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2024

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Composite Hedonic Scores And Subjective Palatability Ratings In Young Adults Consuming Three Breakfast Meals Differing By Level Of Food Processing And Nutritional Quality, Ilayna Seibold Jan 2024

Composite Hedonic Scores And Subjective Palatability Ratings In Young Adults Consuming Three Breakfast Meals Differing By Level Of Food Processing And Nutritional Quality, Ilayna Seibold

Open Access Master's Theses

Objective: To compare subjective palatability ratings across three meals differing by processing and nutritional quality (NQ) in healthy young adults. The aim was to match meals for subjective palatability in preparation for a larger crossover study. As such, an interim analysis was planned to determine if the meals were tracking towards similar ratings or not.

Methods: In this within-subjects individualized-testing study, 30 consented participants reported demographics. They each came for one 1-hour lab visit to sample three matched (flavor profiles, macronutrients, energy) test meals differing by processing and NQ: Low Ultra-Processed food (UPF)/High NQ (Meal 1), High UPF/High …


Associations Between Fatty Acid Status And Postpartum Depressive Symptoms In Ghanaian Women At 6 Months Postpartum: A Secondary Data Analysis, Kelly L. Zarka Jan 2024

Associations Between Fatty Acid Status And Postpartum Depressive Symptoms In Ghanaian Women At 6 Months Postpartum: A Secondary Data Analysis, Kelly L. Zarka

Open Access Master's Theses

Introduction: Postpartum depression (PPD) affects 10-20% of women globally and has a negative impact on maternal and infant health. Omega-3 fatty acids have been implicated in psychiatric health due to their anti-inflammatory properties, contrasting with the proinflammatory effects of omega-6 fatty acids. Within Ghana, 2% of an estimated 2.3 million people are living with mental illness and are not seeking treatment due to poor attitudes surrounding mental health. We do not fully understand the risk factors associated with the development of PPD, and therefore how to inform pro-grams seeking to make positive reforms in this area.

Methods: This …


Carotenoids And The Associations With Gut Microbiota Bacterial Populations In Chronic Kidney Disease Hemodialysis Patients, Andrea Kendall Jan 2024

Carotenoids And The Associations With Gut Microbiota Bacterial Populations In Chronic Kidney Disease Hemodialysis Patients, Andrea Kendall

Theses and Dissertations

Background: With increased prevalence and mortality of chronic kidney disease (CKD), treatment by renal replacement therapy using hemodialysis (HD) has increased in parallel. Emerging evidence suggests that gut microbiota play an important role in the progression of CKD; influential dietary factors have not been studied exhaustively to date.

Objective: To explore the relationships between dietary carotenoid intake, the abundance of specific gut microbiota, and symptom-related outcomes in patients with CKD on HD.

Methods: This cross-sectional study investigated the gut microbiota characteristics relative to carotenoid intake in CKD subjects on HD in central Illinois (n = 20). The Block Dialysis …


Associations Between Physical Activity And Academic Achievement In Young Adolescents, Alex Wolfe Jan 2024

Associations Between Physical Activity And Academic Achievement In Young Adolescents, Alex Wolfe

Theses and Dissertations

This study examined the associations between physical activity and academic achievement among young adolescents. A secondary aim of this study was to analyze differences in physical activity and academic achievement by SES and race/ethnicity. The sample consisted of 30 middle school students (10 boys and 20 girls) between the ages of 11.0- and 14.9-years. Partial correlation coefficients were calculated to examine the relationship between physical activity and academic achievement while controlling for SES and race/ethnicity. 2 x 2 factorial analysis of covariance were utilized to examine the differences in SES and race/ethnicity groups, as well as interactive effects within physical …


The Freshman Life And Student Health (Flash) Study: Using Social Network Analysis To Understand How Obesity And Stigma Impact Emerging Adult Health, Alena C. Borgatti Jan 2024

The Freshman Life And Student Health (Flash) Study: Using Social Network Analysis To Understand How Obesity And Stigma Impact Emerging Adult Health, Alena C. Borgatti

All ETDs from UAB

Both racial discrimination and weight stigma have been identified as risk factors for poorer mental, physical, and social health. College students are vulnerable to the effects of stigma, as they greatly value peer acceptance and friendships during a pivotal time of emotional and health behavior development. The present study was the first to use social network analysis to examine the impact of weight and racial discrimination on the development of college social relationships and how these experiences influence students’ physical and mental health. 1330 participants (69% of on-campus freshmen) completed a brief survey on social networks, physical health, mental health, …


Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth Jan 2024

Response Of Helenium Amarum To Environmental Stressors In The Presence Of Mycorrhizal Fungi And Its Role As A Pollinator Resource, Austin Jameson, Lisa Horth

Biological Sciences Faculty Publications

Globally, climate change is causing shifts in precipitation patterns. Shifting precipitation patterns can be a stressor for many species. One species that is experiencing such stress is Helenium amarum Raf (H. Rock). H. amarum, thrives in dry upland pastures and low-lying grassy and sandy habitat in the mid-Atlantic (USA), where it persists despite storm-driven standing water. Helenium amarum is a species that is toxic to livestock and has been found outside its native range. Temperature and light impacts on germination are already known, but the role of water availability and potential ameliorating effects of mycorrhizae during water stress have …


Tree Species Richness And Ash Density Have Variable Effects On Emerald Ash Borer Biological Control By Woodpeckers And Parasitoid Wasps In Post-Invasion White Ash Stands, Caleb J. Wilson, Toby R. Petrice, Therese M. Poland, Deborah G. Mccullough Jan 2024

Tree Species Richness And Ash Density Have Variable Effects On Emerald Ash Borer Biological Control By Woodpeckers And Parasitoid Wasps In Post-Invasion White Ash Stands, Caleb J. Wilson, Toby R. Petrice, Therese M. Poland, Deborah G. Mccullough

Entomology Faculty Publications

Emerald ash borer (EAB) (Agrilus planipennis Fairmaire) (Coleoptera: Buprestidae) is the most destructive insect to invade North American forests. Identifying habitat features that support EAB natural enemies is necessary to enhance EAB biological control. In many forest ecosystems, tree species diversity has been linked with reduced pest abundance and increases in natural enemy abundance. We assessed the influence of tree species richness, ash density, and proportion of total ash basal area on ash canopy condition, EAB larval densities, and biocontrol by woodpeckers and parasitoids in pairs of healthy and declining overstory (DBH > 10 cm) and recruit-sized ash (DBH 2–10 cm) …


Increasing Type 2 Diabetes Mellitus Self-Efficacy In A Rural Primary Care Clinic Using Telehealth Education, Courtney Mccarty Jan 2024

Increasing Type 2 Diabetes Mellitus Self-Efficacy In A Rural Primary Care Clinic Using Telehealth Education, Courtney Mccarty

Doctor of Nursing Practice (DNP)

Type 2 diabetes mellitus is a chronic disease that causes a burden to people with the illness, to their families, and to the healthcare system worldwide. It is a preventable noncommunicable disease that causes significant economic global impacts, especially in areas of rurality and low socioeconomic status. Despite its prevalence in the United States, type 2 diabetes mellitus still poses increased rates of complications and mortality due to ineffective management, improper skills, and lack of knowledge to care for oneself. In addition, this population often lacks self-efficacy or the belief that they can manage and perform tasks to promote desired …


Implementing A Donor Human Milk Protocol To Improve Exclusive Breastfeeding Rates, Theresa Davis Jan 2024

Implementing A Donor Human Milk Protocol To Improve Exclusive Breastfeeding Rates, Theresa Davis

Doctor of Nursing Practice (DNP)

Exclusive breastfeeding is a metric that hospitals nationwide work to improve. It is recommended that newborns breastfeed exclusively for at least the first six months to one year. There are several long-term health benefits and impacts for the new mother-baby couplet. Although touted as the most natural way to feed your baby, it is not always easy. Prenatal breastfeeding intention and education are associated with increased rates of exclusivity and duration. The breastfeeding journey is a process unique to the couplet experiencing it. Worldwide, the rates of newborns who exclusively breastfeed are below the World Health Assembly’s 2030 target of …


Implementing A Preventive Reproductive Screening And Intervention Program In A Primary Care Clinic To Improve Women’S Health During The Preconception Period, Wienelmine Estime-Joiner Jan 2024

Implementing A Preventive Reproductive Screening And Intervention Program In A Primary Care Clinic To Improve Women’S Health During The Preconception Period, Wienelmine Estime-Joiner

Doctor of Nursing Practice (DNP)

Unintended pregnancy, a significant public health concern in the United States, is linked to poor health outcomes due to inadequate preconception care. This DNP project aimed to enhance preventive reproductive health services for reproductive-age women (ages 18 to 44) in a primary care clinic in metropolitan Atlanta, Georgia. Recognizing the American College of Obstetricians and Gynecologists, American Academy of Primary Care Physicians, Center for Disease Control and Prevention, and Healthy People 2030's recommendations for preventive reproductive screening, and daily folic acid intake pre- pregnancy, the project focused on implementing a reproductive screening tool to assess pregnancy risk, and folic acid …


Lies, Damn Lies, And Privacy Promises, Rash, Andy, Fowler, Leah R. Jan 2024

Lies, Damn Lies, And Privacy Promises, Rash, Andy, Fowler, Leah R.

Santa Clara Law Review

Health apps and other consumer technologies collect massive amounts of sensitive data, including but not limited to information about users’ reproductive lives. As a result, consumer choices—especially for menstruation tracking applications—are at least partly driven by privacy promises in advertising and privacy policies. But there is a problem: whether these promises are grounded in reality can often only be revealed by complex analyses outside the capabilities of the majority of consumers and, even then, may be unknowable in any definitive sense. This essay explores this problem in the context of menstruation tracking applications and post-Dobbs legal developments that implicate reproductive …


Hour Of Life At Enteral Feeding Initiation And Associated Clinical Morbidity In Extremely Low-Birth-Weight Infants, Melissa Thoene, Lauren Ridgway, Elizabeth Lyden, Ann Anderson-Berry Jan 2024

Hour Of Life At Enteral Feeding Initiation And Associated Clinical Morbidity In Extremely Low-Birth-Weight Infants, Melissa Thoene, Lauren Ridgway, Elizabeth Lyden, Ann Anderson-Berry

Journal Articles: Pediatrics

BACKGROUND/OBJECTIVES: Identifying nutritional interventions in extremely low-birth-weight (ELBW) infants (<1000 >g) that are associated with favorable clinical outcomes is important. Delayed enteral feeding initiation (>3 days) has been associated with increased odds of developing morbidity. Therefore, the aim of this study is to evaluate the relationship between hour of life at enteral feeding initiation and associated clinical outcomes.

METHODS: An IRB-approved retrospective chart review evaluated ELBW infants. Birth acuity was evaluated using CRIB II scoring and incidence of various morbidities (bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), necrotizing enterocolitis (NEC), and spontaneous intestinal perforation (SIP)) and mortality was assessed …


Trans Animus, Scott Skinner-Thompson Jan 2024

Trans Animus, Scott Skinner-Thompson

Publications

No abstract provided.


Barring Judicial Review, Laura E. Dolbow Jan 2024

Barring Judicial Review, Laura E. Dolbow

Publications

Whether judicial review is available is one of the most hotly contested issues in administrative law. Recently, laws that prohibit judicial review have sparked debate in the Medicare, immigration, and patent contexts. These debates are continuing in challenges to the recently created Medicare price negotiation program. Yet despite debates about the removal of judicial review, little is known about how often, and in what contexts, Congress has expressly precluded review. This Article provides new insights about express preclusion by conducting an empirical study of the U.S. Code. It creates an original dataset of laws that expressly preclude judicial review of …


Contrasting Species-Specific Stress Response To Environmental Ph Determines The Fate Of Coccolithophores In Future Oceans, Nishant Chauhan, Craig J. Dedman, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Rosalind E.M. Rickaby Jan 2024

Contrasting Species-Specific Stress Response To Environmental Ph Determines The Fate Of Coccolithophores In Future Oceans, Nishant Chauhan, Craig J. Dedman, Chloë Baldreki, Adam A. Dowle, Tony R. Larson, Rosalind E.M. Rickaby

School of Geography, Earth and Environmental Sciences

Molecular mechanisms driving species-specific environmental sensitivity in coccolithophores are unclear but crucial in understanding species selection and adaptation to environmental change. This study examined proteomic and physiological changes in three species under varying pH conditions. We showed that changing pH drives intracellular oxidative stress and changes membrane potential. Upregulation in antioxidant, DNA repair and cell cycle-related protein-groups indicated oxidative damage across high (pH 8.8) and low pH (pH 7.6) compared to control pH (pH 8.2), and correlated with reduced growth rates. Upregulation of mitochondrial proteins suggested higher metabolite demand for restoring cellular homeostasis under pH-induced stress. Photosynthetic rates generally correlated …


Evaluation Of A Student Experiential Learning Clinic For Hand Therapy Using A Logic Model, Rose Mcandrew, Nathaniel Baniqued, Vicki Kaskutas Jan 2024

Evaluation Of A Student Experiential Learning Clinic For Hand Therapy Using A Logic Model, Rose Mcandrew, Nathaniel Baniqued, Vicki Kaskutas

Translational Science in Occupation

Student clinics (SC) provide experiential learning opportunities in occupational therapy (OT) education that develop clinical reasoning, while providing much needed rehabilitation to under and un-insured patients in the community. The Student Experiential Learning Clinic for Hand Therapy (SELC-HT) is a SC that used a logic model for planning, implementing, and evaluating the SELC-HT. The purpose of this study is to report on outcome data on students and patients, as outlined in the evaluation phase of the logic model.

The 13 OT master/doctorate students, who delivered care in the SELC-HT, demonstrated growth in self-reported hand therapy knowledge (p=0.002) measured with …


Mapping Occupational Therapy Interventions In Adult Patients With Post-Covid Diagnosis: A Scoping Review, Jennifer Ng, Hannah Franks, Marissa Halvorson, Sarah Malone, Claudia L. Hilton Phd, Karthik Mani Jan 2024

Mapping Occupational Therapy Interventions In Adult Patients With Post-Covid Diagnosis: A Scoping Review, Jennifer Ng, Hannah Franks, Marissa Halvorson, Sarah Malone, Claudia L. Hilton Phd, Karthik Mani

Translational Science in Occupation

Importance: Post-COVID patients experience difficulties in their everyday lives due to the persistent nature of their symptoms. This scoping review explores the role of occupational therapists in treating post-COVID patients and examines occupational therapy intervention options for this population.

Objective: This scoping review seeks to answer the following questions: What does the literature say about the role of occupational therapy with post-COVID patients? Which rehabilitation interventions are currently being utilized for treatment? How often are occupational therapists involved in the treatment of and research of post-COVID patient care?

Data Sources: Articles were obtained through an exhaustive search in the following …


Associations Among Psychosocial Factors, Health-Related Quality Of Life, And Adherence In Pediatric Inflammatory Bowel Disease, Cecelia I. Nelson Jan 2024

Associations Among Psychosocial Factors, Health-Related Quality Of Life, And Adherence In Pediatric Inflammatory Bowel Disease, Cecelia I. Nelson

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inflammatory Bowel Disease (IBD) is a prevalent disorder among youth in the United States. IBD is one of the leading causes of chronic pain in adolescence and symptoms can lead to reduced quality of life, social embarrassment, and lower self-esteem. Adherence to medical regimens for IBD is incredibly important to prevent morbidity, mortality, and impaired health-related quality of life (HRQOL). However, adolescents struggle generally with adherence and the regimen for IBD can be complicated and include aversive side effects. Psychological factors, such as depressive symptoms, are key factors associated with non-adherence. Nevertheless, gut-specific anxiety (GSA) is a psychological factor that …


Impacts Of Community Food Outreach Programs On Low-Income Families: St. Ursula’S Food Outreach Program In Pursglove Monongalia, West Virginia, United States As A Case Study, Oluwafunke Abeleje Jan 2024

Impacts Of Community Food Outreach Programs On Low-Income Families: St. Ursula’S Food Outreach Program In Pursglove Monongalia, West Virginia, United States As A Case Study, Oluwafunke Abeleje

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Impacts Of Community Food Outreach Programs on Low-Income Families: St. Ursula’s Food Outreach Program in Pursglove Monongalia, West Virginia as A Case Study

Abeleje Oluwafunke Rebecca

According to previous research studies as stated by Fatka (2023), in 2014, 14% of households in the United States had levels of food insecurity. Also, as noted by Pitts, 2020, food insecurity rates rose across the board in the United States during the early COVID-19 epidemic and tripled among families with children. Compared to other industrialized countries, the United States had very high rates of food insecurity before the outbreak (Poblacion et al., …


Adverse Childhood Experiences Predict Mortality Risk: The Role Of Social Support & Social Strain, Meredith A. Willard Jan 2024

Adverse Childhood Experiences Predict Mortality Risk: The Role Of Social Support & Social Strain, Meredith A. Willard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Childhood adversity has long-lasting negative effects across the lifespan including increased mortality risk. The love and support individuals receive from others, also known as social support, has shown to be a protective factor against ACEs. However, little research has investigated the amplifying effects of social conflict and strain that often accompanies social relationships. Utilizing data from the Midlife Development in the U.S. (MIDUS) study, I tested whether higher levels of social support would buffer the negative effects of adverse childhood experiences on mortality risk, and whether higher levels of social strain would amplify these associations. The sample included 6,150 participants …


Effect Of Haemonchus Contortus Excretory/Secretory Protein On Differences In Host Neutrophil Migration, Hannah Grace Teddleton Jan 2024

Effect Of Haemonchus Contortus Excretory/Secretory Protein On Differences In Host Neutrophil Migration, Hannah Grace Teddleton

Graduate Theses, Dissertations, and Problem Reports (ETD)

An excretory/secretory (E/S) product, common to many helminths, is neutrophil inhibitory factor (NIF) which negatively affects neutrophil migration and activity. Due to differences in neutrophil accumulation between parasite resistant St. Croix STC and parasite susceptible Suffolk (SUF) sheep, we hypothesized that Hc-NIF may inhibit migration of SUF and not STC neutrophils. Previous studies have demonstrated that Hc produces NIF but is not commercially available. To test our hypothesis, neutrophils were cultured from STC and SUF sheep in the presence of Ancylostoma caninum-derived NIF (Ac-NIF) and measure chemotaxis to Interleukin-8 (IL-8), HcLA or H. contortus third-stage excretory/secretory (E/S) products. Neutrophils were …


Comparison Between Coronally Advanced Flap With Sub-Epithelial Connective Tissue Graft And Tunnel Technique With Sub-Epithelial Connective Tissue Graft In Achieving Mean Root Coverage At Multiple Recession Defects: A Retrospective Study, Christian Daniel Davila Jan 2024

Comparison Between Coronally Advanced Flap With Sub-Epithelial Connective Tissue Graft And Tunnel Technique With Sub-Epithelial Connective Tissue Graft In Achieving Mean Root Coverage At Multiple Recession Defects: A Retrospective Study, Christian Daniel Davila

Graduate Theses, Dissertations, and Problem Reports (ETD)

Aim: The primary objective is to retrospectively compare the mean root coverage (MRC) achieved using a coronally advanced flap and sub-epithelial connective tissue graft (CAF + CTG) with that achieved using the tunnelling technique and sub-epithelial connective tissue graft (TUN + CTG) for the treatment of multiple recession defects. The secondary objectives are to compare the proportion of complete root coverage (CRC) achieved with CAF + CTG compared to TUN + CTG, compare the proportion of CRC achieved in these two techniques with respect to level of training (American board-certified periodontist or Graduate periodontics residents) and to evaluate the …


Puberty-Associated Changes In Kiss1r, Mc3r, And Mc4r In The Ewe, Ashleigh Caitlyn Thomson Jan 2024

Puberty-Associated Changes In Kiss1r, Mc3r, And Mc4r In The Ewe, Ashleigh Caitlyn Thomson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The neural mechanisms that control the onset of puberty are not completely understood. In livestock, the onset of puberty relies on an increase in gonadotropin releasing hormone (GnRH) and luteinizing hormone (LH). Kisspeptin, neurokinin B, and dynorphin neurons (KNDy) and their receptors, Kiss1r, NK3R, and KOR, respectively, are important regulators of puberty. Previous data from our laboratory has shown that KNDy neurons may be responding to other inputs, including the melanocortin system, that will affect the timing of puberty. Given this, we examined kisspeptin receptor (Kiss1r) mRNA expression in GnRH neurons as well as examining melanocortin 3 and 4 receptor …


Investigating Changing Macronutrient Dynamics At A Plant, Microbe And Plant-Microbe Interactions Scale, Emel Kangi Jan 2024

Investigating Changing Macronutrient Dynamics At A Plant, Microbe And Plant-Microbe Interactions Scale, Emel Kangi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nutrient limitation drives forest ecosystem processes by altering net primary production, belowground (C) investments, and microbial activity. As such, the availability of essential macronutrients, such as nitrogen (N) and phosphorus (P), can severely impact plant growth, microbial decomposition, and the strength of plant-microbial interactions. However, our understanding of plant and microbe responses to changing nutrient availability, and the extent to which nutrient availability affects plant-microbe interactions, remains somewhat limited. Therefore, in this dissertation, I aimed to investigate nutrient limitation on a plant, microbe, and plant-microbe interaction level. First, to connect the phenotypic responses of nutrient-limited plants to key molecular mechanisms, …


Improving Patient Self-Advocacy And Communication With Providers Through Diabetes Self-Management Education: Analyses From A Randomized Controlled Trial, Brenna Owens Kirk Jan 2024

Improving Patient Self-Advocacy And Communication With Providers Through Diabetes Self-Management Education: Analyses From A Randomized Controlled Trial, Brenna Owens Kirk

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: West Virginia (WV), a rural state in Appalachia, has the highest type 2 diabetes mellitus (T2DM) prevalence in the United States. Open communication in the patient-provider relationship is an integral part of comprehensive chronic disease management. This is especially true for patients living with T2DM, a disease that requires many complex, daily self-management activities and is associated with increased emotional distress. However, patients living with T2DM are often reluctant to openly share their concerns regarding self-care with their provider. This study aimed to test the effectiveness of the Diabetes and Hypertension Self-Management Program (DHSMP), a 12-week group lifestyle …


Risk Of Parasiticides To Dung-Associated Beetles In West Virginia, Haylie J. Brown Jan 2024

Risk Of Parasiticides To Dung-Associated Beetles In West Virginia, Haylie J. Brown

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ecosystem services provided by dung-associated beetles, such as reducing pasture fouling, parasite suppression, supporting nutrient recycling, and increasing water infiltration, contribute to animal and pasture health. However, parasiticides used to manage cattle parasites, particularly flies and helminths, in West Virginia, can adversely affect these non-target beetles. We assessed the exposure and impact of some parasiticides used in WV including Clarifly® (active ingredient [a.i.] diflubenzuron), Cydectin® (a.i. moxidectin), LongRange® (a.i. eprinomectin), and Safe-guard® (a.i. fenbendazole). In Chapter 1, we review the use of parasiticides in the US and their non-target effects on beneficial dung-associated beetles. In Chapter …


The Effects Of Feed Manufacture On Exogenous Enzymes, Starch Gelatinization, And Antinutritional Factors Associated With Soybeans, Kristina M. Bowen Jan 2024

The Effects Of Feed Manufacture On Exogenous Enzymes, Starch Gelatinization, And Antinutritional Factors Associated With Soybeans, Kristina M. Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

This doctorate dissertation consists of four individual studies with the overarching theme of the effect of feed manufacture on exogenous enzymes and antinutrients found in soybeans.

Study 1. Including exogenous enzymes in poultry diets can liberate nutrients that are typically inaccessible to monogastric animals. Phytase feeding research has traditionally been conducted by rearing broilers in raised wire cages, whereas commercially grown broilers are reared on built-up litter. Therefore, cage-based studies may not accurately represent commercial bird performance response to phytase. Birds with access to litter consume it, possibly increasing phosphorus intake leading to suggestions that lower phytase concentrations are required. …


The Effects Of Diet-Induced Obesity On Cerebral Microvascular Bioenergetics, Alec Anthony Hanshew Jan 2024

The Effects Of Diet-Induced Obesity On Cerebral Microvascular Bioenergetics, Alec Anthony Hanshew

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obesity is a worldwide epidemic but is especially a concern in the United States with over 40% of the population being obese. Obesity is known to cause increased metabolic demand, systemic inflammation, peripheral vascular dysfunction, and increased levels of oxidative stress and reactive oxygen species (ROS). However, the role of obesity on cerebrovascular bioenergetic function has not been fully elucidated. This study aimed to determine the impact of diet-induced obesity on cerebrovascular bioenergetics. 72, 6-month-old C57Bl/6 male and female mice were randomized into control and HFD groups. Control mice were subjected to the feeding of standard chow (18% fat, 24% …


The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson Jan 2024

The Development, Implementation And Evaluation Of A Novel Intervention For Delirium Prevention And Management In An Adult Intensive Care Unit: A Mixed Methods Study, Gideon Ugochukwu Johnson

Theses: Doctorates and Masters

Background: Delirium is a prevalent acute brain dysfunction in patients within intensive care units. Delirium is marked by a fluctuating mental state, inattention, and altered consciousness. This condition affects a substantial proportion of patients in intensive care units, and which leads to increased mortality, severe physiological and psychological consequences, and a significant economic burden on healthcare systems. Despite the evidence that supports the use of non-pharmacological interventions to prevent or minimise the impact of delirium such as orientation, sensory stimulation, early mobilisation, and family involvement, their implementation in intensive care units remains inconsistent. The involvement of family members in the …


Performance And Physiological Impacts Of Branched-Chain Amino Acid And Tryptophan Ratio Variations In Turkey Starter Diets Utilizing Concentrated Corn Proteins, Emily Blair Estanich Jan 2024

Performance And Physiological Impacts Of Branched-Chain Amino Acid And Tryptophan Ratio Variations In Turkey Starter Diets Utilizing Concentrated Corn Proteins, Emily Blair Estanich

Graduate Theses, Dissertations, and Problem Reports (ETD)

In Chapter 2, a study was designed to evaluate the effects of varying dietary branched-chain amino acids (BCAA) ratio in corn and soybean meal-based turkey starter diets. The BCAA leucine, isoleucine, and valine are considered indispensable amino acids needed for energy and stimulation of muscle protein synthesis via the mammalian target of rapamycin (mTOR) pathway. Imbalanced BCAA ratios can lead to antagonism and degradation of limiting BCAA, particularly in diets with excess leucine. Concentrated corn proteins contain high levels of leucine and can alter BCAA requirements; however, crystalline BCAA may be added to correct these ratios. This study aimed to …