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Articles 2191 - 2220 of 192930
Full-Text Articles in Entire DC Network
Editorial Volume 52 No. 4, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Editorial Volume 52 No. 4, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Journal of Education Studies
No abstract provided.
Contents Volume 52 No. 4, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Contents Volume 52 No. 4, ศูนย์นวัตกรรมทางการศึกษา สื่อสิ่งพิมพ์ และสื่อออนไลน์ จุฬาฯ
Journal of Education Studies
No abstract provided.
Micro: Bit A Tool For Learning And Innovation In The Digital Economy, Jarupa Kitcharoenpanya, Pongprapan Pongsophon, Ekgapoom Jantarakantee
Micro: Bit A Tool For Learning And Innovation In The Digital Economy, Jarupa Kitcharoenpanya, Pongprapan Pongsophon, Ekgapoom Jantarakantee
Journal of Education Studies
Micro: bit, a compact computing device, has become a vital tool for learning and innovation in the digital economy era, where economic systems are driven by digital technologies, including the use of the internet. This academic article elucidates the diverse role of the Micro: bit in education and the cultivation of essential skills for students in the context of the rapidly advancing digital landscape. The Micro: bit is utilized as a foundation for teaching coding, basic programming, and developing computational skills for students due to its user-friendly nature, compact design, and affordability. This device facilitates exploration of the technology world …
Effects Of Active Learning In Physics Experiments On Academic Achievement, Attitudes And Concepts Among Grade-11 Students, Kittikhun Seawsakul
Effects Of Active Learning In Physics Experiments On Academic Achievement, Attitudes And Concepts Among Grade-11 Students, Kittikhun Seawsakul
Journal of Education Studies
One of the problems in learning physics is students’ attitudes. Most students think that physics is difficult to learn and to understand. This causes students' motivation and attitudes of curiosity towards the physics subject to decrease. The objectives of this work were to investigate students' attitudes towards physics and physics concepts, as well as to compare the academic achievement of the sample group before and after studying the lessons based on active learning through physics experiments. The sample group in this study consisted of 31 Grade 11 students, and data collection was conducted over the course of one semester. Data …
Graduate Competencies Under The Thai Qualifications Framework For Higher Education In Educational Administration, Sumet Ngamkanok
Graduate Competencies Under The Thai Qualifications Framework For Higher Education In Educational Administration, Sumet Ngamkanok
Journal of Education Studies
This research aimed to 1) study graduate competencies under the Thai Qualifications Framework for higher education in educational administration; 2) develop indicators for developing graduate competency for higher education in educational administration, 3) create a competency development manual for graduates under the Thai qualifications framework for higher education in educational administration. Research instruments included a semi-structured interview form for collecting data and experts interview conclusions to develop indicators and create the questionnaire for evaluation and focus group. There were three stages of the research procedures: 1) studying competency components of graduates under the Thai Qualifications Framework in educational administration; 2) …
The Needs For Developing High-Efficiency Learning Management In The Digital Era, Kanchit Pimjai, Duangkamol Traiwichitkhun
The Needs For Developing High-Efficiency Learning Management In The Digital Era, Kanchit Pimjai, Duangkamol Traiwichitkhun
Journal of Education Studies
This research aims to 1) study the conceptual framework for high-efficiency learning management in the digital era, and 2) investigate the needs for developing high-efficiency learning management in the digital era. The study employs a mixed-methods research design divided into two phases. Phase 1 involves qualitative research to address the conceptual framework for high-efficiency learning management in the digital era, with data collected from four selected experts using purposive sampling. The research tool was an interview guide, and the qualitative data was analyzed through content analysis, categorization, and summarization of findings. Phase 2 involves quantitative research to address the needs …
Reform Of Laboratory Courses Teaching In Higher Education To Enhance Sustainability In The Post Covid-19 Era, Bin Zhu, Simin Xing
Reform Of Laboratory Courses Teaching In Higher Education To Enhance Sustainability In The Post Covid-19 Era, Bin Zhu, Simin Xing
Journal of Education Studies
The COVID-19 pandemic has brought many difficulties and challenges to laboratory courses, but also promoted the development and prosperity of various teaching methods and made the position of laboratory instruction in higher education contemplated deeply. On the other hand, the monotonous and constant teaching materials and the formalized and theorized examination form have resulted in students' inertia and perfunctory attitude toward the experiment learning. Facing unpredictable futures and students' indifferent mentality, we urgently need to redesign the curriculum to enhance flexibility and resilience, meanwhile, ameliorate educational achievements. It is an important guiding principle of curriculum design to utilize diversified teaching …
E-Adviser Neu: Good Practice For Monitoring, Controlling And Consulting Dissertation Development Of Graduate Students In Curriculum And Instruction Program, Santi Wijakkanalan, Somsong Sitthi
E-Adviser Neu: Good Practice For Monitoring, Controlling And Consulting Dissertation Development Of Graduate Students In Curriculum And Instruction Program, Santi Wijakkanalan, Somsong Sitthi
Journal of Education Studies
The development of the dissertation of graduates in curriculum and instruction program at Northeastern University is essential and necessary as it is considered evidence of their potential and effort and also an index indicator of the quality of graduate education. Additionally, it is necessary for the process of dissertation development to be systematic with acceptable standards. e-Advisor NEU is an application of information technology of monitoring, controlling, and consulting about the development of dissertation which comprises of a system for students, advisors, and a defense committee. Students can send their dissertation reports to their advisors and receive feedback from them …
A Study Of The Impact Of Covid-19 On Developmental Decline And Learning Loss In Young Children And Recovery Guidelines, Wilailak Langka, Phornchulee Lungka, Narisara Peungposop, Suppawan Satjapiboon
A Study Of The Impact Of Covid-19 On Developmental Decline And Learning Loss In Young Children And Recovery Guidelines, Wilailak Langka, Phornchulee Lungka, Narisara Peungposop, Suppawan Satjapiboon
Journal of Education Studies
The COVID-19 pandemic significantly affected the educational system, particularly in young children education. There are guidelines for providing young children education during the COVID-19 pandemic, however, they are still broad and unclear in practice. This research aims to 1) study the impacts of the COVID-19 situation on early childhood children's developmental and learning regression, 2) analyze causal factors that influence teachers’ readiness to organize learning experiences, and 3) examine guidelines to recover the development of early childhood children. Qualitative data were collected via interviews with 50 participants, consisting of administrators and preschool teachers, while quantitative data were gathered using a …
Strategies For Rebranding In The New Era Of Institutes Under The Office Of The Vocational Education Commission, Napaporn Taraartorn, Sakdinaporn Nuntee, Suchat Bangwiset
Strategies For Rebranding In The New Era Of Institutes Under The Office Of The Vocational Education Commission, Napaporn Taraartorn, Sakdinaporn Nuntee, Suchat Bangwiset
Journal of Education Studies
The objectives of this research were to: 1) study the components of rebranding in the new era of institutes under the Office of the Vocational Education Commission; 2) study the current, desirable conditions and needs of rebranding; and 3) create and develop strategies for rebranding. The research procedures were divided into three phases. Phase 1 involved determining the requisite components by examining documents and interviewing nine experts. Phase 2 involved studying the current, desirable conditions and needs of rebranding; the sample included 390 administrators and teachers. Phase 3 involved creating and developing strategies through a focus group discussion with nine …
Problems And Anxiety Management Of Piano Performance Contestants, Apichai Limtaveekiettikul, Narongchai Pidokrajt
Problems And Anxiety Management Of Piano Performance Contestants, Apichai Limtaveekiettikul, Narongchai Pidokrajt
Journal of Education Studies
Self-regulated anxiety among piano performance contestants is of utmost importance, especially for amateur pianists who lack experiences but still have to endure both internal and external pressure. Eliminating the underlying causes of issues that affect physical health, professional achievements, and lifestyles is crucial. Therefore, learning how to manage anxiety effectively is crucial. This article aims to offer self-management strategies for coping with anxiety during piano performances, particularly for new competitors or those who struggle with anxiety during the show. 1) creating imaginary situations in their minds that could serve as a bridge to reality 2) Planning and preparing in a …
Design And Exploration Of Virtual Multi-Scene Classroom Based On Xr Technology, He Shuang
Design And Exploration Of Virtual Multi-Scene Classroom Based On Xr Technology, He Shuang
Journal of Education Studies
With the advent of the global post-epidemic era, the online and offline hybrid teaching mode and virtual learning environment will become the development trend of curriculum teaching and future teaching space. This virtual reality technology has many application cases in the design and business fields, which shows that the multi-scene application based on XR virtual technology is relatively mature and feasible. This study designs experiments for the on-spot teaching space that integrates virtual and reality. The author conducts multi-scene design simulation through the 3D multi-scene software, with the construction of the physical environment, and the recording and tracking of offline …
Effects Of Organizing Mathematics Learning Activity Using Ill-Structured Problem Solving Process And Scaffolding Strategy On Mathematical Reasoning Ability And Attitude Towards Mathematics Of Ninth Grade Students, Apisara Chanhom, Jongkol Thamsuan
Effects Of Organizing Mathematics Learning Activity Using Ill-Structured Problem Solving Process And Scaffolding Strategy On Mathematical Reasoning Ability And Attitude Towards Mathematics Of Ninth Grade Students, Apisara Chanhom, Jongkol Thamsuan
Journal of Education Studies
The purposes of this research were 1) to compare the mathematical reasoning ability of students before and after engaging in organized mathematics learning activities using an ill-structured problem-solving process combined with scaffolding, and 2) to compare the attitudes towards mathematics of students before and after participating in organized mathematics learning activities using an ill-structured problem solving process combined with scaffolding. The sample group consisted of 30 ninth grade students under the Secondary Educational Service Area Office Bangkok 2, selected through purposive sampling. The tools used for the experiment included mathematics lesson plans using the ill-structured problem-solving process combined with scaffolding. …
The Percentage Of Sacroiliac Fusions Done In The U.S. By Non-Surgical Specialties Has Increased, Mathew Cyriac, Bela P. Delvadia, Julianna E. Winter, Jacob S. Budin, Olivia C. Lee, William F. Sherman
The Percentage Of Sacroiliac Fusions Done In The U.S. By Non-Surgical Specialties Has Increased, Mathew Cyriac, Bela P. Delvadia, Julianna E. Winter, Jacob S. Budin, Olivia C. Lee, William F. Sherman
School of Medicine Faculty Publications
BACKGROUND: Surgical fusion of the sacroiliac (SI) joint is often performed to manage chronic lower back or buttock pain. When Current Procedural Terminology (CPT) codes were introduced, SI joint fusion procedures were done primarily by orthopaedic surgeons and neurosurgeons. The purpose of this study was to examine the utilization of SI joint fusion CPT codes by physician specialty over time. METHODS: A retrospective cohort study was conducted using the PearlDiver database. The database was queried using CPT codes to identify patients who underwent SI joint fusion via percutaneous, open, or trauma codes. Specialties queried included surgical specialties (orthopaedic surgery and …
Irregular Assessment Times In Pragmatic Randomized Clinical Trials, Andrea Apter, Frances K Barg, Sanjib Basu, Alex Federman, Winifred J Hamilton, Jerry A Krishnan, Tianjing Li, Russell Localio, Christine Pindle, Daniel O Scharfstein, Justin D Smith, Kaharu Sumino
Irregular Assessment Times In Pragmatic Randomized Clinical Trials, Andrea Apter, Frances K Barg, Sanjib Basu, Alex Federman, Winifred J Hamilton, Jerry A Krishnan, Tianjing Li, Russell Localio, Christine Pindle, Daniel O Scharfstein, Justin D Smith, Kaharu Sumino
Faculty, Staff and Students Publications
Deviation from protocolized assessment times is commonplace in pragmatic randomized clinical trials. Working with a stakeholder advisory board for a Patient-Centered Outcomes Research Institute®-funded project on statistical methods for handling potential biases introduced by irregular assessment times, we identified reasons for off-schedule or missed assessments. We used the Consolidated Framework for Implementation Research 2.0 to organize our findings. We conjectured that timely completion of outcome assessments is a function of multiple determinants, only some related to participants' health status. We identified potential determinants that can be modified during the protocol design stage and can be reassessed and mitigated during trial …
Testing The Bullet Dwarf Collision Scenario In The Ngc 1052 Group Through Morphologies And Stellar Populations, Yimeng Tang, Aaron J. Romanowsky, Pieter G. Van Dokkum, T. H. Jarrett, Kevin A. Bundy, Maria Luisa Buzzo, Shany Danieli, Jonah S. Gannon, Michael A. Keim, Seppo Laine, Zili Shen
Testing The Bullet Dwarf Collision Scenario In The Ngc 1052 Group Through Morphologies And Stellar Populations, Yimeng Tang, Aaron J. Romanowsky, Pieter G. Van Dokkum, T. H. Jarrett, Kevin A. Bundy, Maria Luisa Buzzo, Shany Danieli, Jonah S. Gannon, Michael A. Keim, Seppo Laine, Zili Shen
Faculty Research, Scholarly, and Creative Activity
NGC 1052-DF2 and -DF4 are two ultradiffuse galaxies that have been reported as deficient in dark matter and associated with the same galaxy group. Recent findings suggest that DF2 and DF4 are part of a large linear substructure of dwarf galaxies that could have been formed from a high-velocity head-on encounter of two gas-rich galaxies, known as a “bullet dwarf” collision. Based on new observations from the Hubble Space Telescope, combined with existing imaging from the u band to mid-infrared, we test the bullet dwarf scenario by studying the morphologies and stellar populations of the trail dwarfs. We find no …
Evolving Uk Biology Education, Helen R. Watson
Evolving Uk Biology Education, Helen R. Watson
Peninsula Medical School
School science curriculum reform is underway in the UK. Whilst each of the four devolved nations is at a different stage in this process, it is clear we are entering an era of opportunity for positive change, where curricula can be updated to reflect our current understanding of science and to better prepare learners for further study, work, and modern life more broadly.
Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – November 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis
Re: Butte Mine Flooding Operable Unit Berkeley Pit And Discharge Pilot Project – November 2024 Monthly Discharge Monitoring Report, Mark Thompson, Dave Griffis
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Re: Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Unreclaimed Sites And Insufficiently Reclaimed Areas – Racetrack Borrow Material Usage (Dated December 19, 2024), Molly Roby
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
A Confidence-Based Knowledge Integration Framework For Cross-Domain Table Question Answering, Yuankai Fan, Tonghui Ren, Can Huang, Beini Zheng, Yinan Jing, Zhenying He, Jinbao Li, Jianxin Li
A Confidence-Based Knowledge Integration Framework For Cross-Domain Table Question Answering, Yuankai Fan, Tonghui Ren, Can Huang, Beini Zheng, Yinan Jing, Zhenying He, Jinbao Li, Jianxin Li
Research outputs 2022 to 2026
Recent advancements in TableQA leverage sequence-to-sequence (Seq2seq) deep learning models to accurately respond to natural language queries. These models achieve this by converting the queries into SQL queries, using information drawn from one or more tables. However, Seq2seq models often produce uncertain (low-confidence) predictions when distributing probability mass across multiple outputs during a decoding step, frequently yielding translation errors. To tackle this problem, we present CKIF, a confidence-based knowledge integration framework that uses a two-stage deep-learning-based ranking technique to mitigate the low-confidence problem commonly associated with Seq2seq models for TableQA. The core idea of CKIF is to introduce a flexible …
The Cumulative Effect Of Ellagic Acid And Carnosic Acid Attenuates Oxidative Events During Diabetic Wound Healing: In Different Applications And On Different Days, Eli̇f Naz Gürsoy, Kanuni̇ Barbaros Balabanli, Fatma Nur Tuğcu Demi̇röz, Şule Coşkun Cevher
The Cumulative Effect Of Ellagic Acid And Carnosic Acid Attenuates Oxidative Events During Diabetic Wound Healing: In Different Applications And On Different Days, Eli̇f Naz Gürsoy, Kanuni̇ Barbaros Balabanli, Fatma Nur Tuğcu Demi̇röz, Şule Coşkun Cevher
Turkish Journal of Biology
Background/aim: The hyperglycemic environment in diabetes disrupts normal wound-healing processes, leading to chronic wounds. This study investigated whether the combination of the phenolic compounds Ellagic acid and Carnosic acid shows synergistic effects on diabetic wound healing and oxidative parameters in diabetic rats.Materials and methods: In this study, diabetic rats were divided into control, untreated, Carbopol 974P treated, topical treatment, and oral gavage treatment. Ellagic acid and Carnosic acid combination were applied topically and oral gavage to the full-thickness excisional wounds of all animals except the control group. We investigated oxidative events by malondialdehyde, glutathione, nitric oxide, protein carbonyl, collagen spectrophotometrically, …
Cannabinoid Receptor Ligands Modulate Fibrosis And Inflammation In Idiopathicpulmonary Fibrosis: A Preliminary Study, Sevi̇l Köse, Seli̇n Önen, Merve Gi̇zer, Esi̇n Boduroğlu, Uğur Gönüllü, Petek Korkusuz
Cannabinoid Receptor Ligands Modulate Fibrosis And Inflammation In Idiopathicpulmonary Fibrosis: A Preliminary Study, Sevi̇l Köse, Seli̇n Önen, Merve Gi̇zer, Esi̇n Boduroğlu, Uğur Gönüllü, Petek Korkusuz
Turkish Journal of Biology
Background/aim: There is no specific pharmacological treatment regimen for idiopathic pulmonary fibrosis (IPF). Therefore, new anti-inflammatory therapeutic strategies are needed. Cannabinoids (CBs) that are known for their inflammation-modulating and anti-fibrotic effects may be potential medication candidates for the treatment of IPF. Our aim is to evaluate the inflammation-modulating and anti-fibrotic effects of CB receptor (CBR) agonists and antagonists in lipopolysaccharide (LPS) stimulated human lung healthy fibroblast, epithelial cells, IPF fibroblast cells and monocytes.Materials and methods: We detected CBRs in the human lung healthy (LL24) and IPF fibroblast cells (LL29), epithelial cells (A549) and monocytes (THP-1) by flow cytometry (FC). We …
Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir
Development Of An Immunodiagnostic Assay For The Detection Of Sugarcane Mosaic Virus, Hafiz Muhammad Khalid, Najam Us Sahar Sadaf Zaidi, Naeem Rashid, Muhammad Tahir
Turkish Journal of Biology
Background/Aim: Sugarcane mosaic virus (SCMV; genus Potyvirus and family Potyviridae), poses a significant threat to global sugarcane cultivars, including those in Pakistan. The aim of this study was to develop a rapid and effective diagnostic tool for detection of SCMV, enabling timely implementation of control measures to mitigate potential yield losses.Materials and Methods: The study focused on the in silico analysis; physicochemical properties, immunogenicity and subcellular localization of the SCMV coat protein (CP). The SCMV coat protein (CP) gene was synthesized, cloned and expressed in Escherichia coli. The recombinant fusion coat protein (rFCP-SCMV) was purified and used to generate polyclonal …
Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n
Combinational Therapy Of All-Trans Retinoic Acid (Atra) And Sphingomyelin Induces Apoptosis And Cell Cycle Arrest In B16f10 Melanoma Cancer Cell, Zeynep İşlek Köklü, Eli̇f Li̇dya Şanverdi̇, Başak Karadağ, Mehmet Hi̇kmet Üçişik, Ezgi̇ Taşkan, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Background: Melanoma arises from the uncontrolled multiplication of melanocytes, posing an escalating global health concern. Despite early detection and surgical removal being crucial, metastatic melanoma poses treatment challenges, with limited options like chemotherapy and immunotherapy. All-trans retinoic acid (ATRA), a natural metabolite of vitamin A, has shown promise in melanoma treatment by inducing differentiation, apoptosis, growth arrest, and immune modulation. However, ATRA treatment alone can lead to resistance and relapse. Sphingomyelin (SM) also plays a role in inhibiting melanoma progression by apoptotic cell death.Objective: This study investigated combinational anticancer effects of ATRA and SM on in vitro B16F10 melanoma cells.Method: …
Rna-Dependent Rna Polymerase Of Predominant Human Norovirus Forms Liquid-Liquid Phase Condensates As Viral Replication Factories, Soni Kaundal, Ramakrishnan Anish, B Vijayalakshmi Ayyar, Sreejesh Shanker, Gundeep Kaur, Sue E Crawford, Jeroen Pollet, Fabio Stossi, Mary K Estes, B V Venkataram Prasad
Rna-Dependent Rna Polymerase Of Predominant Human Norovirus Forms Liquid-Liquid Phase Condensates As Viral Replication Factories, Soni Kaundal, Ramakrishnan Anish, B Vijayalakshmi Ayyar, Sreejesh Shanker, Gundeep Kaur, Sue E Crawford, Jeroen Pollet, Fabio Stossi, Mary K Estes, B V Venkataram Prasad
Faculty, Staff and Students Publications
Many viral proteins form biomolecular condensates via liquid-liquid phase separation (LLPS) to support viral replication and evade host antiviral responses, and thus, they are potential targets for designing antivirals. In the case of nonenveloped positive-sense RNA viruses, forming such condensates for viral replication is unclear and less understood. Human noroviruses (HuNoVs) are positive-sense RNA viruses that cause epidemic and sporadic gastroenteritis worldwide. Here, we show that the RNA-dependent RNA polymerase (RdRp) of pandemic GII.4 HuNoV forms distinct condensates that exhibit all the signature properties of LLPS with sustained polymerase activity and the capability of recruiting components essential for viral replication. …
Fhsu Rodeo Champions Show Competitive Edge In A Thriving Program, December 20, 2024, Tisa Mason Ed.D.
Fhsu Rodeo Champions Show Competitive Edge In A Thriving Program, December 20, 2024, Tisa Mason Ed.D.
Heart of a Tiger Columns
No abstract provided.
Bile Acids In Inflammatory Bowel Disease: From Pathophysiology To Treatment, Samantha H Bai, Arun Chandnani, Siyan Cao
Bile Acids In Inflammatory Bowel Disease: From Pathophysiology To Treatment, Samantha H Bai, Arun Chandnani, Siyan Cao
2020-Current year OA Pubs
Inflammatory bowel disease (IBD) is a chronic condition that affects about 7 million people worldwide, and new therapies are needed. Understanding the complex roles that bile acids (BAs) play in IBD may lead to the development of novel IBD treatments independent of direct immunosuppression. This review discusses the latest discoveries in the roles BAs play in IBD pathogenesis and explores how these discoveries offer promising new therapeutic targets to treat IBD and improve patient outcomes. Several therapies discussed include specific BA receptor (BAR) agonists, dietary therapies, supplements, probiotics, and mesenchymal stem cell therapies that have all been shown to decrease …
Retrospective Derivation Of A Causal Pathway For Diabetic Ketoacidosis In Adult Patients With Type 2 Diabetes Mellitus, Jeffrey A Kline, Nicholas A Wesner, Amina T Sharif, Richard T Griffey, Phillip D Levy, Robert D Welch, George Grunberger
Retrospective Derivation Of A Causal Pathway For Diabetic Ketoacidosis In Adult Patients With Type 2 Diabetes Mellitus, Jeffrey A Kline, Nicholas A Wesner, Amina T Sharif, Richard T Griffey, Phillip D Levy, Robert D Welch, George Grunberger
2020-Current year OA Pubs
BACKGROUND: Type 2 ketone-prone diabetes mellitus (T2KPDM) is thought to occur in men of African descent, with obesity who experienced prolonged hyperglycemia; the role of medication non-adherence as a contributing cause remains unstudied.
RESEARCH DESIGN AND METHODS: This was a retrospective study of unique adults (>18 years) who sought emergency care one of four hospitals in the greater Detroit area. Patients were identified on the basis of a laboratory order for a ß-hydroxybutyrate concentration. Two research coordinators abstracted 119 data fields. Patients were divided into four phenotypes: (1) no prior DM, (2) type 2 DM without prior ketosis, (3) …
Ifrd1 Is Required For Maintenance Of Bladder Epithelial Homeostasis, Bisiayo E Fashemi, Amala K Rougeau, Arnold M Salazar, Steven J Bark, Rayvanth Chappidi, Jeffrey W Brown, Charles J Cho, Jason C Mills, Indira U Mysorekar
Ifrd1 Is Required For Maintenance Of Bladder Epithelial Homeostasis, Bisiayo E Fashemi, Amala K Rougeau, Arnold M Salazar, Steven J Bark, Rayvanth Chappidi, Jeffrey W Brown, Charles J Cho, Jason C Mills, Indira U Mysorekar
2020-Current year OA Pubs
The maintenance of homeostasis and rapid regeneration of the urothelium following stress are critical for bladder function. Here, we identify a key role for IFRD1 in maintaining urothelial homeostasis in a mouse model. We demonstrate that the murine bladder expresses IFRD1 at homeostasis, particularly in the urothelium, and its loss alters the global transcriptome with significant accumulation of endolysosomes and dysregulated uroplakin expression pattern. We show that IFRD1 interacts with mRNA-translation-regulating factors in human urothelial cells. Loss of