Digital Commons Network^™

Targeting Of Oncogenic Aaa-Atpase Trip13 Reduces Progression Of Pancreatic Ductal Adenocarcinoma, Farrukh Afaq, Sumit Agarwal, Prachi Bajpai, Sameer Al Diffalha, Hyung-Gyoon Kim, Shajan Peter, Moh'd Khushman, Subhash Chauhan, Priyabrata Mukherjee, Sooryanarayana Varambally, Upender Manne

School of Medicine Publications

Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP13 knockdown or treatment of PDAC cells with DCZ0415 reduced proliferation and colony formation, and induced G2/M cell cycle arrest and apoptosis. Additionally, TRIP13 knockdown …

P513: Project Give: Expanding Genetic Testing To Underserved Areas In The Rio Grande Valley Using An Ehr-Agnostic Tele-Engagement Platform, Blake Vuocolo, Roberta Sierra, Kent Carter, Keila Rodriguez, Lori Berry, Ana Hernandez, Humberto Hidalgo, Alberto Allegre, Sandy Magallan, Sarah Rodriguez

School of Medicine Publications

Introduction

Providing an accurate genetic diagnosis to children in a timely manner is crucial for providing appropriate medical interventions, counseling families about recurrence risks, and addressing the psychosocial and financial challenges that are known to be associated with diagnostic odysseys. Unfortunately, underserved and under resourced areas across the nation have poor access to genetic testing. There is a significant disparity in access to genomic healthcare in the Rio Grande Valley (RGV) along the Texas-Mexico border, which has a population of about 1.4 million residents and no local full-time genetics provider. Over 94% of the population in the RGV is Hispanic, …

A Neural Mechanism For Conserved Value Computations Integrating Information And Rewards, Ethan S Bromberg-Martin, Yang-Yang Feng, Takaya Ogasawara, J Kael White, Kaining Zhang, Ilya E Monosov

2020-Current year OA Pubs

Behavioral and economic theory dictate that we decide between options based on their values. However, humans and animals eagerly seek information about uncertain future rewards, even when this does not provide any objective value. This implies that decisions are made by endowing information with subjective value and integrating it with the value of extrinsic rewards, but the mechanism is unknown. Here, we show that human and monkey value judgements obey strikingly conserved computational principles during multi-attribute decisions trading off information and extrinsic reward. We then identify a neural substrate in a highly conserved ancient structure, the lateral habenula (LHb). LHb …

Extending Natural Mates In Euclidean 3-Space And Applications To Bertrand Pairs, Yun Myung Oh, Alexander Navarro

Faculty Publications

In Euclidean 3-space, a family of curves, the co-successor, is motivated and then introduced in relation to the natural mate. A complete characterization of co-successors is proved, followed by an application of the co-successor towards describing Bertrand curves and their mates.

Who Has The Most Influence On Your Spirituality?, S. Joseph Kidder, Natalie M. Darisme

Faculty Publications

No abstract provided.

The Mediating Effect Of Financial Literacy On Blockchain Technology Application And Financial Risk: Insight From Ghanaian Professionals Toward Policy Recommendations, Maxwell Okpoti Mensah, Williams Kwasi Peprah [email protected]

Faculty Publications

This study explores the mediating effect of financial literacy on the relationship between blockchain technology application and financial risk among financial institution professionals in Ghana. Utilizing a correlational research design, data were collected from a sample of 336 professionals through a self-constructed Likert-scale questionnaire. The analysis was conducted using path analysis and mediation techniques. The findings reveal that financial literacy had a significant partial mediating effect between blockchain technology application and financial risk, accounting for 26.0% of the total effect. The direct negative effect of blockchain technology applications on financial risk also remained significant, highlighting the independent contribution of blockchain …

Inactive Metallopeptidase Homologs: The Secret Lives Of Pseudopeptidases, Peter Lyons

Faculty Publications

Inactive enzyme homologs, or pseudoenzymes, are proteins, found within most enzyme families, that are incapable of performing catalysis. Rather than catalysis, they are involved in protein-protein interactions, sometimes regulating the activity of their active enzyme cousins, or scaffolding protein complexes. Pseudoenzymes found within metallopeptidase families likewise perform these functions. Pseudoenzymes within the M14 carboxypeptidase family interact with collagens within the extracellular space, while pseudopeptidase members of the M12 "a disintegrin and metalloprotease" (ADAM) family either discard their pseudopeptidase domains as unnecessary for their roles in sperm maturation or utilize surface loops to enable assembly of key complexes at neuronal synapses. …

Review Of "Roosevelt Institute.", Katharine M. Van Arsdale

Faculty Publications

No abstract provided.

Review Of The Myth Of Middle East Exceptionalism: Unfinished Social Movements Movements, Shahrzad Khosrowpour

Library Articles and Research

A review of The Myth of Middle East exceptionalism: Unfinished Social Movements by Mojtaba Mahdavi.

Review Of How Ai Works: From Sorcery To Science, By Ronald T. Kneusel, Taylor J. Greene

Library Articles and Research

A review of How AI Works: From Sorcery to Science, by Ronald T. Kneusel.

Review Of Who Wrote This?: How Ai And The Lure Of Efficiency Threaten Human Writing, By Naomi S. Baron, Taylor J. Greene

Library Articles and Research

A review of Who Wrote This?: How AI and the Lure of Efficiency Threaten Human Writing, by Naomi S. Baron.

Non-Human Stakeholders: Testing The Boundaries Of Stakeholder Theory, Justin Blount, Michael Conklin

Oklahoma Law Review

No abstract provided.

Market Failure And Censorship In The Marketplace Of Ideas, John P. Anderson, Jeremy Kidd

Oklahoma Law Review

No abstract provided.

Tesla, Let Me Fix My Car: The Right To Repair And The Need For A Balance Between Public And Private Enforcement, Emanuele S. Putrino

Oklahoma Law Review

No abstract provided.

Prioritizing Oklahoma Mothers: Recommending Rehabilitation And Recovery Rather Than Punishment For Pregnancy, Alex B. Cox

Oklahoma Law Review

No abstract provided.

Cyberflashing: Exposing Oklahoma’S Legal Loophole, Sara Wray

Oklahoma Law Review

No abstract provided.

Women In Religious Leadership Roles, Amanda Wadkins

Graduate Theses/Dissertations

The experiences of women in leadership have been well studied in academia, but there remains a gap in the literature regarding and understanding of the experiences of women who are in religious leadership roles. I examined what challenges these women experience in their roles, and how they make sense of those challenges, using the constant comparative method of data analysis to analyze interviews with 12 women who have leadership roles within their protestant church or nonprofit organization. The results indicate that these individuals experience challenges that are consistent with past research on women in leadership. However, the results also illustrate …

Brighter Days, Erich J. Eastman

Graduate Theses/Dissertations

Brighter Days is a musical composition for choir, solo voice, and guitar, depicting the stages of an emotional journey through five separate movements. Each movement represents a different set of feelings, exploring themes of frustration, perseverance, hope, elation, and other sentiments. The movements are interconnected, employing key relationships and cross-references throughout the work. Musical styles vary, and genres are blended to create tonal landscapes that are both unique and accessible. Brighter Days is an expressive new work about finding light in darkness and coming to terms with oneself.

Word Reimagined: Analyzing Fanfiction's Transformative Force And Relationship With The Young Adult Literary Landscape, Megan Louise Reaves

Graduate Theses/Dissertations

In exploring the reciprocal relationship between fanfiction and Young Adult (YA) literature, this thesis investigates how these two forms of storytelling, influenced by authors such as Marissa Meyer and Rainbow Rowell, have profoundly impacted the literary landscape. Marissa Meyer's The Lunar Chronicles series and Rainbow Rowell's novels Fangirl and Carry On serve as prime examples of this dynamic interaction. Drawing from the rich traditions of oral storytelling and folklore, fanfiction and YA literature have undergone significant development and popularity, particularly in the twenty-first century, thanks to technological advancements and the rise of online communities. This thesis contends that despite their …

Body. Freedom. Choice: Creating Artwork In Post-Roe America, Erin Sedra

Graduate Theses/Dissertations

I knew from a young age that I never wanted children. Whenever I expressed my disinterest in motherhood, I was often met with bewilderment, disapproval, and hostility. The church I was raised in taught me that my value and worth as a woman directly correlated with the power of my birthing hips. This fundamentalist upbringing has significantly shaped my relationship with my femininity, my body, and my artwork. When I feel powerless, turning to my art gives me a sense of control and self-expression. This body of work began as a reaction to the overturning of Roe v. Wade and …

Recollection, Shelby Ann Theis-Lukenbill

Graduate Theses/Dissertations

My work is inspired by life's transient nature and objects' enduring capacity to house memories. The delicate sculptures I create combine second-hand objects with paper to capture the essence of moments and possessions that define personal histories. The objects I use represent more than their form or chemistry; they are imbued with fragments of history and memory that I am driven to preserve. In this work, the sentimental nature and purpose of my belongings hold an equal or greater value than the physical nature and purpose of those belongings. I illuminate an object’s sentimentality by combining its form with painted …

Exploring Band Students' Motivations Regarding Instrument Selection, Aaron S. Morley

Graduate Theses/Dissertations

When choosing a beginning band instrument, students are faced with a choice that may be influenced by a variety of factors. These factors also interest band directors, who want students to choose an instrument that will be a good fit for their strengths while also being engaging to them. To assist directors in guiding students through instrument selection it is helpful to know what factors could influence students when they are choosing an instrument. To identify the factors that students report as impactful, beginning band students in five northwest Missouri school districts were surveyed about the influence of selected factors. …

Empowered Womanhood In Rokeya Sakhawat Hossain’S “Sultana’S Dream” And Greta Gerwig’S Barbie: Keys To The Ideal World, Tasnuva Tabassum

Graduate Theses/Dissertations

Rokeya Sakhawat Hossain’s “Sultana’s Dream” (1905) and Greta Gerwig’s Barbie (2023) present feminist utopias separated by more than a century. Despite the temporal gap, both works introduce worlds where traditional gender roles are reversed. This thesis explores Hossain’s and Gerwig’s suggestions to create ideal worlds through empowerment of women. Considering evolution of feminist utopian thought from the beginning of the twentieth century to the beginning of the twenty-first, and the differences in feminisms from East to West, this thesis analyzes the narrative structures, thematic elements, and cultural contexts of these works. Despite differences, both authors seek not just female but …

Outside Inside: Poems, Emma Jane Sullivan

Graduate Theses/Dissertations

This creative thesis includes thirty-four poems and thirteen illustrations that investigate the topic of self-exploration, creative freedom, and liberatory pleasure. My poems are souvenirs from a failed ethical standard, a trove of misogynic micro-aggressions, a spotlight on the backward- ness of gender norms, and a surprisingly strong thread that links women to the planet and to shared language, a thread humankind continuously tries to cut. The methods of research were largely a self- study and one that required consistent reflection. The results were a collection of writings that had to be revised and edited with the guidance of my thesis …

Million-Year Melt-Presence In Mogollon-Datil Volcanic Field Rhyolites: Constraining The Histories Of The Bursum Caldera Resurgent Domes, Ethan Wagner

Graduate Theses/Dissertations

The Mogollon-Datil volcanic field which is located in southwestern New Mexico, is the result of punctuated volcanism and the transition between arc and rift magmatism. The resurgent domes within the 28 Ma Bursum caldera records the transition from rhyolitic to basaltic andesite volcanism that occurred between 27-26 Ma. Using a combination of new zircon U-Pb ages using chemical abrasion isotope dilution thermal ionization mass spectrometry (CA-ID-TIMS) with zircon U-Pb geochronology and trace element contents by laser ablation inductively coupled plasma mass spectrometry (LA-ICPMS) and whole rock and mineral trace element contents and isotope geochemistry this study investigates the temporal and …

Sixth Grade Music Ensemble Exploratories: Promoting Accessibility In Music Education, Michaela Marie Chybowski

Graduate Theses/Dissertations

School music ensemble participation has many benefits for students, including social well-being and improving academic performance; however, a variety of barriers, such as fear or lack of interest prevent many students from participating. To improve recruitment in music ensemble classes, Pittsburg Community Middle School created an exploratory class schedule that commenced with the 2022-2023 school year during which almost all sixth-grade students enrolled in three-week rotations of band, choir, and orchestra with the option to choose one option for the rest of the school year. This action research examined this new curriculum and the self-motivations of students who enrolled in …

Business Communications, Steelman Library, Beth Leslie Dr.

Syllabus Repository

No abstract provided.

Principles Of Financial Accounting, Steelman Library, Natasha Ware

Syllabus Repository

No abstract provided.

Principles Of Management, Steelman Library, Beth Leslie Dr.

Syllabus Repository

No abstract provided.

Business Policies, Steelman Library

Syllabus Repository

No abstract provided.