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Articles 5161 - 5190 of 43891
Full-Text Articles in Entire DC Network
Basic Psychological Needs Satisfaction And Well-Being Among Seafarers: An Investigation Of Interaction Effects Through The Lens Of Self-Determination Theory, Nong Vuong Phi, Kung Don Ye, Feng Ming Tsai, Hsiao Chao Hsieh, Shiou-Yu Chen
Basic Psychological Needs Satisfaction And Well-Being Among Seafarers: An Investigation Of Interaction Effects Through The Lens Of Self-Determination Theory, Nong Vuong Phi, Kung Don Ye, Feng Ming Tsai, Hsiao Chao Hsieh, Shiou-Yu Chen
Journal of Marine Science and Technology–Taiwan
Enhancing employee well-being is a primary goal for enterprise sustainable development. Although seafarers represent a major human resource in the maritime industry, the distinctive demands of their profession often compel them to compromise on certain elements in fulfilling their basic psychological needs, thereby contributing to mental health challenges. Recently, COVID-19 and its associated border control measures have prolonged the voyages of seafarers, drawing public attention to the topic of seafarer well-being. In this study, self-determination theory was used to explore the effects of autonomy, competence, and relatedness as fundamental psychological needs on seafarer well-being. After the independent effects of these …
Indigenous Peoples And Environmental Justice: Recognition, Rights, And Representation Of Indigenous Peoples In Bangladesh's Environmental Regulatory Framework, Nasrin Akter
LLM Theses
Using an Environmental Justice theoretical lens, this thesis explores the extent to which the environmental legislative landscape of Bangladesh has ensured environmental justice for Indigenous peoples. In doing so, the thesis concentrates on three main areas: recognition, rights of Indigenous people under the environmental legal framework as well as their representation in the environmental decision making bodies. The research evaluates Bangladesh environmental laws against standards elaborated in the environmental justice literature on each of these three areas. The research employs a combination of legal and policy analysis, as well as a critical analytical approach as part of its methodology. This …
University Of Northern Iowa Fall Faculty Meeting Program, October 7, 2024, University Of Northern Iowa
University Of Northern Iowa Fall Faculty Meeting Program, October 7, 2024, University Of Northern Iowa
University Faculty Documents
The program of the annual Fall Faculty Meeting at the University of Northern Iowa held on October 7, 2024.
The Utah Statesman, October 7, 2024, Utah State University
The Utah Statesman, October 7, 2024, Utah State University
The Utah Statesman
Weekly student newspaper of Utah State University in Logan.
Growth Of Passionflower (Passiflora Incarnata) On A Green Roof Using Commercial Fertilizer Vs. Natural Compost, Siobhan Day, Corinne Parker, Carmyn Harrison, Lauren York
Growth Of Passionflower (Passiflora Incarnata) On A Green Roof Using Commercial Fertilizer Vs. Natural Compost, Siobhan Day, Corinne Parker, Carmyn Harrison, Lauren York
Science University Research Symposium (SURS)
Passionflower (Passiflora incarnata), Tennessee’s state wildflower, is valued for its ecological role as a pollinator plant and its historical significance to the Cherokee, making it an ideal candidate for green roofs that support biodiversity and urban sustainability. This study examined the feasibility of growing passionflower on a green roof and tested whether commercial fertilizer (Miracle-Gro) or natural compost would lead to greater growth compared to no fertilizer. Twelve plants were divided equally into three treatment groups: control, Miracle-Gro, and compost, with growth measurements taken weekly from September to November. Results suggest that passionflowers treated with Miracle-Gro achieved the most growth, …
Top Downloaded Items In Uni Scholarworks, University Of Northern Iowa. Rod Library.
Top Downloaded Items In Uni Scholarworks, University Of Northern Iowa. Rod Library.
Library Documents & Reports (entire collection)
No abstract provided.
In Re: Merck Mumps Vaccine Antitrust Litigation
In Re: Merck Mumps Vaccine Antitrust Litigation
2024 Decisions
USDC for the Eastern District of Pennsylvania
Clinical, Diagnostic, And Metabolic Characteristics Associated With Nephrolithiasis In The Black Women's Health Study, Maria D'Amico, Richard K. Babayan, David S. Wang, Shaun Wason, Yvette C. Cozier
Clinical, Diagnostic, And Metabolic Characteristics Associated With Nephrolithiasis In The Black Women's Health Study, Maria D'Amico, Richard K. Babayan, David S. Wang, Shaun Wason, Yvette C. Cozier
Jefferson Hospital Staff Papers and Presentations
Background/Objectives: Nephrolithiasis (kidney stones) is a frequently occurring urologic condition resulting in significant patient morbidity and healthcare costs. Despite the higher prevalence of metabolic risk factors for nephrolithiasis among Black women, there have been few epidemiologic studies of kidney stones focusing on this group.
Methods: We describe demographic and health characteristics, diagnostics, and metabolic profiles of US Black women with self-reported kidney stones. The women were participants in the Black Women’s Health Study (BWHS), a large prospective cohort of US Black women (median age 38 years) begun in 1995.
Results: Among the 2750 BWHS participants who completed an online supplemental …
Implementation Study Of The Carra Uveitis Consensus Treatment Plans: Feasibility For Clinical Practice And Applicability For Research., Margaret H. Chang, Fatima Barbar-Smiley, Shoghik Akoghlanian, Joanne Drew, Sheila T. Angeles-Han, Megan Quinlan-Waters, John F. Bohnsack, Ashley M. Cooper, Barbara Edelheit, Jennifer Twachtman-Bassett, Melissa A. Lerman, Kabita Nanda, C Egla Rabinovich, Mindy S. Lo, Carra Uveitis Workgroup And The Carra Registry Investigators
Implementation Study Of The Carra Uveitis Consensus Treatment Plans: Feasibility For Clinical Practice And Applicability For Research., Margaret H. Chang, Fatima Barbar-Smiley, Shoghik Akoghlanian, Joanne Drew, Sheila T. Angeles-Han, Megan Quinlan-Waters, John F. Bohnsack, Ashley M. Cooper, Barbara Edelheit, Jennifer Twachtman-Bassett, Melissa A. Lerman, Kabita Nanda, C Egla Rabinovich, Mindy S. Lo, Carra Uveitis Workgroup And The Carra Registry Investigators
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Chronic anterior uveitis (CAU) carries a significant risk for eye complications and vision loss. The Childhood Arthritis and Rheumatology Research Alliance (CARRA) introduced consensus treatment plans (CTPs) to standardize treatment for CAU and facilitate future comparative effectiveness studies. Two CTPs were developed to address: 1) initiation of methotrexate (MTX) in patients with CAU naïve to steroid-sparing therapy, and 2) initiation of a TNF inhibitor (TNFi) in patients with severe uveitis or uveitis refractory to MTX. We evaluated implementation of the uveitis CTPs using existing CARRA Registry infrastructure and assessed feasibility of the CTPs for comparative effectiveness research.
METHODS: This …
Variation In Air Sac Morphology And Postcranial Skeletal Pneumatization Patterns In The African Grey Parrot, Adam B. Lawson, Aracely Martinez, Brandon P. Hedrick, M. Scott Echols, Emma R. Schachner
Variation In Air Sac Morphology And Postcranial Skeletal Pneumatization Patterns In The African Grey Parrot, Adam B. Lawson, Aracely Martinez, Brandon P. Hedrick, M. Scott Echols, Emma R. Schachner
School of Graduate Studies Faculty Publications
The anatomy of the avian lower respiratory system includes a complex interaction between air-filled pulmonary tissues, pulmonary air sacs, and much of the postcranial skeleton. Hypotheses related to the function and phylogenetic provenance of these respiratory structures have been posed based on extensive interspecific descriptions for an array of taxa. By contrast, intraspecific descriptions of anatomical variation for these features are much more limited, particularly for skeletal pneumatization, and are essential to establish a baseline for evaluating interspecific variation. To address this issue, we collected micro-computed tomography (μCT) scans of live and deceased African grey parrots (Psittacus erithacus) to assess …
10.07.2024 Orsp Connect, Liz Williamson
10.07.2024 Orsp Connect, Liz Williamson
ORED Newsletter
Lunch and Learn
Update Employee Directory
NIH Updates RPPR Instruction Guide
Genetically Conditioned Interaction Among Microrna-155, Alpha-Klotho, And Intra-Renal Ras In Male Rats: Link To Ckd Progression, Lisa M. Harrison-Bernard, L. Raij, R. X. Tian, E. A. Jaimes
Genetically Conditioned Interaction Among Microrna-155, Alpha-Klotho, And Intra-Renal Ras In Male Rats: Link To Ckd Progression, Lisa M. Harrison-Bernard, L. Raij, R. X. Tian, E. A. Jaimes
School of Graduate Studies Faculty Publications
Incident chronic kidney disease (CKD) varies in populations with hypertension of similar severity. Proteinuria promotes CKD progression in part due to activation of plasminogen to plasmin in the podocytes, resulting in oxidative stress-mediated injury. Additional mechanisms include deficiency of renal alpha-klotho, that inhibits Wnt/beta-catenin, an up regulator of intra-renal renin angiotensin system (RAS) genes. Alpha-klotho deficiency therefore results in upregulation of the intra-renal RAS via Wnt/beta-catenin. In hypertensive, Dahl salt sensitive (DS) and spontaneously hypertensive rats (SHR), we investigated renal and vascular injury, miR-155, AT1R, alpha-klotho, and TNF-α. Hypertensive high salt DS (DS-HS), but not SHR developed proteinuria, plasminuria, and …
Introduction: Giving Room To Embodied Relationships, Jeremy D. Bendik-Keymer
Introduction: Giving Room To Embodied Relationships, Jeremy D. Bendik-Keymer
Faculty Scholarship
The special issue Z(a)dziwienie ciałem—to Wonder (to Wander) in Corporeal Relationships aims to contribute modestly and imaginatively to the recent wave of work around wonder. In some respects, too, it continues the short seminar “Discussing Wonder” published in Studia Philosophica Wratislaviensia vol. XV, no. 2 (2020). In the ancient Greek philosophical tradition, wonder helped philosophers make sense of the nature of their own inquiries and their striving for knowledge. This is the context in which Plato and Aristotle first discussed wonder (thaumadzein). The concept was reprised in a similar framework when Descartes and Spinoza laid foundations for modern philosophy, and …
Exploring The Perpetuation And Disruption Of Gendered, Racial, And Working Style Stereotypes In U.S. Life Science Textbooks, Austin R. Jenkins, Gina Zaccagnini, Breanya Hogue
Exploring The Perpetuation And Disruption Of Gendered, Racial, And Working Style Stereotypes In U.S. Life Science Textbooks, Austin R. Jenkins, Gina Zaccagnini, Breanya Hogue
Department of Curriculum and Instruction Faculty Publications
Textbooks convey powerful messages to students about who can legitimately participate in science, technology, engineering, and mathematics (STEM). Using culturally relevant pedagogy as the guiding theoretical framework, this study sought to explore the extent to which secondary life science textbooks are culturally relevant in their depiction of gender, race, working style, and range of ability. Critical multicultural content analysis guided this research to explore the ways in these textbooks uphold or disrupt stereotypical notions of STEM professionals. Analysis indicated more images of females compared to males, but perpetuated notions of White, able-bodied scientists working alone. Given these findings, gendered power …
Maritime Autonomy And Liability: Navigating Uncharted Waters, Manal Cheema, Ariel Sarandinaki
Maritime Autonomy And Liability: Navigating Uncharted Waters, Manal Cheema, Ariel Sarandinaki
International Law Studies
For centuries, people have voyaged the seas, structuring international and domestic law around the premise that people crew ships. However, that premise is no longer guaranteed as unmanned systems and vessels begin to embark on the waters. As the international community and U.S. legislators grapple with whether the law of the sea and domestic maritime law must adapt to accommodate the newest seafarers, it becomes evident that they need to be fully prepared to answer questions of liability and responsibility regarding unmanned vessels. This will become especially apparent when unmanned vessels collide with manned or other unmanned vessels. This article …
Rescue Of Scn5a Mis-Splicing Does Not Improve The Structural And Functional Heart Defects Of A Dm1 Heart Mouse Model, Larissa Nitschke, Rong-Chi Hu, Andrew N Miller, Thomas A Cooper
Rescue Of Scn5a Mis-Splicing Does Not Improve The Structural And Functional Heart Defects Of A Dm1 Heart Mouse Model, Larissa Nitschke, Rong-Chi Hu, Andrew N Miller, Thomas A Cooper
Faculty, Staff and Students Publications
Myotonic Dystrophy Type 1 (DM1) is an autosomal dominant multisystemic disorder for which cardiac features, including conduction delays and arrhythmias, are the second leading cause of disease mortality. DM1 is caused by expanded CTG repeats in the 3' untranslated region of the DMPK gene. Transcription of the expanded DMPK allele produces mRNAs containing long tracts of CUG repeats, which sequester the Muscleblind-Like family of RNA binding proteins, leading to their loss-of-function and the dysregulation of alternative splicing. A well-characterized mis-regulated splicing event in the DM1 heart is the increased inclusion of SCN5A exon 6A rather than the mutually exclusive exon …
Chimes: October 7, 2024, Calvin University
Chimes: October 7, 2024, Calvin University
Chimes
CERF: A look at Calvin's best kept sustainability secret by Ian Tjoelker
"Over All This, Put On Love": building effective political dialogue on campus by Graham Kort
The changing face of world Christianity: a Q&A with Dr. Damaris Parsitau by Ethan Meyers
French Film Festival: A Celebration of Culture and Film by Natasha Jayaputra
Big sport milestones for homecoming weekend by Dillion Baumchen
A look at how campus offices are adapting to digitally immersed students by Elisabeth Stevens
Lord of the Sabbath by Ashley Hamons
Exploring Variations In Stem Instructors’ Approaches To Office Hours, Desiree Forsythe, Rebecca M. Green, Jeremy L. Hsu
Exploring Variations In Stem Instructors’ Approaches To Office Hours, Desiree Forsythe, Rebecca M. Green, Jeremy L. Hsu
Biology, Chemistry, and Environmental Sciences Faculty Articles and Research
Office hours are an integral component of science, technology, engineering, and math (STEM) courses at nearly all colleges and universities. Despite their ubiquity as a support mechanism, there has only been limited work examining how instructors approach office hours and what shapes these approaches. Here, we conduct a phenomenographic study to investigate how instructors of STEM courses experience office hours and how these experiences may impact their approaches to promoting and managing office hours. We identified variations in how instructors promoted office hours, the modality of office hours (i.e., when and where office hours were held), and how instructors facilitated …
Dna Methylation Near Mad1l1, Kdm2b, And Socs3 Mediates The Effect Of Socioeconomic Status On Elevated Body Mass Index In African American Adults, Láshauntá Glover, Adam G Lilly, Anne E Justice, Annie Green Howard, Brooke S Staley, Yujie Wang, Helen M Kamens, Kendra Ferrier, Jan Bressler, Laura Loehr, Laura M Raffield, Mario Sims, Kari E North, Lindsay Fernández-Rhodes
Dna Methylation Near Mad1l1, Kdm2b, And Socs3 Mediates The Effect Of Socioeconomic Status On Elevated Body Mass Index In African American Adults, Láshauntá Glover, Adam G Lilly, Anne E Justice, Annie Green Howard, Brooke S Staley, Yujie Wang, Helen M Kamens, Kendra Ferrier, Jan Bressler, Laura Loehr, Laura M Raffield, Mario Sims, Kari E North, Lindsay Fernández-Rhodes
Faculty, Staff and Student Publications
Obesity and poverty disproportionally affect African American persons. Epigenetic mechanisms could partially explain the association between socioeconomic disadvantage and body mass index (BMI). We examined the extent to which epigenetic mechanisms mediate the effect of socioeconomic status (SES) on BMI. Using data from African American adults from the Atherosclerosis Risk in Communities (ARIC) Study (n = 2664, mean age = 57 years), education, income, and occupation were used to create a composite SES score at visit 1 (1987-1989). We conducted two methylation-wide association analyses to identify associations between SES (visit 1), BMI and cytosine-phosphate-guanine (CpG) sites measured at a subsequent …
Digital Assessments For Children And Adolescents With Adhd: A Scoping Review, Franceli L. Cibrian, Elissa M. Monteiro, Kimberley D. Lakes
Digital Assessments For Children And Adolescents With Adhd: A Scoping Review, Franceli L. Cibrian, Elissa M. Monteiro, Kimberley D. Lakes
Engineering Faculty Articles and Research
Introduction: In spite of rapid advances in evidence-based treatments for attention deficit hyperactivity disorder (ADHD), community access to rigorous gold-standard diagnostic assessments has lagged far behind due to barriers such as the costs and limited availability of comprehensive diagnostic evaluations. Digital assessment of attention and behavior has the potential to lead to scalable approaches that could be used to screen large numbers of children and/or increase access to high-quality, scalable diagnostic evaluations, especially if designed using user-centered participatory and ability-based frameworks. Current research on assessment has begun to take a user-centered approach by actively involving participants to ensure the development …
M3t-Lm: A Multi-Modal Multi-Task Learning Model For Jointly Predicting Patient Length Of Stay And Mortality, Junde Chen, Qing Li, Feng Liu, Yuxin Wen
M3t-Lm: A Multi-Modal Multi-Task Learning Model For Jointly Predicting Patient Length Of Stay And Mortality, Junde Chen, Qing Li, Feng Liu, Yuxin Wen
Engineering Faculty Articles and Research
Ensuring accurate predictions of inpatient length of stay (LoS) and mortality rates is essential for enhancing hospital service efficiency, particularly in light of the constraints posed by limited healthcare resources. Integrative analysis of heterogeneous clinic record data from different sources can hold great promise for improving the prognosis and diagnosis level of LoS and mortality. Currently, most existing studies solely focus on single data modality or tend to single-task learning, i.e., training LoS and mortality tasks separately. This limits the utilization of available multi-modal data and prevents the sharing of feature representations that could capture correlations between different tasks, ultimately …
An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, William A Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J Lazar, Khalida Wani, William P Israel, Zhan Zhang, Venkata S Chaluvadi, Robert J Norgard, Ying Liu, Ashley M Fuller, Mai T Dang, Robert E Roses, Giorgos C Karakousis, John T Miura, Douglas L Fraker, T S Karin Eisinger-Mathason, M Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, William A Molina Arocho, Tsun Ki Jerrick To, Samir Devalaraja, Irene S Molina, Jason Shoush, Hesham Mohei, Li Zhai, Md Naushad Akhtar, Veena Kochat, Emre Arslan, Alexander J Lazar, Khalida Wani, William P Israel, Zhan Zhang, Venkata S Chaluvadi, Robert J Norgard, Ying Liu, Ashley M Fuller, Mai T Dang, Robert E Roses, Giorgos C Karakousis, John T Miura, Douglas L Fraker, T S Karin Eisinger-Mathason, M Celeste Simon, Kristy Weber, Kai Tan, Yi Fan, Kunal Rai, Malay Haldar
Faculty, Staff and Student Publications
We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …
Conserved Signaling Modules Regulate Filamentous Growth In Fungi: A Model For Eukaryotic Cell Differentiation, Matthew D Vandermeulen, Michael C Lorenz, Paul J Cullen
Conserved Signaling Modules Regulate Filamentous Growth In Fungi: A Model For Eukaryotic Cell Differentiation, Matthew D Vandermeulen, Michael C Lorenz, Paul J Cullen
Faculty, Staff and Student Publications
Eukaryotic organisms are composed of different cell types with defined shapes and functions. Specific cell types are produced by the process of cell differentiation, which is regulated by signal transduction pathways. Signaling pathways regulate cell differentiation by sensing cues and controlling the expression of target genes whose products generate cell types with specific attributes. In studying how cells differentiate, fungi have proved valuable models because of their ease of genetic manipulation and striking cell morphologies. Many fungal species undergo filamentous growth-a specialized growth pattern where cells produce elongated tube-like projections. Filamentous growth promotes expansion into new environments, including invasion into …
The Effect Of Small Class Size From Kindergarten Through Third Grade On Eighth-Grade Gender Reading Achievement, Christopher Harry
The Effect Of Small Class Size From Kindergarten Through Third Grade On Eighth-Grade Gender Reading Achievement, Christopher Harry
Seton Hall University Dissertations and Theses (ETDs)
This study examined the effect of small class size intervention on student outcomes using reading achievement scores as measured by the Comprehensive Test of Basic Skills (CTBS), a standardized, norm-referenced test, while controlling for independent variables inclusive of students' gender, race, socioeconomic status (SES), and environment. This study included students who participated in a randomized, long-term study, the Tennessee Student Teacher Achievement Ratio (STAR) experiment from 1985 through 1989. The STAR study took place in the Tennessee public school system, encompassing two groups of students: those who received treatment, small class intervention, 657 students, and students who did not, 5,689. …
Genomics Of Natural Populations: Gene Conversion Events Reveal Selected Genes Within The Inversions Of Drosophila Pseudoobscura, Stephen W Schaeffer, Stephen Richards, Zachary L Fuller
Genomics Of Natural Populations: Gene Conversion Events Reveal Selected Genes Within The Inversions Of Drosophila Pseudoobscura, Stephen W Schaeffer, Stephen Richards, Zachary L Fuller
Faculty, Staff and Students Publications
When adaptive phenotypic variation or quantitative trait loci map within an inverted segment of a chromosome, researchers often despair because the suppression of crossing over will prevent the discovery of selective target genes that established the rearrangement. If an inversion polymorphism is old enough, then the accumulation of gene conversion tracts offers the promise that quantitative trait loci or selected loci within inversions can be mapped. The inversion polymorphism of Drosophila pseudoobscura is a model system to show that gene conversion analysis is a useful tool for mapping selected loci within inversions. D. pseudoobscura has over 30 different chromosomal arrangements …
An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, Mai T Dang, Et Al.
An Iron-Rich Subset Of Macrophages Promotes Tumor Growth Through A Bach1-Ednrb Axis, Ian W Folkert, Mai T Dang, Et Al.
2020-Current year OA Pubs
We define a subset of macrophages in the tumor microenvironment characterized by high intracellular iron and enrichment of heme and iron metabolism genes. These iron-rich tumor-associated macrophages (iTAMs) supported angiogenesis and immunosuppression in the tumor microenvironment and were conserved between mice and humans. iTAMs comprise two additional subsets based on gene expression profile and location-perivascular (pviTAM) and stromal (stiTAM). We identified the endothelin receptor type B (Ednrb) as a specific marker of iTAMs and found myeloid-specific deletion of Ednrb to reduce tumor growth and vascular density. Further studies identified the transcription factor Bach1 as a repressor of the iTAM transcriptional …
Association Between Particulate Matter And Copd Among Adults In Alaska, Adeyemi Samuel Alimi
Association Between Particulate Matter And Copd Among Adults In Alaska, Adeyemi Samuel Alimi
Walden Dissertations and Doctoral Studies
Exposure to high levels of fine particulate matter (PM2.5) is emerging as a crucial risk factor for chronic obstructive pulmonary disease (COPD), a deadly lung disease with a significant public health burden. The Fairbanks North Star Borough (FNSB) in Alaska has one of the worst PM2.5 issues in the United States. The PM2.5 issues in the area are associated with increased wood-burning and temperature inversions in the winter and wildfires in the summer. Given these prevailing PM2.5 issues, this quantitative study was conducted using Alaska BRFSS datasets and a chi-square test to compare the COPD prevalence in the FNSB with …
Alzheimer’S Disease Risk Gene Cd2ap Is A Dose-Sensitive Determinant Of Synaptic Structure And Plasticity, Matea Pavešković, Ruth B De-Paula, Shamsideen A Ojelade, Evelyne K Tantry, Mikhail Y Kochukov, Suyang Bao, Surabi Veeraragavan, Alexandra R Garza, Snigdha Srivastava, Si-Yuan Song, Masashi Fujita, Duc M Duong, David A Bennett, Philip L De Jager, Nicholas T Seyfried, Mary E Dickinson, Jason D Heaney, Benjamin R Arenkiel, Joshua M Shulman
Alzheimer’S Disease Risk Gene Cd2ap Is A Dose-Sensitive Determinant Of Synaptic Structure And Plasticity, Matea Pavešković, Ruth B De-Paula, Shamsideen A Ojelade, Evelyne K Tantry, Mikhail Y Kochukov, Suyang Bao, Surabi Veeraragavan, Alexandra R Garza, Snigdha Srivastava, Si-Yuan Song, Masashi Fujita, Duc M Duong, David A Bennett, Philip L De Jager, Nicholas T Seyfried, Mary E Dickinson, Jason D Heaney, Benjamin R Arenkiel, Joshua M Shulman
Duncan NRI Faculty and Staff Publications
CD2-Associated protein (CD2AP) is a candidate susceptibility gene for Alzheimer's disease, but its role in the mammalian central nervous system remains largely unknown. We show that CD2AP protein is broadly expressed in the adult mouse brain, including within cortical and hippocampal neurons, where it is detected at pre-synaptic terminals. Deletion of Cd2ap altered dendritic branching and spine density, and impaired ubiquitin-proteasome system activity. Moreover, in mice harboring either one or two copies of a germline Cd2ap null allele, we noted increased paired-pulse facilitation at hippocampal Schaffer-collateral synapses, consistent with a haploinsufficient requirement for pre-synaptic release. Whereas conditional Cd2ap knockout in …
Trβ Activation Confers At2-To-At1 Cell Differentiation And Anti-Fibrosis During Lung Repair Via Klf2 And Cebpa, Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu
Trβ Activation Confers At2-To-At1 Cell Differentiation And Anti-Fibrosis During Lung Repair Via Klf2 And Cebpa, Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Ivan O Rosas, Guoying Yu
Faculty, Staff and Students Publications
Aberrant repair underlies the pathogenesis of pulmonary fibrosis while effective strategies to convert fibrosis to normal regeneration are scarce. Here, we found that thyroid hormone is decreased in multiple models of lung injury but is essential for lung regeneration. Moreover, thyroid hormone receptor α (TRα) promotes cell proliferation, while TRβ fuels cell maturation in lung regeneration. Using a specific TRβ agonist, sobetirome, we demonstrate that the anti-fibrotic effects of thyroid hormone mainly rely on TRβ in mice. Cellularly, TRβ activation enhances alveolar type-2 (AT2) cell differentiation into AT1 cell and constrains AT2 cell hyperplasia. Molecularly, TRβ activation directly regulates the …
A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees
A Geospatial Approach To Landscape Gaze Using Social Media To Evaluate How People Value Landscapes In An Urban Context, Riley Bibaud, Eva Mcgrath, Zoe Sydenham, Richard Yarwood, Tom Mullier, Siân Rees
School of Biological and Marine Sciences
Urban park management generally prioritises green spaces and activities within park boundaries, rather than landscape interactions. Understanding how people experience and connect with broader landscapes is essential for improving societal environmental, economic and wellbeing outcomes. A geospatial and discourse analysis of three urban parks was conducted in Plymouth, UK. The predominant landscape gaze at each park revealed strong social ties to blue spaces–namely the coast and sea–indicating an interconnectedness between parks and coastal spaces beyond park boundaries. Textual analysis emphasised the beauty of nature, the expanse of the ocean, and the health and wellbeing benefits of blue and green spaces. …