the aulos would open up new ways of understanding how the ancient Greeks received and understood Eros as a god through music and sound.

Review Of Jared Hudson. 2021. The Rhetoric Of Roman Transportation. Vehicles In Latin Literature. Cambridge: Cambridge University Press. Pp Xvi, 353. Paperback. (Isbn 978-1-108-72323-7) $46.59., Ray Laurence

New England Classical Journal

No abstract provided.

Operating Fund Budget/ Expenditure Summary Report 2024-25, Csusb Budget Office

University Budget Office records

No abstract provided.

Out With The Old, In With The Young? Youth And Old Age In Vergil’S Eclogues And Georgics, Charissa Skoutelas, Anthony Smith

New England Classical Journal

Scholars have noted that Silenus’ entrapment by Chromis and Mnasyllos (Eclogues 6) and Aristaeus’ ambush of Proteus (Georgics 4) share distinct elements. Both passages portray youths forcefully binding an old figure with chains to compel a song. In comparing old Silenus and Proteus with the “boys” Chromis and Mnasyllos and “most daring of the youth” Aristaeus respectively, this paper traces such physical compulsion alongside the metaphorical confinement of Tityrus (Eclogues 1) and the Corycian senex (Georgics 4) to argue that Vergil mobilizes the clash of youth and senectitude to comment on the effects of literary tradition …

Basilissa: Exploring Cleopatra Selene’S Complex Identity Through Her Coinage, Btari Laksono

New England Classical Journal

No abstract provided.