Digital Commons Network^™

Eefit Landslide Inventory, Joshua N Jones, Sarah Boulton

Faculty of Science and Engineering Datasets

This co-seismic landslide inventory was mapped by Joshua Jones (AECOM) as part of the EEFIT response mission after the 6th February 2023 Karamanmaras Earthquakes and published in Boulton et al. (in review). This is not a full inventory of all features but is supplemental and additional to the published database of Gorum et al. (2023) and should be used along side this more extensive dataset.

Eefit Liquefaction Inventory, Joshua N Jones, Sarah Boulton

Faculty of Science and Engineering Datasets

A co-seismic liquefaction inventory that was mapped by Joshua Jones (AECOM) as part of the EEFIT response mission after the 6th February 2023 Karamanmaras Earthquakes and to be published in Boulton et al. (in review). This is not a full inventory of all features but is supplemental and additional to the published database of Taftsoglu et al. (2023) and should be used along side this more extensive dataset.

A Statistical Approach For Systematic Identification Of Transition Cells From Scrna-Seq Data, Yuanxin Wang, Merve Dede, Vakul Mohanty, Jinzhuang Dou, Ziyi Li, Ken Chen

Faculty, Staff and Student Publications

Decoding cellular state transitions is crucial for understanding complex biological processes in development and disease. While recent advancements in single-cell RNA sequencing (scRNA-seq) offer insights into cellular trajectories, existing tools primarily study expressional rather than regulatory state shifts. We present CellTran, a statistical approach utilizing paired-gene expression correlations to detect transition cells from scRNA-seq data without explicitly resolving gene regulatory networks. Applying our approach to various contexts, including tissue regeneration, embryonic development, preinvasive lesions, and humoral responses post-vaccination, reveals transition cells and their distinct gene expression profiles. Our study sheds light on the underlying molecular mechanisms driving cellular state transitions, …

Committee's Motion Derivative Standing Insurance

Catholic Dioceses in Bankruptcy

No abstract provided.

Coding With Those Who Show Up: Two Methodologies On Technical Committee Work, Mark E. Eaton

Publications and Research

This paper considers our library’s attempt at applying a “laissez-faire leadership” model to technical committee work. Since its introduction in the 1990s, scholarship on laissez-faire leadership has historically viewed the concept very negatively. However, we argue here that many of these perspectives are straw man arguments that do not adequately consider the possibilities of a laissez-faire model. Following some dissenting voices in the literature, we would like to reclaim the laissez-faire model as a way to facilitate library technical work under certain very specific circumstances. This paper will describe the organizational context where these laissez-faire methods worked for us. Our …

Siu Law Journal Vol 49 Fall 24 Table Of Contents

Southern Illinois University Law Journal

No abstract provided.

Dividing Up The Marital Home, Mark Strasser

Southern Illinois University Law Journal

For many marital couples, the most valuable asset at the time of divorce is the home in which they live. If that home was brought to the marriage by one of the parties and the marital community helped pay down the mortgage, the couple may disagree about whether or how much of the value of the marital home is subject to distribution at the time of divorce. Different states have adopted different approaches to the conditions under which some of the value of the marital home is subject to distribution. The approaches are designed to achieve a variety of goals …

Guy Alexander Grant

African American Funeral Programs

No abstract provided.

Enhancing Communication And Swallowing Skills In Children With Cri Du Chat Syndrome: A Comprehensive Speech Therapy Guide, Soultana Papadopoulou, Areti Anagnostopoulou, Dimitra V. Katsarou, Kalliopi Megari, Efthymia Efthymiou, Alexandros Argyriadis, Georgios Kougioumtzis, Maria Theodoratou, Maria Sofologi, Agathi Argyriadi, Efterpi Pavlidou, Eugenia I. Toki

All Works

Background: A specific deletion on the short arm of chromosome 5 (5p) is the hallmark of the rare genetic syndrome called Cri du Chat Syndrome (CdCS). It causes severe difficulty with swallowing, speech, motor skills, and cognitive deficiencies. These arise from characteristic laryngeal abnormalities and oral–motor dysfunctions. Objective: This study aims to investigate the effectiveness of speech and language intervention in addressing the multifaceted challenges of CdCS, including speech and language impairments, feeding difficulties, and social communication deficits. Methods: A narrative review was conducted to synthesize existing studies from the last 35 years on therapeutic interventions for individuals with CdCS. …

Portraits Of Agency And Power: Exploring Andean Women In Guamán Poma's Chronicle, Ruby Sygar

University Honors Theses

This study explores the depictions of women in Felipe Guamán Poma de Ayala’s chronicle titled, El primer nueva crónica y buen gobierno. By concentrating on six distinct portraits within this manuscript, the findings intend to reveal the themes, differences, and symbolic meanings that characterize and differentiate these representations. The analysis delves into how these portrayals provide insights into the roles, status, and societal perceptions of women in Inca society during the colonial period. The situation of these depictions within the general context of gender and colonialism in Andean society aims to showcase how nobleman Guamán Poma’s work critiques and …

Short-Term Territoriality: The Influence Of Time And Gender On Territorial Behavior, Audra Kooi, Celia Vander Woude, Elijah Vander Woude

Student Work

Territoriality, the behavior of claiming and defending space or objects, has been widely studied in both animal and human contexts, but most research focuses on long-term patterns. Forty-seven undergraduate students were instructed to sit and watch videos of varying lengths. After leaving the room, participants were instructed to sit again, and their seat choices were recorded to assess territorial behavior, measured by displacement. Results showed a strong preference for returning to the same seat, which suggests territorial behavior is not exclusively established in the long term but can emerge within a few minutes.

Patient-Reported Functional Outcomes And Treatment-Related Regret In Hispanic And Spanish-Speaking Men Following Prostate Cancer Treatment, Andrea A. Lopez, Bashir Al Awamlh, Li-Ching Huang, Zhiguo Zhao, Tatsuki Koyama, Karen E. Hoffman, Christopher J. Wallis, Kerri Cavanaugh, Ruchika Talwar, Alicia K. Morgans, Michael Goodman, Ann S. Hamilton, Xiao-Cheng Wu, Jie Li, Brock B. O'Neil, David F. Penson, Daniel A. Barocas

School of Public Health Faculty Publications

OBJECTIVES: Compare functional outcomes and treatment-related regret over 10 years in Spanish- and English-speaking Hispanic men compared to non-Hispanic men following treatment of localized prostate cancer. METHODS AND MATERIALS: Data from a prospective cohort study of men with localized prostate cancer treated with active surveillance, radical prostatectomy or radiotherapy were used to examine the effect of survey language (Spanish speaking vs. English speaking) and ethnicity (Hispanic vs. non-Hispanic) on functional outcomes and treatment-related regret over 10 years. Outcomes were measured using validated questionaries adjusting for baseline patient and disease characteristics. RESULTS: A total of 770 men were included, 12% were …

Jessy Mckee And Shayne Mackee, Appellants V. Clayton Mckeachine, Carolyn Harns, G&C Servi Es Inc., And Irene Mckee, Appellees : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the Order of Permanent Appointment of Limited Guardian and Full Conservator of Incapacitated Persons entered on August 10, 2023 by the Honorable Gregory Lamb, Eighth Judicial District Court, in and for Uintah County, State of Utah, Case No. 21380083.

Alan Dunaway, Attorney for Appellant, Clayton Mckeachnie, Pro Se Appellee, Kurt D. Reber, Attorneys for Appellee G&C Services, Inc

Kenneth J. Melrose, Attorney for Appellee Irene McKee, Deborah R. Chandler, Attorney for Christine DeLambert

Arnold J. Schmit Appellant V. Joshua Schmith Appellee : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from the State of Utah Third District Court – Salt Lake County The Honorable Teresa L. Welch

Rich Willie, David H. Culmer, Attorneys for Appellants

Ben W. Lieberman, Attorneys for Appellee

The Power Of Love And Authenticity: Building Resistance In The World, Arianna Silva

Undergraduate Honors Theses

Love is often described as something we “need,” perhaps because of its deep connection to the authenticity of self. Authenticity, in existentialist terms, is achieved when we discover a true sense of purpose and meaning—one that we create for ourselves. As existentialism posits that existence precedes essence. Thus,we are responsible for shaping who we are and crafting our own path in life. The relationship between love and authenticity is transformative, helping us resist oppressive systems by fostering individuality and preventing homogenization. This individuality makes it harder for authoritarian regimes to control us, as we no longer conform to societal norms …

How Can Faith Based Nonprofits Acquire And Retain New Donors From Generation Z?, Mariana Combariza

Undergraduate Honors Theses

Faith-based nonprofits, such as World Vision or Compassion International, are aware that their primary donor demographic is aging. As such, they face pressure to engage younger generations who will likely become their future financial supporters in order for their nonprofit work to be sustained. Although multiple qualitative studies have demonstrated the interest and desire that Generation Z has to donate to causes they believe in, further research is needed to understand their donation behavior and how it correlates to nonprofits’ marketing strategies. In this study, we use quantitative and qualitative data from over 243 randomly selected Gen Z college students …

Correlation Of Genogroup I, Genotype 1 (Gi.1) Norovirus Neutralizing Antibody Levels With Gi.1 Histo-Blood Group Antigen-Blocking Antibody Levels, Robert L Atmar, Khalil Ettayebi, Frederick H Neill, Ralph P Braun, James Sherwood, Sasirekha Ramani, Mary K Estes

Faculty, Staff and Students Publications

Background: The in vitro cultivation of human noroviruses allows a comparison of antibody levels measured in neutralization and histo-blood group antigen (HBGA)-blocking assays.

Methods: Serum samples collected during the evaluation of an investigational norovirus vaccine (HIL-214 [formerly TAK-214]) were assayed for neutralizing antibody levels against the vaccine's prototype Norwalk virus/genogroup I, genotype 1 (GI.1) (P1) virus strain. Results were compared with those previously determined using HBGA-blocking assays.

Results: Neutralizing antibody seroresponses were observed in 83% of 24 vaccinated adults, and antibody levels were highly correlated (r = 0.81; P < .001) with those measured by HBGA blocking.

Conclusions: Genogroup I, genotype 1 (GI.1)-specific HBGA-blocking antibodies are a surrogate …

Feasibility Of A Low-Intensity Intervention To Influence Antibiotic Prescribing Rates Use In Outpatient Settings: A Cluster Randomized Controlled Clinical Trial, Brigid M. Wilson, Sunah Song, Robin L.P. Jump, Federico Perez

Faculty Scholarship

Background. Primary care providers (PCPs) may modify their antibiotic prescription practices if aware of their potentially damaging impact. Methods. We conducted a cluster randomized controlled trial at 12 Veterans Affairs community-based outpatient clinics. PCPs at clinics randomized to the intervention group received quarterly antibiotic use reports with feedback about antibiotics prescribed for acute respiratory infections and adverse event letters alerting about Clostridioides difficile infection or antibiotic-resistant gram-negative bacteria among their patients. The main outcome, antibiotic prescriptions in primary care visits, was compared in the preintervention (April–September 2020), intervention (October 2020 to September 2021), and postintervention periods (September 2021 to September …

Identification Of An Early Subset Of Cerebellar Nuclei Neurons In Mice, Maryam Rahimi-Balaei, Shayan Amiri, Thomas Lamonerie, Sih-Rong Wu, Huda Y Zoghbi, G Giacomo Consalez, Daniel Goldowitz, Hassan Marzban

Duncan NRI Faculty and Staff Publications

Cerebellar nuclei (CN) neurons serve as the primary output of the cerebellum and originate from the cerebellar primordium at early stages of cerebellar development. These neurons are diverse, integrating information from the cerebellar cortex and relaying it to various brain regions. Employing various methodologies, we have characterized a specific subset of CN neurons that do not originate from the rhombic lip or ventricular zone of the cerebellar primordium. Embryos were collected at early stages of development and processed for immunohistochemistry (IHC), western blotting, in situ hybridization (ISH), embryonic culture, DiI labeling, and flow cytometry analysis (FCM). Our findings indicate that …

Pharmacologic Blockade Of A Pioneer Transcription Factor, Katerina Cermakova, H Courtney Hodges

Faculty, Staff and Students Publications

Cancers frequently co-opt lineage-specific transcription factors (TF) utilized in normal development to sustain proliferation. However, the effects of these TFs on tumor development depend considerably on where in the genome they bind. A new article by Taylor and colleagues expands on previously developed diamidine compounds that obstruct the DNA binding sites of the pioneer TF PU.1 (SPI1) in acute myeloid leukemia. Immobilization and sequencing of genomic DNA targeted by these compounds revealed that these inhibitors alter the genomic binding patterns of PU.1. The authors report that their strategy constrains the genomic binding preferences of PU.1, leading to redistribution of PU.1 …

Whispers In The Wind: Face Mask Sampling For Mycobacterium Tuberculosis Detection In Children With Pulmonary Tuberculosis, Lennard Meiwes, Irina Kontsevaya, Dumitru Chesov, Stela Kulciţkaia, Viola Dreyer, Doris Hillemann, Qiniso Dlamini, Caroline Williams, Michael Barer, Folke Brinkmann, Renate Krüger, Stephanie Thee, Alexander Kay, Anna Maria Mandalakas, Christoph Lange

Faculty, Staff and Students Publications

Background: Recently, face mask sampling (FMS) confirmed detection of Mycobacterium tuberculosis DNA from exhaled breath in adults with tuberculosis. To date, no study has evaluated the use of FMS to detect pulmonary tuberculosis in children. We developed a method for FMS of M. tuberculosis-specific DNA in children and performed a clinical exploration to assess feasibility in children.

Methods: Face masks were spiked, analyzed on GeneXpert-Ultra, quantitative polymerase chain reaction, and targeted next-generation sequencing. Children with pulmonary tuberculosis were asked to wear 3 modified FFP2 masks for 30 minutes as part of an exploratory clinical study.

Results: Experiments with H37Ra M. …

Cutaneous Nodules Secondary To Mycobacterium Avium Complex In A Patient With Human Immunodeficiency Virus, Jay Patel, Shannon Sayyadioskoie, Hanna Siatecka, Theodore Rosen

Faculty, Staff and Students Publications

We present a patient with human immunodeficiency virus who developed multiple painful lesions that previously in the past had speciated as Cryptococcus neoformans cutaneously, and in the lung. Despite induction therapy for presumed re-infection, the patient did not improve so a biopsy was performed and this was speciated as Mycobacterium avium complex, with final diagnosis being disseminated Mycobacterium avium complex. This case highlights the importance of considering a broad differential diagnosis for any new lesions regardless of prior culture data.

Improving Health And Well-Being Through Shared Family Meals, Halle Larson, Savannah Daines, Stacy Bevan, Palak Gupta, Mateja R. Savoie-Roskos

All Current Publications

Shared family meals provide numerous benefits for children, adolescents, and parents, including improved diet quality, healthier weight, better academic performance, stronger family bonds, and enhanced mental health. Regular family meals help children develop healthier eating habits, reduce risky behaviors, and foster communication skills. Despite challenges such as busy schedules and differing dietary preferences, families can overcome obstacles by starting small, keeping meals simple, involving everyone in meal prep, and minimizing distractions like screens. Creating a positive, flexible mealtime routine can help integrate these valuable moments into family life.

Development Of A Ripk1 Degrader To Enhance Antitumor Immunity, Xin Yu, Dong Lu, Xiaoli Qi, Rishi Ram Paudel, Hanfeng Lin, Bryan L Holloman, Feng Jin, Longyong Xu, Lang Ding, Weiyi Peng, Meng C Wang, Xi Chen, Jin Wang

Faculty, Staff and Students Publications

The scaffolding function of receptor interacting protein kinase 1 (RIPK1) confers intrinsic and extrinsic resistance to immune checkpoint blockades (ICBs) and emerges as a promising target for improving cancer immunotherapies. To address the challenge posed by a poorly defined binding pocket within the intermediate domain of RIPK1, here we harness proteolysis targeting chimera (PROTAC) technology to develop a RIPK1 degrader, LD4172. LD4172 exhibits potent and selective RIPK1 degradation both in vitro and in vivo. Degradation of RIPK1 by LD4172 triggers immunogenic cell death, enhances tumor-infiltrating lymphocyte responses, and sensitizes tumors to anti-PD1 therapy in female C57BL/6J mice. This work reports …

Pediatric Flecainide Pharmacogenomics: A Roadmap To Delivering Precision-Based Care To Pediatrics Arrhythmias., Ronald Palmen, Mollie Walton, Jonathan B. Wagner

Manuscripts, Articles, Book Chapters and Other Papers

Flecainide acetate is a Class 1c anti-arrhythmic with a potent sodium voltage gated channel blockade which is utilized for the second-line treatment of tachyarrhythmias in children and adults. Given its narrow therapeutic index, the individualization of drug therapy is of utmost importance for clinicians. Despite efforts to improve anti-arrhythmic drug therapy, there remain knowledge gaps regarding the impact of variation in the genes relevant to flecainide's disposition and response. This variability is compounded in developing children whose drug disposition and response pathways may remain immature. The purpose of this comprehensive review is to outline flecainide's disposition and response pathways while …

The Comparative Effect Of Propolis And Chlorhexidine Mouthwash On Oral Nitrite-Producing Bacteria And Blood Pressure Regulation, R. Bescos, L. Du Toit, A. Redondo-Rio, P. J. Warburton, T. L. Nicholas, M. Kiernan, R. A. Burton, L. Belfield, G. Montagut, A. Benavente, W. Vevers, T. Gabaldón, Z. Brookes, P. Casas-Agustench

School of Health Professions

BACKGROUND: Propolis mouthwash (PROP-M) has demonstrated antibacterial properties like those of chlorhexidine mouthwash (CHX-M). However, its impact on the abundance of oral nitrite-producing species (NPS) and nitrite-producing activity (NPA) remains unexplored.

METHODS: Forty-five healthy individuals were randomised into 2 groups to rinse their mouth twice a day for seven days with either CHX-M ( n  = 21) or PROP-M ( n  = 24). Metagenomic sequencing (16S rRNA) was performed on saliva samples collected before and after each treatment. Additionally, salivary biomarkers and blood pressure were measured.

RESULTS: CHX-M increased the relative abundance of NPS ( p  < 0.001) but significantly impaired the NPA ( p  < 0.001) compared to baseline and PROP-M. No significant differences in the relative abundance of NPS and NPA were observed in the PROP-M group. However, a significant increase of plasma nitrate (+7 µmol/L, p  = 0.047) and a decrease in systolic BP (-2 mmHg, p  = 0.022) was observed in this group compared to the baseline.

CONCLUSION: The results indicate …

Microstructure Analysis Of Different Naoh Molarity Towards Fly Ash Geopolymer For Underwater Concreting Material, F. H.A. Zaidi, A. Romisuhani, M. M.A.B. Abdullah, W. M.W. Ibrahim, M. I.A. Bistamam, A. S. Sauffi, L. Y. Li

School of Engineering, Computing and Mathematics

Geopolymer concrete is a new sustainable and environmentally friendly composite with great potential to replace conventional concrete that is mostly produced by ordinary Portland cement (OPC). Binders used for geopolymer concrete such as fly ash and blast furnaces are mostly industrial wastes or by -products containing high silica and aluminium content that act as stimulants for geopolymerization. Furthermore, geopolymers also exhibit better durability and corrosion resistance than OPCs. However, material subjected to underwater placement method typically exhibit a decrease in properties. While geopolymer has not been widely used as underwater concreting material, this research is purposed to identify the effect …

‘En Shaddud: Elemental Composition Of Two Metal Weapons, Yonah Maor, Yotam Asscher

Qadum: Journal of Excavation Reports from Israel

The elemental composition of two weapons from Middle Bronze Age I burials at Tel Shaddud was analyzed by X-ray fluorescence. Both the spearhead and the ‘duckbill’ axe head were arsenic-copper alloys but differed in their minor components. The axe head contained more lead, probably added to improve casting properties due to its complicated shape. The spearhead contained iron as a minor component.

Agcalan Point, Jose Y. Dalisay

Kritika Kultura

No abstract provided.

Interview With Jose Y.Dalisay, Daryll Delgado

Kritika Kultura

No abstract provided.