Digital Commons Network^™

Development Of Tio2/Nh2-Mil-125 Nanocomposite For The Removal Of Ciprofloxacin Under Induced Solar Irradiation, Bilkis Mojisola Ajiwokewu

Theses

This research focuses on the development and application of Metal-Organic Frameworks (MOFs)-based nanocomposites for the photocatalytic removal of pharmaceutical contaminants, with a specific emphasis on ciprofloxacin (CIP). The photocatalytic degradation of CIP was investigated using as-synthesized photocatalysts of TiO₂ nanowires (TiO₂NWs), bare MOF of NH₂-MIL-125, TiO₂NW/NH₂-MIL-125 composite, and Lanthanum (La)-doped composite. Intriguingly, the TiO₂NW/NH₂-MIL-125 composite exhibited the highest efficiency, achieving a photodegradation rate of 0.0111 min-1, surpassing the independent performances of bare MOF of NH₂-MIL-125 and TiO₂NW. The observed efficiency was attributed to …

Speech Regulation And Tobacco Harm Reduction, Jonathan H. Adler, Jacob James Rich

Faculty Publications

Part I of this essay describes what is currently understood about the relative health risks of ENDS [electronic nicotine delivery systems] and other vaping products, particularly as compared to combustible cigarettes.

Part II of this essay describes the current regulatory regime governing tobacco products and how this regime has been applied to ENDS and other vaping products.

Part III of this essay explains how the FDA’s regulatory regime hampers the ability of ENDS manufacturers to inform consumers about the relative risks of their products and the potential use of ENDS as smoking cessation aids.

Part IV explains why this regulation …

Tarnished Gold: The Endangered Species Act At 50, Jonathan H. Adler

Faculty Publications

This Article aims to take stock of the [Endangered Species Act] ESA’s success and failures during its first fifty years, particularly with regard to the conservation of species habitat on private land. While the ESA authorizes powerful regulatory tools for species conservation, there are serious questions as to whether such tools are the most effective means of conserving species and the habitats on which they rely. Given that most species rely upon private land for their survival, the ESA’s ability to foster private land conservation will affect the law’s overall success.

This abstract has been taken from the author's introduction.

Mechanism Of Action Of Kl-50, A Candidate Imidazotetrazine For The Treatment Of Drug-Resistant Brain Cancers, Eric D. Huseman, Anna Lo, Olga Fedorova, James L. Elia, Susan E. Gueble, Kingson Lin, Ranjini K. Sundaram, Jooneseok Oh, Jinchan Liu, Fabian Menges, Matthew G. Rees, Melissa M. Ronan, Jennifer A. Roth, Victor S. Batista, Jason M. Crawford, Anna M. Pyle, Ranjit S. Bindra, Seth B. Herzon

Chemistry Faculty Research and Publications

Aberrant DNA repair is a hallmark of cancer, and many tumors display reduced DNA repair capacities that sensitize them to genotoxins. Here, we demonstrate that the differential DNA repair capacities of healthy and transformed tissue may be exploited to obtain highly selective chemotherapies. We show that the novel N3-(2-fluoroethyl)imidazotetrazine “KL-50” is a selective toxin toward tumors that lack the DNA repair protein O⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O⁶-alkylguanine lesions. We establish that KL-50 generates DNA interstrand cross-links (ICLs) by a multistep process comprising DNA alkylation to generate an O⁶-(2-fluoroethyl)guanine (O⁶FEtG) …

Terra-Lsd1 Phase Separation Promotes R-Loop Formation For Telomere Maintenance In Alt Cancer Cells, Nicholas J. Reiter

Chemistry Faculty Research and Publications

The telomere repeat-containing RNA (TERRA) forms R-loops to promote homology-directed DNA synthesis in the alternative lengthening of telomere (ALT) pathway. Here we report that TERRA contributes to ALT via interacting with the lysine-specific demethylase 1A (LSD1 or KDM1A). We show that LSD1 localizes to ALT telomeres in a TERRA dependent manner and LSD1 function in ALT is largely independent of its demethylase activity. Instead, LSD1 promotes TERRA recruitment to ALT telomeres via RNA binding. In addition, LSD1 and TERRA undergo phase separation, driven by interactions between the RNA binding properties of LSD1 and the G-quadruplex structure of TERRA. Importantly, the …

Targeting Of Oncogenic Aaa-Atpase Trip13 Reduces Progression Of Pancreatic Ductal Adenocarcinoma, Farrukh Afaq, Sumit Agarwal, Prachi Bajpai, Sameer Al Diffalha, Hyung-Gyoon Kim, Shajan Peter, Moh'd Khushman, Subhash Chauhan, Priyabrata Mukherjee, Sooryanarayana Varambally, Upender Manne

School of Medicine Publications

Thyroid hormone receptor-interacting protein 13 (TRIP13) is involved in cancer progression, but its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. Thus, we assessed the expression, functional role, and mechanism of action of TRIP13 in PDAC. We further examined the efficacy of TRIP13 inhibitor, DCZ0415, alone or in combination with gemcitabine on malignant phenotypes, tumor progression, and immune response. We found that TRIP13 was overexpressed in human PDACs relative to corresponding normal pancreatic tissues. TRIP13 knockdown or treatment of PDAC cells with DCZ0415 reduced proliferation and colony formation, and induced G2/M cell cycle arrest and apoptosis. Additionally, TRIP13 knockdown …

Exploring The Association Between Structural Racism And Mental Health: Geospatial And Machine Learning Analysis, Fahimeh Mohebbi, Amir Masoud Forati, Lucas Torres, Terri A. Deroon-Cassini, Jennifer Harris, Carissa W. Tomas, John R. Mantsch, Rina Ghose

Psychology Faculty Research and Publications

Background:

Structural racism produces mental health disparities. While studies have examined the impact of individual factors such as poverty and education, the collective contribution of these elements, as manifestations of structural racism, has been less explored. Milwaukee County, Wisconsin, with its racial and socioeconomic diversity, provides a unique context for this multifactorial investigation.

Objective:

This research aimed to delineate the association between structural racism and mental health disparities in Milwaukee County, using a combination of geospatial and deep learning techniques. We used secondary data sets where all data were aggregated and anonymized before being released by federal agencies.

Methods:

We …

Intercropping Maize–Faba Bean Reduced Yield And Economiclosses Caused By Busseola Fusca (Fuller) In Semiarid Area, Tesfay Gidey, Daniel Hagos Berhe, Emiru Birhane, Haftu Abrha, Yirga Guf

All Grantees Publications

Climate change is impacting the sustainability of indigenous tree species. However, the impacts of climate change on African olivetree (Olea europaea subspecies Cuspidata) are less-explored. Tis study, conducted in Tigray, northern Ethiopia, aims to de-termine the impacts of climate change on the current and future distributions of the species. A total of 225 presence points andabundance of O. europaea within 20 m × 20 m plots at each location were collected. Additional input variables, such as the 19bioclimatic variables, 3 topographic variables, and Pedologic data, were used. Maxent software was employed to predict thedistribution of the species under current and …

First Report Of Penicillium Sclerotigenum Causing Post-Harvest Rotof Yam In Côte D’Ivoire, A Kamara, B Camara, A D. Armitage, O Ogunsanya, V Gouannou, D Koné

All Grantees Publications

Yam (Dioscorea spp.) is the third most produced non-cereal crop withglobal production of 72 million tonnes per year and is cultivated acrossWest Africa. With a production of over 7 million tonnes, Côte d’Ivoireis the world’s third largest producer and yam is the country’s main non-cereal food crop (Scott et al., 2020). However, the storage life of yamsis greatly reduced by post-harvest rots and previous studies revealedthat a range of fungi were responsible, including Aspergillus Botryodiplo-dia, Colletotrichum, Mucor and Penicillium species (Assiri Kouamé et al.,2017).

Insights On The Microbiology Of Ethiopian Fermented Milkproducts: A Review, Tiruha H. Karssa, Jamal B. Kussaga, Teresa Semedo-Lemsaddek, Jovin K. Mugula

All Grantees Publications

Fermented milk products play a vital role in the diets of Ethiopians. They are producedfrom either spontaneous fermentation or back- slopping methods at the householdlevel, in which lactic acid bacteria (LAB) and yeasts predominate. As a result, the pro-cessing steps are not standardized and overall safety is still of public health relevance.Therefore, quality and safety improvement, standardization of traditional manufac-turing practices, and commercialization of products to a wider market are important.Hence, this systematic review aimed to provide a comprehensive overview of themicrobiology of traditional Ethiopian fermented milk products, including ergo (spon-taneously fermented whole milk), dhanaan (fermented camel milk), ititu (concentratedsour …

Performance Assessment Of Biomass-Derived Urea-Furfuraldehyde Resins As Oilfield Scale Inhibitors, Cynthia Onyekachi Victor-Oji, Una Dominica, Onyewuchi Akaranta

All Grantees Publications

Oilfield-scale formation is a persistent challenge in the oil industry. While numerous scale inhibitors have been in use for decades, there is a significant research gap in discovering renewable, cost-effective, ecologically friendly, and efficient inhibitors. This study sets out to fill this gap by investigating the potential of scale inhibitors (SIs) made from bio-resin derivatives of red onion skin; ROF and ROFU, in reducing CaCO3 and CaSO4 scales. The scale inhibition performance of ROF and ROFU was rigorously evaluated using the NACE standard static bottle test method. The data revealed that increasing scale-inhibitor contact time, concentration, and temperature enhances inhibitor …

Rwandan Farmers’ Perceptions Of The Acoustic Environment And The Potential For Acoustic Monitoring, Destiny Kwabla Amenyedzi, Micheline Kazeneza, Frederic Nzanywayingoma, Philibert Nsengiyumva

All Grantees Publications

Monitoring the farm acoustic environment can provide important information about processes affecting crop production. This paper assesses farmers’ knowledge and attitudes toward acoustic technology for farm monitoring in Rwanda. Stratified random sampling was used to select 430 farmers from 3 sectors. Demographic, farm, and technical knowledge data were collected from farmers with a survey. Cross-tabulation results show farmers with secondary and university education are more interested in acoustic technology than those with a primary education and farmers engaged in commercial farming are more interested in technology for monitoring acoustic sources than subsistence farmers. However, nearly all farmers are willing to …

System Design For A Prototype Acoustic Network To Deter Avian Pests In Agriculture Fields, Destiny Kwabla Amenyedzi, Micheline Kazeneza, Ipyana Issah Mwaisekwa, Frederic Nzanywayingoma, Philibert Nsengiyumva, Peace Bamurigire, Emmanuel Ndashimye, Anthony Vodacek

All Grantees Publications

Crop damage attributed to pest birds is an important problem, particularly in low-income countries. This paper describes a prototype system for pest bird detection using a Conv1D neural network model followed by scaring actions to reduce the presence of pest birds on farms. Acoustic recorders were deployed on farms for data collection, supplemented by acoustic libraries. The sounds of pest bird species were identified and labeled. The labeled data were used in Edge Impulse to train a tinyML Conv1D model to detect birds of interest. The model was deployed on Arduino Nano 33 BLE Sense (nodes) and XIAO (Base station) …

Flying Through The Air With The Greatest Of Ease? Evaluation Of Glide Capability In Basal Maniraptoran Theropods, Norah Zoller, Kierra Miller, Michael B. Habib, Hans C. Larsson, T. Alexander Deccechi

Annual Research Symposium

Pterosaurs, a lineage of Mesozoic flying archosaurs, include the largest flying animals ever known. Quetzalcoatlus nortropi a Late Cretaceous representative, had a wingspan of over 10 m and likely weighed more than 200 kg. It presents a combination of features (large head, massive wingspan, shoulder height equivalent to an extant giraYe) that has led to ecological interpretations of it as a major predator in the North American Maastrichtian Biome, perhaps second to only Tyrannosaurus rex. Here we examine the probability of that from an energetics perspective. Despite the great wingspan of Quetzalcoatlus, the body length (gleno- acetabular distance) is relatively …

Terror From The Skies?: Investigating The Energetics And Feeding Ecology Of One Of The Largest Pterosaurs: Quetzalcoatlus Northropi, Kierra Miller, T. Alexander Deccechi

Annual Research Symposium

Our goal is to assess the gut capacity and energetics requirements for Q. northropi in order to understand the role that it played when living.

Evaluating The Risk Posed By Gadolinium In The Grand River Watershed, Johann Memmel

Theses and Dissertations (Comprehensive)

Gadolinium (Gd) is a rare earth element (REE), primarily used in contrast agents for magnetic resonance imaging (MRI), with additional applications in metallurgy, phosphors, neutron shielding, and other niche applications. Both Gd and Gd-based contrast agents (GBCAs, the form used for MRIs) have been detected downstream of wastewater effluent discharges and there is currently little research into the risk this poses to aquatic ecosystems. This study investigated the potential environmental risks of Gd and GBCAs using the Grand River watershed (GRW) in southwestern Ontario as a model ecosystem due to it containing a variety of land uses (urban, industrial, agricultural) …

Dual Suppression Of Glossina Pallidipes Using Entomopathogenic Fungal-Based Biopesticides And Sterile Insect Technique, Fidelis L.O. Ombura, Adly M.M. Abd-Alla, Komivi S. Akutse, Steven Runo, Paul O. Mireji, Rosemary Bateta, Joseck E. Otiwi, Inusa J. Ajene, Fathiya M. Khamis

All Peer-Reviewed Publications

Tsetse flies and trypanosomosis significantly impact bovine production and human health in sub-Saharan Africa, exacerbating underdevelopment, malnutrition, and poverty. Despite various control strategies, long-term success has been limited. This study evaluates the combined use of entomopathogenic fungi (EPF) and the sterile insect technique (SIT) to combat tsetse flies. Eleven EPF isolates were tested against teneral males of Glossina pallidipes, focusing on mortality rates, radial growth, and impacts on fly fitness. Temperature effects on conidial growth, sporulation, and spore yield of SIT-compatible/tolerant strains were also assessed. The fungal isolates significantly influenced mortality rates in both unirradiated and irradiated (SIT-treated) males (p <  0.0001). Metarhizium anisopliae strains ICIPE 20, ICIPE 32, ICIPE 41, ICIPE 62, ICIPE 78, and Beauveria bassiana ICIPE 603 showed higher SIT compatibility/tolerance with LT50 values of 11–30 days, compared to other more virulent isolates with LT50 values of 4–9 days. Temperature significantly affected the radial growth of SIT-compatible EPF strains (p <  0.0001), with M. anisopliae ICIPE 78 exhibiting the fastest conidia growth at 25°C. Spore yield varied significantly across temperatures (15–40°C), and the thermal range for conidia germination of SIT-compatible strains was 8.1–45.4°C, with an optimal range of 26.7–31.1°C. Moreover, infected unirradiated females and irradiated males (donors) successfully transmitted conidia to untreated flies (receivers) without significant differences in survival rates (p = 0.6438) and no observed sex dimorphism. Our findings highlight the potential of combining EPF and SIT as a novel dual approach that could effectively and synergistically suppress tsetse fly populations.

Insect Frass Fertilizer As A Regenerative Input For Improved Biological Nitrogen Fixation And Sustainable Bush Bean Production, Agnes Chepkorir, Dennis Beesigamukama, Harun I. Gitari, Shaphan Y. Chia, Sevgan Subramanian, Sunday Ekesi, Birachi Eliud Abucheli, Jean Claude Rubyogo, Theodore Zahariadis, Gina Athanasiou, Aikaterini Zachariadi, Vasileios Zachariadis, Abdou Tenkouano, Chrysantus M. Tanga

All Peer-Reviewed Publications

Bush bean (Phaseolus vulgaris L.) production is undermined by soil degradation and low biological nitrogen fixation (BNF) capacity. This study evaluated the effect of black soldier fly frass fertilizer (BSFFF) on bush bean growth, yield, nutrient uptake, BNF, and profitability, in comparison with commercial organic fertilizer (Phymyx, Phytomedia International Ltd., Kiambu, Kenya), synthetic fertilizer (NPK), and rhizobia inoculant (Biofix, MEA Fertilizers, Nairobi, Kenya). The organic fertilizers were applied at rates of 0, 15, 30, and 45 kg N ha−1 while the NPK was applied at 40 kg N ha−1, 46 kg P ha−1, and 60 kg K ha−1. The fertilizers …

Comparative Microbiome Diversity In Root-Nodules Of Three Desmodium Species Used In Push-Pull Cropping System, Isack H. Adan, George Ochieng Asudi, Saliou Niassy, Abdul A. Jalloh, Johnstone Mutiso Mutua, Frank Chidawanyika, Fathiya Khamis, Zeyaur Khan, Sevgan Subramanian, Thomas Dubois, Daniel Munyao Mutyambai

All Peer-Reviewed Publications

Background: Desmodium species used as intercrops in push-pull cropping systems are known to repel insect-pests, suppress Striga species weeds, and shift soil microbiome. However, the mechanisms through which Desmodium species impact the soil microbiome, either through its root exudates, changes in soil nutrition, or shading microbes from its nodules into the rhizosphere, are less understood. Here, we investigated the diversity of root-nodule microbial communities of three Desmodium species- Desmodium uncinatum (SLD), Desmodium intortum (GLD), and Desmodium incanum (AID) which are currently used in smallholder maize push-pull technology (PPT). Methods: Desmodium species root-nodule samples were collected from selected smallholder farms in …

Plant-Parasitic Nematodes Associated With Maize, And Their Relationship With Soil Properties In Southern And Southwestern Ethiopia, Abebe W. Aseffa, Beira H. Meressa, Tadele Tefera, Kristina K. Green, Peter Anderson, Esayas Mendesil

All Peer-Reviewed Publications

Maize is an important cereal crop in sub-Saharan Africa (SSA). Plant-parasitic nematodes significantly impact maize production. However, research on maize nematodes in SSA is limited. The current study aimed to assess the occurrences and densities of nematodes associated with maize and to assess the correlation of some soil physicochemical properties with nematodes in southern and southwestern Ethiopia. One hundred and eighty-six soil and root samples were collected from 62 maize fields (31 from Hawassa Zuria and 31 from Mana districts). Eleven plant-parasitic nematode genera were identified. The most important genera of plant-parasitic nematodes identified were Meloidogyne and Pratylenchus, followed by …

Characterisation Of ‘Giant’ Cysts Of The Potato Cyst Nematode, Globodera Rostochiensis, Present In Potato Fields In Kenya, James A. Price, Kelsey Hunt, Newton Nyagah, Calvince Orage, Onesmus Mwaura, Solveig Haukeland, Danny Coyne, John T. Jones

All Peer-Reviewed Publications

Potato production in East Africa is seriously impacted by the potato cyst nematode (PCN), Globodera rostochiensis, where it has been recorded in at least three countries. In Kenya, it is widespread in all major potato-growing regions, often at very high densities. Consecutive cropping of potato on the same land and a sub-tropical climate have influenced PCN biology. For example, unusually large cysts have been regularly recovered. We have analysed the biological properties of these ‘giant cysts’. The giant cysts contained more eggs than those recovered from UK fields. Egg size did not differ from UK populations and there was no …

Tissue-Specific Localization Of Tick-Borne Pathogens In Ticks Collected From Camels In Kenya: Insights Into Vector Competence, Rua Khogali, Armanda Bastos, Joel L. Bargul, Dennis Getange, James Kabii, Daniel Masiga, Jandouwe Villinger

All Peer-Reviewed Publications

Background: Tick-borne pathogen (TBP) surveillance studies often use whole-tick homogenates when inferring tick-pathogen associations. However, localized TBP infections within tick tissues (saliva, hemolymph, salivary glands, and midgut) can inform pathogen transmission mechanisms and are key to disentangling pathogen detection from vector competence. Methods: We screened 278 camel blood samples and 504 tick tissue samples derived from 126 camel ticks sampled in two Kenyan counties (Laikipia and Marsabit) for Anaplasma, Ehrlichia, Coxiella, Rickettsia, Theileria, and Babesia by PCR-HRM analysis. Results: Candidatus Anaplasma camelii infections were common in camels (91%), but absent in all samples from Rhipicephalus pulchellus, Amblyomma gemma, Hyalomma dromedarii, …

Chitin-Enriched Insect Frass Fertilizer As A Biorational Alternative For Root-Knot Nematode (Meloidogyne Incognita) Management, James Kisaakye, Dennis Beesigamukama, Solveig Haukeland, Sevgan Subramanian, Paul K. Thiongo, Segenet Kelemu, Chrysantus M. Tanga

All Peer-Reviewed Publications

Root-knot nematodes (Meloidogyne spp.) are serious pests of most food crops, causing up to 100% yield loss. Nevertheless, commercial nematicides are costly and harmful to the environment. While the nematicidal potential of crustacean and synthetic chitin has been demonstrated globally, research on the potential of insect-derived chitin for nematode control has received limited attention. Here, seven chitin-fortified black soldier fly frass fertilizer extracts (chFE) were assessed for their suppressiveness of Meloidogyne incognita and impacts on spinach growth in comparison with a commercial nematicide using in vitro and in vivo bioassays. The performance of chFE and control treatments was assessed by …

Fishes In Murky Waters: Effects Of Total Suspended Solids On Fish Gills And Performance, Xena Montoya

Theses and Dissertations (Comprehensive)

Total suspended solids (TSS) naturally occur in aquatic habitats, but climate change and other anthropogenic disturbances can lead to increased levels. Exposure to high levels of TSS has the potential to damage fish gills through abrasion, leading to impairment of gill function and fish physiology. However, little work has been done exploring the linkages between TSS-induced gill damage and animal performance. Therefore, we tested the hypothesis that TSS damages gill structure, causing gill dysfunction and reducing swimming performance. We exposed salmonids (rainbow trout, brook trout and cutthroat trout) and non-salmonids (fathead minnow and longnose dace) to different TSS concentrations (0-1000 …

Integrating Biodiversity Protection And Climate Mitigation In Nature-Based Climate Solutions: An Indicator Analysis, Tatyana Feiner

Theses and Dissertations (Comprehensive)

Climate change and biodiversity loss have been recognized as complex, interconnected issues that require synergistic and mutually reinforcing policy solutions. Given the ambitious commitments by the Canadian government to abate the two “wicked problems”, this study investigates whether the government has constructed a policy framework that synthesizes climate and biodiversity concerns through policy integration and mainstreaming processes. Through a semi-systematic and comprehensive content analysis approach, this study assesses the degree to which biodiversity protection and climate mitigation have been effectively mainstreamed into federal policies, programs, and instruments. Specifically, the study constructs an evaluative framework based on established “best practices” of …

Social Interaction, Social Cognition, And Personality In Gartersnakes And Ball Pythons, Morgan Skinner

Theses and Dissertations (Comprehensive)

Snakes are often considered non-social animals. However, this is mostly an untested assumption and the limited research that has been done has shown that snakes interact socially when given the opportunity. Here, the complexity of snake social interactions was explored through a social cognition and personality lens. Group and individual behavioural assays were used to explore flexibility and consistency in social interactions. The results provide evidence that elucidate the function, development, and evolution of these behaviours in snakes. In the first experimental chapter, chapter 2, social network analysis was used to provide a detailed description of aggregation behaviour in 4 …

A Comparative In Vitro Investigation Of Rainbow Trout Vig-3 And Human Isg15, Kristof Jenik, Sarah J. Poynter, Shanee Herrington-Krause, Kayla Samms, Nichole Sanchez Diaz, Stephanie J. Dewitte-Orr, Tania Rodriguez-Ramos, Brian Dixon, Adebisi Sanyaolu, Tamiru Alkie, Bryce M. Warner, Nikesh Tailor, Shawna Semple

Theses and Dissertations (Comprehensive)

The aquaculture industry is a big part of the global economy, supplying food and supporting many livelihoods, yet it faces formidable challenges from diverse aquatic pathogens, especially viruses. Effective antiviral treatments are lacking for both humans and economically significant farmed fish like rainbow trout (Oncorhynchus mykiss). When viruses invade host cells, pattern recognition receptors detect viral components, initiating intracellular signaling and type I interferon (IFN-I) production. IFN-I triggers interferon-stimulated genes (ISGs) that establish an antiviral state in infected and nearby cells, curbing viral spread. In rainbow trout, a particularly understudied ISG is viral hemorrhagic septicemia virus (VHSV)-induced gene 3 (vig-3), …

Regional Variation In The Role Of Humidity On City-Level Heat-Related Mortality, Multi-Country Multi-City (Mcc) Collaborative Network, Patrick Goodman

Articles

The rising humid heat is regarded as a severe threat to human survivability, but the proper integration of humid heat into heat-health alerts is still being explored. Using state-of-the-art epidemiological and climatological datasets, we examined the association between multiple heat stress indicators (HSIs) and daily human mortality in 739 cities worldwide. Notable differences were observed in the long-term trends and timing of heat events detected by HSIs. Air temperature (Tair) predicts heat-related mortality well in cities with a robust negative Tair-relative humidity correlation (CT-RH). However, in cities with near-zero or weak positive CT-RH, HSIs considering humidity provide enhanced predictive power …

Addressing The Complexity Of Spatial Teaching: A Narrative Review Of Barriers And Enablers, Ergi Bufasi, Ting Jun Lin, Ursa Benedicic, Marten Westerhof, Rohit Mishra, Dace Namsone, Inese Dudareva, Sheryl Sorby, Lena Gumaelius, Remke M. Klapwijk, Jeroen Spandaw, Brian Bowe, Colm O'Kane, Gavin Duffy, Marianna Pagkratidou, Jeffrey Buckley

Articles

Extensive research has established that spatial ability is a crucial factor for achieving success in Science, Technology, Engineering, and Mathematics (STEM). However, challenges that educators encounter while teaching spatial skills remain uncertain. The purpose of this study is to develop a research framework that examines the interrelationships, barriers, and enablers amongst various educational components, including schools, teachers, students, classrooms, and training programs, that are encountered when teaching for spatial ability development. A thorough examination of international research, in combination with a detailed review of the primary Science and Mathematics curricula in Ireland, Latvia, Sweden, and the Netherlands, is undertaken to …

Savings Associated With Surgical Aortic Valve Replacement With A Resilia Tissue Valve Based On Seven-Year Commence Trial Results, Tom Nguyen

All Publications

Background: Bioprostheses with RESILIA tissue demonstrate a reduction in calcification and improve health outcomes in pre-clinical and clinical studies. Prior economic analyses which relied on 5 years of evidence from the COMMENCE trial demonstrate financial savings for RESILIA tissue valves relative to mechanical valves after surgical aortic valve replacement (SAVR). Given the recent release of 7-year COMMENCE data, this economic evaluation updates the estimate for long-run savings of bioprosthetic valves with RESILIA.

Methods: Simulation models estimated disease progression across two hypothetical SAVR cohorts (tissue vs. mechanical) of 10,000 patients each in the US. The primary comparison calculated the SAVR-related expenditures …