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Articles 6781 - 6810 of 43969
Full-Text Articles in Entire DC Network
Variant Surface Protein Gp60 Contributes To Host Infectivity Of Cryptosporidium Parvum, Muxiao Li, Fuxian Yang, Tianyi Hou, Xiaoqing Gong, Na Li, L David Sibley, Yaoyu Feng, Lihua Xiao, Yaqiong Guo
Variant Surface Protein Gp60 Contributes To Host Infectivity Of Cryptosporidium Parvum, Muxiao Li, Fuxian Yang, Tianyi Hou, Xiaoqing Gong, Na Li, L David Sibley, Yaoyu Feng, Lihua Xiao, Yaqiong Guo
2020-Current year OA Pubs
Biological studies of the determinants of Cryptosporidium infectivity are lacking despite the fact that cryptosporidiosis is a major public health problem. Recently, the 60-kDa glycoprotein (GP60) has received attention because of its high sequence polymorphism and association with host infectivity of isolates and protection against reinfection. However, studies of GP60 function have been hampered by its heavy O-linked glycosylation. Here, we used advanced genetic tools to investigate the processing, fate, and function of GP60. Endogenous gene tagging showed that the GP60 cleavage products, GP40 and GP15, are both highly expressed on the surface of sporozoites, merozoites and male gametes. During …
Frequent Chd1 Deletions In Prostate Cancers Of African American Men Is Associated With Rapid Disease Progression, Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A Sesterhenn, Joel T Moncur, Gregory T Chesnut, Gyorgy Petrovics, Gregory T Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D D'Andrea, Istvan Csabai, Shiv Srivastava, Matthew L Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Frequent Chd1 Deletions In Prostate Cancers Of African American Men Is Associated With Rapid Disease Progression, Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Zsofia Sztupinszki, Denise Young, Darryl Nousome, Claire Kuo, Jiji Jiang, Yongmei Chen, Reinhard Ebner, Isabell A Sesterhenn, Joel T Moncur, Gregory T Chesnut, Gyorgy Petrovics, Gregory T Klus, Gabor Valcz, Pier Vitale Nuzzo, Dezso Ribli, Judit Börcsök, Aurel Prosz, Marcin Krzystanek, Thomas Ried, David Szuts, Kinza Rizwan, Salma Kaochar, Shailja Pathania, Alan D D'Andrea, Istvan Csabai, Shiv Srivastava, Matthew L Freedman, Albert Dobi, Sandor Spisak, Zoltan Szallasi
Faculty, Staff and Students Publications
We analyzed genomic data from the prostate cancer of African- and European American men to identify differences contributing to racial disparity of outcome. We also performed FISH-based studies of Chromodomain helicase DNA-binding protein 1 (CHD1) loss on prostate cancer tissue microarrays. We created CHD1-deficient prostate cancer cell lines for genomic, drug sensitivity and functional homologous recombination (HR) activity analysis. Subclonal deletion of CHD1 was nearly three times as frequent in prostate tumors of African American than in European American men and it associates with rapid disease progression. CHD1 deletion was not associated with HR deficiency associated mutational signatures or HR …
Exploring The Complexity Of Systemic Sclerosis Etiology By Trio Whole Genome Sequencing, Hongzheng Dai, Shamika Ketkar, Taotao Tan, Elizabeth G Atkinson, Lindsay Burrage, Kim C Worley, Brian Christopher, Marka A Lyons, Shervin Assassi, Maureen D Mayes, Brendan Lee
Exploring The Complexity Of Systemic Sclerosis Etiology By Trio Whole Genome Sequencing, Hongzheng Dai, Shamika Ketkar, Taotao Tan, Elizabeth G Atkinson, Lindsay Burrage, Kim C Worley, Brian Christopher, Marka A Lyons, Shervin Assassi, Maureen D Mayes, Brendan Lee
Faculty, Staff and Students Publications
Systemic sclerosis (SSc) is a heterogeneous rare autoimmune fibrosing disorder affecting connective tissue. The etiology of systemic sclerosis is largely unknown and many genes have been suggested as susceptibility loci of modest impact by genome-wide association study (GWAS). Multiple factors can contribute to the pathological process of the disease, which makes it more difficult to identify possible disease-causing genetic alterations. In this study, we have applied whole genome sequencing (WGS) in 101 indexed family trios, supplemented with transcriptome sequencing on cultured fibroblast cells of four patients and five family controls where available. Single nucleotide variants (SNVs) and copy number variants …
Exploring Social Networks: An Analysis Of Intra-Organizational Networks, Ximeng Chen, Yiding Cao, Jiachen Liu, Danushka Bandara, Hiroki Sayama
Exploring Social Networks: An Analysis Of Intra-Organizational Networks, Ximeng Chen, Yiding Cao, Jiachen Liu, Danushka Bandara, Hiroki Sayama
Northeast Journal of Complex Systems (NEJCS)
This research investigates intra-organizational social networks by employing network science methods, aiming to provide actionable insights for both managers and employees. Using datasets from the Colorado Index of Complex Networks (ICON), this study examines four intra-organizational networks from a consulting firm and a research team, focusing on advice requests and skill awareness. The analysis includes network topology, degree distribution, community detection, correlation between communities and node attributes, maximal clique detection, and multilayer network analysis. The findings reveal that intra-organizational networks are intricate and significantly impact organizational efficiency and individual career development. Key insights include the importance of mid-level employees in …
Volume 54-1 Complete Issue, Steven M. Schnell
Volume 54-1 Complete Issue, Steven M. Schnell
The Geographical Bulletin
Volume 54-1 Complete Issue
Using Music To Learn Geomorphology: An Undergraduate Experience, Casey D. Allen, Tyler J. Thompson, Matthew T. Hansen
Using Music To Learn Geomorphology: An Undergraduate Experience, Casey D. Allen, Tyler J. Thompson, Matthew T. Hansen
The Geographical Bulletin
As an alternative to traditional upper-level physical geography pedagogy (labs, quizzes, tests, papers, and occasional field exercises), this article outlines and analyzes a 10-week large-group research endeavor conceived and executed by undergraduates where they explored aspects of project construction, methods, analyses, and group dynamics. These experiences are then critiqued from both instructor- and student-based perspectives. We suggest that pedagogies linking physical geography and traditional humanities disciplines should not be overlooked, especially in physical geography-based courses, as they can expose students to high-level thinking skills such as: not limiting research projects to quantitative observations in a natural setting; implementing a student-friendly …
Nonpoint Source Pollution Risk Mapping For Alabama’S Big Creek Lake, Marco Allain, Jason Jones
Nonpoint Source Pollution Risk Mapping For Alabama’S Big Creek Lake, Marco Allain, Jason Jones
The Geographical Bulletin
Big Creek Lake is the primary water supply for Mobile, Alabama. Management of the watershed is important because nonpoint source (NPS) pollution can introduce contaminants into the lake. After the Mobile Area Water and Sewer System (MAWSS) expressed a need for a land suitability assessment to aid in mitigating NPS pollution in the watershed, we worked to assist them in mapping potential sources of NPS pollution there. First, we created a system for rating the relative contributions of various land cover and soil types to NPS pollution in the watershed. Then, we utilized land use/land cover information generated from ASTER …
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.
Full Issue, Bulletin Of The Texas Ornithological Society
Full Issue, Bulletin Of The Texas Ornithological Society
Bulletin of the Texas Ornithological Society
No abstract provided.