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Articles 6691 - 6720 of 43964
Full-Text Articles in Entire DC Network
The Beacon, September 20, 2024, Beacon Staff
The Beacon, September 20, 2024, Beacon Staff
The Beacon, 2024-2025
Welcoming the Williams to NW; The ins and outs of EMTs on campus; Students gather for Spanish Chapel; An honest review of "Beetlejuice" movie; Keshi conveys emotion in music; "Pork 'N' Bands" - a fun night for all; Taiwan study abroad experience in summer 2025; The Williams enjoy the beauty of Sioux County; How to stand out without burn out; Being a student and EMT; It's time to talk about Minecraft; Breakup over breakfast; Raider golf is dedicated to placing first; Athletes of the week challenge records; Raider cross country aiming to go the extra mile; Bridge Center hosts a …
Ai-Based Assistive Technologies & People With Disabilities: Privacy At Risk, Jasmine Madaan
Ai-Based Assistive Technologies & People With Disabilities: Privacy At Risk, Jasmine Madaan
LLM Theses
This thesis follows three research questions. First, it explores the potential privacy risks that people with disabilities (PWDs) face in the face of incorporation of artificial intelligence (AI) in assistive technologies (ATs). It then investigates reasons that exacerbate PWDs’ vulnerability to such potential privacy risks. Since legal literature in the context of AI-based ATs is limited, this thesis adopts a combination of multidisciplinary and traditional legal doctrinal research by studying legal literature and empirical research in other disciplines. Lastly, the thesis reviews the current Canadian data protection legal framework to examine if there is any provision specifically addressing PWDs or …
Using The Gerontological Imagination To Explore Suicide Among Older Adults: An Interdisciplinary Perspective For Professional Counselors, Mary Chase Mize, Afroze Shaikh
Using The Gerontological Imagination To Explore Suicide Among Older Adults: An Interdisciplinary Perspective For Professional Counselors, Mary Chase Mize, Afroze Shaikh
Adultspan Journal
Gerontology, the study of aging and older adulthood, is a vast field consisting of many intersecting disciplines, such as medicine, nutrition, public policy, psychology, social work, and professional counseling. As the older adult population rapidly increases, so too will the prevalence of mental health concerns among this population, including risk for suicide. Older adults presently comprise 16.5% of the U.S. population, yet account for 19.3% of all deaths by suicide (Drapeau & McIntosh, 2020). Professional counselors are newly eligible Medicare providers and can close gaps in healthcare access for older adults who rely on Medicare to receive mental health services, …
Between Governance And Markets: An Assessment Of Environmental Boundary Organizations, Andy Tuholski
Between Governance And Markets: An Assessment Of Environmental Boundary Organizations, Andy Tuholski
Midwest Social Sciences Journal
This article considers the genesis, characteristics, and dynamics of boundary organizations as they apply specifically to environmental boundary objects, that is, pieces of science on which policy is reliant. Boundary organizations have been widely discussed since the 1990s but are undertheorized in terms of political concepts; this paper approaches environmental boundary organizations as essentially liberal vehicles of power using Lukes’ definition, in which the liberal dimension of power is divided into (a) eliciting and (b) meeting wants of stakeholders equitably. Environmental boundary organizations are compared and contrasted with single-perspective organizations (that is, organizations beholden to either government or industry) and …
Use Of Pulsed Electric Fields And Hydrogen Peroxide For Pre And Postharvest Strategies To Reduce Microbial Loads On Fresh Produce, Zachary Rosenzweig
Use Of Pulsed Electric Fields And Hydrogen Peroxide For Pre And Postharvest Strategies To Reduce Microbial Loads On Fresh Produce, Zachary Rosenzweig
Theses and Dissertations
Several issues exist within the agricultural industry surrounding failure to prevent pathogen transfer to plants preharvest and failure to decontaminate foods postharvest. Fresh produce, like leafy greens, pose a large threat to public safety if contaminated because they are minimally processed and often eaten raw. Numerous outbreaks have been linked to fresh produce in recent decades, with irrigation water emerging as a potential source. These outbreaks have severe economic repercussions and can contribute to millions of hospitalizations and deaths each year, worldwide. This thesis focuses on the usage of pulsed electric fields (PEF) and hydrogen peroxide (H2O2) as a means …
Comparing A Narrative And Didactic Approach To An Invasive Species Education Video, Tim Campbell, Bret Shaw, Amulya Rao, Jenna Klink, Feiran Chen
Comparing A Narrative And Didactic Approach To An Invasive Species Education Video, Tim Campbell, Bret Shaw, Amulya Rao, Jenna Klink, Feiran Chen
Journal of Extension
Video is a common tool for engaging audiences in Extension topics, yet evaluation of the different video production approaches is lacking. We compared learning and emotional outcomes after boaters in the Great Lakes watched either a narrative or didactic video focused on how to prevent the spread of an aquatic invasive species. There were differences in how each approach affected viewers, indicating that there can be utility in both approaches to video production. Extension staff that are creating videos should have these outcomes in mind to promote desired behaviors.
Dissecting The Genetic Architecture Of Sunflower Disc Diameter Using Genome-Wide Association Study, Yavuz Delen, Ravi V. Mural, Semra Palali-Delen, Gen Xu, James C. Schnable, Ismail M. Dweikat, Jinliang Yang
Dissecting The Genetic Architecture Of Sunflower Disc Diameter Using Genome-Wide Association Study, Yavuz Delen, Ravi V. Mural, Semra Palali-Delen, Gen Xu, James C. Schnable, Ismail M. Dweikat, Jinliang Yang
Department of Agronomy and Horticulture: Faculty Publications
Sunflower (Helianthus annuus L.) plays an essential role in meeting the demand for edible oil worldwide. The yield of sunflower seeds encompasses several component traits, including the disc diameter. Over three consecutive years, 2019, 2020, and 2022, we assessed phenotypic variation in disc diameter across a diverse set of sunflower accessions (N = 342) in replicated field trials. Upon aggregating the phenotypic data from multiple years, we estimated the broad sense heritability (H2) of the disc diameter trait to be 0.88. A subset of N = 274 accessions was genotyped by using the tunable genotyping-by-sequencing (tGBS) method, …
Ten Measures To Jointly Explore Shenzhen Model Of Synthetic Biology Development, Xian-En Zhang
Ten Measures To Jointly Explore Shenzhen Model Of Synthetic Biology Development, Xian-En Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
The iteration of biotechnology and the transformative development of biomanufacturing driven by synthetic biology are drawing the blueprint for the future bioeconomy. Around this strategic goal, in the past 10 years, Shenzhen has collaborated with relevant national departments and has taken a series of measures to initially create a sound ecological and innovative chain for synthetic biology and bioindustry. This study summarizes these 10 measures into three major categories: the construction of new R&D institutions and innovation bases, the implementation of technology transformation carriers and synthetic biology industry park, and the measures to encourage students’ innovative spirit. The successful implementation …
Characteristics, Protection, And Utilization Of Marine Ecosystems With Chinese Characteristics, Xin Liu, Si Zhang
Characteristics, Protection, And Utilization Of Marine Ecosystems With Chinese Characteristics, Xin Liu, Si Zhang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Chinese President Xi Jinping proposed the concept of “Martime Community with a Shared Future”. The ocean circulation, the mid-oceanic ridge, and the thermal lava flows constitute the dynamical systems of the maritime community, while the ocean circulation and the material and energy cycles are essential to the global ocean’s connectivity, the mid-oceanic ridge and its thermal lava flows underlie global submarine connectivity, and the marine circulation system, together with the marginal sea submarine system, supports the highly complex biological habitats in the China Sea. Coral island reefs and cold seeps constitute the most characteristic marine ecosystems in China. Conducting research, …
Development Of Brain-Inspired Intelligence Industry In Guangdong-Hong Kong-Macao Greater Bay Area, Xu Zhang, Meihua Ruan
Development Of Brain-Inspired Intelligence Industry In Guangdong-Hong Kong-Macao Greater Bay Area, Xu Zhang, Meihua Ruan
Bulletin of Chinese Academy of Sciences (Chinese Version)
As an emerging frontier field of brain science, the brain-inspired intelligence has been developed rapidly during recent years, leading to the preliminary formation of the brain-inspired intelligence industry, which belongs to the strategic high-end manufacturing industry and has broad development prospects in the era of intelligence. In the future, there will be a huge demand for the brain-inspired intelligence technology and its industry in various fields in China. The Guangdong-Hong Kong-Macao Greater Bay Area is actively planning the research and development of the brain-inspired intelligence technologies and cultivating the related industries by implementing major research programs and establishing new professional …
2024 Issue 9 Content
Bulletin of Chinese Academy of Sciences (Chinese Version)
No abstract provided.
Future Development Strategy And Action Plan For World Network Of Biosphere Reserves, Yu Wei, Xiaoli Shen, Yueyu Zou, Keping Ma
Future Development Strategy And Action Plan For World Network Of Biosphere Reserves, Yu Wei, Xiaoli Shen, Yueyu Zou, Keping Ma
Bulletin of Chinese Academy of Sciences (Chinese Version)
Global environmental governance is currently encountering serious challenges. The lack of integration between biodiversity conservation and Sustainable Development Goals (SDGs) has imposed significant stress on the Earth system. Ecologically significant regions, particularly those with limited resources, are confronted with issues such as weak governance structures and restricted developmental opportunities. As the core platform of the Man and the Biosphere Programme (MAB), the World Network of Biosphere Reserves (WNBR) serves as a global model for reconciling conservation with sustainable development. Nevertheless, it continues to face major obstacles, including insufficient alignment with international frameworks, inadequate financial and human resource allocation, limited coordination …
Contribution Of Biosphere Reserves To Global Biodiversity Conservation And Climate Change, Zhiyun Ouyang, Yunong Yao, Jun Tang, Weihua Xu, Xiaosong Li, Li Zhu, Lei Cao, Mingli Lin, Yueyu Zou
Contribution Of Biosphere Reserves To Global Biodiversity Conservation And Climate Change, Zhiyun Ouyang, Yunong Yao, Jun Tang, Weihua Xu, Xiaosong Li, Li Zhu, Lei Cao, Mingli Lin, Yueyu Zou
Bulletin of Chinese Academy of Sciences (Chinese Version)
Biosphere Reserves are areas recognized by UNESCO that represent key terrestrial, coastal, and marine ecosystems. These areas are strictly protected and designed to fulfill three primary functions: conserving biodiversity, promoting sustainable development, and supporting scientific research and education. As of now, 759 biosphere reserves have been established in 136 countries and regions worldwide, supporting the livelihoods of approximately 236 million people. The total area of biosphere reserves covers 7.67 million km2, accounting for 4.10% of global terrestrial area, 5.08% of freshwater surface, and 0.21% of marine areas. The reserves encompass diverse ecosystems, including 2.22 million km2 of forests, 2.24 million …
Governing Human-Nature Harmony In Protected Area Communities: Global Lessons From Unesco’S Mab Network And Evidence From China’S Biosphere Reserves, Baorong Huang, Xuetian Hu, Ling Tang, Qingyu Lu
Governing Human-Nature Harmony In Protected Area Communities: Global Lessons From Unesco’S Mab Network And Evidence From China’S Biosphere Reserves, Baorong Huang, Xuetian Hu, Ling Tang, Qingyu Lu
Bulletin of Chinese Academy of Sciences (Chinese Version)
Building human-nature harmonious communities is foundational to effective protected-area governance. Drawing on fifty years of global practice under UNESCO’s Man and the Biosphere (MAB) Programme, this study distills four practice-oriented insights: establishing co-management committees to secure the institutional basis; developing ecological branding to add value to ecological products and raise household incomes; cultivating ecological flagships to enhance international reputation and attract investment; and safeguarding cultural diversity to strengthen residents’ sense of belonging and support for management. Case materials are integrated from 34 biosphere reserves in China and an observational indicator framework is constructed and a survey-based assessment is conducted for …
Scientific Research Supports Biosphere’S Conservation —Case Study Of Dinghushan World Biosphere Reserve, Hanping Xia, Juxiu Liu, Xiankai Lu, Hai Ren
Scientific Research Supports Biosphere’S Conservation —Case Study Of Dinghushan World Biosphere Reserve, Hanping Xia, Juxiu Liu, Xiankai Lu, Hai Ren
Bulletin of Chinese Academy of Sciences (Chinese Version)
Based on a brief review of the Dinghushan National Nature Reserve/Dinghushan World Biosphere Reserve, this study comprehensively reviews its scientific research progress in the past 70 years, including three stages: early ecological investigation and biodiversity monitoring; mid-term research on ecosystem structure, function, and dynamics; and recent comprehensive studies. The study also analyzes the role of scientific research in supporting biodiversity conservation, local community sustainable development, and mitigation and adaptation to global climate change in the reserve. Finally, five inspirations and suggestions are proposed to support biosphere conservation through scientific research: (1) research-based conservation has strong vitality; (2) enhancing the level …
Empowering Ecological Monitoring With Science And Technology, Driving Conservation And Development Through Innovation—A Case Study Of Wolong World Biosphere Reserve, Tingmei He, Shufeng Wang, Fan Wu, Yongfeng Wang
Empowering Ecological Monitoring With Science And Technology, Driving Conservation And Development Through Innovation—A Case Study Of Wolong World Biosphere Reserve, Tingmei He, Shufeng Wang, Fan Wu, Yongfeng Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
Ecological monitoring can provide basic data and decision-making support for ecological environment management and policy formulation. The technologies and methods adopted in ecological monitoring by the Wolong National Nature Reserve, located in Sichuan, China, hold extensive representativeness and influence on a global scale. Based on a review of the main monitoring practices of the Wolong World Biosphere Reserve, this paper presents the adoption of different technical paths and collaborative applications in the “sky-Earth-space integrated” monitoring, as well as the practices in promoting the “Five Ones” goals (i.e., one set of data, one platform, one set of algorithms, one cloud, and …
Integrating Protection And Development Issues Through Expansion: A Case Study Of Tianmushan-Qingliangfeng World Biosphere Reserve, Wei Wang
Bulletin of Chinese Academy of Sciences (Chinese Version)
In September 2025, the Fifth UNESCO World Congress of Biosphere Reserves will be held in Hangzhou, China. The delegates will engage in detailed discussions on key issues, including the harmonious coexistence of humans and nature, as well as balanced conservation and development. This congress will also develop a strategic and action plan for the next phase of the world biosphere reserves. The Tianmushan-Qingliangfeng World Biosphere Reserve represents China’s first successful application for world biosphere reserve achieved through an expansion process. Here, this study first elucidates the value and significance of expanding world biosphere reserves. Subsequently, drawing on the practical experience …
Transboundary Conservation Of Biosphere: Case Study From Xishuangbanna World Biosphere Reserve, Lin Wang, Lifan Wang, Xiaoyan Yi, Yun Yang, Ruichang Quan
Transboundary Conservation Of Biosphere: Case Study From Xishuangbanna World Biosphere Reserve, Lin Wang, Lifan Wang, Xiaoyan Yi, Yun Yang, Ruichang Quan
Bulletin of Chinese Academy of Sciences (Chinese Version)
Transboundary conservation, as a pivotal strategy in addressing the global biodiversity crisis, plays a critical role in maintaining ecological connectivity and promoting regional ecological security and sustainable development. Under the initiative of the Xishuangbanna World Biosphere Reserve and with bilateral governmental support from China and Laos, a contiguous transboundary protected area spanning approximately 220 km and encompassing 200 000 hectares was established along their shared border in 2012. This study elucidates the importance of transboundary conservation. Using the Xishuangbanna World Biosphere Reserve as a case study, the joint efforts between China and Laos are examined, and the effectiveness in the …
Developing Integrated Protected Area Communities: Insights From Gaoligongshan Unesco Biosphere Reserve, China, Jianwei Chen, Ling Tang, Ying’An Zhang, Shihai Yu, Hui Yang, Yuanmengran Chu
Developing Integrated Protected Area Communities: Insights From Gaoligongshan Unesco Biosphere Reserve, China, Jianwei Chen, Ling Tang, Ying’An Zhang, Shihai Yu, Hui Yang, Yuanmengran Chu
Bulletin of Chinese Academy of Sciences (Chinese Version)
The integrated protected area community (IPAC) model is a Chinese innovation in protected area governance, emerging from the convergence of national policy support, local government implementation, and community participation. Rather than relying solely on administrative jurisdiction or geographic proximity, IPAC uses protected areas as institutional hubs to align ecological conservation with community development and regional collaboration. Based on the case of the Gaoligongshan UNESCO biosphere reserve, this study examines how policy coordination, stakeholder integration, and ecological value realization are operationalized under the IPAC approach, highlighting an integrated mechanism that combines state-led planning, multi-entity co-governance, and ecological product valorization. The Gaoligongshan …
Tumor-Infiltrating Nerves Functionally Alter Brain Circuits And Modulate Behavior In A Mouse Model Of Head-And-Neck Cancer, Jeffrey Barr, Austin Walz, Anthony C Restaino, Moran Amit, Sarah M Barclay, Elisabeth G Vichaya, William C Spanos, Robert Dantzer, Sebastien Talbot, Paola D Vermeer
Tumor-Infiltrating Nerves Functionally Alter Brain Circuits And Modulate Behavior In A Mouse Model Of Head-And-Neck Cancer, Jeffrey Barr, Austin Walz, Anthony C Restaino, Moran Amit, Sarah M Barclay, Elisabeth G Vichaya, William C Spanos, Robert Dantzer, Sebastien Talbot, Paola D Vermeer
Faculty, Staff and Student Publications
Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer and neuronal tracing, we show that tumor-infiltrating nerves connect to distinct brain areas. The activation of this neuronal circuitry altered behaviors (decreased nest-building, increased latency to eat a cookie, and reduced wheel running). Tumor-infiltrating nociceptor neurons exhibited heightened calcium activity and brain regions receiving these neural projections showed elevated Fos as well as increased calcium responses compared to non-tumor-bearing counterparts. The genetic elimination of nociceptor neurons decreased …
Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 52 – Moscow Dump, Mike Mcanulty
Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 52 – Moscow Dump, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 78 – Original Mine Yard, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Protocol For Establishing And Evaluating A Cancer Cachexia Mouse Model, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yu Ren, Xiuhui Shi, Yang Cai, Alex X Arreola, Yi-Ping Li, Yuqing Zhang, Min Li
Protocol For Establishing And Evaluating A Cancer Cachexia Mouse Model, Zhijun Zhou, Jingxuan Yang, Mingyang Liu, Yu Ren, Xiuhui Shi, Yang Cai, Alex X Arreola, Yi-Ping Li, Yuqing Zhang, Min Li
Faculty, Staff and Student Publications
Cancer cachexia mouse models are needed to recapitulate the clinical features of patients with cachexia. Here, we present a protocol for the establishment and evaluation of cancer cachexia mouse models. We delineate the steps in preparing tumor cells for inoculation and surgical procedures. After the establishment of these mouse models, we describe essential techniques to assess cancer cachexia, including grip strength evaluation, tissue collection, and the calculation of cross-sectional areas of muscle tissue. For complete details on the use and execution of this protocol, please refer to Liu et al.,
The Burden Of Chronic Pain In Transgender And Gender Diverse Populations: Evidence From A Large Us Clinical Database, Tomasz Tabernacki, David Gilbert, Kyle Scarberry, Rachel Pope, Megan Mcnamara
The Burden Of Chronic Pain In Transgender And Gender Diverse Populations: Evidence From A Large Us Clinical Database, Tomasz Tabernacki, David Gilbert, Kyle Scarberry, Rachel Pope, Megan Mcnamara
Student Scholarship
Background: Chronic pain, affecting approximately 20% of the global population, is the leading cause of disability worldwide. Transgender individuals are disproportionately exposed to chronic pain risk factors compared with the cisgender population. This study compares the incidence of chronic pain between transgender and cisgender individuals and examines the impact of gender affirming hormone therapy, anxiety, and depression on chronic pain. Methods: The study analysed medical records data of 56,470 transgender men and 41,882 transgender women in the TrinetX database. Six cohorts were created: transgender women either receiving oestrogen or no intervention, transgender men receiving testosterone or no intervention and cohorts …
Sheared Turbulent Flows And Wake Dynamics Of An Idled Floating Tidal Turbine, Lilian Lieber, Shaun Fraser, Danny Coles, Alex Nimmo Smith
Sheared Turbulent Flows And Wake Dynamics Of An Idled Floating Tidal Turbine, Lilian Lieber, Shaun Fraser, Danny Coles, Alex Nimmo Smith
School of Biological and Marine Sciences
Ocean energy extraction is on the rise. While tides are the most predictable amongst marine renewable resources, turbulent and complex flows still challenge reliable tidal stream energy extraction and there is also uncertainty in how devices change the natural environment. To ensure the long-term integrity of emergent floating tidal turbine technologies, advances in field measurements are required to capture multiscale, real-world flow interactions. Here we use aerial drones and acoustic profiling transects to quantify the site- and scale-dependent complexities of actual turbulent flows around an idled, utility-scale floating tidal turbine (20 m rotor diameter, D). The combined spatial resolution of …
Inorganic Phosphorus Availability And Mobility In A Manufactured Soil, H Kate Schofield, Alan D Tappin, Tim R Pettitt, Gavyn K Rollinson, Mark F Fitzsimons
Inorganic Phosphorus Availability And Mobility In A Manufactured Soil, H Kate Schofield, Alan D Tappin, Tim R Pettitt, Gavyn K Rollinson, Mark F Fitzsimons
School of Geography, Earth and Environmental Sciences
Manufactured soils, created by combining various organic and inorganic waste materials and byproducts, may be tailored to specific applications, providing an alternative to the extraction of natural soils. It is important for them to be capable of supporting plant growth without the need for significant management or fertiliser applications, the over-application of which can have adverse environmental effects. We examined the dynamics of phosphorus (P) transformations within a manufactured soil and the implications for nutrient cycling. A freshly prepared manufactured soil (32.5 % composted green waste, 32.5 % composted bark, 25 % horticultural grit, and 10 % lignite clay) was …
Survival Outcomes After Omission Of Surgery For Ductal Carcinoma In Situ, Elizabeth C Poli, Wenli Dong, Simona F Shaitelman, Nina Tamirisa, Yu Shen, Isabelle Bedrosian
Survival Outcomes After Omission Of Surgery For Ductal Carcinoma In Situ, Elizabeth C Poli, Wenli Dong, Simona F Shaitelman, Nina Tamirisa, Yu Shen, Isabelle Bedrosian
Faculty, Staff and Student Publications
Clinical trials of active surveillance (AS) for Ductal Carcinoma in Situ (DCIS) are underway. We sought to understand the historical management of biologically favorable DCIS and to determine the outcomes of patients who did not have immediate surgery. Using data from the NCDB from 2004 to 2017, the selected cohort included women >40 years of age, with low or intermediate grade and hormone receptor (HR) positive DCIS. AS was defined as either no surgery or surgery >12 months from diagnosis. Women in the AS group were compared to women who had immediate surgery. A Cochran-Armitage test was used to assess …
Butte Priority Soils Operable Unit (Bpsou) Final Insufficiently Reclaimed Sites Field Sampling Plan (Fsp) Bres No. 34e – Eveline Dump East, Mike Mcanulty
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
Germline Mutations In A G Protein Identify Signaling Cross-Talk In T Cells, Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Yamina A Berchiche, D Eric Anderson, Kirk M Druey, Judith N Mandl, Bertrand Isidor, Carlos R Ferreira, Alexandra F Freeman, Sundar Ganesan, Meliha Karsak, Peter J Mustillo, Juliana Teo, Zarazuela Zolkipli-Cunningham, Nicolas Chatron, François Lecoquierre, Andrew J Oler, Jana Pachlopnik Schmid, Douglas B Kuhns, Xuehua Xu, Fabian Hauck, Waleed Al-Herz, Matias Wagner, Paulien A Terhal, Mari Muurinen, Vincent Barlogis, Phillip Cruz, Jeffrey Danielson, Helen Stewart, Petra Loid, Sebastian Rading, Boris Keren, Rolph Pfundt, Kol A Zarember, Katharina Vill, Lorraine Potocki, Kenneth N Olivier, Gaetan Lesca, Laurence Faivre, Melanie Wong, Anne Puel, Janet Chou, Maud Tusseau, Niki M Moutsopoulos, Helen F Matthews, Cas Simons, Ryan J Taft, Ariane Soldatos, Etienne Masle-Farquhar, Stefania Pittaluga, Robert Brink, Danielle L Fink, Heidi H Kong, Juraj Kabat, Woo Sung Kim, Tatjana Bierhals, Kazuyuki Meguro, Amy P Hsu, Jingwen Gu, Jennifer Stoddard, Benito Banos-Pinero, Maria Slack, Giampaolo Trivellin, Benoît Mazel, Maarja Soomann, Samuel Li, Val J Watts, Constantine A Stratakis, Maria F Rodriguez-Quevedo, Ange-Line Bruel, Marita Lipsanen-Nyman, Paul Saultier, Rashmi Jain, Daphne Lehalle, Daniel Torres, Kathleen E Sullivan, Sébastien Barbarot, Axel Neu, Yannis Duffourd, Morgan Similuk, Kirsty Mcwalter, Pierre Blanc, Stéphane Bézieau, Tian Jin, Raif S Geha, Jean-Laurent Casanova, Outi M Makitie, Christian Kubisch, Patrick Edery, John Christodoulou, Ronald N Germain, Christopher C Goodnow, Thomas P Sakmar, Daniel D Billadeau, Sébastien Küry, Vladimir L Katanaev, Yu Zhang, Michael J Lenardo, Helen C Su
Germline Mutations In A G Protein Identify Signaling Cross-Talk In T Cells, Hyoungjun Ham, Huie Jing, Ian T Lamborn, Megan M Kober, Alexey Koval, Yamina A Berchiche, D Eric Anderson, Kirk M Druey, Judith N Mandl, Bertrand Isidor, Carlos R Ferreira, Alexandra F Freeman, Sundar Ganesan, Meliha Karsak, Peter J Mustillo, Juliana Teo, Zarazuela Zolkipli-Cunningham, Nicolas Chatron, François Lecoquierre, Andrew J Oler, Jana Pachlopnik Schmid, Douglas B Kuhns, Xuehua Xu, Fabian Hauck, Waleed Al-Herz, Matias Wagner, Paulien A Terhal, Mari Muurinen, Vincent Barlogis, Phillip Cruz, Jeffrey Danielson, Helen Stewart, Petra Loid, Sebastian Rading, Boris Keren, Rolph Pfundt, Kol A Zarember, Katharina Vill, Lorraine Potocki, Kenneth N Olivier, Gaetan Lesca, Laurence Faivre, Melanie Wong, Anne Puel, Janet Chou, Maud Tusseau, Niki M Moutsopoulos, Helen F Matthews, Cas Simons, Ryan J Taft, Ariane Soldatos, Etienne Masle-Farquhar, Stefania Pittaluga, Robert Brink, Danielle L Fink, Heidi H Kong, Juraj Kabat, Woo Sung Kim, Tatjana Bierhals, Kazuyuki Meguro, Amy P Hsu, Jingwen Gu, Jennifer Stoddard, Benito Banos-Pinero, Maria Slack, Giampaolo Trivellin, Benoît Mazel, Maarja Soomann, Samuel Li, Val J Watts, Constantine A Stratakis, Maria F Rodriguez-Quevedo, Ange-Line Bruel, Marita Lipsanen-Nyman, Paul Saultier, Rashmi Jain, Daphne Lehalle, Daniel Torres, Kathleen E Sullivan, Sébastien Barbarot, Axel Neu, Yannis Duffourd, Morgan Similuk, Kirsty Mcwalter, Pierre Blanc, Stéphane Bézieau, Tian Jin, Raif S Geha, Jean-Laurent Casanova, Outi M Makitie, Christian Kubisch, Patrick Edery, John Christodoulou, Ronald N Germain, Christopher C Goodnow, Thomas P Sakmar, Daniel D Billadeau, Sébastien Küry, Vladimir L Katanaev, Yu Zhang, Michael J Lenardo, Helen C Su
Center for Medical Ethics and Health Policy Staff Publications
Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in GNAI2, which encodes Gαi2, a key component in heterotrimeric G-protein signal transduction usually thought to regulate adenylyl cyclase-mediated cAMP production. Patients with activating Gαi2 mutations had clinical presentations that included impaired immunity. Mutant Gαi2 impaired cell migration and augmented responses to T cell receptor (TCR) stimulation. We found that mutant Gαi2 influenced TCR signaling by sequestering the GTPase-activating protein RASA2, thereby promoting RAS activation and increasing downstream ERK/MAPK and PI3K-AKT S6 signaling to drive cellular growth and proliferation.
Fort Hays State University Tiger Weekly, September 20, 2024, University Relations
Fort Hays State University Tiger Weekly, September 20, 2024, University Relations
Tiger Weekly Newsletters
No abstract provided.