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2024

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The Effect Of Chronic Administration Of Amphetamine-Type Stimulants On Oxidative Stress And Inflammation In Wistar Rats, Vita Camellia, Fasihah Irfani Fitri, Muhammad Ichwan, Dina Keumala Sari, Elmeida Effendy, Aldy Safruddin Rambe, Syafruddin Ilyas, Juliandi, Alfi Khatib, Mustafa Mahmud Amin, Muhammad Rusda Jul 2024

The Effect Of Chronic Administration Of Amphetamine-Type Stimulants On Oxidative Stress And Inflammation In Wistar Rats, Vita Camellia, Fasihah Irfani Fitri, Muhammad Ichwan, Dina Keumala Sari, Elmeida Effendy, Aldy Safruddin Rambe, Syafruddin Ilyas, Juliandi, Alfi Khatib, Mustafa Mahmud Amin, Muhammad Rusda

Baghdad Science Journal

This study aims to determine the effect of chronic administration of amphetamine-type stimulants at varying doses on inflammation and oxidative stress in Wistar rats. They were given methylphenidate and divided into 4 treatment groups. Furthermore, simple random grouping was carried out to divide the samples into 5 groups, each consisting of 9 rats. These groups included rats given only distilled water as the controls, as well as those given methylphenidate at doses of 10 mg/kg BW, 20 mg/kg BW, and 40 mg/kg BW for 4 weeks as the experimental groups. Statistical analysis was then performed using GraphPad Prism to compare …


Retrospective Analysis Of The Clinical Utility Of Multi-Cytokine Profiles In Smear-Negative Pulmonary Tuberculosis, Xuemei Li, Weidong Zhao, Hong Han, Zhi Yang, Fengqing Bi, Yingchun He Jul 2024

Retrospective Analysis Of The Clinical Utility Of Multi-Cytokine Profiles In Smear-Negative Pulmonary Tuberculosis, Xuemei Li, Weidong Zhao, Hong Han, Zhi Yang, Fengqing Bi, Yingchun He

Saudi Medical Journal

Objectives: To evaluate cytokine profiles and interferon-gamma release assay (IGRA) for their diagnostic capabilities in the differentiation of tuberculosis (TB) from non-TB conditions, as well as smear-negative pulmonary tuberculosis (SNPT) from smear-positive pulmonary tuberculosis (SPPT). Methods: A total of 125 participants were included, 77 of whom had TB and 48 who didn’t, and demographic, clinical, and laboratory data were collected, including cytokine levels and IGRA results. The TB patients were further divided into 2 subgroups: SNPT (n=42) and SPPT (n=35). Results: Compared to non-TB, the TB group had lower BMI, higher WBC, neutrophils, monocytes, ESR and CRP ( p <0.05). TB patients showed higher IL-2, IL-6, IFN-γ, IL-8 ( p <0.001) and higher IGRA positivity (88.3% versus [vs.] 29.2%, p <0.001). Between SNPT and SPPT, moderate effect sizes were observed for IFN-α, IL-2, IL-10, IL-8 (Cohen’s d 0.59-0.76), with lower IGRA positivity in SNPT (81.0% vs. 97.1%, p =0.015). ROC analysis indicated IFN-α, IL-2, IL-10, IL-8 had moderate accuracy for SNPT diagnosis (AUCs 0.668-0.734), and combining these improved accuracy (AUC 0.759, 80% sensitivity, 64.2% specificity). Conclusion: A multi-biomarker approach combining these cytokines demonstrates enhanced diagnostic accuracy for tuberculosis.


Exploring Burnout Program Effectiveness With Adult Day Health Providers, Katy R. Maguire Jul 2024

Exploring Burnout Program Effectiveness With Adult Day Health Providers, Katy R. Maguire

OTD DEx Reports - College of Pharmacy and Health Sciences

"Stress and burnout are frequently experienced by those in healthcare professions. While extensive research has been done on the impact of stress and burnout on nurses and physicians, other healthcare fields are less researched. One of these populations of health providers excluded from current studies is adult day health providers. Health providers at adult day health centers provide specialized services to persons with acquired, developmental, and intellectual disabilities. They orient these individuals to the community, administer their medications, provide opportunities for socialization and learning, accommodate leisure activities, and many other services that promote community and personal independence for their clients. …


Understanding Differential Reductions In Undernutrition Among Districts In Rwanda Through The Perspectives Of Mid-Level And Community Actors On Policy Commitment And Policy Coherence, Elyse Iruhiriye, Edward A. Frongillo Ph.D., Deanna K. Olney, Emmanuel Niyongira, Simeon Nanama, Christine E. Blake Ph.D., Rd, Eugene Rwibasira, Paul Mbonyi Jul 2024

Understanding Differential Reductions In Undernutrition Among Districts In Rwanda Through The Perspectives Of Mid-Level And Community Actors On Policy Commitment And Policy Coherence, Elyse Iruhiriye, Edward A. Frongillo Ph.D., Deanna K. Olney, Emmanuel Niyongira, Simeon Nanama, Christine E. Blake Ph.D., Rd, Eugene Rwibasira, Paul Mbonyi

Faculty Publications

Understanding the drivers of improvements in child undernutrition at only the national level can mask subnational differences. This paper aimed to understand the contributions of factors in the enabling environment to observed differences in stunting reduction between districts in Rwanda. In 2017, we conducted 58 semi-structured interviews with mid-level actors (n = 38) and frontline workers (n = 20) implementing Rwanda's multi-sectoral nutrition policy in five districts in which stunting decreased (reduced districts) and five where it increased or stagnated (non-reduced districts) based on Rwanda's 2010 and 2014/15 Demographic and Health Surveys. Mid-level actors are government officials and service providers …


They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz Jul 2024

They See Themselves In The Lesson: Leveraging Students’ Scientific And Cultural Insights Through The Cultural Biohealth Synergy Science Curriculum [Se Ven A Sí Mismos En La Lección: Aprovechando Los Conocimientos Científicos Y Culturales De Los Estudiantes A Través Del Currículo De Ciencias De Sinergia De Bio Salud Cultural], Miriam M. Ortiz

Theses and Dissertations

In response to the global crisis of type 2 diabetes prevalence, this dissertation investigated the impact of a culturally sustaining, health-centric science curriculum contextualized in type 2 diabetes. Using a case study methodology, it explored how the curriculum shaped math and science preservice teachers’ (PSTs) perceptions of science and how it can be taught and how prepared they felt to design and implement culturally sustaining, health-centric lessons. Four themes that emerged across both cases included: 1) connecting health, nutrition, everyday science, and culturally sustaining pedagogy through the CBSS curriculum, 2) connecting science to health and wellness concepts through the CBSS …


Development Of A Mechanical Boot For Prevention Of Deep Vein Thrombosis In Outpatients, Julian David Trevino Jul 2024

Development Of A Mechanical Boot For Prevention Of Deep Vein Thrombosis In Outpatients, Julian David Trevino

Theses and Dissertations

This work presents the development of a mechanical boot designed to prevent Deep Vein Thrombosis (DVT) in high-risk individuals such as those who have just had major procedures. DVT is a serious condition characterized by the formation of blood clots in the deep veins, particularly of the lower limbs, which can lead to life-threatening complications if not adequately addressed. The mechanical boot utilizes the principle of Continuous Passive Motion (CPM) to facilitate blood flow in the lower extremities, thereby mitigating the risk of clot formation. Through a combination of mechanical engineering, biomedical research, and user centered design, the project outlines …


Reliability Of The Cvms Method To Assess The Craniofacial Growth Spurt, Holly Ingersoll Jul 2024

Reliability Of The Cvms Method To Assess The Craniofacial Growth Spurt, Holly Ingersoll

Master's Theses (2009 -)

Objective: Cervical vertebral maturation staging (CVMS) is a popular method to determine the growth potential of a child utilizing the changing shapes of C2, C3, and C4. Staging is separated into six stages where the first two stages are before the growth spurt, the second two stages are during the growth spurt, and the last two stages are after the growth spurt. This method is highly practical because it is read on a lateral cephalogram, a radiograph taken by the orthodontist for diagnostic records. However, many clinicians question its reliability and validity as a test. The objective of this study …


Comparing Goldin And The Philippines: Analyzing The Research Efforts In Women And Labor Economics Using Basic Text Mining Techniques, Arianna Liza Ortillan Jul 2024

Comparing Goldin And The Philippines: Analyzing The Research Efforts In Women And Labor Economics Using Basic Text Mining Techniques, Arianna Liza Ortillan

Angelo King Institute for Economic and Business Studies (AKI)

No abstract provided.


Incorporating Ultrasonography To The Nutritional Assessment Process In Intensive Care Settings To Improve The Prescription Of Enteral And Parenteral Nutrition: Benefits, Practicality, And Challenges, Sara Zaher Jul 2024

Incorporating Ultrasonography To The Nutritional Assessment Process In Intensive Care Settings To Improve The Prescription Of Enteral And Parenteral Nutrition: Benefits, Practicality, And Challenges, Sara Zaher

Saudi Medical Journal

The validity of the traditional nutritional assessment tools in intensive care settings might be compromised when the patient has conditions such as oedema and inflammation. Ultrasound (US) is considered a non-invasive, bedside tool that can be utilized to assess changes in muscle mass. Hence, US could guide healthcare practitioners in identifying the varying degrees of malnutrition and adjusting the nutritional prescription accordingly. This review discusses the currently available data regarding the feasibility and practicality of using US measurements in intensive care settings. Overall, the data suggest that using US as part of the standard anthropometric assessment for critically ill patients …


A Cross-Sectional Analysis Of Preterm Birth Incidence And Survival In Al Kharj, Saudi Arabia, Mshari Alghadier, Muneera Alasraj, Ragab Elnaggar, Mashael Alazmi, Asma Aldawsari, Saud Alnadah, Faisal Alqahtani, Donia Zaghamir Jul 2024

A Cross-Sectional Analysis Of Preterm Birth Incidence And Survival In Al Kharj, Saudi Arabia, Mshari Alghadier, Muneera Alasraj, Ragab Elnaggar, Mashael Alazmi, Asma Aldawsari, Saud Alnadah, Faisal Alqahtani, Donia Zaghamir

Saudi Medical Journal

Objectives: To understand the prevalence and survival rates of preterm birth (PTB) is of utmost importance in informing healthcare planning, improving neonatal care, enhancing maternal and infant health, monitoring long-term outcomes, and guiding policy and advocacy efforts. Methods: The medical records of preterm infants admitted to the Neonatal Intensive Care Unit (NICU) with a diagnosis of prematurity at the Maternity and Children’s Hospital (MCH), Al Kharj, Saudi Arabia, were reviewed between January 2018 and December 2022. Data were collected on birth weight (BW), gender, number of live births, gestational age, mortality, nationality, APGAR score, length of stay in the NICU, …


Foreign Body Ingestion, Children's Mercy Kansas City Jul 2024

Foreign Body Ingestion, Children's Mercy Kansas City

Clinical Pathways

No abstract provided.


School-Wide Policies To Support Ell Students With Lgbtqia+ Identities, Camille Verly Jul 2024

School-Wide Policies To Support Ell Students With Lgbtqia+ Identities, Camille Verly

School of Education and Leadership Student Capstone Projects

My research question is What school-wide policies can be implemented to support ELL students with LGBTQIA+ identities? LGBTQIA+ high school students face a myriad of challenges in achieving full integration within academic and school culture. These challenges are especially pronounced for students from an English Language Learner (ELL) background, who may also grapple with language barriers and cultural differences. This intersectional group is at higher risk of marginalization, and as such, they are in particular need of holistic support within their educational environment. This project is the development of a comprehensive website designed to serve as a resource for all …


Experiential Gardening For Environmental Literacy And Food Systems Awareness, Adam De Leeuw Jul 2024

Experiential Gardening For Environmental Literacy And Food Systems Awareness, Adam De Leeuw

School of Education and Leadership Student Capstone Projects

School and community gardens have a rich history from the late 19th Century to the present, which includes the voices of Agassiz, Greene, Dewey, Washington Carver, Du Bois, and Montessori. This history spans the periods of school gardens from ‘nature study,’ the School Garden Army, Victory Gardens, the Tbilisi Declaration, and Garden-based learning. The purpose of this capstone project was to answer the following question: What are the individual lessons needed in a curriculum to support and connect experiential school and community garden programs for K-2 youth to serve as effective educational tools for environmental literacy and food systems awareness? …


Creating Outdoor Learning Opportunities For Neurodiverse Students: An Outdoor Learning Curriculum For Neurodiverse Students, Erin Barnes Jul 2024

Creating Outdoor Learning Opportunities For Neurodiverse Students: An Outdoor Learning Curriculum For Neurodiverse Students, Erin Barnes

School of Education and Leadership Student Capstone Projects

This project aimed to answer the question, how can special education teachers provide outdoor learning opportunities for neurodiverse students? The benefits of outdoor learning are well-researched and documented. Spending time in nature reduces stress levels and positively impacts mental health. However, many neurodiverse students in special education settings have limited access to outdoor learning due to concerns about safety, accessibility, and lack of training in environmental education for special education teachers. The need for access to outdoor learning is especially true for students in more restrictive special education settings. This project addresses barriers by providing outdoor learning opportunities that are …


Exploring The Relationships Between Food Insecurity, Wic Participation, Early Life Feeding Practices, Diversity Of Dietary Exposures, And Diet Quality In The First Two Years Of Life, Vivian M. Drewelow Jul 2024

Exploring The Relationships Between Food Insecurity, Wic Participation, Early Life Feeding Practices, Diversity Of Dietary Exposures, And Diet Quality In The First Two Years Of Life, Vivian M. Drewelow

Master's Theses

Diet quality during early childhood is a strong predictor of mental and physical outcomes, as well as future diet quality. Although many factors determine diet quality during childhood, food insecurity is a significant predictor of lower diet quality. On the other hand, participation in nutrition assistant programs, such as the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a significant predictor of higher diet quality. In addition, specific feeding practices, including timing of complementary food and beverage (CFB) introduction, types of CFB introduced early, and diversity of dietary exposures (DD), in the first year may predict future …


Collegiate Student-Athlete Responses To The Covid-19 Pandemic, Alexa Jenny Chandler Jul 2024

Collegiate Student-Athlete Responses To The Covid-19 Pandemic, Alexa Jenny Chandler

Theses and Dissertations

Introduction: Exercise imposes a physiological stressor on the body which is amplified as training intensifies. Collegiate fall-sport student-athletes return after summer break (off-season) and have approximately two weeks of training (preseason) with coaching staff before competition begins. The 2020 fall season was preceded by a five-month period away from campus due to the timing of the coronavirus 2019 (COVID-19) pandemic. This also meant all commercial gyms and training facilities were closed, and student-athletes were forced to train with the resources they had at home. Upon return to campus, significant changes were made to practice and competition structures in attempt to …


Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor Jul 2024

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC …


An Examination Of Self-Identity In Relation To Smoking And Vaping In South Carolina, Jaron Hoani King Jul 2024

An Examination Of Self-Identity In Relation To Smoking And Vaping In South Carolina, Jaron Hoani King

Theses and Dissertations

BACKGROUND

This dissertation examines self-identity in the context of smoking and vaping among adults in South Carolina (SC) using data from the 2023 SC Adult Tobacco Survey (n=1370). The conceptual model created to guide this dissertation is called the “Smoker and Vaper Behavior-Identity Model” and draws constructs from theoretical frameworks in health behavior and social identity theories. Behavior was defined as lifetime and past 30 day cigarette or e-cigarette use. Self-identity was defined by asking respondents with a history of cigarette or e-cigarette use “Do you consider yourself a smoker/vaper”, respectively.

METHODS

First, this study assesses the prevalence of mismatching …


Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor Jul 2024

Examining Risk Factors For Early-Onset Breast Cancer, Jennifer Grace Taylor

Theses and Dissertations

Introduction: There have been great advancements in screening and in the identifying of risk factors associated with breast cancer, however, there is a lack of information of these factors in women with breast cancer occurring under the age of 45, known as early-onset breast cancer (EOBC). EOBC is often found at later stages, negatively impacting young women’s careers, family planning, and mental health. Additionally, because of the health disparities that exist within the U.S. health care system, women belonging to racial and ethnic groups, specifically young Black women, tend to have poorer outcomes and higher mortality rates of EOBC compared …


Preparation, And Evaluation Of Waste Ground Tyre Rubber As Antioxidant, Antibacterial Activity And Anticorrosion Inhibitor For N80 Steel In 0.1n H3po4, Naeem T. Faili, Khawlah S. Burghal Jul 2024

Preparation, And Evaluation Of Waste Ground Tyre Rubber As Antioxidant, Antibacterial Activity And Anticorrosion Inhibitor For N80 Steel In 0.1n H3po4, Naeem T. Faili, Khawlah S. Burghal

Baghdad Science Journal

In this work, polybutadiene (PBD) was prepared from waste tires. The halogenated of polybutadiene was grafted with mono, di, and triethanolamine, the grafting was studied by X-ray diffraction and scanning electron microscopy. And according to the thermal characteristics (TGA and DSC), the produced compound was thermally stable up to 202 °C. Using potentiodynamic polarization techniques, the adsorption and corrosion inhibiting effects of three grafting polymers on N80 steel in 0.1 N H3PO4 as aggressive environments were measured at four different temperatures: 25, 35, 45, and 55°C. The prepared polymers have excellent inhibition efficiency at high temperatures. The pBut-g-mono ethanol amine …


Modal Sosial Keagamaan Dan Partisipasi Perempuan Muslim Indonesia Dalam Perburuhan, Rahma Nida, Yunisvita Yunisvita, Gustriani Gustriani Jul 2024

Modal Sosial Keagamaan Dan Partisipasi Perempuan Muslim Indonesia Dalam Perburuhan, Rahma Nida, Yunisvita Yunisvita, Gustriani Gustriani

Jurnal Ekonomi dan Pembangunan Indonesia

In recent years, the muslim majority countries’ focus on women’s labor force participation has grown, particularly Indonesia which stands out with its high female labor force participation rate. We aim to shed light on the relationship between religion and work decisions in Indonesia, employing data from the World Value Survey and utilizing logistic regression analysis. Our findings reveal that active participation in religious activities positively affects muslim women’s likelihood of working part-time and in the agricultural sector. Through the results, policymakers and relevant stakeholders can consider leveraging religious organizations as potential channels for promoting women’s labor force participation.


Association Of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma And Skin Carotenoid Concentrations In Adults Provided A Lycopene-Rich Juice, Anna C Norman, Daniel G Palmer, Nancy E Moran, James N Roemmich, Shanon L Casperson Jul 2024

Association Of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma And Skin Carotenoid Concentrations In Adults Provided A Lycopene-Rich Juice, Anna C Norman, Daniel G Palmer, Nancy E Moran, James N Roemmich, Shanon L Casperson

Children’s Nutrition Research Center Staff Publications

Background: Carotenoids are fat-soluble phytochemicals with biological roles, including ultraviolet protective functions in skin. Spectroscopic skin carotenoid measurements can also serve as a noninvasive biomarker for carotenoid consumption. Single-nucleotide polymorphisms (SNPs) in metabolic genes are associated with human plasma carotenoid concentrations; however, their relationships with skin carotenoid concentrations are unknown.

Objectives: The objective of this study was to determine the relationship between 13 candidate SNPs with skin and plasma carotenoid concentrations before and after a carotenoid-rich tomato juice intervention.

Methods: In this randomized, controlled trial, participants (n = 80) were provided with lycopene-rich vegetable juice providing low (13.1 mg), medium …


Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong Jul 2024

Understanding The Genetic Complexity Of Puberty Timing Across The Allele Frequency Spectrum, Katherine A Kentistou, Lena R Kaisinger, Stasa Stankovic, Marc Vaudel, Edson Mendes De Oliveira, Andrea Messina, Robin G Walters, Xiaoxi Liu, Alexander S Busch, Hannes Helgason, Deborah J Thompson, Federico Santoni, Konstantin M Petricek, Yassine Zouaghi, Isabel Huang-Doran, Daniel F Gudbjartsson, Eirik Bratland, Kuang Lin, Eugene J Gardner, Yajie Zhao, Raina Y Jia, Chikashi Terao, Marjorie J Riggan, Manjeet K Bolla, Mojgan Yazdanpanah, Nahid Yazdanpanah, Jonathan P Bradfield, Linda Broer, Archie Campbell, Daniel I Chasman, Diana L Cousminer, Nora Franceschini, Lude H Franke, Giorgia Girotto, Chunyan He, Marjo-Riitta Järvelin, Peter K Joshi, Yoichiro Kamatani, Robert Karlsson, Jian'an Luan, Kathryn L Lunetta, Reedik Mägi, Massimo Mangino, Sarah E Medland, Christa Meisinger, Raymond Noordam, Teresa Nutile, Maria Pina Concas, Ozren Polašek, Eleonora Porcu, Susan M Ring, Cinzia Sala, Albert V Smith, Toshiko Tanaka, Peter J Van Der Most, Veronique Vitart, Carol A Wang, Gonneke Willemsen, Marek Zygmunt, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Antonis C Antoniou, Paul L Auer, Catriona L K Barnes, Matthias W Beckmann, Amy Berrington De Gonzalez, Natalia V Bogdanova, Stig E Bojesen, Hermann Brenner, Julie E Buring, Federico Canzian, Jenny Chang-Claude, Fergus J Couch, Angela Cox, Laura Crisponi, Kamila Czene, Mary B Daly, Ellen W Demerath, Joe Dennis, Peter Devilee, Immaculata De Vivo, Thilo Dörk, Alison M Dunning, Miriam Dwek, Johan G Eriksson, Peter A Fasching, Lindsay Fernandez-Rhodes, Liana Ferreli, Olivia Fletcher, Manuela Gago-Dominguez, Montserrat García-Closas, José A García-Sáenz, Anna González-Neira, Harald Grallert, Pascal Guénel, Christopher A Haiman, Per Hall, Ute Hamann, Hakon Hakonarson, Roger J Hart, Martha Hickey, Maartje J Hooning, Reiner Hoppe, John L Hopper, Jouke-Jan Hottenga, Frank B Hu, Hanna Huebner, David J Hunter, Helena Jernström, Esther M John, David Karasik, Elza K Khusnutdinova, Vessela N Kristensen, James V Lacey, Diether Lambrechts, Lenore J Launer, Penelope A Lind, Annika Lindblom, Patrik K E Magnusson, Arto Mannermaa, Mark I Mccarthy, Thomas Meitinger, Cristina Menni, Kyriaki Michailidou, Iona Y Millwood, Roger L Milne, Grant W Montgomery, Heli Nevanlinna, Ilja M Nolte, Dale R Nyholt, Nadia Obi, Katie M O'Brien, Kenneth Offit, Albertine J Oldehinkel, Sisse R Ostrowski, Aarno Palotie, Ole B Pedersen, Annette Peters, Giulia Pianigiani, Dijana Plaseska-Karanfilska, Anneli Pouta, Alfred Pozarickij, Paolo Radice, Gad Rennert, Frits R Rosendaal, Daniela Ruggiero, Emmanouil Saloustros, Dale P Sandler, Sabine Schipf, Carsten O Schmidt, Marjanka K Schmidt, Kerrin Small, Beatrice Spedicati, Meir Stampfer, Jennifer Stone, Rulla M Tamimi, Lauren R Teras, Emmi Tikkanen, Constance Turman, Celine M Vachon, Qin Wang, Robert Winqvist, Alicja Wolk, Babette S Zemel, Wei Zheng, Ko W Van Dijk, Behrooz Z Alizadeh, Stefania Bandinelli, Eric Boerwinkle, Dorret I Boomsma, Marina Ciullo, Georgia Chenevix-Trench, Francesco Cucca, Tõnu Esko, Christian Gieger, Struan F A Grant, Vilmundur Gudnason, Caroline Hayward, Ivana Kolčić, Peter Kraft, Deborah A Lawlor, Nicholas G Martin, Ellen A Nøhr, Nancy L Pedersen, Craig E Pennell, Paul M Ridker, Antonietta Robino, Harold Snieder, Ulla Sovio, Tim D Spector, Doris Stöckl, Cathie Sudlow, Nic J Timpson, Daniela Toniolo, André Uitterlinden, Sheila Ulivi, Henry Völzke, Nicholas J Wareham, Elisabeth Widen, James F Wilson, Lifelines Cohort Study, Danish Blood Donor Study, Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, Biobank Japan Project, China Kadoorie Biobank Collaborative Group, Paul D P Pharoah, Liming Li, Douglas F Easton, Pål R Njølstad, Patrick Sulem, Joanne M Murabito, Anna Murray, Despoina Manousaki, Anders Juul, Christian Erikstrup, Kari Stefansson, Momoko Horikoshi, Zhengming Chen, I Sadaf Farooqi, Nelly Pitteloud, Stefan Johansson, Felix R Day, John R B Perry, Ken K Ong

Faculty, Staff and Student Publications

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respectively. We identified several genes harboring rare loss-of-function variants in ~200,000 women, including variants in ZNF483, which abolished the impact of polygenic risk. Variant-to-gene mapping approaches and mouse gonadotropin-releasing hormone neuron RNA sequencing implicated 665 genes, including an uncharacterized G-protein-coupled receptor, GPR83, …


The Impact Of Ribosome Biogenesis In Cancer: From Proliferation To Metastasis, Nitish Mittal, Faisal S Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas Davee, Nirav Thosani, Vaibhav Wadhwa Jul 2024

The Impact Of Ribosome Biogenesis In Cancer: From Proliferation To Metastasis, Nitish Mittal, Faisal S Ali, Antonio Pizuorno Machado, Sean Ngo, Malek Shatila, Tomas Davee, Nirav Thosani, Vaibhav Wadhwa

Faculty, Staff and Student Publications

A proportion of patients who undergo intraoperative cholangiogram (IOC) do not have bile duct stones at the time of endoscopic retrograde cholangiopancreatography (ERCP), either due to the spontaneous passage of stones or a false-positive IOC. Glucagon has been utilized as an inexpensive tool to allow the passage of micro-choledocholithiasis to the duodenum and resolve filling defects caused by stones or air bubbles. The purpose of our study is to understand the change in diagnostic accuracy of IOC to detect choledocholithiasis with intraoperative glucagon. We conducted a retrospective study at a tertiary care center on adult patients who underwent laparoscopic cholecystectomy …


Personal Light Exposure Patterns And Incidence Of Type 2 Diabetes: Analysis Of 13 Million Hours Of Light Sensor Data And 670,000 Person-Years Of Prospective Observation, Daniel P Windred, Angus C Burns, Martin K Rutter, Chris Ho Ching Yeung, Jacqueline M Lane, Qian Xiao, Richa Saxena, Sean W Cain, Andrew J K Phillips Jul 2024

Personal Light Exposure Patterns And Incidence Of Type 2 Diabetes: Analysis Of 13 Million Hours Of Light Sensor Data And 670,000 Person-Years Of Prospective Observation, Daniel P Windred, Angus C Burns, Martin K Rutter, Chris Ho Ching Yeung, Jacqueline M Lane, Qian Xiao, Richa Saxena, Sean W Cain, Andrew J K Phillips

Faculty, Staff and Student Publications

BACKGROUND: Light at night disrupts circadian rhythms, and circadian disruption is a risk factor for type 2 diabetes. Whether personal light exposure predicts diabetes risk has not been demonstrated in a large prospective cohort. We therefore assessed whether personal light exposure patterns predicted risk of incident type 2 diabetes in UK Biobank participants, using ∼13 million hours of light sensor data.

METHODS: Participants (N = 84,790, age (M ± SD) = 62.3 ± 7.9 years, 58% female) wore light sensors for one week, recording day and night light exposure. Circadian amplitude and phase were modeled from weekly light data. Incident …


The Aridification Of The Great Salt Lake, David Thompson Jul 2024

The Aridification Of The Great Salt Lake, David Thompson

Ballard Brief

Throughout Nepal, brick kilns employ thousands of families annually for the seasonal work of crafting and shipping bricks. As families migrate between work in brick factories and agricultural work at home, more factors block their children from a complete and quality education. The open invitation to begin working with their parents and to help provide for the family becomes a strong temptation that causes many children to give up on school. In addition, Nepal's lack of law enforcement frequently allows children to drop out of school early without consequence. Their parents do not attempt to stop them either, making little …


Building School Culture Improves Students’ Mental Health, Katie Henrichs Jul 2024

Building School Culture Improves Students’ Mental Health, Katie Henrichs

Master's Theses & Capstone Projects

Students are experiencing a rise in mental health challenges, which can have a negative impact on academic performance, lead to an increase in undesirable behaviors, and result in attendance issues. Research shows that creating a positive school community can contribute to the well-being of students. A school improvement plan has been developed to foster a sense of community at Loess Hills. Both students and staff will be involved in surveys, focus groups, and the inclusion of a social-emotional curriculum. Promoting a positive culture where students can thrive can be achieved by raising awareness and providing support for young people dealing …


Report On Findings From Household Needs Study, Paulin T. Straughan, Mathew Mathews Jul 2024

Report On Findings From Household Needs Study, Paulin T. Straughan, Mathew Mathews

ROSA Research Briefs

The Household Needs Study (HNS) aimed to capture public perspectives on essential items and activities that are deemed necessary for a normal life in Singapore and to understand the extent to which Singaporeans are able to access these items and activities. To do so, the study adopted the Living Standards Approach (Saunders, Naidoo & Wong, 2022), which purports that individuals experience relative deprivation and/or social exclusion if they do not have access to items and activities that are deemed to be essential by society. In this study, a survey was conducted with a nationally representative sample of around 4,000 respondents …


Bracketed Assessments In Behavioral Gerontology: Evaluating Preference With Present And Absent Stimuli, Flavia Eduarda Del Castillo Troche Jul 2024

Bracketed Assessments In Behavioral Gerontology: Evaluating Preference With Present And Absent Stimuli, Flavia Eduarda Del Castillo Troche

Theses and Dissertations

The present study evaluated the use of bracketed assessments to assess the activity preference of three individuals with dementia. The study proposed an alternative method to traditional stimulus preference assessments, to bridge the gap in behavior analytical literature within behavioral gerontology. Thus, bracketed assessments were conducted using two presentation methods, verbal plus visual presentation and verbal-only presentation. Results suggested that while participants showed consistency within low preferred activity selection in the bracketed assessment, variability was observed among participants’ preferences for high and moderate preferred activities. Both presentation methods yield similar selection results for one participant, however, the other two participants …


Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman Jul 2024

Impact Of Non-Thermal Plasma Generated Using Air And Nitrogen On Functional Properties Of Milk Protein Dispersions, Nikitha Modupalli, Md Mahfuzur Rahman

Food Science Faculty Publications and Presentations

This study focuses on improving the functionalities of milk protein concentrate (MPC) using a nonthermal plasma jet and plasma-activated water (PAW) with atmospheric air and nitrogen as source gases. The 5% and 10% MPC dispersions were directly treated with a plasma jet, and PAW was used to make the MPC dispersions. The dispersions were analyzed for changes in protein structure and functional properties. The treatment altered the secondary structure of MPC protein structure by increasing β-components and changing the order of random coils. The solubility of the PAW-treated 5% protein dispersions doubled due to plasma-induced modification of hydrophilic and covalent …