Digital Commons Network^™

Integrated Phenotypic And Proteomic Screening Identifies Top-Tier Alzheimer's Disease Therapeutic Targets., Gregory Cary, Qianjin Li, Jesse C Wiley, Carolyn Paisie, Yuhong Du, Elizabeth L Zoeller, Duc Duong, Haian Fu, Nicholas T Seyfried, Allan I Levey, Ranjita Betarbet, Gregory W. Carter, The Emory-Sage-Sgc-Jax Treat-Ad Center

Faculty Research 2025

INTRODUCTION: Alzheimer's disease (AD) is a complex neurodegenerative disorder. Hundreds of therapeutic targets have been nominated through genetic and multi-omic studies, but effective prioritization remains a major bottleneck.

METHODS: We applied an integrative screening framework to assess 29 candidate targets from risk-enriched biological domains. Using disease-relevant murine BV2 microglial cell lines with stable Psen2 knockdown, we performed small interfering RNA-mediated perturbations followed by cellular phenotypic assays and quantitative proteomics.

RESULTS: Twenty-five candidate targets significantly altered at least one phenotype, with stronger effects in Psen2 knockdown cells. Integrated proteomic analyses identified several perturbations that reversed AD-associated molecular patterns. Five targets-Ap2a2, Pdhb, …

Issue 16: Pulmonary & Critical Care Insider, Bharat Bajantri Md, Sarah Ellsworth Mls

Critical Care & Pulmonary

Pulmonary & Critical Care Insider Issue 16

Compiled by Bharat Bajantri, MD, and librarian Sarah Ellsworth, MLS for the clinicians of the Pulmonary and Critical Care team of Parkview.

The Pulmonary & Critical Care Insider newsletter was created by Dr. Bharat Bajantri, MD and Sarah Ellsworth, MLS in 2023 as a form of current awareness for current practice at our hospital, Parkview Health.

Topics:

EVERDAC Trial: Do All Shock Patients Need Arterial Lines?

Beyond MAP: Redefining Perfusion Pressure in Septic Shock

ECG Findings You Cannot Miss in Acute Pulmonary Embolism

Food for Thought: When Private Equity Buys Hospitals, Who Pays …

Interconexiones Del Diseño, María Del Mar Martínez-Oña

Libros

El presente libro es un trabajo colectivo de diferentes investigadores e investigadoras donde se confirma la relación, unión o conexión entre dos o más disciplinas académicas, estableciéndose entre todas ellas, un indiscutible nexo, EL DISEÑO. Diseño, que se manifiesta a través de diversos capítulos que indagan como el pasado, presente y futuro del diseño, de forma silenciosa se encuentra arraigado no solo en todas las disciplinas académicas, sino también en todos los ámbitos de la sociedad.

El diseño, como campo multidisciplinario, mantiene conexiones profundas con numerosas áreas del conocimiento. Estas relaciones enriquecen tanto al diseño como a las disciplinas con …

The Mayfly Newsletter, Donna Giberson

The Mayfly Newsletter

The Mayfly Newsletter is the official newsletter of the Permanent Committee of the International Conferences on Ephemeroptera.

Neurogenesis And Functional Recovery Of Murine Retinal Ganglion Cells After Glaucoma Induction Following Treatment With Pnu-282987, Samantha Luzadre

Masters Theses

Experiments were performed to demonstrate electrical recovery in glaucoma-induced adult mice after neurogenesis of retinal ganglion cells (RGCs). Newly derived RGCs were induced following eye drop treatment with a selective alpha7 nicotinic acetylcholine receptor agonist, PNU-282987. Both sexes of transgenic (RlbpCre-ER (CRE⁺) and Rosa-tdTomato (tdTomato⁺)) adult mice were utilized to trace newly generated RGCs originating from Müller glia (MG). Experimental mice were injected with hypertonic saline into the episcleral vein of anesthetized mice to significantly increase intraocular pressure (IOP) and induce glaucoma-like conditions. One month after the injection and after significant death of RGCs occurred, mice …

What Is The Standard Of Review For (Mixed) Constitutional Questions?, Anthony Sangiuliano, Mark Friedman

UBC Law Review

No abstract provided.

Analyzing Santa Clara University’S Food Procurement, Grace Falci, Isabelle Pink

Sustainable Food Systems Fellowship

As Food Systems Fellows (January - December 2025), we evaluated the environmental and social impacts of Santa Clara University’s food procurement system in partnership with the Center for Sustainability and SCU Auxiliary Services. Using the Real Food Challenge framework, we assessed SCU Dining Services’ progress toward sustainability commitments outlined in Leading Through Laudato Si’, including expanding sustainable purchasing, increasing plant-based spending, and sourcing ethically produced food. Analysis showed that 19.27% of food purchases in February and October 2024 met Real Food criteria. This is below prior-year Real Food percentages and the university’s 25% by 2025 goal. To accelerate progress, we …

Computational Fluid Dynamics Based Optimization Method Applied To Hydrokinetic Turbine Devices, Stuart Glenn Fletcher

Graduate Theses and Dissertations

This thesis presents a computational investigation of optimal kinematic operating parameters governing various hydrokinetic turbines (HKT) systems for the use of power generation within river and tidal environments. Two separate studies are performed. The first study investigates optimal cycle parameters for simple and complex kinematic modes governing the motion of oscillating foil energy harvesters (OFEH). An iterative gradient-ascent optimization method is used to search for local efficiency optima based on an initial set of kinematic parameters. To search the operational space for up to eight degrees of freedom (DOF), a maximin space filling condition was implemented to efficiently compute initial …

Diagnostic Accuracy Of Nanopore Sequencing For Detecting Mycobacterium Tuberculosis And Drug-Resistant Strains: A Systematic Review And Meta-Analysis, Timothy Hudson David Culasino Carandang, Dianne Jaula Cunanan, Gail S. Co, John David Pilapil, Juan Ignacio Garcia, Blanca I. Restrepo, Marcel Yotebieng, Jordi B. Torrelles, Kin Israel Notarte

Ateneo School of Medicine and Public Health Publications

Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB) infection, remains a significant public health threat. The timeliness, portability, and capacity of nanopore sequencing for diagnostics can aid in early detection and drug susceptibility testing (DST), which is crucial for effective TB control. This study synthesized current evidence on the diagnostic accuracy of the nanopore sequencing technology in detecting MTB and its DST profile. A comprehensive literature search in PubMed, Scopus, MEDLINE, Cochrane, EMBASE, Web of Science, AIM, IMEMR, IMSEAR, LILACS, WPRO, HERDIN Plus, MedRxiv, and BioRxiv was performed. Quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. Pooled …

Impacts Of Nutrient Addition And Disturbance On Coastal Dune Arthropod Communities And Trophic Interactions, Kayla Beitzel

Graduate Theses and Dissertations (2019 - present)

Coastal dune ecosystems face ongoing threats from human-mediated disturbance and altered resource availability. Because these dunes provide critical habitat for many organisms, including shorebirds, beach mice, and arthropods, changes in disturbance regimes or resource availability can impact plant communities and higher trophic levels by altering plant richness and productivity, which in turn influence arthropod abundance and diversity. To examine how disturbance and nutrient addition affect arthropod communities, we established twenty 5×5 m plots on Dauphin Island, crossing mechanical disturbance with a 10 g m⁻² addition of nitrogen, phosphorus, and potassium, replicated across five experimental blocks. Arthropods were sampled using three …

Climate Science And Natural Resource Litigation, Jessica A. Wentz

Sabin Center for Climate Change Law

Climate change has major implications for sustainable use and conservation of natural resources. Many natural systems are already under severe stress and may be unable to sustain historical use patterns; resource management decisions can also exacerbate or mitigate climate change by affecting the balance of greenhouse gases in the atmosphere. This Article describes the legal and scientific basis for recognizing agencies’ obligations to assess and respond to climate change, drawing insights from a survey of U.S. litigation involving forests, fisheries, rangelands, and freshwater resources. The cases suggest litigants have been somewhat successful in driving more rigorous assessments of climate change. …

Using Scenario-Based Design Activities To Explore Sociotechnical Thinking In Engineering Professionals, James M. Whealan

Master's Theses

Sociotechnical thinking is the ability to recognize the interconnectedness of both technical and non-technical dimensions such as environmental, economic, social, cultural, and political factors. Although traditional engineering curriculum often emphasizes technical knowledge and skills, research suggests that engineering work is inherently sociotechnical. While sociotechnical thinking is a critical engineering skill, relatively little is understood about the nature of it or the different aspects comprised within it. To that end, this study addresses the following research question: What sociotechnical factors do engineering professionals consider in a collaborative scenario-based design activity? To answer this question, we conducted a qualitative study of engineering …

Probing Tau Citrullination In Alzheimer’S Disease Brains And Mouse Models Of Tauopathy, Huimin Liang, Jerry B. Hunt, Chao Ma, Andrii Kovalenko, John Calahatian, Cecelie Pedersen, Haiying Liu, Junyan Li, Malina Serrano, Danielle Blazier, Mallory Watler, Patricia Rocha-Rangel, Christopher Saunders, Laura J. Blair, Leonid Breydo, Kevin Nash, Zainuddin Quadri, Brian Kraemer, Peter Nelson, Christopher Norris, Erin L. Abner, Vladimir N. Uversky, Dale Chaput, Maj Linda B. Selenica, Daniel C. Lee

Epidemiology and Environmental Health Faculty Publications

Alzheimer’s disease (AD) includes a defining hallmark that correlates most closely to cognitive decline, namely misfolded tau protein. However, the “upstream” etiology and downstream clinical manifestations of tauopathies are quite diverse. Tau deposition elicits different pathological phenotypes and outcomes depending on the tau strain, proteoforms, and regional susceptibility. Posttranslational modifications (PTM) can alter tau structure, function, networks, and its pathological sequelae. We uncovered tau citrullination on multiple epitopes caused by peptidyl arginine deiminase (PAD) enzymes. PAD-induced citrullination irreversibly converts arginine residues to citrulline, producing a net loss of positive charge, elimination of pi–pi interactions, and increased hydrophobicity. We observed increased …

How Fundraisers Met Goals During The Covid-19 Pandemic, Cody C. Greene

Electronic Theses and Dissertations

The COVID-19 pandemic disrupted nearly every aspect of higher education operations, including fundraising and donor engagement. This qualitative study explored how Vice Presidents for Advancement and other senior fundraising leaders in higher education adapted their practices to meet fundraising goals during the pandemic. Using a narrative design, in-depth interviews were conducted with nine participants representing diverse institutions in the southeastern United States. Braun and Clarke’s (2006) six-phase thematic analysis was used to code and interpret the data.

Seven major themes emerged: communications, technology, donor relations, managing a fundraising team, overall giving impact, successful strategies, and the future. Participants described how …

Beyond Baseball: A Case Study On The Multipurpose Venue Management Practices Of Giants Enterprises, Collette Grace Madden

Experience Industry Management

The success of sports organizations no longer relies on team performance and game attendance. Giants Enterprises utilizes many guest engagement and destination development strategies to expand the brand reach of the San Francisco Giants. The purpose of this study was to examine how Giants Enterprises has positioned Oracle Park and Mission Rock as premier event destinations beyond baseball, with a focus on best practices in event diversification, experience design, and placemaking. A case study was conducted on Giants Enterprises to analyze what event diversification, experience design, and placemaking tactics were utilized as well as their effectiveness. The results of this …

Interpretive Education Stations: Keeping Terre Haute Informed, Sara E. Watson

2025 Fall Reports (Terre Haute)

Public communication of scientific findings is an important, but often neglected, part of creating solutions to environmental issues facing our communities. To address this gap, students from the ENVI 110: Introduction to Environmental Sciences class worked in small groups to design education stations to be placed around the city of Terre Haute to inform the public about topics in environmental sciences with relevance to local residents. Themes identified by ENVI 110 students for development into interpretive installations include, but are not limited to, food waste, identification of native and invasive plant and animal species, wastewater treatment, conventional and organic farming …

Identifying Climate-Appropriate Tree Species, Christy Pearison

2025 Fall Reports (Terre Haute)

The Tree Species Sustainability Symposium project was developed through a partnership between BUS 100-004 students at Indiana State University and the City of Terre Haute as part of the Sustainable Cities Program. The city’s goal for this project was to strengthen public awareness of climate-appropriate tree species, promote biodiversity, and encourage community participation in preserving Terre Haute’s award-winning urban tree canopy. Students collaborated with city and university sustainability leaders to research native tree species best suited for Terre Haute’s environment, focusing on Sycamore, Red Maple, and Eastern Redbud trees. These species were selected for their ecological benefits, resilience to climate …

Ticking Away: A Study On How Multiple Sclerosis Patients In The Us And Australia Navigate Their Day, Ella M. Stahl

Honors Theses

Multiple Sclerosis (MS) is an autoimmune disease that damages the nervous system. Individuals diagnosed with MS experience a wide variety of symptoms, the most common being fatigue and numbness in the hands and feet. This disease affects close to three million people worldwide. Current research shows that individuals with chronic conditions spend more time managing their medical issues, therefore impacting their quality of life. This study compares time use of Multiple Sclerosis patients in the US and Australia. The central investigative question is: what are the differences and similarities in time use of those diagnosed with MS in the United …

These Yellow Stars Of Ours, Vinh Hong Nguyen

Theses

These Yellow Stars of Ours is an experimental documentary that traces the intertwined histories of Thaun and Nam Nguyen as they flee war-torn Vietnam, fall in love, and build a life in Western New York. Through their accounts and those of their two sons, the film explores the complexities of generational trauma and the ongoing experience of bicultural straddling—the negotiation between inherited Vietnamese identity and the shaping influence of an American upbringing. The project examines how trauma, memory, and cultural displacement circulate across generations, shaping identity in both visible and invisible ways. Methodologically, the film is structured around the conceptual …

Mercurial, Bhavana Neti

Theses

Mercurial is a groundbreaking visual journey through typography that charts the fluid and often volatile passage, from the depths of sadness, eventually finding the light in the end, inspired by the song title Louder than Bombs by BTS, a Korean boyband. Over a carefully observed period, this book captures the subtle and dramatic transformations of emotion through a unique lens. "Mercurial" represents a unique and multi-layered approach to understanding and visualizing emotions. Initially, the exploration of shapes as a representational tool proved inadequate for capturing this complexity. This led to a pivotal shift towards typography, where the inherent qualities of …

Multiple Bursts Of Speciation In Madagascar’S Endangered Lemurs, Kathryn M. Everson, Luca Pozzi, Meredith A. Barrett, Mary E. Blair, Mariah E. Donohue, Peter M. Kappeler, Andrew C. Kitchener, Alan R. Lemmon, Emily Moriarty Lemmon, Carlos J. Pavón-Vázquez, Ute Radespiel, Blanchard Randrianambinina, Rodin M. Rasoloarison, Solofonirina Rasoloharijaona, Christian Roos, Jordi Salmona, Anne D. Yoder, Rosana Zenil-Ferguson, Dietmar Zinner, David W. Weisrock

Biology Faculty Publications

Lemurs are often cited as an example of adaptive radiation, as more than 100 extant species have evolved and filled ecological niches on Madagascar. However, recent work suggests that lemurs lack a hallmark of other adaptive radiations: explosive speciation rates that decline over time. Thus, characterizing the tempo and mode of evolution in lemurs can reveal alternative ways that hyperdiverse clades arise over time, which might differ from traditional models. We explore lemur evolution using a phylogenomic dataset with broad taxonomic sampling that includes the lorisiforms of Asia and continental Africa. Our analyses reveal multiple bursts of diversification (without subsequent …

Carbon Sequestration And Greenhouse Gas Emission Dynamics Of Forage Sorghum Cultivars In Southern Texas, Kusalika Madushani Kularathna

All Theses

Carbon sequestration is one of the major strategies for removing atmospheric carbon dioxide and fixing it in the soil and plants. The research study focused on the carbon sequestration and greenhouse gas dynamics of three different forage sorghum cultivars: Sugar Graze Ultra (annual), PSH20TX01 (perennial seeded), and PSH09TX15 (perennial rhizomes), in Southern Texas, where each cultivar had nine plots. The field study was conducted over two growing seasons, in 2024 and 2025, at the Prairie View A&M University research farm. Three different fertilizer rates, recommended, half-recommended, and zero fertilizer rates, were applied. Soil greenhouse gas emissions were measured using a …

Lynk Labs: How The Least-Vetted Documents Destroy Issued Patents, Dennis D. Crouch

Faculty Publications

The Lynk Labs petition presents the Supreme Court with an opportunity to restore the temporal coherence that Congress built into § 311(b)'s evidentiary framework. By treating "printed publication" as synonymous with any reference that eventually becomes public, the Federal Circuit has transformed IPR into a forum where unexamined, abandoned patent applications can destroy patents that survived the very scrutiny those applications failed to complete. The Court should grant certiorari and hold that a printed publication must be printed and published before the critical date to serve as the basis for an IPR challenge.

Linking Climate And Demography To Predict Population Dynamics And Persistence Under Global Change., Jennifer L. Williams, Amy L. Angert, Aldo Compagnoni, Ali Campbell, Megan L. Demarche, Margaret E K Evans, Joshua C. Fowler, Amy M. Iler, Jenna A. Loesberg, Allison M. Louthan, Scott W. Nordstrom, Multiple Additional Authors

Publications, Reports and Presentations

Predicting the effects of climate change on plant and animal populations is an urgent challenge for understanding the fate of biodiversity under global change. At the surface, quantifying how climate drives the vital rates that underlie population dynamics appears simple, yet many decisions are required to connect climate to demographic data. Competing approaches have emerged in the literature with little consensus around best practices. Here we provide a practical guide for how to best link vital rates to climate for the purposes of inference and projection of population dynamics. We first describe the sources of demographic and climate data underlying …

English Grammar Foundations, Salvatore Attardo

CHSSA Open Educational Resources (OER)

English Grammar for Undergraduate and Graduate students (Open Access)

Mass Spectrometry- And Genomic-Based Characterization Of Novel Glycosphingolipid-Producing Bacteria And Their Glycosyltransferases, Tahir Ali

Electronic Theses and Dissertations

Glycosphingolipids (GSLs) are a type of membrane-lipids commonly found in eukaryotes, as well as in bacteria from the order Sphingomonadales. In these bacteria, GSLs replace lipopolysaccharides as key structural and functional components of the outer membrane. These molecules play a crucial role in maintaining membrane integrity and helping bacteria adapt to environmental stresses. Additionally, they hold significant potential in biomedical research due to their ability to modulate the immune response through interactions with the CD1d receptor. Despite their important biological and biomedical roles, the diversity and biosynthesis of bacterial GSLs are far less understood compared to their eukaryotic counterparts. In …

The Fungal Microbiota Modulate Neonatal Oxygen-Induced Lung Injury, Isaac Martin, Mary Silverberg, Ahmed Abdelgawad, Kosuke Tanaka, Brian A. Halloran, Teodora Nicola, Erin D. Myers, Jay P. Desai, Catrina T. White, Ibrahim Karabayir, Oguz Akbilgic, Laura Tipton, Samuel J. Gentle, Namasivayam Ambalavanan, Brian M. Peters, Luan D. Vu, Viral G. Jain, Charitharth V. Lal, Stephania A. Cormier, Joseph F. Pierre, Tamás Jilling, Ajay J. Talati, Kent A. Willis

Division of Basic Science Faculty Publications

Background: The immature lungs of very preterm infants are exposed to supraphysiologic oxygen, contributing to bronchopulmonary dysplasia (BPD), a chronic lung disease that is the most common morbidity of prematurity. While the microbiota significantly influences neonatal health, the relationship between the intestinal microbiome, particularly micro-eukaryotic members such as fungi and yeast, and lung injury severity in newborns remains unknown. Results: Here, we show that the fungal microbiota modulates hyperoxia-induced lung injury severity in very low birth weight premature infants and preclinical pseudohumanized and altered fungal colonization mouse models. Instead of fungal communities dominated by Candida and Saccharomyces, the first stool …

Reinsuring Ai: Energy, Agriculture, Finance & Medicine As Precedents For Governance Of Frontier Artificial Intelligence, Nicholas Stetler

Southern Illinois University Law Journal

Federal reinsurance for advanced artificial intelligence offers a credible foundation for managing risk at scale. Traditional legal tools such as regulation, litigation, and voluntary guidelines, lack the institutional capacity to address deep uncertainty, widespread spillover effects, and low-probability but catastrophic harms. A public financial infrastructure distributes risk, incentivizes responsible development, and enables earlier detection of emerging threats. Precedent exists in nuclear energy, agriculture, healthcare, and finance, where federal reinsurance enabled markets to function despite underlying volatility. The same institutional logic applies to frontier AI.

Part I explains how general-purpose and frontier AI models work, and why they have become a …

2025 Fall Commencement, Tennessee State University

TSU Commencements 2025-Present – Mr. Dwayne Tucker, President

No abstract provided.

Sustainability Hub Newsletter - December 2025, Annaliese Santoro, Neyda Gilman, Jennifer Embree

Library Sustainability Resources

Happy wintertime Bearcats! As we enter the holiday season, consider these ideas about how to make your holidays more sustainable! Along with seed resources to grow indoors despite the cold!