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2024

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Predicting The Organizational Citizenship Behaviors (Ocbs) Of Junior High School Teachers, Alfonso B. Astudillo Iii Dec 2024

Predicting The Organizational Citizenship Behaviors (Ocbs) Of Junior High School Teachers, Alfonso B. Astudillo Iii

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Organizational Citizenship Behavior (OCB) plays a crucial role in enhancing organizational effectiveness. This study examines the predictors of OCB among junior high school teachers in the local educational context. Utilizing a quantitative approach, stepwise multiple regression analysis was conducted to identify situational and dispositional variables that predict OCB. Seventeen predictors, including situational variables (type of school, organizational climate, and organizational justice) and dispositional attributes (sex, job satisfaction, work motivation, and personality traits), were analyzed. The findings reveal that while the initial hypothesis was not fully supported, specific variables significantly predicted OCB. Teacher job satisfaction emerged as a significant predictor of …


A Protection Or A Barrier? A Scoping Review Of Boundaries In Teacher-Student Relationships, Joseph Russell R. Santos Dec 2024

A Protection Or A Barrier? A Scoping Review Of Boundaries In Teacher-Student Relationships, Joseph Russell R. Santos

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Teacher-student relationships have differing potentialities in terms of importance and challenges, therefore implying the need for more effective navigation by placing healthy boundaries. However, the impact of this relationship and the boundary itself for both teachers and students need to be recognized to determine how they should be navigated. Doing so can give teachers and students healthier and more meaningful classroom experiences that align with the sustainable development goal of achieving optimal well-being and quality education. To examine the perceived importance and challenges of boundaries in teacher-student relationships, a scoping review was conducted. Eleven (11) out of the 29 studies …


Ilaw Ng Ibang Tahanan: Transnational Mothering Practices Of Overseas Filipina Domestic Workers During The Covid-19 Pandemic, Arvin John C. Ramirez Dec 2024

Ilaw Ng Ibang Tahanan: Transnational Mothering Practices Of Overseas Filipina Domestic Workers During The Covid-19 Pandemic, Arvin John C. Ramirez

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Filipino mothers traditionally serve as primary caregivers and, at times, as the main breadwinners for their families. With limited opportunities in the Philippines, many seek employment abroad, leaving their children behind. Data from the Philippine Statistics Authority indicated that female Overseas Filipino Workers (OFWs) often engage in elementary jobs, including domestic work and caregiving. The COVID-19 pandemic added a challenge in fulfilling their maternal needs since health and safety have become everyone’s priority. This study investigates the transnational mothering practices of overseas Filipina domestic workers during the pandemic and how these practices differ from those before the health crisis. Through …


Self-Agency As A Strategy In Emergency Remote Learning Among Filipino Grade 10 Students, John Cris C. Tababa, Paul Andrei C. Apo, Golden Grace R. Gammaru, Audrey S. Manaay, Kathrin Anne N. Nadua, James Fhonzy Angelo S. Fontillo Dec 2024

Self-Agency As A Strategy In Emergency Remote Learning Among Filipino Grade 10 Students, John Cris C. Tababa, Paul Andrei C. Apo, Golden Grace R. Gammaru, Audrey S. Manaay, Kathrin Anne N. Nadua, James Fhonzy Angelo S. Fontillo

Sinaya: A Philippine Journal for Senior High School Teachers and Students

The Coronavirus disease 2019 pandemic significantly influences students' educational attainment as they actively find and rationalize knowledge obtained from emergency remote learning. As a response, the agency or the ability to regulate one’s learning provides the students with the ability to believe in themselves. Still, it also necessitates the deliberate consideration to create a plan of action and modify it as required to achieve one's objectives. This study obtained knowledge from emergency remote learning (ERL) experiences of Filipino Grade 10 Students in their Social Studies class. The researchers employed a phenomenological approach to understand the self-agency practices of Grade 10 …


Citation Practices Of Contrasting Cultures In Q1 Journal Articles, April Rose C. Gonzales Dec 2024

Citation Practices Of Contrasting Cultures In Q1 Journal Articles, April Rose C. Gonzales

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Citation is a distinguishing feature in research writing that every researcher must include to ensure credible ethical research. Citing sources is necessary as it provides credit to the original author, refers to previous findings, sets credibility, and enables sustainability of the topic. However, studies least consider culture as an element that influences citation beliefs and practices. Most literature holds a lack of language proficiency as the culprit for poor citation skills. Drawing from Hofstede's Cultural Dimension theory (2011) and Lewis’ (2006) Cultural Behaviour in Relation to Writing, this study explores the influence of culture on citation practices with the hope …


Exploring Student Engagement In A Blended And Gamified Statistics And Probability: Designed With Learning Styles And Player Types, Reymund R. Gonowon Dec 2024

Exploring Student Engagement In A Blended And Gamified Statistics And Probability: Designed With Learning Styles And Player Types, Reymund R. Gonowon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

Educators are called to contribute towards achieving SDG 4: Quality Education. A major determinant in achieving this goal is providing learners with essential skills such as analyzing and interpreting data, making inferences, and driving evidence-based decisions which are the expected competencies in Statistics and Probability (STATPRO), one of the core subjects of the senior high school curriculum in the Philippines. To progress towards SDG 4, achieving the learning competencies of STATPRO is vital, however engaging students in a blended learning environment may be challenging. This study aims to explore the behavioral engagement of students in a gamified STATPRO class through …


The Environmental Rule Of Law's Transformative Power, Mariano H. Novelli Dec 2024

The Environmental Rule Of Law's Transformative Power, Mariano H. Novelli

Seattle Journal of Technology, Environmental, & Innovation Law

The Environmental Rule of Law is proposed as an ecocentric, transformative, and dynamic model. As a principle of governance, it implies values and standards that give rise to a new paradigm based on sustainable development, climate stability, and the circular economy, specifically focused on fundamental rights and obligations. Key factors of the Rule of Law revolution are the collective character of the environment, diffuse rights, the recognition of future generations and nature as legal subjects, and various principles with a strong protective purpose. The growing integration between human rights and the environment is another feature of the process, to be …


Defining The Social Licence Of Large Language Models In Healthcare, Robin L. Pierce, Jack Gallifant, Ashley Cordes, Amelia Fiske, Matilda Dorotic, Mataroria Lyndon, Shrey Jain, Joe Zhang, Judy Gichoya, Leo Anthony Celi Dec 2024

Defining The Social Licence Of Large Language Models In Healthcare, Robin L. Pierce, Jack Gallifant, Ashley Cordes, Amelia Fiske, Matilda Dorotic, Mataroria Lyndon, Shrey Jain, Joe Zhang, Judy Gichoya, Leo Anthony Celi

Seattle Journal of Technology, Environmental, & Innovation Law

As Large Language Models (LLMs) continue to grow and evolve, the ethical, social, and legal challenges they present, especially in terms of data use and sharing, come sharply into focus. Particularly in high-risk domains like healthcare, where the sensitivity of data is pronounced, and the ramifications of data leakages or misuse are profound. These licenses, envisioned to address the complexities introduced by LLMs, still grapple with barriers that hinder their full potential: notably, the absence of authoritative regulatory bodies, ambiguities in defining what constitutes 'sufficient public benefit', issues of data sovereignty, and dilemmas surrounding responsibility and liability. Herein, we delve …


Integrating Traditional And Western Healing Practices For American Indian Patients, Victoria Blacksmith Dec 2024

Integrating Traditional And Western Healing Practices For American Indian Patients, Victoria Blacksmith

Walden Dissertations and Doctoral Studies

The American Indian/Alaska Native (AI/AN) community experiences disproportionally high rates of mental health disorders. Although research had examined the benefits of using traditional AI/AN health practices, little was known about how integrating traditional and Western treatment methods works. Using historical trauma theory and oppression theory, this qualitative study explored how AI/AN clinicians integrate traditional health practices into Western treatment methods when treating mental health disorders in AI/AN patients. Data were collected through semistructured interviews with five clinicians. Data analysis via deductive coding revealed two main themes: lived experiences of AI/AN clinicians and integration strategies. Cultural knowledge was the most prominent …


Protocol For Culturing Patient-Derived Organoids Of Cervical Cancer, Rui Wang, Timothy Harris, Dalissa Negrón-Figueroa, David Lo, Allison Judge, D'Shaunique Walters, Bo Jiang, Lauren E Colbert Dec 2024

Protocol For Culturing Patient-Derived Organoids Of Cervical Cancer, Rui Wang, Timothy Harris, Dalissa Negrón-Figueroa, David Lo, Allison Judge, D'Shaunique Walters, Bo Jiang, Lauren E Colbert

Faculty, Staff and Student Publications

Herein, we present a protocol for culturing patient-derived organoids (PDOs) of cervical cancer that includes workflows for tumor biopsy/resection tissue and cytobrush-sampled cells. We describe steps for PDO culture initiation, including rinsing, gentle dissociation, Lymphoprep separation, and cell assessment, as well as seeding cells from surgical and cytobrush tissue digestion. We then provide guidance on PDO maintenance and passage and techniques for producing conditioned medium. Overall, this protocol serves as a valuable guide for establishing and maintaining cervical cancer PDOs. For complete details on the use and execution of this protocol, please refer to Colbert et al.


Micro: Bit A Tool For Learning And Innovation In The Digital Economy, Jarupa Kitcharoenpanya, Pongprapan Pongsophon, Ekgapoom Jantarakantee Dec 2024

Micro: Bit A Tool For Learning And Innovation In The Digital Economy, Jarupa Kitcharoenpanya, Pongprapan Pongsophon, Ekgapoom Jantarakantee

Journal of Education Studies

Micro: bit, a compact computing device, has become a vital tool for learning and innovation in the digital economy era, where economic systems are driven by digital technologies, including the use of the internet.  This academic article elucidates the diverse role of the Micro: bit in education and the cultivation of essential skills for students in the context of the rapidly advancing digital landscape. The Micro: bit is utilized as a foundation for teaching coding, basic programming, and developing computational skills for students due to its user-friendly nature, compact design, and affordability. This device facilitates exploration of the technology world …


Effects Of Active Learning In Physics Experiments On Academic Achievement, Attitudes And Concepts Among Grade-11 Students, Kittikhun Seawsakul Dec 2024

Effects Of Active Learning In Physics Experiments On Academic Achievement, Attitudes And Concepts Among Grade-11 Students, Kittikhun Seawsakul

Journal of Education Studies

One of the problems in learning physics is students’ attitudes. Most students think that physics is difficult to learn and to understand. This causes students' motivation and attitudes of curiosity towards the physics subject to decrease. The objectives of this work were to investigate students' attitudes towards physics and physics concepts, as well as to compare the academic achievement of the sample group before and after studying the lessons based on active learning through physics experiments. The sample group in this study consisted of 31 Grade 11 students, and data collection was conducted over the course of one semester. Data …


Graduate Competencies Under The Thai Qualifications Framework For Higher Education In Educational Administration, Sumet Ngamkanok Dec 2024

Graduate Competencies Under The Thai Qualifications Framework For Higher Education In Educational Administration, Sumet Ngamkanok

Journal of Education Studies

This research aimed to 1) study graduate competencies under the Thai Qualifications Framework for higher education in educational administration; 2) develop indicators for developing graduate competency for higher education in educational administration, 3) create a competency development manual for graduates under the Thai qualifications framework for higher education in educational administration. Research instruments included a semi-structured interview form for collecting data and experts interview conclusions to develop indicators and create the questionnaire for evaluation and focus group. There were three stages of the research procedures: 1) studying competency components of graduates under the Thai Qualifications Framework in educational administration; 2) …


The Needs For Developing High-Efficiency Learning Management In The Digital Era, Kanchit Pimjai, Duangkamol Traiwichitkhun Dec 2024

The Needs For Developing High-Efficiency Learning Management In The Digital Era, Kanchit Pimjai, Duangkamol Traiwichitkhun

Journal of Education Studies

This research aims to 1) study the conceptual framework for high-efficiency learning management in the digital era, and 2) investigate the needs for developing high-efficiency learning management in the digital era. The study employs a mixed-methods research design divided into two phases. Phase 1 involves qualitative research to address the conceptual framework for high-efficiency learning management in the digital era, with data collected from four selected experts using purposive sampling. The research tool was an interview guide, and the qualitative data was analyzed through content analysis, categorization, and summarization of findings. Phase 2 involves quantitative research to address the needs …


A Study Of The Impact Of Covid-19 On Developmental Decline And Learning Loss In Young Children And Recovery Guidelines, Wilailak Langka, Phornchulee Lungka, Narisara Peungposop, Suppawan Satjapiboon Dec 2024

A Study Of The Impact Of Covid-19 On Developmental Decline And Learning Loss In Young Children And Recovery Guidelines, Wilailak Langka, Phornchulee Lungka, Narisara Peungposop, Suppawan Satjapiboon

Journal of Education Studies

The COVID-19 pandemic significantly affected the educational system, particularly in young children education. There are guidelines for providing young children education during the COVID-19 pandemic, however, they are still broad and unclear in practice. This research aims to 1) study the impacts of the COVID-19 situation on early childhood children's developmental and learning regression, 2) analyze causal factors that influence teachers’ readiness to organize learning experiences, and 3) examine guidelines to recover the development of early childhood children. Qualitative data were collected via interviews with 50 participants, consisting of administrators and preschool teachers, while quantitative data were gathered using a …


Problems And Anxiety Management Of Piano Performance Contestants, Apichai Limtaveekiettikul, Narongchai Pidokrajt Dec 2024

Problems And Anxiety Management Of Piano Performance Contestants, Apichai Limtaveekiettikul, Narongchai Pidokrajt

Journal of Education Studies

Self-regulated anxiety among piano performance contestants is of utmost importance, especially for amateur pianists who lack experiences but still have to endure both internal and external pressure. Eliminating the underlying causes of issues that affect physical health, professional achievements, and lifestyles is crucial. Therefore, learning how to manage anxiety effectively is crucial. This article aims to offer self-management strategies for coping with anxiety during piano performances, particularly for new competitors or those who struggle with anxiety during the show. 1) creating imaginary situations in their minds that could serve as a bridge to reality 2) Planning and preparing in a …


Board Of Officers - Vol. 55, No. 2 2024 Dec 2024

Board Of Officers - Vol. 55, No. 2 2024

Seton Hall Law Review

No abstract provided.


Leave The Kids Alone: The Constitutional Battleground Of Gender-Affirming Health Care Bans For Transgender Youth, Tyler Callagy Dec 2024

Leave The Kids Alone: The Constitutional Battleground Of Gender-Affirming Health Care Bans For Transgender Youth, Tyler Callagy

Seton Hall Law Review

No abstract provided.


Electric Utility Industry Safety Plan Filing And Accident Reporting Impact On The Number Of Accidents, Rishi Singh Dec 2024

Electric Utility Industry Safety Plan Filing And Accident Reporting Impact On The Number Of Accidents, Rishi Singh

Walden Dissertations and Doctoral Studies

Safety is of paramount importance in the electric utility industry. Construction is the basis of electric work and is one of the most dangerous industries, with a high rate of accidents and fatalities. The purpose of this quantitative correlational study was to examine the relationship between the organizational leaders’ decision to file safety plans and accident reporting to the Occupational Safety and Health Administration or utility commissions on the number of accidents in the electric utility industry. The decision-making theory provided the study’s foundation. The study used secondary data from 2019 to 2023 for electric utility companies from California. Published …


From Policymaking To Legislation, The Need For A Secular Turn In Bioethics Discourse To Uphold, As A Function Of The Greater Good, Policy For Legislation Of Medically Aided Dying In The United States Of America, Scott Dyer Dec 2024

From Policymaking To Legislation, The Need For A Secular Turn In Bioethics Discourse To Uphold, As A Function Of The Greater Good, Policy For Legislation Of Medically Aided Dying In The United States Of America, Scott Dyer

Electronic Theses and Dissertations

A person’s right to self-determination is a central aspect of living in a democratic nation. Similarly, decisions regarding medical care are generally left up to the patient to determine what treatment is or is not appropriate. The same should apply to end-of-life care as well, especially when a patient desires to hasten his or her death via medically aided dying. However, due to the illegality of medically assisted dying in most of the United States, the right to a self-determined death is not possible for the majority of American citizens. One of the main reasons for this is due to …


Governing The Paddies: Emotions, Dispossession, And Gendered Struggles For Resource Access In Rice Farming In Tolima, Colombia, Akemi Inamoto Dec 2024

Governing The Paddies: Emotions, Dispossession, And Gendered Struggles For Resource Access In Rice Farming In Tolima, Colombia, Akemi Inamoto

Dissertations - ALL

Colombia produces nearly one million tons of irrigated rice annually, almost exclusively for domestic consumption, with 72% of this production driven by smallholder farmers. In the department of Tolima, rice farming plays a significant role in both the local political economy and the agrarian landscape. This dissertation engages with feminist political ecology, critical agrarian studies, and debates on agrarian transformation to examine the everyday manifestations of dispossession that shape the lives of smallholder farmers and farmworkers in rural Tolima. I focus on how gender and class dynamics structure access to resources and opportunities, with special attention to the experiences and …


Elementary Science Instruction: A Document Analysis Of Teacher Messaging Across Two Sets Of Curriculum Materials, Jessica Mary Whisher-Hehl Dec 2024

Elementary Science Instruction: A Document Analysis Of Teacher Messaging Across Two Sets Of Curriculum Materials, Jessica Mary Whisher-Hehl

Dissertations - ALL

Elementary teachers are tasked with teaching multiple subjects within an instructional day. One mechanism to support this task is through strong curriculum materials, which lay out a course of instruction aligned with instructional standards. This is helpful when teachers are trying to teach to a new set of standards, such as the Next Generation Science Standards, which require a significant shift in instructional strategies. In cases such as this, educative features embedded in the curriculum materials can assist teachers in making the required shifts in instruction. However, sometimes the instructional time required by curriculum materials, especially in elementary science, is …


Cognitive Load Classification From Functional Near-Infrared Spectroscopy Data, Jiyang Wang Dec 2024

Cognitive Load Classification From Functional Near-Infrared Spectroscopy Data, Jiyang Wang

Dissertations - ALL

Predicting cognitive workload using physiological sensors, such as functional near-infrared spectroscopy (fNIRS), has gained significant attention in recent years. However, many existing methods are limited by small datasets and narrow brain channel coverage, restricting their generalizability across participants, tasks, and sessions. In this thesis, we introduce two innovative approaches aimed at overcoming these limitations: a CNN-BiGRU model with self-supervised label augmentation (SLA) and a block-wise domain adaptation method (BWise-DA). Our CNN-BiGRU-SLA model, grounded in cognitive load theory, leverages attention mechanisms and multi-label classification to predict working memory load (WML) and visual processing load (VPL) across multiple participants and sessions. Using …


Estranged Bodies, Race, And Sectarianism: An Historical Bioarchaeology Of Ottoman And French Beirut, Tony John Chamoun Dec 2024

Estranged Bodies, Race, And Sectarianism: An Historical Bioarchaeology Of Ottoman And French Beirut, Tony John Chamoun

Dissertations - ALL

Modern imperial formations involve a violent reconfiguring of difference that is inseparable from the everyday. Modern-world archaeology as a project that studies interlocking vicissitudes of modernity globally has done much to elucidate the varied social orders and politics of knowledge through which such reshuffling occurs. Yet largely missing from this conversation is the bioarchaeology of the Middle East and North Africa region; as such, the very bodies who shaped and were shaped by modern conditions in a major world circuit are also missing. To advance a more global and grounded investigation of modernity, I turn to the port city of …


In The Wholeness Of Time, Ethan Brue Dec 2024

In The Wholeness Of Time, Ethan Brue

Faculty Work Comprehensive List

"In a world that urges us to consume time, how do we change our approach, moving from simply passing time to filling it with holiness and patience that reflects God's character?"

Posting about ­­­­­­­­a Christian perspective on time from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

In the Wholeness of Time


Mathematical Multi-Compartment Modeling Of Chronic Lymphocytic Leukemia Cell Kinetics Under Ibrutinib, Melanie Schulz, Sanne Bleser, Manouk Groels, Dragan Bošnački, Jan A Burger, Nicholas Chiorazzi, Carsten Marr Dec 2024

Mathematical Multi-Compartment Modeling Of Chronic Lymphocytic Leukemia Cell Kinetics Under Ibrutinib, Melanie Schulz, Sanne Bleser, Manouk Groels, Dragan Bošnački, Jan A Burger, Nicholas Chiorazzi, Carsten Marr

Faculty, Staff and Student Publications

The Bruton tyrosine kinase inhibitor ibrutinib is an effective treatment for patients with chronic lymphocytic leukemia (CLL). While it rapidly reduces lymph node and spleen size, it initially increases the number of lymphocytes in the blood due to cell redistribution. A previously published mathematical model described and quantified those cell kinetics. Here, we propose an alternative mechanistic model that outperforms the previous model in 26 of 29 patients. Our model introduces constant subcompartments for healthy lymphocytes and benign tissue and treats spleen and lymph nodes as separate compartments. This three-compartment model (comprising blood, spleen, and lymph nodes) performed significantly better …


Results Of The Simultaneous Combination Of Ponatinib And Blinatumomab In Philadelphia Chromosome-Positive All, Hagop Kantarjian, Nicholas J Short, Fadi G Haddad, Nitin Jain, Xuelin Huang, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Tapan M Kadia, Naval Daver, Kelly Chien, Yesid Alvarado, Guillermo Garcia-Manero, Ghayas C Issa, Rebecca Garris, Cedric Nasnas, Lewis Nasr, Farhad Ravandi, Elias Jabbour Dec 2024

Results Of The Simultaneous Combination Of Ponatinib And Blinatumomab In Philadelphia Chromosome-Positive All, Hagop Kantarjian, Nicholas J Short, Fadi G Haddad, Nitin Jain, Xuelin Huang, Guillermo Montalban-Bravo, Rashmi Kanagal-Shamanna, Tapan M Kadia, Naval Daver, Kelly Chien, Yesid Alvarado, Guillermo Garcia-Manero, Ghayas C Issa, Rebecca Garris, Cedric Nasnas, Lewis Nasr, Farhad Ravandi, Elias Jabbour

Faculty, Staff and Student Publications

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.In this analysis, we update our experience with the chemotherapy-free regimen of blinatumomab and ponatinib in 60 patients with newly diagnosed Philadelphia chromosome (Ph)-positive ALL. At a median follow-up of 24 months, the complete molecular response rate …


Survival Analysis Of Clear Cell Renal Cell Carcinoma Based On Radiomics And Deep Learning Features From Ct Images, Zhennan Lu, Sijia Wu, Dan Ni, Meng Zhou, Tao Wang, Xiaobo Zhou, Liyu Huang, Yu Yan Dec 2024

Survival Analysis Of Clear Cell Renal Cell Carcinoma Based On Radiomics And Deep Learning Features From Ct Images, Zhennan Lu, Sijia Wu, Dan Ni, Meng Zhou, Tao Wang, Xiaobo Zhou, Liyu Huang, Yu Yan

Faculty, Staff and Student Publications

Purpose: To create a nomogram for accurate prognosis of patients with clear cell renal cell carcinoma (ccRCC) based on computed tomography images.

Methods: Eight hundred twenty-two ccRCC patients with contrast-enhanced computed tomography images involved in this study were collected. A rectangular region of interest surrounding the tumor was used to extract quantitative radiomics and deep-learning features, which were filtered by Cox proportional hazard regression model and least absolute shrinkage and selection operator. Then the selected features formed a fusion signature, which was assessed by Cox proportional hazard regression model method, Kaplan-Meier analysis, receiver operating characteristic curves, and concordance index (C-index) …


Formulation And Characterization Of Biologics – From Sirna To Monoclonal Antibodies, Chinmay M. Jogdeo Dec 2024

Formulation And Characterization Of Biologics – From Sirna To Monoclonal Antibodies, Chinmay M. Jogdeo

Theses & Dissertations

Biologics are a rapidly growing class of therapeutics, encompassing a wide range of modalities, with gene therapy products and monoclonal antibodies (mAbs) constituting the majority. Proper formulation and characterization of these complex therapeutics is crucial to ensure their safety and therapeutic efficacy.

This dissertation focuses on two main areas: the development of a novel renal-targeted siRNA delivery system and the assessment of structural and conformational stability of mAbs in a simulated subcutaneous (SC) environment.

The first part of this dissertation presents the synthesis and characterization of a novel renal-targeted polymer for selective siRNA delivery to injured kidneys. Inulin was modified …


Investigating Catalytic Conversion Of Lignin To Valuable Products, Jialiang Zhang Dec 2024

Investigating Catalytic Conversion Of Lignin To Valuable Products, Jialiang Zhang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Lignin is a complex, random, and heterogeneous biopolymer in lignocellulosic biomass. It has significant potential for conversion into valuable chemicals and fuels. However, its natural recalcitrant structure has made selective depolymerization challenging. This dissertation presents a detailed investigation into the mechanisms of lignin disassembly and structural evolution under various catalytic and solvent conditions. The research spans three key studies. In Chapter 2, operando magic-angle spinning (MAS) solid-state nuclear magnetic resonance (NMR) spectroscopy was employed to study reaction pathways and kinetics of lignin model polymers during catalytic hydrogenolysis. We used a Ni-Al2O3 catalyst in methanol under high temperature and pressure, and …