Digital Commons Network^™

Cyclical Musicians: Collegiate Music Students’ Experiences Of Instrumental Musicking Processes Across The Menstrual Cycle, Anne Marques Catarin

Theses and Dissertations

Instrumental music researchers tend to focus on non-sex-specific health topics, such as posture (e.g., Garnett et al., 2022; Rousseau et al., 2023), musculoskeletal health (e.g., Mizrahi, 2020; Pratt et al., 2020), or neurological movement disorders (e.g., Altenmüller & Jabusch, 2010; Frucht, 2009). Despite the considerable extent of topics covered in musician health, the role of menstrual health in instrumentalists is currently underdeveloped. Using a case study design (Stake, 1995; Yin, 2014), I explored the unspoken experiences of collegiate instrumental music majors who menstruate, in an investigation to better understand the role of menstrual cycles in their musicking. For four months, …

Development Of Fluorescent-Based Nanoparticles For Bioimaging, Gene Regulation Expression, And Photo-Induced Synergistic Cancer Therapy, Di Sun

Theses and Dissertations

Fluorescent-based nanoparticles have been applied to a broad range of biological applications, as discussed in this dissertation, including bioimaging, gene regulation expression, and photo-induced synergistic cancer therapy. Prior to applications, this dissertation first focused on the development and characterization of several fluorescent-based nanoparticles using different methods. These include 1) Streamlined synthesis of dual-emissive fluorescent-based silicon quantum dots (SiQDs). The SiQDs were generated as a promising, non-toxic labeling tool for bioimaging of a variety of cell types. both in visible and near-infrared (NIR) ranges. 2) Polymer-based nanoparticles - Polymer dots (Pdots) with a strong NIR fluorescence. The Pdots were functionalized as …

“How Can I Teach When I Was Not Taught How?”: Teacher Education For Mother Tongue Instruction For Stem In Southwest Nigeria, Motunrayo Adeosun

Theses and Dissertations

In this qualitative study, the experiences, training, and challenges of teachers in primary schools in a community in southwest Nigeria were explored. The purpose of this study was to identify the experiences of teachers about their training for mother tongue instruction and how they teach pupils with the mother tongue or local language of the community, the challenges faced by teachers in teaching with the mother tongue, and the strategies used by teachers to overcome the challenges. This study found that teachers received no training and there is no curriculum for the training of teachers to teach in the mother …

Parp1 Modulates Gata3-Mediated Gene Regulation In Breast Cancer, Mikhala Cooper

Theses and Dissertations

In eukaryotic cells, chromatin acts as a physical barrier for many transcription factors, preventing them from efficiently binding to their recognition sequences within the nucleosome. Pioneer factors are a class of transcription factors that bind to nucleosomes and activate silent chromatin. Pioneer factors are frequently involved in various immune cell pathways, tissue development, and homeostasis, thereby underscoring their important roles in development and disease. Previous research found that pioneer factors have at least three fundamental properties: 1) they can interact with their cognate recognition sequences before transcription activation, 2) they can increase local chromatin accessibility, and 3) they have integral …

Zero-G Exercise Equipment, Charisse Biglete, Jake Brajevich, James Monroe, Ethan Siahpush

Mechanical Engineering

In a micro-gravitational environment, the body undergoes less loading than that found on Earth. This leads to muscular atrophy, Osteoporosis, decreases in protein synthesis, and various other undesirable outcomes. To prevent this, astronauts undergo a strict exercise regime to maintain their health. The current exercise equipment available for spacecraft is large, heavy, complicated to use, costly, and unsafe. There is a definite need for the re-engineering of the exercise equipment to be used by astronauts while in microgravity environments to rectify these issues.

Eigenbin Compression For Reducing Photon-Counting Ct Data Size, Taly Gilat Schmidt, Zhye Yin, Jingwu Yao, Jiahua Fan

Biomedical Engineering Faculty Research and Publications

Background

Photon-counting CT (PCCT) systems acquire multiple spectral measurements at high spatial resolution, providing numerous image quality benefits while also increasing the amount of data that must be transferred through the gantry slip ring.

Purpose

This study proposes a lossy method to compress photon-counting CT data using eigenvector analysis, with the goal of providing image quality sufficient for applications that require a rapid initial reconstruction, such as to confirm anatomical coverage, scan quality, and to support automated advanced applications. The eigenbin compression method was experimentally evaluated on a clinical silicon PCCT prototype system.

Methods

The proposed eigenbin method performs principal …

Predator-Prey Interactions And Space Use Strategies For Two Mesocarnivores, Abigail Weber

Theses

Mesocarnivores, including bobcats (Lynx rufus) and coyotes (Canis latrans), serve an important ecological role, functioning as the top predators throughout much of the eastern United States due to the extirpation of larger-bodied carnivores. Mesocarnivores are often described as generalists due to their flexibility in forage and habitat preferences and their ability to persist in human-dominated landscapes. However, this characterization overlooks the fact that many individuals within these populations act as specialists, with movement, space use, and predation strategies varying between individuals and across environmental contexts. Quantifying variability in mesocarnivore space use and movement from multiple perspectives can provide a better …

Investigating The Effect Of Metal Site Of The Leaf And Branch Compost Cutinase Through Molecular Dynamics Simulations, Ryan James Molitor

Theses

The petroleum-based polyethylene terephthalate (PET) is a versatile and synthetic polymer that plays a pivotal role in the economy, including packaging, textiles, 3D printers, and even medical-related applications. There is a need for plastic waste management. Biological up-cycling of PET is a promising method for a clean and sustainable future. In 2012, a group of researchers, Tournier et. al., performed experiments and molecular dynamics simulations on the Leaf-branch Compost Cutinase, LCC (PDB Code: 4EB0), which outperformed the PET hydrolysis activity compared to three other PET hydrolyzing enzymes. The LCC and PET depolymerization rate of wildtype LCC was reported to be …

Insights From Father-Toddler Communication Via Tiktok, Joy Lee Hernandez, Abha Gupta

Teaching & Learning Faculty Publications

This qualitative study investigates the characteristics of interactions between fathers and toddlers, as well as their influence on language development. By utilizing video clips from the social media platform TikTok, this research observes and analyses fathers' responses and interactions with their toddlers. The findings indicate that fathers play a crucial role in supporting language development by engaging in conversations, expanding vocabulary, and providing emotional support. The study underscores the significance of fathers' involvement in nurturing language skills during early childhood. However, further longitudinal research is necessary to establish a definitive link between fathers' language input and toddlers' language development. Overall, …

A Multiscale Approach To Understanding The Shared Blue-Orange Flower Color Polymorphism In Two Lysimachia Species, Mercedes Sánchez-Cabrera, Eduardo Narbona, Montserrat Arista, Pedro L. Ortiz, Francisco J. Jiménez-López, Amelia Fuller, Benjamin Carter, Justen B. Whittall

Faculty Research, Scholarly, and Creative Activity

Background: Polymorphisms are common in nature, but they are rarely shared among closely related species. Polymorphisms could originate through convergence, ancestral polymorphism, or introgression. Although shared neutral genomic variation across species is commonplace, few examples of shared functional traits exist. The blue-orange petal color polymorphisms in two closely related species, Lysimachia monelli and L. arvensis were investigated with UV-vis reflectance spectra, flavonoid biochemistry, and transcriptome comparisons followed by climate niche analysis. Results: Similar color morphs between species have nearly identical reflectance spectra, flavonoid biochemistry, and ABP gene expression patterns. Transcriptome comparisons reveal two orange-specific genes directly involved in both blue-orange …

Gc-Ms Analysis And Evaluation Of Antioxidant, Anticancer, Cytotoxicity, And Hypoglycemic Properties Of The Libyan Moringa Oleifera Leaf Extract On Alloxan-Induced Diabetes In Mice, Osama Abdel-Hafeez Mohammed Al-Bedak, Ahlam Rashed, Seham T.M. Oskandali, Nouri Kushlaf, Amal Eishebani, Samira A. Alacrouk, Fadia T.M. Oshkandale, Manal Eisheli, Zahur R. Almesai, Ameerah Shaeroun, Steven L. Stephenson, Fuad Ameen

Biological Sciences Faculty Publications and Presentations

Libyan Moringa oleifera leaves were extracted using methanol, and the bioactive components' antibacterial, antioxidant, anti-inflammatory, and anticancer characteristics were assessed using gas chromatography mass spectrometry analysis (GC-MS). Moringa oleifera exhibited antioxidant activity, with an IC50 of 11.53 µg/mL. Wi38 cell line's viability decreased with increasing M. oleifera extract concentration, while its cytotoxicity increased with an IC50 of 393.41±7.77 μg/mL. Alloxan-induced diabetes model in Swiss albino mice was implemented. Three different doses (100, 200, or 300 mg/kg of mice body weight) of M. oleifera’s extract were evaluated for their effects on blood sugar concentration and the histology of the pancreatic islets. …

Piloting A Novel Computational Framework For Identifying Prosthesis-Specific Contributions To Gait Deviations, Jacques Ezechiel N'Guessan, Muhammad Hassaan Ahmed, Matthew Leineweber, Sachin Goyal

Faculty Research, Scholarly, and Creative Activity

This paper introduces a novel computational framework for evaluating above-knee prostheses, addressing a major challenge in gait deviation studies: distinguishing between prosthesis-specific and patient-specific contributions to gait deviations. This innovative approach utilizes three separate computational models to quantify the changes in gait dynamics necessary to achieve a set of ideal gait kinematics across different prosthesis designs. The pilot study presented here employs a simple two-dimensional swing-phase model to conceptually demonstrate how the outcomes of this three-model framework can assess the extent to which prosthesis design impacts a user's ability to replicate the dynamics of able-bodied gait. Furthermore, this framework offers …

Genetic Diversity And Population Structure Of Tomato (Solanum Lycopersicum) From The Usda-Grin Germplasm Collection, Ibtisam Alatawi, Haizheng Xiong, Hanan Alkabkabi, Kenani Chiwina, Qing Luo, Kai-Shu Ling, Yuejun Qu, Renjie Du, Ainong Shi

Horticulture Faculty Publications and Presentations

The genetic diversity and population structure of tomato (Solanum lycopersicum) were investigated to support breeding strategies and germplasm conservation. A total of 276 accessions from the USDA-GRIN collection were analyzed using single-nucleotide polymorphisms (SNPs) generated through genotyping by sequencing (GBS). After stringent filtering, 5162 high-quality polymorphic SNPs were retained for analysis. Population structure analysis revealed three distinct genetic groups (Q1, Q2, and Q3) among the accessions. Accessions from the USA, Asia, and Central and South America were assigned to all three groups, while accessions from Europe and Oceania were predominantly clustered within Q2. Genetic diversity indices, including major …

Investigating The Role That Calcium And The Membrane Play In 8r-Lipoxygenase Catalysis, Kaelie Bernard

Honors Capstones

No abstract provided.

Just Fix The Damn Payment System!, Frances H. Miller

Faculty Scholarship

This piece takes as a given that we are stuck with our fragmented, inefficient, multi-payor health care system for at least the short run. It then analyzes the deficiencies of three payment mechanisms whereby regulators (including Congress) have invited private sector providers to help ameliorate perceived problems. The first concerns an inadequate supply of nursing home beds in the early ‘70s, the next focuses on Medicare Advantage as a supposedly superior cost containment alternative to traditional Medicare, and the final one involves the ‘devil’s bargain’ struck with the pharmaceutical industry to get prescription drug coverage added to Medicare. All three …

Excellent Registry: A Prospective, Multicenter, Global Registry Of Endovascular Stroke Treatment With The Embotrap Device., Raul G Nogueira, Tommy Andersson, Diogo C Haussen, Albert J Yoo, Ricardo A Hanel, Osama O Zaidat, Werner Hacke, Tudor G Jovin, Jens Fiehler, Simon F De Meyer, Waleed Brinjikji, Karen M Doyle, David F Kallmes, David S Liebeskind, Renu Virmani, Malgosia A Kokoszka, Violiza Inoa, William Humphries, Keith B Woodward, Pascal M Jabbour, Olivier François, Elad I Levy, Hormozd Bozorgchami, Stephan Boor, Jose E Cohen, Shervin R Dashti, Muhammad A Taqi, Ronald F Budzik, Clemens M Schirmer, M Shazam Hussain, Laurent Estrade, Reade A De Leacy, Ajit S Puri, Rohan V Chitale, Caspar Brekenfeld, Adnan H Siddiqui

Neuroscience Articles

BACKGROUND: The EXCELLENT registry aimed to evaluate the effectiveness of the EMBOTRAP Revascularization Device in an all-comer population in a real-world setting, with a focus on the composition of retrieved clots.

METHODS: EXCELLENT is a prospective, global registry of patients with acute ischemic stroke treated with EMBOTRAP as the first-line mechanical thrombectomy device conducted at 34 sites (25 sites contributing clot) from September 2018 to March 2021, utilizing core imaging and central histology laboratories blinded to clinical data, independent 90-day modified Rankin Scale assessment and Clinical Events Committee.

RESULTS: After screening 3799 patients, a total of 997 subjects (mean age, …

Quantifying Temperature Effects On Development Rate And Plant Quality Of Compact Container-Grown Tomato, Morgan Humphrey, Ryan W. Dickson, Sonali Padhye

Horticulture Faculty Publications and Presentations

Mean daily temperature effects on plant development rates and quality were evaluated for compact container-grown tomato (Solanum lycopersicum). Compact tomato varieties ‘Siam’ and ‘Red Velvet’ were grown in greenhouses at 18 to 26 °C (Expt. 1) and 20 to 30 °C (Expt. 2) under supplemental high-pressure sodium lighting and 16-h photoperiod. The number of days to first open flower, first ripe fruit and from flower to ripe fruit were measured and development rates calculated by taking the reciprocal (e.g., 1/d). Temperature effects were predicted by fitting a linear (for first open flower) and a nonlinear exponential function (for …

Discordant Discipline: Implications Of State-Legislated Medicine For The Regulation Of Physicians, Kristin Madison

Penn State Law Review (2003 - Present)

No abstract provided.

Comparative Lack Of Accountability: An International Examination Of Covid-19 Vaccine Injury Claim Systems, Lailatul-Mubarakah Imam Aliagan, Mae C. Quinn

Penn State Law Review (2003 - Present)

No abstract provided.

Genetic Architecture Of Cerebrospinal Fluid And Brain Metabolite Levels And The Genetic Colocalization Of Metabolites With Human Traits, Ciyang Wang, Chengran Yang, Daniel Western, Muhammad Ali, Yueyao Wang, Chia-Ling Phuah, John Budde, Lihua Wang, Priyanka Gorijala, Jigyasha Timsina, Agustin Ruiz, Pau Pastor, Maria Victoria Fernandez, Dominantly Inherited Alzheimer Network (Dian), Alzheimer’S Disease Neuroimaging Initiative (Adni), Daniel J Panyard, Corinne D Engelman, Yuetiva Deming, Merce Boada, Amanda Cano, Pablo Garcia-Gonzalez, Neill R Graff-Radford, Hiroshi Mori, Jae-Hong Lee, Richard J Perrin, Laura Ibanez, Yun Ju Sung, Carlos Cruchaga

Faculty, Staff and Student Publications

Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide association study for cerebrospinal fluid (CSF) and brain metabolite levels, identifying 205 independent associations (47.3% new signals, containing 11 new loci) for 139 CSF metabolites, and 32 independent associations (43.8% new signals, containing 4 new loci) for 31 brain metabolites. Of these, 96.9% (CSF) and 71.4% (brain) of the new signals belonged to previously analyzed metabolites in blood or urine. We integrated the metabolite quantitative trait loci (MQTLs) with 23 neurological, psychiatric and common human traits and diseases through colocalization to identify metabolites and biological processes implicated …

Evaluating The Stress System Of The Grieving Brain: Corticotropin-Releasing Factors And Partner Loss In Female Coyotes, Rachel Tong Xin Ning

Undergraduate Honors Capstone Projects

Forming social bonds is fundamental in helping us foster connections with others. The loss of a loved one often results in grief, stress, and loneliness, and the stress response system of the body has been implicated in the physiological symptoms associated with grieving. Corticotropin releasing factor (CRF) is the hormone that initiates the stress response in the body and acts at two different receptor subtypes CRF receptor (CRFR)1 and CRFF2. Many studies on CRF and social loss have been conducted in monogamous prairie voles, but studies in longer-lived monogamous mammals could improve understanding of the effects of losing pair bonds. …

Off-Protocol Radiation Therapy In Phase 3 Metastatic Solid Tumor Trials, Alexander D Sherry, Timothy A Lin, Zachary R Mccaw, Esther J Beck, Ramez Kouzy, Joseph Abi Jaoude, Adina H Passy, Avital M Miller, Gabrielle S Kupferman, Clifton David Fuller, Charles R Thomas, Eugene J Koay, Chad Tang, Pavlos Msaouel, Ethan B Ludmir

Faculty, Staff and Student Publications

Purpose: Increasing data suggest that radiation therapy, particularly ablative radiation therapy, alters the natural history of metastatic disease. For patients with metastatic disease enrolled in prospective trials testing systemic therapy, the use of off-protocol radiation therapy to improve clinical symptoms or extend the duration of study systemic therapy may influence study endpoints. We sought to evaluate how often off-protocol radiation therapy was permitted among systemic therapy phase 3 trials, how often off-protocol radiation therapy is used, and whether off-protocol radiation therapy correlated with study outcomes.

Methods and materials: Two-arm, superiority-design, phase 3 randomized trials testing systemic therapy were screened from …

Prediagnostic Amino Acid Metabolites And Risk Of Gout, Accounting For Serum Urate: Prospective Cohort Study And Mendelian Randomization, Natalie Mccormick, Amit D Joshi, Chio Yokose, Bing Yu, Adrienne Tin, Robert Terkeltaub, Tony R Merriman, Oana Zeleznik, A Heather Eliassen, Gary C Curhan, Hang-Korng Ea, Matthew Nayor, Laura M Raffield, Hyon K Choi

Faculty, Staff and Student Publications

Objective: Our objective was to prospectively investigate prediagnostic population-based metabolome for risk of hospitalized gout (ie, most accurate, severe, and costly cases), accounting for serum urate.

Methods: We conducted prediagnostic metabolome-wide analyses among 249,677 UK Biobank participants with nuclear magnetic resonance metabolomic profiling (N = 168 metabolites, including eight amino acids) from baseline blood samples (2006-2010) without a history of gout. We calculated multivariable hazard ratios (HRs) for hospitalized incident gout, before and after adjusting for serum urate levels; we included patients with nonhospitalized incident gout in a sensitivity analysis. Potential causal effects were evaluated with two-sample Mendelian randomization.

Results: …

The Role Of Lifr Signaling In Innate Immunity, Laura Kahn Serrudo

Dissertations and Theses (Open Access)

The localized signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory cytokines, and differentiation into monocyte-derived dendritic cells (MoDCs), which are required for efficient pathogen eradication.

Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in …

Investigating The Rare Aneuploid Cells In Normal Breast And Therapeutic Resistance In Triple Negative Breast Cancer Using Single Cell Genomics, Yiyun Lin

Dissertations and Theses (Open Access)

Aneuploid epithelial cells are common in breast cancer, however their presence in normal breast tissues is not well understood. To address this question, we applied single cell DNA sequencing to profile copy number alterations (CNAs) in 83,206 epithelial cells from breast tissues of 49 healthy women and single cell DNA&ATAC co-assays to 19 women. Our data shows that all women harbored rare aneuploid epithelial cells (median 3.19%) that increased with age. Many aneuploid epithelial cells (median 82.22%) in normal breast tissues underwent clonal expansions and harbored CNAs reminiscent of invasive breast cancers (gains of 1q, losses of 10q, 16q and …

Economic Disadvantage During Childhood, Obesity, And Diabetes Across Three Birth Cohorts Of Older Mexicans, Jesús-Daniel Zazueta-Borboa, Rafael Samper-Ternent, Rebeca Wong, Neil Mehta

Faculty, Staff and Student Publications

OBJECTIVES: Diabetes prevalence has increased markedly in Mexico. We examined the individual and joint contributions of economic disadvantage during childhood (EDDC) and elevated body weight on diabetes prevalence in 3 cohorts of Mexican adults.

METHODS: Data on those 60-69 years old from the 1930-1939, 1940-1949, and 1950-1959 birth cohorts in Waves 1 (2001), 3 (2012), and 5 (2018) of the Mexican Health and Aging Study were used. EDDC was defined as the absence of a toilet in the household before age 10. Body mass status was defined using self-reported perceived body image at age 50. Diabetes was based on respondent …

The Role Of Ganglioside Gd2 And Gd3 Synthase (St8sia1) In The Regulation Of Immune Suppression In Breast Cancer, Bolutyfe Oderinde

Dissertations and Theses (Open Access)

Gangliosides are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key enzyme that regulates the biosynthesis of the b and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors and plays a role in tumor progression. Similarly, we have previously found GD3S to be significantly upregulated in GD2+ breast cancer stem cells (BCSC) compared to GD2- cells, and the knockdown of …

Smooth Muscle Cell Stress Response: Essential In Atherosclerotic Pathogenesis, Pujun Guan

Dissertations and Theses (Open Access)

Atherosclerosis remains the leading cause of death worldwide. Recent research using lineage tracing and single-cell RNA sequencing unveiled a previously undescribed and prominent role of smooth muscle cells (SMCs) in atherosclerotic plaque formation. SMCs undergo complex phenotypic modulation characterized by de-differentiation of SMCs and heterogeneously increased expression of markers for macrophages, fibroblasts, chondrocytes, and mesenchymal stem cells as plaques form. Cultured SMCs exposed to exogenous cholesterol mimic many of the phenotypic changes associated with plaque formation, and our lab determined this SMC modulation is driven by cholesterol entering the endoplasmic reticulum (ER) and triggering ER stress and PERK signaling. Further, …

Assessing The Temporal Role Of Mir-200 Loss In Murine Models Of Nsclc, Jared Fradette

Dissertations and Theses (Open Access)

Lung cancer is the leading cause of cancer related deaths in the United States, with non-small cell lung cancer (NSCLC) making up a majority of new diagnoses. Metastasis is the big killer in NSCLC and is driven by epithelial-mesenchymal transition (EMT) and immune evasion. The microRNA 200 family is a master regulator of EMT and is implicated in immune regulation. In this study we have developed a novel genetically engineered mouse model (GEMM) and derived primary cell lines from them to explore the role of microRNA-200 in early EMT and immune changes. Our model combines conditional activation of Kras^{G12D …}

Manufacturing Enterprises' Gross Margins And Performance: A Study On The Moderating Effect Of Management Expenses And R&D Expenses, Jiuliu Zhang

Dissertations and Theses Collection (Open Access)

In the context of globalization, manufacturing enterprises are integral to national economies, with their financial stability closely related to increasingly fierce market competition. Among various financial metrics, gross margin stands out as a key indicator of product profitability, significantly impacting production decisions, cost control, and pricing strategies. Understanding the relationship between the gross margins of manufacturing enterprises and their performance is essential for optimizing their financial structures and enhancing their market competitiveness. The study aims to investigate the correlation between gross margin and enterprise performance by developing complex, scientifically sound models and utilizing big data analysis technology. Additionally, it examines …