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Cinnamic Acid Lowers Blood Pressure And Reversesvascular Endothelial Dysfunction In Rats, Abdul Jabbar Shah, Hafiz Misbah-Ud-Din Qamar, Umme Salma, Taous Khan

Journal of Food and Drug Analysis

Cinnamic acid (CA) possesses important cardiovascular effects such as cardioprotective, antiatherogenic, anti-hyperlipidemic and antioxidant, which predicts its potential role in the treatment of hypertension. The study wasexecuted to investigate the antihypertensive potential of CA in Sprague Dawley (SD) rats followed by evaluation indiverse vascular preparations. Invasive blood pressure monitoring technique was used in normotensive and hyper-tensive rats, under anesthesia. Isolated aortic rings from rat and rabbit, Langendorrf's perfused isolated rabbit heart and guinea-pig right atria were used to probe the underlying mechanisms. The responses were recorded with pressure andforce transducers connected to PowerLab Data Acquisition System. Intravenous administration of CA …

Fluorescent “On–Off–On” Sensor Based On N, P Co-Doped Carbon Nanoparticles For Specific Detection Of Fe3+ And Ascorbic Acid, Li Li, Ming Zhang, Xiang Liu, Shaoqing Zhu

Journal of Food and Drug Analysis

Ascorbic acid (AA) is used as a food additive for its antibacterial and antioxidant properties. However, excessive intake of AA is harmful to humans. Therefore, the detection of Fe³⁺ and AA is generally recognized to be meaningful. In this work, a one-step hydrothermal tactics is developed for the preparing nitrogen and phosphorus co-doped carbon nanoparticles (N, P-CNPs) by using sucrose and ammonium orthophosphate as raw materials. The N, P-CNPs not only exhibited an enhanced fluorescent efficiency with a relatively high quantum yield up to 28%, but also showed satisfactory stability, water solubility and photostability. The fluorescence of N, P-CNPs …

Aromatic Compounds And Organic Acids Identified From Ganoderma Formosanum Exhibit Synergistic Anti-Melanogenic Effects, Chen-Che Hsieh, Chih-Yao Hou, Hsiao-Yun Lei, Darin Khumsupan, Huey-Jine Chai, Pek-Kui Lim, Cheng-Chih Hsu, Sz-Jie Wu, Kai-Wen Cheng, Yi-Chen Chen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

This study reveals the anti-tyrosinase activity of Ganoderma formosanum extracts, pinpointing compounds including gluconic acid, mesalamine, L-pyroglutamic acid, esculetin, 5-hydroxyindole, and salicylic acid, as effective melanin production inhibitors in melanoma cells and zebrafish embryos. Furthermore, multiple molecular docking simulations provided insights into interactions between the identified compounds and tyrosinase, increasing binding affinity up to -16.36 kcal/mol. The enhanced binding of identified compounds to tyrosinase facilitated synergistic inhibitory effects on melanin production. This study highlights the potential of GFE-EA as a source of natural tyrosinase inhibitors and contributes to understanding the role of active compounds extracted from G. formosanum.

Bitter Acids From Humulus Lupulus L. Alleviate D-Galactose Induced Osteoblastic Senescence And Bone Loss Via Regulating Akt/Mtor-Mediated Autophagy, Tian-Shuang Xia, Sheng-Yan Xu, Li-Yong Lai, Yi-Ping Jiang, Na-Ni Wang, Hai-Liang Xin

Journal of Food and Drug Analysis

Bitter acids (BA) are main component of Humulus lupulus L. (hops). They are known for beer brewing and have various biological and pharmacological properties, especially the bone-protective effect confirmed by our previous in vivo study. Here we aimed to elucidate the anti-senior osteoporosis (SOP) effect of BA on osteoblasts and explore its underlying mechanism. In vitro SOP model was established by D-galactose (D-gal) injured osteoblasts, and the bone formation markers and apoptosis level were measured. mCherry-EGFP-LC3 adenovirus infection and autophagic markers including beclin1 and LC3 proteins were detected to investigate the autophagy level in osteoblasts. To further verify whether BA …

The Effects Of Fermentation By Different Species Oflactic Acid Bacteria On Betalains And Polyphenol Profile And In Vitro Bioactive Potential Of Red Beetroot Juice, Tomasz Sawicki, Monika Jabłońska, Małgorzata Starowicz, Lucyna Kłębukowska, Wioletta Błaszczak

Journal of Food and Drug Analysis

In the current study, the effects of fermentation by Lactobacillus acidophilus, Levilactobacillus brevis or Lactiplantibacillus plantarum (La/Lb/Lp, 1-2.5%) and incubation (30/37℃, C1/C2) of red beetroot juice on the profile of betalains and polyphenols (UHPLC-DAD-MS), and antioxidant capacity using photochemiluminescence (PCL) and spectrophotometric assays (DPPH/ABTS) was investigated. Additionally, anti-glycaemic (anti-AGEs) and anti-cholinergic (anti-AChE) potential in vitro was analysed. Fermentation distinctly initiated isobetanin and neobetaninformation and enhanced flavonoid concentration, emphasising rutin, kaempferol and (+)-catechin. The fermented juices inhibited protein glycation in the BSA-GLU model and showed high DPPH and ABTS values. LP2.5% juice was the only one indicating anti-AChE potential.

Determination And Validation Of Polycyclic Aromatichydrocarbons (Pah4) In Katsuobushi, Plant-Basedfood Supplements, And Cocoa Bean Shells Using Gc-Ms/Ms, Chia-Hsin Liu, Yu-Ning Shin, Ya-Chun Chou, Guan-Jhih Peng, Ying-Ru Shen, Nu-Ching Lin, Shu-Han Chang, Ya-Min Kao, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Polycyclic aromatic hydrocarbons (PAHs) are primarily generated through the incomplete combustion or pyrolysis oforganic materials in various industrial processes. Foods may become contaminated with environmental PAHs found inair, soil, or water, or through industrial food processing methods such as smoking, roasting, drying, and grilling. The Ministry of Health and Welfare in Taiwan has established maximum levels for benzo[a]pyrene (BaP) and indicativevalues for BaP as well as PAH4 (the sum of benz[a]anthracene, chrysene, benzo[b]fluoranthene, and benzo[a]pyrene) infoods as operational guidelines. The current study developed an analytical method for simultaneous determination of PAH4 levels in katsuobushi (dried bonito flakes), cocoa bean shells, …

A Novel Selective Medium For Isolation Of Limosilactobacillus Reuteri From Dietary Supplements, Yu-Ting Wang, Jyue-Wei Chuang, Ming-Sian Wu, Min-Cheng Wang, Yu-Cheng Yang, Jun-Jie Yang, Shih-Ting Chiou, Chun-Hsien Li, Che-Yang Lin, Shou-Chieh Huang, Su-Hsiang Tseng, Der-Yuan Wang

Journal of Food and Drug Analysis

Limosilactobacillus reuteri is a probiotic bacterium known for its numerous beneficial effects on human health and is commonly utilized in various dietary supplements. Previously, we encountered difficulties in isolating L. reuteri from retail dietary supplements containing complex probiotic compositions by using non-selective media such as de Man, Rogosa, and Sharpe (MRS) agar. Our findings reveal that MRS agar using D-gluconic acid as the carbon source and peptone from soymeal as the nitrogen source provid a growth advantage for L. reuteri. Furthermore, all the tested L. reuteri strains exhibit higher resistance to oxacillin compared to non-L. reuteri strains and …

Herbal Nanoemulsions In Cosmetic Science: A Comprehensive Review Of Design, Preparation, Formulation, And Characterization, Benni Iskandar, Ta-Wei Liu, Hui-Ching Mei, I-Chih Kuo, Meircurius Dwi Condro Surboyo, Hsiu-Mei Lin, Ching-Kuo Lee

Journal of Food and Drug Analysis

The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to …

Therapeutic Approach Of Carbon Nanotube: Revolutionize Nanomaterial In Biomedical And Pharmaceutical Sector, Shovan Ghosh, Vivek Dave, Pranay Wal

Journal of Food and Drug Analysis

Carbon nanotubes (CNTs) has emerged as a promising nanomaterial with a wide range of potential applications due to their unique structural, mechanical, electrical, and thermal properties. However, numerous obstacles must be overcome for CNTs to be used successfully, including low solubility, aggregation, and a lack of specialized functions. Diverse techniques have been developed for the manufacture, purification, and functionalization of CNTs in order to overcome these issues. The main aim of this review article is to provide brief knowledge about CNTs and strategies to use this revolutionized nanomaterial in drug delivery. Prepare CNTs cannot be directly used as drug carrier …

Updates On The Conversion Of Nanosuspensions To Solid Oral Dosage Forms, Anastasia Tsiaxerli, Elisavet Vardaka, Christos Moutroupidis, Kevin M.G. Taylor, Kyriakos Kachrimanis, Maria Malamatari

Journal of Food and Drug Analysis

Pharmaceutical nanosuspensions, also called nanocrystals, are heterogeneous mainly aqueous dispersions of insoluble drug particles stabilised by surfactants and/or polymers. Nanosuspensions as liquid formulations suffer from instability. Solidification of nanosuspensions to solid dosage forms is a way to combine the advantages of nanocrystals with the advantages of the solid state. In this review, advances regarding stabilisation and production of nanosuspensions are briefly covered. Updates on the methods used to convert nanosuspensions to solid oral dosage forms (e.g., powder, granules, pellets, tablets, and films) are presented in depth. From these methods, spray drying and freeze drying are widely used. Granulation and hot-melt …

Integrating Image Data Fusion And Resnet Method For Accurate Fish Freshness Classification, Yahya Layth Khaleel, Mustafa Abdulfattah Habeeb, Ghadeer Ghazi Shayea

Iraqi Journal for Computer Science and Mathematics

Fish freshness classification is critical for protecting public health and ensuring efficient economic, regulatory and environmental sustainability. Classifying accurately reduces the risk of foodborne illness, protects product quality, builds consumer trust and supports sustainable resource conservation through waste minimization. However, the traditional methods for determining fish freshness are variable, time consuming and subjective, precluding practical use. This research presents an improved framework that integrates image data fusion and a deep learning ResNet model to differentiate fresh and nonfresh fish. From multiple sources, a comprehensive dataset including 16,640 samples was curated, and data fusion was used to increase the diversity and …

Okinawa Studies In Taiwan Under Japanese Rule: Focusing On The Use Of The Word “Nantō”, Takahiro Teshima

Kritika Kultura

In the modern period, certain research on Okinawa utilizing the noun “nantō,” which signified the southern islands, was known as Nantō studies. It accentuated Okinawa as the southernmost portion, or one component, of Japan, emphasizing Okinawa’s identity as a place that preserves old Japanese culture, based on the hypothesis that culture originates in the center of a cultural region and spreads to the frontier. This article examines the possibilities and limitations of Nantō studies in colonial Taiwan. Under the academic guidance at Taihoku Imperial University, including Japanese history, which had previously received less attention in prior research, Nantō studies could …

Why Should We Care About Care? Popular Care-Narratives And The Dependency Critique, Jay Hee-Jeong Sohn

Kritika Kultura

This essay analyzes representations of care and dependency in popular narratives from the Global North, re-appropriating Eva Feder Kittay’s “dependency critique” as an analytical lens. Through examinations of films like Plan 75, I Care a Lot, The Bacchus Lady, Her, I’m Your Man, and La Maison de Himiko, it explores how these narratives engage with contemporary care issues, including the commodification and gendering of care work, fantasies of automated care, and alternative care models beyond traditional family structures. The analysis reveals how popular culture both reflects and shapes societal attitudes towards care, dependency, and human dignity. By interrogating these representations, …

Against Social Abjection: Offred’S Empowering Narration Of The Handmaid's Tale (1985), Saeedeh Esmailzadeh, Maryam Soltan Beyad

Kritika Kultura

This scholarly investigation explores how Offred, the central character in Margaret Atwood’s The Handmaid’s Tale, endeavors to undermine the abjectifying apparatus of Gilead through the utilization of her narrative as a form of resistance. Drawing inspiration from Imogen Tyler’s concept of social abjection, the initial segment of this study will concentrate on the implementation of policies aimed at abjection within the society of Gilead. It will elucidate that the Gileadean regime employs tactics such as fostering disgust consensus, enforcing social hierarchies, propagating territorial stigmatization, and asserting control over language to execute the mechanisms of social abjection. This procedure serves to …

Abide With Me: A Social Ecological Perspective In Selected Pandemic Poetry, Amany Abdullah Abdelaziz Eldiasty, Eman Ebeida Mansour

Kritika Kultura

This article traces the core principles of the social ecological approach, namely, the interconnectedness of social communities and their integration into the natural world in selected poems written by contemporary poets during the coronavirus pandemic and collected in Poetry in Response to the Pandemic, published in 2020 by St. Michael’s Episcopal Church in Arlington, VA. Applying a qualitative approach that integrates interpretive and analytical readings of the selected poems based on Daniel Stokols’s views on social ecology, it argues that although social networks facilitated community engagements during the pandemic (particularly during the lockdown), virtual reality failed to sustain the social …

Alikhan Bokeikhan’S Literary Preservation Of Kazakh Identity Against Colonial Ideology, Assem Osken, Dikhan Qamzabekuly, Bekarys Nuriman

Kritika Kultura

In the history of the world, imperialist countries happened to pursue a policy of colonization to destroy ethnic consciousness, culture, language, and knowledge. This article comprehensively analyzes the literary works of the national leader Alikhan Bokeikhan, who opposed the policy of the Russian Empire in the 19th century and its successor, the Soviet government in the 20th century that was aimed at gradually destroying the Kazakh people as a distinct group of Kazakh people. The research shows that literary translations, critical articles, and folklore samples of Bokeikhan greatly contributed to the preservation of Kazakh language, religion, culture, national education and …

The Day The Dancers Stayed: Expressive Forms Of Culture In United States, Theodore S. Gonzalves

Kritika Kultura

How have performances developed by Filipino Americans over the twentieth century conveyed important lessons about culture, nation, and community? In other words, what do Filipino American cultural performances have to say about the formation of “national identity” and “community”? I select three contexts to highlight these changes: the postindustrialization of the US economy; the reaction to race, taxes and education in the Bakke vs. UC Board of Regents decision; and the political realignment of the Reagan democrats. We see the continued immigration of Filipino so-called “professional” families to the United States. Their children seek senses of themselves amidst attacks on …

Poinsettias, Danton Remoto

Kritika Kultura

No abstract provided.

Anti-Us Imperialism As Assertion Of Black Subjectivity At The Turn Of The Last Century, Lorenzo Alexander L. Puente

Kritika Kultura

US imperialism of the Philippines at the turn of the last century raised difficult and painful issues for African Americans struggling to gain justice and equal rights in American society. Kelly Miller, an African American academician and active polemicist for Negro rights, wrote in 1900, at the beginning of the Philippine American War, his essay “The Impact of Imperialism on the Negro Race” to exhort his fellow black Americans to oppose the US colonization of the Philippines and to support Philippine independence. Miller saw through the American government’s policy of “benevolent assimilation” toward the Philippines and recognized its racist underpinnings. …

A Mini Review Of Plant Tissue Culture: The Role Of Media Optimization, Growth Regulators In Modern Agriculture, Callus Induction And The Applications, Norrizah Jafaar Sidik, Hasan M. Agha, Abdulmutalib Alabeed Alkamil, Muneer Mohammed Saleh Alsayadi, Amjad Abdulhadi Mohammed

AUIQ Complementary Biological System

Plant tissue culture is an innovative biotechnological approach developed to meet the escalating global demand for agricultural production with enhanced nutritional value. This aseptic, in vitro technique allows for the cultivation of plant cells, tissues, or entire plants under controlled environmental and nutritional conditions, facilitating the generation of genetically identical clones. The method is indispensable in preserving endangered plant species, boosting crop yield and quality, and enabling year-round production of disease-free plants. Central to plant tissue culture is the composition of the growth medium, which must include a precise balance of macronutrients, micronutrients, amino acids, vitamins, and plant growth regulators …

How Can Research And Advocacy Support Play-Based Early Learning Environments That Foster Whole Child Development To Advance Equity?, Emily E. Schlemmer

Graduate Teacher Education

This paper examined research about the lack of play in early childhood and how early childhood educators and others could bring play back into classrooms equitably. Play was a developmentally appropriate practice in early childhood classrooms. “We have in us a natural innate built-in drive designed to push us to learn and experience important principles of creativity, things like; curiosity, discovery, exploration, experimentation, communicating, and socializing. This instinctive drive is called play” (Skaggs and Twede, 2023, p.167). Play allowed learners to grow academically, socially, emotionally, and physically. Bendixen-Noe (2010) stated that the importance of play in learning was known and …

Winter Commencement, 2024, Marshall University

Marshall University Commencement

Program for the Commencement of Marshall University, Saturday, December 14, 2024 held at the Mountain Health Arena in Huntington, West Virginia.

2024 Commencement Program - Fall, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2025 Spring Commencement program for Morehead State University.

2024 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.

Phase Ii Trial Of Blood-Brain Barrier Permeable Peptide-Paclitaxel Conjugate Ang1005 In Patients With Recurrent High-Grade Glioma, Manmeet Ahluwalia

All Publications

Background: This study is a phase II clinical trial to evaluate the efficacy, safety, and tolerability of the blood-brain barrier (BBB) permeable peptide-paclitaxel conjugate ANG1005 in patients with recurrent high-grade glioma (HGG) (NCT01967810).

Methods: Seventy-three patients were enrolled in 3 separate arms-recurrent glioblastoma (GBM) (Arm 1), bevacizumab refractory GBM (Arm 2), and grade 3 anaplastic gliomas (AGs) (Arm 3). The study was started in October 2013, and the data were locked on September 29, 2017. Safety was evaluated for all three arms (n = 73), and the primary endpoint for Arms 1 and 3 was objective response …

Society Of American Foresters (Saf) Academic Publications As They Relate To The Curriculum Standards For Saf Forestry Program Accreditation: A Content Analysis, Lisa M. Bentley

Electronic Theses and Dissertations

Goals that impact decision-making components within academic programs in the university system have the potential to define and change the direction of a field of study, and, with that, should be thoughtfully approached with a certainty of evidence that supports responsible paradigms in forestry education. Periodic revision of the standards for accreditation by SAF influences institutional expectations that result in shifts in forestry education and should be consistent with professional forestry standards. The methodology utilized in this research contextualizes data from a sociological perspective intentionally as a method to holistically integrate data as evidence to support the interpretation of Society …

2024 Fall Commencement, Harding University

Commencement Programs

Program for the Harding University Commencement on December 14.

Commencement Speaker: Dr. Jim Martin

Investigating The Protective Role Of Breastfeeding Against Postpartum Depression, Aysha Paxman, Claire Jansen

Physician Assistant Capstones, 2020-current

No abstract provided.

Improved Detection Of Great Lakes Water Quality Anomalies Using Remote Sensing, Karl Bosse, Robert Shuchman, Michael Sayers, John Lekki, Roger Tokars

Michigan Tech Publications

Due to their immense economic and recreational value, the monitoring of Great Lakes water quality is of utmost importance to the region. Historically, this has taken place through a combination of ship-based sampling, buoy measurements, and physical models. However, these approaches have spatial and temporal deficiencies which can be improved upon through satellite remote sensing. This study details a new approach for using long time series of satellite remote sensing data to identify historical and near real-time anomalies across a range of data products. Anomalies are traditionally detected as deviations from historical climatologies, typically assuming that there are no long-term …

Nutritional Composition Of Mucuna Pruriens Var. Utilis (Velvet Bean) Seeds Grown In Nanyumbu District, Tanzania, Florence Boniface, Stephen I. Nnungu, Washa B. Washa

Tanzania Journal of Science

In tropical countries, Mucuna seeds have been utilized to promote better health and ensure a stable food supply. The use of Mucuna pruriens var. utilis seeds in Tanzania has prompted an evaluation of the nutritional composition of two common cultivars grown in the Nanyumbu district. Mucuna seed samples (black-reddish brown and black-greyish) were collected and analyzed for their nutritional content using standard extraction and spectrophotometric techniques. Data analysis was conducted using GraphPad InStat 3.0 software, with a t-test employed to compare means at a 95% confidence level. The results indicated that the differences in nutritional parameters between the black-reddish brown …