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2024

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Effects Of Juvenile Mass On Reproduction And Calf Survival In A Low-Density Moose Population, Sara R. Henslee Dec 2024

Effects Of Juvenile Mass On Reproduction And Calf Survival In A Low-Density Moose Population, Sara R. Henslee

Biological Sciences

Moose (Alces alces) are a valuable big game species in Alaska and serve as a critical food source for residents. Near Nome, Alaska, the local moose population has remained at low densities for decades, and there is strong public interest in investigating the cause behind the population's failure to increase in abundance. Compared to other moose populations in Alaska, the population of moose near Nome does not appear to be nutritionally limited or close to carrying capacity. I sought to explore how juvenile mass, a widely used metric to assess moose nutritional status in Alaska, influences reproductive output and subsequent …


Learning And Doing And Bricks Transfer, Angela Brock Dec 2024

Learning And Doing And Bricks Transfer, Angela Brock

General Education Committee

No abstract provided.


Ucc Agenda 12-17-24, Angela Brock Dec 2024

Ucc Agenda 12-17-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.


Ucc Minutes 12-17-24, Angela Brock Dec 2024

Ucc Minutes 12-17-24, Angela Brock

UCC Agendas/Minutes

No abstract provided.


How Do Anxiety, Stress, Impulsiveness, And Sleep Quality Affect Memory, Hodavia Tshiya Kaseya Dec 2024

How Do Anxiety, Stress, Impulsiveness, And Sleep Quality Affect Memory, Hodavia Tshiya Kaseya

Online Theses and Dissertations

Memory is a critical cognitive function that enables individuals to retain, recall, and apply knowledge across various contexts. Different memory systems, including working memory and long-term memory, collaborate to process and store information. Factors such as stress, sleep disturbances, anxiety, and impulsiveness can impact memory encoding and retrieval, especially in college students, whose academic success depends heavily on memory performance. This study examined the relationship between these everyday factors and memory performance by analyzing brain activity during memory encoding using Electroencephalography (EEG) and the Difference due to memory (DM) event-related potential (ERP) effect, to understand how stress, sleep, anxiety, and …


Edge Of The Wagon Wheel, William C. Mcqueen Dec 2024

Edge Of The Wagon Wheel, William C. Mcqueen

Online Theses and Dissertations

This is a satirical sci-fi novel set in the near future. Following the inadvertent melting of the ice caps, the United States splits—peacefully, like a mutual breakup—into four new countries. In an attempt to prove that the earth is flat, the Best States of America (BSA) have launched a replica of the Apollo 11 spacecraft with a child prodigy aboard, alone. Meanwhile, a disgruntled low-level government employee from the Left States of America (LSA) detects the launch with the help of his AI computer and makes contact with the BSA astronaut. The story follows everything that transpires to get Buzz …


Good For Her: Catharsis And Empowerment In Contemporary Literature, Jessica Lynn Vaught Dec 2024

Good For Her: Catharsis And Empowerment In Contemporary Literature, Jessica Lynn Vaught

Online Theses and Dissertations

A recent trend in readership within online discourse communities is the emergence of the genre called “Good for Her,” which contains themes of transgression beyond traditional expectations of socially acceptable feminine behavior by situating revenge arcs to celebrate actions that otherwise would have been perceived as reprehensible. The emergence and popularity of the genre in the post-2016 sociopolitical climate in the United States reflects the demand for marginalized communities to see versions of themselves represented in texts in which the protagonist avenges herself in the face of patriarchal oppression. The genre stems from canonical literary tropes also created in the …


Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier Dec 2024

Bat Activity Across Urban Forest Plantings In Lexington, Kentucky, Grayson Marie Collier

Online Theses and Dissertations

Urbanization has led to major forest loss and negatively impacts ecosystem services. Urban reforestation efforts, such as Reforest the Bluegrass (RTB) in the Lexington-Fayette metropolitan area of Kentucky, have been implemented to address these negative effects, and to create habitat for forest-dependent wildlife such as bats. My research focused on assessing differences in bat activity across a 20-year chronosequence of RTB sites. Acoustic detectors were deployed across 10 different-aged plantings at 60 randomly-defined detector locations. Each planting was surveyed across 8 sampling periods from May – August 2023. Each recording session spanned ca. 7 consecutive nights, yielding a total of …


An Intervention For Youth Impacted By Parental Incarceration: A Mentoring Program Effectiveness From The Caregiver’S Perspective, Sunni Sarah Iris Ann Walters Dec 2024

An Intervention For Youth Impacted By Parental Incarceration: A Mentoring Program Effectiveness From The Caregiver’S Perspective, Sunni Sarah Iris Ann Walters

Online Theses and Dissertations

This study explores the effectiveness of the Amachi mentoring program in supporting children impacted by familial incarceration from the caregivers perspective. Using a qualitative approach, we conducted two focus groups with three participants in each to assess the program's impact across four key areas: behavior, emotions, school performance, and social interactions. We hypothesized that Amachi would have a positive impact on the children they serve. The findings indicate that caregivers perceive the program as beneficial, suggesting potential improvements in various aspects of the children’s lives. These results highlight the potential of the Amachi program to support the development and resilience …


Factors Associated With First-Year Student Retention In Higher Education: A Quantitative Analysis Of Student Confidence And Use Of Support Services On Persistence And Success, Starr Wentzel Dec 2024

Factors Associated With First-Year Student Retention In Higher Education: A Quantitative Analysis Of Student Confidence And Use Of Support Services On Persistence And Success, Starr Wentzel

Online Theses and Dissertations

This quantitative study investigated factors influencing first-year student retention at a midsized regional comprehensive university. Using archival data from the 2021-2022 and 2022-2023 academic years, the research examined the retention rates of Standard Admit students and conditionally admitted Success First students. The study explored student retention based on use of available support services, namely visits to the campus Student Success Center (SSC), as well as measures of cognitive and non-cognitive skills and confidence as assessed through a standardized nationally normed assessment tool. Additionally, it identified key demographic variables such as gender, race, Pell Grant eligibility, and first-generation status that impact …


Living Pedagogy: Redesigning The First Year Writing Classroom, Ella Johnson Dec 2024

Living Pedagogy: Redesigning The First Year Writing Classroom, Ella Johnson

Online Theses and Dissertations

In this thesis the writing pedagogies of process, critical literacy, and multimodality are used as a framework for redesigning the physical layout and aesthetics of the first-year writing classroom. The idea of embracing a fully embodied ‘living’ pedagogy is also explored as a means to develop and sustain professional identity as a college writing instructor. An examination of process pedagogy reveals a natural materiality of writing and the role of physical environment. The pedagogy of critical literacy is used to determine how issues accessibility and representation can be answered by classroom design. Current practices of multimodality in classroom design are …


Pleural Empyema: Etiology And Pathogenesis, Daniel M Musher, Sherwood Gorbach, Joshua Fierer Dec 2024

Pleural Empyema: Etiology And Pathogenesis, Daniel M Musher, Sherwood Gorbach, Joshua Fierer

Faculty, Staff and Students Publications

No abstract provided.


Touching Distant Time And Place: Place-Based Augmented Reality Storytelling, Misha Myers Dec 2024

Touching Distant Time And Place: Place-Based Augmented Reality Storytelling, Misha Myers

School of Art, Design and Architecture

Storying place through augmented reality technologies, such as software and applications which enhance and encourage interaction with physical environments with digital visual and audio elements and place digital objects in specific locations, offers multisensory tactile ways of inter-mediating relationships between self and changing environments. This chapter examines and compares how four site-specific, site-responsive and site-generic augmented reality storytelling works made for smartphones augment specific living environments through augmented spatiality, immersive audio, geo-located and interactive sound and/or visually augmented three-dimensional animations of digital entities and objects. This chapter considers how the application of specific augmented technologies in each of the works …


Synthesis Of Activated Carbon From Coconut Shell And Recycled Styrofoam Nanofiber For Water Filtration, Rahma Dani, Ismet Ismet, Leni Marlina, Rona Alisya, Muhamad Abel Kirana Aldi, Anggi Ludiansyah, Lintang Auliya Kurdiati, Meutia Kamilatun Nuha Ap Idjan, Agung Mataram, Muhammad Rama Almafie, Ida Sriyanti Dec 2024

Synthesis Of Activated Carbon From Coconut Shell And Recycled Styrofoam Nanofiber For Water Filtration, Rahma Dani, Ismet Ismet, Leni Marlina, Rona Alisya, Muhamad Abel Kirana Aldi, Anggi Ludiansyah, Lintang Auliya Kurdiati, Meutia Kamilatun Nuha Ap Idjan, Agung Mataram, Muhammad Rama Almafie, Ida Sriyanti

Makara Journal of Science

Water pollution affects life sustainability; hence, several efforts have been exerted to overcome this problem. For ex-ample, nanofiber membrane technology is introduced to retain solutes while allowing only water molecules to pass through the system. Therefore, this study aimed to maximize the technology for water filtration using the electrospin-ning method by combining Styrofoam waste-based polymer with activated carbon from coconut shell waste (ACCS). The nanofiber diameter produced ranged from 590 nm to 610 nm with porous characteristics and without beads. The carbon content varied from 68.04% to 69.84%, according to the energy dispersive X-ray measurement, demonstrating the composite’s effectiveness. The …


Evaluation Of An Artificial Intelligence-Based Intraocular Lens Calculator: Ai-Based Iol-Optimized Formula, Li Wang, Hendrik Burwinkel, Nicolas Bensaid, Douglas D Koch Dec 2024

Evaluation Of An Artificial Intelligence-Based Intraocular Lens Calculator: Ai-Based Iol-Optimized Formula, Li Wang, Hendrik Burwinkel, Nicolas Bensaid, Douglas D Koch

Faculty, Staff and Students Publications

Purpose: To evaluate the ZEISS AI IOL Calculator (ZEISS AI) and compare its accuracy in refractive prediction to the Barrett Universal II (BUII) and Kane formulas.

Setting: Cullen Eye Institute, Baylor College of Medicine, Houston, TX.

Design: Retrospective case series.

Methods: The ZEISS AI IOL Calculator (ZEISS AI) is an artificial intelligence (AI) based IOL-optimized formula. The refractive prediction errors (PEs) were calculated in the entire dataset and subgroups of short eyes (axial length (AL) ≤ 22.5 mm) and long eyes (AL ≥ 25.0 mm). The standard deviation (SD), root-mean-square absolute error (RMSAE), mean absolute error (MAE), median absolute error …


Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni Dec 2024

Uba1 Inhibition Sensitizes Cancer Cells To Parp Inhibitors, Sharad Awasthi, Lacey E Dobrolecki, Christina Sallas, Xudong Zhang, Yang Li, Sima Khazaei, Sumanta Ghosh, Collene R Jeter, Jinsong Liu, Gordon B Mills, Shannon N Westin, Michael T Lewis, Weiyi Peng, Anil K Sood, Timothy A Yap, S Stephen Yi, Daniel J Mcgrail, Nidhi Sahni

Faculty, Staff and Students Publications

Therapeutic strategies targeting the DNA damage response, such as poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi), have revolutionized cancer treatment in tumors deficient in homologous recombination (HR). However, overcoming innate and acquired resistance to PARPi remains a significant challenge. Here, we employ a genome-wide CRISPR knockout screen and discover that the depletion of ubiquitin-activating enzyme E1 (UBA1) enhances sensitivity to PARPi in HR-proficient ovarian cancer cells. We show that silencing or pharmacological inhibition of UBA1 sensitizes multiple cell lines and organoid models to PARPi. Mechanistic studies uncover that UBA1 inhibition not only impedes HR repair to sensitize cells to PARP inhibition …


Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia Dec 2024

Large-Scale Crispr/Cas9 Deletions Within The Wfdc Gene Cluster Uncover Gene Functionality And Critical Roles In Mammalian Reproduction, Katarzyna Kent, Kaori Nozawa, Rachel Parkes, Laura Dean, Frey Daniel, Mei Leng, Antrix Jain, Anna Malovannaya, Martin M Matzuk, Thomas X Garcia

Faculty, Staff and Students Publications

Despite 96 million years of evolution separating humans and rodents, 11 closely related reproductive tract-specific genes in humans—SPINT3, WFDC6, EPPIN, WFDC8, WFDC9, WFDC10A, WFDC11, WFDC10B, WFDC13, SPINT4, and WFDC3—and the 13 reproductive tract-specific orthologous genes in mice, form highly conserved syntenic gene clusters indicative of conserved, combined critical functions. Further, despite significant progress toward a nonhormonal male contraceptive targeting the protein encoded by one of these genes, epididymal peptidase inhibitor (EPPIN), and associations found between mutations in EPPIN and an increased risk of male infertility, neither EPPIN nor …


Skin Lesions, Weight Loss, And Facial Swelling After A Hand Injury, Yuriko Fukuta, Cindy Qinyang Wu, Todd Michael Lasco, Abdul Hafeez Diwan Dec 2024

Skin Lesions, Weight Loss, And Facial Swelling After A Hand Injury, Yuriko Fukuta, Cindy Qinyang Wu, Todd Michael Lasco, Abdul Hafeez Diwan

Faculty, Staff and Students Publications

No abstract provided.


The C-Terminal Activating Domain Promotes Pannexin 1 Channel Opening, Erik Henze, Jacqueline J Ehrlich, Janice L Robertson, Eric Gelsleichter, Toshimitsu Kawate Dec 2024

The C-Terminal Activating Domain Promotes Pannexin 1 Channel Opening, Erik Henze, Jacqueline J Ehrlich, Janice L Robertson, Eric Gelsleichter, Toshimitsu Kawate

2020-Current year OA Pubs

Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of the Panx1 channel by unplugging the pore. However, this simple pore-plugging mechanism alone cannot account for the observation that a Panx1 construct ending before the caspase cleavage site remains closed. Here, we show that a helical region located immediately before the caspase cleavage site, referred to as the "C-terminal activating domain (CAD)", plays a pivotal role in facilitating Panx1 activation. Electrophysiology and mutagenesis studies uncovered that two conserved …


Conventional Cytogenetic Analysis Of Solid Tumor Abnormalities: A 25-Year Review Of Proficiency Test Results From The College Of American Pathologists/American College Of Medical Genetics And Genomics Cytogenetics Committee, Rachel K Vanderscheldon, Yang Cao, Et Al. Dec 2024

Conventional Cytogenetic Analysis Of Solid Tumor Abnormalities: A 25-Year Review Of Proficiency Test Results From The College Of American Pathologists/American College Of Medical Genetics And Genomics Cytogenetics Committee, Rachel K Vanderscheldon, Yang Cao, Et Al.

2020-Current year OA Pubs

No abstract provided.


Nasopharyngeal Amelanotic Melanoma In Cat; A Case Report, Chutirat Torsahakul, Sujittra Thaipradist Dec 2024

Nasopharyngeal Amelanotic Melanoma In Cat; A Case Report, Chutirat Torsahakul, Sujittra Thaipradist

The Thai Journal of Veterinary Medicine

A 10-year-old sterilized female DSH cat was referred to the Small Animal Teaching Hospital (SATH), Faculty of Veterinary Science, Chulalongkorn University for diagnosis and treatment. She was quiet, alert, and responsive (QAR) and had a normal appetite. The clinical sign of upper respiratory distress with stridor had been presented for more than three months. Computed tomography (CT) and radiography examination were used for diagnosis, and the results showed a soft tissue mass in the nasopharyngeal region. The morphology and position of the nasopharyngeal mass were demonstrated by retrograde rhinoscopy, which was underwent a biopsy simultaneously. Histopathological examination indicated an amelanotic …


The Effects Of Dietary Level Of Mulberry Leaf Powder On Growth Performance, Carcass Yields, And Some Serum Lipid Levels In Pradu-Hang-Dam Chickens During Cool And Rainy Seasons, Sarawanee Khunmanee, Thuwanon Boonkerd, Thananon Junsuri, Winai Kaewlamun, Pachara Pearodwong, Kajohn Nitiwararak Dec 2024

The Effects Of Dietary Level Of Mulberry Leaf Powder On Growth Performance, Carcass Yields, And Some Serum Lipid Levels In Pradu-Hang-Dam Chickens During Cool And Rainy Seasons, Sarawanee Khunmanee, Thuwanon Boonkerd, Thananon Junsuri, Winai Kaewlamun, Pachara Pearodwong, Kajohn Nitiwararak

The Thai Journal of Veterinary Medicine

This study aimed to determine the optimal concentration of mulberry leaf powder (MLP) supplementation and to evaluate the impact of different seasons on the growth performance, carcass characteristics, and blood lipid levels of Pradu-Hang-Dam chickens. One-week-old chickens were assigned to three groups: a control group (without MLP) and two groups receiving diets supplemented with 0.5% and 1.5% MLP, respectively, over a 10-week period. The results indicated that during the cool season, the control group exhibited the highest feed intake, average daily gain, and superior carcass characteristics (P < 0.05). In the rainy season, chickens supplemented with 1.5% MLP achieved the highest feed intake, while those supplemented with 0.5% MLP showed the highest average daily gain and the lowest feed conversion ratio (P < 0.05). Furthermore, the 1.5% MLP group demonstrated superior carcass characteristics compared to the control group during the rainy season (P < 0.05). Analysis of blood lipid metabolism revealed that the group supplemented with 0.5% MLP during the cool season had the lowest levels of triglycerides, cholesterol, and high-density lipoprotein. In conclusion, the cool season is the most favorable for raising Pradu-Hang-Dam chickens in Thailand. Additionally, supplementing diets with at least 0.5% MLP during the rainy season can improve growth performance, carcass characteristics, and blood parameters.


Presence Of The Ade Multidrug Systems And Response To Triclosan Exposure In Acinetobacter Baumannii From Animal Origins, Sirawit Pagdepanichkit, Rungtip Chuanchuen Dec 2024

Presence Of The Ade Multidrug Systems And Response To Triclosan Exposure In Acinetobacter Baumannii From Animal Origins, Sirawit Pagdepanichkit, Rungtip Chuanchuen

The Thai Journal of Veterinary Medicine

Thirty Acinetobacter baumannii from animal origins were obtained from 210 animal carcasses submitted for post-mortem examination, including dogs (n=112), cats (n=45), rabbits (n=17), birds (n=15), pigs (n=7) and exotic animals (n=14). All the isolates were evaluated for antimicrobial susceptibility with absence and presence of efflux inhibitors i.e. reserpine and carbonyl cyanide m-chlorophenylhydrazone (CCCP) and expression profile of important six multidrug efflux systems (i.e. AdeABC, AdeDE, AdeFGH, AdeIJK, AbeM and AmvA). Fifteen isolates expressing different Ade multidrug efflux pumps were selected for determining transcription levels and regulatory mutations. A continuous in vitro exposure experiment with benzalkonium chloride, chlorhexidine and triclosan …


Exploring The Major Watershed Basins All Around The World: A Meta-Analysis For Basins Characteristics, Saad Mohammad Qurishi Dec 2024

Exploring The Major Watershed Basins All Around The World: A Meta-Analysis For Basins Characteristics, Saad Mohammad Qurishi

AUIQ Technical Engineering Science

Analysis of major watershed basins in a global vision provides a crucial information on sustainable management of water resource throughout the Earth. In this review, a globally significant watersheds were reviewed including the Murray-Darling Basin (Australia), Yangtze River basin (Asia), Volga River Basin (Europe), Nile River Basin (Africa), Hudson Bay Watershed & Mississippi Basin (Canada/North America), and the Amazon Basin (South America). A detailed overview was performed on emphasizing climate, agriculture, hydrology, groundwater, and ecological aspects of the watershed basins, providing holistic knowledge in terms of their environmental and socio-economic impacts. This review explores the challenges which are encountered by …


Development Of A Hybrid Intelligence Algorithm To Estimate The Derivative Weight Of Dawakin Tofa Clay For Heat Storage, Abubakar D. Maiwada, Abdullahi A. Adamu, Umar D. Maiwada, Sani I. Abba Dec 2024

Development Of A Hybrid Intelligence Algorithm To Estimate The Derivative Weight Of Dawakin Tofa Clay For Heat Storage, Abubakar D. Maiwada, Abdullahi A. Adamu, Umar D. Maiwada, Sani I. Abba

AUIQ Technical Engineering Science

The accurate prediction of thermogravimetric properties is critical for evaluating the suitability of natural materials like Dawakin Tofa clay for heat storage applications, but traditional linear models often fail to capture the complex, non-linear relationships inherent in such datasets. This study develops a hybrid intelligence framework integrating Bilateral Neural Network (BNN), Kernel Support Vector Machine (KSVM), Step-Wise Linear Regression (SWLR), and Robust Linear Regression (RLR) to predict the derivative weight of Dawakin Tofa clay based on 5,030 experimentally obtained instances. Comprehensive data preprocessing, including normalization, feature selection, and dataset splitting (80% training and 20% testing), ensured high-quality inputs for the …


Design And Implementation Of A 3d Laser Printer For Scientific Purposes, Zainab Hameed Neamah Dec 2024

Design And Implementation Of A 3d Laser Printer For Scientific Purposes, Zainab Hameed Neamah

AUIQ Technical Engineering Science

In recent years, the demand for efficient and cost-effective 3D printing technology has surged, opening up a plethora of potential applications across various industries. One promising solution is the design and implementation of a 3D printer utilizing PLA (Polylactic Acid) filament, an eco-friendly and biodegradable material. This approach not only promotes sustainability but also offers a reliable printing system for creating accurate 3D models. By harnessing the power of this innovative technology, users can effectively capture complex geometries and intricate details, ultimately revolutionizing the way we perceive and interact with the physical world around us. In this work, the design …


Thermal Imaging Based Solutions For Implementing Platform Management In Networking/Server Equipment, Hari Pillai, Phong Ho, Stephen A Scearce, Lauren A Marino Dec 2024

Thermal Imaging Based Solutions For Implementing Platform Management In Networking/Server Equipment, Hari Pillai, Phong Ho, Stephen A Scearce, Lauren A Marino

Defensive Publications Series

Existing systems for internal monitoring of networking/server equipment are not scaling to meet the needs of the next generation of electronic system issues. Current solutions for internal monitoring only provide a limited amount of information that leaves gaps in the understanding of the condition and integrity of the networking products. To overcome these issues, proposed herein are techniques that leverage real time infrared (IR) monitoring to quickly detect intrusive events, thermal complications, corrosion, and dust accumulation before damage to the networking products or customers occur.


Quantum Computing For Health And Financial Decision-Making: Empowering Employees To Improve Life And Finance, Ramkumar Bharathan Dec 2024

Quantum Computing For Health And Financial Decision-Making: Empowering Employees To Improve Life And Finance, Ramkumar Bharathan

Defensive Publications Series

Quantum computing offers a paradigm shift in computational power with the potential to revolutionize employee well-being and financial security. This paper explores the application of quantum algorithms, including VQE, QAOA, and QMC, in personalized healthcare, optimized financial planning, and advanced organizational resource allocation. We discuss the computational advantages of these algorithms over classical methods, address challenges of the NISQ era, and propose future research directions for realizing quantum advantage in enhancing employee lives.


Center Curtain Airbag, Matt Shaheen, Zf-Lifetec Dec 2024

Center Curtain Airbag, Matt Shaheen, Zf-Lifetec

Defensive Publications Series

A center-mounted curtain airbag implements a zig-zag fold that produces linear deployment of the airbag between occupants seated in a vehicle row of seating.


Marine Microplastics Database, Andrew Allegra Dec 2024

Marine Microplastics Database, Andrew Allegra

Benefits of Ocean Observing Catalog (BOOC)

Global data about microplastics (less than 5 millimeters in length) have been provided by contributors from various research cruises and fieldwork around the globe for integration into this database. These data are difficult and expensive to obtain. All sources of data and information are needed in order to complete a comprehensive understanding of the challenges going forward.