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2024

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The Impacts And Interplay Of Adolescent Personal Contexts And Sense Of Belonging To Mathematics On Postsecondary Stem Field Interests And Intentions, Monica J. Weir Dec 2024

The Impacts And Interplay Of Adolescent Personal Contexts And Sense Of Belonging To Mathematics On Postsecondary Stem Field Interests And Intentions, Monica J. Weir

Dissertations, Theses, and Projects

This quantitative correlational research sought to examine the relationship between high school students’ sense of belonging to mathematics and their interests and intentions to pursue fields of study and careers in science, technology, engineering, and mathematics (STEM). With a theoretical framework based on the belongingness hypothesis and social cognitive career theory (SCCT), the author explicitly linked the universality of the phenomenon of sense of belonging to individual, contextual, environmental, and experiential factors that influence career-related interest development. A sample of 328 high school students attending one private, Catholic, college preparatory school in the Upper Midwest of the United States responded …


Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser Dec 2024

Kinetic Modeling Of Bacteria Removal From Suspensions By Magnetic Nanoparticle Capture And Magnetic Separation, Bowen J. Houser

Theses and Dissertations

This thesis investigates the kinetic modeling of bacteria removal from suspensions using magnetic nanoparticle (MNP) capture and magnetic separation. Functionalized magnetic nanoparticles, especially those coated with polydopamine (pDA), were employed to bind with various bacterial species in phosphate-buffered saline (PBS), apple juice, whole blood, and its components. By analyzing the capture efficiency and kinetics of capture across different bacterial species and mediums, we developed mathematical models describing the capture kinetics of bacteria by the pDA-MNPs. Experimental results demonstrated that pDA-coated MNPs achieved high capture efficiency with certain Gram-positive species like Staphylococcus aureus, and one Gram-negative species, Neisseria perflava; however, capture …


The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham Dec 2024

The Impact Of The Virginia Department Of Education On Music Education During The Covid-19 Pandemic, Erica S. Denham

Masters Theses

This research was to identify how the Virginia Department of Education handled Music Education during the COVID-19 pandemic. When proper support from the Department of Education is given, music educators can run their programs efficiently without doing much research on their own. By examining the COVID-19 policies and procedures created by the Virginia Department of Education, this qualitative study investigated how much emphasis was put on the unique needs of an education in music. Therefore, this investigation examined these policies and procedures to note in what ways music education was taken into special consideration. This study explored three distinct phases …


Update The Console: Educating The Next Generation About The Benefits/Problems Of Video Games, Nicholas A. Del Rio Dec 2024

Update The Console: Educating The Next Generation About The Benefits/Problems Of Video Games, Nicholas A. Del Rio

Masters Theses

Video games have changed since the late 90s and early 2000s. Technology has advanced, graphics have gotten more detailed, stories and narratives have become more intricate, and gameplay has become more involved. Gaming nowadays is much more accessible, popular, well-known, and widespread compared to back then. It is important to not only know about the roots of video games, but also how it has changed over the years. With many new advancements comes many new benefits and problems. This research covers how video games affect the new generation of gamers, especially children, compared to the older generation of gamers, along …


Early Childhood Teachers’ Perspectives On Implementing Developmentally Appropriate Practice During Online Instruction, Charmaine Bonds Dec 2024

Early Childhood Teachers’ Perspectives On Implementing Developmentally Appropriate Practice During Online Instruction, Charmaine Bonds

Walden Dissertations and Doctoral Studies

Early childhood teachers had to restructure instruction when the COVID-19 pandemic began, and instruction was completed online. The problem was that early childhood teachers faced challenges using developmentally appropriate practice (DAP) in online instruction during the COVID-19 pandemic. The purpose of this basic qualitative study was to explore early childhood teachers’ perspectives on implementing DAP in online instruction during the COVID-19 pandemic and what they needed to improve their use of quality DAP online instruction. The conceptual framework comprised the DAP and the positive technology development theories. The research questions were used to explore pre-K and kindergarten teachers' perspectives on …


Protect Small Businesses: Addressing Security Threats And Insider Risks, Alan Saquella Dec 2024

Protect Small Businesses: Addressing Security Threats And Insider Risks, Alan Saquella

Publications

Small businesses face unique security challenges that make them highly vulnerable compared to larger organizations. While large companies often have dedicated teams of cybersecurity experts, fraud examiners, investigators and the resources to implement robust security measures, small businesses typically operate with limited budgets and minimal staff, making them prime targets for a variety of internal and external threats.


Factors Associated With Cognitive Flexibility In People With Opioid-Use Disorder: A Pilot Study, Paul S. Regier, Thais Costa Macedo De Arruda, Laura Sinko, Anne M. Teitelman, Anna Rose Childress Dec 2024

Factors Associated With Cognitive Flexibility In People With Opioid-Use Disorder: A Pilot Study, Paul S. Regier, Thais Costa Macedo De Arruda, Laura Sinko, Anne M. Teitelman, Anna Rose Childress

College of Nursing Faculty Papers & Presentations

The ability to adapt to changing circumstances has strong survival value. Individuals with substance use disorders tend to get "stuck" over-responding to drug-reward signals and pursuing drugs despite negative consequences. A lack of flexibility may be tied to impairments in neurocognition, including learning, memory, and executive function. However, results are often mixed, potentially due to heterogeneity in factors such as mental health, personality traits, or prior adversity. This study aimed to identify which factors influence neurocognitive variations within the opioid use disorder (OUD) population. Based on prior literature, we hypothesized that individuals with OUD would show deficits (vs. controls) in …


The Impact Of Counselor Educators’ Unprofessional Behavior On Students, Kristin Alyssa Dolph Dec 2024

The Impact Of Counselor Educators’ Unprofessional Behavior On Students, Kristin Alyssa Dolph

Walden Dissertations and Doctoral Studies

Current research into Council for Accreditation of Counseling and Related Educational Programs (CACREP) accredited counseling programs has provided data that counselor educators and supervisors (CESs) who conduct themselves in an unprofessional manner affect their colleagues, peers, and students. Although there is an existing problem of unprofessionalism impacting students, there is a dearth of information on this exploration through a qualitative lens. The purpose of this qualitative descriptive phenomenological study was to describe the lived experiences of counseling students impacted by their CESs displaying unprofessional behaviors. Participants were master’s-level counseling students in a brick and mortar CACREP-accredited program who were either …


Predicting The Effects Of Cyberpatriot Participation, Internet Experience, Gender, And Grade Level On Cybersecurity Judgment (Intuitive And Rational) Among Middle And High School Students: A Quantitative Predictive Correlational Study, Sarah Shin Lee Dec 2024

Predicting The Effects Of Cyberpatriot Participation, Internet Experience, Gender, And Grade Level On Cybersecurity Judgment (Intuitive And Rational) Among Middle And High School Students: A Quantitative Predictive Correlational Study, Sarah Shin Lee

Doctoral Dissertations and Projects

The purpose of this quantitative, predictive correlational study was to determine if cybersecurity judgment (intuitive and rational) could be predicted from a linear combination of years of CyberPatriot participation, internet experience, gender, and grade level among middle and high school students. The importance of this study lies in its potential to address a critical gap in understanding factors influencing cybersecurity judgment decisions among middle and high school students. From a suburban high school in the western part of the United States, 123 middle and high school students who participated in the CyberPatriot after-school program volunteered as samples in this study. …


The Relationship Between Workplace Bullying And Organizational Commitment: Virtual V. Traditional Working Environment, Christa Lynn Bartholomew Dec 2024

The Relationship Between Workplace Bullying And Organizational Commitment: Virtual V. Traditional Working Environment, Christa Lynn Bartholomew

Doctoral Dissertations and Projects

The purpose of this quantitative correlational study was to examine the relationship between workplace bullying and organizational commitment in a virtual workplace compared to a traditional workplace. The importance of conducting this study was due to workplace bullying having serious implications on physical health, psychological health, family conflict, burnout, and intentional turnover which can have an effect on organizational commitment. A survey utilizing the Negative Acts Questionnaire (Einarsen et al., 1991) and the Organizational Commitment Scale (Balfour and Wechsler, 1996) was distributed to a total sample size of 83 participants. Participants in this study were between the ages of 22-65 …


A Hermeneutic Phenomenological Study: The School Principal's Experiences With Education Law, Vanessa Calderon Donahue Dec 2024

A Hermeneutic Phenomenological Study: The School Principal's Experiences With Education Law, Vanessa Calderon Donahue

Doctoral Dissertations and Projects

The purpose of this hermeneutic phenomenological study is to understand the school principal’s experiences with education while managing their school sites. The study applies Knowles' theory of adult learning to create relevant and practical learning and to produce continuous professional development programs on education law for school principals. The central research question guiding this study is: How prepared are principals when addressing legal issues while managing their schools? This hermeneutic phenomenology research study utilizes a constructivist approach to build an understanding of school principals' experiences with education law based on the insights of study participants. The participants comprised ten elementary, …


The Necessity Of Weaknesses In Experiencing The Grace Of God: An Examination Of Paul’S Use Of Grace, Culminating In 2 Corinthians 12:7–10, Jason Scott Shawa Dec 2024

The Necessity Of Weaknesses In Experiencing The Grace Of God: An Examination Of Paul’S Use Of Grace, Culminating In 2 Corinthians 12:7–10, Jason Scott Shawa

Doctoral Dissertations and Projects

Paul’s understanding of weakness, grace, and the power of the risen Christ are all important theological truths. This dissertation’s goal is to show that within the Pauline corpus, Paul’s use of “grace” (specifically χάρις) is often inseparable from the experience of weaknesses. This necessitates the inclusion of weaknesses (e.g., distress, persecution, difficulty, pain, and suffering) for the believer to experience the “grace” God offers in and through the power of the crucified and resurrected Christ.

Paul’s understanding of grace is a subject that has far-reaching implications. Understanding his use of χάρις within his corpus is essential to theological studies and …


Mental Illness In African American Women: A Transcendental Phenomenology On Self-Efficacy And The Treatment-Seeking Behavior Of Secondary And Post-Secondary Educators, Sasha N. Gordon Dec 2024

Mental Illness In African American Women: A Transcendental Phenomenology On Self-Efficacy And The Treatment-Seeking Behavior Of Secondary And Post-Secondary Educators, Sasha N. Gordon

Doctoral Dissertations and Projects

This transcendental phenomenological research shows the influence of mental health treatment on the self-efficacy of African American women who are secondary or post-secondary educators in Northern Illinois. For African American women educators, taking care of their mental well-being and being aware of mental health conditions are crucial. Sharing personal stories and experiences can help reduce the stigma surrounding mental health. Promoting awareness and understanding of mental health issues are vital in our communities, and access to resources and support are necessary. Using self-identity theory can aid in comprehending motivations and behaviors, leading to greater satisfaction and fulfillment and the prioritization …


Exploring The Uses And Gratifications Of Higher Education Online Multimedia Instructional Tools: A Qualitative Study, Shelby Lord Dec 2024

Exploring The Uses And Gratifications Of Higher Education Online Multimedia Instructional Tools: A Qualitative Study, Shelby Lord

Doctoral Dissertations and Projects

This research study examined the communication goals that motivate California Community College (CCC) faculty to employ multimedia instructional tools in their online classes. Additionally, this study investigated the positive and negative impacts of multimedia instructional tools on faculty-to-student communication. A qualitative research method was utilized for this research study. Findings were obtained from June 2024 through August 2024 using 25 qualitative semi-structured one-on-one interviews. Participants were faculty who were currently teaching remote classes through the CCC system, faculty who approved the informed consent for the study, and faculty who agreed to participate in a semi-structured interview. A thematic analysis process …


The Lived Experiences Of African American Female First-Generation College Students As They Matriculate Through College: A Phenomenological Study, Rosa Denise Mcallister-Mcrae Dec 2024

The Lived Experiences Of African American Female First-Generation College Students As They Matriculate Through College: A Phenomenological Study, Rosa Denise Mcallister-Mcrae

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study was to examine the lived experiences of African American female first-generation college students’ (FGCS) academic, social, emotional, and low economic challenges while attending either a Historically Black College and University (HBCU) or a Predominately White Institution (PWI) located in the southeastern area of the United States. First-generation college students are students whose parents never attended college. Tinto’s retention theory was the framework that guided the research, particularly, the challenges faced by first-generation students. The central research question was, how do African American female FGCSs describe their lived experiences matriculating through an HBCU or …


Edification, Exhortation, And Consolation In A Prophetic Context, Drorester Ornas Alexander Ii Dec 2024

Edification, Exhortation, And Consolation In A Prophetic Context, Drorester Ornas Alexander Ii

Doctoral Dissertations and Projects

According to 1 Corinthians 14 and Ephesians 4, edifying one another is necessary for building Christ’s body in love. Wayne Grudem, a notable theologian, stated that the gift of prophecy in the New Testament is “a human being reporting in merely human words something that God has brought to mind.” The researcher explored how and in what way people are affected by the words of prophecy in a New Testament context. Does the gift of prophecy in Christian music recordings from 2014 to 2024 provide consolation, edification, and exhortation to individuals identifying with Continuationists?

In examining songs containing prophetic contours, …


Racial Reconciliation In Black And White: A Qualitative Study Of Live Mississippi Blues Music Communication, Christian Patterson Dec 2024

Racial Reconciliation In Black And White: A Qualitative Study Of Live Mississippi Blues Music Communication, Christian Patterson

Doctoral Dissertations and Projects

The purpose of this qualitative phenomenological research effort is to investigate a problem regarding communication between Black and White Mississippians in live Mississippi blues music settings. The central research question for this study is as follows: Can live Mississippi blues music communication be used as a tool to strengthen race relations between Black and White Mississippians? Few studies exist regarding this matter. Understanding this phenomenon is relevant because racial reconciliation is critical to the Magnolia State’s future success, and research has proven that music can unify individuals. To facilitate comprehension, a thorough literature review describes Mississippi’s racial challenges from the …


Influence Of Social Media On Business Performance Of Small And Medium Enterprises, Annmarie Jennifer Calvert-Antoye Dec 2024

Influence Of Social Media On Business Performance Of Small And Medium Enterprises, Annmarie Jennifer Calvert-Antoye

Walden Dissertations and Doctoral Studies

Despite the significant advantages of using social media marketing, an estimated 25% of small to medium enterprises (SMEs) promote products and services through social media. However, the lack of use by many convenience store managers often results in missed opportunities for increasing sales revenue and reaching a broader customer base. Grounded in the technology acceptance model, this qualitative descriptive study explored convenience store owners' social media strategies to increase brand awareness and grow sales to improve performance. The participants were eight convenience store owners in the Midwestern United States. Data were collected using semistructured interviews and a review of public …


When Books Come Alive: Crafting A Clean Book-To-Screen Adaptation Worth Watching, Larah C. Cox Dec 2024

When Books Come Alive: Crafting A Clean Book-To-Screen Adaptation Worth Watching, Larah C. Cox

Masters Theses

The Things We Leave Unfinished is a screenplay adaptation of the novel of the same name by Rebecca Yarros. In this story, audience members will watch as the characters fall in love during both World War II and the present time, and experience how these themes become unbreakable family ties and strong women. This thesis, due to the importance of availability of clean entertainment for Christians to enjoy, explores what is necessary for a filmmaker to provide that kind of film, and seeks to find the answers in what makes a book-to-screen adaptation successful and worthy of an audience (both …


Musical Flow: An Analysis On Optimizing Yoga Sequences For Work-Related Musculoskeletal Symptoms In Choral Teachers, Vanessa Adams Dec 2024

Musical Flow: An Analysis On Optimizing Yoga Sequences For Work-Related Musculoskeletal Symptoms In Choral Teachers, Vanessa Adams

Masters Theses

This qualitative study identified work-related musculoskeletal symptoms that middle and high school choral teachers experienced and identified yoga asanas that may mitigate the physical imbalances that lead to those musculoskeletal symptoms. Previous studies have focused on musculoskeletal symptoms in instrumentalists, conductors, and vocalists. However, a choral teacher’s work includes all those jobs and requires unique tools curated for their work demands. Self-care can be more easily facilitated when tools that fit the specific needs of choral teachers are available. Proper self-care may lead to reduced musculoskeletal symptoms and improved holistic health. Yoga asanas, which target the most reported areas of …


Addressing A Lack Of Counseling Programs To Diminish The Psychological, Emotional, And Mental Impacts Of Church Closure Grief, Marcel Berrios Dec 2024

Addressing A Lack Of Counseling Programs To Diminish The Psychological, Emotional, And Mental Impacts Of Church Closure Grief, Marcel Berrios

Doctoral Dissertations and Projects

Besides spiritual activities, the social activities that happen in church buildings are vital to the functioning of most communities; therefore, churches play a central role in the social fabric and social infrastructure of communities in ways not necessarily thought about until they are no longer around. The looming absence of this role or function of the church becomes the overarching focus to address when an announcement is made that a church is permanently closing. Lost in navigating the business and community aspects of a church closure is the congregation's metamorphic spiritual, emotional, and psychological journey. Subsequently, many church members are …


Student Success And Retention In Online Post-Secondary Education: A Phenomenological Study, Alison Weslake Dec 2024

Student Success And Retention In Online Post-Secondary Education: A Phenomenological Study, Alison Weslake

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to understand the experiences that participants from Northeastern College have in post-secondary online learning environments and recognize the overall factors that lead to student success and retention. The theory that guided this study was Bruner’s constructivist theory as it indicates the influence of experience on cognitive development and encourages the consideration of all factors that may impact the overall learning process. A hermeneutical phenomenological study was conducted with participants from Northeastern College in Ontario, Canada in order to accurately reflect personal experiences with the phenomenon of online post-secondary education. The central research question …


Exploring The Lived Experience Of Women Seeking Treatment For Genito-Pelvic Pain And Penetration Disorder: A Phenomenological Study, Emily M. Lacy Dec 2024

Exploring The Lived Experience Of Women Seeking Treatment For Genito-Pelvic Pain And Penetration Disorder: A Phenomenological Study, Emily M. Lacy

Doctoral Dissertations and Projects

This study explored the lived experiences of women seeking treatment for genito-pelvic pain, aiming to identify how each person experiences barriers and facilitators toward obtaining treatment as well as their outlook on the future regarding treatment. The research sought to provide an understanding of their experiences, with implications for minimizing current barriers and building accessibility and awareness. A qualitative phenomenological design was utilized to obtain the data from participants through semi-structured individual interviews. Nine individual interviews were completed with women between the ages of 27 and 44-years-old who have experienced symptoms of genito-pelvic pain for at least 1 year and …


A Phenomenological Study Of Middle School Teachers Implementing Social-Emotional Learning, Post Covid-19 At A Predominantly Hispanic School, Kutana Nichol Parrish Dec 2024

A Phenomenological Study Of Middle School Teachers Implementing Social-Emotional Learning, Post Covid-19 At A Predominantly Hispanic School, Kutana Nichol Parrish

Doctoral Dissertations and Projects

The purpose of this transcendental phenomenological study is to understand the lived experiences of the ten middle school teachers implementing social and emotional learning, post COVID in a predominately Hispanic suburban school in Gwinnett County School District in Georgia. The theory guided by this study is emotional intelligence by psychologist Daniel Goldman but was first used by Peter Salovey and John Mayer in 1990. Daniel Goldman defines emotional intelligence as having the ability to identify nonverbal cues, using emotion to guide one’s thinking, understanding information that is communicated, and actions of emotions, and the capability to self-regulate emotions. Collaborative for …


The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu Dec 2024

The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu

Walden Dissertations and Doctoral Studies

Although there is a general awareness of the importance of mental health, the role of mental health education in shaping the perceptions and attitudes of Nigerian immigrants in the United States remains understudied. This qualitative study aimed to explore and understand the impact of mental health education on the attitudes and beliefs of Nigerian immigrants in the United States. The theoretical foundation for this study was the health belief model, which posits that an individual’s beliefs about health, perceived risks, and perceived benefits play a significant role in their health behaviors. The central research question concerned how mental health education …


The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu Dec 2024

The Impact Of Mental Health Education On Nigerian Immigrants In The United States, Paschal Chinedu Ukwu

Walden Dissertations and Doctoral Studies

Although there is a general awareness of the importance of mental health, the role of mental health education in shaping the perceptions and attitudes of Nigerian immigrants in the United States remains understudied. This qualitative study aimed to explore and understand the impact of mental health education on the attitudes and beliefs of Nigerian immigrants in the United States. The theoretical foundation for this study was the health belief model, which posits that an individual’s beliefs about health, perceived risks, and perceived benefits play a significant role in their health behaviors. The central research question concerned how mental health education …


New Chapters In An Old Book: New Discoveries In Transferrin's Blood Stream Modulators And Analytical Methods, Shelby Thomas Harris Dec 2024

New Chapters In An Old Book: New Discoveries In Transferrin's Blood Stream Modulators And Analytical Methods, Shelby Thomas Harris

Theses and Dissertations

Human serum transferrin is a 79 kDa glycoprotein responsible for the safe transport of iron throughout the blood stream. Transferrin binds up to two ferric ions in two domains known as the N-lobe and C-lobe respectively. Thus, there are four transferrin metalloforms: apo-Tf (with no iron bound), FeN-Tf (with one iron bound in the N-lobe), FeC-Tf (with one iron bound in the C-lobe) and holo-Tf(with two iron ions bound, one in each of the lobes). The two domains are homologous but feature differences in the kinetics and thermodynamics of iron binding and release. The two lobes are also different in …


Synthesis, Characterization, And Investigation Of Photochemical And In Vitro Properties Of Novel Zn(Ii) Phthalocyanine, Yasemi̇n Bayğu Yildiz, Ni̇lgün Kabay, Burak Yildiz, İpek Ömeroğlu, Mahmut Durmuş, E. Riza Karagür, Hakan Akça, Çağri Ergi̇n, Yaşar Gök Dec 2024

Synthesis, Characterization, And Investigation Of Photochemical And In Vitro Properties Of Novel Zn(Ii) Phthalocyanine, Yasemi̇n Bayğu Yildiz, Ni̇lgün Kabay, Burak Yildiz, İpek Ömeroğlu, Mahmut Durmuş, E. Riza Karagür, Hakan Akça, Çağri Ergi̇n, Yaşar Gök

Turkish Journal of Chemistry

In our work, a new non-peripheral zinc(II) phthalocyanine bearing octa carboxylic acid ethyl ester derivative substituted triazole attached propylmercaptothiobenzylmercapto derivative was synthesized by the tetramerization reaction of phthalonitrile. The photochemical in vitro photodynamic activity of zinc(II) phthalocyanine (ZnPc-I), such as human non-small cell lung carcinoma cell lines, was investigated in this study. The singlet oxygen generation property of novel zinc(II) phthalocyanine (ZnPc-I) was also examined due to the significantly high singlet oxygen quantum yield of ZnPc-I (ΦΔ = 0.66). The antiproliferative effects of ZnPc-I were also investigated on A549 and H1299 cell lines, our results demonstrate that the ZnPc-I has …


A Fast And Responsive Turn-On Fluorescent Probe Based On A Quinone Conjugated Alkoxy Derivative For Biothiols And A Cellular Imaging Study, Ulviyye Nemetova, Ayşe Nur Önem, Alev Er, Sefa Çeli̇k, Ayşen E. Özel, Sevi̇m Akyüz, Mustafa Özyürek, Si̇bel Şahi̇nler Ayla Dec 2024

A Fast And Responsive Turn-On Fluorescent Probe Based On A Quinone Conjugated Alkoxy Derivative For Biothiols And A Cellular Imaging Study, Ulviyye Nemetova, Ayşe Nur Önem, Alev Er, Sefa Çeli̇k, Ayşen E. Özel, Sevi̇m Akyüz, Mustafa Özyürek, Si̇bel Şahi̇nler Ayla

Turkish Journal of Chemistry

Detection of intracellular biothiols (cysteine (CYS), N-acetyl cysteine (NAC) and glutathione (GSH)) with high-selectivity and sensitivity is important to reveal biological functions. In this study, 2-(2-methoxy-4-methylphenoxy)-3-chloro-5,8-dihydroxynaphthalene-1,4-dione (3) (DDN-O) compound was newly synthesized and used as a fluorogenic probe (detector molecule) in the fluorometric method for the rapid, highly selective and sensitive determination of biothiols. The intensity values (λex = 260 nm, λem = 620 nm) of the product were measured by adding biotihols to the reaction medium at varying concentrations and the glutathione equivalent thiol content (GETC) values of each biotiol were calculated. Using the compoud (3), the reference biotiol …


New Naphthalene-Linked Pyrazoline-Thiazole Hybrids As Prominent Antilung And Antibreast Cancer Inhibitors, Hali̇li̇brahi̇m Çi̇ftçi̇, Masami Otsuka, Mikako Fujita, Belgi̇n Sever Dec 2024

New Naphthalene-Linked Pyrazoline-Thiazole Hybrids As Prominent Antilung And Antibreast Cancer Inhibitors, Hali̇li̇brahi̇m Çi̇ftçi̇, Masami Otsuka, Mikako Fujita, Belgi̇n Sever

Turkish Journal of Chemistry

Epidermal growth factor receptor (EGFR) and HER2, pioneer members of the receptor tyrosine kinase subfamily, are frequently mutated and/or overexpressed in several types of human cancers, including non-small cell lung cancer (NSCLC) and breast cancer, which are leading causes of cancer-related deaths worldwide. EGFR and HER2-focused anti-NSCLC and anti-breast cancer studies encouraged us to search for new potential agents. For this purpose, in the current work, naphthalene-linked pyrazoline-thiazole hybrids (BTT1-10 and BTP1-10) were synthesized and examined for their antiproliferative effects on A549 NSCLC and MCF-7 breast cancer cell lines. According to the results, MTT assay showed that BTT-5 induced strong …