Control Intervention Design For Preclinical And Clinical Trials: Consensus-Based Core Recommendations From The Third Stroke Recovery And Rehabilitation Roundtable, Kathryn S Hayward, Emily J Dalton, Jessica Barth, Marian Brady, Leora R Cherney, Leonid Churilov, Andrew N Clarkson, Jesse Dawson, Sean P Dukelow, Peter Feys, Maree Hackett, Steve R Zeiler, Catherine E Lang

2020-Current year OA Pubs

Control comparator selection is a critical trial design issue. Preclinical and clinical investigators who are doing trials of stroke recovery and rehabilitation interventions must carefully consider the appropriateness and relevance of their chosen control comparator as the benefit of an experimental intervention is established relative to a comparator. Establishing a strong rationale for a selected comparator improves the integrity of the trial and validity of its findings. This Stroke Recovery and Rehabilitation Roundtable (SRRR) taskforce used a graph theory voting system to rank the importance and ease of addressing challenges during control comparator design. "Identifying appropriate type of control" was …

The Importance Of Acoustic Output Measurement And Monitoring For The Replicability Of Transcranial Ultrasonic Stimulation Studies, Miriam C. Klein-Flügge, Elsa F. Fouragnan, Eleanor Martin

School of Psychology

No abstract provided.

Exposure To Air Pollution And Risk Of Respiratory Tract Infections In The Adult Danish Population—A Nationwide Study, Kathrine A. Kaspersen, Sussie Antonsen, Henriette T. Horsdal, Bertram Kjerulff, Jørgen Brandt, Camilla Geels, Jesper H. Christensen, Lise M. Frohn, Clive E. Sabel, Khoa M. Dinh, Ole Hertel, Torben Sigsgaard, Carsten B. Pedersen, Christian Erikstrup

School of Geography, Earth and Environmental Sciences

Objectives: The association between air pollution and risk of respiratory tract infection (RTI) in adults needs to be clarified in settings with low to moderate levels of air pollution. We investigated this in the Danish population between 2004 and 2016. Methods: We included 3 653 490 persons aged 18–64 years in a nested case-control study. Exposure was defined as the average daily concentration at the individual's residential address of CO, NO_X, NO₂, O₃, SO₂, NH₃, PPM_2.5, black carbon, organic carbon, mineral dust, sea salt, secondary inorganic aerosols, SO …

Association Of Life History Strategy And Mate Retention Behavior In Men And Women, Sepide Pazhouhi, Ray Garza, Farid Pazhoohi

School of Psychology

From an evolutionary perspective, both men and women use a variety of guarding tactics to keep their romantic partners in the relationship. For men, these benefits increase paternity certainty, while for women, they guarantee male investment in the woman and her children. The current research aimed to explore the association between life history strategy (LHS) and mate retention behaviors in men and women from Iran and the UK. We hypothesized that individuals with a slower life history strategy will show a positive association with benefit-provisioning mate retention (e.g., gift-giving, affection), and a negative association with cost-inflicting mate retention (e.g., emotional …

Everyday Places To Get Away – Lessons Learned From Covid-19 Lockdowns, B. Gatersleben, Emma V. White, K.J. Wyles, S.E. Golding, G. Murrell, C. Scarles, T. Xu, B.F.T. Brockett, C. Willis

School of Psychology

Being able to get away from everyday stressors and demands, even if close to home and just for a few minutes, is important for wellbeing. During the Covid-19 lockdown periods, people's ability to get away changed significantly. An increase in visits to nearby natural places is well documented. Little is known about other types of places people visited to get away. An online UK survey was conducted in 2020 (N = 850) investigating what places people visited to get away during the pandemic, what they did in those places, how place and activity choices were related to each other and …

Child Protection And Family Support: Experiences In A Seaside Resort, Thomas El-Hoss, Felicity Thomas, Felix Gradinger, Ms Susanne Hughes

Peninsula Medical School

Effective Early Help services are key to halting rising rates of children in care in the UK. Yet despite family support and child welfare interventions being unequally distributed across the country, the role of ‘place’ has received limited attention in the children's social care arena. This paper examines the connections between coastal challenges, Early Help and child welfare interventions, drawing on embedded research undertaken within a Local Authority on England's coast with elevated levels of children in care. We focus on families’ experiences raising children in a seaside resort area as well as professionals’ perspectives on the place-based challenges faced …

Atmospheric Deposition Of Microplastics In Shiraz, Iran, Sajjad Abbasi, Farnaz Ahmadi, Nafiseh Khodabakhshloo, Haniye Pourmahmood, Atefeh Esfandiari, Zeinab Mokhtarzadeh, Shaqayeq Rahnama, Reza Dehbandi, Arya Vazirzadeh, Andrew Turner

School of Geography, Earth and Environmental Sciences

The atmosphere plays a critical role in the regional and global transportation and redistribution of microplastics (MPs). However, the significance of rainfall and its means of scavenging MPs are not well understood. In this study, MP deposition was determined during successive dry and rainy events over eight consecutive days in the Shiraz region of Iran. Flux magnitudes and temporal distributions at six sites within and outside the city (including a remote, non-urbanised location) were similar and revealed a progressive increase in MP abundance and deposition during dry periods (up to about 50 MP m−2 h−1) and subsequent relatively rapid wet …

Contrasting Species-Specific Stress Response To Environmental Ph Determines The Fate Of Coccolithophores In Future Oceans, Nishant Chauhan, Craig J. Dedman, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Rosalind E.M. Rickaby

School of Geography, Earth and Environmental Sciences

Molecular mechanisms driving species-specific environmental sensitivity in coccolithophores are unclear but crucial in understanding species selection and adaptation to environmental change. This study examined proteomic and physiological changes in three species under varying pH conditions. We showed that changing pH drives intracellular oxidative stress and changes membrane potential. Upregulation in antioxidant, DNA repair and cell cycle-related protein-groups indicated oxidative damage across high (pH 8.8) and low pH (pH 7.6) compared to control pH (pH 8.2), and correlated with reduced growth rates. Upregulation of mitochondrial proteins suggested higher metabolite demand for restoring cellular homeostasis under pH-induced stress. Photosynthetic rates generally correlated …

Peer Inclusion And School Equality Norm Associations With Intergroup Contact, And Academic Self-Efficacy Amongst Ethnic Majority And Ethnic Minority Youth, Shelley Mckeown, Gian Antonio Di Bernardo, Jaysan Charlesford, Loris Vezzali, Thia Sagherian-Dickey

School of Psychology

Social norms are important predictors of youth attitudes and behaviours. There is substantial evidence that positive and meaningful intergroup contact supported by inclusive norms can have a range of benefits beyond prejudice reduction. The present research explores whether perceived peer inclusion norms and perceived norms of equality in school are associated with better quality and more frequent intergroup contact and in turn, whether these are associated with better academic self-efficacy. To test these assertions, we conducted a cross-sectional survey with ethnic majority and ethnic minority youth aged 11–12 (n = 629, 48% female, 43% minority ethnic) attending one of four …

The Experiences Of Women College Presidents While Leading Through An Institutional Crisis: The Perceived Successes And Failures Of Crisis Communication Strategies, Madison Marie Speck

Graduate Theses, Dissertations, and Problem Reports (ETD)

This multi-site case study explored the uncommonly discussed yet organic intersection between the study of crisis communication and the study of crisis leadership and in turn, what it means in the context of a college presidency. This study has a unique focus on women presidents at small, private colleges and the ways in which they communicate with various stakeholders during a crisis environment. The research is guided by Boin’s Model of Crisis Leadership which guides and assesses crisis leadership performance; however this study introduces nuances to the framework that are suggested as a result of the findings; most of which …

Abuse Liability Of Electronic Cigarettes In Non-Smoking Electronic Cigarette Users, Andrea Renee Milstred

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electronic cigarettes (ECIGs) are devices designed to aerosolize nicotine and are increasing in popularity among both former cigarette smokers and naïve tobacco users. Extant research has shown the dependence potential of ECIGs, though there is not a consensus on the severity of nicotine dependence caused by ECIG use. As a result of becoming dependent on nicotine, individuals may experience withdrawal symptoms (i.e., irritable, craving, depressed mood) when abstaining from nicotine. The majority of previous research on ECIG use has included samples of ECIG users who are former or current smokers. The present study evaluated ECIG withdrawal suppression among a population …

The Function Of Protein Glutamylation In Vision, Rawaa Aljammal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Posttranslational glutamylation of protein has emerged as a novel candidate for cellular integrity. In a dynamic process, Tubulin Tyrosine Ligase Like proteins (TTLLs) introduce glutamate groups to their substrates, while Cytosolic Carboxypeptidases members (CCP1-CCP6) remove these glutamate groups. The outcome of this interplay is a wide range of substrates; each is glutamylated to a level crucial for its function.

Protein glutamylation is particularly abundant in neurons and in the axoneme of cilia and flagella. This distribution, along with the correlation between imbalanced glutamylation levels and compromised cellular functions, underscores the significance of protein glutamylation in maintaining cellular viability. However, the …

Subjective Cognitive Decline: Examining The Contributions Of Adverse Childhood Experiences And Social Determinants Of Health, Amber Victoria Rusch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Subjective cognitive decline is one’s awareness of their own consistent memory loss or confusion that interrupts their day-to-day activities (CDC, 2022; Roehr et al., 2017). Several risk factors for subjective cognitive decline, such as demographic social determinants of health (SDOH) and adverse childhood experiences (ACEs) have been identified through previous research (Alzheimer’s Association, 2016; Dening & Sandilyan, 2015); however, less is known about the interaction between demographic SDOH and ACEs on subjective cognitive decline. The current study sought to examine how demographic SDOH (i.e., age, sex, race, and education) (research question 1) and ACEs (i.e., physical abuse, sexual abuse, and …

A Critical Event Narrative Analysis Of African Women Immigrant Entrepreneurs In The United States: Impacts Before, During, And After The Covid-19 Pandemic, Damilola T. Fasinu

Graduate Theses, Dissertations, and Problem Reports (ETD)

This doctoral research presents a qualitative critical event narrative study focused on African Women Immigrant Entrepreneurs (AWIE) in the United States during the COVID-19 pandemic. The study aims to explore the unique challenges, coping mechanisms, and resilience strategies of AWIE by examining their experiences before, during, and after the pandemic. The research is driven by three guiding questions: (1) How do AWIE describe their experience before the pandemic? (2) During the pandemic? (3) After the pandemic? This inquiry provides a comprehensive narrative, capturing the challenges and successes experienced in the pre-pandemic environment, documenting the immediate impacts of the pandemic on …

Associations Among Psychosocial Factors, Health-Related Quality Of Life, And Adherence In Pediatric Inflammatory Bowel Disease, Cecelia I. Nelson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inflammatory Bowel Disease (IBD) is a prevalent disorder among youth in the United States. IBD is one of the leading causes of chronic pain in adolescence and symptoms can lead to reduced quality of life, social embarrassment, and lower self-esteem. Adherence to medical regimens for IBD is incredibly important to prevent morbidity, mortality, and impaired health-related quality of life (HRQOL). However, adolescents struggle generally with adherence and the regimen for IBD can be complicated and include aversive side effects. Psychological factors, such as depressive symptoms, are key factors associated with non-adherence. Nevertheless, gut-specific anxiety (GSA) is a psychological factor that …

Treatment Patterns And Clinical And Economic Burden In Patients With Merkel Cell Carcinoma: Statistical And Machine Learning Approaches, Yves Mbous

Graduate Theses, Dissertations, and Problem Reports (ETD)

Although considered a rare form of nonmelanoma skin cancer, Merkel Cell Carcinoma incidence rate has increased to 0.74 per 100,000 and projections expect this number to steadily rise over the next decades and to reach an average of 3,285 cases per year in 2025. MCC incidence increases significantly with age. Among those aged 40-44, it is 0.44, it rises to 1.0/100,000 in the 60-64 age group and soars to 9.8/100,000 among those ≥85 years and above. Due to the small number of cases, MCC is often managed using institutional practices or provider preferences. Formal clinical trials that enroll early stage …

Seeing Red: Hostile Attribution Bias, Aggression, And Antisocial Personality Disorder Traits, Kaley Potter

Graduate Theses, Dissertations, and Problem Reports (ETD)

Antisocial personality disorder (ASPD) is a destructive and severe mental illness that costs the U.S. trillions of dollars annually. Although ASPD is significantly correlated with acts of aggression, violence, and imprisonment, not all individuals with ASPD are aggressive. In samples without ASPD, increased aggression has been linked to an error in social information processing, which is referred to as hostile attribution bias (HAB).

The current study tested the extent to which HABs, or the tendency to attribute hostility to neutral or ambiguous stimuli, predicted aggression above and beyond ASPD traits in participants with a history of incarceration. Participants (N = …

Parental Socialization Of General And Domain-Specific Self-Control In Adolescents, Matty Johnston

Graduate Theses, Dissertations, and Problem Reports (ETD)

Adolescent self-control appears to be an important competency to develop. It has pervasive links with various outcomes (e.g., educational, financial, and interpersonal) both during adolescence and into adulthood (Allemand et al., 2019, Moffitt et al., 2011). Adolescents often report lower self-control compared to adults, although individual levels of self-control vary widely between adolescents (Allemand et al., 2019, Romer et al., 2010). Despite its importance, very little is known about how self-control develops. Thus, the current study aims to examine the relationship between parents’ self-control and that of their teen children. To further understand how adolescents' self-control may be socialized by …

Depicting The Donald: How Framing Of Donald Trump In Media Changed Throughout The Course Of His 2015-2016 United States Presidential Campaign, Jakob O. Janoski

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examined how framing of Donald Trump in online news images may have changed throughout the course of his 2015-2016 United States presidential campaign. Previous research suggests that Republican presidential candidates may get more coverage but not necessarily be framed as more favorable (Moriarty and Popovich, 1988). The content analysis comprised of 18 constructed weeks in which images from various outlets were analyzed in nine categories (e.g., “facial expression” and “posture”) and coded as either “more favorable,” “N/A” or “less favorable.” It was found that image favorability of Trump dipped from the Pre-Primary period to the Primary period then …

Intervention To Reduce Tobacco Use Among Prostate Cancer Patient And Informal Caregiver Dyads, Trupti Dhumal

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prostate cancer is the leading cancer in men. Continued tobacco use after prostate cancer diagnosis may affect a patient’s treatment outcomes, quality of life, and mortality. Despite the potential negative outcomes, 10-20% of prostate cancer patients continue to use tobacco after their cancer diagnosis. Considering risks associated with continued tobacco use, there is a lack of evidence-based tobacco cessation strategies to address tobacco cessation specifically in prostate cancer. Given the increasing prevalence of prostate cancer, the ongoing difficulty in tobacco cessation, and the limited evidence-based tobacco cessation interventions in the literature, it is important to prioritize reducing tobacco use in …

Modeling, Control, And Fault Detection Of Energy Systems Under Limited High-Confidence Data Scenarios, Selorme K. Agbleze

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Modeling, Control, and Fault Detection of Energy Systems under Limited High-Confidence Data Scenarios

Selorme K. Agbleze

Utilizing process measurements for fault detection is an established approach for processes with adequate datasets. For systems with limited high-confidence data representing fault cases and some amount of low-confidence data, few quantitative hybrid techniques exist for performing fault detection. In real systems, it is time-consuming, expensive, and sometimes not productive to generate enough high-confidence data with fault characteristics of a specific process. The problem of limited high-confidence data scenarios may also arise due to process novelty, the need for new operating conditions, or …

First Amendment Disequilibrium, Christina Koningisor, Lyrissa Lidsky

Faculty Scholarship

The Supreme Court has constructed key parts of First Amendment law around two underlying assumptions. The first is that the press is a powerful actor capable of obtaining government information and checking government power. The second is that the executive branch is bound by various internal and external constraints that limit its ability to keep information secret. Judges and legislators have long assumed that these twin forces—an emboldened press and a constrained executive—maintain a rough balance between the press’s desire to uncover secrets and the executive’s desire to keep information hidden. Landmark First Amendment cases such as the Pentagon Papers …

Empirically Assessing Medical Device Innovation, George Horvath

Faculty Scholarship

No abstract provided.

Dance Of The Biologics, Robin Feldman, Gideon Schor

Faculty Scholarship

From COVID-19 vaccines to cancer treatments, biologic medicines are gaining importance in the U.S. health care system. Their high price tags, however, make these medications difficult for many Americans to afford. The Biosimilars Act, enacted in 2010, aimed to reduce costs and increase access to biologic medications by encouraging follow-on competition. The legislative effort followed in the footsteps of its predecessor, the Hatch-Waxman Act of 1984.

Although the Hatch-Waxman system succeeded in creating a landscape of more affordable and widely used generic drugs, the Biosimilars Act has failed to live up to its promise. Biologic drugs in the United States …

Just Look At The Map: Bounding Environmental Review Of Housing Development In California, Eric Biber, Christopher S. Elmendorf, Nicholas Marantz, Moira O’Neill

Faculty Scholarship

California faces a dire housing crisis. California’s land-use regulatory system remains a key driver of this crisis. State law grants local governments broad power to craft their own regulations on how to review and approve housing development. Though state law may limit a locality’s ability to outright deny some types of housing development, local governments can and do use creative ways to stall approvals or functionally deny housing by making it infeasible to develop. One such strategy is to demand more intensive environmental review of new housing projects under the California Environmental Quality Act (CEQA) than what state law requires. …

The Illusion Of Progress: Rethinking Human Rights And The Legal Regulation Of Mobility, Moria Paz

Faculty Scholarship

The development of human rights law is generally presented as a story of progress. This progress is an evolution from an “old” legal regime that did not recognize individual rights to a “new” law (starting with the 1948 Universal Declaration of Human Rights (UDHR)) that anointed all individuals as possessors of internationally recognized rights against their states. Further, the definition of these rights has supposedly expanded over time, adding elements of complementary protection and extraterritorial application.

However, at least as it concerns border-crossing, this standard genealogy is wrong. The story of human rights is, in fact, one of retreat—a contraction …

First Amendment Disequilibrium, Christina Koningisor, Lyrissa Lidsky

Faculty Scholarship

The Supreme Court has constructed key parts of First Amendment law around two underlying assumptions. The first is that the press is a powerful actor capable of obtaining government information and checking government power. The second is that the executive branch is bound by various internal and external constraints that limit its ability to keep information secret. Judges and legislators have long assumed that these twin forces—an emboldened press and a constrained executive—maintain a rough balance between the press’s desire to uncover secrets and the executive’s desire to keep information hidden. Landmark First Amendment cases such as the Pentagon Papers …

Major Questions About Presidentialism: Untangling The 'Chain Of Dependence' Across Administrative Law, Jodi L. Short, Jed H. Shugerman

Faculty Scholarship

No abstract provided.

Making Social Security Progressive, Manoj Viswanathan

Faculty Scholarship

Social Security is funded by a regressive tax in which wages below the wage cap ($160,200 in 2023) are taxed at a flat rate but wages above the cap are taxed at zero. To address this normative shortcoming and make Social Security progressive, this Piece proposes eliminating the wage cap and using the resulting additional revenue to fund a zero-rate Social Security tax bracket analogous to the standard deduction of the federal income tax. IRS data show that these changes could fund an exemption of at least $10,000, thereby saving low-wage taxpayers approximately $1,200. By altering only the distribution of …

The Intrusive State: Restrictions On Gender-Affirming Healthcare For Minors, Exceptions To The Doctrine Of Parental Consent, And Reliance On Science And Medical Expertise, Lois A. Weithorn

Faculty Scholarship

The provision of gender-affirming medical care to transgender or gender diverse (“TGD”) youth is currently the subject of substantial controversy despite an overwhelming consensus in the healthcare community as to the safety and potential benefits of recommended treatments. Much of the debate is fueled by misinformation and inaccurate characterization of research and practice. Against this backdrop, twenty-three states enacted restrictions or complete prohibitions on access to gender-affirming medical care for adolescents between 2021 and the time of this writing in early 2024. The policies typically place healthcare practitioners who provide such services at risk of license revocation. Some statutes create …