Digital Commons Network^™

Museum Preparedness In The Digital Age, Mary Jatkowski

School of Information Sciences Student Scholarship

In 2001, Neil Beagrie coined the term, “digital curation” at the Digital Preservation Coalition sponsored conference in London. This new term launched a field of study which has since beenadopted by various disciplines within the sciences and humanities. Cultural heritage organizations like libraries and archives adapted the new field, by refining and formalizing standards and practices of digital curation to cater to their diverse cultural and historical collections. LIS graduate programs have embraced the field of study with rigorous curricula like DigCCurr which trains students in the various aspects of curation and preservation, from metadata standards to selection and …

The Minutes Of The Marshall University Graduate Council Meeting, January 26, 2024, Marshall University Graduate Council

Graduate Council Minutes

No abstract provided.

Association Of Genetic Variation In Col11a1 With Adolescent Idiopathic Scoliosis, Hao Yu, Lilian Antunes, Christina A Gurnett, Et Al.

2020-Current year OA Pubs

Adolescent idiopathic scoliosis (AIS) is a common and progressive spinal deformity in children that exhibits striking sexual dimorphism, with girls at more than fivefold greater risk of severe disease compared to boys. Despite its medical impact, the molecular mechanisms that drive AIS are largely unknown. We previously defined a female-specific AIS genetic risk locus in an enhancer near the

Tempo And Mode Of Gene Expression Evolution In The Brain Across Primates, Katherine Rickelton, Trisha M Zintel, Jason Pizzollo, Emily Miller, John J Ely, Mary Ann Raghanti, William D Hopkins, Patrick R Hof, Chet C Sherwood, Amy L Bauernfeind, Courtney C Babbitt

2020-Current year OA Pubs

Primate evolution has led to a remarkable diversity of behavioral specializations and pronounced brain size variation among species (Barton, 2012; DeCasien and Higham, 2019; Powell et al., 2017). Gene expression provides a promising opportunity for studying the molecular basis of brain evolution, but it has been explored in very few primate species to date (e.g. Khaitovich et al., 2005; Khrameeva et al., 2020; Ma et al., 2022; Somel et al., 2009). To understand the landscape of gene expression evolution across the primate lineage, we generated and analyzed RNA-seq data from four brain regions in an unprecedented eighteen species. Here, we …

Panther - April 2015 - Vol. Xcv, Issue 6, Prairie View A&M University

PV Panther Newspapers 2015

No abstract provided.

Pathogenicity Prediction Of Gabaa Receptor Missense Variants, Ya-Juan Wang, Giang H. Vu, Ting-Wei Mu

Faculty Scholarship

Variants in the genes encoding gamma-aminobutyric acid type A (GABAA) receptor subunits are associated with epilepsy. To date, over 1000 clinical variants have been identified in these genes. However, the majority of these variants lack functional studies and their clinical significance is uncertain although accumulating evidence indicates that proteostasis deficiency is the major disease-causing mechanism. Here, we apply two state-of-the-art modeling tools, namely AlphaMissense and Rhapsody to predict the pathogenicity of saturating missense variants in genes that encode the major subunits of GABAA receptors in the central nervous system, including GABRA1, GABRB2, GABRB3, and GABRG2. We demonstrate that the predicted …

Cd133-Dependent Activation Of Phosphoinositide 3-Kinase /Akt/Mammalian Target Of Rapamycin Signaling In Melanoma Progression And Drug Resistance, Naji Kharouf, Thomas W. Flanagan, Abdulhadi A. Alamodi, Youssef Al Hmada, Sofie Yasmin Hassan, Hosam Shalaby, Simeon Santourlidis, Sarah Lilly Hassan, Youssef Haikel, Mossad Megahed, Robert T. Brodell, Mohamed Hassan

School of Medicine Faculty Publications

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in melanoma progression and drug resistance is well documented, targeting the PI3K/AKT/mTOR pathway showed less efficiency in clinical trials than might have been expected, since the suppression of the PI3K/mTOR signaling pathway-induced feedback loops is mostly associated with the activation of compensatory pathways such as MAPK/MEK/ERK. Consequently, the development of intrinsic and acquired resistance can occur. As a solid tumor, melanoma is notorious for its heterogeneity. This can be expressed in the form of genetically divergent …

Unveiling The Unique Ras Isoform And Domain Specific Regulation Of Braf Kinase, Tarah Trebino

Theses and Dissertations

BRAF kinase is a key member of the MAPK pathway, important for cell growth and division. Upstream signals promote BRAF activation by interaction with the membrane bound GTPase, RAS, which leads to relief of autoinhibition and dimerization. The N-terminal regulatory domains of BRAF, including the BRAF specific region (BSR), the RAS binding domain (RBD), and the cysteine rich domain (CRD), govern the conformational state of the cytosolic, autoinhibited monomer and drive the RAS-RAF interaction. Active BRAF phosphorylates and activates its substrate MEK, which in turn phosphorylates and activates ERK. Mutations in RAS and BRAF are the cause of many cancers …

Bacterial Contamination Of Platelet Products, Michael R Jacobs, Bowen Zhou, Aditi Tayal, Robert W Maitta

Faculty, Staff and Student Publications

Transfusion of bacterially contaminated platelets, although rare, is still a major cause of mortality and morbidity despite the introduction of many methods to limit this over the past 20 years. The methods used include improved donor skin disinfection, diversion of the first part of donations, use of apheresis platelet units rather than whole-blood derived pools, primary and secondary testing by culture or rapid test, and use of pathogen reduction. Primary culture has been in use the US since 2004, using culture 24 h after collection of volumes of 4-8 mL from apheresis collections and whole-blood derived pools inoculated into aerobic …

The Diamond, January 26, 2024, Dordt University

Dordt Diamond

• Front Page: Planting for the Future Campaign Raises over $100 Million; Diving Headfirst: Dordt Adds Swim Team; Izzy the Studious Corgi Goes to College
• News: Trump Campaigns in Sioux Center; Entrepreneurship Program Continues to Grow; Caucusing in the Cold; Student Government Creates New Position
• Feature:AMOR Students Travel to Tanzania and Liberia; Kwik Trip Comes to Sioux Center; When in Rome; Little but Fierce: Dordt Stands out at Theatre Festival Snowpocalypse at Dordt
• Opinion: One Bottle is Enough; Get in Loser, We're Watching Mean Girls; Wonka Embraces the Over-the-Top
• Arts & Entertainment: Dordt Orchestra Tours over …

Yoga’S Journey From East To West: A Tale Of Adaptation, Wellness, And Healing The Balancing Act, Christine D. Walck

Publications

Prepare for a unique journey through the world of yoga with an opinionated, funny twist. Join a devout Catholic, a PhD-toting engineering professor, and an extreme athlete as they navigate the intriguing yet mysterious realm of yoga. Their initial skepticism, rooted in Eastern philosophy, quickly dissolves as yoga seamlessly melds with their Catholic faith, offering a universal path to physical and mental well-being. Buckle up for a humorous takedown of common misconceptions about yoga’s compatibility with Western religious beliefs. It’s all about respecting the body, which conveniently aligns with their active (with a dash of clumsy adventures thrown in). Yoga …

Personalized Trial Ethics And Institutional Review Board Submissions, Joyce P Samuel, Susan H Wootton

Faculty, Staff and Student Publications

The ethical and regulatory oversight of any clinical activity related to human subjects is commonly determined based on its categorization as either clinical practice or research. Prominent bioethicists have criticized the traditional distinctions used to delineate these categories, calling them counterproductive and outmoded, and arguing that learning and clinical practice should be deliberately and appropriately integrated. Personalized trials represent a clinical activity with characteristics that overlap both categories, making ethical and regulatory oversight requirements less straightforward. When the primary intent of the personalized trial is to assist in the conduct of individualized patient care with an emphasis on protecting the …

Identification Of Differentially Recognized T Cell Epitopes In The Spectrum Of Tuberculosis Infection, Sudhasini Panda, Jeffrey Morgan, Catherine Cheng, Mayuko Saito, Robert H. Gilman, Nelly Ciobanu, Valeriu Crudu, Donald G. Cantazaro, Antonino Cantazaro, Timothy Rodwell, Judy S.B. Perera, Teshan Chathuranga, Bandu Gunasena, Aruna D. Desilva, Bjoern Peters, Alessandro Sette, Cecilia S. Linderstam Arlehamn

Biological Sciences Faculty Publications and Presentations

There is still incomplete knowledge of which Mycobacterium tuberculosis (Mtb) antigens can trigger distinct T cell responses at different stages of infection. Here, a proteome-wide screen of 20,610 Mtb-derived peptides in 21 patients mid-treatment for active tuberculosis (ATB) reveals IFNγ-specific T cell responses against 137 unique epitopes. Of these, 16% are recognized by two or more participants and predominantly derived from cell wall and cell processes antigens. There is differential recognition of antigens, including TB vaccine candidate antigens, between ATB participants and interferon-gamma release assay (IGRA + /−) individuals. We developed an ATB-specific peptide pool (ATB116) consisting of epitopes exclusively …

Ubr5 Promotes Antiviral Immunity By Disengaging The Transcriptional Brake On Rig-I Like Receptors, Duomeng Yang, Tingting Geng, Andrew G Harrison, Jason G Cahoon, Jian Xing, Baihai Jiao, Mark Wang, Chao Cheng, Robert E Hill, Huadong Wang, Anthony T Vella, Gong Cheng, Yanlin Wang, Penghua Wang

Faculty, Staff and Students Publications

The Retinoic acid-Inducible Gene I (RIG-I) like receptors (RLRs) are the major viral RNA sensors essential for the initiation of antiviral immune responses. RLRs are subjected to stringent transcriptional and posttranslational regulations, of which ubiquitination is one of the most important. However, the role of ubiquitination in RLR transcription is unknown. Here, we screen 375 definite ubiquitin ligase knockout cell lines and identify Ubiquitin Protein Ligase E3 Component N-Recognin 5 (UBR5) as a positive regulator of RLR transcription. UBR5 deficiency reduces antiviral immune responses to RNA viruses, while increases viral replication in primary cells and mice. Ubr5 knockout mice are …

Perspectives Of The Blue Economy Development In The Russian Sector Of The Black Sea, Evgeniia Kostianaia, Andrey Kostianoy

Journal of Ocean and Coastal Economics

The paper discusses the current state and perspectives for the development of various sectors of the Blue Economy in the Russian sector of the Black Sea. This analysis is based on the research done in the framework of the EU DOORS (Developing Optimal and Open Research Support for the Black Sea) research project (2021-2024), reports by the World Bank and the European Commission, as well as scientific literature of the Russian and international researchers. The main Blue Economy sectors in the Russian sector of the Black Sea basin are maritime transport, port activities, and coastal tourism. The authors also provide …

Medical School Watercooler Newsletter - January 25, 2024, Lindsey Lyle

Watercooler Newsletter

This is the January 25, 2024 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Whiddon COM alumna returns to USA Health as hospitalist
• Meet a Med Student: Ryan McIlwain
• OB/GYN Student Interest Group hosts period product drive through Feb. 9
• Grelet presents research at mitochondria conference in Berlin

January 2024 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Episode 8: The End Of The Beginning, Sara Gras

Season 01

This final episode closes with some final thoughts from most of my guests about where this issue currently stands, where it could be headed, and what we should be doing with our concerns in the meantime.

Look for more episodes of Hearsay from the Sidelines coming later in 2024!

Dara Purvis (Faculty Profile)
Associate Dean for Research and Partnerships & Professor of Law, Penn State Law
Works referenced:

• Dara E. Purvis, Transgender Children, Teaching Early Acceptance, and the Heckler’s Veto, 72 Stud. L. Pol. Soc’y 219 (2017).
• Dara E. Purvis, Transgender Students and the First Amendment (Forthcoming), …

Behavioral Effects Of Novel Treatments For Pain Using Different Pathways, Danya M I Aldaghma

Theses and Dissertations

Pain is defined as an unpleasant sensation that is mostly caused by a stimulus from our surroundings. This sensation has the potential to become a significant concern, disrupting daily activities, and diminishing overall quality of life. However, it could also hold significant importance as it serves as a protective mechanism. Pain acts as an alarm system for the human body, alerting it to potentially harmful situations where tissues may be at risk of damage1. Despite the considerable advancements in pain treatment and the extensive knowledge scientists possess regarding the pathophysiology and pathways of pain, numerous medications aimed at alleviating pain …

Insights On The Future Of Digital Health: An Analysis Of Twitter Posts Of Imia Fellows, David T Marc, Karima Lalani, Susan H Fenton, Kerryn Butler-Henderson

Faculty, Staff and Student Publications

The COVID-19 pandemic has reshaped technology-enhanced services in health and care organizations globally. As the world pivots towards a post-COVID-19 environment, it is essential to examine emerging trends amongst thought leaders in the health information technology sector. This study queried Twitter feeds of IMIA Fellows from 2013 through 2022, utilizing combinations of sentiment analysis, latent dirichlet allocation, and document analysis methods. The results provided a glimpse of positive sentiment year upon year, with the most negative sentiment prevalent in 2020, due to the onset of the pandemic. The findings from this study can be strategically used to analyze emerging trends …

Pluralism, Political Creeds, And Competing Ontologies: Faith Leaders As A Resource For Navigating Polarization, Bruce J. Clemenger

Consensus

No abstract provided.

A House Divided: The Structure Of Political Polarization Analyzed, Jeffrey Dudiak

Consensus

No abstract provided.

Investigation Of Machine Learning Driven Adaptive Control Strategy For Heat Exchanger Under Varying Fouling Conditions, Reshma Madhu Pk

Theses and Dissertations

Fouling is an undesirable and inevitable phenomenon that affects Heat Exchanger (HE) dynamics, increases maintenance cost (>50%), and loss of production. Conventional fouling prediction and control techniques demand an in-depth understanding of the HE-specific fouling dynamics. Hence, machine learning emerges as an ideal tool for learning the fouling process from the available measurement dataset.

The proposed work aims to design a machine learning-driven adaptive control technique for an industrial HE, subjected to varying fouling conditions. Naphtha cooler, an industrial HE utilized in petroleum refineries, employs cooling water to lower Naphtha temperature, but the high impurities in the recycled cooling …

Dietary And Therapeutic Benefits Of Edible Insects: A Global Perspective, Chrysantus Mbi Tanga, Sunday Ekesi

All Peer-Reviewed Publications

Edible insects are gaining traction worldwide for research and development. This review synthesizes a large and well-established body of research literature on the high nutritional value and variety of pharmacological properties of edible insects. Positive benefits of insect-derived products include immune enhancement; gastrointestinal protection; antitumor, antioxidant, and anti-inflammatory capacities; antibacterial activities; blood lipid and glucose regulation; lowering of blood pressure; and decreased risk of cardiovascular diseases. However, the pharmacological mechanisms of these active components of edible insects in humans have received limited research attention. In addition, we discuss health risks (safety); application prospects; regulations and policies governing their production and …

Leverage Of Salvadora Persica And Pulicaria Undulata Extracts In Escherichia Coli-Challenged Broiler Chickens, Mohamed A. Lebda, Ahd. A. Mansour, Esraa M. Elieba, Shahira A. Hassoubah, Fatemah Almalki, Mohamed Abu El-Magd, Sara I. Othman, Ahmed M. Allam, Guillermo Tellez-Isaias, Ayman E. Taha

Poultry Science Faculty Publications and Presentations

Escherichia coli (E. coli) is a significant challenge in the poultry industry due to their related use of antimicrobial compounds and the drastic losses in production and livability. This study investigated the preventive impacts of dietary supplementation of Salvadora persica (SP) and/or Pulicaria undulata (PU) extracts on growth traits, biochemical and immune parameters, and related gene expression of E. coli-infected broilers. A total of 120 one-day-old Cobb broilers were used. The chicks were allocated into eight equal groups (3 replicates/ group; 5 chicks per each replicate) as follows: G1; control negative, G2; SP-treated, G3; …

Habitat Characterization Of American Badgers (Taxidea Taxus) Of Northern California, Mitchell Victoria

Master's Theses

American badgers (Taxidea taxus) are a semi fossorial mammal that lives in grassland and open prairie ecosystems as well as coastal prairies, agricultural fields, deserts, and deforested habitats. Many researchers have published work on badgers, but we still require more information on their ecology. The American badger is a semi fossorial, solitary, predatory mammal of grassland ecosystems. They are classified as mesopredators when compared to larger apex predators such as brown bears, wolves, and pumas. However, when larger carnivores are absent, Badgers become apex predators of their ecosystems. Los Vaqueros Watershed in Brentwood, California, was my study site because badgers …

Circulating Metabolic Profile In Idiopathic Pulmonary Fibrosis: Data From The Ipf-Pro Registry, Ross Summer, Jamie Todd, Megan Neely, L. Jason Lobo, Andrew Namen, L. Kristin Newby, Shirin Shafazand, Sally Suliman, Christian Hesslinger, Sascha Keller, Thomas Leonard, Scott M Palmer, Olga Ilkayeva, Michael Muehlbauer, Christopher Newgard, Jesse Roman

Division of Pulmonary, Allergy, and Critical Care Medicine Faculty Papers

BACKGROUND: The circulating metabolome, reflecting underlying cellular processes and disease biology, has not been fully characterized in patients with idiopathic pulmonary fibrosis (IPF). We evaluated whether circulating levels of metabolites correlate with the presence of IPF, with the severity of IPF, or with the risk of clinically relevant outcomes among patients with IPF.

METHODS: We analyzed enrollment plasma samples from 300 patients with IPF in the IPF-PRO Registry and 100 individuals without known lung disease using a set of targeted metabolomics and clinical analyte modules. Linear regression was used to compare metabolite and clinical analyte levels between patients with IPF …

The Current - Volume 34 Issue 7, Nova Southeastern University

Student Newspapers

No abstract provided.

How Do Women Feel Cold Water Swimming Affects Their Menstrual And Perimenopausal Symptoms?, Megan Pound, Heather Massey, Sasha Roseneil, Ruth Williamson, C. Mark Harper, Mike Tipton, Jill Shawe, Malika Felton, Joyce C. Harper

School of Nursing and Midwifery

Objective: This study aimed to determine how women felt cold water swimming affected their menstrual and perimenopausal symptoms. Study design: An online survey that asked women who regularly swim in cold water about their experiences. The survey was advertised for 2 months on social media. Questions related to cold water swimming habits and menstrual and perimenopausal symptoms were analysed. Main outcome measures: Quantitative and qualitative data including; frequency of menstrual and menopause symptoms, the effect of cold water swimming on these symptoms. Results: 1114 women completed the survey. Women reported that cold water swimming reduced their menstrual symptoms, notably psychological …

Interplay Between Atrx And Idh1 Mutations Governs Innate Immune Responses In Diffuse Gliomas, Seethalakshmi Hariharan, Benjamin T Whitfield, Christopher J Pirozzi, Matthew S Waitkus, Michael C Brown, Michelle L Bowie, David M Irvin, Kristen Roso, Rebecca Fuller, Janell Hostettler, Sharvari Dharmaiah, Emiley A Gibson, Aaron Briley, Avani Mangoli, Casey Fraley, Mariah Shobande, Kevin Stevenson, Gao Zhang, Prit Benny Malgulwar, Hannah Roberts, Martin Roskoski, Ivan Spasojevic, Stephen T Keir, Yiping He, Maria G Castro, Jason T Huse, David M Ashley

Faculty, Staff and Student Publications

Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been implicated in dysfunctional immune signaling. However, little is known about the interplay between ATRX loss and IDH mutation on innate immunity. To explore this, we generated ATRX-deficient glioma models in the presence and absence of the IDH1R132H mutation. ATRX-deficient glioma cells are sensitive to dsRNA-based innate immune agonism and exhibit impaired lethality and increased T-cell infiltration in vivo. However, the presence of IDH1R132H dampens baseline expression of key innate immune genes …