Digital Commons Network^™

Characterizing The Reproductive System Of Avrainvillea In HawaiʻI, Brinkley Mikayla Thornton

All ETDs from UAB

Sex has generated incredible life cycle diversity across eukaryotes. Differences in the timing of meiosis and fertilization have generated tremendous variation in the duration of haploid and diploid phases. To understand what drives eukaryotic sexual diversity, there remains a need to determine the rates of sexual and asexual reproduction in natural populations. Moreover, life cycle diversity is predicted to be correlated with the reproductive system. Yet, most studies on reproductive variation have focused on diploid or diploid dominant organisms, hindering the ability to understand sex. Macroalgae can serve as useful models to overcome this limitation via life cycle and reproductive …

The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry

All ETDs from UAB

Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …

Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder

All ETDs from UAB

EVALUATION OF FEED INTAKE, GROWTH, AND REPRODUCTION IN THE ZEBRAFISH, DANIO RERIO, FED A GEL-BASED DIET THOMAS LOGAN HOLFELDER BIOLOGY ABSTRACT The zebrafish, Danio rerio, is a valuable pre-clinical model, aiding human health understanding and translational aquaculture. Comprehensive documentation of the culture of this model exists, with ongoing efforts to optimize husbandry requirements, particularly in the areas of diet and nutrition. Labor or mechanical costs related to feeding are high in most laboratories and alternative protocols to reduce feed handling would be beneficial and could allow the capability to monitor feed consumption. A commercially produced gel-based diet has a high …

Oe@Kcc: Crash Course In Open Education, Shawna M. Brandle

Open Educational Resources

These slides cover a very fast introduction to open education for Kingsborough faculty and staff.  They are full of lots of links to helpful resources, so please use/adapt this however you like!

Analysis Of The Immune Response After Readministration Of A Novel Aav6 Gene Therapy Containing Tlr9 Inhibitory Sequences, Sarah Elysse Allen

MUSC Theses and Dissertations

Therapeutic options for the treatment of Surfactant Protein-B (SP-B) deficiency, an autosomal recessive disorder that leads to fatal respiratory distress, are extremely limited with the exception of double lung transplantation. One method for treating this monogenic lung disease is with adeno-associated virus (AAV) gene therapy treatment that delivers the hSFTPB transgene into the lungs. The transient nature of AAV transgene expression led to a need for sustained gene expression, which could possibly be achieved through redosing. The main obstacle with redosing is the innate immune response and subsequent inflammatory response pathways that are activated after recognition of unmethylated CpG motifs …

Adult Learners Self-Derive New Knowledge Through Integration Of Novel Information And Prior Knowledge And Are More Successful With Reactivation, Jayantika Chakraborty, Alena G. Esposito

Psychology

Self-derivation through integration is the process of integrating novel facts and producing new knowledge never directly taught. Knowledge integration has been studied with the presentation of two novel facts. However, in educational settings, individuals are required to integrate new information with prior knowledge learned days, months, or years earlier. Prior knowledge robustly predicts learning outcomes, but less is known about self-derivation through the integration of new information with prior knowledge. Thus, in Study 1, we examined adults' (n = 25) memory integration of new facts with prior knowledge. The participants had 52% accuracy in self-derivation. In Study 2 (n = …

Conducting Research Within The Acronym: Problematizing Lgbtiq+ Research In Psychology, Amanda Klysing, Marta Prandelli, Miguel Roselló-Peñaloza, Daniel Alonso, Madison Gray, Jessica Glazier, Sarah Swanson, Yu-Chi Wang

Psychology

LGBTIQ+ research acknowledges shared experiences of groups marginalized due to gender identities, sexualities, and sex characteristics. This universalist coalition approach has resulted in much affirmational research and progressive policy development. However, it risks homogenizing the unique experiences and needs of specific groups; a risk lessened by a particularist subgroup approach. In this theoretical paper, we reflect on the challenges of a coalition or subgroup approach by considering interdependencies and boundaries between sex, gender, and sexuality-based identities. Through tracing the historical development of LGBTIQ+ research and activism and using examples from intersex studies, intersectionality, and political actions, we explore tensions between …

“Saying ‘I'M Not Okay’ Is Extremely Risky”: Postpartum Mental Health, Delayed Help-Seeking, And Fears Of The Child Welfare System Among Queer Parents, Abbie E. Goldberg, Reihonna Frost

Psychology

Parent mental health challenges in the postpartum and early parenthood have profound implications for parent, child, and family well-being. Little research has focused on postpartum mental health challenges and barriers to help-seeking among queer birthing people, including members of this community who may be particularly vulnerable to mental health difficulties, such as queer cis women partnered with men, trans/nonbinary parents, and queer parents who are young, low-income, and/or of color. This mixed-methods study of queer parents (n = 99), all of whom were assigned female at birth (AFAB) and gave birth to a child within the past several years, explores …

Behavioral Interactions And Mate Compatibility Influence The Reproductive Success Of New England Cottontails (Sylvilagus Transitionalis) In A Conservation Breeding Program, Hannah Petit, Louis Perrotti, Justin T. Richard

Fisheries, Animal and Veterinary Sciences Faculty Publications

Wild populations of New England cottontails (NECs, Sylvilagus transitionalis) are declining and occupy a small proportion of their historic range. To conserve this species, wild-caught cottontails participate in a reintroduction breeding program. To increase the program’s productivity, this study described breeding behavior in pairings with (n = 3 pairings) and without (n = 9 pairings) reproductive success. Females were paired with two males consecutively and behaviors were recorded using 24 h continuous video footage. Activity peaked between 19:00 and 06:00. Copulation was only observed in successful pairings, and the gestation period was 31 days. Successful pairings had …

Characterization Of Antibody Repertoires Developed From Naive And Recall Responses, Nicholas C. Curtis

Dartmouth College Ph.D Dissertations

Adaptive immunity, comprised in part by the antibody repertoire, is the cornerstone of our ability to remain healthy amongst the plethora of pathogenic challenges we encounter daily. Despite the importance of understanding antibody repertoire development, much remains unknown about the composition and evolution of circulating antibodies in response to viral challenges. To better understand antibody repertoire development, we profiled the serum antibody repertoire using a combination of next-generation sequencing and serum antibody proteomics in the predominantly naïve response against SARS-CoV-2 spike and the recalled response to influenza hemagglutinin. The response to SARS-CoV-2 spike in four convalescent individuals was diverse (consisting …

Driving Cars Down Memory Lane: Uncovering Car Memory T Cell And Antigenspecific Endogenous T Cells Importance In Durable Responses Against Melanoma, Asmaa Mohamed

Dartmouth College Ph.D Dissertations

Responsiveness to chimeric antigen receptor (CAR) T cell therapy correlates with CAR T cell expansion and persistence in vivo. Multiple working strategies improve CAR T cell persistence by increasing stem-like properties or by sustaining CAR T cell activity with combination therapies. Herein, we describe the intrinsic ability of CAR T cells to differentiate into memory T cells, the effect of cytokine armoring, and neoadjuvant CD4 depletion therapy on CAR and tumor-specific endogenous memory T cells. TRP1-specific CAR T cells alone or in combination with Super2 + IL-33 (S233) armoring and/or CD4 depletion therapy were evaluated in the immunocompetent B16F10 melanoma …

Keunggulan Kompetitif Produk Pangan-Pertanian Asean-5 Selama 20 Tahun: Perubahannya Melalui Krisis, Reninta Dewi Nugraheni, Kanetasya Sabilla

Jurnal Ekonomi dan Pembangunan Indonesia

This study aims to assess the competitive advantage of foreign trade in agri-food products of five Association of South East Asia Nations (ASEAN) countries, namely Indonesia, Malaysia, Thailand, Singapore, and the Philippines between 2003–2022 by dividing the period into the global crisis in 2009, the trade war between China and the United States (US) in 2018, and the COVID-19 pandemic in 2020. The study built an econometric model using the Revealed Comparative Advantage (RCA) and Revealed Symmetric Comparative Advantage (RSCA) indicators. It was found that the value of the RSCA distribution for the five countries has changed significantly over the …

Redefining Nationalism And Patriotism In Iran And Azerbaijan: Exploring Fathali Akhundzade's Modernist Perspective, Muharrem Bagir

Khazar Journal of Humanities and Social Sciences

Fathali Akhundzade emerged as a preeminent figure among Muslim intellectuals and modernists of the nineteenth century, whose intellectual legacy profoundly impacted societies in Azerbaijan, Iran, and Turkey. For the first time, he proposed various concepts and ideas, including Islamic Protestantism, alphabet reform and modern education, as well as nationalism, ideas that are still controversial. Among his ideas, those regarding religion and patriotism have been more controversial than others, so that many scholars have offered conflicting interpretations of his ideas. For example, many in Iran consider him the founder of Persian nationalism, while others primarily in Azerbaijan and Turkey portray him …

Enhancing Green Sea Urchin (Strongylocentrotus Drobachiensis) Production Toward Sustainability, Tara Plee

Open Access Dissertations

The green sea urchin (Strongylocentrotus droebachiensis) fishery was once prosperous in the Gulf of Maine, peaking in the 1980s and early 1990s. However, since the early 1990s, the fishery has dramatically declined despite having harvesting restrictions. To sustain the industry, production through aquaculture is necessary, but hatchery production methods are not yet optimized, with settlement success and post-settlement survival as low as 1-5%, and the spatial scale for field grow-out may be limited in some regions due to climate change. Additionally, there are knowledge gaps in fishery management regarding whether oversized S. droebachiensis help sustain natural stocks. This …

The Battle Between Open Markets And National Security: How Limiting Investments Into Foreign Technology Might Be Hurting National Security Goals, Alexandra Van Cleef

Catholic University Journal of Law and Technology

No abstract provided.

State Barrier Fence - Esperance Extension Project Overview 2024, Department Of Primary Industries And Regional Development, Western Australia

Biosecurity published reports

Western Australia’s State Barrier Fence plays an important role in protecting landholders inside the fence by preventing the movement of animal pests, including wild dogs and emus, from pastoral areas into the agricultural regions. It is a state asset which is managed by the Department of Primary Industries and Regional Development.

The original fences (numbers 1, 2 and 3) were constructed between 1902 and 1907. Originally known as the Rabbit Proof Fences, it has also been known as the State Vermin Fence, the Emu Fence and now the State Barrier Fence. Since 2010, the fence has been upgraded to wild …

Wa Insecticide Guide 2024 - Winter Spring, Svetlana Micic, Alan Lord

PestFacts WA

The insecticides listed in the tables within this guide can be used on any crop appearing on the chemical label, if the rate used does not exceed the highest rate that is registered for use on that crop.

There are many products with different trade names that contain the same active ingredient. This list is not exhaustive and does not imply any specific recommendations of brand names.

Identification Des Bactéries Cultivables, Delphine Lanoie, Thi Thanh Tam Nguyen, Audrey Bernèche-D'Amours

Microbiologiques

Cette méthode est utilisée pour identifier des bactéries cultivées à partir d’échantillons d’air, de surface ou provenant de procédés solides ou liquides. Après avoir isolé une souche bactérienne en culture pure, les caractères macroscopiques et microscopiques des colonies bactériennes sont observés et des tests biochimiques simples sont réalisés. L’identification finale pourra être réalisée en utilisant une ou plusieurs de ces techniques : par spectrométrie de masse utilisant la technologie MALDI-ToF, par séquençage de type Sanger du gène codant pour l’ARNr 16S ou en fonction des caractéristiques phénotypiques de la souche par le système Biolog (tests biochimiques).

Abstract

This method is …

Identification Of Culturable Bacteria, Delphine Lanoie, Thi Thanh Tam Nguyen, Audrey Bernèche-D'Amours

Microbiologiques

Cette méthode est utilisée pour identifier des bactéries cultivées à partir d’échantillons d’air, de surface ou provenant de procédés solides ou liquides. Après avoir isolé une souche bactérienne en culture pure, les caractères macroscopiques et microscopiques des colonies bactériennes sont observés et des tests biochimiques simples sont réalisés. L’identification finale pourra être réalisée en utilisant une ou plusieurs de ces techniques : par spectrométrie de masse utilisant la technologie MALDI-ToF, par séquençage de type Sanger du gène codant pour l’ARNr 16S ou en fonction des caractéristiques phénotypiques de la souche par le système Biolog (tests biochimiques).

Abstract

This method is …

Project Portfolio: Spiritual Sexuality A Guidebook For Parents, Kelly Edmiston

Doctor of Ministry

In this project portfolio, I will address the following NPO: Christian parents of school-aged children don’t know what to teach their children about sex.

As the Lead Pastor of the Vineyard Church of Sugar Land/Stafford, I found that Christians lack integration between sexuality and spirituality. Kids and teens learn about sex from the media, and they learn about spirituality from parents and church. This led me to focus my project on an integration between the two. Spiritual sexuality is a guidebook for parents of school-aged children. In my research, I found that parents feel overwhelmed and ill-equipped to lead their …

Examining The Synergy Between The Marketplace And The Church In Ghana: Strategies For Enhancing Socio-Economic Development, Grace Opuni-Darko

Doctor of Ministry

This dissertation explores the complex relationship between the marketplace and Church in Ghana, seeking to identify collaborative strategies that lead to sustainable socio-economic development. The study aims to unravel the complexities of this relationship and identify effective strategies that can foster sustainable growth and development within the Ghanaian context. At the core of this research is an in-depth historical analysis, tracing the evolution of the Churches' role in the Ghanaian economy from colonial times to the present day. This historical perspective provides a critical backdrop for understanding current dynamics and trends. The study employs a multifaceted approach, incorporating both qualitative …

Inflammation And Tumor Progression: The Differential Impact Of Saa In Breast Cancer Models, Daniel Wilhelm Olivier, Carla Eksteen, Manisha Du Plessis, Louis De Jager, Lize Engelbrecht, Nathaniel Wade Mcgregor, Preetha Shridas, Frederick C. De Beer, Willem J. S. De Villiers, Etheresia Pretorius, Anna-Mart Engelbrecht

Saha Cardiovascular Research Center Faculty Publications

Background: Previous research has shown that the Serum Amyloid A (SAA) protein family is intricately involved in inflammatory signaling and various disease pathologies. We have previously demonstrated that SAA is associated with increased colitis disease severity and the promotion of tumorigenesis. However, the specific role of SAA proteins in breast cancer pathology remains unclear. Therefore, we investigated the role of systemic SAA1 and SAA2 (SAA1/2) in a triple-negative breast cancer mouse model.

Methods: Syngeneic breast tumors were established in wild-type mice, and mice lacking the SAA1/2 (SAADKO). Subsequently, tumor volume was monitored, species survival determined, the inflammatory profiles of mice …

The Effectiveness Of Constructed Treatment Wetland Systems At Removing Microplastic Pollution, Katherine L. Johnsen

Honors Undergraduate Theses

Plastics are a highly utilized material in modem society, leading to environmental concerns surrounding plastic pollution. Microplastics, which are defined as plastic particles less than 5mm in size, have additionally become increasingly recognized as a harmful pollutant in aquatic systems. Constructed treatment wetland systems (CTWSs) are highly effective at removal and mitigation of pollutants, including anthropogenic nutrient inputs. This study aims to understand the potential of a CTWS to remove microplastic pollution from tertiary-treated municipal wastewater before discharge into a local natural water body. Microplastic percent removal was determined through the manual quantification of microplastics in triplicate 500mL surface water …

The Influence Of Foster Parent Characteristics On The Relational Permanence Of Foster Youth, Yogita Venkata

Honors Undergraduate Theses

Research suggests that lack of permanency is associated with an increased risk of aggression, mental instability, and delinquent behavior in children (Leve et al., 2012). A crucial component of permanency involves establishing stable connections, including relational permanence with peers and adults, which are believed to enhance the well-being of foster youth (Wekerle et al., 2009). Further, the literature suggests a relationship between a parent’s adverse traumatic experiences, their attachments to their own parents, and their ability to regulate their foster child’s relational permanence to supportive adults and peers. Foster parents who have experienced trauma are often insecurely attached to their …

An In-Vitro Model For Visualizing Intraocular Lens And Lens Capsule Interaction In Posterior Capsule Opacification, Amjad Chatila

Bioengineering Dissertations - Archive

Posterior Capsule Opacification (PCO) is a common complication post cataract surgery. It is believed that Intraocular Lens (IOL) physical and chemical properties would affect their PCO potential. The tight binding between IOL and posterior lens capsule (PLC) is believed to have a negative impact on PCO formation, as suggested in the “No space, no cell, no PCO” hypothesis. To test the hypothesis, we have recently developed an in vitro 3D system to simulate IOL and PLC physical interaction. To expand the function and capability of this system, one objective of my work was to develop the next generation adhesion force …

Novel Engineering Approaches For Orthopedic Injury Treatment And Infection Diagnosis, Cynthia Co

Bioengineering Dissertations - Archive

Bioengineering has made significant contributions to the treatment of orthopedic injury through interdisciplinary approaches. Central to these advancements are many orthopedic implants, including anchors and joint replacements, which have been designed to restore mobility. Despite their functional efficacy, these products have limited lifespan and are associated with many complications, such as implant-associated infection. The success of implant design and function, both in the short and long term, is paramount for enhancing patient outcomes and overall well-being. Therefore, my thesis work is dedicated to addressing these critical challenges, aiming to maximize their treatment effect while minimizing the implant-associated complications.

Long-term patient …

Transient Interactions Modulate The Affinity Of Nf-Κb Transcription Factors For Dna, Tianjie Li, Shandy Shahabi, Tapan Biswas, Oleg V. Tsodikov, Wenfei Pan, De-Bin Huang, Vivien Ya-Fan Wang, Yi Wang, Gourisankar Ghosh

Biology Faculty Publications

The dimeric nuclear factor kappa B (NF- κB) transcription factors (TFs) regulate gene expression by binding to a variety of κB DNA elements with conserved G:C-rich flanking sequences enclosing a degenerate central region. Toward defining mechanistic principles of affinity regulated by degeneracy, we observed an unusual dependence of the affinity of RelA on the identity of the central base pair, which appears to be noncontacted in the complex crystal structures. The affinity of κB sites with A or T at the central position is ~10- fold higher than with G or C. The crystal structures of neither the complexes nor …

The Guardian The Month Of January 2024, Wright State Student Body

The Guardian Student Newspaper

News articles from The Guardian for the Month of January 2024. The Guardian is the official student-run newspaper for Wright State University. It has been published regularly since March of 1965.

Single-Component Hydrophilic Terpolymer Thin Film Systems For Imparting Surface Chemical Versatility On Various Substrates, Yun Hee Ko, Hai Ha Tran Nguyen, Christopher R. Branstetter, Soeun Park, Jin Kyun Lee, Jaesung Yang, Jangwook P. Jung, Myungwoong Kim

Faculty Publications

We demonstrate a single-component hydrophilic photocrosslinkable copolymer system that incorporates all critical functionalities into one chain. This design allows for the creation of uniform functional organic coatings on a variety of substrates. The copolymers were composed of a poly(ethylene oxide)-containing monomer, a monomer that can release a primary amine upon UV light, and a monomer with reactive epoxide or cyclic dithiocarbonate with a primary amine. These copolymers are easily incorporated into the solution-casting process using polar solvents. Furthermore, the resulting coating can be readily stabilized through UV light-induced crosslinking, providing an advantage for controlling the surface properties of various substrates. …

Method For Assessing Coating Uniformity Of Angioplasty Balloons Coated With Poly(Lactic-Co-Glycolic Acid) Nanoparticles Loaded With Quercetin, Allison D. Zieschang, Kevin F. Hoffseth, Tammy R. Dugas, Carlos E. Astete, Dorin Boldor

Faculty Publications

In this study, we aim to quantify coating uniformity and correlate fluorescence intensity to drug loading for drug-coated angioplasty balloons (DCB) coated with 5, 10, 15, or 20 layers of poly(lactic-co-glycolic acid) nanoparticles (NPs) entrapped with quercetin. Uniformity was quantified from histograms and horizontal line profiles of microscopic fluorescent images acquired with sample specific parameters, and cracks in the coating were measured and counted. The fluorescence of images acquired with global parameters was correlated with quercetin loading measured via gravimetric/HPLC analysis. More layers on DCBs may be associated with less uniform coatings, as indicated by differences in histogram standard deviations. …