Digital Commons Network^™

A Multiplex Metabolomic Approach For Quality Control Of Spirulina Supplement And Its Allied Microalgae (Amphora & Chlorella) Assisted By Chemometrics And Molecular Networking, Nesrine Hegazi, Amira R. Khattab, Hamada H. Saad, Bishoy Abib, Mohamed A. Farag

Faculty Journal Articles

Microalgae species are of economic importance regarded as “green gold” being rich in bioactive compounds. Spirulina and Chlorella are the most popular microalgal species and are marketed as healthy food supplements. At the same time, Amphora holds potential as a source of healthy lipids and essential fatty acids. Yet, there are considerable variations in their reported chemical composition, and less is known about their compositional differences. A multiplexed metabolomic approach was adopted for the quality control (QC) of Spirulina supplements and to compare its constitutive metabolome to Chlorella and Amphora. The adopted protocol comprised gas chromatography-mass spectrometry (GC–MS), ultra-high performance …

Enrollment Of Females In Randomized Trials For Glucagon-Like Peptide 1 Receptor Agonists: A Systematic Review, Frederick Berro Rivera, Mc John Caro Ybañez, John Vincent Magalong, Mario Prado, Eloise Arias Aguirre, Ana Patricia Ting Cañares, Janos Marc Rubia, Allyn Ralph Hiyas, Polyn Luz S. Pine, Kyla Lara-Breitinger, Francisco Lopez-Jimenez, Martha Gulati

Ateneo School of Medicine and Public Health Publications

Background

Randomized controlled trials (RCTs) of glucagon-like peptide 1 receptor agonists (GLP-1RAs) form the basis for therapeutic recommendations for both males and females. Historically, females have been significantly underrepresented in RCTs.

Objectives

The authors sought to determine the trends of representation of females in GLP-1RA RCTs from 2007 to 2024.

Methods

We reviewed eligible studies and extracted important variables. The proportion of females among the total participants was obtained per study. This was compared over time (year) of publication and over mean age of participants. This proportion was also compared between specific types of GLP-1RA received, diabetes status, indication of …

Genome-Wide Expression Profiling And Phenotypic Analysis Of Downstream Targets Identify The Fox Transcription Factor Jumeau As A Master Regulator Of Cardiac Progenitor Cell Division, M. Rezaul Hasan

Bakerman Student Research Awards

Forkhead box (Fox) transcription factors (TFs) mediate multiple conserved cardiogenic processes in both mammals and Drosophila. Our prior work identified the roles of two Drosophila Fox genes, jumeau (jumu) and Checkpoint suppressor 1-like (CHES-1-like), in cardiac progenitor cell specification and division, and in the proper positioning of cardiac cell subtypes. Fox TF binding sites are also significantly enriched in the enhancers of genes expressed in the heart, suggesting that these genes may play a core regulatory role in one or more of these cardiogenic processes. We identified downstream targets of Jumu by comparing transcriptional expression profiles of flow cytometry-sorted mesodermal …

The Role Of Trauma-Related Shame In Ptsd And Dissociation, Alexis Stokes

Bakerman Student Research Awards

Dissociation commonly occurs in response to traumatic events, and a dissociative subtype of PTSD is now recognized in the DSM-5. However, researchers have not established a clear consensus as to what factors separate individuals with general PTSD and PTSD with dissociative symptoms (PTSD-D). Negative affect—specifically shame—has been increasingly examined in psychotraumatology research. There is ample evidence that shame predicts and maintains symptom severity in PTSD patients, as well as that it can induce and maintain dissociative symptoms. The clear connection of shame to PTSD and dissociation suggests that it may be an important factor for conceptualizing PTSD-D; however, there is …

Removing Methane Via Soil Amendments: The Legal Framework, Korey Silverman-Roati, Romany M. Webb

Sabin Center for Climate Change Law

Rapid and sustained reductions in human-driven methane emissions are critical to limiting warming in line with the 2015 Paris Agreement. Reductions in certain methane emissions, particularly from the fossil fuel sector, can be implemented cheaply and efficiently. Other forms of methane emissions, like those from agricultural sources, are more difficult to control. This fact, coupled with concerns that climate change could unlock significant additional natural emissions from tropical wetlands and melting permafrost, has increased interest in atmospheric methane removal (“AMR”).

AMR refers to human interventions to accelerate the conversion of methane in the atmosphere to a form that causes less …

The Internist's Post V.1 N.10, The University Of Texas Rio Grande Valley. School Of Medicine, Eunbee Cho, Osiris Fernandez, Hector D. Preciado, Sobia Memon, Diana Acosta Pozo, Corey Haines, Roque Mifuji Lira, Martha Solis, Cesar Gutierrez

School of Medicine Publications

No abstract provided.

Quantifying The Mechanisms Behind Carbon Sequestration And Soil Health Following Compost Application In A Rangeland Chronosequence, Grace Damaschino

Master's Theses

Compost application to rangelands has the potential to sequester carbon (C) and add essential plant nutrients to the soil. The California Department of Food and Agriculture's (CDFA) Healthy Soils Project (HSP) provides financial support to farmers and landowners to implement innovative practices that promote soil health. The CDFA is currently recommending compost application rates of 6-10 tons per acre; however, previous research suggests that degraded soils may require a larger dose of compost to overcome limitations, therefore this recommendation might not meet soil health or soil carbon sequestration objectives. This study examines the compost rate effects on soil health, while …

Advancing Molecular Tools For The Study Of Rubus Viruses, Andrea Sierra-Mejia

Graduate Theses and Dissertations

Since blackberry yellow vein disease (BYVD) was first described, the blackberry virome has expanded significantly. BYVD is a complex disease associated with over ten viruses, yet the role of each virus in its etiology remains understudied. Studying the effect of each virus in disease development requires the identification of single infections; however, this task has been difficult for BYVD, with all field collected material over the past two decades consistently found infected by multiple viruses. Given the diversity of viruses associated with the disease and their different modes of transmission, obtaining pure virus cultures necessitate transmission of individual viruses via …

Effects Of Fast And Slow-Wilting Soybean Genotypes On Plant-Herbivore Interactions, Jessica Ayala

Graduate Theses and Dissertations

Soybean [Glycine max (L.) Merr.] is one of the most important food crops in the world due to its multiple uses in agriculture sector. A major limiting factor in soybean production system is drought stress, causing up to 80% reduction in yield. Due to climate change and associated rise in ambient temperatures, water scarcity is a major concern in crop production, and consequently researchers are turning to soybean accessions that demonstrate better water use efficiency (WUE) traits. However, field grown soybean is also under severe pressure from insect herbivores, often accounting for a 30% reduction in yield. Among these, …

Boise State Magazine, Anna Webb (Editor)

FOCUS on Boise State

No abstract provided.

Aged 539- Internship In Agriculture Education - Waterford High School, Jennifer Pierce

Agricultural Education: Graduate Internship Reports

This report explores the development and implementation of an agricultural education program plan aimed at enhancing student engagement, community involvement, and career readiness. Drawing from established models of program planning and needs assessment, the report focuses on the integration of instructional strategies, supervised agricultural experiences (SAEs) and FFA involvement to foster comprehensive student development. The plan outlines key goals such as increasing student enrollment, improving curriculum alignment with industry standards, and expanding partnerships with local agricultural stakeholders. Strategies include curriculum enhancement, teacher professional development, and the use of data-driven decision-making. The report also emphasizes the importance of evaluation and continuous …

Part Ii. Common Questions And Misconceptions About Creatine Supplementation: What Does The Scientific Evidence Really Show?, Jose Antonio, Ann F. Brown, Darren G. Candow, Philip D. Chilibeck, Stacey J. Ellery, Scott C. Forbes, Bruno Gualano, Andrew R. Jagim, Chad Kerksick, Richard B. Kreider, Sergej M. Ostojic, Eric S. Rawson, Michael D. Roberts, Hamilton Roschel, Abbie E. Smith-Ryan, Jeffrey R. Stout, Mark A. Tarnopolsky, Trisha A. Vandusseldorp, Darryn S. Willoughby, Tim N. Ziegenfuss

Faculty Scholarship

Creatine monohydrate supplementation (CrM) is a safe and effective intervention for improving certain aspects of sport, exercise performance, and health across the lifespan. Despite its evidence-based pedigree, several questions and misconceptions about CrM remain. To initially address some of these concerns, our group published a narrative review in 2021 discussing the scientific evidence as to whether CrM leads to water retention and fat accumulation, is a steroid, causes hair loss, dehydration or muscle cramping, adversely affects renal and liver function, and if CrM is safe and/or effective for children, adolescents, biological females, and older adults. As a follow-up, the purpose …

Synergistic Anticancer Effect Of Pistacia Lentiscus Essential Oils And 5-Fluorouracil Co-Loaded Onto Biodegradable Nanofibers Against Melanoma And Breast Cancer, Obaydah Abd Alkader Alabrahim, Hassan Mohamed El Said Azzazy

Faculty Journal Articles

Chemoresistance and severe toxicities represent major drawbacks of chemotherapy. Natural extracts, including the essential oils of Pistacia lentiscus (PLEO), exhibit substantial anticancer and anti-inflammatory activities where different cancers are reported to dramatically recess following targeting with PLEO. PLEO has promising antimicrobial, anticancer, and anti-inflammatory properties. However, the therapeutic properties of PLEO are restricted by limited stability, bioavailability, and targeting ability. PLEO nanoformulation can maximize their physicochemical and therapeutic properties, overcoming their shortcomings. Hence, PLEO was extracted and its chemical composition was determined by GC–MS. PLEO and 5-Fluorouracil (5FU) were electrospun into poly-ε-caprolactone nanofibers (PCL-NFs), of 290.71 nm to 680.95 nm …

Teachers’ Life Experience Of Trauma And Its Impact In The Classroom, Casey Voelz

All-Inclusive List of Electronic Theses and Dissertations

The purpose of this qualitative study was to determine if teachers’ lived experiences of trauma impact practices, relationships, and responses to student behaviors in the classroom. The common themes could allow colleges, school districts, and school leaders to reflect, develop, or improve access to therapeutic interventions and teacher self-discovery in the areas of self-awareness, self-regulation, and emotional intelligence. This qualitative study involved obtaining data from the Indiana Department of Education. The Indiana Department of Education provided email addresses for superintendents for public schools in Indiana. Superintendents received an email requesting teacher participation. If approved, teachers received the ACE survey. From …

Predicting Newborn Low Birth Weight: A Machine Learning Approach Using Maternal Health And Demographic Data, Rayan Elsayed

Theses

Low birth weight (LBW), defined by the World Health Organization as a birth weight under 2500 grams, remains a major global health challenge due to its association with increased risks for adverse neonatal and long-term health outcomes. This study aims to identify maternal health factors that contribute to LBW and to develop predictive models to support early identification of at-risk pregnancies. Two machine learning models, Logistic Regression (LR) and Random Forest (RF), were developed to analyze the relationship between maternal factors and LBW outcomes. The RF model achieved an accuracy of 96.36%, demonstrating robust predictive performance across metrics, making it …

Robust And Efficient Active Inference For Perception, Action, And Learning, Zhizhuo Yang

Theses

Active Inference (AIF) is an emerging framework rooted in neuroscience aimed at elucidating human perception, action, and cognitive processes. Recent advances in machine learning have facilitated the non-invasive study of human cognition through the lens of this framework. This dissertation expands upon this theoretical foundation to address practical challenges in robotic control and human cognitive behavior analysis. We initiate our exploration with a review of the eye-tracking studies that underpin the motivation for AIF research. This provides a background for understanding how AIF can model cognitive processes. First, we present a minimal AIF model within a discrete state space, framed …

Ecological And Pathological Applications Of The Heat Shock Response, Taylor Rae Stanley

Theses and Dissertations

The heat shock response (HSR) is a cytoprotective stress response pathway that regulates cellular proteostasis. The HSR is an evolutionarily conserved pathway that is essential for normal cellular functioning. Here, we explore the broad ecological and pathological impacts of the HSR. In an ecological context, we perform gene level analysis of the transcriptomes of two closely related sunfish. We found that the more invasive bluegill sunfish has gene expansions in two HSR gene families, the HSP70 family and the HSP90 family compared to the redear sunfish. These gene expansions were also observed in several other teleost fish species and were …

(Featured Artist) The Aromatic Herb Garden, Sophia Samra

The Synapse: Intercollegiate science magazine

No abstract provided.

Evaluating Corn, Tall Fescue And Canola Growth On Sediments Dredged From The Lorain Harbor, Maureen E. Roddy, Emily Kalhert, Corry T. Platt, Ashley N. Julian, Megan A. Rúa

Biological Sciences Faculty Publications

Soil degradation is a worldwide problem, causing the declining performance of many plant species. Recently, the application of sediments dredged from aquatic waterways has received attention for their potential as an organic amendment to revive degraded agricultural soils. In Ohio, dredged sediment research has largely focused on the success of corn (Zea mays) or soybean (Glycine max) following the application of dredged sediments from the Toledo Harbor, neglecting the potential for dredged sediments from the other eight harbors and waterways to change plant performance as well as failing to quantify benefits for other commonly grown crops in the region. In …

Adare-Tasiwoopa Ápi, Sierra And Nathan K. Silva. Gamification In Higher Education: A How-To Instructional Guide. Routledge, 2024, 252 Pages., Willa Swift Black

The Journal of the Assembly for Expanded Perspectives on Learning

Gamification in Higher Education: A How-to Instructional Guide - A Review

The Relationship Between Salvinia Molesta Infestation And The Microbial Ecology Of Wetlands At Caddo Lake, Tx, Usa, Martin Hadsell

Electronic Theses and Dissertations

Wetlands are known to host many beneficial geochemical processes such as nutrient cycling and carbon sequestration. These processes are primarily driven by the microbial communities within a wetland. The establishment of non-native invasive species within wetlands has the potential to alter the once beneficial functionality of wetland microbial communities due to the sensitivity microbes have towards environmental changes. Because of this, several metagenomic studies have been conducted to assess microbial community response to aquatic plant invasion; however, there haven’t been any studies researching the influence of Salvinia molesta (D.S. Mitch.), commonly known as Giant Salvinia, on microbial communities. The goal …

Bioremediation Of Effluent Water In A Coal Ash Disposal Area: Optimizing Microbial Sulfate Reduction, Ryka Shea

Electronic Theses and Dissertations

Coal combustion residues (CCR) pose a serious environmental threat, even long after they are disposed of in specialized landfills, due to their complex composition and potential for leaching into waterways. This study focuses on the issue of elevated sulfate concentrations at the Martin Lake Steam Electric Station (MLSES) A-I Disposal Area in Panola County, Texas, where CCR are disposed of in a permanent landfill. Currently, this site is exceeding its regulatory limit of sulfate concentrations in its effluent and is in need of a cost-effective and sustainable solution to this problem. This research utilized benchtop experiments to investigate sulfate reducing …

Glucagon-Like Peptide-1 Receptor Agonist-Based Agents And Weight Loss Composition: Filling The Gaps, Robert L. Dubin, Steven B. Heymsfield, Eric Ravussin, Frank L. Greenway

Clinical Research Faculty Publications

Excess adiposity is at the root of type 2 diabetes (T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have emerged as first-line treatments for T2D based on significant weight loss results. The composition of weight loss using most diets consists of < 25% fat-free mass (FFM) loss, with the remainder from fat stores. Higher amounts of weight loss (achieved with metabolic bariatric surgery) result in greater reductions in FFM. Our aim was to assess the impact that GLP-1RA-based treatments have on FFM. We analysed studies that reported changes in FFM with the following agents: exenatide, liraglutide, semaglutide, and the dual incretin receptor agonist tirzepatide. We performed an analysis of various weight loss interventions to provide a reference for expected changes in FFM. We evaluated studies using dual-energy X-ray absorptiometry (DXA) for measuring FFM (a crude surrogate for skeletal muscle). In evaluating the composition of weight loss, the percentage lost as fat-free mass (%FFML) was equal to ΔFFM/total weight change. The %FFML using GLP-1RA-based agents was between 20% and 40%. In the 28 clinical trials evaluated, the proportion of FFM loss was highly variable, but the majority reported %FFML exceeding 25%. Our review was limited to small substudies and the use of DXA, which does not measure skeletal muscle mass directly. Since FFM contains a variable amount of muscle (approximately 55%), this indirect measure may explain the heterogeneity in the data. Assessing quantity and quality of skeletal muscle using advanced imaging (magnetic resonance imaging) with functional testing will help fill the gaps in our current understanding.

The Role Of Government Assistance, Housing, And Employment On Postpartum Maternal Health Across Income And Race: A Mixed Methods Study, Chelsea L. Kracht, Kelsey O. Goynes, Madison Dickey, Briasha Jones, Emerson Simeon, Jada Butler, Maryam Kebbe, Kaja Falkenhain, Emily W. Harville, Elizabeth F. Sutton, Leanne M. Redman

Clinical Research Faculty Publications

Background: Stressful large-scale events, such as the COVID-19 pandemic and natural disasters, impact birthing individuals’ postpartum experiences and their mental health. Resultant changes in government assistance, housing, and employment may further exacerbate these impacts, with differences experienced by varying income levels and races. This study aimed to examine maternal depression and anxiety in postpartum individuals by income and race during a stressful large-scale event, and the mediating role of government assistance, housing, and employment. Methods: An explanatory sequential mixed methods study was conducted (QUANT + QUAL). For aim 1 (quantitative), birthing individuals who delivered during peak pandemic (June 2020 - …

Multiomics Analysis To Explore Blood Metabolite Biomarkers In An Alzheimer’S Disease Neuroimaging Initiative Cohort, Takaki Oka, Yuki Matsuzawa, Momoka Tsuneyoshi, Yoshitaka Nakamura, Ken Aoshima, Hiroshi Tsugawa, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer's disease (AD) is a neurodegenerative disease that commonly causes dementia. Identifying biomarkers for the early detection of AD is an emerging need, as brain dysfunction begins two decades before the onset of clinical symptoms. To this end, we reanalyzed untargeted metabolomic mass spectrometry data from 905 patients enrolled in the AD Neuroimaging Initiative (ADNI) cohort using MS-DIAL, with 1,304,633 spectra of 39,108 unique biomolecules. Metabolic profiles of 93 hydrophilic metabolites were determined. Additionally, we integrated targeted lipidomic data (4873 samples from 1524 patients) to explore candidate biomarkers for predicting progressive mild cognitive impairment (pMCI) in patients diagnosed with AD …

Analysis Of Microbiome In Various Human Medical Conditions Using Next-Generation Sequencing Of The 16s Rrna Gene, Pallavi Sharma

Electronic Theses and Dissertations

Studies of human microbiomics, spanning diverse anatomical sites, offer a unique perspective into the complex microbial communities within the body. Influenced by age, gender, and disease, it mirrors broader microbial ecosystems. This study specifically delves into the ocular and gastrointestinal tract microbiome, comparing its composition in 43 healthy and diseased patients using 16S rRNA gene sequencing. We identified a rich microbial landscape, identifying over 338 bacterial taxa. Notably, Acinetobacter, Cutibacterium, Acidovorax and Herbaspirillum were prevalent in the ocular samples and Akkermansia, Faecalibacterium, and Anaerostipes were mostly prevalent in gut samples. Moreover, dry eye disease conditions were characterized by …

Tailoring Ipm Plans To Fight A Cloaked Pest: Helping Smallholder Farmers Combat The Sweetpotato Weevil In Sub-Saharan Africa, Chad A. Keyser, Frederick S. Walters, Haley Turner, Elka Armstrong, Jeff Davis, Brooke Bissinger, Brant Johnson, Agnes Alajo, Paul Musana, Joseph Odongo, Benard Yada, Milton A. Otema

Faculty Publications

Africa accounts for a significant portion of the world’s sweetpotato production where it is widely grown as a staple crop. In sub-Saharan Africa (SSA), sweetpotato serves as an important year-round source of calories and nutrition, a form of income for smallholder and pre-commercial farmers, and is increasingly used as silage for animal feed. However, yield per hectare is considerably lower in SSA than from other regions primarily due to sweetpotato weevils (SPW, Cylas spp., Coleoptera: Brentidae). Weevil feeding causes physical damage to the root and can induce chemical responses that give the storage root a bitter taste, both of which …

Vegetation Dieback In The Mississippi River Delta Triggered By Acute Drought And Chronic Relative Sea-Level Rise, Tracy Elsey-Quirk, Austin Lynn, Michael Derek Jacobs, Rodrigo Diaz, James T. Cronin, Lixia Wang, Haosheng Huang, Dubravko Justic

Faculty Publications

Coastal wetlands are vulnerable to sea-level rise. Here, the authors use 16 years of data to correlate vegetation dieback in the Mississippi River Delta to drought-induced salt water intrusion in the summer of 2012.

Resilient, Environment Tolerant And Biocompatible Electroluminescent Devices With Enhanced Luminance Based On Compliant And Self-Adhesive Electrodes, Ya Lu, Yuanyuan Chen, Haoyu Sun, Fang Deng, Changtong Mei, Xinwu Xu, Qinglin Wu, Huining Xiao, Yiying Yue, Jingquan Han

Faculty Publications

Electroluminescent (EL) devices are of great significance for expanding the application range of optoelectronics. However, the realization of EL devices with environment-tolerance, stretchability, mechanical cycling stability, self-adhesion, biocompatibility, and high dielectric constant still remains a challenge. Herein, a type of EL device with enhanced comprehensive performances composing of a chlorinated barium titanate/phosphor/polydimethylsiloxane (Cl-BT/phosphor/PDMS) luminescent layer sandwiched between two silver nanowire-cellulose nanocrystal with II crystalline allomorph/Triton X-100 modified polydimethylsiloxane (AgNW-CNC II/TX-PDMS) electrodes fabricated through a full solution-processing strategy is proposed. Environmentally-friendly CNC II with high transmittance acts as an antioxidant, dispersant and film-former for AgNWs. The hydrophilic modification of TX to …

Reply To Myers And Rosser: A Comment About Studying The Health Effects Of Smoke Produced By Prescribed Fire, Dwan Vilcins, Wen R. Lee, Tamara L. Blake, Wenbo Wu, Stephania Cormier, Peter D. Sly

Division of Basic Science Faculty Publications

No abstract provided.