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2024

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Walking Through An Idea, Bill Mckibben Nov 2024

Walking Through An Idea, Bill Mckibben

Appalachia

There's no place untouched by humans, but we must preserve the "relative wild."


Relocalizing Food Sovereignty And Peace-Making: Lessons From The Covid-19 Pandemic, Rainier A. Ibana Nov 2024

Relocalizing Food Sovereignty And Peace-Making: Lessons From The Covid-19 Pandemic, Rainier A. Ibana

Budhi: A Journal of Ideas and Culture

Relocalizing Food Sovereignty and Peace-Making: Lessons from the COVID-19 Pandemic


Berries In Baskets Versus Apples In Crates: Arguing For Ecocentrism In A Post-Covid World, Abhik Gupta Nov 2024

Berries In Baskets Versus Apples In Crates: Arguing For Ecocentrism In A Post-Covid World, Abhik Gupta

Budhi: A Journal of Ideas and Culture

The global outbreak of COVID-19 has raised questions about human relationships with nature vis-à-vis development models that are largely followed worldwide. Conservation biologist Raymond F. Dasmann introduced the concept of “ecosystem people” to describe predominantly rural communities who largely depend on the resources available in one or a few ecosystems around them. These societies are also characterized by their close relationships with nature and their ecocentric worldviews. However, the world today is dominated by “biosphere people” who populate the urban areas and typically use resources extracted from all over the world. This biosphere model of existence has also given rise …


Relational Egalitarianism And The Covid-19 Pandemic, Jacqueline Marie J. Tolentino Nov 2024

Relational Egalitarianism And The Covid-19 Pandemic, Jacqueline Marie J. Tolentino

Budhi: A Journal of Ideas and Culture

The current COVID-19 pandemic has called for unprecedented measures to contain it and, as such, has reinforced and produced complex and intertwining health and non-health inequalities. I take the perspective of relational egalitarianism and argue that these inequalities are not only issues of public health and economics but also of social justice. I thus aim to construct a relational egalitarian framework to examine how and why the inequalities of COVID-19 are unjust and to work out what structural changes and processes might be required to justly respond to these inequalities.


Normalizing The Population: The Biopolitics Of The "New Normal", Federico José T. Lagdameo Nov 2024

Normalizing The Population: The Biopolitics Of The "New Normal", Federico José T. Lagdameo

Budhi: A Journal of Ideas and Culture

While the whole world is trying to get its bearings in the face of the radical changes brought about by the COVID-19 pandemic, two prevailing attitudes or approaches have emerged: (1) a yearning for a return to pre-COVID-19 normalcy typified by what I call the “typhoon-shelter approach” and (2) recognizing the irreversibility of the current condition and seeking to establish a “new normal.” The biopolitical analysis employed in this paper reveals unintended consequences that slip through the mesh of traditional forms of critique centered on capital, ideology, or class conflict. Specifically, the “new normal” project prevents the free movement of …


A Peak Ahead: Fear, Christine Woodside Nov 2024

A Peak Ahead: Fear, Christine Woodside

Appalachia

No abstract provided.


The Color Of Water: Whitewater Canoeing On A Tennessee River That Once Was The Shade Of Strong Tea, John Manuel Nov 2024

The Color Of Water: Whitewater Canoeing On A Tennessee River That Once Was The Shade Of Strong Tea, John Manuel

Appalachia

No abstract provided.


Accumbal Plasticity And Associated Behavioral Adaptations In The Spared Nerve Injury Model Of Chronic Neuropathic Pain, Yu-Hsuan Chang Nov 2024

Accumbal Plasticity And Associated Behavioral Adaptations In The Spared Nerve Injury Model Of Chronic Neuropathic Pain, Yu-Hsuan Chang

Arts & Sciences Electronic Theses and Dissertations

Chronic pain is a debilitating neurological disorder that affects hundreds of millions of individuals worldwide. It is associated with cognitive symptoms such as cognitive inflexibility, which is defined as the inability to adaptively update behavior in response to changing environmental conditions. To date, there are no effective treatments for these symptoms, even though they substantially contribute to the decreased quality of life of chronic pain patients and are associated with reduced efficacy of pain management strategies. Therefore, understanding the neural circuit adaptations that drive cognitive symptoms of chronic pain, like cognitive inflexibility, is essential for improving existing treatments for this …


First Records Of The Spider Wasp Entypus Ochrocerus Dahlbom (Hymenoptera: Pompilidae: Pepsinae) From The Continental United States, Jamaica, And The Bahamas, Frank E. Kurczewski, Rick C. West, Dionne Newell, Scott Johnson Nov 2024

First Records Of The Spider Wasp Entypus Ochrocerus Dahlbom (Hymenoptera: Pompilidae: Pepsinae) From The Continental United States, Jamaica, And The Bahamas, Frank E. Kurczewski, Rick C. West, Dionne Newell, Scott Johnson

Insecta Mundi

A small population of Entypus ochrocerus Dahlbom, a predominantly Greater Antilles spider wasp (Hymenoptera: Pompilidae: Pepsinae), is reported for the first time from the continental United States based on photographs and associated information from iNaturalist.org. The species was initially misidentified online as E. unifasciatus unifasciatus (Say) or Entypus sp. However, Entypus u. unifasciatus individuals from east of the 100th Meridian in the United States typically have melanochromatic (dark) wings with a subapical xanthochromatic (orange-amber) patch. Entypus ochrocerus from Miami-Dade County, Florida is differentiated from E. u. unifasciatus by its black body with dark greenish blue reflections …


First Record Of The Mexican-M Hairstreak Parrhasius Moctezuma (Clench, 1971) (Lepidoptera: Lycaenidae) In Texas, Usa, And Possible Sighting Of The Tequila Giant Skipper Aegiale Hesperiaris (Walker, 1856) (Lepidoptera: Hesperiidae), Sajan Kc, Anisha Sapkota Nov 2024

First Record Of The Mexican-M Hairstreak Parrhasius Moctezuma (Clench, 1971) (Lepidoptera: Lycaenidae) In Texas, Usa, And Possible Sighting Of The Tequila Giant Skipper Aegiale Hesperiaris (Walker, 1856) (Lepidoptera: Hesperiidae), Sajan Kc, Anisha Sapkota

Insecta Mundi

We report two significant butterfly sightings in the United States, observed during an opportunistic photographic survey conducted in south Texas between December 2022 and January 2023. Parrhasius moctezuma (Clench, 1971) (Lepidoptera: Lycaenidae) was sighted at the National Butterfly Center in Mission, Texas on January 5, 2023, marking the first documented record of the species in Texas and only the second in the United States, as confirmed by photographic evidence. Additionally, Aegiale hesperiaris (Walker, 1856) (Lepidoptera: Hesperiidae) was potentially observed at the same location on December 4, 2022, although lacking photographic documentation or a collected specimen, highlighting the need for further …


The Puzzling Distribution Of Platphalonidia Aenigmana, New Species, From The Western U. S. A. And Colombia (Lepidoptera: Tortricidae: Cochylina), John W. Brown Nov 2024

The Puzzling Distribution Of Platphalonidia Aenigmana, New Species, From The Western U. S. A. And Colombia (Lepidoptera: Tortricidae: Cochylina), John W. Brown

Insecta Mundi

Platphalonidia aenigmana Brown, new species (Lepidoptera: Tortricidae), is described and illustrated from Arizona, California, and Oregon, U. S. A. and Colombia, South America. The new species has been reared on numerous occasions from Garrya elliptica Dougl. ex Lindl. (Garryaceae) in northern California and Oregon, once on Arctostaphylos sp. (Ericaceae) in southern California, and once on Gomphrena globosa L. (Amaranthaceae) in Colombia. Various hypotheses are explored to explain the unusual disjunct geographic distribution of the species. In addition, Phalonidia bassii Razowski (Tortricidae) is transferred to Saphenista Walsingham, resulting in Saphenista bassii (Razowski, 1999), new combination.


A New Species Of Cymatodera Gray (Coleoptera: Cleridae) From Central Arizona, Jacques Rifkind Nov 2024

A New Species Of Cymatodera Gray (Coleoptera: Cleridae) From Central Arizona, Jacques Rifkind

Insecta Mundi

Cymatodera campbelli, new species (Coleoptera: Cleridae), is described from central Arizona, United States. Though superficially similar to several other small species of Southwestern Cymatodera Gray that are commonly collected at lights, this apparently rare species has distinctive coloration and surface sculpturing. Its discovery suggests that systematic collecting even in areas that have historically attracted entomological attention may still yield additions to our fauna.


New Country Records For Macroscython Granulosus Otto, 2016 (Coleoptera: Eucnemidae: Dromaeolinae: Dromaeolini), With Redescription Of The Female, Robert L. Otto, Jiří Háva Nov 2024

New Country Records For Macroscython Granulosus Otto, 2016 (Coleoptera: Eucnemidae: Dromaeolinae: Dromaeolini), With Redescription Of The Female, Robert L. Otto, Jiří Háva

Insecta Mundi

New country records for Macroscython granulosus Otto, 2016 (Coleoptera: Eucnemidae: Dromaeolinae: Dromaeolini), a eucnemid known only from Laos and Thailand, are reported from China and Nepal. A redescription and images of the female are provided.


Genomic Analysis Reveals Hidden Species Diversity In Emesis Fabricius (Lepidoptera: Riodinidae), Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin Nov 2024

Genomic Analysis Reveals Hidden Species Diversity In Emesis Fabricius (Lepidoptera: Riodinidae), Jing Zhang, Qian Cong, Jinhui Shen, Leina Song, Nick V. Grishin

Insecta Mundi

Genomic analysis of Emesis [Fabricius], 1807 (Lepidoptera: Riodinidae Grote, 1895) reveals species richness higher than anticipated. As a result, one subgenus, 22 species, and one subspecies are proposed as new (type species or type localities in parenthesis): Diogenia Grishin, new subgenus (Emesis diogenia Prittwitz, 1865), Emesis (Emesis) aerunda Grishin, new species (Peru: Rio Pachitea, Monte Alegre), Emesis (Emesis) bartica Grishin, new species (Guyana: Cuyuni-Mazaruni), Emesis (Emesis) fatimellina Grishin, new species (Brazil: Santa Catarina), Emesis (Emesis) panamella Grishin, new species (Panama: Darién), Emesis (Mandania) mandora Grishin, new species (Ecuador: …


Review Of Nealyda Dietz (Lepidoptera: Gelechiidae: Apatetrinae) With Description Of A New Species From The Florida Keys, Sidney V. Bennett, James E. Hayden Nov 2024

Review Of Nealyda Dietz (Lepidoptera: Gelechiidae: Apatetrinae) With Description Of A New Species From The Florida Keys, Sidney V. Bennett, James E. Hayden

Insecta Mundi

Nealyda grandipinella Bennett and Hayden, new species, is described from Big Pine Key, Florida, USA. Photographs of the adult and of male and female genitalia are provided for N. grandipinella and its congeners within the state of Florida. Nealyda Dietz (Lepidoptera: Gelechiidae) is provisionally transferred from Anomologinae to Apatetrinae based on characters of the genitalia. The homology and terminology of the processes arising from the vinculum of gelechiid genitalia are explored. The potential host plant of the new species is discussed, along with other undescribed species of Nealyda.


First Record Of The Camphor Shot Borer, Cnestus Mutilatus (Blandford) (Coleoptera: Curculionidae: Scolytinae), In Massachusetts, Lawrence E. Barringer Nov 2024

First Record Of The Camphor Shot Borer, Cnestus Mutilatus (Blandford) (Coleoptera: Curculionidae: Scolytinae), In Massachusetts, Lawrence E. Barringer

Insecta Mundi

Cnestus mutilatus (Blandford) (Coleoptera: Curculionidae: Scolytinae) is reported from Massachusetts, United States for the first time. Brief trapping information is provided.


Thermotherapy Has Sexually Dimorphic Responses In App/Ps1 Mice., Samuel A Mcfadden, Mackenzie R Peck, Lindsey N Sime, Makayla F Cox, Erol D Ikiz, Caleigh A Findley, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup Nov 2024

Thermotherapy Has Sexually Dimorphic Responses In App/Ps1 Mice., Samuel A Mcfadden, Mackenzie R Peck, Lindsey N Sime, Makayla F Cox, Erol D Ikiz, Caleigh A Findley, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup

Articles

A thermoregulatory decline occurs with age due to changes in muscle mass, vasoconstriction, and metabolism that lowers core body temperature (Tc). Although lower Tc is a biomarker of successful aging, we have previously shown this worsens cognitive performance in the APP/PS1 mouse model of Alzheimer's disease (AD). We hypothesized that elevating Tc with thermotherapy would improve metabolism and cognition in APP/PS1 mice. From 6-12 months of age, male and female APP/PS1 and C57BL/6 mice were chronically housed at 23 or 30°C. At 12 months of age, mice were assayed for insulin sensitivity, glucose tolerance, and spatial cognition. Plasma, hippocampal, and …


Cryo-Em Structure Of A Photosystem I Variant Containing An Unusual Plastoquinone Derivative In Its Electron Transfer Chain, Christopher J. Gisriel, Vasily Kurashov, David F. Iwig, Brandon P. Russell, David J. Vinyard, Gary W. Brudvig, John H. Golbeck, K. V. Lakshmi Nov 2024

Cryo-Em Structure Of A Photosystem I Variant Containing An Unusual Plastoquinone Derivative In Its Electron Transfer Chain, Christopher J. Gisriel, Vasily Kurashov, David F. Iwig, Brandon P. Russell, David J. Vinyard, Gary W. Brudvig, John H. Golbeck, K. V. Lakshmi

Faculty Publications

Photosystem I (PS I) is a light-driven oxidoreductase responsible for converting photons into chemical bond energy. Its application for renewable energy was revolutionized by the creation of the MenB deletion (ΔmenB) variant in the cyanobacterium Synechocystis sp. PCC 6803, in which phylloquinone is replaced by plastoquinone-9 with a low binding affinity. This permits its exchange with exogenous quinones covalently coupled to dihydrogen catalysts that bind with high affinity, thereby converting PS I into a stable solar fuel catalyst. Here, we reveal the 2.03-Å-resolution cryo-EM structure of a recent MenB variant of PS I. The quinones and their binding environment are …


Early Detection Of Risk Factor For Suicidal Ideation Among Senior High School Students In Jakarta: Updated Measurement, Nova R. Yusuf, Sabarinah Prasetyo, Byron J. Good Nov 2024

Early Detection Of Risk Factor For Suicidal Ideation Among Senior High School Students In Jakarta: Updated Measurement, Nova R. Yusuf, Sabarinah Prasetyo, Byron J. Good

Kesmas

The key strategy to address suicide in adolescents is school-based suicidal prevention by adapting a screening instrument to the local culture and policymakers’ perception of suicide. This study aimed to develop an instrument for the early detection of risk for suicidal ideation and identify influential risk factors for suicidal ideation among high school students in Jakarta, Indonesia. This study was conducted in 2018 with a mixed-method design (quantitative and qualitative approaches). It was found that 5% of students had suicidal ideation in July–November 2018, and 13.8% had a high-risk factor for suicidal ideation. The instrument developed in this study consisted …


Assessment Of Free Drinking Water Facilities And Its Potential Health Risks: A Study In The University X, Indah Actry Zane Lumbantobing, Bambang Wispriyono, Fitri Kurniasari, Sifa Fauzia, Muhammad Nur Ihsan Ayyasy, Alissa Siti Haura, Ghina Labibah, Muhammad Abiyyu Akmal, Kirana Mahadewi Heryadi, Firda Alfianti, Nuranida Fauziyah Nov 2024

Assessment Of Free Drinking Water Facilities And Its Potential Health Risks: A Study In The University X, Indah Actry Zane Lumbantobing, Bambang Wispriyono, Fitri Kurniasari, Sifa Fauzia, Muhammad Nur Ihsan Ayyasy, Alissa Siti Haura, Ghina Labibah, Muhammad Abiyyu Akmal, Kirana Mahadewi Heryadi, Firda Alfianti, Nuranida Fauziyah

Kesmas

University X offers free drinking water facilities. However, it has a significant problem in accessing safe drinking water. This study aimed to examine the microbial and chemical parameters of the free drinking water facilities at University X. The microbial quality was assessed by evaluating the total coliform bacteria, and the chemical parameter assessment, substances such as nitrate, iron, manganese, hexavalent chromium, and fluoride were analyzed across 12 water samples from various locations within the university. Among these, only total coliform and fluoride levels exceeded the guidelines of the World Health Organization (WHO) and the Indonesian Ministry of Health. An Environmental …


Social Determinants Of Neonatal Health Outcomes In Indonesia: A Multilevel Regression Analysis, Rooswanti Soeharno, Amal Chalik Sjaaf Nov 2024

Social Determinants Of Neonatal Health Outcomes In Indonesia: A Multilevel Regression Analysis, Rooswanti Soeharno, Amal Chalik Sjaaf

Kesmas

Indonesia’s neonatal mortality rate remains alarmingly high. This study addressed the determinants of neonatal outcomes in Indonesia, including the effects of a decentralized health system, socioeconomic disparities, and geographic variations. The analysis used 2018 national survey data across 34 provinces, 513 cities/districts, and 300,000 households, with a sample of 73,864 women aged 10-54 years who have given birth in the preceding five years. The multilevel regression was used to assess the impact of social determinants and systemic inequalities on neonatal health. Key findings revealed a neonatal mortality rate that, despite being preventable in many cases, remained high with significant disparities. …


Human Capital Assessment In Indigenous Regions To Enable Sustainable Futures, Victoria N. Sharakhmatova, Elena G. Mikhailova Nov 2024

Human Capital Assessment In Indigenous Regions To Enable Sustainable Futures, Victoria N. Sharakhmatova, Elena G. Mikhailova

Faculty Publications

This study is dedicated to the economic valuation of human capital (HC) in the regions where the Indigenous peoples of Kamchatka reside. The entire Kamchatksky Krai is considered an Indigenous people’s ancestral territory. However, in this study, only municipalities whose population is more than one-third Indigenous were chosen for the assessment. This includes six municipal districts and one urban district (Aleytsky, Bystrinsky, Karaginsky, Olyutorsky, Penzhinsky, and Tigilsky municipal districts and Palana urban district). The study employs statistical analysis and integrated, situational approaches: the investment approach was deemed the most appropriate tool for the economic assessment of HC in Indigenous territories. …


An Assessment Of The Impact Of Fentanyl On Post-Mortem Interval From A Decomposition And Biochemical Perspective, Kaylene Mcdonald Nov 2024

An Assessment Of The Impact Of Fentanyl On Post-Mortem Interval From A Decomposition And Biochemical Perspective, Kaylene Mcdonald

Senior Honors Theses

In the realm of body decomposition, bodies undergo a plethora of different metabolic and chemical changes. The human body follows a very consistent pattern and predictable time frame, with the exclusion of extenuating circumstances. The presence of fentanyl at the time of death provides the possibility of changes in decomposition rates, potentially skewing the time of death estimations. This research analyzes the varying decompositional stages of a body and their subsequent close relations with activity in the environment around it, specifically investigating the impacts of fentanyl on those surroundings and postmortem interval estimation determinations. This research found evidence that fentanyl …


Multi-Temporal Analysis Of Urbanization-Driven Slope And Ecological Impact Using Machine-Learning And Remote Sensing Techniques, Zhang Hao, Muhammad Haseeb, Zheng Xiangtian, Zainab Tahir, Syed Amer Mahmood, Aqil Tariq, Rana Waqar Aslam, M. Abdullah-Al-Wadud, Hesham El-Askary Nov 2024

Multi-Temporal Analysis Of Urbanization-Driven Slope And Ecological Impact Using Machine-Learning And Remote Sensing Techniques, Zhang Hao, Muhammad Haseeb, Zheng Xiangtian, Zainab Tahir, Syed Amer Mahmood, Aqil Tariq, Rana Waqar Aslam, M. Abdullah-Al-Wadud, Hesham El-Askary

Mathematics, Physics, and Computer Science Faculty Articles and Research

Rapid urbanization in Lahore, Pakistan, has led to significant ecological and thermal challenges, particularly the intensification of Urban Heat Island (UHI) effects and increased thermal stress as measured by the Urban Thermal Field Variance Index (UTFVI). This study employs a multi-temporal evaluation of Landsat satellite imagery and GIS-based analysis to investigate the Spatio-temporal trends in land-use and land-cover (LULC) changes from 1994 to 2024. We detected substantial changes in urban growth, vegetation cover, and barren areas using supervised classification (Random Forest) methods and remote sensing indices such as NDVI (Normalized Difference Vegetation Index), NDMI (Normalized Difference Moisture Index), NDBI (Normalized …


Akt Kinases As Therapeutic Targets, Dalal Hassan, Craig Menges, Joseph Testa, Alfonso Bellacosa Nov 2024

Akt Kinases As Therapeutic Targets, Dalal Hassan, Craig Menges, Joseph Testa, Alfonso Bellacosa

Student Papers, Posters & Projects

AKT, or protein kinase B, is a central node of the PI3K signaling pathway that is pivotal for a range of normal cellular physiologies that also underlie several pathological conditions, including inflammatory and autoimmune diseases, overgrowth syndromes, and neoplastic transformation. These pathologies, notably cancer, arise if either the activity of AKT or its positive or negative upstream or downstream regulators or effectors goes unchecked, superimposed on by its intersection with a slew of other pathways. Targeting the PI3K/AKT pathway is, therefore, a prudent countermeasure. AKT inhibitors have been tested in many clinical trials, primarily in combination with other drugs. While …


Legacy Effects Of Plant Community Structure Are Manifested In Microbial Biofilm Development With Consequences For Ecosystem Co Emissions, Kevin H. Wyatt, Jillian Cieslik, Catherine M. Dieleman, Evan Kane, Allison R. Rober, Barrett Sullivan, Merritt R. Turetsky Nov 2024

Legacy Effects Of Plant Community Structure Are Manifested In Microbial Biofilm Development With Consequences For Ecosystem Co Emissions, Kevin H. Wyatt, Jillian Cieslik, Catherine M. Dieleman, Evan Kane, Allison R. Rober, Barrett Sullivan, Merritt R. Turetsky

Michigan Tech Publications

To better understand linkages between hydrology and ecosystem carbon flux in northern aquatic ecosystems, we evaluated the relationship between plant communities, biofilm development, and carbon dioxide (CO) exchange following long-term changes in hydrology in an Alaskan fen. We quantified seasonal variation in biofilm composition and CO exchange in response to lowered and raised water table position (relative to a control) during years with varying levels of background dissolved organic carbon (DOC). We then used nutrient-diffusing substrates (NDS) to evaluate cause-effect relationships between changes in plant subsidies (i.e., leachates) and biofilm composition among water table treatments. We found that background DOC …


Accumbal Plasticity And Associated Behavioral Adaptations In The Spared Nerve Injury Model Of Chronic Neuropathic Pain, Yu-Hsuan Chang Nov 2024

Accumbal Plasticity And Associated Behavioral Adaptations In The Spared Nerve Injury Model Of Chronic Neuropathic Pain, Yu-Hsuan Chang

Arts & Sciences Graduate Student Theses and Dissertations

Chronic pain is a debilitating neurological disorder that affects hundreds of millions of individuals worldwide. It is associated with cognitive symptoms such as cognitive inflexibility, which is defined as the inability to adaptively update behavior in response to changing environmental conditions. To date, there are no effective treatments for these symptoms, even though they substantially contribute to the decreased quality of life of chronic pain patients and are associated with reduced efficacy of pain management strategies. Therefore, understanding the neural circuit adaptations that drive cognitive symptoms of chronic pain, like cognitive inflexibility, is essential for improving existing treatments for this …


Id1 And Id3 Functions In The Modulation Of The Tumour Immune Microenvironment In Adult Patients With B-Cell Acute Lymphoblastic Leukaemia, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita Nov 2024

Id1 And Id3 Functions In The Modulation Of The Tumour Immune Microenvironment In Adult Patients With B-Cell Acute Lymphoblastic Leukaemia, Nathaly Poveda-Garavito, Carlos A. Orozco Castaño, Yulieth Torres-Llanos, Nataly Cruz-Rodriguez, Rafael Parra-Medina, Sandra Quijano, Jovanny Zabaleta, Alba Lucia Combita

School of Medicine Faculty Publications

Introduction: B-cell acute lymphoblastic leukemia (B-ALL) in adults often presents a poor prognosis. ID1 and ID3 genes have been identified as predictors of poor response in Colombian adult B-ALL patients, contributing to cancer development. In various cancer models, these genes have been associated with immune regulatory populations within the tumor immune microenvironment (TIME). B-ALL progression alters immune cell composition and the bone marrow (BM) microenvironment, impacting disease progression and therapy response. This study investigates the relationship between ID1 and ID3 expression, TIME dynamics, and immune evasion mechanisms in adult B-ALL patients. Methods: This exploratory study analysed BM samples from 10 …


An Evaluation Of A Multidisciplinary Care Planning Tool For People With Intellectual Disabilities And Behaviours Of Concern, Rohit Shankar Nov 2024

An Evaluation Of A Multidisciplinary Care Planning Tool For People With Intellectual Disabilities And Behaviours Of Concern, Rohit Shankar

Peninsula Medical School

No abstract provided.


A Tetramer Of Bcl11a Is Required For Stable Protein Production And Fetal Hemoglobin Silencing, Ge Zheng, Maolu Yin, Stuti Mehta, I-Te Chu, Stacy Wang, Alia Alshaye, Kirstin Drainville, Altantsetseg Buyanbat, Frédérique Bienfait, Karin Tenglin, Qian Zhu, Stuart H Orkin Nov 2024

A Tetramer Of Bcl11a Is Required For Stable Protein Production And Fetal Hemoglobin Silencing, Ge Zheng, Maolu Yin, Stuti Mehta, I-Te Chu, Stacy Wang, Alia Alshaye, Kirstin Drainville, Altantsetseg Buyanbat, Frédérique Bienfait, Karin Tenglin, Qian Zhu, Stuart H Orkin

Faculty, Staff and Students Publications

Down-regulation of BCL11A protein reverses the fetal (HbF, α2γ2) to adult (HbA, α2β2) hemoglobin switch and is exploited in gene-based therapy for hemoglobin disorders. Due to reliance on ex vivo cell manipulation and marrow transplant, such therapies cannot lessen disease burden. To develop novel small molecule approaches, we interrogated the state of BCL11A protein in erythroid cells. We report that tetramer formation mediated by a single zinc-finger (ZnF0) is required for production of steady-state protein. Beyond its role in protein stability, the tetramer state is necessary for γ-globin gene repression, as an engineered monomer fails to engage a critical corepressor …