Digital Commons Network^™

Assessing Impact Risk To Tropical Marine Ecosystems From Human Activities With A Southeast Asian Example, Fiona Culhane, Melanie C. Austen, Matthew Ashley, Jonson Javier, Sui Hyang Kuit, Nguyen Phuc Hung, Hau Duc Tran, Radisti A. Praptiwi, Sainal Sainal, Eva Justine, Prawesti Wulandari, Stefanie Broszeit, Jean Beth Jontila, Sofia Johari, Lota Creencia, Amy Yee Hui Then, Lea Janine Gajardo, Carya Maharja, Hong Ching Goh, Wan Mohd Syazwan, Yang Amri Affendi, Lê Ngọc Thảo, Jito Sugardjito, Tom Mullier, Olivia Langmead

School of Biological and Marine Sciences

Society relies on intact marine ecosystems for ecosystem services such as nutrition, livelihoods, health and well-being. Yet, to obtain these benefits, we carry out activities, introducing pressures to ecosystems, damaging and degrading habitats and reducing their capacity to optimally provide ecosystem services. Biodiversity and ecosystem services are consequently being lost globally but impact chains from these activities are poorly understood, especially in tropical marine ecosystems. We identified for the first time impact chains linking activities with pressures they introduce in five tropical coastal and marine habitats, specifically through application in four Southeast Asian case study sites. Using expert elicitation based …

A Sentinel Watching Over Inter-Tidal Seagrass Phenology Across Western Europe And North Africa, Bede Ffinian Rowe Davies, Simon Oiry, Philippe Rosa, Maria Laura Zoffoli, Ana I. Sousa, Oliver R. Thomas, Dan A. Smale, Melanie C. Austen, Lauren Biermann, Martin J. Attrill, Alejandro Roman, Gabriel Navarro, Anne Laure Barillé, Nicolas Harin, Daniel Clewley, Victor Martinez-Vicente, Pierre Gernez, Laurent Barillé

School of Biological and Marine Sciences

Seagrasses are marine flowering plants that form extensive meadows from the inter-tidal zone up to ~50 m depth. As biological and ecological Essential Biodiversity Variables, seagrass cover and composition provide a wide range of ecosystem services. Inter-tidal seagrass meadows provide services to many ecosystems, so monitoring their occurrence, extent, condition and diversity can be used to indicate the biodiversity and health of local ecosystems. Current global estimates of seagrass extent and recent reviews either do not mention inter-tidal seagrasses and their seasonal variation, or combine them with sub-tidal seagrasses. Here, using high-spatial and high-temporal resolution satellite data (Sentinel-2), we demonstrate …

What Is The Evidence? Updates In The Use Of Antenatal Corticosteroids For Patients At Risk Of Preterm Birth, Moti Gulersen, Cynthia Gyamfi-Bannerman

Department of Obstetrics and Gynecology Faculty Papers

Antenatal corticosteroids have long been considered one of the most important antenatal therapies available for pregnant patients at risk of preterm birth based on the associated reduction of neonatal morbidity and mortality following their administration. However, despite decades of research since their incorporation into routine clinical practice, a number of key questions related to antenatal corticosteroid use remain. These include evaluating the impact of antenatal corticosteroids at gestational ages outside of the previously recommended window of 24 0/7–33 6/7 weeks of gestation, determining factors associated with optimal steroid timing in order to reduce unnecessary exposure, alterations in its dosing regimen, …

Dysfunctional Alpha Modulation As A Mechanism Of Working Memory Impairment In Serious Mental Illness, Molly A Erickson, Megan A Boudewyn, Kurt Winsler, Charlotte Li, Deanna M Barch, Cameron S Carter, Michael J Frank, James M Gold, Angus W Macdonald 3rd, John D Ragland, Steven M Silverstein, Andrew Yonelinas, Steven J Luck

2020-Current year OA Pubs

BACKGROUND: People with psychosis and mood disorders experience disruptions in working memory; however, the underlying mechanism remains unknown. We focused on 2 potential mechanisms: poor attentional engagement should be associated with elevated levels of prestimulus alpha-band activity within the electroencephalogram (EEG), whereas impaired working memory encoding should be associated with reduced poststimulus alpha suppression.

METHODS: We collected EEG data from 68 people with schizophrenia, 43 people with bipolar disorder with a history of psychosis, 53 people with major depressive disorder, and 90 healthy comparison subjects while they completed a spatial working memory task. We quantified attention lapsing, memory precision, and …

The Effects Of Mosaicism On Biological And Clinical Markers Of Alzheimer's Disease In Adults With Down Syndrome, Laura Xicota, Rachel L Henson, Beau Ances, Et Al.

2020-Current year OA Pubs

BACKGROUND: Individuals with Down syndrome (DS) are at high risk of early-onset Alzheimer's disease (AD); yet, some 20 percent do not develop any signs of dementia until after 65 years or in their lifetime. Mosaicism could contribute to this phenotypic variation, where some disomic cells could lead to lower levels of gene products from chromosome 21.

METHODS: We examined longitudinal neuropsychological and biomarker data from two large studies of DS: the Alzheimer Biomarker Consortium-Down syndrome study (ABC-DS) (n = 357); and a legacy study (n = 468). We assessed mosaicism using karyotyping or GWAS data. Participants had data on plasma …

Quantifying Brain Development In The Healthy Brain And Child Development (Hbcd) Study: The Magnetic Resonance Imaging And Spectroscopy Protocol, Douglas C Dean 3rd, Chad M Sylvester, Michael P Harms, Christopher D Smyser, Et Al.

2020-Current year OA Pubs

The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition …

Emergent Microenvironments Of Nucleoli, Matthew R King, Kiersten M Ruff, Rohit V Pappu

2020-Current year OA Pubs

In higher eukaryotes, the nucleolus harbors at least three sub-phases that facilitate multiple functionalities including ribosome biogenesis. The three prominent coexisting sub-phases are the fibrillar center (FC), the dense fibrillar component (DFC), and the granular component (GC). Here, we review recent efforts in profiling sub-phase compositions that shed light on the types of physicochemical properties that emerge from compositional biases and territorial organization of specific types of macromolecules. We highlight roles played by molecular grammars which refers to protein sequence features including the substrate binding domains, the sequence features of intrinsically disordered regions, and the multivalence of these distinct types …

Analyzing Sars-Cov-2 Wastewater Surveillance Data For Public Health Impact In Southern Nevada, Casey A. Barber

UNLV Theses, Dissertations, Professional Papers, and Capstones

Background: Early in the COVID-19 pandemic, researchers determined that levels of severe acute respiratory coronavirus 2 (SARS-CoV-2) genetic material in wastewater could provide information about COVID-19 occurrence in communities. Wastewater-based epidemiology (WBE) efforts have subsequently expanded throughout the U.S. and internationally; the U.S. Centers for Disease Control and Prevention (CDC) initiated its National Wastewater Surveillance System (NWSS) in September of 2020 and continues its SARS-CoV-2 wastewater monitoring efforts following the end of the federal COVID-19 public health emergency in May 2023. The field of WBE has reached a critical juncture in determining the future of how SARS-CoV-2 wastewater surveillance data …

Understanding Failure Mechanisms For Two Colorectal Anastomosis Techniques, Youssef Sherif Sadek Fahmy

UNLV Theses, Dissertations, Professional Papers, and Capstones

Colorectal Surgery continues to be one of the most common gastrointestinal surgeries performed in the US. A common complication known as Anastomotic Leakage (AL) that threatens up to 30% of patients with this surgery. Many cases of AL can decrease the quality of life for patients or extensively extend hospital stays, and in many cases, lead to death. Researchers have studied this complication in clinical trials, yet few studied the mechanics of stapled anastomosis in controlled environments. The purpose of this research was to understand the mechanical interaction between the staples and the tissue, and to eventually apply it in …

From Resistance To Host Response: An Integrative Study Of C. Difficile Infections, Amber Consul

UNLV Theses, Dissertations, Professional Papers, and Capstones

Clostridioides difficile infection (CDI) is a major healthcare challenge, causing severe gastrointestinal illness and significant mortality. Understanding the mechanisms of antibiotic resistance, epidemiology, and immune response in CDI is critical for developing effective treatments and prevention strategies.

This dissertation encompasses three complementary studies. The first study investigates the genetic mechanisms underlying cephalosporin resistance in C. difficile strain 630 through differential gene expression analysis. The second study provides a descriptive epidemiological analysis of C. difficile ribotypes in a Las Vegas patient population, highlighting differences between healthcare-associated (HA-CDI) and community-associated (CA-CDI) cases. The third study integrates serum analyte profiling and transcriptomic analysis …

The Effects Of Casein Glycomacropeptide On General Health Status In Children With Pku: A Randomized Crossover Trial, Alex Pinto, Anne Daly, Camille Newby, Abigail Robotham, Simon Heales, Simon Eaton, Helen Aitkenhead, Kimberly Gilmour, Richard Jackson, Catherine Ashmore, Sharon Evans, Júlio Cesar Rocha, Fatma Ilgaz, Mary Hickson, Anita Macdonald

School of Health Professions

In PKU, it is suggested that casein glycomacropeptide based protein substitute (GMP) may have physiological advantage when satiety, oxidative stress, renal function and inflammation are considered. Its prebiotic properties may also help gastrointestinal (GI) tolerance. In children with PKU, a randomized/crossover trial comparing phenylalanine-free amino acids (AA) vs GMP as the single source of protein substitute for 12-weeks in each arm was conducted. There was a 4-week wash out period with AA in-between. At baseline and end of each intervention, blood and fecal samples were taken to monitor gut health, oxidative stress, renal function, inflammatory markers and plasma amino acids. …

Site Position, Tillage, And Soil Depth Effects On Soil Properties In A Furrow-Irrigated Rice Field On A Silt-Loam Soil, Hannah Nobles, Kristofor Brye, Diego Della Lunga

Crop, Soil and Environmental Sciences Undergraduate Honors Theses

The fundamental agronomic shift from conventional agricultural methods to conservation agriculture relies on understanding soil nutrient stratification with depth and under different tillage treatments. Assessment of nutrient stratification in the dynamic conditions of furrow-irrigated rice (Oryza sativa) systems in eastern Arkansas is absent. The objective of this study was to evaluate the effects of tillage [i.e., conventional tillage (CT) and no tillage (NT], site position (i.e., up-, mid-, and down-slope), soil depth interval (i.e., 0-10 and 10-20 cm), and their interaction on the difference (i.e., end of the season minus beginning of the season) in select soil chemical …

Low Toxicity Of Dissolved Silver From Silver-Coated Titanium Dental Implants To Human Primary Osteoblast Cells, Ranj Nadhim Salaie, Alexandros Besinis, Christopher Tredwin, Richard D Handy

School of Engineering, Computing and Mathematics

The controlled release of silver as a biocide from Ag-coated medical implants is desirable. However, the biocompatibility of Ag leachates is poorly understood. This study investigated the toxicity of silver released from the silver plated titanium implants to human primary osteoblast cells; and the effect of cell culture medium on the silver speciation and bioavailability.

METHODS: Ti6Al4V discs were coated with Ag nanoparticles (NPs), silver plus hydroxyapatite (HA) nanoparticles (Ag+nHA), or Ag NPs plus microparticles (Ag+mHA). Primary human osteoblast cells were exposed to the leachates from the various discs for up to 7 days.

RESULTS: the total Ag concentrations released …

Higher Abundance Of Disturbance-Favoured Trees And Shrubs In European Temperate Woodlands Prior To The Late-Quaternary Extinction Of Megafauna, Elena A. Pearce, Florence Mazier, Ralph Fyfe, Charles W. Davison, Signe Normand, Maria Antonia Serge, Paolo Scussolini, Jens Christian Svenning

School of Geography, Earth and Environmental Sciences

Large herbivorous mammals strongly influence vegetation structure by creating and maintaining open areas and causing disturbance within closed woody habitats. The herbivores alive today in Europe are only a small remnant of the large species that existed in high diversity and abundance before modern humans. The extinction of so many large herbivores during the last 50,000 years, and the loss of megaherbivores (body weight ≥1000 kg) from most of the continent before the Pleistocene–Holocene transition, is likely to have had cascading effects on vegetation structure and composition. To evaluate these effects within the European temperate forest biome, we examine the …

Impact Of The 2020 Covid-19 Lockdown On The Concentration Of Non-Methane Volatile Organic Compounds In A Uk Urban Atmosphere, Emmanuel Bernard, Rebecca L. Cordell, Robert S. Blake, Michael J. Wilde, Paul S. Monks

School of Geography, Earth and Environmental Sciences

The changes in air quality brought about by the COVID-19 lockdowns can provide valuable insight into how longer-term reductions in emissions might affect atmospheric composition. In urban Leicester UK, the 2020 COVID “lockdown” brought about several notable changes in atmospheric composition, including a considerable decrease (20–60%) in concentrations of non-methane volatile organic compounds (NMVOCs). Given their varied emission sources and lifetimes, NMVOC data can give valuable insights into how behavioural change impact atmospheric composition. The total concentration of 48 NMVOCs at roadside (RS) sites decreased from a pre-lockdown (sampled 16th-24th March 2020) concentration of 181.3 ± 41.4 μg/m³ to …

Environmental Transport And Sorting Of Glass Retroreflective Microbeads And Their Potential As Proxies For Road Marking Paints, Andrew Turner, Adam Bridgwater, Emily Marshall

School of Geography, Earth and Environmental Sciences

Road marking paints are a potentially important contributor to the global microplastic pool but very little reliable information is available on their erosion or environmental distributions. As potential carriers of or proxies for road paints, we determine the concentrations and sorting of retroreflective glass microbeads in marking materials and in fractionated (< 5 mm) local dusts, soils and sediments. As an aid to our investigation, we also determine the concentrations of metals of geochemical significance or components of road paint pigments in markings and geosolids. Concentrations of beads up to 92,800 kg⁻¹ were observed in street dusts, with a median diameter (350 μm) greater than that in road marking samples (270 μm). Few beads were found in adjacent (< 5 m) or more remote soils (six beads in ten 50-g samples) and none were detected in replicates of a sample of roof dust, suggesting that aeolian transport is limited. Concentrations up to 3700 kg⁻¹ were found in estuarine sediments close to bridges or stormwater runoff effluents, and with increasing sediment depth concentrations and …

Costly Signaling Theory, Hui Ying Ivy Koh, Norman P. Li

Research Collection School of Social Sciences

Costly signaling theory is the idea that the high costs incurred by an individual to convey information about underlying qualities keeps this signal reliable, as only individuals who truly possess the quality signaled can afford to send the signal.

High-Country Currents: Wonder, Never Cease, Lucille Stott

Appalachia

No abstract provided.

Appalachia Summer/Fall 2004: Complete Issue

Appalachia

No abstract provided.

Accidents

Appalachia

No abstract provided.

Tundra Frogs: Previously Unrecorded Amphibian Life In The Northeast's Alpine Zone, Michael Jones

Appalachia

No abstract provided.

High-Country Currents: Leaving The Journal But Not The Pack, Lucille Stott

Appalachia

No abstract provided.

Appalachia Winter/Spring 2006: Complete Issue

Appalachia

No abstract provided.

Evaluating The Effect Of Chemotherapy Notch1 Gene Expression In Patients With Prostate Cancer, Mustafa S. Khudhur, Ali Adil Majeed

Al-Ameed Journal for Medical Research and Health Sciences

This study was conducted on 50 cases of prostate cancer patients and 20 apparently healthy. The study analyzed the distribution of prostate cancer (PC) patients across various categories. Significant differences were observed in group grades, Gleason scores, cell grades, stages, and dose names. The mean age of the patient cohort was 67.84 years with a median diagnosis time of 7 years. Laboratory assays including measurements of red blood cells count, platelet count, white blood cells count, and prostate specific antigene levels. The mean total chemotherapy dose received by patients was 1708.28. Significant differences were found in the distribution of group …

Learning As A Child In Gopnik's The Philosophical Baby, Christopher Joseph An

Budhi: A Journal of Ideas and Culture

Learning as a Child in Gopnik's The Philosophical Baby

Gareth Matthews And The Philosophy Of Childhood, Marella Ada V. Mancenido-BolañOs

Budhi: A Journal of Ideas and Culture

Gareth Matthews and the Philosophy of Childhood

The Androgynous Baglan: Interruption, Withdrawal, And Reclaiming, Aurelio S. Agcaoili

Budhi: A Journal of Ideas and Culture

The pursuit of decolonization is a first act in the manifold acts of real, because substantive, liberation of a colonized country like the Philippines. The reason is clear: every colonizer not only colonizes a country but invades and occupies the mind of the people of that country, puts a claim to their bodies, and replaces their language and cultural practices with his own to complete his violent act of “discovering” the Other. Even with independence granted to a colonized people, the intellectual residues in a colonized consciousness that has coopted with the colonizer if only to survive continue to haunt, …

America: The Janus Nation, Peter Murphy

Budhi: A Journal of Ideas and Culture

America is a paradoxical society. That is one of its strengths. One of its weaknesses is its periodic inability to understand its own paradoxical nature. It is a Janus nation, one in which (in principle) incompatible things exist in a simultaneous state. When this paradoxical fusion works, it has great benefits. When it fails to work, American society loses its inner equilibrium. Pugnacious antagonisms arise in its place. The tension within the United States between the drive toward a union of opposites (most famously embodied in its Constitution) and the periodic centrifugal spinning out of American society into a state …

How To Love In Easy Steps: Heteronormativity, Queer Love, And Foucault's Counter-Conduct, Hannah Jane S. Carpiso, Ninotchka Mumtaj B. Albano

Budhi: A Journal of Ideas and Culture

Love is one of the most pervasive human experiences, yet its definition remains elusive to this day. Attempts to describe love have led to the institutionalization and privileging of heterosexual identities, relationships, and ways of loving. Michael Warner refers to this phenomenon as “heteronormativity,” which rigidifies subjectivities and relationalities into fixed, heterosexist structures. However, queer love unfolds in ways different from this relational structure. It invents and re-invents love, relationalities, and subjectivities by moving beyond the dichotomies of heteronormativity. The inventive characteristic of queer love is found in what is known as the “gay mode of life,” an instance of …

Book Review: The Mindset Of A Dyslexic Entrepreneur: The Scott Holman Story By Don Steele, Russell Magnaghi

Upper Country: A Journal of the Lake Superior Region

No abstract provided.