Digital Commons Network^™

Impact Of Hdac Inhibitors On The Efficiency Of Cardiomyocyte Differentiation, Lauren Mary Sargent

Honors Theses and Capstones

Heart disease and injury is the leading cause of death worldwide, with much of its severity caused by the low regenerative capacity of cardiomyocytes (CMs). One of the strategies to counteract the poor regeneration of CMs is the production of CMs via differentiating stem cells. However, the low efficiency of obtaining CMs from stem cells is an issue because there are numerous inconsistencies in the process. Histone deacetylase (HDAC) inhibitors have been researched as ways to increase efficiency of CM differentiation by increasing histone acetylation, and thereby allowing differentiation to occur more efficiently. In this study, the HDAC inhibitor, trichostatin …

Jury Decision-Making: Do Racial Attitudes And Victim And Offender Race Make A Difference?, Charlotte A. Kettyle, Ellen S. Cohn

Honors Theses and Capstones

No abstract provided.

Presidential Adjudication, Emily S. Bremer

Journal Articles

Over the last several decades, administrative law has recognized an expanding role for the President in controlling agency decision making. Agency adjudication—and especially formal hearings conducted under the Administrative Procedure Act (“APA”)—have been viewed as properly insulated from this development. To protect due process, the APA established a regime for ensuring that competent, impartial Administrative Law Judges (“ALJs”) preside over formal hearings. The regime includes two apparent levels of for-cause removal protection for ALJs combined with robust agency head control over the policymaking aspects of formal adjudication. Today, the regime is in peril because it appears to be inconsistent with …

Morphometry Of The Superior Ophthalmic Vein Unaffected By Dilating Factors, Farida Mehrhoff, Melissa Zolnierz, Alla Barry, Shelby Kuhnert, Mary Kilmer, Dmitry E. Tsyplakov, Robert Hillard

Faculty and Staff Publications

Context:
Data on the superior ophthalmic vein (SOV) dilation captivate the attention of neurologists as an early sign of several neurovascular disease manifestations, but measurements vary widely in publications.

Aims:
This study attempts to shed light on disparate data and develop more stringent criteria for determining the dilation of these veins.

Settings and Design:
To this end, 44 orbits of 25 formalin-embalmed human cadavers without risk factors for SOV dilation were dissected.

Materials and Methods:
The SOV branching pattern and length were photographed, and multiple segments were analyzed microscopically, histologically, and statistically.

Statistical Analysis Used:
Simple descriptive statistics as well …

Ideological Leanings In Likely Pro Bono Biglaw Amicus Briefs In The United States Supreme Court, Derek T. Muller

Journal Articles

Each term, the United States Supreme Court receives hundreds of amicus briefs filed in merits docket cases. Many of the largest law firms file amicus briefs before the United States Supreme Court. These amicus briefs are often pro bono, which means the clients do not pay for the firm to file the brief. That pro bono work can quickly total millions of dollars of legal briefing subsidized by the law firm. And pro bono work often reflects the law firm’s desire to work for its prior commitments to what it identifies as the "public good."

Controversies have arisen in recent …

Developing A Professional Identity: Lessons For Women, Bipoc, And First Generation Law Students From The Canaries In The Coalmines, Christine Venter

Journal Articles

From the Article

This Article explores the concept of professional identity formation in the law, particularly as it pertains to women and lawyers of color. The topic of professional identity formation is an understudied area in legal education, despite the ABA’s new Standard 303(b)(3), which requires law schools to provide substantial opportunities for the development of professional identity. In the legal field, professional identity is often conflated with professionalism, which leads to confusion about how law schools should best prepare their students for their professional lives, and fails to fully equip students to join the profession.

Studies from other professions …

Children's Moments Of "Becoming" In Classrooms: Spatial Production And Multiliteracy Practices, Seongryeong Yu

Teaching & Learning Faculty Publications

While immigrant children’s identity negotiation and their sense of belonging are increasingly highlighted, existing literature remains largely focused on language abilities and identity struggles, often emphasizing rigid definitions of “identity” grounded in blood, language, and culture. Drawing on findings from my dissertation, this comparative ethnographic case study examines the fluidity of identity through literacy practices that help children construct meaning and foster belonging. By analyzing how 10-year-old students’ literacy practices interact with physical and social environments at school, I discuss shared expressions of emotions, power dynamics, the role of language, and variations in the use of cultural materials. These moments …

Table Of Contents (Vol. 81, Issue 3)

University of Colorado Law Review

No abstract provided.

Integrating Generative Artificial Intelligence With Systems Architecting Diagram Creation: Advancement, Challenges, Opportunities And Future Perspectives, Cansu Yalim, Holly H. Handley

Engineering Management & Systems Engineering Faculty Publications

Generative AI (GenAI) serves as a powerful tool that can create a wide range of content, including but not limited to text, speech, images, code, videos, and 3D models. ChatGPT stands out as a particularly appealing Generative Pretrained Transformer (GPT) model that offers supplementary capabilities through GPTs and plugins. These extensions enable users to engage with the chatbot and improve its functionality, surpassing mere content generation. Our study delves into the potential of ChatGPT, specifically GPT-4, to expedite the creation of diagrams to support the system architecting process. To this end, we explored the use of ChatGPT's Diagrams Show Me …

Improving Neuropathological Analysis With Aβgan: Addressing Morphology Imbalance For Efficient Alzheimer's Disease Diagnosis, Sujatha Alla, Prasanthi Chidipudi, Nagesh Bheesetty, Vedvikash Reddy Velur, Joshit Mohanty, Puneeth Bheesetty, Marisha Jmukhadze, Narendra Lakshmana Gowda, Sai Gireesh Komaragiri

Engineering Management & Systems Engineering Faculty Publications

Histopathologists are experiencing a digital revolution in their field thanks to the digitization of Whole Slide Images (WSIs), which are microscope slides of tissue that can measure gigapixels in size. With so much high resolution data at their disposal, computer vision techniques can now be used to automate laboratory processes, create visual standards, and increase analysis throughput, all of which reduce the workload of pathologists [1]. The "gold" standard in neuropathology, particularly for Alzheimer's Disease- is pathological diagnosis made by looking at White Matter Inclusions (WSIs) in brain tissue. Semi-quantitative scoring in accordance with the standards established by the Consortium …

Domestic Supply (A Feminist Proposal), Jennifer S. Hendricks

Publications

No abstract provided.

The Realization Rule As A Legal Standard, Sloan G. Speck

Publications

The realization “rule” in tax law is better characterized as a legal standard. This characterization matters after the Supreme Court’s decision in Moore v. United States, which sets the stage for future courts to decide that the Constitution mandates realization— an identifiable event before accrued income is reportable by taxpayers. The stakes of a constitutional realization requirement are underappreciated. Because current statutory law embeds realization as a background principle, a constitutional realization requirement would operate as a taxpayer-initiated antiabuse doctrine—a sword that taxpayers could use selectively to invalidate parts of the Internal Revenue Code and Treasury Regulations. This novel constitutional …

Invisible Adjudication In State Supreme Courts, Adam B. Sopko

Publications

As the U.S. Supreme Court continues retrenching important constitutional rights, interest is shifting to state courts and constitutions to serve as a backstop. More and more, state supreme courts are at the center of some of our most important debates of law and policy, resolving questions concerning bodily autonomy, democracy, the environment, and more. The increased attention on state supreme courts highlights the complexity and nuance that attend these institutions and reveals our limited understanding of how they operate and influence society. This Article examines one such aspect of state supreme court practice: the shadow docket. While the U.S. Supreme …

Immigration Detention Abolition And The Violence Of Digital Cages, Sarah Sherman-Stokes

University of Colorado Law Review

The United States has a long history of pernicious immigration enforcement and surveillance. Today, in addition to more than 34,000 people held in immigration detention, Immigration and Customs Enforcement (ICE) shackles and surveils an astounding 376,000 people under its “Alternatives to Detention” (“ATD”) program. The number of people subjected to this surveillance has grown dramatically in the last two decades, from just about 1,700 in 2005. ICE’s rapidly expanding Alternatives to Detention program is a “digital cage,” consisting of GPS-outfitted ankle shackles and invasive phone and location tracking. Government officials and some immigrant advocates have characterized these digital cages as …

Federal Indian Law As Method, Matthew L.M. Fletcher

University of Colorado Law Review

No abstract provided.

Legal Asynchrony: Constitutional “Bridges” Inverting Elemental U.S. Technology, Steven Ferrey

University of Colorado Law Review

The 2022 Biden Inflation Reduction Act (“IRA”) and the 2021 Infrastructure Investment and Jobs Act (“IIJA”), together providing for an unprecedented $1.7 trillion in spending, were enacted to construct a sustainable legal U.S. exit ramp from what the Secretary-General of the United Nations recently described as a “highway to climate hell with our foot still on the accelerator.” This Article analyzes a critical legal missing link in these Acts that is now causing the U.S. economy to do the opposite of its intended climate change mitigation, given: • A necessary eight-fold increase in current renewable electric power, requiring adding the …

Force Majeure And The Law Of The Colorado River: The Confluence Of Climate Change, Contracts, And The Constitution, Mary Slosson

University of Colorado Law Review

Climate change is causing significant, permanent changes to the natural world. In the Colorado River Basin, experts forecast that rising temperatures will cause the spread of a drier, more arid climate across the region. The effects of this desertification are already being felt: less rainfall, the loss of deciduous forests, wildfires that engulf urban areas, and a projected 20 to 30 percent reduction in flows on the Colorado River by mid-century. The net effect is an existential crisis for the forty million people that reside in the Colorado River’s watershed. Mitigating the effects of climate change requires swift action. However, …

Estate To State: Pay-To-Stay Statutes And The Problematic Seizure Of Inherited Property, Brittany L. Deitch

University of Colorado Law Review

Pay-to-stay statutes allow states to recover their incarceration-related expenditures from those who are currently or have formerly been incarcerated. Mass incarceration is expensive, and states have aimed to shift this financial burden from their taxpayers and government coffers to the individuals who experience incarceration. Although pay-to-stay laws take many forms, in general, they authorize the government to seek recompense for an individual’s incarceration costs from the currently or formerly incarcerated person’s assets and income. Many states permit the seizure of inherited property to satisfy this legal financial obligation. Pay-to-stay laws have survived constitutional challenges thus far, but some state legislatures …

Colonizing Queerness, Jeremiah A. Ho

University of Colorado Law Review

This Article investigates how and why the cultural script of inequality persists for queer identities despite major legal advancements such as marriage, anti-discrimination, and employment protections. By regarding LGBTQ legal advancements as part of the American settler colonial project, I conclude that such victories are not liberatory or empowering but are attempts at colonizing queer identities. American settler colonialism’s structural promotion of a normative sexuality illustrates how our settler colonialist legacy is not just a race project (as settler colonialism is most widely studied) but also a race-gender-sexuality project. Even in apparent strokes of progress, American settler colonialism’s eliminationist motives …

Investigating The Roles Of Plants, Fungi, And Biocrusts In Nutrient Movement Within Dryland Ecosystems, Catherine E. Cort

Open Access Theses & Dissertations

In dryland ecosystems, plant productivity and microbial decomposition are often separated in space and time due to the asynchronous availability of soil moisture and organic matter inputs. It has been proposed that fungi play a key functional role in connecting these cycles by facilitating movement of water, carbon (C), and nitrogen (N) through a network of shared hyphae between plant roots and biological soil crust (biocrust) communities at the soil surface. This connection, also known as the â??fungal loop,â?? effectively re-couples processes of nutrient release and uptake between primary producers and minimizes ecosystem N losses due to leaching, erosion, and …

Predatory Publishing And Global Scholarly Communications, Monica Berger

Publications and Research

redatory publishing is a complex problem that harms a broad array of stakeholders and concerns across the scholarly communications system. It shines a light on the inadequacies of scholarly assessment and related rewards systems, contributes to the marginalization of scholarship from less developed countries, and negatively impacts the acceptance of open access.   To fix what is broken in scholarly communications, academic librarians must act as both teachers and advocates and partner with other stakeholders who have the agency to change how scholarship is produced, assessed, and rewarded. Predatory Publishing and Global Scholarly Communications is a unique and comprehensive exploration of …

Is The Gi Bill Enough? An Exploratory Analysis Of Student Veteran Borrowing In College, Kim E. Bullington, Kaycee L. Bills, David J. Thomas, William L. Nuckols, Joshua L. Howell

Educational Leadership & Workforce Development Faculty Publications

In the United States, many student veterans use their GI Bill benefits to help fund their postsecondary education; however, when the GI Bill is not enough, student veterans may turn to grants and loans to subsidize their financial needs. This study examines the degree and extent to which Pell Grants and student loans are being used by student veterans using data pulled from the National Center for Education Statistics’ Baccalaureate and Beyond dataset. We found that Pell Grant awards were higher for student veterans with disabilities as well as Blacks and that a student’s age contributed to the overall amount …

National Science Foundation- Experiential Learning For Emergent And Novel Technologies (Exlent): A Response To Emtech Workforce Shortages, C. Tomovic, M. Tomovic, M. Yang, S. Bawab

Educational Leadership & Workforce Development Faculty Publications

This paper presents how critical workforce shortages in the emerging STEM fields of technology (EmTech), i.e., advanced manufacturing, artificial intelligence, biotechnology, quantum information science, semiconductors, microelectronics, alternative energy, etc., are impacting the workforce in the United States. The demands for EmTech graduates have become so great that many employers have changed their hiring criteria; over 60% of today’s high-need EmTech employers no longer require new hires to have an earned bachelor’s degree. Instead, they are asking applicants to demonstrate that they can execute professional competencies or provide validated certificates as evidence of their expertise.

In an attempt to alleviate this …

The Minerals Challenge For Renewable Energy, Mark Squillace

Publications

One potential obstacle to a successful energy transition involves the critical minerals used in production of photovoltaic solar panels, wind turbines, electric vehicles, and batteries. A substantial portion of these will have to come from new and expanded mining operations around the world. But mining is controversial, in part due to the past failures of operators to protect communities and the environment. This Article considers how nations can responsibly identify, source, and process these minerals, and then deploy them in renewable energy products. Its scope is global, but U.S. laws and policies take center stage with a nod to the …

Constructing Ai Speech, Margot E. Kaminski, Meg Leta Jones

Publications

Artificial Intelligence (AI) systems such as ChatGPT can now produce convincingly human speech, at scale. It is tempting to ask whether such AI-generated content “disrupts” the law. That, we claim, is the wrong question. It characterizes the law as inherently reactive, rather than proactive, and fails to reveal how what may look like “disruption” in one area of the law is business as usual in another. We challenge the prevailing notion that technology inherently disrupts law, proposing instead that law and technology co-construct each other in a dynamic interplay reflective of societal priorities and political power. This Essay instead deploys …

Trans Animus, Scott Skinner-Thompson

Publications

No abstract provided.

Introduction To The Symposium On Rabiat Akande, "An Imperial History Of Race-Religion In International Law", S. James Anaya, Adrien K. Wing

Publications

No abstract provided.

The Significance Of The Un Declaration On The Rights Of Indigenous Peoples, S. James Anaya

Publications

No abstract provided.

Valuing Social Data, Amanda Parsons, Salome Viljoen

Publications

Social data production—accumulating, processing, and using large volumes of data about people—is a unique form of value creation that characterizes the digital economy. Social data production also presents critical challenges for the legal regimes that encounter it. This Article provides scholars and policymakers with the tools to comprehend this new form of value creation through two descriptive contributions. First, it presents a theoretical account of social data, a mode of production that is cultivated and exploited for two distinct (albeit related) forms of value: prediction value and exchange value. Second, it creates and defends a taxonomy of three “scripts” that …

Barring Judicial Review, Laura E. Dolbow

Publications

Whether judicial review is available is one of the most hotly contested issues in administrative law. Recently, laws that prohibit judicial review have sparked debate in the Medicare, immigration, and patent contexts. These debates are continuing in challenges to the recently created Medicare price negotiation program. Yet despite debates about the removal of judicial review, little is known about how often, and in what contexts, Congress has expressly precluded review. This Article provides new insights about express preclusion by conducting an empirical study of the U.S. Code. It creates an original dataset of laws that expressly preclude judicial review of …