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2024

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Recent Literature, Marine Ornithology Jan 2024

Recent Literature, Marine Ornithology

Marine Ornithology

No abstract provided.


Notes, Marine Ornithology Jan 2024

Notes, Marine Ornithology

Marine Ornithology

No abstract provided.


Crowned Cormorants On The Coast Of South West Africa/Namibia, P. D. Shaughnessy, G. L. Shaughnessy Jan 2024

Crowned Cormorants On The Coast Of South West Africa/Namibia, P. D. Shaughnessy, G. L. Shaughnessy

Marine Ornithology

No abstract provided.


Notes On Nonbreeding Seabirds At The Prince Edward Islands, A. J. Williams, A. E. Burger Jan 2024

Notes On Nonbreeding Seabirds At The Prince Edward Islands, A. J. Williams, A. E. Burger

Marine Ornithology

No abstract provided.


Diet Of Roseate Terns During The Breeding Season At St Croix Island, Algoa Bay, R. M. Randall, B. M. Randall Jan 2024

Diet Of Roseate Terns During The Breeding Season At St Croix Island, Algoa Bay, R. M. Randall, B. M. Randall

Marine Ornithology

No abstract provided.


The Potential Impact Of Ibuprofen On Level Of Il-6, Laith Ali Younus Jan 2024

The Potential Impact Of Ibuprofen On Level Of Il-6, Laith Ali Younus

Maaen Journal for Medical Sciences

Ibuprofen is a well-known Non-steroidal anti-inflammatory drugs (NSAID) that has historically been used for its analgesic, anti-inflammatory, and antipyretic effects. It is used as an over-the-counter pain reliever for conditions like headache, backache, muscle aches, toothaches, fever, and dysmenorrhea. It is used to treat chronic illnesses such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and others for an extended period of time. Due to its great efficacy compared to acetaminophen and relative safety compared to aspirin, it is also frequently used in juvenile patients to treat acute pain and fever by inhibiting prostaglandins, but they can also lower immunity by reducing …


The Forgotten Path Of Liberal Conservatism: What Yoram Hazony Ignores, Daniel J. Mahoney Jan 2024

The Forgotten Path Of Liberal Conservatism: What Yoram Hazony Ignores, Daniel J. Mahoney

The Journal of Contemporary Legal Issues

Today, in academic and intellectuals circles it is a besieged minority that affirms that the freest, most prosperous, most self-critical societies in the history of the world have been bequeathed a patrimony worth preserving. We have lost a meaningful and robust sense of what constitutes the West as the West (in fact, the term itself has no real resonance with the younger generations). The “Other” in faraway places, to use a fashionable abstraction, is beyond criticism since cultural and moral criticism are in those cases de rigueur; but the appropriate response to the faults of rule-of-law societies in the …


The Social Clerisy: Conservative Political Philosophy As A Philosophy Of Pluralism And The Social Group, Luke C. Sheahan Jan 2024

The Social Clerisy: Conservative Political Philosophy As A Philosophy Of Pluralism And The Social Group, Luke C. Sheahan

The Journal of Contemporary Legal Issues

Conservative political philosophers should be counted among, as Nisbet writes, “those thinkers who have resisted the appeal of the One, the unitary and monistic, and have found not merely reality but freedom and justice and equity to lie in plurality.” They should take as their starting point Nisbet’s tradition of the plural community. Given our place in history, following the increasing alienation and decline of social groups chronicled by Putnam and others, conservatives should feel free to pillage the ideas of pluralist thinkers outside the conservative tradition. Nisbet admits repeatedly throughout the decades of his long career that there seems …


The Student Movement Volume 108 Issue 12: Leaping Into The New Year!, Anneliese Tessalee, Savannah Tyler, Grace No, Aiko J. Ayala Rios, Madison Vath, Lexie Dunham, Daena Holbrook, Andrew Francis, Melissa Moore, Katie Davis, Nate Miller, Sumin Lee, Wambui Karanja, Alyssa Caruthers, Anna Rybachek, Chris Ngugi Jan 2024

The Student Movement Volume 108 Issue 12: Leaping Into The New Year!, Anneliese Tessalee, Savannah Tyler, Grace No, Aiko J. Ayala Rios, Madison Vath, Lexie Dunham, Daena Holbrook, Andrew Francis, Melissa Moore, Katie Davis, Nate Miller, Sumin Lee, Wambui Karanja, Alyssa Caruthers, Anna Rybachek, Chris Ngugi

The Student Movement v. 108 (2023-2024)

HUMANS

A Farewell and Goodbye From Your Graduates, Interviewed by Anneliese Tessalee

Making Peace with 2023, Interviewed by Savannah Tyler

Professor Jean Cadet and the NYC Marathon, Interviewed by Grace No

ARTS & ENTERTAINMENT

Upcoming events at HPAC, Aiko J. Ayala Rios

Music: The Forming of the Andrews University Symphony Orchestra, Madison Vath

The Media BREAKdown, Interviewed by Lexie Dunham

Christmas Traditions Across Andrews University, Daena Holbrook

NEWS

Michigan Football Ends Undefeated Season with NCAA Championship

Holiday Weekend Blast Brings Subzero Temperatures, Melissa Moore

Who is J.N. Andrews?, Andrew Francis

IDEAS

2024 the Plot, Katie Davis

Improving Andrews - Dorm …


Faculty Handbook Section Iii - College Of Liberal Arts Policies And Procedures - Updated 1/19/24, All Faculty Jan 2024

Faculty Handbook Section Iii - College Of Liberal Arts Policies And Procedures - Updated 1/19/24, All Faculty

Faculty Handbooks

No abstract provided.


Volume Cxliii, Number 10, January 19, 2024, Lawrence University Jan 2024

Volume Cxliii, Number 10, January 19, 2024, Lawrence University

The Lawrentian

No abstract provided.


Factors Associated With Hiv Testing Among Pregnant Women In Rwanda: A Nationwide Cross-Sectional Survey, Lilian Nuwabaine, Joseph Kawuki, Angella Namulema, John Baptist Asiimwe, Quraish Sserwanja, Ghislaine Gatasi, Elorm Donkor Jan 2024

Factors Associated With Hiv Testing Among Pregnant Women In Rwanda: A Nationwide Cross-Sectional Survey, Lilian Nuwabaine, Joseph Kawuki, Angella Namulema, John Baptist Asiimwe, Quraish Sserwanja, Ghislaine Gatasi, Elorm Donkor

School of Nursing & Midwifery, East Africa

Human immunodeficiency virus (HIV) testing during pregnancy is crucial for the prevention of mother-to-child transmission of HIV, through aiding prompt treatment, care, and support. However, few studies have explored HIV testing among pregnant women in Rwanda. This study, therefore, aimed to determine the prevalence and associated factors of HIV testing among pregnant women in Rwanda. We used secondary data from the 2020 Rwanda Demographic and Health Survey (RDHS), comprising 870 pregnant women. Multistage stratified sampling was used by the RDHS team to select participants. We conducted bivariable and multivariable logistic regression to explore factors associated with HIV testing using SPSS …


Synthesis And Biological Evaluation Of New Nicotinic Acid Derivatives As Potential Anti-Inflammatory Agents With Enhanced Gastric Safety Profile, Eman Ramadan, Zeinab Mahmoud, Nadia Khalil Jan 2024

Synthesis And Biological Evaluation Of New Nicotinic Acid Derivatives As Potential Anti-Inflammatory Agents With Enhanced Gastric Safety Profile, Eman Ramadan, Zeinab Mahmoud, Nadia Khalil

Pharmacy

Two innovative series derived from nicotinic acid scaffold were synthesized and evaluated for their anti-inflammatory activity. Ibuprofen, celecoxib and indomethacin were used as standard drugs. All the newly synthesized compounds were in vitro screened for their anti-inflammatory activity adopting 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide dye (MTT), as well as Griess assays. The results showed that all compounds exhibited significant anti-inflammatory activity without affecting the viability of the macrophages compared to ibuprofen. In addition, compounds 4d, 4f, 4g, 4h and 5b exhibited the most potent nitrite inhibition activity and consequently superior anti-inflammatory activity with MTT results ranging between values 86.109 ± 0.51 to 119.084 …


Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi Jan 2024

Implantation Of A Capsular Tension Ring During Cataract Surgery Attenuates Predicted Remodeling Of The Post-Surgical Lens Capsule Along The Visual Axis, Kurt A. Ameku, Caleb C. Berggren, Ryan M. Pedrigi

Department of Mechanical and Materials Engineering: Faculty Publications

Introduction: Cataract surgery permanently alters the mechanical environment of the lens capsule by placing a hole in the anterior portion and implanting an intraocular lens (IOL) that has a very different geometry from the native lens. We hypothesized that implant configuration and mechanical interactions with the post-surgical lens capsule play a key role in determining long-term fibrotic remodeling.

Methods: We developed the first finite element-growth and remodeling (FE-G&R) model of the post-surgical lens capsule to evaluate how implantation of an IOL with and without a capsular tension ring (CTR) impacted evolving lens capsule mechanics and associated fibrosis over …


January 19, 2024 Ereporter, University Of Alabama At Birmingham Jan 2024

January 19, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Roger Glass Center For The Arts Opens, University Of Dayton Jan 2024

Roger Glass Center For The Arts Opens, University Of Dayton

News Releases

Classes are underway at the Roger Glass Center for the Arts — where on any morning you might find a pre-law student learning stage makeup, a biology major hanging lights in the experimental theater, and a local artist preparing a new exhibit.


Synthesis And Characterization Of Bio Based Amphiphilic Molecules, Vandana Singh Jan 2024

Synthesis And Characterization Of Bio Based Amphiphilic Molecules, Vandana Singh

Theses and Dissertations

Among various molecular self-assemblies, low molecular weight gelators (LMWGs), that can form gels in organic solvents/water/oils, have gained much research attention due to their huge potential applications. Generally, gels are soft nanomaterials formed by the self-assembly of amphiphilic molecules into a three-dimensional fibrous network entrapping the solvent.

As these gels are formed by self-assembly via non-covalent interactions they are reversible and differ from macromolecular gels. To synthesize LMWGs, biomolecules such as fats, oils, fatty acids, lignocelluloses, sugars, amino acids, and peptides are commonly used as their inherent property favors self-assembly. In the current scenario, interest in synthesizing bio-based gelators has …


Is Hey Jude In The Right Key? Cognitive Components Of Absolute Pitch Memory, Stephen C. Van Hedger, Andrea Halpern, David J. Vollweiler, Evan E. Smith, Peter Q. Pfordresher Jan 2024

Is Hey Jude In The Right Key? Cognitive Components Of Absolute Pitch Memory, Stephen C. Van Hedger, Andrea Halpern, David J. Vollweiler, Evan E. Smith, Peter Q. Pfordresher

Faculty Journal Articles

Most individuals, regardless of formal musical training, have long-term absolute pitch memory (APM) for familiar musical recordings, though with varying levels of accuracy. The present study followed up on recent evidence suggesting an association between singing accuracy and APM (Halpern & Pfordresher, 2022, Attention, Perception, & Psychophysics, 84(1), 260–269), as well as tonal short-term memory (STM) and APM (Van Hedger et al., 2018, Quarterly Journal of Experimental Psychology, 71(4), 879–891). Participants from three research sites (n = 108) completed a battery of tasks including APM, tonal STM, singing accuracy, and self-reported auditory imagery. Both tonal STM and singing accuracy predicted …


Weakened Pelagic-Benthic Coupling On An Arctic Outflow Shelf (Northeast Greenland) Suggested By Benthic Ecosystem Changes, Yasemin V. Bodur, Paul E. Renaud, Lidia Lins, Luana Da Costa Monteiro, William G. Ambrose, Janine Felden, Thomas Krumpen, Frank Wenzhöfer, Maria Włodarska-Kowalczuk, Ulrike Braeckman Jan 2024

Weakened Pelagic-Benthic Coupling On An Arctic Outflow Shelf (Northeast Greenland) Suggested By Benthic Ecosystem Changes, Yasemin V. Bodur, Paul E. Renaud, Lidia Lins, Luana Da Costa Monteiro, William G. Ambrose, Janine Felden, Thomas Krumpen, Frank Wenzhöfer, Maria Włodarska-Kowalczuk, Ulrike Braeckman

Marine Science

Arctic marine ecosystems are becoming more boreal due to climate change. Predictions of ecosystem change focus mainly on Arctic inflow or interior shelves, with few comprehensive studies on Arctic outflow regions. During September–October 2017, soft-bottom communities were sampled and benthic ecosystem processes were quantified at 12 stations on the Northeast Greenland shelf (outflow shelf) and compared to the last regional ecosystem study, conducted in 1992 and 1993. The benthic habitat was characterized in terms of sediment granulometry, pigment concentrations, and porewater chemistry (dissolved inorganic carbon, nutrients). Total abundance and biomass of macrobenthos and meiobenthos, bacterial abundance, porewater dissolved inorganic carbon …


The Effects Of Police Officer Education And Academy Training Methods On Fair Decision Making, Benjamin Chapman Jan 2024

The Effects Of Police Officer Education And Academy Training Methods On Fair Decision Making, Benjamin Chapman

Research Papers

No abstract provided.


Ai-Enhanced Detection Of Clinically Relevant Structural And Functional Anomalies In Mri: Traversing The Landscape Of Conventional To Explainable Approaches, Pegah Khosravi, Saber Mohammadi, Fatemeh Zahiri, Masoud Khodarahmi, Javad Zahiri Jan 2024

Ai-Enhanced Detection Of Clinically Relevant Structural And Functional Anomalies In Mri: Traversing The Landscape Of Conventional To Explainable Approaches, Pegah Khosravi, Saber Mohammadi, Fatemeh Zahiri, Masoud Khodarahmi, Javad Zahiri

Publications and Research

Anomaly detection in medical imaging, particularly within the realm of magnetic resonance imaging (MRI), stands as a vital area of research with far-reaching implications across various medical fields. This review meticulously examines the integration of artificial intelligence (AI) in anomaly detection for MR images, spotlighting its transformative impact on medical diagnostics. We delve into the forefront of AI applications in MRI, exploring advanced machine learning (ML) and deep learning (DL) methodologies that are pivotal in enhancing the precision of diagnostic processes. The review provides a detailed analysis of preprocessing, feature extraction, classification, and segmentation techniques, alongside a comprehensive evaluation of …


Fibroblasts And Osteoblasts Behavior After Contact With Different Titanium Surfaces Used As Implant Abutment: An In Vitro Experimental Study, Jose Henrique Cavalcanti De Lima, Patricia Cristina Matos Robbs, Elena Mavropoulos Oliveira Tude, Piedad N. De Aza, Eleani Maria Da Costa, Antonio Scarano, Juan Carlos Prados-Frutos, Gustavo Fernandes, Sergio Alexandre Gehrke Jan 2024

Fibroblasts And Osteoblasts Behavior After Contact With Different Titanium Surfaces Used As Implant Abutment: An In Vitro Experimental Study, Jose Henrique Cavalcanti De Lima, Patricia Cristina Matos Robbs, Elena Mavropoulos Oliveira Tude, Piedad N. De Aza, Eleani Maria Da Costa, Antonio Scarano, Juan Carlos Prados-Frutos, Gustavo Fernandes, Sergio Alexandre Gehrke

MOSDOH Faculty Publications

Background: The goal of this in vitro study was to compare three different surfaces: two types of implant surfaces commercially available ([a] smooth/machined and [b] acid-treated surface) versus (c) anodized surface. Discs were manufactured with commercially pure titanium (CP) grade IV, which were subsequently analyzed by scanning microscopy and fibroblastic and osteoblastic cell cultures. Methods: Ninety-nine discs (5 × 2 mm) were manufactured in titanium grade IV and received different surface treatments: (i) Mach group: machined; (ii) AA group: double acid etch; and (iii) AN group: anodizing treatment. Three discs from each group were analyzed by Scanning Electron Microscopy (SEM) …


Augusta: From Rna-Seq To Gene Regulatory Networks And Boolean Models, Jana Musilova, Zdenek Vafek, Bhanwar Lal Puniya, Ralf Zimmer, Tomáš Helikar, Karel Sedlar Jan 2024

Augusta: From Rna-Seq To Gene Regulatory Networks And Boolean Models, Jana Musilova, Zdenek Vafek, Bhanwar Lal Puniya, Ralf Zimmer, Tomáš Helikar, Karel Sedlar

Department of Biochemistry: Faculty Publications

Computational models of gene regulations help to understand regulatory mechanisms and are extensively used in a wide range of areas, e.g., biotechnology or medicine, with significant benefits. Unfortunately, there are only a few computational gene regulatory models of whole genomes allowing static and dynamic analysis due to the lack of sophisticated tools for their reconstruction. Here, we describe Augusta, an open-source Python package for Gene Regulatory Network (GRN) and Boolean Network (BN) inference from the high-throughput gene expression data. Augusta can reconstruct genome-wide models suitable for static and dynamic analyses. Augusta uses a unique approach where the first estimation of …


Is Unplanned Excision Of Soft Tissue Sarcomas Associated With Worse Oncological Outcomes?-A Systematic Review And Meta-Analysis, Juan Pretell Jan 2024

Is Unplanned Excision Of Soft Tissue Sarcomas Associated With Worse Oncological Outcomes?-A Systematic Review And Meta-Analysis, Juan Pretell

All Publications

Background: Soft tissue sarcomas are a group of rare neoplasms which can be mistaken for benign masses and be excised in a non-oncologic fashion (unplanned excision). Whether unplanned excision (UE) is associated with worse outcomes is highly debated due to conflicting evidence.

Methods: We performed a systematic review and meta-analysis following PRISMA guidelines. Main outcomes analyzed were five-year overall survival (OS), five-year local recurrence-free survival (LRFS), amputation rate and plastic reconstruction surgery rate. Risk ratios were used to compare outcomes between patients treated with planned and unplanned excision.

Results: We included 16,946 patients with STS, 6017 (35.5%) with UE. UE …


Comprehensive Workflow And Its Validation For Simulating Diffuse Speckle Statistics For Optical Blood Flow Measurements, Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen-Hao P Lin, Nishighanda Patil, Sumana Chetia, Jason W Trobaugh, Joseph P Culver, Turgut Durduran Jan 2024

Comprehensive Workflow And Its Validation For Simulating Diffuse Speckle Statistics For Optical Blood Flow Measurements, Lisa Kobayashi Frisk, Manish Verma, Faruk Bešlija, Chen-Hao P Lin, Nishighanda Patil, Sumana Chetia, Jason W Trobaugh, Joseph P Culver, Turgut Durduran

2020-Current year OA Pubs

Diffuse optical methods including speckle contrast optical spectroscopy and tomography (SCOS and SCOT), use speckle contrast (


Exploring The Role Of Information And Communication Technologies In Allergic Rhinitis In Specialist Centers: Patient Perspectives On Usefulness, Value, And Impact On Healthcare, Ivan Cherrez-Ojeda, Jean Bousquet, Zouina Sarfraz, Azza Sarfraz, Monica Rodriguez Gonzales, Anna Bedbrook, Nelson Rosario, Benjamin Zepeda-Ortega, Guillermo Guidos, Ulbio Alcivar Molina Jan 2024

Exploring The Role Of Information And Communication Technologies In Allergic Rhinitis In Specialist Centers: Patient Perspectives On Usefulness, Value, And Impact On Healthcare, Ivan Cherrez-Ojeda, Jean Bousquet, Zouina Sarfraz, Azza Sarfraz, Monica Rodriguez Gonzales, Anna Bedbrook, Nelson Rosario, Benjamin Zepeda-Ortega, Guillermo Guidos, Ulbio Alcivar Molina

Department of Paediatrics and Child Health

Introduction: Information and communication technologies (ICTs) improve patient-centered care and are routinely used in Allergic Rhinitis (AR), but patients' preferences and attitudes are unexplored. This study examines AR-related information preferences and ICT use by AR patients.
Methods: A survey-based cross-sectional study was carried out in Ecuador from July to September 2019 in seven centers of reference for allergic disease. Participants were 18 years or older, diagnosed with AR and had access to ICT and the Internet. Descriptive and binomial logistic regressions were performed. A value of less than 0.05 was considered statistically significant.
Results: 217 patients were included. 47% (n …


Hyperstructures In Chemical Hyperstructures Of Redox Reactions With Three And Four Oxidation States, Fakhry Asad Agusfrianto, Sonea Andromeda, Mariam Hariri Jan 2024

Hyperstructures In Chemical Hyperstructures Of Redox Reactions With Three And Four Oxidation States, Fakhry Asad Agusfrianto, Sonea Andromeda, Mariam Hariri

All Works

Hyperstructures find numerous applications across various disciplines. One notable application is in chemistry, particularly in the context of chemical reactions. In 2014, Davvaz introduced the concept of bi-hyperstructures, but their application specifically in chemical reactions, has yet to be thoroughly explored in previous studies. Thus, the primary aim of this paper is to examine and analyze the different types of bi-hyperstructures present within chemical hyperstructures. The scope of this study focuses on two types of chemical hyperstructures: redox reactions and reactions in electrochemical cells. Within these chemical hyperstructures, we investigate the possibility of bi-hyperstructures among bi-semihypergroups, bi-hypergroups, bi-H_v-semigroups, and bi-H_v-groups. …


Deepvelo: Deep Learning Extends Rna Velocity To Multi-Lineage Systems With Cell-Specific Kinetics, Haotian Cui, Hassaan Maan, Maria C Vladoiu, Jiao Zhang, Michael D Taylor, Bo Wang Jan 2024

Deepvelo: Deep Learning Extends Rna Velocity To Multi-Lineage Systems With Cell-Specific Kinetics, Haotian Cui, Hassaan Maan, Maria C Vladoiu, Jiao Zhang, Michael D Taylor, Bo Wang

Faculty, Staff and Students Publications

Existing RNA velocity estimation methods strongly rely on predefined dynamics and cell-agnostic constant transcriptional kinetic rates, assumptions often violated in complex and heterogeneous single-cell RNA sequencing (scRNA-seq) data. Using a graph convolution network, DeepVelo overcomes these limitations by generalizing RNA velocity to cell populations containing time-dependent kinetics and multiple lineages. DeepVelo infers time-varying cellular rates of transcription, splicing, and degradation, recovers each cell's stage in the differentiation process, and detects functionally relevant driver genes regulating these processes. Application to various developmental and pathogenic processes demonstrates DeepVelo's capacity to study complex differentiation and lineage decision events in heterogeneous scRNA-seq data.


Epstein-Barr Virus-Based Prognostic Model In Nodular Sclerosis Classic Hodgkin Lymphoma, Chen Jiang, Li-Yun Huang, Ji-Hao Zhou, Zhi-Ming Li, Yu Wang, Shuo Li, Jian-Chang Fu, Qi-Tao Huang, Qin Yan, Yu-Yuan Huang, Min Zuo, Shimin Hu, Robert Peter Gale, Yang Liang, Jing-Ping Yun, Yu-Hua Huang Jan 2024

Epstein-Barr Virus-Based Prognostic Model In Nodular Sclerosis Classic Hodgkin Lymphoma, Chen Jiang, Li-Yun Huang, Ji-Hao Zhou, Zhi-Ming Li, Yu Wang, Shuo Li, Jian-Chang Fu, Qi-Tao Huang, Qin Yan, Yu-Yuan Huang, Min Zuo, Shimin Hu, Robert Peter Gale, Yang Liang, Jing-Ping Yun, Yu-Hua Huang

Faculty, Staff and Student Publications

The role of Epstein-Barr virus (EBV) in lymphoma cells of nodular sclerosis classic Hodgkin lymphoma (NScHL) is controversial. Our aim was to explore this and establish a clinically feasible model for risk stratification. We interrogated data from 542 consecutive subjects with NScHL receiving ABVD therapy and demonstrated EBV-infection in their lymphoma cells with EBV-encoded small RNAs (EBERs) in situ hybridization. Subjects were divided into training and validation datasets. As data from the training dataset suggested EBERs-positivity was the only independent prognostic factor for both progression-free survival (PFS) and overall survival (OS), we developed corresponding prognostic models based on it. Our …


Induced Degradation Of Lineage-Specific Oncoproteins Drives The Therapeutic Vulnerability Of Small Cell Lung Cancer To Parp Inhibitors, Chiho Kim, Xu-Dong Wang, Zhengshuai Liu, Jianwei Hao, Shuai Wang, Peng Li, Zhenzhen Zi, Qing Ding, Seoyeon Jang, Jiwoong Kim, Yikai Luo, Kenneth E Huffman, Shreoshi Pal Choudhuri, Sofia Del Rio, Ling Cai, Han Liang, Benjamin J Drapkin, John D Minna, Yonghao Yu Jan 2024

Induced Degradation Of Lineage-Specific Oncoproteins Drives The Therapeutic Vulnerability Of Small Cell Lung Cancer To Parp Inhibitors, Chiho Kim, Xu-Dong Wang, Zhengshuai Liu, Jianwei Hao, Shuai Wang, Peng Li, Zhenzhen Zi, Qing Ding, Seoyeon Jang, Jiwoong Kim, Yikai Luo, Kenneth E Huffman, Shreoshi Pal Choudhuri, Sofia Del Rio, Ling Cai, Han Liang, Benjamin J Drapkin, John D Minna, Yonghao Yu

Faculty, Staff and Student Publications

Although BRCA1/2 mutations are not commonly found in small cell lung cancer (SCLC), a substantial fraction of SCLC shows clinically relevant response to PARP inhibitors (PARPis). However, the underlying mechanism(s) of PARPi sensitivity in SCLC is poorly understood. We performed quantitative proteomic analyses and identified proteomic changes that signify PARPi responses in SCLC cells. We found that the vulnerability of SCLC to PARPi could be explained by the degradation of lineage-specific oncoproteins (e.g., ASCL1). PARPi-induced activation of the E3 ligase HUWE1 mediated the ubiquitin-proteasome system (UPS)-dependent ASCL1 degradation. Although PARPi induced a general DNA damage response in SCLC cells, this …