Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Social and Behavioral Sciences (7689)
- Arts and Humanities (5655)
- Medicine and Health Sciences (4574)
- Education (4498)
- Law (3952)
-
- Life Sciences (2404)
- Physical Sciences and Mathematics (2234)
- Business (1707)
- Engineering (1620)
- Communication (1450)
- Sociology (1444)
- Higher Education (1399)
- Psychology (1378)
- Medical Specialties (1283)
- Medical Sciences (1095)
- Art and Design (1062)
- History (946)
- Public Affairs, Public Policy and Public Administration (917)
- Public Health (882)
- Computer Sciences (826)
- Library and Information Science (730)
- Film and Media Studies (694)
- Political Science (675)
- Religion (665)
- Feminist, Gender, and Sexuality Studies (613)
- Creative Writing (521)
- Oncology (502)
- English Language and Literature (494)
- Curriculum and Instruction (485)
- Biomedical Informatics (478)
- Institution
-
- University of Montana (1201)
- The Texas Medical Center Library (998)
- University of South Florida (803)
- Liberty University (737)
- Brigham Young University (717)
-
- Walden University (715)
- Chulalongkorn University (687)
- Universitas Indonesia (634)
- University of Nebraska - Lincoln (583)
- Ateneo de Manila University (496)
- University of South Carolina (478)
- City University of New York (CUNY) (476)
- University of Kentucky (440)
- San Jose State University (436)
- University of Arkansas, Fayetteville (381)
- University of New Hampshire (375)
- Utah State University (363)
- Kennesaw State University (355)
- Nova Southeastern University (352)
- University of Plymouth (345)
- University of Mississippi (332)
- University of Central Florida (312)
- Singapore Management University (309)
- New Jersey Institute of Technology (305)
- Portland State University (278)
- Georgia Southern University (276)
- Syracuse University (269)
- Clemson University (268)
- University of Texas Rio Grande Valley (263)
- Louisiana State University (258)
- Keyword
-
- Humans (919)
- Animals (433)
- Female (417)
- Social media (357)
- Education (355)
-
- COVID-19 (346)
- Mice (346)
- Male (324)
- Mental health (271)
- Artificial intelligence (256)
- Higher education (217)
- Adult (192)
- ICTS (Institute of Clinical and Translational Sciences) (190)
- Technology (186)
- Communication (184)
- Gender (183)
- Artificial Intelligence (160)
- AI (152)
- Identity (152)
- Leadership (150)
- Sustainability (148)
- Newsletter (146)
- UAB (145)
- Machine learning (144)
- Diversity (143)
- Social Media (143)
- United States (141)
- Middle Aged (138)
- Women (138)
- Climate change (136)
- Publication
-
- Theses and Dissertations (1374)
- University of Montana Course Syllabi, 2021-2025 (1009)
- Walden Dissertations and Doctoral Studies (671)
- Faculty, Staff and Student Publications (621)
- Chulalongkorn University Theses and Dissertations (Chula ETD) (535)
-
- Doctoral Dissertations and Projects (502)
- Faculty Publications (389)
- Electronic Theses and Dissertations (364)
- Dissertations (329)
- Kritika Kultura (327)
- Faculty Scholarship (284)
- Faculty, Staff and Students Publications (259)
- Honors Theses (249)
- Theses (247)
- 2020-Current year OA Pubs (214)
- DRS Biennial Conference Series (211)
- Research outputs 2022 to 2026 (211)
- Journal of Issues in Intercollegiate Athletics (208)
- Defensive Publications Series (205)
- Masters Theses (204)
- Articles (192)
- Dissertations, Theses, and Capstone Projects (176)
- Master's Theses (161)
- Dialogue: The Interdisciplinary Journal of Popular Culture and Pedagogy (158)
- The Auk (157)
- USF Tampa Graduate Theses and Dissertations (152)
- Journal of Raptor Research (129)
- Leadership Connection (120)
- Undergraduate Student Symposium (120)
- Graduate Theses and Dissertations (119)
- Publication Type
Articles 661 - 690 of 38877
Full-Text Articles in Entire DC Network
The Impacts And Interplay Of Adolescent Personal Contexts And Sense Of Belonging To Mathematics On Postsecondary Stem Field Interests And Intentions, Monica J. Weir
Dissertations, Theses, and Projects
This quantitative correlational research sought to examine the relationship between high school students’ sense of belonging to mathematics and their interests and intentions to pursue fields of study and careers in science, technology, engineering, and mathematics (STEM). With a theoretical framework based on the belongingness hypothesis and social cognitive career theory (SCCT), the author explicitly linked the universality of the phenomenon of sense of belonging to individual, contextual, environmental, and experiential factors that influence career-related interest development. A sample of 328 high school students attending one private, Catholic, college preparatory school in the Upper Midwest of the United States responded …
Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser
Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser
Theses and Dissertations
This thesis investigates the kinetic modeling of bacteria removal from suspensions using magnetic nanoparticle (MNP) capture and magnetic separation. Functionalized magnetic nanoparticles, especially those coated with polydopamine (pDA), were employed to bind with various bacterial species in phosphate-buffered saline (PBS), apple juice, whole blood, and its components. By analyzing the capture efficiency and kinetics of capture across different bacterial species and mediums, we developed mathematical models describing the capture kinetics of bacteria by the pDA-MNPs. Experimental results demonstrated that pDA-coated MNPs achieved high capture efficiency with certain Gram-positive species like Staphylococcus aureus, and one Gram-negative species, Neisseria perflava; however, capture …
The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham
The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham
Masters Theses
This research was to identify how the Virginia Department of Education handled Music Education during the COVID-19 pandemic. When proper support from the Department of Education is given, music educators can run their programs efficiently without doing much research on their own. By examining the COVID-19 policies and procedures created by the Virginia Department of Education, this qualitative study investigated how much emphasis was put on the unique needs of an education in music. Therefore, this investigation examined these policies and procedures to note in what ways music education was taken into special consideration. This study explored three distinct phases …
Update The Console: Educating The Next Generation About The Benefits/Problems Of Video Games, Nicholas A. Del Rio
Update The Console: Educating The Next Generation About The Benefits/Problems Of Video Games, Nicholas A. Del Rio
Masters Theses
Video games have changed since the late 90s and early 2000s. Technology has advanced, graphics have gotten more detailed, stories and narratives have become more intricate, and gameplay has become more involved. Gaming nowadays is much more accessible, popular, well-known, and widespread compared to back then. It is important to not only know about the roots of video games, but also how it has changed over the years. With many new advancements comes many new benefits and problems. This research covers how video games affect the new generation of gamers, especially children, compared to the older generation of gamers, along …
Early Childhood Teachers’ Perspectives On Implementing Developmentally Appropriate Practice During Online Instruction, Charmaine Bonds
Early Childhood Teachers’ Perspectives On Implementing Developmentally Appropriate Practice During Online Instruction, Charmaine Bonds
Walden Dissertations and Doctoral Studies
Early childhood teachers had to restructure instruction when the COVID-19 pandemic began, and instruction was completed online. The problem was that early childhood teachers faced challenges using developmentally appropriate practice (DAP) in online instruction during the COVID-19 pandemic. The purpose of this basic qualitative study was to explore early childhood teachers’ perspectives on implementing DAP in online instruction during the COVID-19 pandemic and what they needed to improve their use of quality DAP online instruction. The conceptual framework comprised the DAP and the positive technology development theories. The research questions were used to explore pre-K and kindergarten teachers' perspectives on …
Protect Small Businesses: Addressing Security Threats And Insider Risks, Alan Saquella
Protect Small Businesses: Addressing Security Threats And Insider Risks, Alan Saquella
Publications
Small businesses face unique security challenges that make them highly vulnerable compared to larger organizations. While large companies often have dedicated teams of cybersecurity experts, fraud examiners, investigators and the resources to implement robust security measures, small businesses typically operate with limited budgets and minimal staff, making them prime targets for a variety of internal and external threats.
Factors Associated With Cognitive Flexibility In People With Opioid-Use Disorder: A Pilot Study, Paul S. Regier, Thais Costa Macedo De Arruda, Laura Sinko, Anne M. Teitelman, Anna Rose Childress
Factors Associated With Cognitive Flexibility In People With Opioid-Use Disorder: A Pilot Study, Paul S. Regier, Thais Costa Macedo De Arruda, Laura Sinko, Anne M. Teitelman, Anna Rose Childress
College of Nursing Faculty Papers & Presentations
The ability to adapt to changing circumstances has strong survival value. Individuals with substance use disorders tend to get "stuck" over-responding to drug-reward signals and pursuing drugs despite negative consequences. A lack of flexibility may be tied to impairments in neurocognition, including learning, memory, and executive function. However, results are often mixed, potentially due to heterogeneity in factors such as mental health, personality traits, or prior adversity. This study aimed to identify which factors influence neurocognitive variations within the opioid use disorder (OUD) population. Based on prior literature, we hypothesized that individuals with OUD would show deficits (vs. controls) in …
The Impact Of Counselor Educators’ Unprofessional Behavior On Students, Kristin Alyssa Dolph
The Impact Of Counselor Educators’ Unprofessional Behavior On Students, Kristin Alyssa Dolph
Walden Dissertations and Doctoral Studies
Current research into Council for Accreditation of Counseling and Related Educational Programs (CACREP) accredited counseling programs has provided data that counselor educators and supervisors (CESs) who conduct themselves in an unprofessional manner affect their colleagues, peers, and students. Although there is an existing problem of unprofessionalism impacting students, there is a dearth of information on this exploration through a qualitative lens. The purpose of this qualitative descriptive phenomenological study was to describe the lived experiences of counseling students impacted by their CESs displaying unprofessional behaviors. Participants were master’s-level counseling students in a brick and mortar CACREP-accredited program who were either …
Predicting The Effects Of Cyberpatriot Participation, Internet Experience, Gender, And Grade Level On Cybersecurity Judgment (Intuitive And Rational) Among Middle And High School Students: A Quantitative Predictive Correlational Study, Sarah Shin Lee
Doctoral Dissertations and Projects
The purpose of this quantitative, predictive correlational study was to determine if cybersecurity judgment (intuitive and rational) could be predicted from a linear combination of years of CyberPatriot participation, internet experience, gender, and grade level among middle and high school students. The importance of this study lies in its potential to address a critical gap in understanding factors influencing cybersecurity judgment decisions among middle and high school students. From a suburban high school in the western part of the United States, 123 middle and high school students who participated in the CyberPatriot after-school program volunteered as samples in this study. …
The Relationship Between Workplace Bullying And Organizational Commitment: Virtual V. Traditional Working Environment, Christa Lynn Bartholomew
The Relationship Between Workplace Bullying And Organizational Commitment: Virtual V. Traditional Working Environment, Christa Lynn Bartholomew
Doctoral Dissertations and Projects
The purpose of this quantitative correlational study was to examine the relationship between workplace bullying and organizational commitment in a virtual workplace compared to a traditional workplace. The importance of conducting this study was due to workplace bullying having serious implications on physical health, psychological health, family conflict, burnout, and intentional turnover which can have an effect on organizational commitment. A survey utilizing the Negative Acts Questionnaire (Einarsen et al., 1991) and the Organizational Commitment Scale (Balfour and Wechsler, 1996) was distributed to a total sample size of 83 participants. Participants in this study were between the ages of 22-65 …
A Hermeneutic Phenomenological Study: The School Principal's Experiences With Education Law, Vanessa Calderon Donahue
A Hermeneutic Phenomenological Study: The School Principal's Experiences With Education Law, Vanessa Calderon Donahue
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study is to understand the school principal’s experiences with education while managing their school sites. The study applies Knowles' theory of adult learning to create relevant and practical learning and to produce continuous professional development programs on education law for school principals. The central research question guiding this study is: How prepared are principals when addressing legal issues while managing their schools? This hermeneutic phenomenology research study utilizes a constructivist approach to build an understanding of school principals' experiences with education law based on the insights of study participants. The participants comprised ten elementary, …
The Necessity Of Weaknesses In Experiencing The Grace Of God: An Examination Of Paul’S Use Of Grace, Culminating In 2 Corinthians 12:7–10, Jason Scott Shawa
The Necessity Of Weaknesses In Experiencing The Grace Of God: An Examination Of Paul’S Use Of Grace, Culminating In 2 Corinthians 12:7–10, Jason Scott Shawa
Doctoral Dissertations and Projects
Paul’s understanding of weakness, grace, and the power of the risen Christ are all important theological truths. This dissertation’s goal is to show that within the Pauline corpus, Paul’s use of “grace” (specifically χάρις) is often inseparable from the experience of weaknesses. This necessitates the inclusion of weaknesses (e.g., distress, persecution, difficulty, pain, and suffering) for the believer to experience the “grace” God offers in and through the power of the crucified and resurrected Christ.
Paul’s understanding of grace is a subject that has far-reaching implications. Understanding his use of χάρις within his corpus is essential to theological studies and …
Mental Illness In African American Women: A Transcendental Phenomenology On Self-Efficacy And The Treatment-Seeking Behavior Of Secondary And Post-Secondary Educators, Sasha N. Gordon
Doctoral Dissertations and Projects
This transcendental phenomenological research shows the influence of mental health treatment on the self-efficacy of African American women who are secondary or post-secondary educators in Northern Illinois. For African American women educators, taking care of their mental well-being and being aware of mental health conditions are crucial. Sharing personal stories and experiences can help reduce the stigma surrounding mental health. Promoting awareness and understanding of mental health issues are vital in our communities, and access to resources and support are necessary. Using self-identity theory can aid in comprehending motivations and behaviors, leading to greater satisfaction and fulfillment and the prioritization …
Exploring The Uses And Gratifications Of Higher Education Online Multimedia Instructional Tools: A Qualitative Study, Shelby Lord
Exploring The Uses And Gratifications Of Higher Education Online Multimedia Instructional Tools: A Qualitative Study, Shelby Lord
Doctoral Dissertations and Projects
This research study examined the communication goals that motivate California Community College (CCC) faculty to employ multimedia instructional tools in their online classes. Additionally, this study investigated the positive and negative impacts of multimedia instructional tools on faculty-to-student communication. A qualitative research method was utilized for this research study. Findings were obtained from June 2024 through August 2024 using 25 qualitative semi-structured one-on-one interviews. Participants were faculty who were currently teaching remote classes through the CCC system, faculty who approved the informed consent for the study, and faculty who agreed to participate in a semi-structured interview. A thematic analysis process …
The Lived Experiences Of African American Female First-Generation College Students As They Matriculate Through College: A Phenomenological Study, Rosa Denise Mcallister-Mcrae
The Lived Experiences Of African American Female First-Generation College Students As They Matriculate Through College: A Phenomenological Study, Rosa Denise Mcallister-Mcrae
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study was to examine the lived experiences of African American female first-generation college students’ (FGCS) academic, social, emotional, and low economic challenges while attending either a Historically Black College and University (HBCU) or a Predominately White Institution (PWI) located in the southeastern area of the United States. First-generation college students are students whose parents never attended college. Tinto’s retention theory was the framework that guided the research, particularly, the challenges faced by first-generation students. The central research question was, how do African American female FGCSs describe their lived experiences matriculating through an HBCU or …
Edification, Exhortation, And Consolation In A Prophetic Context, Drorester Ornas Alexander Ii
Edification, Exhortation, And Consolation In A Prophetic Context, Drorester Ornas Alexander Ii
Doctoral Dissertations and Projects
According to 1 Corinthians 14 and Ephesians 4, edifying one another is necessary for building Christ’s body in love. Wayne Grudem, a notable theologian, stated that the gift of prophecy in the New Testament is “a human being reporting in merely human words something that God has brought to mind.” The researcher explored how and in what way people are affected by the words of prophecy in a New Testament context. Does the gift of prophecy in Christian music recordings from 2014 to 2024 provide consolation, edification, and exhortation to individuals identifying with Continuationists?
In examining songs containing prophetic contours, …
Racial Reconciliation In Black And White: A Qualitative Study Of Live Mississippi Blues Music Communication, Christian Patterson
Racial Reconciliation In Black And White: A Qualitative Study Of Live Mississippi Blues Music Communication, Christian Patterson
Doctoral Dissertations and Projects
The purpose of this qualitative phenomenological research effort is to investigate a problem regarding communication between Black and White Mississippians in live Mississippi blues music settings. The central research question for this study is as follows: Can live Mississippi blues music communication be used as a tool to strengthen race relations between Black and White Mississippians? Few studies exist regarding this matter. Understanding this phenomenon is relevant because racial reconciliation is critical to the Magnolia State’s future success, and research has proven that music can unify individuals. To facilitate comprehension, a thorough literature review describes Mississippi’s racial challenges from the …
Influence Of Social Media On Business Performance Of Small And Medium Enterprises, Annmarie Jennifer Calvert-Antoye
Influence Of Social Media On Business Performance Of Small And Medium Enterprises, Annmarie Jennifer Calvert-Antoye
Walden Dissertations and Doctoral Studies
Despite the significant advantages of using social media marketing, an estimated 25% of small to medium enterprises (SMEs) promote products and services through social media. However, the lack of use by many convenience store managers often results in missed opportunities for increasing sales revenue and reaching a broader customer base. Grounded in the technology acceptance model, this qualitative descriptive study explored convenience store owners' social media strategies to increase brand awareness and grow sales to improve performance. The participants were eight convenience store owners in the Midwestern United States. Data were collected using semistructured interviews and a review of public …
When Books Come Alive: Crafting A Clean Book-To-Screen Adaptation Worth Watching, Larah C. Cox
When Books Come Alive: Crafting A Clean Book-To-Screen Adaptation Worth Watching, Larah C. Cox
Masters Theses
The Things We Leave Unfinished is a screenplay adaptation of the novel of the same name by Rebecca Yarros. In this story, audience members will watch as the characters fall in love during both World War II and the present time, and experience how these themes become unbreakable family ties and strong women. This thesis, due to the importance of availability of clean entertainment for Christians to enjoy, explores what is necessary for a filmmaker to provide that kind of film, and seeks to find the answers in what makes a book-to-screen adaptation successful and worthy of an audience (both …
Musical Flow: An Analysis On Optimizing Yoga Sequences For Work-Related Musculoskeletal Symptoms In Choral Teachers, Vanessa Adams
Musical Flow: An Analysis On Optimizing Yoga Sequences For Work-Related Musculoskeletal Symptoms In Choral Teachers, Vanessa Adams
Masters Theses
This qualitative study identified work-related musculoskeletal symptoms that middle and high school choral teachers experienced and identified yoga asanas that may mitigate the physical imbalances that lead to those musculoskeletal symptoms. Previous studies have focused on musculoskeletal symptoms in instrumentalists, conductors, and vocalists. However, a choral teacher’s work includes all those jobs and requires unique tools curated for their work demands. Self-care can be more easily facilitated when tools that fit the specific needs of choral teachers are available. Proper self-care may lead to reduced musculoskeletal symptoms and improved holistic health. Yoga asanas, which target the most reported areas of …
Addressing A Lack Of Counseling Programs To Diminish The Psychological, Emotional, And Mental Impacts Of Church Closure Grief, Marcel Berrios
Addressing A Lack Of Counseling Programs To Diminish The Psychological, Emotional, And Mental Impacts Of Church Closure Grief, Marcel Berrios
Doctoral Dissertations and Projects
Besides spiritual activities, the social activities that happen in church buildings are vital to the functioning of most communities; therefore, churches play a central role in the social fabric and social infrastructure of communities in ways not necessarily thought about until they are no longer around. The looming absence of this role or function of the church becomes the overarching focus to address when an announcement is made that a church is permanently closing. Lost in navigating the business and community aspects of a church closure is the congregation's metamorphic spiritual, emotional, and psychological journey. Subsequently, many church members are …
Student Success And Retention In Online Post-Secondary Education: A Phenomenological Study, Alison Weslake
Student Success And Retention In Online Post-Secondary Education: A Phenomenological Study, Alison Weslake
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to understand the experiences that participants from Northeastern College have in post-secondary online learning environments and recognize the overall factors that lead to student success and retention. The theory that guided this study was Bruner’s constructivist theory as it indicates the influence of experience on cognitive development and encourages the consideration of all factors that may impact the overall learning process. A hermeneutical phenomenological study was conducted with participants from Northeastern College in Ontario, Canada in order to accurately reflect personal experiences with the phenomenon of online post-secondary education. The central research question …
Exploring The Lived Experience Of Women Seeking Treatment For Genito-Pelvic Pain And Penetration Disorder: A Phenomenological Study, Emily M. Lacy
Exploring The Lived Experience Of Women Seeking Treatment For Genito-Pelvic Pain And Penetration Disorder: A Phenomenological Study, Emily M. Lacy
Doctoral Dissertations and Projects
This study explored the lived experiences of women seeking treatment for genito-pelvic pain, aiming to identify how each person experiences barriers and facilitators toward obtaining treatment as well as their outlook on the future regarding treatment. The research sought to provide an understanding of their experiences, with implications for minimizing current barriers and building accessibility and awareness. A qualitative phenomenological design was utilized to obtain the data from participants through semi-structured individual interviews. Nine individual interviews were completed with women between the ages of 27 and 44-years-old who have experienced symptoms of genito-pelvic pain for at least 1 year and …
A Phenomenological Study Of Middle School Teachers Implementing Social-Emotional Learning, Post Covid-19 At A Predominantly Hispanic School, Kutana Nichol Parrish
A Phenomenological Study Of Middle School Teachers Implementing Social-Emotional Learning, Post Covid-19 At A Predominantly Hispanic School, Kutana Nichol Parrish
Doctoral Dissertations and Projects
The purpose of this transcendental phenomenological study is to understand the lived experiences of the ten middle school teachers implementing social and emotional learning, post COVID in a predominately Hispanic suburban school in Gwinnett County School District in Georgia. The theory guided by this study is emotional intelligence by psychologist Daniel Goldman but was first used by Peter Salovey and John Mayer in 1990. Daniel Goldman defines emotional intelligence as having the ability to identify nonverbal cues, using emotion to guide one’s thinking, understanding information that is communicated, and actions of emotions, and the capability to self-regulate emotions. Collaborative for …
The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu
The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu
Walden Dissertations and Doctoral Studies
Although there is a general awareness of the importance of mental health, the role of mental health education in shaping the perceptions and attitudes of Nigerian immigrants in the United States remains understudied. This qualitative study aimed to explore and understand the impact of mental health education on the attitudes and beliefs of Nigerian immigrants in the United States. The theoretical foundation for this study was the health belief model, which posits that an individual’s beliefs about health, perceived risks, and perceived benefits play a significant role in their health behaviors. The central research question concerned how mental health education …
The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu
The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu
Walden Dissertations and Doctoral Studies
Although there is a general awareness of the importance of mental health, the role of mental health education in shaping the perceptions and attitudes of Nigerian immigrants in the United States remains understudied. This qualitative study aimed to explore and understand the impact of mental health education on the attitudes and beliefs of Nigerian immigrants in the United States. The theoretical foundation for this study was the health belief model, which posits that an individual’s beliefs about health, perceived risks, and perceived benefits play a significant role in their health behaviors. The central research question concerned how mental health education …
New Chapters In An Old Book: New Discoveries In Transferrin's Blood Stream Modulators And Analytical Methods, Shelby Thomas Harris
New Chapters In An Old Book: New Discoveries In Transferrin's Blood Stream Modulators And Analytical Methods, Shelby Thomas Harris
Theses and Dissertations
Human serum transferrin is a 79 kDa glycoprotein responsible for the safe transport of iron throughout the blood stream. Transferrin binds up to two ferric ions in two domains known as the N-lobe and C-lobe respectively. Thus, there are four transferrin metalloforms: apo-Tf (with no iron bound), FeN-Tf (with one iron bound in the N-lobe), FeC-Tf (with one iron bound in the C-lobe) and holo-Tf(with two iron ions bound, one in each of the lobes). The two domains are homologous but feature differences in the kinetics and thermodynamics of iron binding and release. The two lobes are also different in …
Synthesis, Characterization, And Investigation Of Photochemical And In Vitro Properties Of Novel Zn(Ii) Phthalocyanine, Yasemi̇n Bayğu Yildiz, Ni̇lgün Kabay, Burak Yildiz, İpek Ömeroğlu, Mahmut Durmuş, E. Riza Karagür, Hakan Akça, Çağri Ergi̇n, Yaşar Gök
Synthesis, Characterization, And Investigation Of Photochemical And In Vitro Properties Of Novel Zn(Ii) Phthalocyanine, Yasemi̇n Bayğu Yildiz, Ni̇lgün Kabay, Burak Yildiz, İpek Ömeroğlu, Mahmut Durmuş, E. Riza Karagür, Hakan Akça, Çağri Ergi̇n, Yaşar Gök
Turkish Journal of Chemistry
In our work, a new non-peripheral zinc(II) phthalocyanine bearing octa carboxylic acid ethyl ester derivative substituted triazole attached propylmercaptothiobenzylmercapto derivative was synthesized by the tetramerization reaction of phthalonitrile. The photochemical in vitro photodynamic activity of zinc(II) phthalocyanine (ZnPc-I), such as human non-small cell lung carcinoma cell lines, was investigated in this study. The singlet oxygen generation property of novel zinc(II) phthalocyanine (ZnPc-I) was also examined due to the significantly high singlet oxygen quantum yield of ZnPc-I (ΦΔ = 0.66). The antiproliferative effects of ZnPc-I were also investigated on A549 and H1299 cell lines, our results demonstrate that the ZnPc-I has …
A Fast And Responsive Turn-On Fluorescent Probe Based On A Quinone Conjugated Alkoxy Derivative For Biothiols And A Cellular Imaging Study, Ulviyye Nemetova, Ayşe Nur Önem, Alev Er, Sefa Çeli̇k, Ayşen E. Özel, Sevi̇m Akyüz, Mustafa Özyürek, Si̇bel Şahi̇nler Ayla
A Fast And Responsive Turn-On Fluorescent Probe Based On A Quinone Conjugated Alkoxy Derivative For Biothiols And A Cellular Imaging Study, Ulviyye Nemetova, Ayşe Nur Önem, Alev Er, Sefa Çeli̇k, Ayşen E. Özel, Sevi̇m Akyüz, Mustafa Özyürek, Si̇bel Şahi̇nler Ayla
Turkish Journal of Chemistry
Detection of intracellular biothiols (cysteine (CYS), N-acetyl cysteine (NAC) and glutathione (GSH)) with high-selectivity and sensitivity is important to reveal biological functions. In this study, 2-(2-methoxy-4-methylphenoxy)-3-chloro-5,8-dihydroxynaphthalene-1,4-dione (3) (DDN-O) compound was newly synthesized and used as a fluorogenic probe (detector molecule) in the fluorometric method for the rapid, highly selective and sensitive determination of biothiols. The intensity values (λex = 260 nm, λem = 620 nm) of the product were measured by adding biotihols to the reaction medium at varying concentrations and the glutathione equivalent thiol content (GETC) values of each biotiol were calculated. Using the compoud (3), the reference biotiol …
New Naphthalene-Linked Pyrazoline-Thiazole Hybrids As Prominent Antilung And Antibreast Cancer Inhibitors, Hali̇li̇brahi̇m Çi̇ftçi̇, Masami Otsuka, Mikako Fujita, Belgi̇n Sever
New Naphthalene-Linked Pyrazoline-Thiazole Hybrids As Prominent Antilung And Antibreast Cancer Inhibitors, Hali̇li̇brahi̇m Çi̇ftçi̇, Masami Otsuka, Mikako Fujita, Belgi̇n Sever
Turkish Journal of Chemistry
Epidermal growth factor receptor (EGFR) and HER2, pioneer members of the receptor tyrosine kinase subfamily, are frequently mutated and/or overexpressed in several types of human cancers, including non-small cell lung cancer (NSCLC) and breast cancer, which are leading causes of cancer-related deaths worldwide. EGFR and HER2-focused anti-NSCLC and anti-breast cancer studies encouraged us to search for new potential agents. For this purpose, in the current work, naphthalene-linked pyrazoline-thiazole hybrids (BTT1-10 and BTP1-10) were synthesized and examined for their antiproliferative effects on A549 NSCLC and MCF-7 breast cancer cell lines. According to the results, MTT assay showed that BTT-5 induced strong …