Digital Commons Network^™

Navigating The Complexity Of Applying Nutrition Evidence To Individualised Care: Summary Of An Academy Of Nutrition Sciences Position Paper, Judith Buttriss, Mary Hickson, Kevin Whelan, Christine Williams

School of Health Professions

Diet is key to the maintenance of health and crucial in the prevention and management of many diseases. Modified nutrient intake may become essential to prevent deficiency, optimise development and health or manage symptoms and disease progression. Adding to the complexity, disease and its treatment can also affect taste, appetite and ability to access and prepare foods. Coupled with this, individual requirements for energy, macronutrients and micronutrients are influenced by factors such as life stage (age, growth, pregnancy, etc.) and health status, which can affect the processes of consuming, digesting, absorbing, metabolising or excreting nutrients. First and foremost, dietary advice …

Guide To The Alan Bersin Papers, Alan Douglas Bersin

Special Collections

The Alan Bersin papers consist of records collected by Bersin during his tenure as the Superintendent of San Diego City Schools and the Secretary of Education for the State of California. The vast majority of the records are in the form of correspondence, memoranda, meeting minutes, reports, and newspaper articles. These records delve into the workings of Bersin's office, planning behind such programs as the Blueprint for Student Success, the Institute for Learning, Special Education, and Charter Schools. Correspondence, news articles, and court cases document reaction to those programs from the public, labor unions, and the San Diego Board of …

Investigation Of The Ecological Interactions And Host Specificity Of Verticillium Nonalfalfae, A Proposed Biological Control Agent Against The Invasive Tree-Of-Heaven (Ailanthus Altissima), Kristen H. Pierce

Graduate Theses, Dissertations, and Problem Reports (ETD)

Tree-of-heaven (Ailanthus altissima) is a highly invasive tree species with a cosmopolitan distribution, including an expansive range in North America. In the U.S., tree-of-heaven has established populations in more than 40 states and is considered among the most notorious of invasive plant species. The discovery of Verticillium nonalfalfae and V. dahliae causing acute wilt and mortality of Ailanthus in the mid-Atlantic in the 2000s has resulted in numerous studies evaluating the utility of these fungi as potential biocontrol agents. Recent efforts to commercialize V. nonalfalfae have raised additional questions about its widespread use and factors influencing long-term efficacy. …

Implementation Of A Diabetes Mellitus Self-Management Program, Rebecca Johnston

DNP Projects

Type 2 diabetes is prevalent nationwide, increasing the risk of various complications including heart disease, stroke, kidney failure, blindness, and amputations. The literature review highlights a potential correlation between inadequate education and a lack of control of glucose in individuals diagnosed with Type 2 Diabetes Mellitus. The purpose of this Doctor of Nursing Practice (DNP) quality improvement project was to improve knowledge of Diabetes Type 2 self-management, in turn improving the outcomes of patients who were newly diagnosed with Type 2 Diabetes Mellitus and patients who had a Hemoglobin A1c >7%, as well as management of weight in these patients. …

The Need For More Inclusive Deliberation On Ethics And Governance In Agricultural And Food Biotechnology, Catherine Kendig, Theresa Selfa, Paul B. Thompson, Raymond Anthony, Wenda Bauchspies, Gwendolyn Blue, Ashmita Das, Rebecca Harrison, Chris Henke, Shan Jin, Jennifer Kuzma, Forbes Lipschitz, Kurt Lichter, Morgan Ruelle, Timothy Silberg, Bruno Takahashi

Sustainability and Social Justice

An inclusive and socially legitimate governance structure is absent to address concerns over new agricultural biotechnologies. Establishing an agricultural bioethics commission devoted to inclusive deliberation on ethics and governance in agricultural and food biotechnology is urgent. Highlighting the social and ethical dimensions of current agricultural bioengineering disputes in the food system, we discuss how a nationally recognized policy forum could improve decision-making and increase public understanding of the issues. We clarify ways the concepts that are used to categorize food and frame governance of food affect consumer choices, and how dissemination of information and the mode of dissemination can contribute …

Metabolink Is A Novel Algorithm For Unveiling Cell-Specific Metabolic Pathways In Longitudinal Datasets, Jared Lichtarge, Gerarda Cappuccio, Soumya Pati, Alfred Kwabena Dei-Ampeh, Senghong Sing, Lihua Ma, Zhandong Liu, Mirjana Maletic-Savatic

Duncan NRI Faculty and Staff Publications

Introduction: In the rapidly advancing field of 'omics research, there is an increasing demand for sophisticated bioinformatic tools to enable efficient and consistent data analysis. As biological datasets, particularly metabolomics, become larger and more complex, innovative strategies are essential for deciphering the intricate molecular and cellular networks.

Methods: We introduce a pioneering analytical approach that combines Principal Component Analysis (PCA) with Graphical Lasso (GLASSO). This method is designed to reduce the dimensionality of large datasets while preserving significant variance. For the first time, we applied the PCA-GLASSO algorithm (i.e., MetaboLINK) to metabolomics data derived from Nuclear Magnetic Resonance (NMR) spectroscopy …

Exploring The Impact Of Early Adversity On Young Children With Autism, Kelsea M. Batista

Antioch University Dissertations & Theses

This dissertation builds on a small but growing literature exploring the association between early adverse childhood experiences (ACEs) and children diagnosed with autism spectrum disorder (ASD). Research suggests that children with ASD are more likely to experience ACEs throughout their lifetime due to increased vulnerability to victimization and social communication deficits. Still, to date, there is scant research explicitly exploring the impact of ACEs on young children diagnosed with ASD. This study utilized a biopsychosocial framework to further examine whether a relationship exists between ACEs and ASD. The objectives of this study include: (a) to determine whether a relationship exists …

The Legal Framework For The Protection Of Victims Of The Worst Forms Of Child Labour In Agriculture In Ghana: A Human Rights Based Approach, Ruby Akua Aglagoh

Theses: Doctorates and Masters

Child labour is prevalent in Ghana, especially in the agriculture industry where children engage in work that is harmful to their health, morals, and safety. Such harmful work has been defined by the ILO Convention No. 182 on the Worst Forms of Child Labour, 1999 as constituting the worst forms of child labour. These children have human rights stated in the laws of Ghana but have become victims of human rights violations because they cannot access the protections provided for under the international conventions and national laws of Ghana.

Using doctrinal legal research, this thesis reviews the legal framework of …

Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill

Faculty, Staff and Student Publications

Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …

Understanding Primary Care Physician Perspectives On The Diagnosis And Management Of Non-Alcoholic Fatty Liver Disease: A Qualitative Study, Natalia I Heredia, Jemima C John, Sonia Singh, Jessica P Hwang, Larkin L Strong, Maya Balakrishnan, Lorna H Mcneill

Faculty, Staff and Student Publications

Primary care physicians (PCPs) are well suited to manage patients with non-alcoholic fatty liver disease (NAFLD), but the limited, existing research suggests inadequate knowledge about the natural history, diagnostic methods, and management of NAFLD. The purpose of this qualitative study is to further understand the knowledge and practices for the diagnosis and management of NAFLD among PCPs. We conducted in-depth interviews with PCPs in the Greater Houston area, addressing current clinical practices used for diagnosing and managing NAFLD, as well as the perceptions of the PCPs regarding the burden of NAFLD on patients. We recorded interviews, transcribed them, coded transcripts, …

Disability, Race, And Health Beyond The Carceral State, Benjamin Barsky, Craig Konnoth, Michael A. Stein

Faculty Scholarship

No abstract provided.

Association Of Circulating Ketone Bodies With Cognitive Performance And Dementia In The Multi-Ethnic Study Of Atherosclerosis (Mesa), Parag Anilkumar Chevli, Christopher L Schaich, Alexis C Wood, Luqman A Tk, Anurag Mehta, Vardhmaan Jain, Margery Connelly, Suzanne Craft, Elad Shemesh, José A Luchsinger, Kathleen M Hayden, Bonnie Colleen Sachs, Timothy M Hughes, Michael D Shapiro

Faculty, Staff and Students Publications

Introduction

Growing interest centers on the association between circulating ketone bodies (KB) and cognitive function, notably in aging and neurodegenerative diseases.

Methods

Associations of plasma KB with incident dementia and cognitive performances were examined among Multi‐Ethnic Study of Atherosclerosis (MESA) participants. KB were measured using plasma samples collected following an overnight fasting at Exam 1 (2000–02) and detailed cognitive testing at Exam 5 (2010–2012, N = 4392), Exam 6 (2016–2018, N = 1838), and in MESA‐MIND (2019–2021, N = 2060).

Results

Over 16.7 years, a doubling of total KB was associated with a greater risk of incident dementia (hazard ratio …

Fluoxetine And Sertraline Inhibit Height Growth And Growth Hormone Signaling During Puberty, Chadi Calarge, Chima Amushie, Stephanie Dinh, James A Mills, Sridevi Devaraj, Griselda Barba-Villalobos, Jacqueline Nguyen, Jose M Garcia, Stephanie Sisley, Fida Bacha, Babette Zemel

Faculty, Staff and Students Publications

Purpose: The aim of this study was to examine the effect of fluoxetine and sertraline on height growth and insulin-like growth factor-1 (IGF-1) during puberty.

Methods: In this 6-month cohort study, electronic medical records were used to identify 8- to 15-year-old participants, within 1 month of starting fluoxetine (n = 39) or sertraline (n = 27), and sexual maturation stages 2 to 4 were confirmed. Conditions that interfere with height growth led to exclusion. Participants underwent anthropometric assessments and phlebotomy. Healthy, unmedicated children (n = 36) also provided anthropometric data.

Results: After the baseline height Z-score, sex, Tanner stage, daily …

The Impact Of Obesity-Associated Glycine Deficiency On The Elimination Of Endogenous And Exogenous Metabolites Via The Glycine Conjugation Pathway, Hong Chang Tan, Jean W Hsu, E Shyong Tai, Shaji Chacko, Jean-Paul Kovalik, Farook Jahoor

Faculty, Staff and Students Publications

BACKGROUND: Glycine is an integral component of the human detoxification system as it reacts with potentially toxic exogenous and endogenously produced compounds and metabolites via the glycine conjugation pathway for urinary excretion. Because individuals with obesity have reduced glycine availability, this detoxification pathway may be compromised. However, it should be restored after bariatric surgery because of increased glycine production.

OBJECTIVE: To examine the impact of obesity-associated glycine deficiency on the glycine conjugation pathway. We hypothesize that the synthesis rates of acylglycines from endogenous and exogenous sources are significantly reduced in individuals with obesity but increase after bariatric surgery.

METHODS: We …

Moab Local Food Guide 2024, Roslynn Mccann, Shiree Duncan

All Current Publications

Thank you for picking up this Moab Utah Local Food Guide. Those growing and producing food within a 100 mile radius from Moab have been included in this guide to help YOU make locally sourced purchasing decisions!

Newborn Screening Analytes And Structural Birth Defects Among 27,000 Newborns, Philip J Lupo, Natalie P Archer, Rachel D Harris, Lisa K Marengo, Jeremy M Schraw, Adrienne T Hoyt, Susan Tanksley, Rachel Lee, Margaret Drummond-Borg, Debra Freedenberg, Priya B Shetty, A J Agopian, Charles Shumate, Sonja A Rasmussen, Peter H Langlois, Mark A Canfield

Center for Medical Ethics and Health Policy Staff Publications

Background: Emerging evidence suggests newborn screening analytes may yield insights into the etiologies of birth defects, yet no effort has evaluated associations between a range of newborn screening analytes and birth defects.

Methods: This population-based study pooled statewide data on birth defects, birth certificates, and newborn screening analytes from Texas occurring between January 1, 2007 and December 31, 2009. Associations between a panel of thirty-six newborn screening analytes, collected by the statewide Texas Newborn Screening Program, and the presence of a birth defect, defined as at least one of 39 birth defects diagnoses recorded by the Texas Birth Defects Registry, …

Investigation Of Setmelanotide, An Mc4r Agonist, For Obesity In Individuals With Smith-Magenis Syndrome, Julia Lazareva, Stephanie R Sisley, Sheila M Brady, Ann C M Smith, Sarah H Elsea, Jeremy J Pomeroy, Christian L Roth, Jennifer E Sprague, Martin Wabitsch, Jill Garrison, Jack A Yanovski

Children’s Nutrition Research Center Staff Publications

Background: Smith Magenis Syndrome (SMS) is a rare genetic disorder caused by RAI1 haploinsufficiency. Obesity in people with SMS is believed partially due to dysfunction of the proximal melanocortin 4 receptor (MC4R) pathway. We therefore studied effects of treatment with the MC4R agonist setmelanotide on obesity and hunger, as well as metabolic, cardiac and safety, in individuals with SMS.

Methods: People with SMS received once-daily setmelanotide injections, with the dose titrated bi-weekly to a maximum of 3 mg over ∼1 month; and a full-dose treatment duration of 3mo. The primary outcome was percent change in body weight. Secondary outcomes included …

Racial And Ethnic Disparities In Hospital Practices That Support Breastfeeding In The United States, Jane Lazar Tucker

Open Access Dissertations

Breastfeeding is the optimal form of infant nutrition and has many health benefits for mothers as well as infants (CDC, 2022a; Victora et al., 2016). Though rates of breastfeeding have improved in recent years, disparities in breastfeeding persist among Black and Hispanic women compared to White women (Beauregard et al., 2019; Chiang et al., 2021), despite similar intentions to breastfeed across all racial/ethnic groups (Hamner et al., 2021). Hospital practices that support breastfeeding, such as the baby being placed skin-to-skin immediately after delivery or staying in the room with the mother throughout the hospital stay, are known to predict breastfeeding …

Effects Of Western Diet Or Exercise Exposure In A Novel Rat Model Of Late-Onset Alzheimer’S Disease, Jennifer M. Mattar

Open Access Dissertations

Sporadic, late-onset Alzheimer’s disease (LOAD) accounts for a staggering 98% of cases yet does not arise from a single genetic mutation. Rather, an extensive body of research has revealed that LOAD is likely the result of complex interactions between genetics and several lifestyle factors. There exists a substantial gap in understanding the mechanisms behind LOAD development and the impacts of lifestyle on disease progression. Enhanced rodent models may help elucidate mechanisms by which LOAD develops. This longitudinal study introduces a novel rat model of LOAD (CrAβ), created using CRISPR-Cas9 gene editing technology to express humanized Aβ. The effects of a …

Implementation And Evaluation Of A Nutriton-Focused Steam Summer Program For Urban Youth, Jacquelyn Potvin

Open Access Dissertations

Background: Youth from low-income, racially and ethnically diverse families are at increased risk for academic challenges and nutritionally inadequate diets. Summer programs offer an opportunity to foster interest and engage students in science, technology, engineering, art, and math (STEAM) education while addressing summer learning loss. Nutrition education early in life can help youth develop healthy dietary behaviors that they carry into adulthood. Project stRIde: Science and Technology Reinforced by Innovative Dietary Education was a summer program for 4-6th grade youth from racially and ethnically diverse and low-income families. The goal of the program was to engage youth in nutrition-centered …

Mechanistic And Toxicokinetic Analysis Of Perfluoroalkyl Substances: Proteomics Approach And The Role Of Fatty Acid Binding (Fabp), Seyed Mohamad Sadegh Modaresi

Open Access Dissertations

Per- and polyfluoroalkyl substances (PFAS) are persistent chemicals used in many industries, known for their resilience and resistance to degradation. The extended half-lives of PFAS in the human body result in bioaccumulation, with serum half-lives for perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS) estimated at 3.4, 4.6, and 7.1 years, respectively. PFAS primarily accumulate in the liver, hypothesized due to their resemblance to fatty acids and their binding with liver fatty acid-binding proteins (LFABP), affecting lipid metabolism and leading to liver toxicity. Although extensive research has been performed on long-chain PFAS over the past decade, …

Advancing Clinical-Community Partnerships To Address Pediatric Food Insecurity, Nader Hamdi

Open Access Dissertations

Background: Children and families experiencing low income in the United States are at a greater risk of food insecurity (FI) and suboptimal diet quality than the general population. Childhood FI, which is associated with numerous poor health and developmental outcomes, has become so pervasive that the American Academy of Pediatrics recommends universal FI screenings. Routine FI screening in clinical settings presents opportunities for clinic-community partnerships to connect families experiencing FI with food access and nutrition education (FANE) programs. A variety of FANE programs, including the Supplemental Nutrition Assistance Program - Education (SNAP-Ed), are administered at the federal level to …

Learning From The Past: Environmental Impacts On Coral Performance, Reproduction, And Epigenetic Inheritance, Danielle M. Becker

Open Access Dissertations

Coral reef ecosystems face extreme challenges due to increasing ocean temperatures caused by anthropogenically induced global climate change and require reproductive replenishment for reef persistence. Corals and other marine invertebrates have exhibited the capacity for environmental memory, or the retention of information from prior environmental experiences, which can be inherited by subsequent generations (e.g., via non-genetic mechanisms). However, less is known about how molecular modifications in the coral epigenome influence acclimatization and adaptive responses to environmental variation within and across generations. Here, I present three manuscripts testing different mechanisms involved in coral’s physiological, reproductive, and epigenetic response to environmental perturbation …

Incomplete Streets, Michael Lewyn

Scholarly Works

Over 1700 complete streets policies have been adopted by state and local government; these policies typically provide that streets shall be designed to benefit all users, not just motorists. This article analyzes some complete streets policies, and concludes that even above-average policies are often too vague and underfunded to significantly change the status quo. The article suggests a variety of reforms that might make complete streets policies more effective.

Development, Usability, And Preliminary Efficacy Of A Virtual Reality Experience To Promote Healthy Lifestyle Behaviors In Children: Pilot Randomized Controlled Trial, Lauren A. Fowler, Melissa M. Vázquez, Bianca Depietro, Denise E. Wilfley, Ellen E. Fitzsimmons-Craft

2020-Current year OA Pubs

BACKGROUND: Virtual reality (VR) shows promise for supporting behavior change in children. This study used user-centered design to translate key tenets of behavioral health interventions into VR for children aged 6-12 years and their caregivers and examined the feasibility, acceptability, and preliminary efficacy of the VR experience in a pilot parallel, two-group randomized controlled trial (RCT).

METHODS: The VR experience incorporates psychoeducational content from evidence-based behavioral health interventions using voiceover and an interactive go-kart game related to the concepts of "food as fuel" and nutrition guidelines. Study 1 involved usability testing with n=5 child-caregiver dyads, which informed technical and content …

The Neurochemistry Of Depression: The Good, The Bad And The Ugly, Kami Pearson, Kimberley Beier, Thornton Mardis, Bryan Munoz, Asma Zaidi

Faculty and Staff Publications

A large constellation of experimental evidence suggests that neuroinflammation is involved in the onset of depression and neurodegenerative disorders. Many studies have shown impairments in tryptophan metabolism, the major pathway for the synthesis of serotonin, the mood regulating neurotransmitter. This article reviews the various metabolites generated in the competing pathways of tryptophan metabolism including the kynurenine pathway. Increased synthesis of the neurotoxic compound quinolinic acid occurs at the expense of the synthesis of the neuroprotective metabolite kynurenic acid. This shift in equilibrium plays a critical role in the induction of oxidative stress, neuroinflammation, and neurotoxicity. Sufficient protein intake with adequate …

Blunt Speech Rights, Nicholas Almendares

Articles by Maurer Faculty

There is a lot to be said about the Supreme Court’s decision in 303 Creative LLC. In the wake of the decision there will be a range of commentaries like those presented in this Issue. I want to draw attention to a particular aspect of the opinion, part of a broader trend in the Court’s First Amendment jurisprudence, towards blunt, sweeping rules. By a blunt rule, I mean a simple, coarse one that lacks nuance or distinctions. Blunt rules, by their nature, tend to be sweeping: nuance, that is, distinguishing cases based on various factors, limits the scope of a …

Development Of An Order Set To Improve Consistency Of Blood Glucose Monitoring For Hospitalized Patients On Enteral Feeding, Kristen Calebaugh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of an Order set to Improve Consistency of Blood Glucose Monitoring for Adult Hospitalized Patients on Enteral Feeding

Kristen Calebaugh, BSN, RN

Background

Hospitalized patients often require artificial nutrition through either enteral feeding, placing the patient at risk for glucose alterations related to physiological responses of nutritional metabolism. Historically, there has been no standard of care or consistency aligning tube feedings times with point of care blood glucose testing. Without a standardized order set to guide blood glucose monitoring orders, patients on artificial nutrition may experience undetected hypo or hyperglycemia or inadequate glycemic control, which can cause adverse …

Polylactic Acid (Pla) Containing Talc Microparticles And Amorphous Polyhydroxyalkanoates (Aphas) For Improved Barrier And Mechanical Properties In Food Packaging, Mohammed Alfaifi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Polylactic acid (PLA) is a biobased and compostable polymer that is increasingly being used as an alternative to petroleum-based, non-biodegradable polymers for single-use food packaging due to its environmental benefits. It is also commercially available in large quantities, and it can be processed like polyethylene. However, it has a higher water-vapor permeability (WVP) as compared to polyolefins and polyethylene terephthalate that are the incumbent materials. This results in a competitive disadvantage in employing PLA for packaging baked goods since the shelf life of the food is likely to be reduced. In the past, barrier properties of PLA were improved by …

The Intellectual Structure Of Audit Committee Research: A Bibliometric Analysis (1969 – 2020), Joel Behrend, Marc Eulerich, David A. Wood

Faculty Publications

The audit committee is a widely recognized mechanism of effective corporate governance. We advance prior literature reviews by using bibliometric analysis techniques that comprehensively process large bodies of bibliometric information. We base inferences on citation patterns of 1,173 articles to identify concepts that “shine through” within the scientific understanding of audit committees. Using content analysis, we then analyze these concepts and explore existing interrelationships. We document a declining influence of audit committee research, as well as a widening gap between the quantitative and qualitative research camps. While the former is mostly derivative in nature, the latter produces innovative insights on …