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Dapivirine Levonorgestrel Vaginal Ring: A Multipurpose Prevention Ring For Hiv And Contraceptive Protection, Ipm South Africa

Dapivirine Vaginal Ring (PrEP Ring)

Leveraging our experience developing the monthly dapivirine vaginal ring (DVR or “PrEP ring”), which received a positive opinion from the European Medicines Agency in 2020 for women’s HIV risk reduction, the Population Council is developing a 3-month multipurpose vaginal ring to help women protect against both HIV and unintended pregnancy. This ring is designed to slowly release the antiretroviral (ARV) drug, dapivirine and the contraceptive hormone, levonorgestrel.

Monitoring The Seasonal Presence Of The Blue Shiner, Cyprinella Caerulea, In Little River Canyon National Preserve Using Environmental Dna, Deanna Meadows

Theses

The study of environmental DNA (eDNA) has provided researchers with a more accessible and sensitive way to identify the presence of specific species compared to traditional monitoring methods. eDNA enables species detection by analyzing environmental samples such as water or soil, which contain genetic material shed by organisms in a given area. Research indicates that eDNA techniques have become a valuable method for monitoring threatened and invasive species, proving particularly reliable for detecting aquatic species compared to traditional techniques. Quantitative PCR (qPCR) has been used in numerous eDNA studies, as it provides for greater accuracy than conventional PCR. Cyprinella …

Oxidative Stress Responses In Arabidopsis Thaliana Plants To Uv-B Irradiation, Bolaji Olalere

Theses

The depletion of the stratospheric ozone layer has led to increased levels of harmful UV-B radiation reaching the Earth's surface, posing significant challenges for plant health and development. This study investigates the oxidative stress responses in Arabidopsis thaliana when exposed to UV-B irradiation. Arabidopsis thaliana, a well-established model organism, is particularly sensitive to UV-B, making it ideal for understanding the effects of UV-B-induced oxidative stress. UV-B radiation, a mutagenic component of sunlight, disrupts key metabolic, molecular, and developmental processes, leading to DNA damage, impaired metabolism, and morphological changes. This research aims to explore how UV-B exposure affects the activities of …

Lysosomal Storage Disorder: The Mechanism Of Hurler Syndrome, Ashlyn Ryan, Maria Sebastian

Science University Research Symposium (SURS)

Hurler Syndrome is a rare pediatric neurodegenerative disorder, in which patients experience a multitude of symptoms starting around age 3. These symptoms include skeletal abnormalities, cognitive impairment, stunted growth, heart disease, and many others. The life expectancy of a child diagnosed with Hurler Disease is around 10 to 20 years. Currently, there is no cure for Hurler Syndrome and most treatments are targeted at relieving symptoms. Hurler Syndrome is an inherited lysosomal storage disorder defined by an accumulation of mucopolysaccharides, dermatan sulfate (DS) and heparan sulfate (HS) in tissues. Hurler Syndrome is caused by a mutation in the IDUA gene …

Identifying Neural Correlates Of Balance Impairment In Traumatic Brain Injury Using Partial Least Squares Correlation Analysis, Vikram Shenoy Handiru, Easter Selvan Suviseshamuthu, Soha Saleh, Haiyan Su, Guang Yue, Didier Allexandre

School of Computing Faculty Scholarship and Creative Works

Objective. Balance impairment is one of the most debilitating consequences of traumatic brain injury (TBI). To study the neurophysiological underpinnings of balance impairment, the brain functional connectivity during perturbation tasks can provide new insights. To better characterize the association between the task-relevant functional connectivity and the degree of balance deficits in TBI, the analysis needs to be performed on the data stratified based on the balance impairment. However, such stratification is not straightforward, and it warrants a data-driven approach. Approach. We conducted a study to assess the balance control using a computerized posturography platform in 17 individuals with TBI and …

Fall/Winter 2024, Office Of University Marketing And Communications

Bryant Magazine (1997-2019)(2024-present)

No abstract provided.

The Impact Of Historical Trauma And Political Conflict On Mental Health In Sub-Saharan Africa: A Case Study Of The Drc And Rwanda, Aurore Shima

Switzerland: Global Health and Development Policy

Defined as an individual’s emotional, psychological, and social well-being, mental health is essential for personal recovery and societal stability, especially in post-conflict settings. In regions like Rwanda and the Democratic Republic of Congo (DRC), where communities have endured extreme political violence, the scars of historical trauma remain deep. While various literature exists on the psychological effects of political conflict, few studies have been conducted in Sub-Saharan Africa (SSA), and the impact of historical trauma on mental health outcomes in this region remains sparse. This research explores the psychological effects of historical trauma stemming from political conflict in Rwanda and the …

Proteins Required For Stereocilia Elongation During Mammalian Hair Cell Development Ensure Precise And Steady Heights During Adult Life., Elli I Hartig, Matthew Day, Amandine Jarysta, Basile Tarchini

Faculty Research 2024

Mammalian auditory hair cells (HCs) are not naturally regenerative and must preserve their elaborate structure to ensure lifelong hearing. Stereocilia, the actin-based projections at the HC surface that detect sound vibration, are particularly vulnerable to damage incurred from noise and aging. We show that the tip-localized protein module GPSM2–GNAI required for stereocilia development is also involved in stereocilia maintenance in mature cells. Inactivating Gpsm2 in adult mouse HCs results in low-frequency hearing deficits and stereocilia height reduction proportional to the region reported to turn over actin at the distal tip. Molecular insight into how actin exchange ensures stable height in …

Loss Of Sting Impairs Lactogenic Differentiation., Ramiah R Vickers, Garhett L Wyatt, Lilia Sanchez, Jordyn J Vanportfliet, A Phillip West, Weston W Porter

Faculty Research 2024

Heightened energetic and nutrient demand during lactogenic differentiation of the mammary gland elicits upregulation of various stress responses to support cellular homeostasis. Here, we identify the stimulator of interferon genes (STING) as an immune supporter of the functional development of mouse mammary epithelial cells (MECs). An in vitro model of MEC differentiation revealed that STING is activated in a cGAS-independent manner to produce both type I interferons and proinflammatory cytokines in response to the accumulation of mitochondrial reactive oxygen species. Induction of STING activity was found to be dependent on the breast tumor suppressor gene single-minded 2 (SIM2). Using mouse …

Oncogenic Composite Mutations Can Be Predicted By Co-Mutations And Their Chromosomal Location., Asli Küçükosmanoglu, Carolien L Van Der Borden, Lisanne E A De Boer, Roel G W Verhaak, David Noske, Tom Wurdinger, Teodora Radonic, Bart A Westerman

Faculty Research 2024

Genetic heterogeneity in tumors can show a remarkable selectivity when two or more independent genetic events occur in the same gene. This phenomenon, called composite mutation, points toward a selective pressure, which frequently causes therapy resistance to mutation-specific drugs. Since composite mutations have been described to occur in sub-clonal populations, they are not always captured through biopsy sampling. Here, we provide a proof of concept to predict composite mutations to anticipate which patients might be at risk for sub-clonally driven therapy resistance. We found that composite mutations occur in 5% of cancer patients, mostly affecting the PIK3CA, EGFR, BRAF, and …

Presynaptic Nrxn3 Is Essential For Ribbon-Synapse Maturation In Hair Cells., Alma Jukic, Zhengchang Lei, Elizabeth R Cebul, Katherine Pinter, Yommi Tadesse, Amandine Jarysta, Sandeep David, Natalie Mosqueda, Basile Tarchini, Katie Kindt

Faculty Research 2024

Hair cells of the inner ear and lateral-line system rely on specialized ribbon synapses to transmit sensory information to the central nervous system. The molecules required to assemble these synapses are not fully understood. We show that Nrxn3, a presynaptic adhesion molecule, is crucial for ribbon-synapse maturation in hair cells. In both mouse and zebrafish models, the loss of Nrxn3 results in significantly fewer intact ribbon synapses. We show in zebrafish that, initially, Nrxn3 loss does not alter pre- and postsynapse numbers but, later, synapses fail to pair, leading to postsynapse loss. We also demonstrate that Nrxn3 subtly influences synapse …

Obo Foundry Food Ontology Interconnectivity, Damion Dooley, Liliana Andres-Hernandez, Georgeta Bordea, Leigh Carmody, Duccio Cavalieri, Lauren Chan, Pol Castellano-Escuder, Carl Lachat, Fleur Mougin, Francesco Vitali, Chen Yang, Magalie Weber, Hande Kucuk Mcginty, Matthew Lange

Faculty Research 2024

No abstract provided.

Nsu Kpcom Link - Fall 2024 - Volume 3.3, Nova Southeastern University

NSU Florida Link Newsletter

No abstract provided.

Investigating The Impact Of Nmdar Loss On The Maturation Of Somatostatin Interneurons In Mpfc Of The Mouse Brain, Muhammed Shalan, Zoya Fazal, Gülcan Akgül, Natalia De Marco Garcia

Expo Student Presentations

2024 Fall Expo Online Poster Presentation

• Biological & Life Sciences

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Neurosteroids For The Treatment Of Major Depressive Disorder (Mdd) And Chronic Pain (Paper), Meghan Haan

Honors Capstone Projects

Neurosteroids are endogenous steroids within the brain that act as modulators in neurotransmission. Among their targets are the gamma-aminobutyric acid (GABA) receptors, which are responsible for inhibitory signaling in the brain. The interaction between neurosteroids and GABA receptors is complex, influencing mood regulation and pain perception. Endogenous neurosteroids have been used in conditions such as postpartum depression (PPD), where fluctuation in neurosteroid levels contribute to the onset of depressive systems. Conversely, exogenous neurosteroids, such as brexanolone and zuranolone, have emerged as therapeutic agents for PPD. These compounds act as positive allosteric modulators (PAMs) on GABA receptors, enhancing inhibitory neurotransmission and …

Control Small Weeds In Crops, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

In an integrated weed management program, control of weeds should occur in the fallow, pre-sowing, early post-emergent, and in-pasture phases. Weed control can be achieved through killing weeds (particularly seedlings) with cultivation, herbicides, targeted weed control in wide-row cropping, targeted control of small patches of weeds, and biological control tactics.

Managing Frost Risk, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Frost occurs on clear nights in early spring when the air temperature drops to 2°C or less. Crop damage from frost may occur at any stage of development but is most damaging at or around flowering.

Frost is difficult to manage, and damage will be unavoidable in some seasons. Risk management options proven to reduce frost risk include paddock zoning, crop and variety selection, time of sowing, stubble management and managing inputs. The greatest gains result from in paddock choice/zoning, crop and variety choice, and manipulating the canopy.

Zadoks Growth Scale, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

Zadoks growth scale is a 0-99 scale of development that is recognised internationally for research, advisory work, and farm practice, particularly to time the application of chemicals and fertilisers.

Estimating The Size Of Retained Canola Seed, Department Of Primary Industries And Regional Development, Western Australia

Grains and other field crops factsheets

The size of canola seed (or number of seeds per kilogram) is essential in calculating the seeding rate for the crop. The rate needs to be high enough to get good establishment and protect against pests, diseases, or other seeding issues.

To work out the seeding rate, the seed size or number of seeds per kilogram. This can be easily calculated by farmers who retained seed.

Breast Cancer Screening In Yaoundé, Cameroon: Practices, Awareness, And Perceptions, Tianna Kidd

Cameroon: Development and Social Change

Abstract

Breast cancer is one of the leading causes of death worldwide, yet detection and treatment centers are not always widely available. This research project aims to assess the awareness and perceptions of breast cancer screening practices among women in Cameroon through observing healthcare centers in Yaoundé and conducting interviews with health professionals and a randomized selection of women. The main objective of the study was to identify the resources available for breast cancer screening in Yaoundé and to examine the barriers to breast cancer screening and treatment. Furthermore, the research investigates the available detection devices for breast cancer, particularly …

Characterizing Substituted Imidazolidinetriones As A Novel Class Of Pyruvate Carboxylase Inhibitors, Nicholas O. Schneider

Dissertations (1934 -)

Pyruvate carboxylase (PC) is implicated in a variety of diseases, including type-2 diabetes, cancer, and bacterial/viral infections. However, there are currently no molecular tools capable of precisely manipulating PC activity both in vitro and in vivo. This dissertation describes the identification and characterization of 1,3-disubstituted imidazolidinetriones as a novel class of potent, selective, and permeable allosteric inhibitors of Staphylococcus aureus PC. Based on kinetic, structural, and biophysical data, this class of inhibitors is hypothesized to bind at the noncatalytic “exo binding” site on PC. This exo binding site is reportedly important for catalysis, but it had not previously been considered …

Impact Of Total Participation Techniques On Student Achievement, Ashley Zacharias

Master's Theses & Capstone Projects

The purpose of this action research project was to determine if incorporating total participation techniques into a fifth-grade literacy classroom would increase reading comprehension scores. This researcher was driven to find a teaching strategy that would boost student engagement, participation and academic achievement. It has been proven that student centered learning increases student participation. Evidence has shown increasing student participation and engagement leads to an increase in academic achievement. A quantitative study was used to determine the effectiveness of total participation techniques in a fifth-grade literacy classroom. Comprehension assessment data was collected and analyzed. Data analysis revealed 84% of participants …

Workplace Bullying In Louisiana Academic Libraries: Exploring Worker Status And Demographics, Justin Savage, Andrea Hebert, Catherine Baird

Faculty Publications

Bullying is a phenomenon that exists across cultures, societies, and even species. It can be found everywhere, including the workplace. The present study investigates workplace bullying amongst an approximated census sample of Louisiana academic library workers. Using the Negative Acts Questionnaire—Revised (NAQ-R), the study explores the relationships between experiencing workplace bullying and librarian status, tenure status, years in the profession, age, gender, and race. Although no statistically significant relationships were found between variables, the findings add to a growing body of literature that explores the interrelations of demographic and environmental contexts and bullying experiences.

Cardiovascular Biomarkers Using Deep Learning And Retinal Imaging For The Assessment Of Systemic Disease, Ivan Coronado

Dissertations and Theses (Open Access)

Fundus photography is a radiation-free, non-invasive imaging modality widely employed to assess both ocular and systemic diseases in population-level applications. Traditional methods for extracting cardiovascular biomarkers rely on quantifying vascular features in these images to identify indicators of disease. However, these approaches often depend on manual clinical expertise, which can be costly and time-consuming, making them impractical for large-scale datasets. Deep learning offers a compelling alternative to traditional techniques by enabling the automated processing of extensive datasets with high accuracy. Despite its advantages, deep learning models often function as "black boxes," making it challenging to interpret the features they prioritize …

The Use Of Acupuncture To Manage Dry Mouth Post-Radiotherapy In Head And Neck Cancer Patients, Yen Ming Lin, Claire Forbes-Haley

Peninsula Dental School

At University Hospitals Plymouth NHS Trust (UK), patients with xerostomiaafter head and neck radiotherapy for whom local measures have not beensuccessful are referred to the acupuncture clinic. This has been offered for thelast ten years and preliminary data has shown that it can provide symptomaticrelief to patients. This article documents a service evaluation of 45 patientswho attended the acupuncture clinic from August 2020 to August 2021.Treatment was carried out at three points in each ear as well as a point on thedistal radial aspect of each index finger. Each session lasted for 30 minutesand sessions were carried out weekly for …

A Marketplace (Failure) Of Ideas: Foreign Disinformation Campaigns In An Age Of Generative A.I. And A Proportionality Approach To Falsehoods, Michael K. Park

North Carolina Journal of Law & Technology

No abstract provided.

Res Gestae 2024 Fall Issue, Lindsay Wilcox, Angela Turnbow, Austen Diamond, Lexie Kite, Elizabeth Kronk Warner, Violet Maw, Henry Randolph, Dave Titensor

Law School Historical Documents

The Alumni Magazine for the S.J. Quinney College of Law, University of Utah

2024-2025 Book-In-Common Teaching Guide, Collin College

Book in Common

EDITOR’S INTRODUCTION

As always, the 2024 - 2025 Teaching Guide exemplifies the Collin College Book-in Common Committee’s commitment to the goal of a year-long, college-wide engagement with an important book and its author. This dystopian novel discusses themes of art, culture, survival, relationships, health, and memory. Highlights of this year’s Guide include:

• New for 2024 – 2025
• Fall 2024 Assessment-aligned activities for COAT Core Objective Personal Responsibility
• Review the interactive teaching strategies and access scaffolding activities
• Responses to the text including explorations of the major themes in Station Eleven, reflection prompts, subject assignments, and connections to art, biology, and …

Ua64/2 The Challenge: Magazine For The Center For Gifted Studies (No. 57 Fall 2024), Elizabeth Joyce Editor

Gifted Studies Publications

Magazine created by and about the WKU Center for Gifted Studies.

Legal Considerations For Atmospheric Methane Removal, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

Scientists are beginning to investigate atmospheric methane removal approaches, which would accelerate the conversion of methane to a less radiatively potent form or physically remove methane from the atmosphere and store it elsewhere. Developing and, if appropriate, deploying atmospheric methane removal approaches will require an understanding of relevant legal considerations and governing structures that could impact whether, when, where, and how specific projects take place. This paper examines the treatment of atmospheric methane removal approaches under international and U.S. domestic law. The paper focuses on five atmospheric methane removal approaches that are currently being investigated: (1) atmospheric oxidation enhancement, (2) …