Digital Commons Network^™

Loss Of The Scavenger Receptor Marco Results In Uncontrolled Vomocytosis Of Fungi From Macrophages, Chinaemerem U. Onyishi, Yusun Jeon, Gyorgy Fejer, Subhankar Mukhopadhyay, Siamon Gordon, Robin C. May

School of Biomedical Sciences

Vomocytosis, also known as nonlytic exocytosis, is a process whereby fully phagocytosed microbes are expelled from phagocytes without discernible damage to either the phagocyte or microbe. Although this phenomenon was first described in the opportunistic fungal pathogen Cryptococcus neoformans in 2006, to date, mechanistic studies have been hampered by an inability to reliably stimulate or inhibit vomocytosis. Here we present the fortuitous discovery that macrophages lacking the scavenger receptor MAcrophage Receptor with COllagenous domain (MARCO), exhibit near-total vomocytosis of internalised cryptococci within a few hours of infection. Marco^−/− macrophages also showed elevated vomocytosis of a yeast-locked C. albicans strain, …

Co-Producing Ethics Guidelines Together With People With Learning Disabilities, Mary Bottomley, Jodie Bradley, Lisa Clark, Bryan Collis, Bojana Daw Srdanovic, Victoria Farnsworth, Annie Ferguson, Dan Goodley, Andrew Fox, Nikita K. Hayden, Charlotte Lawthom, Rebecca Lawthom, Claudia Magwood, Robert Mclean, Ian Middleton, Alison Owen, Matty Prothero, Simon Rice, Simon Richards, Katherine Runswick-Cole, Kelly Scargill, Rohit Shankar, Toni Ann Wood

Peninsula Medical School

Background: We are a research team of clinical, academic and advocacy-based researchers with and without learning disabilities, working on the Humanising Healthcare (for people with learning disabilities) project. The project is dedicated to finding and sharing healthcare practices that enhance the lives of people with learning disabilities. As part of our ethics applications to access National Health Service study sites for fieldwork, we worked together to write guiding principles for co-producing research ethics with researchers with learning disabilities. In this paper, we introduce these Participatory Ethics Good Practice Guidelines and reflect on our collaboration. Methods: We reflect on developing the …

The Cost Of Providing Care By Family And Friends (Informal Care) In The Last Year Of Life: A Population Observational Study, Miriam J. Johnson, David C. Currow, Jade Chynoweth, Helen Weatherly, Gamze Keser, Ann Hutchinson, Annie Jones, Laurie Dunn, Victoria Allgar

Peninsula Medical School

Introduction: Little is known about replacement costs of care provided by informal carers during the last year of life for people dying of cancer and non-cancer diseases. Aim: To estimate informal caregiving costs and explore the relationship with carer and decedent characteristics. Design: National observational study of bereaved carers. Questions included informal end-of-life caregiving into the 2017 Health Survey for England including estimated recalled frequency, duration and intensity of care provision. We estimated replacement costs for a decedent’s last year of life valuing time at the price of a substitutable activity. Spearman rank correlations and multivariable linear regression were used …

Improved Structure And Function In Early-Detected Second-Eye Neovascular Age-Related Macular Degeneration: Fasbat/Early Detection Of Neovascular Age-Related Macular Degeneration Report 1, Fasbat Study Group, Richard P Gale, Archana Airody, Sobha Sivaprasad, Rachel L W Hanson, Victoria Allgar, Martin Mckibbin, Antony B Morland, Tunde Peto, Mia Porteous, Usha Chakravarthy

Peninsula Medical School

PURPOSE: Visual acuity (VA) and structural biomarker assessment before and 24-months after early detection and routine treatment of second-eye involvement with neovascular age-related macular degeneration (nAMD) and additional comparison with the first eye affected.

DESIGN: Prospective, 22-center observational study of participants with unilateral nAMD in the Early Detection of Neovascular AMD (EDNA) study, coenrolled into the Observing Fibrosis, Macular Atrophy and Subretinal Highly Reflective Material, Before and After Intervention with anti-VEGF Treatment (FASBAT) study for an additional 2-year follow-up.

PARTICIPANTS: Older adults (> 50 years) with new onset nAMD in the first eye.

METHODS: Assessment of both eyes with OCT, …

Transformation Of Autophagic Sqstm1 Droplets To Sqstm1-Dependent P-Bodies, Evelina Valionyte, Elizabeth R. Barrow, Chris R. Baxter, Sharon Herath, Shouqing Luo

Peninsula Medical School

SQSTM1/p62 droplets play crucial roles in droplets-based macroautophagy/autophagy including selective autophagy and bulk autophagy. We observed that under several stress milieus, SQSTM1 droplets entirely colocalize with P-body markers, and these stress-induced SQSTM1 droplets contain mRNAs. We thus determined that under certain stress conditions, autophagic SQSTM1 droplets are converted to a type of enlarged P-bodies, designated SQSTM1/p62-dependent P-bodies (pd-PBs). Stress-enhanced SQSTM1 droplet formation drives the nucleation of pd-PBs through the interaction between SQSTM1 and the RNA-binding protein DDX6. Furthermore, pd-PBs sequester PYCARD, facilitating the assembly of NLRP3 inflammasomes, and in turn induce inflammation-related cytotoxicity. Our study suggests that under stress settings, …

Effect Of Skin Tone On The Accuracy Of The Estimation Of Arterial Oxygen Saturation By Pulse Oximetry: A Systematic Review, Daniel Martin, Chris Johns, Lexy Sorrell, Eugene Healy, Mandeep Phull, Segun Olusanya, Mark Peters, Jeremy Fabes

Peninsula Medical School

Background: Pulse oximetry-derived oxygen saturation (SpO₂) is an estimate of true arterial oxygen saturation (SaO₂). The aim of this review was to evaluate available evidence determining the effect of skin tone on the ability of pulse oximeters to accurately estimate SaO₂. Methods: Published literature was screened to identify clinical and non-clinical studies enrolling adults and children when SpO₂ was compared with a paired co-oximetry SaO₂ value. We searched literature databases from their inception to March 20, 2023. Risk of bias (RoB) was assessed using the QUADAS-2 tool. Certainty of assessment was evaluated …

Perioperative Oxygenation—What's The Stress?, Joseph Larvin, Mark Edwards, Daniel S. Martin, Martin Feelisch, Michael P.W. Grocott, Andrew F. Cumpstey

Peninsula Medical School

Oxygen is the most used drug in anaesthesia. Despite such widespread use, optimal perioperative oxygen administration remains highly controversial because of concerns about the competing harms of both hyperoxia and hypoxia. Notwithstanding a Cochrane review concluding that routinely administering a fractional inspired oxygen concentration (FiO₂) >0.6 intraoperatively might increase postoperative morbidity and mortality, the World Health Organization (WHO) currently recommends all anaesthetised patients receive 0.8 FiO₂ during and immediately after surgery to reduce surgical site infections. Results from the largest trial available at the time of these two reviews (suggesting long-term survival may be worse with high …

Training Needs For Staff Providing Remote Services In General Practice: A Mixed-Methods Study, Trisha Greenhalgh, Rebecca Payne, Nina Hemmings, Helen Leach, Isabel Hanson, Anwar Khan, Lisa Miller, Emma Ladds, Aileen Clarke, Sara E. Shaw, Francesca Dakin, Sietse Wieringa, Sarah Rybczynska-Bunt, Stuart D. Faulkner, Richard Byng, Asli Kalin, Lucy Moore, Joseph Wherton, Laiba Husain, Rebecca Rosen

Peninsula Medical School

Background Contemporary general practice includes many kinds of remote encounter. The rise in telephone, video and online modalities for triage and clinical care requires clinicians and support staff to be trained, both individually and as teams, but evidence-based competencies have not previously been produced for general practice. Aim To identify training needs, core competencies, and learning methods for staff providing remote encounters. Design and setting Mixed-methods study in UK general practice. Method Data were collated from longitudinal ethnographic case studies of 12 general practices; a multi-stakeholder workshop; interviews with policymakers, training providers, and trainees; published research; and grey literature (such …

The Mini-Cog: A Community Screening Tool For Dementia In Indonesia, Yuda Turana, Nicolas Farina, Imelda Theresia, Tara Puspitarini Sani, Ika Suswanti, Fasihah Irfani Fitri, Emiliano Albanese, Adelina Comas-Herrera, Martin Knapp, Sube Banerjee

Peninsula Medical School

Background: Early detection of dementia enables more effective planning and can enable access to treatment and support. The Mini-Cog is a widely used screening instrument in Indonesia; however, this instrument has never undergone a translation and cultural adaptation process. Currently, there is no data on how accurate the tool is against diagnostic criteria, particularly in low-education. Methods: Embedded within the community-based dementia prevalence study was the Strengthening Responses to Dementia in Developing Countries (STRiDE) project; older adults (aged ≥ 65 years) were randomly recruited from sites in Jakarta and North Sumatra, Indonesia. All participants were asked to complete the Mini-Cog …

Editorial: Bacteriocins And Other Ribosomally Synthesised And Post-Translationally Modified Peptides (Ripps) As Modulators Of The Microbiome, Harsh Mathur, Des Field, Caitriona Guinane, Maire Begley, Mathew Upton, Hilario C. Mantovani, Paul D. Cotter

School of Biomedical Sciences

No abstract provided.

Quality Assessment Of Esg Reporting Among Listed Maritime Companies: Quality Assessment Of Esg Reporting…: M. Tsatsaronis Et Al., M. Tsatsaronis, T. Syriopoulos, S. Karamperidis, G. Boura, A. Dimopoulos

Plymouth Business School

Regulatory obligations and market trends connected to environmental sustainability issues have lately intensified their effect on the shipping industry. New standards are continuously being established, such as IMO’s 2050 aim of lowering greenhouse gas emissions by 50% compared to 2008 levels. These rules have an impact on capital markets and on investors’ ship financing decisions. The standards now include Environmental, Social, and Governance (ESG) components. These are not only concerned with the environmental impact of shipping, but also with the social and governance dimensions of firms, which are typically associated with maritime transport risks, such as accidents, ship reservations, and …

The Tourism Demarketing Mix: Working To Reduce Revisits To Egyptian Nature Reserves, Ahmed M. Elsetouhi, Mohamed E. Elshourbagi, Ahmed A. Hammad, Alaa A. Elnazer

Plymouth Business School

This study tests the impact of the tourism demarketing mix (product, price, place, promotion) on tourists’ intention to reduce revisits to nature reserves in Egypt. In particular, this work focuses on the moderating role of switching cost. Data were collected from 401 tourists of the Wadi Degla and Petrified Forest nature reserves in Egypt. Path analysis is employed to test the research hypotheses using WarpPLS 6. Findings confirm that the tourism demarketing mix significantly affects tourists’ perception and intention to reduce revisits to the nature reserves. Lower switching cost partially enhanced the relationship between the tourism demarketing mix and tourists’ …

Undergraduate Dental Curricula In Middle Eastern And Arabic-Speaking African Nations − A Cross-Sectional Study, Lovely Muthiah Annamma, Jumma Al Khabuli, Sabrin Ali Azim, Huda Abutayyem, Mohamed Alkhuboli, A. Subaveerapandiyan, Rebecca Glanville, Kamran Ali

Peninsula Dental School

Purpose: To evaluate the design of undergraduate curricula, teaching and learning practices, assessments, admission criteria and quality assurance in dental schools across Middle Eastern and Arab-speaking African nations. Methodology: A cross-sectional survey was sent to 40 dental colleges in the Middle East and African Arabic-speaking countries. A purposefully designed proforma consisting of 21 items divided into five sections based on admission criteria, curriculum delivery, teaching and learning practices, assessment methods, and quality assurance was used for data collection on Google forms. Participation in the survey was voluntary and all participants were consented before data collection. The data was analysed for …

Shipwrecks Act As De Facto Marine Protected Areas In Areas Of Heavy Fishing Pressure, Jenny Hickman, Joe Richards, Adam Rees, Emma V. Sheehan

School of Biological and Marine Sciences

Ubiquitous, industrial use of bottom‐towed fishing gear since the 1800s has altered marine communities and ecosystem services. Outside of legal protection, only areas inaccessible to trawlers are offered any protection. Shipwrecks present hazards to fishing gear and are rarely subject to trawling pressure. As many have been in situ for >100 years, they offer a baseline of ecological potential when trawling pressure is reduced or removed. Five shipwrecks were surveyed off the Berwickshire coast, some within the Static Gear Reserve and others outside. Video transects were collected of shipwrecks, the surrounding 50 m radius and control locations >150 m from …

Double Testing With Lateral Flow Antigen Test Devices For Covid-19: Does A Second Test In Quick Succession Add Value?, Matthias E Futschik, Sarah A Tunkel, Elena Turek, David Chapman, Zareen Thorlu-Bangura, Raghavendran Kulasegaran-Shylini, Edward Blandford, Andrew Dodgson, Paul E Klapper, Malur Sudhanva, Derrick Crook, John Bell, Susan Hopkins, Tim Peto, Tom Fowler

School of Biomedical Sciences

BACKGROUND/OBJECTIVES: We investigated if performing two lateral flow device (LFD) tests, LFD2 immediately after LFD1, could improve diagnostic sensitivity or specificity for detecting severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) antigen.

STUDY DESIGN: Individuals aged ≥16 years attending UK community testing sites (February-May 2021) performed two successive LFD tests and provided a nose-and-throat sample for a polymerase chain reaction (PCR) test. Using the PCR result as the reference diagnosis, we assessed whether improvements could be achieved in sensitivity (by counting a positive result in either LFD as a positive overall test result) or specificity (by using LFD2 as confirmatory test). …

Optimizing Group Work Strategies In Virtual Dissection, Lily Evans, Lauren Singer, Daniel Zahra, Ifeoluwa Agbeja, Siobhan M. Moyes

Peninsula Medical School

Due to its haptic and interactive nature, virtual anatomy provides an opportunity for small-group learning, enabling students to develop their group work skills before they graduate. However, there is currently little practical guidance supported by pedagogic principles detailing how to incorporate it into curricula. Anatomy educators at the University of Plymouth conducted action research aiming to capture students' overall perceptions of the virtual anatomy platform Anatomage. Questioning the benefits and challenges students face while interacting with Anatomage prompted the creation of evidence-based interventions to be later evaluated. Although a plethora of themes were identified, this report specifically examines those relating …

Ship Recycling In Developing Economies Of South Asia: Changing Liability To A Commodity, Bisma Mannan, Md Jahir Rizvi, Yong Ming Dai

School of Engineering, Computing and Mathematics

The end-of-life (EOL) of ships which is neglected and considered a liability by developed economies of the western world. However, it has become a commodity in the developing economies of South Asian countries. Ship recycling activities are considered extremely dangerous by the International Labour Organization (ILO); however, if ship recycling operations are well-managed then they can play a vital role in achieving circular economy and UN sustainable development goals. This study critically examines recent developments in key ship recycling nations, shedding light on both opportunities and challenges faced by this evolving industry. By delving into the socio-economic benefits and presenting …

Collaborative Care Intervention For Individuals With Severe Mental Illness: The Partners2 Programme Including Complex Intervention Development And Cluster Rct, Humera Plappert, Richard Byng, Siobhan Theresa Reilly, Charley Hobson-Merrett, Jon Allard, Elina Baker, Nicky Britten, Melanie Calvert, Michael Clark, Siobhan Creanor, Linda Davies, Rebecca Denyer, Julia Frost, Linda Gask, Bliss Gibbons, John Gibson, Laura Gill, Ruth Gwernan-Jones, Joanne Hosking, Peter Huxley, Alison Jeffery, Benjamin Jones, Tom Keeley, Richard Laugharne, Steven Marwaha, Claire Planner, Tim Rawcliffe, Ameeta Retzer, Debra Richards, Ruth Sayers

Peninsula Medical School

Background and aims: Individuals living with severe mental illness such as schizophrenia and bipolar can have significant emotional, cognitive, physical and social challenges. Most people with severe mental illness in the United Kingdom do not receive specialist mental health care. Collaborative care is a system of support that combines clinical and organisational components to provide integrated and person-centred care. It has not been tested for severe mental illness in the United Kingdom. We aimed to develop and evaluate a primary care-based collaborative care model (PARTNERS) designed to improve quality of life for people with diagnoses of schizophrenia, bipolar or other …

Association Between Glucagon-Like Peptide-1 Receptor Agonists Use And Change In Alcohol Consumption: A Systematic Review, Mohsan Subhani, Ashwin Dhanda, James A. King, Fiona C. Warren, Siobhan Creanor, Melanie J. Davies, Sally Eldeghaidy, Stephen Bawden, Penny A. Gowland, Ramon Bataller, Justin Greenwood, Stephen Kaar, Neeraj Bhala, Guruprasad P. Aithal

Peninsula Medical School

Background: Despite the availability of various pharmacological and behavioural interventions, alcohol-related mortality is rising. This systematic review aimed to critically evaluate the existing literature on the association between glucagon-like peptide-1 receptor agonists use (GLP-1 RAs) and alcohol consumption. Methods: Electronic searches were conducted on Ovid Medline, EMBASE, PsycINFO, clintrials.gov, and ProQuest until the end of March 2024. An updated search was done on 7th of August 2024. The primary outcome was to explore the association between GLP-1 RAs use and change in alcohol consumption. Secondary outcomes included evaluating the impact of GLP-1 RAs on occurrences of alcohol-related events, healthcare utilisation, …

Thermal-Induced Buoyant Water Jet Discharge Under Shallow Coastal Water Conditions, Amir Bordbar, Yong Ming Dai, Simone Michele, Ola Zawalna-Geer, Zhengwei Chen, Salah A. Faroughi, Yeaw Chu Lee

School of Engineering, Computing and Mathematics

A novel discharge dispersion model is developed to simulate the complex three-dimensional flow behaviour of thermal-induced buoyant water jets under current-wave coexisting conditions. The model solved the governing fluid flow and energy equations for two immiscible and incompressible phases (water and air) which were weakly coupled by applying the Boberbeck-Boussinesq approximation. Different turbulence models, such as k−ε multiphase, k-ω SST, k-ω SST-multiphase, k-ω SST-stable, and realizable k−ε were applied. Extensive verification of the model's performance is conducted by comparing the developed model results against a diverse range of analytical and experimental data. First, a series of simulations are carried out …

Mixed Debris Interaction With Obstacle Array Under Extreme Flood Conditions, Piyali Chowdhury, Indigo Jaie Fredericks, Jesus Castaño Alvarez, Matthew Clark, Ravindra Jayaratne, J. J. Wijetunge, Alison Raby, Paul Taylor

School of Engineering, Computing and Mathematics

This investigation explores the interactions of different shaped debris with an array of obstacles under subcritical flow conditions, representative of a flood associated with a storm surge or tsunami. Panels, blocks and cylinders were used in a flow channel, as analogues for house panels, cars/containers and trees respectively, whilst some tests used a mix of debris. The backwater effect due to the blockage caused by the obstacles was most (least) significant for panels (cylinders). There was some evidence that smaller key log types and higher flow rates led to smaller dams. It was also evident that key logs formed at …

Development Of Realistic Hazard Scenarios In A Malaysian Driving Simulator For Education, Cheng Yun Quan, Sarina Mansor, Chin Ji Jian, Hezerul Abdul Karim, Ban Kar Weng

School of Engineering, Computing and Mathematics

In this paper, we present the development of a driving education prototype simulator, aiming to address dangerous traffic situations frequently encountered in daily life, particularly in urban areas like Klang Valley, Malaysia. Our initial driving simulator version focused on track-based training tailored to Malaysian driving exams, but we recognized its limitations in preparing learner drivers for real-world challenges due to the lack of risk. To add the value of study to our project, we designed three scenarios based on common dangerous situations observed in dashboard camera (dashcam) footage from Malaysian drivers. Due to the lack of reliable openly discussed methods …

Which Components Of Behavioral Weight Management Programs Are Essential For Weight Loss In People Living With Obesity? A Rapid Review Of Systematic Reviews, The Progroup Programme Team, Lily K. Hawkins, Lorna Burns, Dawn Swancutt, Shokraneh Moghadam, Jonathan Pinkney, Mark Tarrant

Peninsula Medical School

The optimal treatment and organization of care for people with obesity is one of the greatest challenges facing today's health services. While surgery and pharmacotherapy offer effective treatment options for some people with obesity, behavioral interventions are important to support long-term behavioral change. However, little is known about the most effective components of behavioral interventions, and this is especially the case for people with complex or severe obesity (i.e. body mass index [BMI] > 35 kg/m²). Accordingly, the current rapid review aimed to identify which behavior change techniques (BCTs) are effective for weight loss in adults with (severe) obesity. …

Amplifying Pcr Productivity And Environmental Sustainability Through Shortened Cycling Protocols, Matthew Pedlar, Matthew J. Emery, Philip J. Warburton

School of Biological and Marine Sciences

Since its inception in the 1980s, advancements in PCR technology using improved thermal cyclers, engineered DNA polymerases and commercial master mixes, have led to increased PCR productivity. Despite these advancements, PCR cycling protocols have largely remained unchanged over the same period. This study aimed to systemically evaluate the effect of reduced PCR cycling parameters on amplicon production. The 1466bp fragment from the 16S rRNA gene present in low-, medium- and high-CG bacteria was amplified using three commercially available PCR master mixes. The shortest cycling parameters required to successfully amplify the 16S fragment from all bacteria and master mixes comprised 30-cycles …

Shifting The Focus From Species To Individuals In Invasion Biology: Individual Differences In Jumping Behaviour, Aaron Jessop, Miguel Barbosa, Michael Morrissey

School of Biological and Marine Sciences

Dispersal is critical to population persistence, colonization and connectivity which are all critical components of invasive success. While individual propensity to disperse varies within populations, the underlying mechanisms promoting individual dispersal remain unclear. Collectively, dispersal is influenced by the environment and individual phenotype. Here we investigated individual dispersal propensity in the Trinidadian guppy, Poecilia reticulata, and related individual variation in dispersal behaviour to phenotype and social/environmental conditions. Namely, we addressed the effect of sex ratio (social/environmental factor) on the tendency for individuals to disperse across physical barriers via jumping behaviour. Jumping is vital for the dispersal of many aquatic species …

Child Protection And Family Support: Experiences In A Seaside Resort, Thomas El-Hoss, Felicity Thomas, Felix Gradinger, Ms Susanne Hughes

Peninsula Medical School

Effective Early Help services are key to halting rising rates of children in care in the UK. Yet despite family support and child welfare interventions being unequally distributed across the country, the role of ‘place’ has received limited attention in the children's social care arena. This paper examines the connections between coastal challenges, Early Help and child welfare interventions, drawing on embedded research undertaken within a Local Authority on England's coast with elevated levels of children in care. We focus on families’ experiences raising children in a seaside resort area as well as professionals’ perspectives on the place-based challenges faced …

What Is The Volume, Quality And Characteristics Of Evidence Relating To The Effectiveness And Cost-Effectiveness Of Multi-Disciplinary Occupational Health Interventions Aiming To Improve Work-Related Outcomes For Employed Adults? An Evidence And Gap Map Of Systematic Reviews, Elizabeth Shaw, Michael Nunns, Stuart G. Spicer, Hassanat Lawal, Simon Briscoe, G. J. Melendez-Torres, Ruth Garside, Kristin Liabo, Jo Thompson Coon

Peninsula Medical School

Background: In the UK, tens of millions of working days are lost due to work-related ill health every year, costing billions of pounds. The role of Occupational Health (OH) services is vital in helping workers to maintain employment when they encounter injury or illness. OH providers traditionally rely on a clinical workforce to deliver these services, particularly doctors and nurses with OH qualifications. However, the increasing demand for OH services is unlikely to be met in the future using this traditional model, due to the declining number of OH-trained doctors and nurses in the UK. Multi-disciplinary models of OH delivery, …

A Study Of Referral Bias In Nmosd And Mogad Cohorts, Miguel Leal Rato, Bo Chen, Anna Francis, Silvia Messina, Madalina Miron, Yvonne Sharawakanda, Eoin O'Sullivan, Sarah Cooper, Leonora Fisniku, Christopher Halfpenny, Roswell Martin, Jeremy Hobart, Waqar Rashid, Cheryl Hemingway, Victoria Williams, Yael Hacohen, Ruth Dobson, Sithara Ramdas, Maria Isabel Leite, Jacqueline Palace, Ruth Geraldes

Peninsula Medical School

Background: Neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD) are rare disorders often seen in highly specialized services or tertiary centres. We aimed to assess if cohort characteristics depend on the origin of the referral catchment areas serviced by our centre (i.e. local, regional or national). Methods: Retrospective cohort study using a national referral service database including local (Oxfordshire), regional (Oxfordshire and neighbouring counties), and national patients. We included patients with the diagnosis of NMOSD, seronegative NMOSD or MOGAD, followed at the Oxford Neuromyelitis Optica Service. Results: We included 720 patients (331 with MOGAD, 333 with …

Emigration Of Post-Spawned Twaite Shad Alosa Fallax, An Anadromous And Iteroparous Fish, In A Highly Fragmented River, Mark I.A. Yeldham, J. Robert Britton, Charles Crundwell, Peter Davies, Jamie R. Dodd, Andrew D. Nunn, Randolph Velterop, Jonathan D. Bolland

School of Biological and Marine Sciences

Anthropogenic barriers are widely known to negatively impact the spawning migrations of anadromous fishes, by delaying or preventing passage upstream. Although the impacts of barriers on emigrating post-spawned adults are less well studied, they could potentially impact the fitness and subsequent return rates of iteroparous species. In this study, passive acoustic telemetry was used to track the emigrations of 53 twaite shad Alosa fallax in the River Severn basin in their first spawning migration a year after being tagged, giving insights into their emigration movements and the impacts of anthropogenic weirs on these movements. A. fallax began their emigrations after …

Inconsistent Bioreceptivity Of Three Mortar Mixes In Subtidal Sites, Jessica R. Bone, Alice E. Hall, Rick Stafford, Roger J.H. Herbert

School of Biological and Marine Sciences

Concrete is extensively used in coastal engineering and development which, in addition to its high carbon footprint, threatens intertidal habitats and ecosystems. Eco-engineering addresses this by designing habitat features into coastal infrastructure. The chemical bioreceptivity of cement has been shown to vary, but ordinary Portland cement is generally considered to be the least bioreceptive. In this study, we compare two low carbon mortars (a natural, single source cement (VP), and an ordinary Portland cement/ ground granulated blast furnace slag blend (GGBS)) with an ordinary Portland cement-based control mix (OPC). The three mortars were made into smooth blocks which were secured …