Digital Commons Network^™

Sod1 Is A Synthetic Lethal Target In Ppm1d-Mutant Leukemia Cells, Linda Zhang, Joanne I Hsu, Etienne D Braekeleer, Chun-Wei Chen, Tajhal D Patel, Alejandra G Martell, Anna G Guzman, Katharina Wohlan, Sarah M Waldvogel, Hidetaka Urya, Ayala Tovy, Elsa Callen, Rebecca Murdaugh, Rosemary Richard, Sandra Jansen, Lisenka Vissers, Bert B A De Vries, Andre Nussenzweig, Shixia Huang, Cristian Coarfa, Jamie N Anastas, Koichi Takahashi, George Vassiliou, Margaret A Goodell

Faculty, Staff and Students Publications

The DNA damage response is critical for maintaining genome integrity and is commonly disrupted in the development of cancer. PPM1D (protein phosphatase, Mg2+/Mn2+ dependent 1D) is a master negative regulator of the response; gain-of-function mutations and amplifications of PPM1D are found across several human cancers making it a relevant pharmacologic target. Here, we used CRISPR/Cas9 screening to identify synthetic-lethal dependencies of PPM1D, uncovering superoxide dismutase-1 (SOD1) as a potential target for PPM1D-mutant cells. We revealed a dysregulated redox landscape characterized by elevated levels of reactive oxygen species and a compromised response to oxidative stress in PPM1D-mutant cells. Altogether, our …

Prevalence Of Entamoeba Histolytica Among Patients Attending Al-Zubair General Hospital In Basra Province /Iraq, Sarah Naser

Al-Ameed Journal for Medical Research and Health Sciences

Background: Besides malaria and schistosomiasis, Entamoeba histolytica the most important sources of illness and death in humans worldwide. The prevalence of E. histolytica in Basra province has received little research and it is critical in Basra city to identify and manage the risk factors connected to the parasite.

Aims: The objective of this research is to provide insight into the prevalence of amoebiasis among patients who attended Al-Zubair General Hospital during period 2020, 2021 and 2022.

Procedure: For the purpose of to detect and diagnose E. histolytica infection, (2,145) stool samples from patients attending Al-Zubair General Hospital in Basra province/ …

Study A Relationship Between Age, Body Mass Index, And Sperm Parameters With Sperm Dna Fragmentation Levels In Iraqi Infertile Patients, Talal Z. Al-Darawsha, Nurten Dayioglu, Bushra R. Al-Azzawi, Tulay Irez

Al-Ameed Journal for Medical Research and Health Sciences

Background: Male infertility is complex and accounts for approximately 50% of couples facing conception challenges. Factors such as body mass index, age, and sperm parameters play significant roles. Recognizing their impact is vital for diagnosis and treatment. Aim of the study: The study aimed to evaluate DNA integrity in individuals with unexplained infertility and assess its correlation with age, body mass index, and semen parameters. Materials and Methods: In this study, 111 males who met the inclusion criteria were recruited for our study. Selected participants were grouped according to their age, body mass index, and semen parameters, including (sperm count, …

Genetically Caused Oral Disorders: Pathogenesis And Treatment: A Review, Ali Alsuraifi, Abdullah Ayad, Yousif Husam, Noor Alhuda R. Mohammed, Fatimah H. Mahdi, Jassem Mohammed, Zainab M. Sulaiman, Sarah Kareem

Al-Ameed Journal for Medical Research and Health Sciences

The mouth is a unique and intricate structure composed of various anatomical components that work together effectively to perform various functions. The oral cavity can be affected by various disorders, such as genetic diseases, infections, and metabolic disorders. A wide range of genetic disorders can affect the skeletal system, including craniofacial structures and teeth. These disorders exhibit a significant variety in terms of their causes when they show up, and how severe they are. Genetics is a significant risk factor in the development of oral diseases. It affects the pattern of inheritance, which can be dominant, recessive, or both. The …

Testosterone Hormone ; Clinical Indications, Dysregulation And Therapeutic Methods, Talal Z. Al-Darawsha

Al-Ameed Journal for Medical Research and Health Sciences

Testosterone is a hormone primarily produced by the testicles in adult men and it is the basic male sex hormone and an anabolic steroid. Androgen is important for survival. It is influences a man's appearance and sexual development, stimulating sperm production and regulating sex drive. This hormone is a key growth factor in prostate gland. Prostatic cells stop thriving when testosterone levels fall and Prostate cancer cells shrink both benign and malignant. Testosterone deficiency is a clinical and biochemical syndrome that is linked to ageing and is characterized by typical symptoms and a testosterone deficiency in the blood. The number …

Clinical Management Of Larsen Syndrome In Inpatient Rehabilitation: A Case Report, Philippe J. Dentino

Research Symposium

Background: Larsen Syndrome is a rare osteochondrodysplasic disorder associated with Filamin 1 (FLN) gene mutations and clinically presents with frequent large joint dislocations, osseous disturbances, and craniofacial abnormalities. To date, no studies have assessed the medical and rehabilitative management of an individual living with Larsen Syndrome in an inpatient rehabilitation care setting.

Case Presentation: A 30 year-old biological female presented to the emergency department after developing worsening right-sided low back pain while bending forward. The patient’s past medical and surgical history was significant for Larsen Syndrome complicated by chronic hip, knee, and back pain, Celiac disease, major depressive disorder, post-traumatic …

What Is Task-Oriented Training? A Scoping Review, Erin Halford, Samantha Jakubiszak, Kassidy Krug, Amanda Umphress

Student Journal of Occupational Therapy

Task-Oriented Training (TOT) is an proven stroke rehabilitation intervention with significant evidence-based research that supports its effectiveness. The absence of a clear definition has led to variability in research reporting and subsequent confusion with practical implementation. A consistent definition seeks to remedy this ambiguity to facilitate knowledge translation. The objective of this study was to determine a comprehensive definition of TOT that encapsulates previous definitions and descriptions in the literature. In order to derive this definition, a two stage scoping review process was conducted across four databases searching for articles on the use of TOT in adult stroke rehabilitation therapy. …

Cloran Hodges Stewart

African American Funeral Programs

No abstract provided.

Cas Connections- 2024 Spring Term - January, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Winona State University Academics Blog: 2011-2024, Winona State University

Winona State University Blogs

The Winona State University (WSU) Academic Blog inlcudes articles and entries from May 2011- January 2024. Note: there may be format coding in the document.

Biographical Memoirs: Napoleon A. Chagnon, Raymond B. Hames

Department of Anthropology: Faculty Publications

Napoleon A. Chagnon (August 27, 1938–September 21, 2019), elected to the National Academy of Science in 2012. A Biographical Memoir by Raymond B. Hames, University of Nebraska-Lincoln.

Chagnon was a Renaissance anthropologist who made numerous fundamental contributions to anthropology. His films and ethnography have been viewed by millions around the world. He combined a humanistic eye in research with an unwavering scientific approach to human culture and behavior. He set multiple standards for long-term field research in terms of methodological rigor and refinement. He made some of the first tests of inclusive fitness theory in human behavior. And he was …

Electron Effective Mass In Gan Revisited: New Insights From Terahertz And Mid-Infrared Optical Hall Effect, Nerijus Armakavicius, Sean Knight, Philipp Kühne, Vallery Stanishev, Dat Q. Tran, Steffen Richter, Alexis Papamichail, Megan Stokey, Preston Sorensen, Ufuk Kilic, Mathias Schubert, Plamen P. Paskov, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Electron effective mass is a fundamental material parameter defining the free charge carrier transport properties, but it is very challenging to be experimentally determined at high temperatures relevant to device operation. In this work, we obtain the electron effective mass parameters in a Si-doped GaN bulk substrate and epitaxial layers from terahertz (THz) and mid-infrared (MIR) optical Hall effect (OHE) measurements in the temperature range of 38–340 K. The OHE data are analyzed using the well-accepted Drude model to account for the free charge carrier contributions. A strong temperature dependence of the electron effective mass parameter in both bulk and …

Broadscale Coral Disease Interventions Elicit Efficiencies In Endemic Disease Response, Kathryn A. Toth, Samantha F. Buckley, Hunter Noren, Karen L. Neely, Brian K. Walker

Marine & Environmental Sciences Faculty Articles

The presence and abundance of reef-building corals are crucial to the long-term existence of Caribbean coral reef ecosystems, providing both direct and indirect, local and global, ecological, economic, and social benefits. In 2014, stony coral tissue loss disease (SCTLD) was first identified in southeast Florida and remains endemic to the region, while continuing to spread throughout the Caribbean. Effective in situ intervention treatments using antibiotic paste can halt lesion progression on Montastraea cavernosa up to 90% of the time. This study investigated intervention activities over a three-year period to identify efficiencies in disease response. Since May 2019, 1,037 corals, >85% …

The Relationship Between The Saharan Air Layer, Convective Environmental Conditions, And Precipitation In Puerto Rico, P. W. Miller, C. Ramseyer

Faculty Publications

The Saharan Air Layer (SAL) is a hot, dry, and dust-laden feature that advects large concentrations of dust across the Atlantic annually to destination regions in the Americas and Caribbean. However, recent work has suggested the SAL may be a contributing factor to high-impact drought in the Caribbean basin. While the SAL's characteristic dust loadings have been the focus of much previous research, fewer efforts have holistically engaged the co-evolution of the dust plume, its associated convective environment, and resultant rainfall in Caribbean islands. This study employs a self-organizing map (SOM) classification to identify the common trans-Atlantic dust transport typologies …

Sacred Nutrition: Asserting Indigenous Sovereignty And Rights Of Women And Nature To Ensure The Right To Food In The United States, Mariana Chilton, Phd, Mph

University of Miami International and Comparative Law Review

This Paper is a provocation to move beyond a standard human rights and right to food framework to encourage scholars, activists, and political leaders to engage in full throttle societal transformation. Ending hunger in the United States demands nothing less. The modern human rights framework is enshrined in the modern nation-state system that is rooted in the transatlantic slave trade, colonization, and genocide.1 Three primary ways in which these roots took hold were through land theft, rape, and starvation. Hence, to assert that integrating the right to food and freedom from hunger into nation-state constitutions or into national plans to …

Life In A Fishbowl: Space And Environmental Enrichment Affect Behaviour Of Betta Splendens, Ronald G. Oldfield, Emily K. Murphy

Faculty Scholarship

The public has expressed growing concern for the well-being of fishes, including popular pet species such as the Siamese fighting fish (Betta splendens). In captivity, male Bettas behave aggressively, often causing injuries and death if housed together. As a result, they are typically isolated in small fishbowls, which has been widely criticised as cruel. To investigate the impact of keeping Bettas in these conditions, we recorded the behaviour of individual males in containers of different sizes that were either bare or enriched with gravel, large rocks, and live plants. When male Bettas were housed individually in small bowls (0.5 L) …

A New Species From Türkiye, Centaurea Turhanii (Cardueae, Asteraceae), Tuna Uysal, Meryem Bozkurt, Ergi̇n Hamzaoğlu

Turkish Journal of Botany

In this article, a new cornflower, Centaurea turhanii Uysal & Hamzaoğlu (Asteraceae) from Türkiye was described and reported. Morphological, karyological, and molecular analyses were used to reveal the taxonomic status of the new species with the species thought to be related to taxa. A modified determination key was submitted and its ecology and phenology were given.

Cover And Contents

Turkish Journal of Botany

No abstract provided.

A Comprehensive Study On The Molecular Characterization Of Tomato Spotted Wilt Orthotospovirus Isolates And Resistance Genes In Pepper And Tomato, Qurat Ul Ain Sajid, Emi̇nur Elçi̇

Turkish Journal of Botany

Tomato spotted wilt orthotospovirus (TSWV, Orthotospovirus tomatomaculae) resistance genes (Tsw, Sw5) have been identified in pepper and tomato plants. The development of resistant cultivars is one of the popular management strategies for overcoming viral infections. However, the breakdown of resistance genes has been documented from many places where resistant cultivars have been developed. This has mainly been due to the emergence of resistance-breaking (RB) lines because of the consecutive use of these cultivars. The development of these isolates may cause great losses in both tomato and pepper plants in Türkiye. To investigate the incidence of TSWV, 150 symptomatic samples were …

A Phylogenetic Analysis And Delimitation Of Turanecio (Asteraceae: Senecioneae), Meryem Bozkurt, Tuna Uysal, Ergi̇n Hamzaoğlu

Turkish Journal of Botany

Recently, Turanecio Hamzaoğlu was described as a new genus for the scientific world. Turanecio has been distributed as far as Asia, Iran, Caucasus, and Iraq. A phylogenetic analysis based on nrDNA and cpDNA gene regions was performed to determine the position of the genus within the subtribe Adenostylinae. Results from Bayesian and parsimony analyses of the nuclear and chloroplast DNA regions of the subtribe Senecioninae concordantly indicated that it is monophyletic and belongs to the Quadridentate group, with 4-lobed disc flowers. Nuclear DNA data revealed that some of the researched taxa should be transferred to Turanecio and some taxonomical classifications …

Classification Of Colorectal Cancer Using Resnet And Efficientnet Models, Abhishek Ranjan, Priyanshu Srivastva, B Prabadevi, R Sivakumar, Rahul Soangra, Shamala K. Subramaniam

Physical Therapy Faculty Articles and Research

Introduction:

Cancer is one of the most prevalent diseases from children to elderly adults. This will be deadly if not detected at an earlier stage of the cancerous cell formation, thereby increasing the mortality rate. One such cancer is colorectal cancer, caused due to abnormal growth in the rectum or colon. Early screening of colorectal cancer helps to identify these abnormal growth and can exterminate them before they turn into cancerous cells.

Aim:

Therefore, this study aims to develop a robust and efficient classification system for colorectal cancer through Convolutional Neural Networks (CNNs) on histological images.

Methods:

Despite challenges in …

Hidradenitis Suppurativa Disease Severity And Outcomes Among Black Patients From Low-Income Neighborhoods At A Tertiary Care Hospital: A Retrospective Review, Anna M. Catinis, Olivia A. Gioe, Caroline Savoie, Erika Rosen, Deborah Hilton

School of Medicine Faculty Publications

Hidradenitis suppurativa (HS) is a debilitating, inflammatory condition of apocrine sweat glands. Black patients are disproportionately affected, a finding largely attributed to lower socioeconomic status (SES) in the literature; yet, most HS studies include majority White cohorts. We present, to our knowledge, the first retrospective review of an entirely Black patient population living in low-income neighborhoods diagnosed with hidradenitis suppurativa (HS) to identify potentially modifiable factors related to disease severity and outcomes. We reviewed charts of Black patients with an encounter for HS from 2010-2020 in the New Orleans University Medical Center database. Hurley stage III (HSt III) disease was …

Genetic Variation In White Poplar (Populus Alba L.) Populations As Characterized By Ssr Markers, Burcu Uzan Eken, Emrah Kirdök, Ercan Veli̇oğlu, Yelda Özden Çi̇ftçi̇

Turkish Journal of Botany

The white poplar (Populus alba L.), which is tolerant to abiotic and biotic stresses, is a tree species that is resilient against changing climatic and environmental conditions, which makes it a suitable candidate for afforestation efforts. However, due to prolonged human intervention associated with the increasing population, the genetic resources of this species are at risk of loss. Additionally, while this species generally reproduces sexually, reproduction clonally via its root suckers has become widespread in some areas. Hence, the aim of this study was to investigate the genetic diversity of white poplar, which is increasingly experiencing genetic diversity loss. Herein, …

On The Border Of Extinction And Speciation, Polygala Seyfegoluensis (Polygalaceae), A New Species From Marshy Habitat, Central Türkiye: Under The Threat Of Climate Change, Water Retreat, And Subsequent Degradation, Ali̇ Aslan Dönmez, Zübeyde Uğurlu Aydin, İbrahi̇m Sirri Yüzbaşioğlu

Turkish Journal of Botany

Polygala seyfegoluensis Dönmez, Uğurlu & Yüzb. (Polygalaceae) is herein described and illustrated as a new species from Kırşehir Province around Seyfe Lake in Central Türkiye. This new species is similar to P. pruinosa and P. supina is distinctly characterized by its prostrate habit, nearly glabrous and smaller flower parts, and an unwinged capsule. A phylogenetic analysis was conducted to show the placement of the new species within selected Polygala taxa using the trnL-F and rbcL markers. Based on the field observation, an evolutionary scenario is proposed for the new species under the driving forces of climate change, the shrinking of …

The Respiratory Enzyme Complex Rnf Is Vital For Metabolic Adaptation And Virulence In Fusobacterium Nucleatum, Timmie A Britton, Chenggang Wu, Yi-Wei Chen, Dana Franklin, Yimin Chen, Martha I Camacho, Truc T Luong, Asis Das, Hung Ton-That

Faculty, Staff and Student Publications

The Gram-negative oral pathobiont Fusobacterium nucleatum can traverse to extra-oral sites such as placenta and colon, promoting adverse pregnancy outcomes and colorectal cancer, respectively. How this anaerobe sustains many metabolically changing environments enabling its virulence potential remains unclear. Informed by our genome-wide transposon mutagenesis, we report here that the highly conserved Rhodobacter nitrogen-fixation (Rnf) complex, encoded by the rnfCDGEAB gene cluster, is key to fusobacterial metabolic adaptation and virulence. Genetic disruption of the Rnf complex via non-polar, in-frame deletion of rnfC (ΔrnfC) abrogates polymicrobial interaction (or coaggregation) associated with adhesin RadD and biofilm formation. The defect in coaggregation …

Development And Validation Of A Nomogram For Predicting Pulmonary Infection In Patients Receiving Immunosuppressive Drugs, Chuxuan Luo, Yue Zhang, Jiajie Zhang, Chen Jin, Xiaolan Ye, Yan Ren, Huajuan Shen, Maosheng Chen, Yiwen Li, Qiang He, Guangbiao Xu, Lina Shao

Faculty, Staff and Student Publications

Objective: Pulmonary infection (PI), a severe complication of immunosuppressive therapy, affects patients' prognosis. As part of this study, we aimed to construct a pulmonary infection prediction (PIP) model and validate it in patients receiving immunosuppressive drugs (ISDs). Methods: Totally, 7,977 patients being treated with ISDs were randomised 7:3 to the developing (n = 5,583) versus validation datasets (n = 2,394). Our predictive nomogram was established using the least absolute shrinkage and selection operator (LASSO) and multivariate COX regression analyses. With the use of the concordance index (C-index) and calibration curve, the prediction performance of the final model was …

Expanded T Lymphocytes In The Cerebrospinal Fluid Of Multiple Sclerosis Patients Are Specific For Epstein-Barr-Virus-Infected B Cells, Assaf Gottlieb, H Phuong T Pham, Jerome G Saltarrelli, J William Lindsey

Faculty, Staff and Student Publications

Epstein-Barr virus (EBV) infection has long been associated with multiple sclerosis (MS), but the role of EBV in the pathogenesis of MS is not clear. Our hypothesis is that a major fraction of the expanded clones of T lymphocytes in the cerebrospinal fluid (CSF) are specific for autologous EBV-infected B cells. We obtained blood and CSF samples from eight relapsing-remitting patients in the process of diagnosis. We stimulated cells from the blood with autologous EBV-infected lymphoblastoid cell lines (LCL), EBV, varicella zoster virus, influenza, and candida and sorted the responding cells with flow cytometry after 6 d. We sequenced the …

In-Patient Evolution Of A High-Persister Escherichia Coli Strain With Reduced In Vivo Antibiotic Susceptibility, Joshua B Parsons, Ashelyn E Sidders, Amanda Z Velez, Blake M Hanson, Michelle Angeles-Solano, Felicia Ruffin, Sarah E Rowe, Cesar A Arias, Vance G Fowler, Joshua T Thaden, Brian P Conlon

Faculty, Staff and Student Publications

Gram-negative bacterial bloodstream infections (GNB-BSI) are common and frequently lethal. Despite appropriate antibiotic treatment, relapse of GNB-BSI with the same bacterial strain is common and associated with poor clinical outcomes and high healthcare costs. The role of persister cells, which are sub-populations of bacteria that survive for prolonged periods in the presence of bactericidal antibiotics, in relapse of GNB-BSI is unclear. Using a cohort of patients with relapsed GNB-BSI, we aimed to determine how the pathogen evolves within the patient between the initial and subsequent episodes of GNB-BSI and how these changes impact persistence. Using

Tomato Seedling Performance In Commercial Organic Growing Media, Elizabeth Maynard, Wenjing Guan, Petrus Langenhoven, Lori A. Hoagland

Department of Horticulture & Landscape Architecture Faculty Publications

Healthy transplants are critical to productivity in the field. For certified organic production in the United States, seedlings must be grown in media that meet the standards of the US Department of Agriculture’s National Organic Program. Many commercial organic media options are available, they vary substantially in composition, and it is unknown to what extent this influences seedling performance. This project compared tomato (Solanum lycopersicum L.) seedling emergence and growth in seven commercially available media for organic production and evaluated posttransplant performance. Tomato seedlings were grown in greenhouses at Wanatah, West Lafayette, and Vincennes, IN, USA. Chemical characteristics of …

Program Review Report 1-16-24, Angela Brock

Program Review Committee

No abstract provided.