Digital Commons Network^™

Age-Stratified Mosaic Of Neuropathies: A Comprehensive Analysis Of The Prevalence And Patterns In Different Age Groups, Sana Ghous, Anjlee Shankar, Abdul Qadir Baloch, Dipanty Khastoori, Tahira Maqsood, Alam Ibrahim Siddiqui

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT

Background and Objective:

Neuropathies pose significant challenges in diagnosis and management due to their heterogeneous etiologies, varied clinical presentations, and differential prevalence across age groups. The objective of this study was to analyze the distribution of neuropathies among patients in various age brackets, highlighting prevalent neuropathic types and their clinical implications.

Methods:

From September 18, 2018 to September 17, 2019, 405 patients from Neurology Ward of Chandka Medical College Hospital in Larkana were included in this retrospective cross-sectional comprehensive analysis. Nerve conduction studies (NCS) of these patients were conducted in the electrophysiology department. The study cohort was stratified into …

Beyond The Mosquito Sting: Guillain-Barre Syndrome Following Malarial Seasonal Surge, Sana Ghous, Alam Ibrahim Siddiqui, Abdul Rahman Soomro, Abu Bakar Shaikh, Sajjad Hussain Jalbani, Abdul Ghafoor Magsi

Pakistan Journal of Neurological Sciences (PJNS)

ABSTRACT

Background and objective:

Malaria, a prevalent disease most commonly caused by Plasmodium vivax and falciparum, frequently leads to intricate neurological complications. The objective of this study was to study Guillain-Barre syndrome as a prevalent neurological manifestation of malaria.

Methods:

A cross-sectional observational study was undertaken at Neurology Department of Chandka Medical College Hospital in Larkana, from April 2023 to September 2023 during the seasonal peak of malaria. The study included 20 patients who met the specified criteria. SPSS version 23.0 was used for data analysis.

Results:

Among the 20 patients who developed Guillain-Barre Syndrome following malaria infection, 18 exhibited …

Nursing News & Views - March 2024, Joanne Miller Rn

Nursing Newsletters

No abstract provided.

An Umbrella Review Of Self-Management Interventions For Health Conditions With Symptom Overlap With Traumatic Brain Injury, Angelle Sander, Monique Pappadis, Tamara Bushnik, Nancy Chiaravalloti, Simon Driver, Robin Hanks, Kirk Lercher, Dawn Neumann, Amanda Rabinowitz, Ronald T Seel, Erica Weber, Rick Ralston, John Corrigan, Kurt Kroenke, Flora Hammond

Department of Rehabilitation Medicine Faculty Papers

OBJECTIVE: To synthesize evidence for the effectiveness of self-management interventions for chronic health conditions that have symptom overlap with traumatic brain injury (TBI) in order to extract recommendations for self-management intervention in persons with TBI.

DESIGN: An umbrella review of existing systematic reviews and/or meta-analyses of randomized controlled trials or nonrandomized studies targeting self-management of chronic conditions and specific outcomes relevant to persons with TBI.

METHOD: A comprehensive literature search of 5 databases was conducted using PRISMA guidelines. Two independent reviewers conducted screening and data extraction using the Covidence web-based review platform. Quality assessment was conducted using criteria adapted from …

Effects Of Storage Conditions On Chemistry And Technological Properties Of Different Cultivars Of Chickpea, Shirin Kazemzadeh Pournaki, Atanu Biswas, Clifford Hall

Dairy Science and Food Science Faculty Publications: 2022 to Present

The impact of storage conditions, such as 40 °C, high humidities (55% and 65%), and storage (360 days), on the nutritional value, pasting, and functional properties, color differences, and quality of protein and starch in five Chickpea (Cicer arietinum) cultivars (Crown, Royal, Sierra, Orion, and Frontier) was determined. The Sierra cultivar had the highest initial moisture content (MC, 7.7 ± 0.01%), and MC increased over time for all samples stored at 55% and 65% RH and 21 °C. Protein (PC), total starch (TSC), and fat (FC) contents changed in all cultivars during storage. Under the same storage conditions …

Real Food Challenge And Climate Impact Assessment: A Food System Analysis At Santa Clara University, 2022-2023, Abby Crowley, Isabelle Solórzano

Sustainable Food Systems Fellowship

Two undergraduate students at Santa Clara University were hired to work as Food Systems Fellows from July 2023 to January, 2024. This position was co-sponsored by the Center for Sustainability and the Auxiliary Services division. The goal of this work was to explore the Santa Clara University food system’s impact on the environment from both an ecological and a social perspective and identify opportunities for improvement.

The Fellows utilized standards and core values from The Real Food Challenge, a national non-profit dedicated to leveraging the power of colleges and universities to increase equity and sustainability in food systems. The Real …

Cross-Sectional Association Between Blood Cholesterol And Calcium Levels In Genetically Diverse Strains Of Mice., Cody M Cousineau, Kaelin Loftus, Gary Churchill, Dave Bridges

Faculty Research 2024

Genetically diverse outbred mice allow for the study of genetic variation in the context of high dietary and environmental control. Using a machine learning approach, we investigated clinical and morphometric factors that associate with serum cholesterol levels in 840 genetically unique Diversity Outbred mice of both sexes (n = 417 male and 423 female), and on both a control chow (% kcals in diet: protein 22%, carbohydrate 62%, fat 16%, no cholesterol) and high fat high sucrose (% kcals in diet: protein 15%, carbohydrate 41%, fat 45%, 0.05% cholesterol). We find expected elevations of cholesterol in male mice, as well …

The Immunopathological Landscape Of Human Pre-Tcrα Deficiency: From Rare To Common Variants., Marie Materna, Ottavia M Delmonte, Marita Bosticardo, Mana Momenilandi, Peyton E Conrey, Bénédicte Charmeteau-De Muylder, Clotilde Bravetti, Rebecca Bellworthy, Axel Cederholm, Frederik Staels, Christian A Ganoza, Samuel Darko, Samir Sayed, Corentin Le Floc'h, Masato Ogishi, Darawan Rinchai, Andrea Guenoun, Alexandre Bolze, Taushif Khan, Adrian Gervais, Renate Krüger, Mirjam Völler, Boaz Palterer, Mahnaz Sadeghi-Shabestari, Anne Langlois De Septenville, Chaim A Schramm, Sanjana Shah, John J Tello-Cajiao, Francesca Pala, Kayla Amini, Jose S Campos, Noemia Santana Lima, Daniel Eriksson, Romain Lévy, Yoann Seeleuthner, Soma Jyonouchi, Manar Ata, Fatima Al Ali, Anna Stittrich, Caroline Deswarte, Anaïs Pereira, Jérôme Mégret, Tom Le Voyer, Paul Bastard, Laureline Berteloot, Michaël Dussiot, Natasha Vladikine, Paula P Cardenas, Emmanuelle Jouanguy, Mashael Alqahtani, Amal Hasan, Thangavel Alphonse Thanaraj, Jérémie Rosain, Fahd Al Qureshah, Vito Sabato, Marie Alexandra Alyanakian, Marianne Leruez-Ville, Flore Rozenberg, Elie Haddad, Jose R Regueiro, Maria L Toribio, Judith R Kelsen, Mansoor Salehi, Shahram Nasiri, Mehdi Torabizadeh, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Nasimeh Vatandoost, Hossein Moravej, Seyed Mohammad Akrami, Mohsen Mazloomrezaei, Aurélie Cobat, Isabelle Meyts, Etsushi Toyofuku, Madoka Nishimura, Kunihiko Moriya, Tomoyuki Mizukami, Kohsuke Imai, Laurent Abel, Bernard Malissen, Fahd Al-Mulla, Fowzan Sami Alkuraya, Nima Parvaneh, Horst Von Bernuth, Christian Beetz, Frédéric Davi, Daniel C Douek, Rémi Cheynier, David Langlais, Nils Landegren, Nico Marr, Tomohiro Morio, Mohammad Shahrooei, Rik Schrijvers, Sarah E Henrickson, Hervé Luche, Luigi D Notarangelo, Jean-Laurent Casanova, Vivien Béziat

Faculty Research 2024

We describe humans with rare biallelic loss-of-function PTCRA variants impairing pre–a T cell receptor (pre-TCRa) expression. Low circulating naive ab T cell counts at birth persisted over time, with normal memory ab and high gd T cell counts. Their TCRa repertoire was biased, which suggests that noncanonical thymic differentiation pathways can rescue ab T cell development. Only a minority of these individuals were sick, with infection, lymphoproliferation, and/or autoimmunity. We also report that 1 in 4000 individuals from the Middle East and South Asia are homozygous for a common hypomorphic PTCRA variant. They had normal circulating naive ab T cell …

Folate Deficiency And/Or The Genetic Variant Mthfr(677c >T) Can Drive Hepatic Fibrosis Or Steatosis In Mice, In A Sex-Specific Manner, Daniel Leclerc, Karen E Christensen, Alaina M Reagan, Vafa Keser, Yan Luan, Olga V Malysheva, Brandi Wasek, Teodoro Bottiglieri, Marie A Caudill, Gareth R Howell, Rima Rozen

Faculty Research 2024

Scope: Disturbances in one-carbon metabolism contribute to nonalcoholic fatty liver disease (NAFLD) which encompasses steatosis, steatohepatitis, fibrosis, and cirrhosis. The goal is to examine impact of folate deficiency and the Mthfr677C >T variant on NAFLD. Methods and results: This study uses the new Mthfr677C >T mouse model for the human MTHFR677C >T variant. Mthfr677CC and Mthfr677TT mice were fed control diet (CD) or folate-deficient (FD) diets for 4 months. FD and Mthfr677TT alter choline/methyl metabolites in liver and/or plasma (decreased S-adenosylmethionine (SAM):S-adenosylhomocysteine (SAH) ratio, methyltetrahydrofolate, and betaine; increased homocysteine [Hcy]). FD, with contribution from Mthfr677TT, provokes fibrosis in males. Studies …

Adolescents With Eating Disorders Due To Bullying, Avery Page

South Carolina Association for Middle Level Education Journal

Bullying is a strong predictor of eating disorders. Adolescent girls are more susceptible to developing eating disorders due to social media, developmental changes, and societal pressure for unattainable perfection. Adolescent advocates have an important role in addressing this issue and providing support for students.

From Precedent To Policy: The Effects Of Dobbs On Detained Immigrant Youth, Ciera Phung-Marion

Washington Law Review

In June 2022, the United States Supreme Court released the historic decision Dobbs v. Jackson Women’s Health Organization, holding that the U.S. Constitution does not protect an individual’s right to an abortion. Dobbs overturned many cases, including J.D. v. Azar, which previously protected abortion rights for unaccompanied migrant youth in federal detention facilities. Post-Dobbs, the Office of Refugee Resettlement (ORR)—the agency responsible for caring for detained immigrant children—still protects abortion rights as part of its own internal policy. Without judicial precedent, however, this policy lacks the stability to truly protect the rights of the children in its …

Hurt, Hungry, And Handcuffed: How The Prison System Fails Pregnant Women And Their Newborns, Sarah B. Bondar

Marquette Benefits and Social Welfare Law Review

Over 200,000 women are incarcerated in the United States’ federal and state correctional institutions on any given day. In fact, more women are incarcerated now than ever before, and those rates of incarceration continue to grow at an exponential rate. Despite this large increase in the number of incarcerated women, jail policies, health-care protocols, and important interventions continue to focus primarily on incarcerated men and fail to consider the gender-specific needs of the increasing population of incarcerated females.

This comment discusses ways the United States prison system fails the pregnant women in their care. It discusses four main points including: …

Maine Career Exploration: Interim Evaluation Report, Sydney Brown, Julia Bergeron-Smith Mppm, Msw, Sarah Goan, Madison Burke, Becky Wurwarg

Publications

The Maine Career Exploration (MCE) Program is a two-year pilot initiative designed to connect young people with Maine’s economy through hands-on, age-appropriate career exploration experiences. Launched in 2022 with funding from Governor Janet Mills’ Jobs and Recovery Plan, the program seeks to provide meaningful paid work experiences, expand career exploration programming in schools and communities, and create sustainable infrastructure to support long-term career readiness opportunities across the state. Managed by the Maine Department of Economic and Community Development, the initiative invests in three main areas: the Maine Children’s Cabinet Career Exploration Pilot Project, the Maine Department of Education’s Extended Learning …

Assessing The Influence Of Covid-19 Lockdown Measures On Cognition And Behavior In School Age Children In Arba Minch Health And Demographic Surveillance Site, Southern Ethiopia: A Cross-Sectional Study, Befikadu Tariku Gutema, Eshetu Zerihun Tariku, Zeleke Aschalew Melketsedik, Bruno Levecke, Stefaan De Henauw, Amina Abubakar, Souheila Abbeddou

Institute for Human Development, East Africa

Ethiopian schools were closed for nearly 40 weeks as a measure to control the COVID-19 pandemic. The objective of the study was to evaluate the role of COVID-19 pandemic’s restrictive measures on cognition and behavioral difficulties of schoolchildren in Arba Minch Health and Demographic Surveillance Site. Two cross-sectional surveys were conducted in November 2019 (pre-COVID-19-lockdown) and November 2020 (post-COVID-19 lockdown). Data were collected both at the school and homes of the children. Cognitive development of the children was assessed using digit span, Raven’s coloured progressive matrices (RCPM) and Visual search using cancellation task. Behavioral difficulties score of the children was …

It’S Dead! Can Postbiotics Really Help Performance And Recovery? A Systematic Review, Chad M. Kerksick, Jessica M. Moon, Ralf Jäger

Faculty Scholarship

In recent years, postbiotics have increased in popularity, but the potential relevancy of postbiotics for augmenting exercise performance, recovery, and health is underexplored. A systematic literature search of Google Scholar and PubMed databases was performed with the main objective being to identify and summarize the current body of scientific literature on postbiotic supplementation and outcomes related to exercise performance and recovery. Inclusion criteria for this systematic review consisted of peer-reviewed, randomized, double-blind, and placebo-controlled trials, with a population including healthy men or women >18 years of age. Studies required the incorporation of a postbiotic supplementation regimen and an outcome linked …

Milk Or Kefir, In Comparison To Water, Do Not Enhance Running Time-Trial Performance In Endurance Master Athletes, Kristen N. Gross, Patrick S. Harty, Joesi M. Krieger, Petey W. Mumford, Kyle L. Sunderland, Anthony M. Hagele, Chad Kerksick

Faculty Scholarship

This study compared flavored kefir (KFR) and flavored milk (MLK) as a recovery drink in endurance master athletes. Using a randomized, placebo-controlled, non-blinded crossover design, 11 males and females completed three testing visits whilst acutely ingesting either KFR, MLK, or water as a placebo (PLA). KFR supplementation occurred for 14 days before the KFR-testing day, followed by a 3-week washout period. Testing visits consisted of an exhausting-exercise (EE) bout, a 4-h rest period where additional carbohydrate feeding was provided, and a treadmill 5 km time trial (TT). The Gastrointestinal Symptom Rating Scale (GSRS) survey was assessed at four timepoints. Blood …

A Socio-Ecological Approach To A Community-Based Health Promotion Intervention On The U.S.-Mexico Border: Insights And Lessons Learned During The Covid-19 Pandemic, Yok-Fong Paat, Elizabeth Camacho, Sarah L. Ruiz, Diego Garcia Tovar, Guillermina Gina Núñez-Mchiri, Maria O. Duarte-Gardea, Guadalupe Corral, Sandra Oviedo Ramirez, Christine Markham, Luis R. Torres-Hostos

School of Social Work Faculty Publications

The Healthy Families Healthy Kids Initiative (HFHKI) is a community-based initiative developed based on the socio-ecological model to address preventive health care needs in El Paso County, Texas, one of the most economically and health-challenged border communities in the United States. HFHKI’s three main goals are to increase access to experiential learning and health education, service delivery, and sustainable systems/linkages of care. These were accomplished through seven critical activities. We present the rationale, background, setting, and conceptual framework for the initiative, followed by the methods used to develop and assess the success of the activities and results of our project …

Public–Private Partnerships In Strengthening Rural Food Supply Chains: A Financial And Operational Model For Federal Collaboration, Sarah Onyeche Usoro, Aminat Adebukola Amunigun

Student Publications

Rural food supply chains in the United States exhibit structural fragility, chronic underfunding, and limited integration with federal investment mechanisms. Cold storage capacity remains inadequate, aggregation infrastructure is sparse, and processing and last-mile distribution face persistent bottlenecks across much of rural America. These domestic conditions reflect a broader global pattern: the FAO estimates that approximately 733 million people faced hunger in 2023, with rural populations bearing a disproportionate share of that burden [1]. This paper addresses the domestic dimension of that challenge by synthesizing the existing literature on public–private partnerships (PPPs) in food systems infrastructure and proposing an original financial …

Claudin-1 As A Novel Target Gene Induced In Obesity And Associated To Inflammation, Fibrosis, And Cell Differentiation, Pablo Fernández-García, Siri D. Taxerås, Marjorie Reyes-Farias, Lorena González, Andrea Soria-Gondek, Silvia Pellitero, Jordi Tarascó, Pau Moreno, Lauro Sumoy, Jacqueline M. Stephens, Lindsey G. Yoo, María Galán, Adriana Izquierdo, Gema Medina-Gómez, Laura Herrero, Patricia Corrales, Francesc Villarroya, Rubén Cereijo, David Sánchez-Infantes

Division of Basic Science Faculty Publications

Objective: T lymphocytes from visceral and subcutaneous white adipose tissues (vWAT and sWAT, respectively) can have opposing roles in the systemic metabolic changes associated with obesity. However, few studies have focused on this subject. Claudin-1 (CLDN1) is a protein involved canonically in tight junctions and tissue paracellular permeability. We evaluated T-lymphocyte gene expression in vWAT and sWAT and in the whole adipose depots in human samples. Methods: A Clariom D-based transcriptomic analysis was performed on T lymphocytes magnetically separated from vWAT and sWAT from patients with obesity (Cohort 1; N = 11). Expression of candidate genes resulting from that analysis …

Exploring Successful Implementation Of Organizational Supports At The Worksite Environment: A Mixed Methods Approach, Renee A. Underwood, Ralph J. Wood, Alexandra D. Tomchek, Michael D. Celestin, Richard Culbertson, Stephen Phillippi, Stephanie T. Broyles

Population and Public Health Science Faculty Publications

While there is evidence that organizational supports may lead to better employee health, research on implementing such organizational supports is lacking. This research sought to understand organizational supports and implementation of those supports using an Explanatory Sequential Mixed Methods design approach. Employee survey responses (n = 202) were used to classify organizations into “high” and “low” categories for employee-reported health behavior improvement, agreement, and readiness for implementing change. For the qualitative phase of research (organization-level), semi-structured interviews were conducted with organization leads, and data were analyzed through constant comparative analysis procedure. Analyses sought to identify differences between “high” versus “low” …

Long Story Short, Hannah M. Varghese

Graphic Communication

Long Story Short and is a vintage up-cycling art brand. Our mission is to breathe new life into vintage pieces, crafting them into modern wearable art. As the name suggests, each creation tells a story while being revitalized for today’s fashion forward community.

Fast fashion and trend cycling has been a growing problem in today’s society. Things are going ‘in’ and ‘out’ quicker than they ever have. Trend cycling usually operates on a 20-year timeline. But, today’s sped up cycle encourages people to constantly over-consume in chase of the next cool thing. It’s unsustainable and an impossible chase. With a …

Influence Of Hesperidin On The Physico-Chemical, Microbiological And Sensory Characteristics Of Frozen Yogurt †, Roberto Cedillos, Ricardo S. Aleman, Ryan Page, Douglas W. Olson, Charles Boeneke, Witoon Prinyawiwatkul, Kayanush Aryana

Faculty Publications

Frozen yogurts contain yogurt culture bacteria, which might impart health benefits to their consumers. Global frozen yogurt market sales are expected to grow by 4.8% by 2028, which represents an important opportunity for the industry, consumers and researchers. Polyphenols are metabolites found in plants which have antioxidant and anti-inflammatory properties and might prevent chronic diseases such as cancer, diabetes and cardiovascular diseases. The objective of this study was to elucidate the effect of the polyphenol hesperidin on the physico-chemical, microbiological and sensory characteristics of frozen yogurts. Hesperidin was incorporated into frozen yogurt at three concentrations (125, 250 and 500 mg/90 …

Transformative Insights: Break Up With Salt (Buws) Program’S Short-Term Influence On Hypertension Risk Factors, Jean Pierre Enriquez, Helena Salgado, Christopher Kuetsinya, Li Hsiang Lin, Elizabeth Gollub

Faculty Publications

Break Up with Salt (BUWS) is a four-session community-based nutrition education program aimed at reducing key controllable hypertension risk factors. This pilot study utilized a pre-post survey design to assess short-term outcomes on food behaviors (including DASH diet eating patterns), physical activity, and overall well-being, in two groups of participants. The first “pilot” group (n = 25) completed a comprehensive, 16-item survey; the second “abbreviated” group (n = 27) completed a 5-item survey. The pilot group experienced improvements in whole grain (p = 0.04), sweetened beverage consumption, watching/reducing sodium (p = 0.04) and fat (p = 0.05) consumption, and time …

Seven-Year Prospective Study On Yearly Incidence Of Orbivirus Infection Of Captive White-Tailed Deer And Potential Culicoides Vectors, Michael Becker, Glen Gentry, Claudia Husseneder, Lane Foil

Faculty Publications

Bluetongue virus (BTV) and epizootic hemorrhagic disease virus (EHDV) are arthropod-borne viruses that are transmitted by biting midges in the genus Culicoides (Diptera: Ceratopogonidae) and can cause hemorrhagic disease in certain ruminants. The objectives of this study were to measure the incidence of BTV and EHDV infections in captive white-tailed deer herd as well as tissues and corresponding presence of Culicoides midges at a location near Clinton, LA. During a 7-yr study with yearly outbreaks of hemorrhagic disease in the deer herd, 15 species of Culicoides were captured using Centers for Disease Control (CDC) black light traps. Reverse transcriptase quantitative …

Sustainable Sweetpotato Production In The United States: Current Status, Challenges, And Opportunities, Justin George, Gadi V.P. Reddy, Phillip A. Wadl, William Rutter, Julianna Culbreath, Pierre W. Lau, Tahir Rashid, Matthew C. Allan, Suzanne D. Johaningsmeier, Amanda M. Nelson, Ming Li Wang, Augustine Gubba, Kai Shu Ling, Yan Meng, Daniel J. Collins, Sathish K. Ponniah, Prasanna H. Gowda

Faculty Publications

Sweetpotato (Ipomoea batatas L.) is an important staple crop cultivated in over 100 countries, and the storage roots and vines provide food for humans and livestock. Sweetpotato consumption and demand for its value-added products have increased significantly in the last two decades and have led to new cultivar development, expansion in acreage, and increased demand in the United States and its export markets. Despite the known nutritional components and other health benefits, further research is needed to characterize the genetic diversity and chemical composition related to their storage root qualities, essential in developing consumer-preferred cultivars that offer host plant resistance …

Effects Of Testosterone Enanthate On Aggression, Risk-Taking, Competition, Mood, And Other Cognitive Domains During 28 Days Of Severe Energy Deprivation, Harris R. Lieberman, John A. Caldwell, Oshin Vartanian, Owen T. Carmichael, J. Philip Karl, Claire E. Berryman, Kishore M. Gadde, Philip J. Niro, Melissa N. Harris, Jennifer C. Rood, Stefan M. Pasiakos

Clinical Research Faculty Publications

Rationale: Behavioral effects of testosterone depend on dose, acute versus sustained formulation, duration of administration, personality, genetics, and endogenous levels of testosterone. There are also considerable differences between effects of endogenous and exogenous testosterone. Objectives: This study was the secondary behavioral arm of a registered clinical trial designed to determine if testosterone protects against loss of lean body mass and lower-body muscle function induced by a severe energy deficit typical of sustained military operations. Methods: Behavioral effects of repeated doses of testosterone on healthy young men whose testosterone was reduced by severe energy deficit were examined. This was a double-blind, …

Predictors Of Racial Differences In Weight Loss: The Propel Trial, Robert L. Newton, Dachaun Zhang, William D. Johnson, Corby K. Martin, John W. Apolzan, Kara D. Denstel, Phillip J. Brantley, Terry C. Davis, Connie Arnold, Daniel F. Sarpong, Eboni G. Price-Haywood, Carl J. Lavie, Tina K. Thethi, Peter T. Katzmarzyk

Clinical Research Faculty Publications

Objective: Studies have consistently shown that African American individuals lose less weight in response to behavioral interventions, but the mechanisms leading to this result have been understudied. Methods: Data were derived from the PROmoting Successful Weight Loss in Primary CarE in Louisiana (PROPEL) study, which was a cluster-randomized, two-arm trial conducted in primary care clinics. In the PROPEL trial, African American individuals lost less weight compared with patients who belonged to other racial groups after 24 months. In the current study, counterfactual mediation analyses among 445 patients in the intervention arm of PROPEL were used to determine which variables mediated …

Exercise-Induced Changes In Central Adiposity During An Rct: Effect Of Exercise Dose And Associations With Compensation, James L. Dorling, John W. Apolzan, Neil M. Johannsen, Diana M. Thomas, Christoph Höchsmann, Daniel S. Hsia, Corby K. Martin

Clinical Research Faculty Publications

Context: Exercise can decrease central adiposity, but the effect of exercise dose and the relationship between central adiposity and exercise-induced compensation is unclear. Objective: Test the effect of exercise dose on central adiposity change and the association between central adiposity and exercise-induced weight compensation. Methods: In this ancillary analysis of a 6-month randomized controlled trial, 170 participants with overweight or obesity (mean ± SD body mass index: 31.5 ± 4.7 kg/m2) were randomized to a control group or exercise groups that reflected exercise recommendations for health (8 kcal/kg/ week [KKW]) or weight loss and weight maintenance (20 KKW). Waist circumference …

A Pragmatic Trial Of A Family-Centered Approach To Childhood Obesity Treatment: Rationale And Study Design, Amanda E. Staiano, Alyssa M. Button, Alison Baker, Robbie Beyl, Anne Marie Conn, Angela Lima, Jeanne Lindros, Robert L. Newton, Richard I. Stein, R. Robinson Welch, Stephen Cook, Denise E. Wilfley

Population and Public Health Science Faculty Publications

Background: Family-based behavioral treatment (FBT) is an effective intensive health behavior and lifestyle treatment for obesity reduction in children and adolescents, but families have limited access. The purpose of this randomized, pragmatic, comparative effectiveness trial was to examine changes in child relative weight in a 12-month, enhanced standard of care (eSOC) intervention combined with FBT (eSOC+FBT) vs. eSOC alone. Methods: Children aged 6 to 15 years with obesity, and their primary caregiver, were recruited from primary care clinics. Families were randomized 1:1 to eSOC, a staged approach led by the primary care provider that gradually intensified dependent on a child's …

Data Augmentation Enhances Plant-Genomic-Enabled Predictions, Osval A. Montesinos-López, Mario Alberto Solis-Camacho, Leonardo Crespo-Herrera, Carolina Saint Pierre, Gloria Isabel Huerta Prado, Sofia Ramos-Pulido, Khalid Al-Nowibet, Roberto Fritsche-Neto, Guillermo Gerard, Abelardo Montesinos-López, José Crossa

Faculty Publications

Genomic selection (GS) is revolutionizing plant breeding. However, its practical implementation is still challenging, since there are many factors that affect its accuracy. For this reason, this research explores data augmentation with the goal of improving its accuracy. Deep neural networks with data augmentation (DA) generate synthetic data from the original training set to increase the training set and to improve the prediction performance of any statistical or machine learning algorithm. There is much empirical evidence of their success in many computer vision applications. Due to this, DA was explored in the context of GS using 14 real datasets. We …