Digital Commons Network^™

Development Of Novel Nanocarriers With Multi Modal Action Against Lung Cancer, Gayathri K

Theses and Dissertations

Lung cancer ranks among the top causes of cancer-related deaths worldwide. The deteriorating environment and unhealthy lifestyle in the modern era has further contributed to the exponential increase in lung cancer incidence across the globe. Lung cancers fall under two major types based on the location of the tumour in the lung namely, small-cell lung cancer (SCLC) which is more aggressive, and non-small-cell lung cancer (NSCLC) which is more prevalent. Late diagnosis has been a major cause for poor prognosis as the cancer is detected only in an advanced stage.

Conventional therapies like chemotherapy, surgery and radiotherapy against lung cancer …

What Is The Value Of The Child And Dependent Care Credit?, Gabrielle Pepin

Upjohn Institute Working Papers

The Child and Dependent Care Credit (CDCC) subsidizes child care costs for working families. In response to the Covid-19 pandemic, the American Rescue Plan Act of 2021 increased the CDCC’s generosity during 2021 only. I find that while the CDCC is of relatively little value in its current form, increases in eligibility rates and conditional benefits under the pandemic expansion increased the credit’s value dramatically. Conditional on CDCC eligibility, higher-income households experienced the largest increases in benefit levels under the expanded CDCC, but lower-income households benefited disproportionately when measuring benefits as a share of income or child care spending.

Policing And Media: Past, Present, And Future, Mark Deratzou

Theses

This paper examines the historical relationship between policing and media, with a focus on how media has influenced policing within the United States. It begins by examining portrayals of policing in print and broadcast media, as well as major historical events, before discussing how media influences public perceptions of police. The paper then transitions to an examination of social media, focusing on how these platforms shape perceptions of police and how they are used by the public in relation to policing. The paper then concludes with a discussion of policing and media-related policies and reforms, as well as considerations for …

Assessing Ecosystem Health Of A Completed Mitigation Bank Projects In California: Case Study Analysis, Alexandra I. Novoa

Master's Projects and Capstones

Wetlands are among the most productive ecosystems in the world, providing essential ecological functions. These functions include water purification, flood protection, shoreline stabilization, and more. Due to increasing urbanization and development, preserving wetlands is critical. Mitigation Banks combat the loss of wetland acreage from unavoidable development. Mitigation banks were developed to offset the adverse effects of development on wetlands. However, more research is needed on the effectiveness of these mitigation banks in restoring ecologically significant wetland acreage.

Key metrics, including soil health, hydrology, and microbial functionality, were analyzed from literature and restoration project reviews to identify opportunities for improving mitigation …

Does The Use Of Platelet Rich Plasma (Prp) Improve The Likelihood Of Embryo Implantation And Advancement To Pregnancy In Those Struggling With Recurrent Failure By Ivf?, Andrea Winter, Sophia Levine

Physician Assistant Capstones, 2020-current

No abstract provided.

Board Of Trustees Minutes, December 13, 2024, Coastal Carolina University

Board of Trustees Meeting Minutes

No abstract provided.

Administration, Governance And Advancement Committee, December 12-13, 2024, Coastal Carolina University

Board of Trustees Committee Minutes

No abstract provided.

A Kinetic Model For Compound Heterozygous Pathogenic Variants In Tyrosyl-Trna Synthetase Gene Yars2-Associated Neonatal Phenotype, Thomas W Christian, Sunita Maharjan, Sitao Yin, Yuka Yamaki, Isao Masuda, Fenglin Li, Colleen Muraresku, Sheila Clever, Rebecca Ganetzky, Ya-Ming Hou

Department of Biochemistry and Molecular Biology Faculty Papers

Human genetic disorders are often caused by mutations of compound heterozygosity, where each allele of the mutant gene harbors a different genetic lesion. However, studies of such mutations are hampered due to the lack of an appropriate model. Here we describe a kinetic model of compound heterozygous variants in an obligate enzyme dimer that contains one mutation in one monomer and the other mutation in the second monomer. This enzyme is encoded by human YARS2 for mitochondrial tyrosyl-tRNA synthetase (mt-TyrRS), which aminoacylates tyrosine to mt-tRNA^Tyr. YARS2 is a member of the genes for mt-aminoacyl-tRNA synthetases, where pathogenic mutations …

The Shaky Democratic Legitimacy Of Cosmopolitan Law And Its Destiny In Times Of Crisis, Sergio Dellavalle

Buffalo Law Review

From its earliest introduction in 1795, the notion of cosmopolitan law has made a long way, to finally become an established reference point in the legal discourse. Nonetheless, the concept still raises four fundamental questions. The first focuses on how it has been developed and which were the fundamental authors and theoretical steps that characterized the emergence of this notion. The second and most essential question refers to the meaning of cosmopolitan law by focusing on what characterizes the legal norms that we call cosmopolitan as well as on what distinguishes them from the broader field of traditional international law. …

Improving Compliance In Missed Visits Documentation, Ma Rosalie Felix

Master's Projects and Capstones

Problem: Within the South Bay Hospice Agency, documentation compliance for missed visits was 68% in the first quarter of 2024, when the national standard should be 100% according to the Centers for Medicare & Medicaid Services.

Context: Inadequate nurse documentation and communication between health professionals can lead to medical errors, poor team communication and suboptimal patient outcomes (Tasew et al., 2019). Therefore, the importance of documentation compliance is imperative. Hospice staff perform scheduled visits for terminally ill patients 1-2 times a week; however, a missed visit can occur when a patient declines it for a variety of reasons.

Interventions: The …

Interventions In Treating Ptsd As A Result Of Birth Trauma, Christine Marie Samatra-Montalvo

Master's Projects and Capstones

This paper explores the prevalence, causes, and consequences of PTSD resulting from childbirth, highlighting the need for effective intervention strategies. A systematic review of 25 studies encompassing cognitive-behavioral therapy (CBT), eye movement desensitization and reprocessing (EMDR), pharmacotherapy, and support groups was conducted to evaluate their effectiveness. Findings indicate that CBT and EMDR are the most promising treatments, with pharmacotherapy and support groups also providing substantial benefits. However, access to these interventions remains a challenge for certain populations. This paper underscores the importance of tailored, trauma-informed care and suggests that comprehensive maternal mental health programs can significantly improve outcomes for mothers …

Design And Synthesis Of Bimetallic Catalyst And Multifunctional Peptide Catalysis For Organic Synthesis And Synthesis Of Proteolysis Targeting Chimeras (Protacs) For Sphk1 And Sphk2, Mariur Rodriguez Moreno

Theses and Dissertations

In the first part of this dissertation (chapters 1-4) we discuss the development of bimetallic and monometallic palladium complexes scaffolded on 2-phosphinoimidazole ligands and their application to cross-coupling reactions. Specifically, we discovered a bimetallic Pd(II) dimer that performs a tandem arylation/annulation reaction to produce naphthalene products from aryl iodides and ketones (Chapter 2). We then show that bimetallic Pd(II) and Pd (I) complexes have different activity in different transformations and that the starting oxidation state of our catalysts is important for reactivity (Chapter 3). For example, we demonstrate that our Pd(I) dimer is much more active in Buchwald- Hartwig amination …

Adolescent Suicide Prevention Techniques, Kaitlyn R. O’Malley

Honors Capstones

The purpose of this paper is to understand prevention techniques for adolescent suicide. Suicide is defined as death caused by injuring oneself with the intent to die. Suicide is the fourth leading cause of death among 15–29-year-olds (WHO). From 2021 to 2022, the number of suiciderelated deaths increased by 2.6%. 48,123 people died from suicide in 2021 alone. (CDC) From 2011-2021, 13% of high school girls tried to commit suicide, and 30% of them considered trying (Youth Risk Behavior Survey Data Summary and Trends Report: 2011–2021). Suicide is very preventable in society, which is why, with how many people try …

Msw Portfolio, Melissa Sue Wells

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio showcases examples of the work I have completed throughout my master's program.

Persons Or Human-Mimicking Robots? Implications Of Ai For Moral Status, Kate Burckle, Catherine Peters

Honors Thesis

Rapid progress in the field of Artificial Intelligence (AI), in which AI technologies can now perform human tasks, e.g. hold advanced conversations, cook, clean, and navigate harsh terrain, blurs the line between humans and robots. The emergence of advanced AI technologies suggests that AI programs may develop consciousness in the near future, prompting important questions: if AIs attain abilities to perform the same tasks and exercise capacities traditionally limited to humans, do they deserve similar moral status? If so, what treatment would we owe to them? Through examination of competing accounts of personhood and moral status, this paper seeks to …

Annual Comprehensive Financial Report, Washington County, Tennessee For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Annual Financial Report Williamson County, Tennessee For The Year Ended June 30, 2024, Tennessee. Comptroller Of The Treasury.

Tennessee County Audit Reports

No abstract provided.

Oregon State Rank Assessment For Mardon Skipper (Polites Mardon), Eleanor P. Gaines

Institute for Natural Resources Publications

Oregon state conservation status assessment for Mardon skipper (Polites mardon) using NatureServe methodology, 2024.

Assessing Ocean Attitudes, Decision-Making, And Learning Of Oceanography Camp Especially For Girls Participants, Serenity Poston-Hymel

USF St. Petersburg campus Honors Program Theses (Undergraduate)

The ocean provides many important economic, nutritional, and cultural resources and ecosystem services to human populations. However, many anthropogenic activities are threatening ocean ecosystems and these vital resources (Inniss et al., 2016). Ocean literacy is the knowledge, attitude, and behaviors that pertain to the ocean, its systems, and its relationships with humans (Brennan et al., 2019; Schoedinger et al., 2005). A key goal of ocean literacy is encouraging informed decisions and behaviors pertaining to the ocean, leading to responsible management and use of ocean resources (Santoro et al., 2018). Ocean attitudes and environmental moral reasoning are vital in influencing positive …

2024-12-13, Board Of Regents, Murray State University

Board of Regents Meeting Minutes

No abstract provided.

Retrieving The Information Stored In The Donated Organ May Cause The Patient’S Personality To Change After The Transplant Operation, Jamal Al-Karaki, Muhammad Al-Zafar Khan, Phoka Rathebe, Raul Valverde, Alireza Sepehri, Massimo Fioranelli

All Works

The results of some scientific research show that organ transplantation, especially heart transplantation, causes changes in the patient’s personality and even memory. These changes can be due to the recovery of information stored in the donor’s molecules and cells. In fact, as in the orchestrated objective reduction model, information in the form of polarization or spin of molecules, electrons, and photons is stored in microtubules due to the connection between the brain and the heart through blood vessels and nerves, and waves. A copy of the information is stored in molecules and heart cells and possibly through the induction of …

Parent And Primary Care Clinician Perceptions About Pediatric Hypertension, Abbas H. Zaidi, Erica Sood, Sarah De Ferranti, Samuel Gidding, Varsha Zadokar, Jonathan Miller, Anne Kazak

Department of Pediatrics Faculty Papers

IMPORTANCE: Despite published guidelines and a prevalence of pediatric hypertension of approximately 3%, less than 25% of affected children are identified, with 60% not receiving any intervention despite detection. Understanding the knowledge and perceptions of parents or caregivers and health care teams is crucial to identify factors that may contribute to these unacceptably low detection rates.

OBJECTIVE: To examine the knowledge and perceptions of parents and health care teams regarding pediatric hypertension to identify common themes contributing to low hypertension detection.

DESIGN, SETTING, AND PARTICIPANTS: This qualitative study, interviewed parents of children diagnosed with hypertension who did not follow up …

Training Staff Members And Caregivers On Utilizing Allen Cognitive Levels To Aid Individuals Living With Alzheimer's And Dementia To Maintain Activities Of Daily Living, Kristy Boyd

Student Capstone Papers

This capstone is about training caregivers and staff members on utilizing the Allen Cognitive Levels to help individuals living with Alzheimer's and Dementia to maintain their ADLs.

Catering To The Majority: Fashion’S Trial-And-Error Process To Make Style Accessible For All Sizes, Tiffany A. Del Valle

Capstones

Following the COVID-19 pandemic, two out of every three U.S. women are considered plus-size, or a size 14 and above. As the plus-size fashion market continues to grow and is expected to be worth $500 billion by 2033, finding extended sizes continues to be a barrier. While the fight for size-inclusive fashion has shown some progress in recent years, some brands have decided to scale back their plus-size offerings, while others have continued to limit their size ranges due to a multitude of reasons including production costs with a delayed return on investment, marketing and limited commitment to serving the …

December 13, 2024 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Journey To Baby-Friendly: Standardizing Patient Breastfeeding Education In The Postpartum Microsystem, Emily Korwin

Master's Projects and Capstones

Problem Low breastfeeding rates remain a global challenge and a cause of adverse infant health outcomes despite the benefits of exclusive breastfeeding. In response, UNICEF and the WHO developed the Baby-Friendly Hospital Initiative (BFHI) to promote, protect, and support breastfeeding for infant growth and development. Context Hospital A is a mid-size hospital in Northern California. It has 24 labor, 13 antepartum, and 33 postpartum beds and serves a diverse population of patients. Intervention After a literature review, microsystem assessment, stakeholder survey, and root cause analysis, a standardized infant feeding nurse patient education checklist was developed and aligned with Baby-Friendly teaching …

Data Privacy Protection For Zero-Permission Sensors In Iot Systems, Xinyi Liu

Theses

The Internet of Things (IoT) has revolutionized various domains through real-time decision-making and automation, with sensors serving as foundational components. Zero-permission sensors, such as accelerometers and gyroscopes, are widely used in most IoT systems, enabling unrestricted data access without permission. Despite being traditionally perceived as low-sensitivity, recent studies have shown that these sensors can be exploited to infer sensitive personal information, raising serious privacy concerns. Local Differential Privacy (LDP) is a rigorous technique for numerical data privacy protection even when the data collector, such as an IoT service provider, is untrusted. LDP ensures privacy by adding noise to sensor readings …

Applications Of Phosphorus Geochemistry To Utah Lake, Jacob Barry Taggart

Theses and Dissertations

This compilation of studies provides an examination of phosphorus dynamics in the suspended solids, water column, and lakebed sediments of Utah Lake, a large, shallow, and phosphorus-rich water body. The first study introduces a novel phosphorus microfractionation (P-MF) method designed for small samples of suspended solids and sediments. This method reveals that suspended solids in Utah Lake can have a significantly higher phosphorus content across most fractions compared to lakebed sediments, highlighting the importance of considering suspended solids in nutrient management strategies. The second study analyzes historical phosphorus mass and concentrations, demonstrating that water column phosphorus levels have remained stable …

Faculty And Staff Pay Satisfaction And The Impact On Organizational Commitment And Retention, Jennifer Hennings

Dissertations

This mixed-method study explored the relationships between pay satisfaction, organizational commitment, retention, and seniority among faculty and staff at a private, four-year institution in the Midwest. The research investigated how satisfaction with a compensation program influences organizational commitment and turnover intentions. The researcher used a quantitative method to study the impact of pay satisfaction on organizational commitment and turnover intention. Additionally, a quantitative method explored relationships between seniority and turnover intention. Findings revealed positive relationships between pay satisfaction and organizational commitment, along with pay satisfaction and turnover intention. Findings also revealed positive relationships between seniority, measured as years of service, …

Identifying Opportunities For Nature-Based Solutions With Geospatialized Life Cycle Assessments And Fine-Scale Socioecological Data, Gabriela Shirkey, Annick Anctil, Ranjeet John, Venkatesh Kolluru, Leah Mungai, Herve Kashongwe, Lauren T. Cooper, Ilke Celik, Joshua B. Fisher, Jiquan Chen

Civil and Environmental Engineering Faculty Publications and Presentations

As we increasingly understand the impact that land management intensification has on local and global climate, the call for nature-based solutions (NbS) in agroecosystems has expanded. Moreover, the pressing need to determine when and where NbS should be used raises challenges to socioecological data integration as we overcome spatiotemporal resolutions. Natural and working lands is an effort promoting NbS, particularly emissions reduction and carbon stock maintenance in forests. To overcome the spatiotemporal limitation, we integrated life cycle assessments (LCA), an ecological carbon stock model, and a land cover land use change model to synthesize rates of global warming potential (GWP) …