Digital Commons Network^™

Some Free Boundary Problem Arising In Rock Mechanics, Anvarbek Meirmanov, Koblandy Yerzhanov

Turkish Journal of Mathematics

An initial boundary value problem for the in-situ leaching of rare metals with the acid solution in the elastic skeleton is considered. First, we describe physical processes at the microscopic level with a dimensional pore size [[EQUATION]]1 by the model [[EQUATION]], where dynamics of the incompressible solid skeleton is described by the Lamé equations and the physical process in the pore space by the Stokes equations for the incompressible fluid in combination with the diffusion and transport equations for the concentration of acid and product of chemical reactions. Since the solid skeleton changes its geometry upon dissolution, the “pore space …

Some Complementary Results On Asymptotic Behavior Of Solutions Of Neutral Difference Equations, Nour H. M. Alsharif, Başak Karpuz

Turkish Journal of Mathematics

This paper focuses on examining the boundedness and asymptotic behavior of all solutions of the neutral difference equations\begin{equation}\Delta[x_{n}-p_{n}x_{n-\kappa}]+q_{n}x_{n-\ell}=0\quad\text{for}\ n=0,1,\cdots,\label{abseq1}\tag{$\star$}\end{equation}and\begin{equation}\Delta[x_{n}-px_{n-\kappa}]+q_{n}x_{n-\ell}=0\quad\text{for}\ n=0,1,\cdots,\label{abseq2}\tag{$\star\star$}\end{equation}where $\kappa,\ell\in\N$, $\{p_{n}\}\subset[0,1)$, $p\in[0,1)$ and $\{q_{n}\}\subset[0,\infty)$.Diverging from much of the existing literature, our results accommodate the scenario where$\{p_{n}\}\subset[\frac{1}{2},1)$ and $p\in[\frac{1}{2},1)$ for \eqref{abseq1} and \eqref{abseq2}, respectively.Furthermore, we underscore the practical implications of our results through the presentation of numerical examples. This paper focuses on examining the boundedness and asymptotic behavior of all solutions of the neutral difference equations \begin{equation} \Delta[x_{n}-p_{n}x_{n-\kappa}]+q_{n}x_{n-\ell}=0\quad\text{for}\ n=0,1,\cdots,\label{abseq1}\tag{$\star$} \end{equation} and \begin{equation} \Delta[x_{n}-px_{n-\kappa}]+q_{n}x_{n-\ell}=0\quad\text{for}\ n=0,1,\cdots,\label{abseq2}\tag{$\star\star$} \end{equation} where $\kappa,\ell\in\N$, $\{p_{n}\}\subset[0,1)$, $p\in[0,1)$ and $\{q_{n}\}\subset[0,\infty)$. Diverging from much of the existing literature, our results …

Creatine And Depression In Rodents: A Meta-Analysis, Ruchika S. Tirupachur

Master's Theses

Traditional treatments for major depression are based on the monoamine deficiency hypothesis, and they fail to achieve remission in a substantial portion of patients. Newer evidence suggests the pathophysiology of depression is a more complex story, highlighting a need for research in alternative therapies. Mounting evidence shows a linkage between depression and the supplement creatine monohydrate (CRMH). Research in rodent models suggests that CRMH may both alleviate depressive symptoms and enhance the efficacy of standard antidepressants like SSRIs. The following study describes findings from a combined fixed- and random-effects meta-analysis based on four empirical studies investigating the effect of CRMH …

Using Moss As An Inexpensive Air Pollution Bioindicator For Environmental Equity In Santa Clara Country, California, Tam Dan Tran

Master's Theses

Toxins pervade urban areas and pose long-term health risks to humans. I examine moss as an affordable bioindicator and assess whether moss monitor results reflect other air quality (AQ) indicators, environmental factors, and social vulnerability. Specifically, I investigate (1) whether moss is an effective atmospheric pollution indicator and (2) whether low-income or high-lead-risk neighborhoods experience greater exposure to air pollution. I set out Hypnum cupressiforme moss for two months of exposure in 28 Santa Clara County locations and then measured chromium, zinc, nickel, and the loss of chlorophyll fluorescence in the moss tissue. I gathered real-time particulate matter (PM2.5) measurements …

Mammal Response To Wildfire In Redwood Forests In Northern California, Kristine Doerr

Master's Theses

California has historically experienced recurrent wildfires that have shaped many of the region’s unique ecosystems such as coast redwood (Sequoia sempervirens) forests. Redwood forests, particularly old-growth redwoods, are vital habitats for many wildlife species. Still, these long-living, fire-resistant trees are facing altered fire regimes due to fire suppression and climate change. The 2020 CZU Lightning Complex Fire was a consequence of these changes and significantly altered the landscape of the Santa Cruz Mountain region. This study analyzes mammal recovery after wildfire in high and low fire severity locations of the CZU Fire using two camera trap grids. The high-severity grid …

A Trailside Study Of A Coast Redwood Forest Understory Specis, Trillium Ovatum, In The Santa Cruz Mountains, Mary Yan

Master's Theses

To fully understand one of the world’s greatest terrestrial carbon sinks, the coast redwood forest, a co-occurring species may be the key to unique and accessible opportunities to collectively monitor the health of this important habitat. I investigated the relationship between hiking trails and Trillium ovatum within the redwood forests of three California State Parks. Utilizing quadrats across 115 one-meter plots and 58 10-meter transects, T. ovatum occurrence and abundance were recorded and analyzed with factors including proximity to trails, distance from streams, elevation, slope, canopy cover, duff depth, co-occurring understory species, and tree species dominance. Results indicated a higher …

Win-Win Ecology: Can Mosses Promote Dudleya Germination To Restore California Quarries?, Kate L. Worrell

Master's Theses

Human actions directly damage habitat for native plants; restoration ecology facilitates successful plant re-establishment in these environments. Open-pit mines leave behind steep, rocky, and nutrient-deficient habitats that are some of the most degraded ecosystems on the planet. Dudleya or ‘live-forevers’— a genus of native California succulent plants that contains many rare, threatened, or endangered species — grow on rocky cliffs and may create a successful reclamation-restoration story. However, Dudleya germination is poorly understood. Much of the literature on Dudleya cites a single field report suggesting that bryophytes facilitate germination, but no previous experiments have evaluated this proposal. In this study, …

An Assessment Of Anthropogenic Injuries On White Sharks (Carcharodon Carcharias) In Central California, Kaitlyn Yee

Master's Theses

As human activities increasingly impact marine ecosystems, understanding the effects of anthropogenic activity on white sharks is important for their continued conservation. Human-induced injuries are observed in many shark species. Such injuries have been found to have physiological and ecological impacts. Four sites in Central California off the coasts of Aptos, Año Nuevo Island, Southeast Farallon Island, and Point Reyes are all known areas of white shark aggregation with varying levels of human use and protection. Utilizing a vast video database, this study evaluated the effects of natural and non-natural anthropogenic shark injury types across all locations, age classes, and …

Swim Bladder Morphology Influences The Responses Of Nearshore Rockfishes To Barotrauma, Molly K. Alvino

Master's Theses

Rockfishes (Sebastes spp.) are ecologically and economically important fishes in the continental shelf and slope regions of the Eastern Pacific Ocean. All species within the Sebastes genus have a buoyancy organ, the swim bladder, which is sensitive to rapid changes in pressure that occur when fish are caught and brought up to the surface. Although all rockfishes have swim bladders, pressure-related injuries (barotrauma) affect rockfish species differently. I determined whether swim bladder morphology can explain differences in barotrauma among semi-pelagic (Blue and Olive rockfish) and benthic (Gopher and Vermilion rockfish) species that occupy different habitat zones. Seven different swim bladder …

Best Practices For The Naming Of Species, Luis A. Ruedas, Ryan W. Norris, Robert M. Timm

Biology Faculty Publications and Presentations

The process of describing a species has evolved considerably since the modern age of taxonomy was initiated with the publication of the 10th edition of Linnaeus’ Systema Naturæ in 1758. Nevertheless, the basic unit of the taxonomic framework remains the species group (species and subspecies). As a result, it is incumbent upon individuals undertaking species-group descriptions to strive for the highest standards, just as it is for reviewers and editors to hold authors to those same standards. The clear and mounting biodiversity crisis, the increasing proliferation of journals, the multiplication of journals publishing only in electronic format, the decline in …

Chasing A Little-Known Fairy Bee (Perdita Meconis) In A Dynamic Desert Landscape, Sarit Chanprame, Colleen Meidt, Terry Griswold, Joseph S. Wilson, Kelsey K. Graham

Biology Student Research

The Mojave poppy bee, Perdita meconis Griswold, is a small fairy bee endemic to the eastern Mojave Desert, known to be associated with the Las Vegas Bearpoppy, Arctomecon californica. Because of the reported decline in populations of P. meconis, it has been targeted for protection under the Endangered Species Act. Here, we present the results of a 3-year study investigating the current distribution and floral preferences of P. meconis in Clark County, Nevada. We found that populations of P. meconis fluctuated dramatically from 2020 to 2022. This area experienced extreme drought conditions during these years, which consequentially affected …

Investigation Of Trimethylenemethane Cyclopentyl-Annulations As A Strategy To Obtain A Functionalized Angular Triquinane Skeleton †, S. M. Webber, Wade A. Russu

Pacific Faculty Work

The angular triquinane carbocyclic ring system is a component of many natural products found in numerous terrestrial and marine plants. A strategy for the synthesis of functionalized angular triquinanes utilizing two trimethylenemethane (TMM)-based [3+2] cycloaddition reactions is presented. This synthetic strategy employs the intermolecular dyil-trapping reaction to give eventual access to the bicyclo[3.3.0]oct-1-en-3-one system. A subsequent [3+2] cycloaddition with a TMM equivalent provides the angular triquinane carbocyclic framework.

Intersections Of Living And Machine Agencies: Art-Based Models Of Adaptive Conversation With The More-Than-Human World, Carlos Castellanos

Tradition Innovations in Arts, Design, and Media Higher Education

Today’s AI systems are not built to have reciprocal interplay with their environments and thus they demonstrate little interest in emergence, adaptation or developing mutually productive relationships with the natural world. Is a different kind of AI possible? How can artists contribute to its development? In this essay, I will discuss ways in which the arts might help guide us towards a new kind of AI, built upon adaptive conversation (i.e. shared construction of meaning) with nature. I will discuss how can work with AI while also challenging its prevailing ontology, and even suggest alternative ontologies and epistemologies. I will …

Montana Kaimin, November 14, 2024, Students Of The University Of Montana, Missoula

Montana Kaimin, 1898-present

Student newspaper of the University of Montana, Missoula.

Systematic Review Of Immune Checkpoint Inhibitor-Related Gastrointestinal, Hepatobiliary, And Pancreatic Adverse Events, Malek Shatila, Hao Chi Zhang, Anusha Shirwaikar Thomas, Antonio Pizuorno Machado, Sidra Naz, Nitish Mittal, Christine Catinis, Krishnavathana Varatharajalu, Carolina Colli Cruz, Eric Lu, Deanna Wu, Julie R Brahmer, Franck Carbonnel, Stephen B Hanauer, Bret Lashner, Bryan Schneider, John A Thompson, Michel Obeid, David P Farris, Yinghong Wang

Faculty, Staff and Student Publications

Gastrointestinal immune-related adverse events (GI irAEs) are common manifestations of immune checkpoint inhibitor (ICI) toxicity. We present a comprehensive systematic review of the incidence, management, and clinical course of irAEs across the entire GI system, including the luminal GI tract, liver, and pancreas. MEDLINE, Embase, Web of Science Core Collection, and Cochrane Library were used to conduct this review. All studies pertaining to GI irAEs were included. Both abstracts and full manuscripts were eligible if they included human subjects and were written in the English language. Articles not available in English, animal studies, or research not specific to GI toxicity …

Moment-Based Approximation For Variance Of Semi-Markovian Random Walk With Gamma Distributed Interference Of Chance, Büşra Alakoç, Asli Bektaş Kamişlik, Tülay Yazir, Tahi̇r Khaniyev

Turkish Journal of Mathematics

This study proposed moment-based approximations for the expected value and variance of the ergodic distribution of the semi-Markovian random walk process (X(t)) with gamma distributed interference of chance. Many studies have investigated analogous moment problems by using asymptotic approach. The key distinguishing aspect of this study from others in the literature is obtaining Kambo’s approximations for the moments of X(t) instead of asymptotic expansions. Firstly, the approximation formulas for the moments of boundary functional SN(z) of X(t) were obtained. Then using these results, approximation formulas for the first two moments of the ergodic distributions of X(t) were derived. Finally, the …

Numerical Solutions Of Sird Model Of Covid-19 By Utilizing Pell-Lucascollocation Method, Gamze Yildirim, Şuayi̇p Yüzbaşi

Turkish Journal of Mathematics

This article presents an SIRD model based on the evolution of Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV-2 from the coronavirus family. Firstly, we constitute Pell-Lucas collocation method (PLCM) for this model. According to method, the matrix forms of the Pell-Lucas polynomials (PLPs) are constituted. By utilizing this matrix forms, solution forms and all terms in this model are expressed in matrix form. Thus, PLCM transforms our model into a system of the matrix equations. By solving this system, the approximate solutions are obtained. In addition, the error analysis is also presented. In the examples of this study, we analyzed …

Conference Report: Review Of Clinical Implementation Of Advanced Quantitative Imaging Techniques For Personalized Radiotherapy, Yevgeniy Vinogradskiy, Houda Bahig, Nicholas Bucknell, Jeffrey Buchsbaum, Hui-Kuo George Shu

Department of Radiation Oncology Faculty Papers

The topic of quantitative imaging in radiation therapy was presented as a "Masterclass" at the 2023 annual meeting of the American Society of Radiation Oncology (ASTRO). Dual-energy computed tomography (CT) and single-positron computed tomography were reviewed in detail as the first portion of the meeting session, with data showing utility in many aspects of radiation oncology including treatment planning and dose response. Positron emission tomography/CT scans evaluating the functional volume of lung tissue so as to provide optimal avoidance of healthy lungs were presented second. Advanced brain imaging was then discussed in the context of different forms of magnetic resonance …

Oncolytic Virotherapies And Adjuvant Gut Microbiome Therapeutics To Enhance Efficacy Against Malignant Gliomas, Natalie M Meléndez-Vázquez, Candelaria Gomez-Manzano, Filipa Godoy-Vitorino

Faculty, Staff and Student Publications

Glioblastoma (GBM) is the most prevalent malignant brain tumor. Current standard-of-care treatments offer limited benefits for patient survival. Virotherapy is emerging as a novel strategy to use oncolytic viruses (OVs) for the treatment of GBM. These engineered and non-engineered viruses infect and lyse cancer cells, causing tumor destruction without harming healthy cells. Recent advances in genetic modifications to OVs have helped improve their targeting capabilities and introduce therapeutic genes, broadening the therapeutic window and minimizing potential side effects. The efficacy of oncolytic virotherapy can be enhanced by combining it with other treatments such as immunotherapy, chemotherapy, or radiation. Recent studies …

Exploring The Role Of Tissue-Resident T Cells In Neurotropic Viral Infections And Opioid-Induced Immune Disorders During Exposure And Withdrawal, Shenjian Ai

Arts & Sciences Graduate Student Theses and Dissertations

Tissue-resident T cells play a crucial role in the immune response to neurotropic viral infections and opioid-induced immune disorders. Understanding the roles of tissue-resident T cells in these contexts is essential for developing therapeutic strategies to mitigate their detrimental effects while enhancing their protective functions. The chemokine receptor CXCR6 and its ligand CXCL16 are critical in maintaining the population of tissue-resident T cells in the CNS. CXCR6 is expressed on CD8 T cells that persist in the CNS after recovery from West Nile virus infection. Research has shown that CXCL16, produced by microglia and other myeloid cells, binds to CXCR6 …

The Effects Of Full-Body Photo-Editing On Female Body Image, Claire E. Mcelhern

Master's Theses

Over the past decade, the use of photo-based social media sites has seen an exponential increase. Although these sites can be beneficial for connecting with others, the editing and modification of images posted to social media has also produced adverse effects on some who use them. The aim of the present study was to assess whether partaking in a full-body photo-editing task would have a significant effect on weight dissatisfaction, appearance dissatisfaction and body confidence, compared to a control condition. Female college participants were first asked about their general Instagram use, and then were given a baseline Visual Analog Scale …

No Change In Functional Ecology Or Body Size In Response To A Global Climate Event In The Late Maastrichtian Owl Creek Formation, William T. Rizza

Master's Theses

During the last 300 ka of the Maastrichtian, global temperatures increased and decreased by ~2℃, likely caused by a pulse of Deccan volcanism. The Owl Creek Type Section in Mississippi records some portion of the last 400 ka of the Late Maastrichtian. It is expected that marine invertebrates will demonstrate a taxonomic, ecological, or morphological response to rapid temperature change. I anticipate a decrease in taxonomic diversity and shell volume and an increased abundance of low activity-level species, similar to the ecological impacts observed in response to Large Igneous Province eruptions in the geologic record. Clumped isotope paleotemperature reconstruction recovers …

Exploring In-Service Science Teachers' Self-Perceptions Of Competence And Pedagogical Approaches To Socioscientific Issues In Education, Arberore Bicaj, Fatlume Berisha, Rachel Gisewhite

Faculty Publications

Global education experts are increasingly prioritizing scientific literacy development. Science education is key to enhancing scientific literacy, fostering social responsibility, and supporting economic growth by equipping individuals with essential scientific knowledge and skills. In the past two decades, socioscientific issues (SSI) have greatly influenced science education research, improving students’ ability to apply scientific knowledge in real-world contexts and advancing functional scientific literacy. Given the strong evidence that socioscientific issues (SSI) enhance scientific literacy and social responsibility skills, understanding SSI role in science education is crucial for developing countries aiming to boost economic and social growth. This research aimed to understand …

Transitions Into Freezing Environments Linked With Shifts In Phylogenetic Integration Between Vitaceae Leaf Traits, Charles Tomo Parins-Fukuchi, Gregory W. Stull, Jun Wen, Jeremy M. Beaulieu

Biological Sciences Faculty Publications and Presentations

Understanding how the intrinsic ability of populations and species to meet shifting selective demands shapes evolutionary patterns over both short and long timescales is a major question in biology. One major axis of evolutionary flexibility can be measured by phenotypic integration and modularity. The strength, scale, and structure of integration may constrain or catalyze evolution in the face of new selective pressures. We analyze a dataset of seven leaf measurements across Vitaceae to examine how correlations in trait divergence are linked to transitions between freezing and nonfreezing habitats. We assess this by applying a custom algorithm to compare the timing …

Evidence That Crispr-Cas9 Y537s-Mutant Expressing Breast Cancer Cells Activate Yes-Associated Protein 1 To Driving The Conversion Of Normal Fibroblasts Into Cancer-Associated Fibroblasts, Luca Gelsomino, Amanda Caruso, Emine Tasan, Adele Elisabetta Leonetti, Rocco Malivindi, Giuseppina Daniela Naimo, Francesca Giordano, Salvatore Panza, Guowei Gu, Benedetta Perrone, Cinzia Giordano, Loredana Mauro, Bruno Nardo, Gianfranco Filippelli, Daniela Bonofiglio, Ines Barone, Suzanne A W Fuqua, Stefania Catalano, Sebastiano Andò

Faculty, Staff and Students Publications

BACKGROUND: Endocrine therapy (ET) has improved the clinical outcomes of Estrogen receptor alpha-positive (ERɑ +) breast cancer (BC) patients, even though resistance to ET remains a clinical issue. Mutations in the hormone-binding domain of ERɑ represent an acquired intrinsic mechanism of ET resistance. However, the latter also depends on the multiple functional interactions between BC cells and the tumor microenvironment (TME). Here, we investigated how the most common Y537S-ERɑ mutation may influence the behavior of fibroblasts, the most prominent component of the TME.

METHODS: We conducted coculture experiments with normal human foreskin fibroblasts BJ1-hTERT (NFs), cancer-associated fibroblasts (CAFs), isolated from …

Pvacview: An Interactive Visualization Tool For Efficient Neoantigen Prioritization And Selection, Huiming Xia, My H Hoang, Evelyn Schmidt, Susanna Kiwala, Joshua Mcmichael, Zachary L Skidmore, Bryan Fisk, Jonathan J Song, Jasreet Hundal, Thomas Mooney, Jason R Walker, S Peter Goedegebuure, Christopher A Miller, William E Gillanders, Obi L Griffith, Malachi Griffith

2020-Current year OA Pubs

BACKGROUND: Neoantigen-targeting therapies including personalized vaccines have shown promise in the treatment of cancers, particularly when used in combination with checkpoint blockade therapy. At least 100 clinical trials involving these therapies have been initiated globally. Accurate identification and prioritization of neoantigens is crucial for designing these trials, predicting treatment response, and understanding mechanisms of resistance. With the advent of massively parallel DNA and RNA sequencing technologies, it is now possible to computationally predict neoantigens based on patient-specific variant information. However, numerous factors must be considered when prioritizing neoantigens for use in personalized therapies. Complexities such as alternative transcript annotations, various …

The Relationship Between Spectral Signals And Retinal Sensitivity In Dendrobatid Frogs, Whitney G. Walkowski, Corinne L. Richards-Zawacki, William C. Gordon, Nicolas G. Bazan, Hamilton E. Farris

School of Graduate Studies Faculty Publications

Research on visually driven behavior in anurans has often focused on Dendrobatoidea, a clade with extensive variation in skin reflectance, which is perceived to range from cryptic to conspicuous coloration. Because these skin patterns are important in intraspecific and interspecific communication, we hypothesized that the visual spectral sensitivity of dendrobatids should vary with conspecific skin spectrum. We predicted that the physiological response of frog retinas would be tuned to portions of the visible light spectrum that match their body reflectance. Using wavelength-specific electroretinograms (ERGs; from 350-650 nm), spectrometer measurements, and color-calibrated photography of the skin, we compared retinal sensitivity and …

Vol. 40, No. 7 - Whole No. 256, Eleanor M. Farrell

Mythprint

Mythprint is the monthly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local and written discussion groups.

Identification Of Nitro-Containing Compounds As Potent Inhibitors Of Glioblastoma Stem Cells Via Stat3 Pathway Suppression, Matthew Pate, Roberto Martin, Emma Baker, Blake Hutchins, Marie J. Moreno Hollweg, Sabrin Safar, Kyuree Chang, Eduardo A. Veliz, Steven Vanni, Regina Graham

HCA-NSU MD Research Day

Identification of Nitro-Containing Compounds as Potent Inhibitors of Glioblastoma Stem Cells via STAT3 Pathway Suppression Matthew C. Pate1, Roberto Martin2, Emma Baker1, Blake Hutchins1, Maria Moreno Hollweg1, Sabrin Safar1, Kyuree Chang1, Eduardo A. Veliz PhD3, Steven Vanni DO 1,4, Regina M. Graham PhD1 1Nova Southeastern University Dr. Kiran C Patel College of Allopathic Medicine, Fort Lauderdale, FL, USA, 2Nova Southeastern University Dr. Kiran C Patel College of Osteopathic Medicine, Fort Lauderdale, FL, USA, 3Department of Chemistry, University of Miami, Coral Gables, FL, USA ,4HCA Florida University Hospital, Davie, FL, USA, Objective: To examine cytotoxic effects of a series of nitro-compounds …

Towards An Ideal Seed Coating, J M. Scott

IGC Proceedings (1977-2023)

Coated pasture seeds have been formulated in the past based largely on "trial and error" with relatively few objective criteria being employed to define desirable formulations, A description of desirable propelties of various layers of seed coatings and of the seeds themselves is presented.