Digital Commons Network^™

Reaction Hijacking Inhibition Of Plasmodium Falciparum Asparagine Trna Synthetase, Stanley C Xie, Eva S Istvan, Daniel E Goldberg, Et Al.

2020-Current year OA Pubs

Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold. We show that the exemplar, OSM-S-106, has potent activity against parasite cultures, low mammalian cell toxicity and low propensity for resistance development. In vitro evolution of resistance using a slow ramp-up approach pointed to the Plasmodium falciparum cytoplasmic asparaginyl-tRNA synthetase (PfAsnRS) as the target, consistent with our finding that OSM-S-106 inhibits protein …

Links Between The Three-Dimensional Movements Of Whale Sharks (Rhincodon Typus) And The Bio-Physical Environment Off A Coral Reef, Ben D'Antonio, Luciana Ferreira, Mark Meekan, Paul Thompson, Lilian Lieber, Patti Virtue, Chloe Power, Charitha Pattiaratchi, Andrew Brierley, Ana Sequeira, Michele Thums

School of Biological and Marine Sciences

BackgroundMeasuring coastal-pelagic prey fields at scales relevant to the movements of marine predators is challenging due to the dynamic and ephemeral nature of these environments. Whale sharks (Rhincodon typus) are thought to aggregate in nearshore tropical waters due to seasonally enhanced foraging opportunities. This implies that the three-dimensional movements of these animals may be associated with bio-physical properties that enhance prey availability. To date, few studies have tested this hypothesis.MethodsHere, we conducted ship-based acoustic surveys, net tows and water column profiling (salinity, temperature, chlorophyll fluorescence) to determine the volumetric density, distribution and community composition of mesozooplankton (predominantly euphausiids and copepods) …

Ogilvie's Syndrome: Acute Colonic Pseudoobstruction. A Review For Residents., Tyler Bayliss, Caleb Clark, Errington C. Thompson

Marshall Journal of Medicine

Ogilvie's syndrome (acute colonic pseudoobstruction) was first described in 1948. Acute colonic pseudoobstruction can occur in a variety of clinical settings, including postsurgical, obstetrics, pelvic surgery, critical care and sepsis. Clinicians need to recognize the syndrome early. Colonic distention without evidence of obstruction can be seen on plain films of the abdomen or CT scan. Successful therapies, including bowel rest, neostigmine and colonoscopic decompression, have been used. Avoiding respiratory compromise from abdominal distention and colonic perforation of the primary goals of treatment. Surgical intervention should be reserved for patients who are refractory to medical treatment or develops signs and symptoms …

More Physicians Alone Won’T Solve Rural America’S Health Care Problems, Atul Grover

Marshall Journal of Medicine

Policymakers have voiced their hope that locating family doctors and other primary care physicians within rural communities would, by itself, improve the health status of rural residents. However, access does not necessarily translate to better health. Rural populations face disproportionately worse health outcomes and inequities compared to urban populations. To improve the health care of rural America, it is critical to define—and periodically reassess—the problem and identify varying targeted policies.

Book Review: Surgery And Salvation: The Roots Of Reproductive Injustice In Mexico, 1770-1940, Madhavi Venkatesan

Journal of International Women's Studies

No abstract provided.

Book Review: The Gender Order Of Neoliberalism, Jamin A. Hübner

Journal of International Women's Studies

No abstract provided.

Jordanian Women In Academia: Barriers And Motivators In Scientific Research And Promotion, Abeer Al Bawab, Rana Dajani, Lubna Akroush, Rania Ahmad Jaber, Abeer Bashier Dababneh, Muna Yacoub Hindiyeh, Fairouz M. Aldhmour, Sabha Alkam, Zaina Muqbel, Yazan A. Al-Ajlouni

Journal of International Women's Studies

The purpose of this study is to evaluate the research output and status of women academics in science fields in Jordan. The rationale is to identify trends as well as challenges to advise policy makers and university administrators on how to promote more involvement of women academics within the university. A survey of two sections was developed. The first section included 36 items that measure demographics and challenges in academic, research, administrative, and family contexts. The second section included questions regarding motivators and barriers to academic research. Participants were prompted to respond per the Likert’s Scale, where the responses were …

Transformed Feminist Spaces And Identity Construction: Women Pandwani Performers In Indian Folk Theater, Shalini Attri

Journal of International Women's Studies

Theater proposes an alternative reality and different possible identities offering a framework of how representation works in performances, and it further provides an understanding of the transformative potential of enactment. The attempt to retrieve and re-write women’s histories through performances develops a culture of reconstructive capacities that resists absorption into the dominant culture. In theater, women have asserted their own vision and exercised their own viewpoints, expanding feminist space and communicating with spectators by employing publicly encoded signs. The folk theater of India, in particular, provides a public space to the (silenced) subaltern to assert agency and question the modalities …

Inactive Women As A Result Of The Gender-Based Division Of Labor: The Virtualcall Project As A Possible Solution, Ebru Işık

Journal of International Women's Studies

Today, many women are excluded from the labor market despite having a good education. Perhaps the most obvious reason for this situation is the gender-based division of labor. Because of this division of labor, women are mostly considered to be responsible for domestic work and care work and it becomes difficult for them to go out of the house. Such women are not able to participate in the labor market due to their domestic responsibilities and are currently considered inactive. Economic inactivity, a huge problem for many European countries including Turkey, excludes a great potential human resource that will be …

Women’S Empowerment And The Honey Production Projects In The Protected Areas Of Usumacinta Canyon, Mexico, Paola Selene Vera-Martínez, Erika Guadalupe Ceballos-Falcón

Journal of International Women's Studies

Beekeeping is an activity with positive effects for biodiversity and food security; furthermore, it is compatible with the conservation objectives of protected areas. Likewise, previous studies show that the participation of women in beekeeping projects gives them access to paid work and triggers the possibility of their empowerment. The aim of the article is to explore the process of women’s empowerment as one of the social results that derives from the meliponic farmers and beekeepers’ projects implemented in the protected area of the Usumacinta Canyon, Mexico. For this research project, visits were made to the places of honey production in …

Work-Family Conflict And Stress: A Triangulated Analysis Of The Plight Of Working Mothers In Nigerian Universities, Ngozi Christiana Nwadike, John T. Okpa, Nnana Okoi Ofem, Godfrey Ekene Odinka, Frank Mbeh Attah, Pius Otu Abang, Antigha Umo Bassey

Journal of International Women's Studies

This study investigated the plight of working mothers of children under the age of 18 at the University of Nigeria within the context of work-family conflict, using data from a cross-sectional sample of 485 academic and non-academic staff selected through a multi-staged sampling technique. Data were obtained using questionnaires and seven IDI (in-depth interview) respondents. Data were analyzed using descriptive statistics such as percentages and frequency tables, while the Chi-square was used to examine the study variables. The results indicated that there is a statistically significant relationship between couples living together and the stress experience of working mothers with under-age …

Bioethics Of Human Cloning: Are We Playing God?, Caleb Smith, Mary Katherine Flage

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

Caring, 1979, V3 N2, Summer, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has an article with advice on how to navigate medical care as well as news about staffing, publications, events, and other updates.

There is a 10-year follow up to the "Tranquility Ball" and fundraising event with Buzz Aldrin in 1969. For more information on this event, see this issue of Around & About Illinois Masonic Medical Center.

Caring, 1980 V4 N3, Fall/Winter, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Medical Center, Chicago, IL: Issue of "Caring", a quarterly patient education publication. This issue has a history of the nursing school at IMMC on its 60th anniversary, as well as news about staffing, publications, events, and other updates.

This is the last issue the library has in this format. The title continues in a new format here: Caring, 1987 Winter

Infusing Quantitative Reasoning Skills Into A Differential Equation Class In An Urban Public Community College, Tanvir Prince

Numeracy

This research centers on implementing Quantitative Reasoning (QR) within a differential equations course at an urban public community college. As a participant in the Numeracy Infusion for College Educators (NICE) faculty development program, I sought to integrate QR skills into my curriculum. Students in the course were introduced to QR goals using real-world data sets, particularly those related to population growth, which aim to enhance their understanding, sharpen their problem-solving abilities, and cultivate a positive perspective on the real-world relevance of mathematics. Preliminary findings indicate varied levels of QR skill development among students. These results underscore the potential benefits of …

Sr 23-24-21 Apc, Marshall University Faculty Senate

Recommendations

No abstract provided.

Parallels Of Quantum Superposition In Ecological Models: From Counterintuitive Patterns To Eco-Evolutionary Interpretations Of Cryptic Species, David G. Angeler, Hannah B. Fried-Petersen

School of Natural Resources: Faculty Publications

Background Superposition, i.e. the ability of a particle (electron, photon) to occur in different states or positions simultaneously, is a hallmark in the subatomic world of quantum mechanics. Although counterintuitive at first sight, the quantum world has potential to inform macro-systems of people and nature. Using time series and spatial analysis of bird, phytoplankton and benthic invertebrate communities, this paper shows that superposition can occur analogously in redundancy analysis (RDA) frequently used by ecologists.

Results We show that within individual ecosystems single species can be associated simultaneously with different orthogonal axes in RDA models, which suggests that they operate in …

U.S. Food & Drug Administration V. Alliance For Hippocratic Medicine: Brief For Food And Drug Law Scholars And Professors As Amici Curiae Supporting Petitioners And Reversal, Rebecca S. Eisenberg

Appellate Briefs

Amici curiae are U.S. food and drug law scholars and professors from academic institutions across the United States. A full list of amici is included as an Appendix to this brief. Amici have expertise in food and drug law, including the drug approval process and regulation of pharmaceuticals under the Federal Food, Drug, and Cosmetic Act (FDCA), 21 U.S.C. § 301 et seq. Amici submit this brief to address important issues raised by this case concerning the authority of the U.S. Food & Drug Administration (FDA or the Agency) to regulate prescription drugs.

The Federal Food, Drug, and Cosmetic Act …

The Phenomenology Of Abstract Awe: A Qualitative Study Of Lived Experiences In Psychedelic Virtual Reality, Jacob Spinks

Psychology ETDs

This thesis investigates individuals' experiences with SoundSelf, a virtual reality (VR) program inspired by psychedelic experience, focusing on its capacity to evoke awe and other self-transcendent experiences. Conducted with fifteen participants, the study involved a single VR session followed by in-depth phenomenological interviews. Through a thematic analysis, three primary themes were constructed: (a) emotions and feelings, the good and the bad; (b) non-reflective engagements, directly living experience; and (c) reflective engagements, exploring curiosity and wonder. The findings indicate that while SoundSelf can elicit a wide array of emotions and self-transcendent experiences, it does not consistently induce awe. This research contributes …

Effects Of Sodium Hypochlorite On The Physicochemical Characteristics Of Arrowhead Starch, Xi Wanting, Liu Guiru, Li Meng, Ji Derong, Duan Lili

Food and Machinery

Objective: The effect of sodium hypochlorite on the physicochemical properties and digestive characteristics of arrowhead starch was studied. Methods: In a weakly alkaline environment, sodium hypochlorite was used as an oxidant, and the added amounts were 0%, 1%, 3%, 5%, 7%, and 9% (based on the mass fraction of available chlorine in dry basis arrowhead starch). Following a 4-hour oxidation reaction with arrowhead starch, the modified starch's amylose content, swelling power, solubility, coagulation stability, color difference, light transmittance, scanning electron microscopy, X-ray diffraction, and other physical and chemical properties were measured, along with its digestibility. Results: The amylose concentration, solubility …

Effects Of Two-Step Heating Process On Hydrophobicity And Barrier Properties Of Protein-Based Composites, Wang Zi, Lei Qiao, Zhang Wenhui

Food and Machinery

Objective: To improve the film heating process. Methods: In this experiment, edible protein-polysaccharide films were prepared by using the method of chain dissociation at 35, 40, 45, 50, 55 ℃ at one stage and denaturing and heating whey protein isolation at 85 ℃ at the second stage. The structure, hydrophobicity, barrier properties and mechanical properties of the films were compared, and the optimum film forming process conditions were determined. Results: The oxygen resistance, tensile strength （TS） and elongation at break （EAB） of the film increased by 25.0%~58.7%, 54.8%~89.9% and 40.2%~59.2%, respectively, when the film was heated at 25 ℃ and …

Research On Internal Temperature Temporal And Spatial Distribution Of Citrus Peel In Heat Treatment Process, Zhao Yao, He Zhaoying, Jiang Yuhong, Cai Xiangyu, Li Shiquan

Food and Machinery

Objective: This study aimed to obtain the temperature distribution law of different points in citrus fruit over time during heat treatment. Methods: The temperature change of citrus peel during heat treatment was studied from the perspective of heat transfer. A new method was applied to calculate the temperature transfer rule in citrus peel, and a new mathematical model was established to simulate the temperature distribution of citrus peel during heat treatment. The spatial and temporal distribution of the internal temperature field of three kinds of citrus (Fengjie Navel orange, longevity blood orange and Ziyang Tangerine) was studied. Results: The study …

Effects Of Matcha On Lipid Oxidation During Storage Of Coix Seed, Chen Chan, Huang Jing

Food and Machinery

Objective: This study aimed to study the effect of matcha on lipid oxidation during the storage of coix seed. Methods: The fresh coix seeds were used as raw material and treated with matcha tea powder in different doses. The changes in water content, fatty acid value, peroxidation value, malondialdehyde content, total number of colonies and key enzyme of lipid oxidation were determined during the storage of coix seeds. Results: The treatment with different doses of matcha powder could inhibit the increase of fatty acid value, peroxide value, malondialdehyde content, lipase, and lipoxygenase activities, and reduce water consumption and microbial growth …

Application Of Surface-Enhanced Raman Spectroscopy In Food Safety Detection, Wang Liuliu, Sun Fangtao

Food and Machinery

Based on Raman scattering phenomenon, surface-enhanced Raman spectroscopy （SERS） detection technology enhances "fingerprint" information of tested substance by adsorbing it on the surface of SERS substrate to achieve trace detection. With the advantages of simple pre-processing, high sensitivity, simple operation, real-time non-destructive detection on site and so on, SERS analysis technology has attracted much attention in food safety rapid detection. The characteristics and limitations of various types of SERS substrates were introduced. The recent research on SERS detection technology in food safety detection was summarized in detail. Finally, this paper discussed the challenges of its commercial application, and prospected the …

Research Progress Of Plant Exosome-Like Nanoparticles On Characteristics, Components And Functions, Chen Chunping, Xu Hongyan, Liu Shuaichen, Tian Yuxin, Wang Yuchen

Food and Machinery

Exosome-like nanoparticles （ELNs） are nano-sized extracellular vesicles enclosed by lipid bilayer membrane and secreted by cells; And carrying a variety of cargo, including lipids, proteins, miRNAs and secondary metabolites. Plant ELNs have received widespread attention due to their unique structure and excellent physiological activity. This review summarizes the isolation methods, characteristics, components and functions of plant ELNs, focusing on the application of multi-omics technologies in plant ELNs. In addition, some suggestions for further study of plant ELNs were put forward.

Metabolic Collaboration Between Cells In The Tumor Microenvironment Has A Negligible Effect On Tumor Growth, Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen

Department of Biochemistry: Faculty Publications

The tumor microenvironment is composed of a complex mixture of different cell types interacting under conditions of nutrient deprivation, but the metabolism therein is not fully understood due to difficulties in measuring metabolic fluxes and exchange of metabolites between different cell types in vivo. Genome-scale metabolic modeling enables estimation of such exchange fluxes as well as an opportunity to gain insight into the metabolic behavior of individual cell types. Here, we estimated the availability of nutrients and oxygen within the tumor microenvironment using concentration measurements from blood together with a metabolite diffusion model. In addition, we developed an approach …

Mapping Selected Emergent Marine Toxin-Producing Organisms Using Historical Samples With Two Methods (Biosensors And Real-Time Pcr): A Comparison Of Resolution, Gerado Mengs, Rowena F. Stern, Jessica L. Clarke, Matthew Faith, Linda K. Medlin

School of Biological and Marine Sciences

The Continuous Plankton Recorder (CPR) survey is a valuable resource for mapping changes in plankton distribution and understanding harmful algal ecology because of its breadth and longevity. Preservation methods with formalin degrade DNA, making it difficult to use as a molecular tool for archived marine samples. DNA was extracted from CPR samples immediately after collection, seven months later and after nine years of storage from a cruise track along the Iberian Peninsula. PCR reactions performed from the nine-year timepoint were hybridized to probes in an electrochemical biosensor and compared to results obtained from RT-PCR performed at two earlier time points. …

Nest/Ing: An Emergent (Un)Methodology For Becoming Otherwise, Jayne Osgood, Claire Walsh

School of Law, Humanities and Social Sciences

A dense, pungent, brown-green, intricately woven, itchy-silky, moss-strewn, twig- ridden ball brought us together.Since then, nest(ing)[i] has become a shared methodology - nest/ing has offered a praxis of getting to know each other, getting to know nests (better) and it has become a capacious writing methodology. Taking nest(ing) seriously has drawn into sharp focus the perils of human exceptionalism. Nesting has gifted opportunities to wallow in porous boundaries and to luxuriate in modes of liminal reading/writing/experimenting, informed by a feminist politics to imagine the world differently (Despret, 2016). It is through lively storytelling, involving passing patterns back and forth that …

Continuous Preparation Of Antioxidant Low Molecular Weight Hyaluronic Acid By Coupling Of Enzymolysis And Membrane Separation, Teng Wei, Liu Junhui, Wu Jinhong, Liu Shutao

Food and Machinery

Objective: This study aimed to construct an enzymolysis and membrane separation method to improve the production efficiency of low molecular hyaluronic acid (HA). Methods: A continuous enzymolysis and membrane separation coupling reaction system was designed, which consisted of an enzyme biological reaction tank and a flat polyethersulfone ultrafiltration membrane separation module. By evaluating membrane flux, membrane contamination, hyaluronic acid concentration, and yield, the effects of various factors on the separation of low molecular HA in the enzyme-membrane coupling system were systematically investigated. The process parameters of the enzyme-membrane coupling reaction were further optimized through orthogonal experiments. Results: The optimal process …

The Influence Of Stacking Mode And Air Supply Power On Cooling Effect Of Cold Storage, Xu Jing, Wang Feng, Tan Zhenhua, Lu Qiufang

Food and Machinery

Objective: Reasonable planning of the stacking of goods in the mobile cold storage and reasonable design of the air supply power of the fan, to reduce cold storage energy consumption and improve economic efficiency. Methods: A three-dimensional physical model and k-ε mathematical model of a certain cold storage were established, and the temperature field inside the cold storage under different stacking methods of goods and different air supply power were simulated using Fluent software. Results: The research results showed that under the same working conditions, the average storage temperature of goods horizontally was 2.014 ℃, and the average storage temperature …