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The Rheological Analysis Of Ancestral Beverages, Neutrosophic C-Means (Ncm) Clustering Algorithm Of Data, Ana M. Trávez-Castellano, Gabriela B. Arias-Palma, Renato A. Romero-Corral

Neutrosophic Sets and Systems

This study focuses on the rheological analysis of cassava and chonta chichas (Manihot esculenta Crantz and Bactris gasipaes) produced in the Province of Pastaza, aiming to preserve and disseminate the cultural and nutritional heritage of these traditional beverages. The research emphasizes the integration of ancestral knowledge into modern production prac-tices, exploring sensory characteristics that could influence consumer preferences and production standardization. In Pas-taza, it has been observed that traditional production methods, such as chewing cassava and chonta to initiate fermentation, expose the product to microbial risks, making it potentially unpalatable and unsafe for consumption. To address these is-sues, this work …

Liver Disease And Transplantation In Telomere Biology Disorders: An International Multicenter Cohort, Yunzu Michele Wang, Batul Kaj-Carbaidwala, Adam Lane, Suneet Agarwal, Fabian Beier, Alison Bertuch, Kristin A Borovsky, Steven K Brennan, Rodrigo T Calado, Luiz Fernando B Catto, Carlo Dufour, Christen L Ebens, Francesca Fioredda, Neelam Giri, Nicholas Gloude, Frederick Goldman, Paula M Hertel, Ryan Himes, Sioban B Keel, Divya T Koura, Christian P Kratz, Sakil Kulkarni, Iris Liou, Taizo A Nakano, Silvia Nastasio, Marena R Niewisch, Daniel D Penrice, Ghadir S Sasa, Sharon A Savage, Douglas A Simonetto, David S Ziegler, Alexander G Miethke, Kasiani C Myers

Faculty, Staff and Students Publications

Background: Patients with telomere biology disorders (TBD) develop hepatic disease, including hepatitis, cirrhosis, and hepatopulmonary syndrome. No specific treatment exists for TBD-related liver disease, and the role of liver transplantation (LT) remains controversial. Our study objectives were to describe the clinical characteristics, management, and outcomes in patients with TBD-related liver disease, and their LT outcomes.

Methods: Data from 83 patients with TBD-associated liver disease were obtained from 17 participating centers in the Clinical Care Consortium of Telomere-Associated Ailments and by self-report for our retrospective, multicenter, international cohort study.

Results: Group A ("Advanced") included 40 patients with advanced liver disease. Of …

Response-Adapted Ultra-Low-Dose 4 Gy Radiation As Definitive Therapy Of Gastric Malt Lymphoma: A Single-Centre, Pilot Trial, Jillian R Gunther, Jie Xu, Manoop S Bhutani, Paolo Strati, Penny Q Fang, Susan Y Wu, Bouthaina S Dabaja, Wenli Dong, Priya R Bhosale, Christopher R Flowers, Ranjit Nair, Luis Malpica Castillo, Luis Fayad, Swaminathan P Iyer, Simrit Parmer, Michael Wang, Hun Ju Lee, Felipe Samaniego, Jason Westin, Sairah Ahmed, Chijioke C Nze, Preetesh Jain, Sattva S Neelapu, Maria A Rodriguez, Dai Chihara, Loretta J Nastoupil, Chelsea C Pinnix

Faculty, Staff and Student Publications

Background: Given the favourable prognosis of patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, treatment-related toxicity should be minimised. We aimed to evaluate the efficacy of 4 Gy radiotherapy given in a response-adapted approach.

Methods: We conducted a single-centre, single-arm, prospective trial at MD Anderson Cancer Center (Houston, TX, USA) of response-adapted ultra-low-dose radiotherapy. Eligible patients were 18 years or older and had newly diagnosed or relapsed Helicobacter pylori-negative gastric MALT lymphoma, with stage I-IV disease. Given the expected low toxicity profile of treatment, performance status was not an exclusion criterion. Patients received external beam photon-based radiotherapy for a total …

Homozygous Missense Variants In Ykt6 Result In Loss Of Function And Are Associated With Developmental Delay, With Or Without Severe Infantile Liver Disease And Risk For Hepatocellular Carcinoma, Mengqi Ma, Mythily Ganapathi, Yiming Zheng, Kai-Li Tan, Oguz Kanca, Kevin E Bove, Norma Quintanilla, Sebnem O Sag, Sehime G Temel, Charles A Leduc, Amanda J Mcpartland, Elaine M Pereira, Yufeng Shen, Jacob Hagen, Christie P Thomas, Nhu Thao Nguyen Galván, Xueyang Pan, Shenzhao Lu, Jill A Rosenfeld, Daniel G Calame, Michael F Wangler, James R Lupski, Davut Pehlivan, Paula M Hertel, Wendy K Chung, Hugo J Bellen

Faculty, Staff and Students Publications

PURPOSE: YKT6 plays important roles in multiple intracellular vesicle trafficking events but has not been associated with Mendelian diseases.

METHODS: We report 3 unrelated individuals with rare homozygous missense variants in YKT6 who exhibited neurological disease with or without a progressive infantile liver disease. We modeled the variants in Drosophila. We generated wild-type and variant genomic rescue constructs of the fly ortholog dYkt6 and compared their ability in rescuing the loss-of-function phenotypes in mutant flies. We also generated a dYkt6

RESULTS: Two individuals are homozygous for YKT6 [NM_006555.3:c.554A>G p.(Tyr185Cys)] and exhibited normal prenatal course followed by failure to thrive, …

Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation In Melanoma: Impact Of Antibiotic Preconditioning On Microbiome And Immunity, Isabella C Glitza, Yongwoo David Seo, Christine N Spencer, Jennifer R Wortman, Elizabeth M Burton, Farah A Alayli, Christopher P Loo, Shikha Gautam, Ashish Damania, Julie Densmore, Justin Fairchild, Christopher R Cabanski, Matthew C Wong, Christine B Peterson, Brian Weiner, Nathan Hicks, John Aunins, Christopher Mcchalicher, Emily Walsh, Michael T Tetzlaff, Omid Hamid, Patrick A Ott, Genevieve M Boland, Ryan J Sullivan, Kenneth F Grossmann, Nadim J Ajami, Theresa Lavallee, Matthew R Henn, Hussein A Tawbi, Jennifer A Wargo

Faculty, Staff and Student Publications

Gut-microbiota modulation shows promise in improving immune-checkpoint blockade (ICB) response; however, precision biomarker-driven, placebo-controlled trials are lacking. We performed a multicenter, randomized placebo-controlled, biomarker-stratified phase I trial in patients with ICB-naïve metastatic melanoma using SER-401, an orally delivered Firmicutesenriched spore formulation. Fecal microbiota signatures were characterized at baseline; patients were stratified by high versus low Ruminococcaceae abundance prior to randomization to the SER-401 arm (oral vancomycin-preconditioning/SER-401 alone/nivolumab + SER-401), versus the placebo arm [placebo antibiotic/placebo microbiome modulation (PMM)/nivolumab + PMM (NCT03817125)]. Analysis of 14 accrued patients demonstrated that treatment with SER-401 + nivolumab was safe, with an overall response rate …

Cholesterol-Dependent Lxr Transcription Factor Activity Represses Pronociceptive Effects Of Estrogen In Sensory Neurons And Pain Induced By Myelin Basic Protein Fragments, Swathi K Hullugundi, Jennifer Dolkas, Andrei V Chernov, Tony L Yaksh, Kelly A Eddinger, Mila Angert, Glaucilene Ferreira Catroli, Alex Y Strongin, Patrick M Dougherty, Yan Li, Oswal Quehenberger, Aaron Armando, Veronica I Shubayev

Faculty, Staff and Student Publications

BACKGROUND: A bioactive myelin basic protein (MBP) fragment, comprising MBP

METHODS: In male and female normal and post-CCI rat sciatic nerves, we assessed: (i) cholesterol precursor and metabolite levels by lipidomics; (ii) MBP

RESULTS: CCI regulated LXRα ligand and receptor levels in nerves of both sexes, with cholesterol precursors, desmosterol and 7-DHC, and oxysterol elevated in females relative to males. MBP

CONCLUSION: The injury-released bioactive MBP fragments induce pronociceptive changes by selective inactivation of nuclear transcription factors, including LXRα. By Ncoa1 sequestration, bioactive MBP fragments render LXRα function to counteract pronociceptive activity of estrogen/ESR1 in sensory neurons. This effect of …

Eus-Guided Hydrogel Injection To Separate Pancreatic Head Carcinoma From Duodenum For Enhanced Radiotherapy: Multi-Site Feasibility Study, Manoop S Bhutani, Amol K Narang, Kai Ding, Brenna Casey, Kumar Krishnan, Eugene J Koay, Theodore S Hong, Joseph M Herman, Kristen H Griffin, Eun Ji Shin

Faculty, Staff and Student Publications

Background and study aims The proximity of a pancreas head tumor to the duodenum often limits delivery of an ablative dose of radiation therapy. This study evaluated the feasibility and safety of using an injectable polyethylene glycol (PEG) hydrogel between the head of the pancreas and duodenum.

Patients and methods In a multi-site feasibility cohort study of patients with localized pancreatic cancer, PEG hydrogel was injected under endoscopic ultrasound guidance to temporarily position the duodenum away from the pancreas. Procedure characteristics were recorded, including hydrogel volume and space created. Patients were monitored for adverse events (AEs) and radiotherapy toxicity.

Results …

T. Boudieri Extract Potentiates The Effects Of Capecitabine Treatment In Human Colon Cancer Cells, Katia Sawaya, Mahmoud Khalil, Ghada Khawaja

BAU Journal - Science and Technology

Resistance to chemotherapy remains a major challenge for colorectal cancer patients worldwide, hence the persistent need to uncover alternative treatments as well as new adjunct therapies in the fight against cancer. Natural extracts constitute an excellent source of bioactive substances that have a promising potential in that regard, with minimal negative side effects. We have previously demonstrated that both the ethanolic as well as the water extracts of Terfezia boudieri, a black desert truffle abundant in and part of the cuisine of the Mediterranean region, have significant antiproliferative effects against colon cancer cells. Our aim in this study was …

Prevalensi Dan Karakteristik Pasien Tuberkulosis Paru Resisten Obat (Tb-Ro) Dengan Diabetes Melitus Tipe 2 Di Klinik Tb-Ro Rumah Sakit Umum Pusat Dr. Hasan Sadikin, Bandung, Diva Harnum Maulida, Intan Mauli Warma Dewi, Prayudi Santoso, Adi Imam Cahyadi, Maya Kusumawati, Iceu Dimas Kulsum

Jurnal Penyakit Dalam Indonesia

Introduction. Diabetes mellitus (DM) patients have a higher risk of tuberculosis (TB) infection, including the risk of drug- resistant (DR)-TB infection, compared to those without DM. Data on the characteristics of pulmonary DR-TB with DM in Indonesia are still very limited. The management of pulmonary DR-TB with DM should consider multiple factors, such as drug interactions between DM medication and anti-TB drugs, as well as potential exacerbation of DM complications by anti-TB drugs side effects. Effective management of pulmonary DR-TB patients with DM will improve treatment outcomes. This study aimed to determine the prevalence and characteristics of pulmonary DR-TB …

Development Of Poly-Vinyl Alcohol (Pva) And Moringa Oleifera-Based Nanofibre Patches For Wound Healing Using An Indigenous Electrospinning Setup, Suvarna Ghosh, Merla Sudha, Rakshith Prajwal R S, Sameer A Nadaf, Shreya R S, Pronama Biswas, Belaguppa Manjunath Ashwin Desai

Manipal Journal of Science and Technology

Wound healing is a crucial process that underlines the body’s ability to recover and restore damaged tissues. Conventional cotton-based dressings act as a physical barrier between the environment and open wound and are not actively involved in wound healing. This type of dressing can lead to maceration of scab, and infection and can cause pain upon removal. Functionalized nanofibre patches that can accelerate wound healing are being researched worldwide to overcome these challenges. Electrospinning has emerged as the most promising technique for engineering nanofibres for diverse applications. In this study, the wound-healing potential of PVA nanofibres functionalized with different concentrations …

The Effects Of Vitamin D On Chronic Wounds, Mufqi Handaru Priyanto, Eliza Miranda, Shannaz Nadia Yusharyahya, Lili Legiawati, Endi Novianto, Kusmarinah Bramono, Roro Inge Ade Krisanti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Wounds that fail to proceed through the normal healing process are referred to as chronic wounds, also known as ulcers. Chronic wounds have immeasurable biological, psychological, social, and economic effects, bringing tremendous challenges for patients, doctors, healthcare providers, and healthcare systems.

Discussion: This condition is associated with a variety of comorbidities and complex etiologies. The global incidence of chronic wounds is expected to increase with longer life expectancy. Thus, a holistic approach is necessary, such as proper wound management, proper control of comorbidities, and provision of adequate nutrition, including vitamin D supplementation. Vitamin D is an essential pro-hormone for …

Physical Activity And Depressive Symptoms In Youth, Katherine E. Spring, Amanda E. Staiano

Population and Public Health Science Faculty Publications

No abstract provided.

Investigating The Diversity In Physiological, And Molecular Responses Of Wheat (Triticum Aestivum L.) Genotypes Under Cadmium Stress, Haitham Mokhles Saad Khatlan, Mohammed Hamdan Al-Issawi, Hail Rihan

School of Biological and Marine Sciences

Heavy metal toxicity is a real threat to the environment, crop productivity, and the health of humans and their animals, especially when the toxicity enters the food chain. This study investigates the effect of cadmium on the physiological and molecular levels of ten introduced wheat genotypes. Genotypes were stressed by cadmium (75 mg.L^-1) in comparison with unstressed treatment to highlight their response to the cadmium. The experiment was laid out as a factorial arrangement in RCBD, with three replicates. The genotypes included in this study varied in their response to cadmium stress during the laboratory tests. Notably, genotype …

Efficiency Of 7-Dehydrocholesterol Vitamin-D3 Complex Cream For Xerosis And Pruritus In Elderly Women, Yulia Farida Yahya, Meirina Rahmadini, Pandu Haryo Jatmiko, M. Afif Baskara Emirzon, Dewa Ayu Bulan Nabila, Yuli Kurniawati, Theresia Lumban Toruan, Nur Riviati

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Xerosis and pruritus (XP) are the most common skin conditions in the elderly, manifesting clinically as roughness, scales, fissures, and mild-to-severe itching. Vitamin D improves skin hydration, transepidermal water loss (TEWL), and regulates the immune system. We aimed to determine the efficiency of topical 7-dehydrocholesterol (DHC)-vitamin D3 complex cream in elderly patients with XP.

Methods: An experimental phase III study was performed on elderly women with XP from December 2021 to March 2022 at the Geriatric Dermatology Clinic of Dr. Mohammad Hoesin General Hospital, Palembang. Inclusion criteria were age older than 55 years, healthy or with comorbidity. The exclusion …

The Impact Of Integrating Play Exercises With Learning Aids On Teaching Fundamental Basketball Skills To Preparatory School Girls, Suzan Sabah Ahmed, Mawahib Hameed Noman

Modern Sport

The purpose of the research is to identify the effect of the advanced figurative organizations’ strategy in developing the skill of receiving serve in volleyball among the female students of the middle school stage of Baghdad Al-Karkh Education in the (Safiya Bint Abdul Muttalib) Secondary School for Girls. The problem of the research is that the female students need something that will enable them to increase their ability to break out of the repetitive monotony of performance. The same thing, but the nature of the repetitive performance at this pace limited their ideas in overcoming the weaknesses that appeared clearly …

Implementation Of Specific Nutrition Interventions To Prevent Stunting In Pregnant Women In The Oesapa Community Health Center Area East Nusa Tenggara, Septa Katmawanti, Oktavia Sri Wahyuni, Farah Paramita, Agung Kurniawan, Siti Khuzaimah

Preventia: The Indonesian Journal of Public Health

Policies related to stunting prevention have been in place since 2013. However, the prevalence of stunting in East Nusa Tenggara Province is still the highest in Indonesia from 2013 to 2022. One of the areas in the province where the prevalence decreased from 2021 to 2022 is Kupang City. Oesapa Community Health Centre was appointed by the Indonesian Ministry of Health as a pilot health centre representing Kupang City. The purpose of this study is to describe the implementation of specific nutritional interventions for handling stunting based on the variables of communication, bureaucratic structure, resources, and disposition in the target …

Knowledge And Attitudes Of Food Hosters Towards Personal Hygiene And Description Of The Existence Of E. Coli And Salmonella Sp In Pesantren, Siti Muthi’Ah Azzahro, Milliyantri Elvandari, Eka Andriani

Bulletin of Culinary Art and Hospitality

Personal hygiene is a health practice carried out when processing food. Lack of implementation of personal hygiene will have an impact on a person's health, such as experiencing food poisoning. The growth of a person's personal hygiene practices can be influenced by knowledge and attitudes. This research explores the knowledge and attitudes of food handlers towards personal hygiene using qualitative and quantitative approaches. A quantitative approach was performed with a cross-sectional design and a qualitative with a descriptive design. Sampling was taken using a total sampling technique, thereby, all food handlers were sampled, resulting in 30 respondents. Data analysis was …

Effect Of Steam And Microwave Blanching Against Enzymatic Browning Of Chilled Saba Banana (Musa Spp., Bbb), Mansoor Abdul Hamid, See Chee Hian, Oslida Martony, Mazarina Devi

Bulletin of Culinary Art and Hospitality

The browning process, either enzymatic or non-enzymatic, is commonly used in food processing. Most browning process is avoided to maintain the food products' quality. This study was carried out to investigate the effect of steam blanching and microwave blanching against the enzymatic browning of chilled Saba bananas (Musa spp., BBB). The steam and microwave blanching in a range of 3 to 11 minutes and 30 to 90 seconds, respectively, were carried out to investigate the efficiency of deactivating the activity of the enzyme polyphenol oxidase (PPO). The results indicated that steam blanching for 7 minutes (SB7) and microwave blanching for …

Utilization Of Patin Fish Oil As An Additional Ingredient In Making Shredded Cookies, Agung Arif Gunawan, Arina Luthfini Lubis+N6, Syafira Melania

Bulletin of Culinary Art and Hospitality

Shark catfish, a common freshwater species found in Koto Masjid village, is renowned for its high fat content which primarily consists of unsaturated fatty acids, such as linoleic acid, linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). In this research experiment, shark catfish oil was incorporated as an additional ingredient in shredded cookies. The objective was to evaluate organoleptic aspects such as taste, scent, texture, and color of shredded cookies using the hedonic quality test scale and hedonic test. Statistical analysis involved the Kruskal-Wallis test and the Mann-Whitney test. The study involved 25 examiners, including 10 trained and 15 …

Impact Of Infancy Conditions On Physical Growth Of Children Under-Five, Claudia Azhari, Yeni Mahwati, Yeni Suryamah, Arfian Hikmat Ramdan

Preventia: The Indonesian Journal of Public Health

Children under five years old is the age group most vulnerable to several health problems. It is important to evaluate the impact of infancy condition on their physical growth. This research aimed to examine the impact of infancy condition on the physical growth of children under-five years old. The unmatched case-control study was conducted in Puskesmas Griya Antapani areas, Bandung from May to July, 2023. A total of 112 children aged under 5 years were included in this study (56 cases and 56 control). The analysis used multivariate logistic regression to determine adjusted odds ratios (OR). The results showed that …

The Effectivity Of Nutrition Education Using E-Booklet On Knowledge And Attitude About Anemia Among Adolescent Girls In Turen Malang, Farah Paramita, Windi Chusniah Rachmawati, Rany Ekawati, Haura Salwa Aulia Pherenis, Selsa Tri Septiani, Meisya Awaliahmunazila

Preventia: The Indonesian Journal of Public Health

One of the nutritional problems of adolescent female in Southeast Asia is iron deficiency anemia, with an estimated 25-40 percent of adolescent female experiencing mild to severe anemia. The impact of this on teenagers is a decline in academic abilities at school due to a lack of enthusiasm for learning and concentration on learning. This research aims to determine the effect of e-booklet anemia prevention media on young women at SMAN 1 Turen. This research uses an experimental method, namely a pre-experimental design with a one group pretest-posttest approach. The subjects of this research were 50 female students. The results …

Blood Pressure Analysis Based On Nutritional Status And Lifestyle In Employees With Hypertension, Yessy Kurniati, Aminuddin Syam, Wahiduddin Wahiduddin, Zaenal Zaenal, Ahmad Arif Hidayat

Preventia: The Indonesian Journal of Public Health

The incidence of hypertension continues to increase. Hypertension is related to lifestyle and nutritional status. This study aimed to analyze blood pressure based on the nutritional status and lifestyle of employees with hypertension. An analytic study with a cross-sectional design was conducted from July to September 2022 by recruiting all Hasanuddin University rectorate employees with hypertension. The total number of respondents in this study was 63 people. Data was collected by measuring blood pressure and anthropometry, while lifestyle risk factors were collected using a questionnaire. Pearson correlation was performed to measure the correlation between blood pressure and nutritional status. A …

Exploring The Impact Of Dark Chocolate Intake On Insulin Resistance, Stress Hormones, And Potassium Regulation, Reem Hussein Hamza, Maysaa Jalal Majeed, Muataz Fawzi Hussein

Modern Sport

The investigation into notable improvements in insulin resistance and the regulation of stress hormones, with a specific focus on potassium levels, constitutes a captivating field of research. This study aims to delve into the potential influence of consuming dark chocolate on these critical physiological aspects. In aims, this research endeavors to comprehensively examine and assess the potential significant improvements in insulin resistance and the regulation of stress hormones and potassium associated with the intake of dark chocolate. In materials and method, this study included 162 individuals aged between (40-60) years. they were divided into two groups. group one contains 80 …

Testosterone And Cortisol Hormones Response And Some Functional Variables To Escalated Aerobic Physical Exercise With The Difference Of Biological Timing, Omar Aladdin Ahmed

Modern Sport

The current study aimed to: Detect the effect of physical effort of increasing intensity on a number of functional variables: testosterone, cortisol, heart rate, and systolic blood pressure in morning and evening times. As well as detecting the effect of the difference in morning and evening biological timing at times of rest and effort on a number of functional variables: testosterone, cortisol, heart rate, and systolic blood pressure rate. The descriptive approach was used for its suitability for the nature of the study. The sample consisted of (8) individuals selected randomly, aged between (21-23 years) who practiced sports activity. The …

Exploring The Impact Of The Ketogenic Diet On Thyroid Function, Khamael Hasan Obaid, Maysaa Jalal Majeed

Modern Sport

This study aims to highlight the connection between thyroid health and the ketogenic diet. This study included 120 men aged between (25- 55) years, divided into two groups. Group one contains 70 men following a carbohydrate diet, and group two is 50 men who follow a ketogenic diet; both groups analyzed serum (TSH, T4, T3) and HbA1c.

Jump To Box Kombinasi Core Plank Knee To Elbow Terhadap Power Otot Tungkai, Maya Triyanita

Jurnal Fisioterapi Terapan Indonesia

Leg power training is defined as a movement to get the jump in athletes doing the maximum jump smash. Badminton requires leg muscle explosive power because it is the muscle's ability to overcome loads and with a high speed of contraction. This study aims to determine differences in the effect of jump to box training, a combination of core plank knee to elbow on increasing leg power in badminton athletes. This study used an experimental design method with a pre-test and post-test design. The treatment group was given the Jump To Box Combination Core Plank Knee To Elbow exercise. The …

Factors Affecting The Success Of Exclusive Breastfeeding Among Mothers Recovered From Covid-19, Ulfatul Latifah, Nora Rahmanindar, Ardhi Henda Karmandika

Media Kesehatan Masyarakat Indonesia

Exclusive breastfeeding for the first 6 months and continued breastfeeding with complementary foods up to 2 years are emphasized by the World Health Organization. Amid the COVID-19 pandemic, maternal concerns about virus transmission through breastfeeding have surfaced. Despite these concerns, breastfeeding remains the primary recommendation due to its manifold health benefits. This research, conducted in Tegal City's Margadana sub-district, investigates factors influencing exclusive breastfeeding success among mothers recovered from COVID-19. Using an analytical observational design with a cross-sectional approach, the study explores the link between COVID-19 symptoms in infants and exclusive breastfeeding success, revealing a significant correlation (p-value=0.042). Conversely, breast …

Immunomodulators In Leprosy: A Narrative Review, Kesya Kimberly, Siti Aisha Nabila Ferina, Prima Kartika Esti

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. Current therapeutic regimen, like the multidrug therapy (MDT), are effective in treating most cases, but new cases continue to emerge in Indonesia every year. While multidrug therapy alone is adequate for treating leprosy, there is a need for adjuvant treatment options to boost the host’s immune system to prevent the worsening of leprosy and reduce the activation of M. leprae, such as immunomodulators.

Discussion: Immunomodulators are drugs that can stimulate the body’s natural and adaptive defense mechanisms, acting as either immunosuppressants or immunostimulants. To understand …

Contribution To Hair And Skin Science In Indonesia Through A Research Grant Program, Michele Verschoore, Rhadeya Setiawan, Muhammad Yulianto Listiawan, Nurtami Nurtami, Eloïse Moreau De Montcheuil

Journal of General - Procedural Dermatology and Venereology Indonesia

To foster scientific advances in basic and clinical research projects, a philanthropic "hair & skin research grant" program was launched in 2021 through a partnership between University of Indonesia, Perdoski, and L’Oreal Research and Innovation. The aim of the program is to empower Indonesian scientists to generate research data on general skin and hair issues that affect the Indonesian population. We have grouped the eight grant projects awarded between 2021 and 2022 into five main themes: skin type characterization; skin microbiota; botanical extracts; photoaging therapies; and hair loss. The various studies are evaluating potential therapies for acne, skin aging, photoaging …

Hubungan Antara Partisipasi Dalam Pengambilan Keputusan Kesehatan Perempuan Dengan Kehamilan Yang Tidak Diinginkan, Maria Anastasia Audrey, Sudarto Ronoatmodjo

Jurnal Epidemiologi Kesehatan Indonesia

Prevalensi Kehamilan Tidak Diinginkan (KTD) di Indonesia mencapai 10,7% pada tahun 2021. Pada wanita yang sudah menikah, keputusan kesehatan mencakup keputusan tentang kontrasepsi, yang idealnya melibatkan partisipasi perempuan bersama suaminya agar dapat dilakukan secara konsisten sehingga dapat mencegah KTD. Namun, data tahun 2017 menunjukkan proporsi pengambilan keputusan kesehatan perempuan yang dilakukan perempuan bersama suami hanya sebesar 43,7%. Penelitian ini bertujuan untuk mengetahui hubungan antara partisipasi bersama antara istri dan suami dalam pengambilan keputusan kesehatan perempuan dengan terjadinya KTD. Penelitian ini menggunakan desain studi crosssectional dengan menganalisis data Survei Demografi dan Kesehatan Indonesia tahun 2017. Kriteria inklusi sampel adalah perempuan yang …