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2024

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Transnationalizing Feminist Translation Studies? Insights From The Warwick School Of Feminist Translation: A Roundtable, Olga Castro, Emek Ergun, Maud Anne Bracke, William J. Spurlin, Luciana Carvalho Fonseca Jan 2024

Transnationalizing Feminist Translation Studies? Insights From The Warwick School Of Feminist Translation: A Roundtable, Olga Castro, Emek Ergun, Maud Anne Bracke, William J. Spurlin, Luciana Carvalho Fonseca

Journal of Feminist Scholarship

This roundtable article features a conversation among the five scholars who delivered keynotes at the Warwick School of Feminist Translation, held at the University of Warwick, UK, in May 2023: Olga Castro, Emek Ergun, Maud Anne Bracke, William J. Spurlin, and Luciana Carvalho Fonseca. Drawing on their uniquely interdisciplinary expertise on the politics of translation and interpreting, the authors explore the urgent role that translation and translators, as well as the fields and scholars of feminist and queer translation and interpretation studies, play in distrupting and dismantling heteropatriarchal, racist, homonationalist, and colonial regimes of power. Their conversations reveal the urgent …


We Shall Overcome: The Evolution Of Quotas In The Land Of The Free And The Home Of Samba, Stella Emery Santana Jan 2024

We Shall Overcome: The Evolution Of Quotas In The Land Of The Free And The Home Of Samba, Stella Emery Santana

Seattle University Law Review

When were voices given to the voiceless? When will education be permitted to all? When will we need to protest no more? It’s the twenty-first century, and the fight for equity in higher education remains a challenge to peoples all over the world. While students in the United States must deal with the increase in loans, in Brazil, only around 20% of youth between the ages of twenty-five and thirty-four have a higher education degree.

The primary objective of this Article is to conduct an in-depth comparative analysis of the development, implementation, and legal adjudication of educational quota systems within …


Pacific Islands And The U.S. Military: The Legal Borderlands Of The Environmental Movement, Sonia Lei Jan 2024

Pacific Islands And The U.S. Military: The Legal Borderlands Of The Environmental Movement, Sonia Lei

Seattle University Law Review

Climate change remains an urgent, ongoing global issue that requires critical examination of institutional polluters. This includes the world’s largest institutional consumer of petroleum: the United States military. The Department of Defense (DoD) is a massive institution with little oversight, a carbon footprint spanning the globe, a budget greater than the next ten largest nations combined, and overly generous exemptions to environmental regulations and carbon reduction targets. This Comment examines how this lack of accountability and oversight plays out in the context of three Pacific islands that have hosted U.S. military bases for decades. By considering the environmental impact of …


Musical Reward In Young Children, Haley E. Kragness, Kendra Mehl, Amy M. Belfi Jan 2024

Musical Reward In Young Children, Haley E. Kragness, Kendra Mehl, Amy M. Belfi

Psychological Science Faculty Research & Creative Works

Musical pleasure stems from an interplay of social, emotional, and cognitive factors. In adults, there are large individual differences in musical reward, with some individuals (deemed "hyperhedonic" to music) reporting very high reward and others (deemed "anhedonic" to music) reporting very low reward. Musical anhedonia is, therefore, a selective lack of pleasure in response to music, defined by self-reported low musical reward in the absence of generalized anhedonia. While this phenomenon has been investigated in adults in recent years, little is known about musical anhedonia or musical reward more generally in children. To address this, we investigated parents' perceptions of …


Western Boundary Current-Subtropical Continental Shelf Interactions, William B. Savidge, Dana K. Savidge, Frederico Brandini, Adam T. Greer, Eileen E. Hofmann, Moninya Roughan, Iison De Silvera, Iain M. Suthers Jan 2024

Western Boundary Current-Subtropical Continental Shelf Interactions, William B. Savidge, Dana K. Savidge, Frederico Brandini, Adam T. Greer, Eileen E. Hofmann, Moninya Roughan, Iison De Silvera, Iain M. Suthers

CCPO Publications

Western boundary currents (WBCs) adjacent to subtropical continental shelves (STCSs; between ~25° and 35° latitude; Figure 1) transport heat, nutrients, and biota poleward along the western margins of major ocean basins, interacting with the continental margins and influencing their physics and biology. Eddies and meanders along the shelf edge upwell deep, nutrient-laden water that can be advected onto the adjacent shelves with a corresponding export of particle-rich shelf water (e.g., Lee et al., 1991; Kimura et al., 1997; Campos et al., 2000; Roughan and Middleton, 2002, 2004; Lutjeharms, 2006; Savidge and Savidge, 2014). Despite their similarities, the various STCS regions …


Building A Coordinated Framework For Research And Monitoring In Large-Scale International Marine Protected Areas: The Ross Sea Region As A Model System, Cassandra Brooks, Sharon Stammerjohn, Grant Ballard, Alice K. Duvivier, Eileen Hofmann, Michelle Larue, Cara Nissen, Alexander J. Orona, B. Jack Pan, Annie E. Schmidt, Nathan Walker, George M. Watters, John Weller Jan 2024

Building A Coordinated Framework For Research And Monitoring In Large-Scale International Marine Protected Areas: The Ross Sea Region As A Model System, Cassandra Brooks, Sharon Stammerjohn, Grant Ballard, Alice K. Duvivier, Eileen Hofmann, Michelle Larue, Cara Nissen, Alexander J. Orona, B. Jack Pan, Annie E. Schmidt, Nathan Walker, George M. Watters, John Weller

CCPO Publications

To fulfill their conservation potential and provide safeguards for biodiversity, marine protected areas (MPAs) need coordinated research and monitoring for informed management through effective evaluation of ecosystem dynamics. However, coordination is challenging, often due to knowledge gaps caused by inadequate access to data and resources, compounded by insufficient communication between scientists and managers. We propose to use the world's largest MPA in the Ross Sea, Antarctica as a model system to create a comprehensive framework for an interdisciplinary network supporting research and monitoring that could be implemented in other remote large-scale international MPAs. Our proposed framework has three key components: …


Pices At 32: An External Review, Eileen E. Hofmann, David Checkley, Fangli Qiao, Jörn Schmidt, Sinjae Yoo Jan 2024

Pices At 32: An External Review, Eileen E. Hofmann, David Checkley, Fangli Qiao, Jörn Schmidt, Sinjae Yoo

CCPO Publications

[Introduction] The North Pacific Marine Science Organization (Pacific ICES, PICES) has been an effective voice and proponent for North Pacific marine science for more than 30 years. During this time, PICES has provided a safe and active venue for the open exchange of science, developed an international science network that includes participants from academic and government institutions, and non- and inter-governmental organizations, and has taken on leadership roles in studying North Pacific ecosystems.


(Another) Introduction: Translating Transnational Feminisms, Erin Katherine Krafft, Caroline De Souza Jan 2024

(Another) Introduction: Translating Transnational Feminisms, Erin Katherine Krafft, Caroline De Souza

Journal of Feminist Scholarship

In this introduction to part two of the special issue “Translating Transnational Feminisms,” we examine the position of feminist translation practices and the theories of Feminist Translation Studies within transnational cultural and geopolitical contexts. We again explore translation as a core component of transnational feminist solidarities, focusing particularly on Feminist Translation Studies (FTS) as containing frameworks that allow for forms of and approaches to analysis that, due to the multidisciplinarity of the field, offer sight and insights that are unique in their depth and breadth.


Two Decades Of Gender Troubles In Iceland: The Translation Of Gender, Differences, And The Uncertainty Of Meaning, Katrín Harðardóttir Jan 2024

Two Decades Of Gender Troubles In Iceland: The Translation Of Gender, Differences, And The Uncertainty Of Meaning, Katrín Harðardóttir

Journal of Feminist Scholarship

When “gender” was translated to Icelandic in 1998 as kyngervi, the notion of performative gender had been circulating in Icelandic academia for a little over a year. The introduction and dissemination of the term inside academia then became quite rapid, with the help of diverse professional fields such as art, literary, history and gender studies, but criticism on the translation did not appear until well into the second decade of the twenty-first century, when it was pointed out that the translated term conveys a difference between “sex” and “gender,” with the possible consequence of perpetuating this dichotomy although it …


Shifting Shapes: Transnational Tactics Of The Authoritarian Right In Brazil And Russia, Erin Katherine Krafft, Caroline De Souza Jan 2024

Shifting Shapes: Transnational Tactics Of The Authoritarian Right In Brazil And Russia, Erin Katherine Krafft, Caroline De Souza

Journal of Feminist Scholarship

Global right-wing anti-gender movements have developed a transnational pattern in their uses of language as a means of subjugation and of control, and this article examines manifestations of this pattern in two specific states: Brazil and Russia. By exploring the anti-gender languaging, rhetoric, and legislation advanced by Jair Bolsonaro (President of Brazil 2019–2022) and Vladimir Putin (President of Russia 2000–2008 and 2012 to the present) and their supporters, we find that, in both contexts, anti-gender campaigns are reactions to and also drivers for increasingly dramatic political and social conflicts, and in each case, anti-gender ideologies are embedded in larger right-wing …


What Does 8th Grade Really Teach You, Parker Pierson Jan 2024

What Does 8th Grade Really Teach You, Parker Pierson

Celebrating Writers and Writing in our Communities

No abstract provided.


Jane Aronson, Aliyah Machado Jan 2024

Jane Aronson, Aliyah Machado

Celebrating Writers and Writing in our Communities

No abstract provided.


Azospirillum Brasilense Inoculation In A Maize–Urochloa–Rice Cropping System Promotes Soil Chemical And Biological Changes And Increases Productivity, Philippe Solano Toledo Silva, Nayara Siviero Garcia, Fernando Shintate Galindo, Orivaldo Arf, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Sharma, Ana Maria Rodrigues Cassiolato Jan 2024

Azospirillum Brasilense Inoculation In A Maize–Urochloa–Rice Cropping System Promotes Soil Chemical And Biological Changes And Increases Productivity, Philippe Solano Toledo Silva, Nayara Siviero Garcia, Fernando Shintate Galindo, Orivaldo Arf, Thiago Assis Rodrigues Nogueira, Arun Dilipkumar Sharma, Ana Maria Rodrigues Cassiolato

Biology, Agriculture and Chemistry Faculty Publications and Presentations

Large quantities of cover crop residues in the soil, combined, or not, with the inoculation of seeds with diazotrophic bacteria, can increase organic matter (OM) and protect soil microorganisms, such as arbuscular mycorrhizal fungi (AMF) and dark septate endophytic (DSE) fungi. Thus, the use of these sustainable biotechnologies can benefit microbial interactions, soil fertility and rice production in the Brazilian Cerrado region. In this study, we evaluated the effects of maize and Urochloa ruziziensis, intercropped or individually, as cover crops and an inoculation of Azospirillum brasilense on the chemical (fertility) and biological (C–microbial biomass and C–CO2 released) attributes of soil …


Navigating The Nuclear Horizon: Japan’S Yin-Yang Duality In Threshold Statesmanship, Prachi Lokhande Jan 2024

Navigating The Nuclear Horizon: Japan’S Yin-Yang Duality In Threshold Statesmanship, Prachi Lokhande

Journal of Strategic Security

The discourse concerning global nuclear issues amidst the escalation of geopolitical crises, particularly the Russia-Ukraine conflict, underscores the complex and multifaceted nature of nuclear dilemmas. The perception that nuclear weapons are indispensable for assuring survival in an unstable international environment generates increased concern. Aggression or the threat to the existence of a nation may motivate nations to construct nuclear arsenals. As a result of discontent with existing non-proliferation mechanisms and the conviction that proliferation is inevitable, discussions concerning nuclear alternatives are propelled. Diverse considerations, including security, prestige, and politics, motivate nuclear pursuits. Probing the nuclear intentions of states is a …


The Role Of Caregiver Anxiety, Sleep, Distress, And Emotion Socialization Behaviors On Child Behaviors, Amanda Hicks Jan 2024

The Role Of Caregiver Anxiety, Sleep, Distress, And Emotion Socialization Behaviors On Child Behaviors, Amanda Hicks

Master's Theses and Doctoral Dissertations

In early childhood, caregivers are the primary agents of emotion socialization, helping their child identify, label, and healthily express their emotions. How a caregiver aids in emotion development and understanding has important implications for their child’s behavior regulation. Distressed caregivers may have difficulty helping their child cope with negative emotions leading to an increased likelihood of problem behaviors over time. While some literature has highlighted an association between caregiver anxiety and child behavior problems, little is known about the mechanisms by which anxiety negatively impacts child behaviors. Caregiver risk factors such as poor sleep, distress related to their child’s negative …


Ungrading In The Music Theory Classroom: A One-Year Case Study, David E. Orvek Jan 2024

Ungrading In The Music Theory Classroom: A One-Year Case Study, David E. Orvek

Journal of Music Theory Pedagogy

In this paper, I present a summary of and critical reflection upon an alternative assessment practice known as “ungrading” that I used during the 2023–24 academic year. My version of the practice involved providing students with feedback without grades and letting students determine their own final grades through a process of guided self-assessment. Many students’ reactions to ungrading were positive. Some reported being able to focus on learning rather than grades, and even skeptical students admitted some benefits. Ungrading benefited me in various ways as a teacher, but there were challenges as well. Some students struggled with the lack of …


Book Review, Mia Swart, On Bonifratròw Street: How A Boy From Lwów Escaped The Nazis (2024), Mark A. Drumbl Jan 2024

Book Review, Mia Swart, On Bonifratròw Street: How A Boy From Lwów Escaped The Nazis (2024), Mark A. Drumbl

Scholarly Articles

On Bonifratròw Street is a book about biography, history, and law. It begins with Katz’s childhood in Lwów, Poland, before World War II. The story unwraps the backgrounds of his parents and other family members, notably his biological father, whose presence and then absence loom large in his life. The book then moves to the war. It details Katz’s life in a variety of places, including Lodz and Warsaw, among others, seen from his perspective as a teenager at the time. The book ends with Katz’s post-war emigration to the US, where he joined a distant relative. Defying odds and …


The 3rs And Non-Human Animals In Biomedical Research: The Next 65 Years, Paul Locke, Richelle Romanchik, Breanne Kincaid, Emily Golden Jan 2024

The 3rs And Non-Human Animals In Biomedical Research: The Next 65 Years, Paul Locke, Richelle Romanchik, Breanne Kincaid, Emily Golden

Animal Law Review

It has been 65 years since the publication of Russell and Burch’s “The Principles of Humane Experimental Technique,” which established the ‘3Rs’—refinement, reduction, and replacement—as the key principles applicable to decision making about, and the use of, non-human animals in laboratory settings. The 3Rs are universally accepted by responsible scientists throughout the world and form the basis for many national legal and regulatory systems governing animal use in laboratories. This Article will discuss broadly how the 3Rs have evolved over the past seven decades since the publication of Russell and Burch’s seminal work, and examine the 3Rs in light of …


Alchemizing The Bar: An Examination Of Global Ethical Considerations For Using Alternatives To Animals In Research, Testing, And Education, Lenore M. Montanaro Jan 2024

Alchemizing The Bar: An Examination Of Global Ethical Considerations For Using Alternatives To Animals In Research, Testing, And Education, Lenore M. Montanaro

Animal Law Review

Countries regulate scientific research in various ways. Such structures are the result of input from scientists, attorneys, physicians, advocates, and others. These schemes may also derive from outcomes of the research itself. Some countries do not incorporate or require the ethical use of an animal—or an alternative to the use of an animal—to be considered. Others do incorporate, and even require, the ethical use of animals in research. In alignment with The Three Rs—replacement, reduction, and refinement of animals used in science—technological capabilities now allow scientists to increasingly use alternatives, such as microphysiological systems, rather than animal models. This Article …


Confessions And Quantum Uncertainties: The Violence Of Language, Organismic Cells, And The Incarnation Of Words, Nahanni Freeman Jan 2024

Confessions And Quantum Uncertainties: The Violence Of Language, Organismic Cells, And The Incarnation Of Words, Nahanni Freeman

Faculty Publications - Psychology Department

This chapter will seek to examine language in its many permutations, including its inculcation from sociocultural, religious and historical forces, and its emergence within a developmental context that includes interiorization into private speech. The limitations of language for simulating the mind of the Other, the distance between minds, and the constant dynamism of words will be evaluated in light of the theme of the value of recognizing subjectivity and acknowledging layers of meaning in the quest for truth and legitimacy. Metaphors of the body are used to represent ecological and systemic forces in language, also emphasizing the potency of mind-word-body …


Adultery Provisions In Matrimonial Agreements, Elizabeth R. Carter Jan 2024

Adultery Provisions In Matrimonial Agreements, Elizabeth R. Carter

American University Law Review

Can a contract discourage your spouse from cheating or compensate you for a broken heart? Adultery penalties in marriage contracts seek to do exactly that. An adultery penalty is a financial penalty in a marriage contract triggered by a spouse’s infidelity. While many practitioners advise clients against adultery provisions in marriage contracts, some clients demand them. However, are adultery provisions enforceable? Should they be? This Article considers the sociolegal history of adultery and provides new insight into the enforceability and wisdom of adultery penalties. This Article also provides novel arguments that adultery provisions should not be enforced and calls upon …


Investigating Tuberculosis Dynamics Using Surveillance Data And Statistical Modeling: Studies In Three High Burden Settings, Melanie Hunter Chitwood Jan 2024

Investigating Tuberculosis Dynamics Using Surveillance Data And Statistical Modeling: Studies In Three High Burden Settings, Melanie Hunter Chitwood

Yale Graduate School of Arts and Sciences Dissertations

Tuberculosis (TB) is a leading cause of death from infectious disease globally, despite the availability of effective antibiotic treatment. Control efforts focus on the rapid diagnosis and treatment of individuals with TB, which reduces both disease-related morbidity and mortality and onward transmission. In addition to passive case finding, the World Health Organization recommends active case finding for high-risk individuals and their contacts. Expanding these activities to populations in which there is evidence of recent transmission may be a suitable strategy to reduce TB burden, but identifying these populations is a persistent challenge. Statistical analyses, informed by high quality surveillance data, …


Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel Jan 2024

Pulse-Width Modulation Spray System Performance And Development Of A Novel System To Optimize Spray Use Efficacy, Prashanta Pokharel

Theses and Dissertations--Biosystems and Agricultural Engineering

The overarching objective of this research was to enhance our understanding of pulse width modulation (PWM) based nozzle control system and develop an intelligent nozzle control system for agricultural spray applications. This dissertation focused on measuring and analyzing the transient nozzle pressure characteristics and performance under PWM control. Additionally, it explored the development of an innovative multi-degree-of-freedom (DOF) nozzle control system for precise chemical applications in specialty crop systems.

The pressure dynamics of a PWM system were studied by developing an instrumentation system capable of operating a solenoid valve and recording pressure signals. A nozzle body and two manifolds of …


A Class Of Game-Theoretic And Fokker-Planck Optimal Control Frameworks In Colon And Esophageal Cancer, Mesfer Alajmi Phd Jan 2024

A Class Of Game-Theoretic And Fokker-Planck Optimal Control Frameworks In Colon And Esophageal Cancer, Mesfer Alajmi Phd

Mathematics Dissertations - Archive

In this dissertation, we first present a new stochastic framework for parameter estimation and uncertainty quantification in colon cancer-induced immune responses. A stochastic process that captures the system's inherent randomness determines the dynamics of colon cancer. The stochastic framework is based on the Fokker-Planck equation, which represents the evolution of the probability density function corresponding to the stochastic process. We formulate an optimization problem that takes individual patient data with randomness present and solves it to obtain the unknown parameters corresponding to the individual tumor characteristics. Furthermore, we perform a sensitivity analysis of the optimal parameter set to identify the …


Batch Culture Models Of The Murine Gut Microbiome & The Impact Of Simple Dormancy On Dormancy-Capable Microorganisms Models, Ana C. Mendez Jan 2024

Batch Culture Models Of The Murine Gut Microbiome & The Impact Of Simple Dormancy On Dormancy-Capable Microorganisms Models, Ana C. Mendez

Mathematics Dissertations - Archive

The proposed mathematical biology research utilizes mathematical models to gain insight into biological systems. These systems of ordinary differential equations model diverse topics, ranging from gut microbiomes to harmful algal blooms. A complete stability analysis, supporting phase plane portraits, bifurcation diagrams, and numerical simulations will accompany the models presented. In Chapter 2, the murine gut microbiome is modeled to match laboratory experiments in the literature. In these experiments, mice eat plasmid-carrying “donor” bacteria and naturally carry plasmid-free “resident” bacteria in their gut. The models aim to capture the behavior of plasmids, donor bacteria, and resident bacteria. Chapter 3 explores dormancy …


College Of Computing And Engineering Graduate Catalog 2024-2025, Nova Southeastern University Jan 2024

College Of Computing And Engineering Graduate Catalog 2024-2025, Nova Southeastern University

College of Psychological Services / College of Psychology Postgraduate Student and Course Catalogs

No abstract provided.


Computational Study Of Proton Transfer At Transition Metal Hydrides, Megan Ford Jan 2024

Computational Study Of Proton Transfer At Transition Metal Hydrides, Megan Ford

Honors Theses

Energy storage in the bonds of common chemical feedstocks is an attractive solution to the unreliability of wind and solar power due to its long term efficiency and easy recoverability. Energy is stored by reducing chemicals like ammonia, formic acid, and hydrogen, the reaction of which is dependent on a catalyst. To catalyze the reaction, the catalyst undergoes a slow proton transfer (PT) step to form what is known as a metal hydride. The sluggish kinetics of this step lower the effectiveness of the catalyst, and therefore must be better understood in order to improve the efficiency of energy storage …


How We Make It: Disability Justice, Autoimmunity, Community, A Multimedia Project, Alexandra Juhasz, How We Make It Collective Jan 2024

How We Make It: Disability Justice, Autoimmunity, Community, A Multimedia Project, Alexandra Juhasz, How We Make It Collective

Publications and Research

How We Make It: Disability Justice, Autoimmunity, Community is a born-digital multimedia piece that lives on the Scalar platform and that was submitted and eventually accepted into the Special Section on Autoimmunities in the Wake of COVID-19. The text below is a close reproduction of the Navigation page within the Scalar piece. While reading this text, one cracks open the door to glimpse the ten-person collective behind this project.


Novel Spirocyclic Dimer, Spid3, Targets Chronic Lymphocytic Leukemia Survival Pathways With Potent Preclinical Effects, Alexandria Eiken, Audrey L. Smith, Sydney A. Skupa, Elizabeth Schmitz, Sandeep Rana, Sarbjit Singh, Siddhartha Kumar, Jayapal Reddy Mallareddy, Aguirre A. De Cubas, Akshay Krishna, Achyuth Kalluchi, M. Jordan Rowley, Christopher R. D'Angelo, Matthew A. Lunning, Gregory Bociek, Julie M. Vose, Amarnath Natarajan, Dalia El-Gamal Jan 2024

Novel Spirocyclic Dimer, Spid3, Targets Chronic Lymphocytic Leukemia Survival Pathways With Potent Preclinical Effects, Alexandria Eiken, Audrey L. Smith, Sydney A. Skupa, Elizabeth Schmitz, Sandeep Rana, Sarbjit Singh, Siddhartha Kumar, Jayapal Reddy Mallareddy, Aguirre A. De Cubas, Akshay Krishna, Achyuth Kalluchi, M. Jordan Rowley, Christopher R. D'Angelo, Matthew A. Lunning, Gregory Bociek, Julie M. Vose, Amarnath Natarajan, Dalia El-Gamal

Journal Articles: Oncology and Hematology

Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NFκB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacologic agents that induce accumulation of misfolded proteins. Frontline CLL therapeutics that directly target BCR signaling such as Bruton tyrosine kinase (BTK) inhibitors (e.g., ibrutinib) have enhanced patient survival. However, resistance mechanisms wherein tumor cells bypass BTK inhibition through acquired BTK mutations, and/or activation of alternative survival …


Myc Overexpression In Natural Killer Cell Lymphoma: Prognostic And Therapeutic Implications, Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, Kai Fu Jan 2024

Myc Overexpression In Natural Killer Cell Lymphoma: Prognostic And Therapeutic Implications, Chengfeng Bi, Yuhua Huang, Roshia Ali, Fang Wang, Xia Yang, Alyssa Bouska, Lu Xu, Xinbao Hao, Matthew A. Lunning, Wing C. Chan, Javeed Iqbal, Dennis D. Weisenburger, Julie M. Vose, Kai Fu

Journal Articles: Oncology and Hematology

The current clinical management of extranodal natural killer (NK)/T-cell lymphoma (ENKTL) primarily depends on conventional chemotherapy and radiotherapy, underscoring the need for innovative therapeutic strategies. This study explores the clinical significance and therapeutic implication of c-MYC (MYC) in ENKTL. Initially, we identified MYC protein overexpression in approximately 75% of cases within a large cohort of 111 patients. MYC overexpression was strongly correlated with lymphoma cell proliferation and poor clinical outcomes. Intriguingly, integrating MYC expression into the prognostic index of NK cells lymphoma with Epstein-Barr virus (PINK-E) prognostic model significantly enhanced its predictive power. Subsequently, we implemented MYC knockdown in NK …