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Molecular Mechanisms In Pathophysiology Of Mucopolysaccharidosis And Prospects For Innovative Therapy, Yasuhiko Ago, Estera Rintz, Krishna Sai Musini, Zhengyu Ma, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidoses (MPSs) are a group of inborn errors of the metabolism caused by a deficiency in the lysosomal enzymes required to break down molecules called glycosaminoglycans (GAGs). These GAGs accumulate over time in various tissues and disrupt multiple biological systems, including catabolism of other substances, autophagy, and mitochondrial function. These pathological changes ultimately increase oxidative stress and activate innate immunity and inflammation. We have described the pathophysiology of MPS and activated inflammation in this paper, starting with accumulating the primary storage materials, GAGs. At the initial stage of GAG accumulation, affected tissues/cells are reversibly affected but progress irreversibly to: (1) …

Comparison Of Three Rapid Diagnostic Tests For Bloodstream Infections Using Benefit-Risk Evaluation Framework (Bed-Frame), Richard D Smith, Min Zhan, Shanshan Zhang, Surbhi Leekha, Anthony Harris, Yohei Doi, Scott Evans, J Kristie Johnson, Robert K Ernst

Faculty, Staff and Student Publications

Rapid diagnostic tests (RDTs) for bloodstream infections have the potential to reduce time to appropriate antimicrobial therapy and improve patient outcomes. Previously, an in-house, lipid-based, matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) method, Fast Lipid Analysis Technique (FLAT MS), has shown promise as a rapid pathogen identification method. In this study, FLAT MS for direct from blood culture identification was evaluated and compared to FDA-cleared identification methods using the Benefit-risk Evaluation Framework (BED-FRAME) analysis. FLAT MS was evaluated and compared to Bruker Sepsityper and bioMérieux BioFire FilmArray BCID2 using results from a previous study. For this study, 301 …

Draft Genomes Of 12 Bifidobacterium Isolates From Human Ibd Fecal Samples, Cole E Souza, Nicole E Jacobson, Michelle A An, Lindsay Droit, Alejandro A Vega, Mariel Rosales, Kathie A Mihindukulasuriya, Karina Pastrana, Scott A Handley, Miles Parkes, Joanna Rimmer, David Wang, Elizabeth A Dinsdale, Robert A Edwards, Anca M Segall

2020-Current year OA Pubs

Twelve

Pressing Need Of Precision Care In Her2-Positive Colorectal Cancer: The Elephant In The Room, Kanwal P S Raghav, Jonathan M Loree, Scott Kopetz

Faculty, Staff and Student Publications

Although dual HER2 inhibition has shown promising clinical activity in patients with RAS wild-type HER2-positive metastatic colorectal cancer, predictive biomarkers of response/resistance are less well characterized. Activating HER2/RTK/MAPK genomic alterations appears to blunt the clinical benefit of dual anti-HER2 therapy and may hold a potential albeit partial role in patient selection. See related article by Randon et al., p. 436.

Cdk4/6 Inhibition Sensitizes Intracranial Tumors To Pd-1 Blockade In Preclinical Models Of Brain Metastasis, Naema Nayyar, Magali A De Sauvage, Jane Chuprin, Emily M Sullivan, Mohini Singh, Consuelo Torrini, Britney S Zhang, Sushobhana Bandyopadhyay, Keith A Daniels, Christopher Alvarez-Breckenridge, Ashish Dahal, Michael A Brehm, Priscilla K Brastianos

Faculty, Staff and Student Publications

PURPOSE: Brain metastases are associated with high morbidity and are often resistant to immune checkpoint inhibitors. We evaluated whether CDK4/6 inhibitor (CDKi) abemaciclib can sensitize intracranial tumors to programmed cell death protein 1 (PD-1) inhibition in mouse models of melanoma and breast cancer brain metastasis.

EXPERIMENTAL DESIGN: Treatment response was evaluated in vivo using immunocompetent mouse models of brain metastasis bearing concurrent intracranial and extracranial tumors. Treatment effect on intracranial and extracranial tumor-immune microenvironments (TIME) was evaluated using immunofluorescence, multiplex immunoassays, high-parameter flow cytometry, and T-cell receptor profiling. Mice with humanized immune systems were evaluated using flow cytometry to study …

2024-01-17 Redhawks Soar Abroad, Bridget Lawrence

The Spectator Online

No abstract provided.

Prevalence Of Entamoeba Histolytica Among Patients Attending Al-Zubair General Hospital In Basra Province /Iraq, Sarah Naser

Al-Ameed Journal for Medical Research and Health Sciences

Background: Besides malaria and schistosomiasis, Entamoeba histolytica the most important sources of illness and death in humans worldwide. The prevalence of E. histolytica in Basra province has received little research and it is critical in Basra city to identify and manage the risk factors connected to the parasite.

Aims: The objective of this research is to provide insight into the prevalence of amoebiasis among patients who attended Al-Zubair General Hospital during period 2020, 2021 and 2022.

Procedure: For the purpose of to detect and diagnose E. histolytica infection, (2,145) stool samples from patients attending Al-Zubair General Hospital in Basra province/ …

Study A Relationship Between Age, Body Mass Index, And Sperm Parameters With Sperm Dna Fragmentation Levels In Iraqi Infertile Patients, Talal Z. Al-Darawsha, Nurten Dayioglu, Bushra R. Al-Azzawi, Tulay Irez

Al-Ameed Journal for Medical Research and Health Sciences

Background: Male infertility is complex and accounts for approximately 50% of couples facing conception challenges. Factors such as body mass index, age, and sperm parameters play significant roles. Recognizing their impact is vital for diagnosis and treatment. Aim of the study: The study aimed to evaluate DNA integrity in individuals with unexplained infertility and assess its correlation with age, body mass index, and semen parameters. Materials and Methods: In this study, 111 males who met the inclusion criteria were recruited for our study. Selected participants were grouped according to their age, body mass index, and semen parameters, including (sperm count, …

Genetically Caused Oral Disorders: Pathogenesis And Treatment: A Review, Ali Alsuraifi, Abdullah Ayad, Yousif Husam, Noor Alhuda R. Mohammed, Fatimah H. Mahdi, Jassem Mohammed, Zainab M. Sulaiman, Sarah Kareem

Al-Ameed Journal for Medical Research and Health Sciences

The mouth is a unique and intricate structure composed of various anatomical components that work together effectively to perform various functions. The oral cavity can be affected by various disorders, such as genetic diseases, infections, and metabolic disorders. A wide range of genetic disorders can affect the skeletal system, including craniofacial structures and teeth. These disorders exhibit a significant variety in terms of their causes when they show up, and how severe they are. Genetics is a significant risk factor in the development of oral diseases. It affects the pattern of inheritance, which can be dominant, recessive, or both. The …

Testosterone Hormone ; Clinical Indications, Dysregulation And Therapeutic Methods, Talal Z. Al-Darawsha

Al-Ameed Journal for Medical Research and Health Sciences

Testosterone is a hormone primarily produced by the testicles in adult men and it is the basic male sex hormone and an anabolic steroid. Androgen is important for survival. It is influences a man's appearance and sexual development, stimulating sperm production and regulating sex drive. This hormone is a key growth factor in prostate gland. Prostatic cells stop thriving when testosterone levels fall and Prostate cancer cells shrink both benign and malignant. Testosterone deficiency is a clinical and biochemical syndrome that is linked to ageing and is characterized by typical symptoms and a testosterone deficiency in the blood. The number …

Clinical Management Of Larsen Syndrome In Inpatient Rehabilitation: A Case Report, Philippe J. Dentino

Research Symposium

Background: Larsen Syndrome is a rare osteochondrodysplasic disorder associated with Filamin 1 (FLN) gene mutations and clinically presents with frequent large joint dislocations, osseous disturbances, and craniofacial abnormalities. To date, no studies have assessed the medical and rehabilitative management of an individual living with Larsen Syndrome in an inpatient rehabilitation care setting.

Case Presentation: A 30 year-old biological female presented to the emergency department after developing worsening right-sided low back pain while bending forward. The patient’s past medical and surgical history was significant for Larsen Syndrome complicated by chronic hip, knee, and back pain, Celiac disease, major depressive disorder, post-traumatic …

What Is Task-Oriented Training? A Scoping Review, Erin Halford, Samantha Jakubiszak, Kassidy Krug, Amanda Umphress

Student Journal of Occupational Therapy

Task-Oriented Training (TOT) is an proven stroke rehabilitation intervention with significant evidence-based research that supports its effectiveness. The absence of a clear definition has led to variability in research reporting and subsequent confusion with practical implementation. A consistent definition seeks to remedy this ambiguity to facilitate knowledge translation. The objective of this study was to determine a comprehensive definition of TOT that encapsulates previous definitions and descriptions in the literature. In order to derive this definition, a two stage scoping review process was conducted across four databases searching for articles on the use of TOT in adult stroke rehabilitation therapy. …

Cloran Hodges Stewart

African American Funeral Programs

No abstract provided.

Cas Connections- 2024 Spring Term - January, Dean's Office College Of Arts And Science

CAS Connections

No abstract provided.

Winona State University Academics Blog: 2011-2024, Winona State University

Winona State University Blogs

The Winona State University (WSU) Academic Blog inlcudes articles and entries from May 2011- January 2024. Note: there may be format coding in the document.

Biographical Memoirs: Napoleon A. Chagnon, Raymond B. Hames

Department of Anthropology: Faculty Publications

Napoleon A. Chagnon (August 27, 1938–September 21, 2019), elected to the National Academy of Science in 2012. A Biographical Memoir by Raymond B. Hames, University of Nebraska-Lincoln.

Chagnon was a Renaissance anthropologist who made numerous fundamental contributions to anthropology. His films and ethnography have been viewed by millions around the world. He combined a humanistic eye in research with an unwavering scientific approach to human culture and behavior. He set multiple standards for long-term field research in terms of methodological rigor and refinement. He made some of the first tests of inclusive fitness theory in human behavior. And he was …

Electron Effective Mass In Gan Revisited: New Insights From Terahertz And Mid-Infrared Optical Hall Effect, Nerijus Armakavicius, Sean Knight, Philipp Kühne, Vallery Stanishev, Dat Q. Tran, Steffen Richter, Alexis Papamichail, Megan Stokey, Preston Sorensen, Ufuk Kilic, Mathias Schubert, Plamen P. Paskov, Vanya Darakchieva

Department of Electrical and Computer Engineering: Faculty Publications

Electron effective mass is a fundamental material parameter defining the free charge carrier transport properties, but it is very challenging to be experimentally determined at high temperatures relevant to device operation. In this work, we obtain the electron effective mass parameters in a Si-doped GaN bulk substrate and epitaxial layers from terahertz (THz) and mid-infrared (MIR) optical Hall effect (OHE) measurements in the temperature range of 38–340 K. The OHE data are analyzed using the well-accepted Drude model to account for the free charge carrier contributions. A strong temperature dependence of the electron effective mass parameter in both bulk and …

Broadscale Coral Disease Interventions Elicit Efficiencies In Endemic Disease Response, Kathryn A. Toth, Samantha F. Buckley, Hunter Noren, Karen L. Neely, Brian K. Walker

Marine & Environmental Sciences Faculty Articles

The presence and abundance of reef-building corals are crucial to the long-term existence of Caribbean coral reef ecosystems, providing both direct and indirect, local and global, ecological, economic, and social benefits. In 2014, stony coral tissue loss disease (SCTLD) was first identified in southeast Florida and remains endemic to the region, while continuing to spread throughout the Caribbean. Effective in situ intervention treatments using antibiotic paste can halt lesion progression on Montastraea cavernosa up to 90% of the time. This study investigated intervention activities over a three-year period to identify efficiencies in disease response. Since May 2019, 1,037 corals, >85% …

The Relationship Between The Saharan Air Layer, Convective Environmental Conditions, And Precipitation In Puerto Rico, P. W. Miller, C. Ramseyer

Faculty Publications

The Saharan Air Layer (SAL) is a hot, dry, and dust-laden feature that advects large concentrations of dust across the Atlantic annually to destination regions in the Americas and Caribbean. However, recent work has suggested the SAL may be a contributing factor to high-impact drought in the Caribbean basin. While the SAL's characteristic dust loadings have been the focus of much previous research, fewer efforts have holistically engaged the co-evolution of the dust plume, its associated convective environment, and resultant rainfall in Caribbean islands. This study employs a self-organizing map (SOM) classification to identify the common trans-Atlantic dust transport typologies …

Sacred Nutrition: Asserting Indigenous Sovereignty And Rights Of Women And Nature To Ensure The Right To Food In The United States, Mariana Chilton, Phd, Mph

University of Miami International and Comparative Law Review

This Paper is a provocation to move beyond a standard human rights and right to food framework to encourage scholars, activists, and political leaders to engage in full throttle societal transformation. Ending hunger in the United States demands nothing less. The modern human rights framework is enshrined in the modern nation-state system that is rooted in the transatlantic slave trade, colonization, and genocide.1 Three primary ways in which these roots took hold were through land theft, rape, and starvation. Hence, to assert that integrating the right to food and freedom from hunger into nation-state constitutions or into national plans to …

Life In A Fishbowl: Space And Environmental Enrichment Affect Behaviour Of Betta Splendens, Ronald G. Oldfield, Emily K. Murphy

Faculty Scholarship

The public has expressed growing concern for the well-being of fishes, including popular pet species such as the Siamese fighting fish (Betta splendens). In captivity, male Bettas behave aggressively, often causing injuries and death if housed together. As a result, they are typically isolated in small fishbowls, which has been widely criticised as cruel. To investigate the impact of keeping Bettas in these conditions, we recorded the behaviour of individual males in containers of different sizes that were either bare or enriched with gravel, large rocks, and live plants. When male Bettas were housed individually in small bowls (0.5 L) …

Development And Validation Of A Nomogram For Predicting Pulmonary Infection In Patients Receiving Immunosuppressive Drugs, Chuxuan Luo, Yue Zhang, Jiajie Zhang, Chen Jin, Xiaolan Ye, Yan Ren, Huajuan Shen, Maosheng Chen, Yiwen Li, Qiang He, Guangbiao Xu, Lina Shao

Faculty, Staff and Student Publications

Objective: Pulmonary infection (PI), a severe complication of immunosuppressive therapy, affects patients' prognosis. As part of this study, we aimed to construct a pulmonary infection prediction (PIP) model and validate it in patients receiving immunosuppressive drugs (ISDs). Methods: Totally, 7,977 patients being treated with ISDs were randomised 7:3 to the developing (n = 5,583) versus validation datasets (n = 2,394). Our predictive nomogram was established using the least absolute shrinkage and selection operator (LASSO) and multivariate COX regression analyses. With the use of the concordance index (C-index) and calibration curve, the prediction performance of the final model was …

Microbiome Preterm Birth Dream Challenge: Crowdsourcing Machine Learning Approaches To Advance Preterm Birth Research, Jonathan L. Golob, Tomiko T. Oskotsky, Alice S. Tang, Alennie Roldan, Verena Chung, Connie W. Ha, Abigail Kuntzleman, Isaac Bigcraft, Et Al.

Michigan Tech Publications

Every year, 11% of infants are born preterm with significant health consequences, with the vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) preterm birth (PTB < 37 weeks) or (2) early preterm birth (ePTB < 32 weeks) from 9 vaginal microbiome studies representing 3,578 samples from 1,268 pregnant individuals, aggregated from public raw data via phylogenetic harmonization. The predictive models are validated on two independent unpublished datasets representing 331 samples from 148 pregnant individuals. The top-performing models (among 148 and 121 submissions from 318 teams) achieve area under the receiver operator characteristic (AUROC) curve scores of 0.69 and 0.87 predicting PTB and ePTB, respectively. Alpha diversity, VALENCIA community state types, and composition are important features in the top-performing models, most of which are tree-based methods. This work is a model for translation of microbiome data into clinically relevant predictive models and to better understand preterm birth.

Expanded T Lymphocytes In The Cerebrospinal Fluid Of Multiple Sclerosis Patients Are Specific For Epstein-Barr-Virus-Infected B Cells, Assaf Gottlieb, H Phuong T Pham, Jerome G Saltarrelli, J William Lindsey

Faculty, Staff and Student Publications

Epstein-Barr virus (EBV) infection has long been associated with multiple sclerosis (MS), but the role of EBV in the pathogenesis of MS is not clear. Our hypothesis is that a major fraction of the expanded clones of T lymphocytes in the cerebrospinal fluid (CSF) are specific for autologous EBV-infected B cells. We obtained blood and CSF samples from eight relapsing-remitting patients in the process of diagnosis. We stimulated cells from the blood with autologous EBV-infected lymphoblastoid cell lines (LCL), EBV, varicella zoster virus, influenza, and candida and sorted the responding cells with flow cytometry after 6 d. We sequenced the …

Microbiome Preterm Birth Dream Challenge: Crowdsourcing Machine Learning Approaches To Advance Preterm Birth Research, Jonathan L. Golob, Tomiko T. Oskotsky, Alice S. Tang, Alennie Roldan, Verena Chung, Connie W.Y. Ha, Abigail Kuntzleman, Isaac Bigcraft, Stephen Techtmann, Et Al.

Michigan Tech Publications

Every year, 11% of infants are born preterm with significant health consequences, with the vaginal microbiome a risk factor for preterm birth. We crowdsource models to predict (1) preterm birth (PTB; <37 >weeks) or (2) early preterm birth (ePTB; <32 >weeks) from 9 vaginal microbiome studies representing 3,578 samples from 1,268 pregnant individuals, aggregated from public raw data via phylogenetic harmonization. The predictive models are validated on two independent unpublished datasets representing 331 samples from 148 pregnant individuals. The top-performing models (among 148 and 121 submissions from 318 teams) achieve area under the receiver operator characteristic (AUROC) curve scores of 0.69 and …

Novel Pan-Err Agonists Ameliorate Heart Failure Through Enhancing Cardiac Fatty Acid Metabolism And Mitochondrial Function, Weiyi Xu, Cyrielle Billon, Hui Li, Andrea Wilderman, Lei Qi, Andrea Graves, Jernie Rae Dela Cruz Rideb, Yuanbiao Zhao, Matthew Hayes, Keyang Yu, Mckenna Losby, Carissa S Hampton, Christiana M Adeyemi, Seok Jae Hong, Eleni Nasiotis, Chen Fu, Tae Gyu Oh, Weiwei Fan, Michael Downes, Ryan D Welch, Ronald M Evans, Aleksandar Milosavljevic, John K Walker, Brian C Jensen, Liming Pei, Thomas Burris, Lilei Zhang

Faculty, Staff and Students Publications

BACKGROUND: Cardiac metabolic dysfunction is a hallmark of heart failure (HF). Estrogen-related receptors ERRα and ERRγ are essential regulators of cardiac metabolism. Therefore, activation of ERR could be a potential therapeutic intervention for HF. However, in vivo studies demonstrating the potential usefulness of ERR agonist for HF treatment are lacking, because compounds with pharmacokinetics appropriate for in vivo use have not been available.

METHODS: Using a structure-based design approach, we designed and synthesized 2 structurally distinct pan-ERR agonists, SLU-PP-332 and SLU-PP-915. We investigated the effect of ERR agonist on cardiac function in a pressure overload-induced HF model in vivo. We …

A New Species From Türkiye, Centaurea Turhanii (Cardueae, Asteraceae), Tuna Uysal, Meryem Bozkurt, Ergi̇n Hamzaoğlu

Turkish Journal of Botany

In this article, a new cornflower, Centaurea turhanii Uysal & Hamzaoğlu (Asteraceae) from Türkiye was described and reported. Morphological, karyological, and molecular analyses were used to reveal the taxonomic status of the new species with the species thought to be related to taxa. A modified determination key was submitted and its ecology and phenology were given.

Cover And Contents

Turkish Journal of Botany

No abstract provided.

A Comprehensive Study On The Molecular Characterization Of Tomato Spotted Wilt Orthotospovirus Isolates And Resistance Genes In Pepper And Tomato, Qurat Ul Ain Sajid, Emi̇nur Elçi̇

Turkish Journal of Botany

Tomato spotted wilt orthotospovirus (TSWV, Orthotospovirus tomatomaculae) resistance genes (Tsw, Sw5) have been identified in pepper and tomato plants. The development of resistant cultivars is one of the popular management strategies for overcoming viral infections. However, the breakdown of resistance genes has been documented from many places where resistant cultivars have been developed. This has mainly been due to the emergence of resistance-breaking (RB) lines because of the consecutive use of these cultivars. The development of these isolates may cause great losses in both tomato and pepper plants in Türkiye. To investigate the incidence of TSWV, 150 symptomatic samples were …

A Phylogenetic Analysis And Delimitation Of Turanecio (Asteraceae: Senecioneae), Meryem Bozkurt, Tuna Uysal, Ergi̇n Hamzaoğlu

Turkish Journal of Botany

Recently, Turanecio Hamzaoğlu was described as a new genus for the scientific world. Turanecio has been distributed as far as Asia, Iran, Caucasus, and Iraq. A phylogenetic analysis based on nrDNA and cpDNA gene regions was performed to determine the position of the genus within the subtribe Adenostylinae. Results from Bayesian and parsimony analyses of the nuclear and chloroplast DNA regions of the subtribe Senecioninae concordantly indicated that it is monophyletic and belongs to the Quadridentate group, with 4-lobed disc flowers. Nuclear DNA data revealed that some of the researched taxa should be transferred to Turanecio and some taxonomical classifications …