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2024

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Chemical Synthesis And Biological Application Of Sensitive Rna, Alexander T. Apostle Jan 2024

Chemical Synthesis And Biological Application Of Sensitive Rna, Alexander T. Apostle

Dissertations, Master's Theses and Master's Reports

In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications specific to RNA. Epitranscriptomics can give us a new approach to understanding and treating RNA viruses, like SARS-CoV-2. Given viruses are often found modified by human epitranscriptomic machinery, understanding how these modifications can modulate virulence is of high interest. We have shown that the N1-methyladensoine modification causes RNA synthesis termination in the SARS-CoV-2 replication complex, and thus may explain the differences in symptoms observed in individuals. …


Understanding The Controls Of Seasonal Stream Temperature And Hydrological Monitoring Of Forested Watersheds In The Western Upper Peninsula Of Michigan, Eli A. Paulen Jan 2024

Understanding The Controls Of Seasonal Stream Temperature And Hydrological Monitoring Of Forested Watersheds In The Western Upper Peninsula Of Michigan, Eli A. Paulen

Dissertations, Master's Theses and Master's Reports

Accurately predicting stream temperature is vital to protect the environment and its most sensitive aquatic species. Tools for forecasting stream temperature rely on in situ data that affect thermal response of natural water systems. Stream and meteorological data were analyzed from the western Upper Peninsula of Michigan for the 2016-2023 water years to determine which factors affected stream temperatures. Through the application of multivariable linear regression models, our analysis identified air temperature as the primary determinant of stream temperature. However, the air-stream temperature relationship varied significantly over temporal scales, improving with increasing in time averaging. The air-stream temperature relationship was …


Trophic Interactions Of Sympatric Cyprinodontiform Fishes Inhabiting Louisiana Saltmarshes, Ryan Heines Jan 2024

Trophic Interactions Of Sympatric Cyprinodontiform Fishes Inhabiting Louisiana Saltmarshes, Ryan Heines

Dissertations, Master's Theses and Master's Reports

Resident saltmarsh nekton, namely Cyprinodontiform fishes, play key ecological roles in supporting terrestrial and aquatic food webs. These fishes are highly abundant across the saltmarsh landscape of coastal Louisiana and have evolved to tolerate the highly variable environmental conditions that are characteristic of these habitats. The objective of this research is to consider mechanisms enabling this diverse community of fishes to cooccur in the spatially limited saltmarsh habitats of coastal Louisiana. In Chapter 2, bulk stable isotope ratios of carbon (δ13C), sulfur (δ34S) and nitrogen (δ15N) were used to quantify the intra- and inter-specific resource use of six sympatric Cyprinodontiform …


Modeling Pulsatile Flows Using Truly Incompressible Finite Volume Lattice Boltzmann Model, Akshay S. Dongre Jan 2024

Modeling Pulsatile Flows Using Truly Incompressible Finite Volume Lattice Boltzmann Model, Akshay S. Dongre

Dissertations, Master's Theses and Master's Reports

The present study addresses the compressibility error inherent in the standard Lattice Boltzmann Method (LBM) and LBM’s restriction to uniform Cartesian meshes. To mitigate the compressibility error, an incompressible LBM (iLBM) model has been incorporated into the finite volume framework using a cell-centered finite volume approach, leveraging the simplicity of the LBM algorithm for irregularly shaped flow domains with unstructured meshes. Monotonic Upstream-centered Scheme for Conservation Laws (MUSCL) and linear reconstruction (LR) schemes have been used to compute convective fluxes across the cell interfaces with boundary conditions implemented using the second-order accurate Non-Equilibrium Extrapolation (NEE) method.

The finite volume iLBM …


Phase Field Modeling Of Fracture And Phase Separation Using Numerical Methods And Machine Learning, Revanth Mattey Jan 2024

Phase Field Modeling Of Fracture And Phase Separation Using Numerical Methods And Machine Learning, Revanth Mattey

Dissertations, Master's Theses and Master's Reports

Phase field modeling is a crucial tool in scientific and engineering disciplines due to its ability to simulate complex phenomena like phase transitions, interface dynamics, and pattern formation. It plays a vital role in understanding material behavior during processes such as solidification, phase separation, and fracture mechanics. Particularly in fracture mechanics, phase field modeling can be utilized to predict the crack path in complex materials. Understanding the failure behavior is vital for applications of any material. The specific contributions to the field of phase field fracture mechanics, are, Firstly, we propose a novel phase field fracture model to simulate the …


Encyclopedia Of Gardening For Colored Children (2024) By Jamaica Kincaid, Maughn Rollins Gregory Jan 2024

Encyclopedia Of Gardening For Colored Children (2024) By Jamaica Kincaid, Maughn Rollins Gregory

Picture Books

In relating the origins, biological features, and uses of several familiar and unfamiliar plants, this Encyclopedia simultaneously offers a primer on colonialism, slavery, and genocide. Adults sharing this book with children should be led by children’s curiosity, but should also help them cultivate a vocabulary and historical understanding of oppression.


Increasing Minority Student Enrollment: An Applied Research Study On Increasing The Enrollment Of Minority Students In Advanced Placement Courses, Tamekia Helm Jan 2024

Increasing Minority Student Enrollment: An Applied Research Study On Increasing The Enrollment Of Minority Students In Advanced Placement Courses, Tamekia Helm

Electronic Theses and Dissertations

Addressing the disparity in Advanced Placement (AP) course enrollment among minority students at Greater High School is the focus of this research. Through an extensive review of the literature, the study examines the various factors contributing to this gap, including access limitations and systemic barriers. Additionally, teacher perceptions, student attitudes, and parental involvement are explored to understand the influence on AP course enrollment decisions. Utilizing a mixed-methods approach, including surveys and interviews, data is collected from students, teachers and parents to gain comprehensive insights.

Proposed solutions to enhance AP course enrollment include targeted outreach initiatives and support for minority students. …


Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker Jan 2024

Indirect And Direct Pathways Of Migratory Shorebird Effects On Nitrogen Cycling Within Temporarily Flooded Agricultural Fields, Victoria Blocker

Electronic Theses and Dissertations

The global human population continues to grow exponentially, and agriculture will need to become more productive to meet growing food demands. Humans also need clean water and other services that ecosystems provide. This requires future agriculture production to reduce environmental and wildlife impacts through improved efficiencies and best management practices. Migratory shorebirds rely on wetlands throughout North and South America as stopover habitat for rest and refueling during migration. Temporarily flooded farmlands in the Mississippi Delta have proven to be beneficial locations for shorebirds during migrations along the central flyway. This conservation practice also enhances wetland properties that promote excess …


The Role Of Place Of Birth And Residence In Puerto Rican Health Disparities: Evidence From Disability Prevalence Among Archipelago- Vs. Mainland-Born Puerto Ricans, Mara Getz Sheftel, Frank W. Heiland Jan 2024

The Role Of Place Of Birth And Residence In Puerto Rican Health Disparities: Evidence From Disability Prevalence Among Archipelago- Vs. Mainland-Born Puerto Ricans, Mara Getz Sheftel, Frank W. Heiland

Publications and Research

Objectives: This paper provides new estimates of disability prevalence for the archipelago and mainland-residing Puerto Rican populations ages 40 and above and compares disability by place of birth and place of residence to investigate drivers of middle and older age health.

Methods: Large nationally representative samples from 2013 to 2017 American Community Survey and Puerto Rico Community Survey data are used to estimate age-specific disability prevalence for archipelago-born/archipelago-residing, archipelago-born/mainland-residing, mainland-born/mainland-residing Puerto Ricans.

Results: Mainland-born/ mainland-residing Puerto Ricans have the lowest age-adjusted disability rates and archipelago-born/archipelago-residing Puerto Ricans have the highest rates. Differences in education explain part of this disparity.

Discussion: …


Development Of New Radiotracers For Positron Emission Tomography Targeting C-X-C Chemokine Receptor Type 4 In Cancers, Piyapan Suwattananuruk Jan 2024

Development Of New Radiotracers For Positron Emission Tomography Targeting C-X-C Chemokine Receptor Type 4 In Cancers, Piyapan Suwattananuruk

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study aimed to develop novel positron emission tomography (PET) tracers for C-X-C chemokine receptor type 4 (CXCR4) imaging. [68Ga]Ga-TD-01 and [18F]PICO-F were designed as PET tracers based on the molecular scaffolds of two potent CXCR4 antagonists, TIQ15 and PICO. TIQ15 was used to prepare a bifunctional (BFC) to facilitate 68Ga-labeling while structural modification of PICO was made to obtain a precursor, PICO-Br for 18F-labeling. The BFC, TD-01 was obtained in a moderately high yield (61%) via the conjugation of TIQ15 with a chelator derivative and successfully radiolabeled with 68Ga to yield [68Ga]Ga-TD-01, a PET tracer. For 18F-based tracer, the …


Asset Mindsets And Blended Learning Environments: A Career Educator’S Autoethnography, Elizabeth A. Buffington Jan 2024

Asset Mindsets And Blended Learning Environments: A Career Educator’S Autoethnography, Elizabeth A. Buffington

Education Dissertations

This autoethnography explores a career educator's personal and professional journey transitioning from a deficit mindset to an asset based mindset. The author examines teaching practices through critical self-inquiry, reflecting on how technology, including Blended Learning Models (Clayton Christensen Institute, 2013), student-centered learning, and an asset mindset enhance educational experiences. The dissertation integrates key frameworks such as Technological Pedagogical Content Knowledge (TPACK) (Mishra, 2019), Universal Design for Learning (UDL) CAST (2024), and the concept of Funds of Knowledge (FoK) (Gonzalez, Moll & Amanti, 2005) to demonstrate how educators can adapt instruction as reflexive practitioners Cunliffe, 2016) to support diverse learners. …


Review Of Queer Kinship: Race, Sex, Belonging, Form, First Edition, Patrick Barchett Jan 2024

Review Of Queer Kinship: Race, Sex, Belonging, Form, First Edition, Patrick Barchett

Nebraska Anthropologist

Review of Queer Kinship: Race, Sex, Belonging, Form, 1st edition, edited by Tyler Bradway and Elizabeth Freeman. 2022. Duke University Press, Durham, North Carolina, USA. vii + 352 pp. Reviewed by Patrick Barchett, University of Nebraska-Lincoln.

Due widely to the inaccessible nature of “nonnormative” sexualities and genders in many ethnographic studies, queer kinship tends to be left out of many kinship classes and discussions. However, Queer Kinship: Race, Sex, Belonging, Form (edited by Tyler Bradway and Elizabeth Freeman) discusses not only queer kinship in the sense of LGBTQ+ kinship, but also other forms of nonnormative kinship structures, such …


Skin In The Game Revisited, Eric K. Ward Jan 2024

Skin In The Game Revisited, Eric K. Ward

Lewis & Clark Law Review

No abstract provided.


Using A "Moves To Innocence" Approach To Dissect And Debunk The Claim That Critical Race Theory Is Antisemitic, Diane Kemker Jan 2024

Using A "Moves To Innocence" Approach To Dissect And Debunk The Claim That Critical Race Theory Is Antisemitic, Diane Kemker

Lewis & Clark Law Review

In the United States, law and policy have most frequently reflected dominant white Christian majority interests. Critical Race Theory (CRT) offers powerful tools for understanding our history and situation, including that of American Jews, and how the social positions and interests of American Blacks and Jews, real and perceived, have intersected, sometimes aligning, sometimes diverging, and sometimes conflicting. And yet, among other charges leveled against it, Critical Race Theory is frequently accused of being antisemitic.

Intentionally or not, this charge delegitimizes and discredits CRT, and therefore advances the aims of all who oppose it for any reason, including white supremacists …


Exploring Market Segmentation For Autonomous Ferries, Ashari Fitra Rachmannullah, Taih Cherng Lirn, Kuo Chung Shang Jan 2024

Exploring Market Segmentation For Autonomous Ferries, Ashari Fitra Rachmannullah, Taih Cherng Lirn, Kuo Chung Shang

Journal of Marine Science and Technology–Taiwan

This study aims to investigate the determinants that underlie psychographic segmentation in the domain of autonomous ferries (AFs) by using the theory of planned behaviour (TPB) as a guiding theoretical construct. The paper focuses on Indonesian individuals who had previously utilised conventional ferry services. TPB was applied as a catalyst to identify possible market segmentation among potential AF passengers. In this study, cluster analysis is used to differentiate passengers by their perception of using AFs. The results identified three market segments through cluster analysis based on passengers’ perceptions of using AFs: Resource-Limited, Resource-Capable, and Value-Optimistic. Among these segments, the Resource-Capable …


Adaptive Prediction Horizon Energy-Saving Collision-Free Mpc Of Ships Based On Ship-Shore Cooperation, Han Xue, Enjie Yang Jan 2024

Adaptive Prediction Horizon Energy-Saving Collision-Free Mpc Of Ships Based On Ship-Shore Cooperation, Han Xue, Enjie Yang

Journal of Marine Science and Technology–Taiwan

ABSTRACT:In order to perform the close association between ship maneuvering control and energy consumption through the control strategy, this paper designs an adaptive prediction horizon based energy-saving robust nonlinear model predictive control (APHERNMPC) for underactuated ships to deal with the actual control and state constraints during berthing based on ship-shore cooperation. An improved Emperor Penguin Optimizer (EPO) method is proposed for collision avoidance decision. To solve the problems of falling into local optimum and reducing the convergence speed, the traditional EPO is improved based on Sobol sequence in order to enhance the diversity and ergodicity of the population. The multi-ship …


Research And Design A Lifeboat Virtual Reality Simulation System For Maritime Safety Training In Vietnam, Nguyen Dinh Thach, Nguyen Van Hung Jan 2024

Research And Design A Lifeboat Virtual Reality Simulation System For Maritime Safety Training In Vietnam, Nguyen Dinh Thach, Nguyen Van Hung

Journal of Marine Science and Technology–Taiwan

Ensuring maritime safety and security is crucial for all nations. Training trainees and operational officers in this field aims to enhance their professional skills and ability to manage and resolve incidents at sea. This article outlines the development of a lifeboat simulation system that integrates Virtual Reality (VR) technology in accordance with international maritime regulations. It describes the creation of an algorithm designed to optimize data transmission between simulation systems using the ant colony optimization technique in conjunction with intelligent control algorithms on Unity 3D software for human interaction. In particular, the system combines training with a maritime simulation framework …


Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr Jan 2024

Periodontal Regeneration Related To Periodontitis Treated By Garden Cress And Ozone Therapy. (Randomized Clinical &Experimental Study), Zienab S. Farid, Doaa Adel Habba, Gihan Adel Balbola, Noura Mohammed Bakr

Journal of Medicine in Scientific Research

Objective: In this article, garden cress and ozone were evaluated for their potential therapeutic properties of PDL and resorption of alveolar bone in the periodontal tissues based on rats' experimental periodontitis and to assess the clinical effectiveness of local application of garden cress and ozone for treatment and management of periodontitis patients using scaling and root planing. Methodology: Thirty mature Wistar male albino rats. Three groups of rats were formed; periodontitis without treatment, periodontitis with garden cress, and periodontitis plus ozone therapy. The present study also included thirty periodontitis Patients were randomly allocated to one of three groups of ten …


The Rage Gene Crucial Function In The Etiology And Consequences Of Type I Diabetes, Amal A. Mohamed, Mohamed O. Mahmoud, Gamil M. Abdallah, Nada S. Ali, Mona Abdelmotaleb Abdelfatah Hussein, Ibrahim T. Ibrahim Jan 2024

The Rage Gene Crucial Function In The Etiology And Consequences Of Type I Diabetes, Amal A. Mohamed, Mohamed O. Mahmoud, Gamil M. Abdallah, Nada S. Ali, Mona Abdelmotaleb Abdelfatah Hussein, Ibrahim T. Ibrahim

Journal of Medicine in Scientific Research

Type I Diabetes, among the ten greatest causes of mortality worldwide, is estimated to afflict 642 million individuals by 2040. It is an auto-immune illness brought on by an association of environmental and genetic variables. that cause T lymphocytes to destroy insulin-producing β-cells. Its prevalence continues to rise by 3-4% annually worldwide, enhancing the risk of mortality. So, the idea of diabetic kidney disease (DKD) is widely established, and systemic treatment is essential. RAGEs are linked to inflammatory disorders that exist in a variety of TID-related cells; especially T cells. Variations in circulating RAGE concentrations have been linked to a …


The Role Of Renal Resistive Index (Rri) As Early Non Invasive Predictor Of Renal Dysfunction And Relation To Estimated Gfr In Nafld Patients, Atteyat Aboelmaged Semeya, Hala Abd-Elhameed Tabl, Naglaa F. Al-Mihy Jan 2024

The Role Of Renal Resistive Index (Rri) As Early Non Invasive Predictor Of Renal Dysfunction And Relation To Estimated Gfr In Nafld Patients, Atteyat Aboelmaged Semeya, Hala Abd-Elhameed Tabl, Naglaa F. Al-Mihy

Journal of Medicine in Scientific Research

Background: Non-alcoholic fatty liver (NAFLD) is the diagnosis of fatty infiltration of the liver (steatosis) in the absence of other reasons, done through histology or imaging, with or without fibrosis or inflammation. We sought to ascertain the function of RRI as early non-invasive predictor of renal dysfunction and the relationship between eGFR and RRI in patients with NAFLD.

Methods: This cross-sectional research comprised 250 patients and controls gathered from outpatient clinic of the Hepatogasteroenterology Department, Benha teaching Hospitals. They were split into three groups: group 1 consisted of 100 NASH patients, fibrosis-free or with a history of the condition; group …


Oral Collagen Supplementation In 2nd Degree Burn And Chronic Pressure Ulcers, Wesam Ibrahem Homouda, Helmy Ahmed Soliman, Esayed Hussien Elmokadem Jan 2024

Oral Collagen Supplementation In 2nd Degree Burn And Chronic Pressure Ulcers, Wesam Ibrahem Homouda, Helmy Ahmed Soliman, Esayed Hussien Elmokadem

Journal of Medicine in Scientific Research

Background: Healing of wounds requires adequate intake of protein, iron, Vitamin-C and zinc. In case of deficiency in the dietary intake, supplements may be prescribed. Collagen-peptide supplements can enhance skin hydration, elasticity, and reduce wrinkles. Burns, caused by various agents, severely damage skin layers. Pressure ulcers occur when prolonged pressure on the skin leads to tissue ischaemia, disrupting nutrition and oxygen supply, resulting in tissue necrosis. Systematic reviews show that oral collagen, either intact or hydrolyzed, effectively improves skin health.

Objectives: This article aim to evaluate the effect of oral collagen intake as a healing promoting supplementation in management of …


Superpowers With Villainous Objectives: How The Executive Branch’S Immigration Enforcement “Powers” Utilize Technology To Violate Noncitizens’ Privacy, Nina-Simone Edwards Jan 2024

Superpowers With Villainous Objectives: How The Executive Branch’S Immigration Enforcement “Powers” Utilize Technology To Violate Noncitizens’ Privacy, Nina-Simone Edwards

Library Scholarship

The United States border, for noncitizens, has a unique quality to it. Each time a noncitizen crosses that border, they are no longer private individuals. They can no longer choose to give up their information–instead, there is a forced exchange: data for entry. Who they are, what they are, and everything that connects them to the world is given up in exchange for a new life in a new land. Once the border is crossed, noncitizens no longer have the privacy that they may have known before. This Note first builds on scholarship theorizing that noncitizens do have a right …


Impact Of An Integrated Yoga And Body Image Program On Body Image, Self-Esteem, And Physical Activity In African American Adolescent Girls, Natalie Thompson Jan 2024

Impact Of An Integrated Yoga And Body Image Program On Body Image, Self-Esteem, And Physical Activity In African American Adolescent Girls, Natalie Thompson

Doctor of Nursing Practice (DNP)

The literature posits body dissatisfaction in the adolescent maturational period is a risk factor for the development of numerous negative health outcomes. These include but are not limited to; depressive symptoms, suicide, low self-esteem, unsafe sexual behaviors, onset of smoking, poor academic achievement, and overweight/obesity. The female adolescent African American population suffers disparately from health issues associated with cultural and normative influences that impact body image, self-esteem, and physical activity. Hence, the importance of early risk assessment and intervention. In the literature, school-based body image programs have been shown to improve body image in adolescent girls. African American girls represent …


Microfluidic Flowmeter Based On A Liquid Crystal-Filled Nested Capillary, Zhe Wang, Arun Kumar Mallik, Fangfang Wei, Zhuochen Wang, Anuradha Rout, Rayhan Habib Jibon, Qiang Wu, Yuliya Semenova, University College Cork Jan 2024

Microfluidic Flowmeter Based On A Liquid Crystal-Filled Nested Capillary, Zhe Wang, Arun Kumar Mallik, Fangfang Wei, Zhuochen Wang, Anuradha Rout, Rayhan Habib Jibon, Qiang Wu, Yuliya Semenova, University College Cork

Articles

Microfluidic flowmeters are a powerful and highly accurate tool, enabling precise monitoring and measurements of flows of gases and fluids in a range of applications. Here we proposed and experimentally demonstrated a whispering gallery modes flowmeter composed of a liquid crystal-filled nested capillary. Whispering gallery modes are excited by a tapered fiber coupled perpendicularly to the nested capillary. The air flowing through the capillary cools it down, which leads to a temperature-induced change of the refractive index of the nematic liquid crystals. This change in turn leads to a spectral shift of the whispering gallery modes resonances, which can be …


Breaching Bad: Bad Faith Insurance Claims And Standards Across The United States, Scott W. Schwartz Jan 2024

Breaching Bad: Bad Faith Insurance Claims And Standards Across The United States, Scott W. Schwartz

NYLS Law Review

No abstract provided.


Research On The Soft Power Of Thai Traditional Food Culture Under The Process Of Globalization, Lu Han Jan 2024

Research On The Soft Power Of Thai Traditional Food Culture Under The Process Of Globalization, Lu Han

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research explores the role of Thai traditional food culture as a form of soft power in the context of globalization. According to Joseph S. Nye, Soft power operates through the resources of culture, political ideals, and foreign policies. Influenced by factors such as history, geography, climate, and social development, Thai traditional food culture has integrated the characteristics of multiple cultures with its inclusive and innovative ideas to form a unique culture. Through globalization, Thai food culture has gained widespread popularity. This research analyzes the mechanisms by which Thai food culture promotes Thailand’s soft power, including nation branding, gastro-diplomacy, tourism, …


A Study Of Developing Artificial Coral Innovation In Line With The Context Of Promoting Thailand’S Economy And Society, Chawin Poomee Jan 2024

A Study Of Developing Artificial Coral Innovation In Line With The Context Of Promoting Thailand’S Economy And Society, Chawin Poomee

Chulalongkorn University Theses and Dissertations (Chula ETD)

This research aimed to develop innovative artificial reef technology to align with the context of promoting the Thai economy and society. The objectives were to understand the development direction of artificial reefs to meet the needs of tourists and conservationists, explore the feasibility of introducing new technology into artificial reef production, and study methods to reduce environmental destruction caused by reef deployment. The research employed exploratory and qualitative research methods, including in-depth interviews with a target group of 10 individuals and questionnaire surveys to study consumer behavior and product acceptance among a general consumer group of 100 individuals. Data analysis …


Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon Jan 2024

Understanding Angler Responses To Fish Stocking Programs Across South Dakota, Riley L. Mounsdon

Electronic Theses and Dissertations

Fisheries management is a complex process that often requires consideration of many factors to be implemented effectively. Stocking is one of the most often used fisheries management techniques for addressing a myriad of issues in the fisheries field. Stocking is also one of the largest expenses for many fisheries management agencies. Due to license sale declines, management actions including stocking, are being evaluated by many agencies to determine if there are ways to improve efficiency and effectiveness to reduce costs and enhance angler participation. For my second chapter, I evaluated the current fish stocking decision-making process within South Dakota Game, …


Hsp70 Is A Critical Regulator Of Hsp90 Inhibitor's Effectiveness In Preventing Hcl-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-Nkansah, Christiana Dimitropoulou, John D. Catravas Jan 2024

Hsp70 Is A Critical Regulator Of Hsp90 Inhibitor's Effectiveness In Preventing Hcl-Induced Chronic Lung Injury And Pulmonary Fibrosis, Ruben M. L. Colunga Biancatelli, Pavel A. Solopov, Tierney Day, Betsy Gregory, Michael Osei-Nkansah, Christiana Dimitropoulou, John D. Catravas

Bioelectrics Publications

Exposure to hydrochloric acid (HCl) can provoke acute and chronic lung injury. Because of its extensive production for industrial use, frequent accidental exposures occur, making HCl one of the top five chemicals causing inhalation injuries. There are no Food and Drug Administration (FDA)-approved treatments for HCl exposure. Heat shock protein 90 (HSP90) inhibitors modulate transforming growth factor-β (TGF-β) signaling and the development of chemical-induced pulmonary fibrosis. However, little is known on the role of Heat Shock Protein 70 (HSP70) during injury and treatment with HSP90 inhibitors. We hypothesized that administration of geranylgeranyl-acetone (GGA), an HSP70 inducer, or gefitinib (GFT), an …


Understanding The Effects Of Hormone Treatments On The Transgender Singer: A Pedagogical Study And Voice Studio Guide, Erin M. Hannon Jan 2024

Understanding The Effects Of Hormone Treatments On The Transgender Singer: A Pedagogical Study And Voice Studio Guide, Erin M. Hannon

Theses and Dissertations--Music

Transitioning from one gender to another can be an arduous and emotionally charged experience, accompanied by many physical and mental transformations. The journey of self-discovery and vocal explorations is both unique and deeply personal. Modifications that emerge in an individual's vocal characteristics have a profound influence on their capacity to communicate and express themselves.

Transgender vocal students and professional singers must navigate the delicate balance between their vocal and gender identities while considering the possible risks of Gender Affirming Hormone Therapy. Though these therapies may significantly alter one's appearance and overall well-being, they are also capable of causing notable declines …