Digital Commons Network^™

Researching Covid To Enhance Recovery (Recover) Pediatric Study Protocol: Rationale, Objectives And Design, Rachel S Gross, Tanayott Thaweethai, Erika B Rosenzweig, James Chan, Lori B Chibnik, Mine S Cicek, Amy J Elliott, Valerie J Flaherman, Andrea S Foulkes, Margot Gage Witvliet, Richard Gallagher, Maria Laura Gennaro, Terry L Jernigan, Elizabeth W Karlson, Stuart D Katz, Patricia A Kinser, Lawrence C Kleinman, Michelle F Lamendola-Essel, Joshua D Milner, Sindhu Mohandas, Praveen C Mudumbi, Jane W Newburger, Kyung E Rhee, Amy L Salisbury, Jessica N Snowden, Cheryl R Stein, Melissa S Stockwell, Kelan G Tantisira, Moriah E Thomason, Dongngan T Truong, David Warburton, John C Wood, Shifa Ahmed, Almary Akerlundh, Akram N Alshawabkeh, Brett R Anderson, Judy L Aschner, Andrew M Atz, Robin L Aupperle, Fiona C Baker, Venkataraman Balaraman, Dithi Banerjee, Deanna M Barch, Arielle Baskin-Sommers, Sultana Bhuiyan, Marie-Abele C Bind, Amanda L Bogie, Tamara Bradford, Natalie C Buchbinder, Elliott Bueler, Hülya Bükülmez, B J Casey, Linda Chang, Maryanne Chrisant, Duncan B Clark, Rebecca G Clifton, Katharine N Clouser, Lesley Cottrell, Kelly Cowan, Viren D'Sa, Mirella Dapretto, Soham Dasgupta, Walter Dehority, Audrey Dionne, Kirsten B Dummer, Matthew D Elias, Shari Esquenazi-Karonika, Danielle N Evans, E Vincent S Faustino, Alexander G Fiks, Daniel Forsha, John J Foxe, Naomi P Friedman, Greta Fry, Sunanda Gaur, Dylan G Gee, Kevin M Gray, Stephanie Handler, Ashraf S Harahsheh, Keren Hasbani, Andrew C Heath, Camden Hebson, Mary M Heitzeg, Christina M Hester, Sophia Hill, Laura Hobart-Porter, Travis K F Hong, Carol R Horowitz, Daniel S Hsia, Matthew Huentelman, Kathy D Hummel, Katherine Irby, Joanna Jacobus, Vanessa L Jacoby, Pei-Ni Jone, David C Kaelber, Tyler J Kasmarcak, Matthew J Kluko, Jessica S Kosut, Angela R Laird, Jeremy Landeo-Gutierrez, Sean M Lang, Christine L Larson, Peter Paul C Lim, Krista M Lisdahl, Brian W Mccrindle, Russell J Mcculloh, Kimberly Mchugh, Alan L Mendelsohn, Torri D Metz, Julie Miller, Elizabeth C Mitchell, Lerraughn M Morgan, Eva M Müller-Oehring, Erica R Nahin, Michael C Neale, Manette Ness-Cochinwala, Sheila M Nolan, Carlos R Oliveira, Onyekachukwu Osakwe, Matthew E Oster, R Mark Payne, Michael A Portman, Hengameh Raissy, Isabelle G Randall, Suchitra Rao, Harrison T Reeder, Johana M Rosas, Mark W Russell, Arash A Sabati, Yamuna Sanil, Alice I Sato, Michael S Schechter, Rangaraj Selvarangan, S Kristen Sexson Tejtel, Divya Shakti, Kavita Sharma, Lindsay M Squeglia, Shubika Srivastava, Michelle D Stevenson, Jacqueline Szmuszkovicz, Maria M Talavera-Barber, Ronald J Teufel, Deepika Thacker, Felicia Trachtenberg, Mmekom M Udosen, Megan R Warner, Sara E Watson, Alan Werzberger, Jordan C Weyer, Marion J Wood, H Shonna Yin, William T Zempsky, Emily Zimmerman, Benard P Dreyer, Recover-Pediatric Consortium

Faculty, Staff and Students Publications

IMPORTANCE: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or "Long COVID") in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults.

OBSERVATIONS: We describe the protocol for the Pediatric Observational Cohort Study of the NIH's REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta-cohort study of caregiver-child pairs (birth through 17 years) and young adults (18 through 25 years), recruited from more than 100 sites across the US. This report focuses on two of …

Autophagy Determines Distinct Cell Fates In Human Amnion And Chorion Cells, Mary Elise L Severino, Lauren Richardson, Ananth Kumar Kammala, Enkhtuya Radnaa, Kamil Khanipov, Leslie Michelle M Dalmacio, Indira U Mysorekar, Marian Kacerovsky, Ramkumar Menon

Faculty, Staff and Students Publications

Human fetal membranes (amniochorion) that line the intrauterine cavity consist of two distinct cell layers; single-layer amnion epithelial cells (AEC) and multilayer chorion trophoblast cells (CTC). These layers are connected through a collagen-rich extracellular matrix. Cellular remodeling helps support membrane growth and integrity during gestation and helps to maintain pregnancy. Preterm prelabor rupture of the human amniochorionic (fetal) membrane (pPROM) is antecedent to 40% of all spontaneous preterm birth. Oxidative stress (OS) induced activation of the p38 MAPK due to various maternal risk exposures and the amniochorion cells' senescence are reported pathological features of pPROM. Our transcriptomics analysis implicated dysregulated …

Changes In Patterns Of Referral For Inpatient Rehabilitation Cancer Patients Due To Covid-19: A Retrospective Study, Ekta Gupta, Amy H Ng, Aline Rozman De Moraes, Jack B Fu, Jegy M Tennison, Maaheen Ahmed, Bryan M Fellman, Eduardo Bruera

Faculty, Staff and Students Publications

There is a paucity of literature on the effect of COVID-19 on hospital processes. We hypothesized that COVID-19 was associated with decreased cancer physiatry referrals in 2020. This is a retrospective cohort study of consecutive patients from April to July 2019 and 2020 admitted at an academic quaternary cancer center. The main outcomes were number of hospital admissions, rate, and characteristics of inpatient rehabilitation admissions and change in percentage of physiatry referrals as the primary endpoint. Results showed that in 2019, there were 387 referrals from 10,274 inpatient admissions (3.8%; 95% confidence interval, 2.4-4.2), compared with 337 referrals from 7051 …

Branched-Chain Amino Acid Accumulation Fuels The Senescence-Associated Secretory Phenotype, Yaosi Liang, Christopher Pan, Tao Yin, Lu Wang, Xia Gao, Ergang Wang, Holly Quang, De Huang, Lianmei Tan, Kun Xiang, Yu Wang, Peter B Alexander, Qi-Jing Li, Tso-Pang Yao, Zhao Zhang, Xiao-Fan Wang

Faculty, Staff and Students Publications

The essential branched-chain amino acids (BCAAs) leucine, isoleucine, and valine play critical roles in protein synthesis and energy metabolism. Despite their widespread use as nutritional supplements, BCAAs' full effects on mammalian physiology remain uncertain due to the complexities of BCAA metabolic regulation. Here a novel mechanism linking intrinsic alterations in BCAA metabolism is identified to cellular senescence and the senescence-associated secretory phenotype (SASP), both of which contribute to organismal aging and inflammation-related diseases. Altered BCAA metabolism driving the SASP is mediated by robust activation of the BCAA transporters Solute Carrier Family 6 Members 14 and 15 as well as downregulation …

Call The Experts: Identifying Stakeholders In The Long-Term Care Of Youth With Hypospadias, Vinaya P Bhatia, Kristin Ebert, Shannon Cannon, Walid A Farhat, Heidi W Brown, Jane Mahoney, Marisa E Hilliard, Kristina L Penniston

Faculty, Staff and Students Publications

Long-term follow-up for individuals with hypospadias remains a critical area of need, yet evidence-based guidelines for such follow-up are lacking, and the role of involvement of relevant experts is not yet established. Using our hypospadias-specific health-related quality of life conceptual framework and a subsequent qualitative study of prepubertal males and parents of males with hypospadias, we identified potential priorities for long-term follow-up of youth with hypospadias. Using thematic codes from our patient and parent interviews, we searched PubMed for relevant articles and identified the specialties represented by all the authors of these articles. Our search strategy revealed consistent expertise across …

5-Htp Inhibits Eosinophilia Via Intracellular Endothelial 5-Htrs; Snps In 5-Htrs Associate With Asthmatic Lung Function, Matthew T Walker, Jeffrey C Bloodworth, Timothy S Kountz, Samantha L Mccarty, Jeremy E Green, Ryan P Ferrie, Jackson A Campbell, Samantha H Averill, Kenneth B Beckman, Leslie C Grammer, Celeste Eng, Pedro C Avila, Harold J Farber, William Rodriguez-Cintron, Jose R Rodriguez-Santana, Denise Serebrisky, Shannon M Thyne, Max A Seibold, Esteban G Burchard, Rajesh Kumar, Joan M Cook-Mills

Faculty, Staff and Students Publications

BACKGROUND: Previous research showed that 5-hydroxytryptophan (5HTP), a metabolic precursor of serotonin, reduces allergic lung inflammation by inhibiting eosinophil migration across endothelial monolayers.

OBJECTIVE: It is unknown if serotonin receptors are involved in mediating this 5HTP function or if serotonin receptor (HTR) single nucleotide polymorphisms (SNPs) associate with lung function in humans.

METHODS: Serotonin receptor subtypes were assessed by qPCR, western blot, confocal microscopy, pharmacological inhibitors and siRNA knockdown. HTR SNPs were assessed in two cohorts.

RESULTS: Pharmacological inhibition or siRNA knockdown of the serotonin receptors HTR1A or HTR1B in endothelial cells abrogated the inhibitory effects of 5HTP on eosinophil …

Using A Collaborative Learning Health System Approach To Improve Disease Activity Outcomes In Children With Juvenile Idiopathic Arthritis In The Pediatric Rheumatology Care And Outcomes Improvement Network, Julia G Harris, Catherine A Bingham, Sheetal S Vora, Cagri Yildirim-Toruner, Michelle Batthish, Danielle R Bullock, Jon M Burnham, Danielle C Fair, Kerry Ferraro, Suhas Ganguli, Mileka Gilbert, Beth S Gottlieb, Olha Halyabar, Melissa M Hazen, Ronald M Laxer, Tzielan C Lee, Alice Liu, Daniel J Lovell, Melissa L Mannion, Edward J Oberle, Nancy Pan, Michael Shishov, Jennifer E Weiss, Esi M Morgan

Faculty, Staff and Students Publications

INTRODUCTION: The Pediatric Rheumatology Care and Outcomes Improvement Network (PR-COIN) is a North American learning health network focused on improving outcomes of children with juvenile idiopathic arthritis (JIA). JIA is a chronic autoimmune disease that can lead to morbidity related to persistent joint and ocular inflammation. PR-COIN has a shared patient registry that tracks twenty quality measures including ten outcome measures of which six are related to disease activity. The network's global aim, set in 2021, was to increase the percent of patients with oligoarticular or polyarticular JIA that had an inactive or low disease activity state from 76% to …

Effects And Plasma Proteomic Analysis Of Glp-1ra Versus Cpa/Ee, In Combination With Metformin, On Overweight Pcos Women: A Randomized Controlled Trial, Mingyu Liao, Xing Li, Hao Zhang, Ling Zhou, Liu Shi, Weixin Li, Rufei Shen, Guiliang Peng, Huan Zhao, Jiaqing Shao, Xiujie Wang, Zheng Sun, Hongting Zheng, Min Long

Faculty, Staff and Students Publications

PURPOSE: Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions and metabolic disorders. This study aims to compare the therapeutic effectiveness of glucagon-like peptide-1 receptor agonist (GLP-1RA) + Metformin (Met) versus cyproterone acetate/ethinylestradiol (CPA/EE) + Met in overweight PCOS women and identify potential proteomic biomarkers of disease risk in women with PCOS.

METHODS: In this prospective, open-label randomized controlled trial, we recruited 60 overweight PCOS women into two groups at a 1:1 ratio to receive CPA/EE (2 mg/day: 2 mg cyproterone acetate and 35-μg ethinylestradiol,) +Met (1500 mg/day) or GLP-1 RA (liraglutide, 1.2-1.8 mg/day) +Met (1500 mg/day) for 12 weeks. …

Comparison Of Four Protocols For In Vitro Differentiation Of Human Embryonic Stem Cells Into Trophoblast Lineages By Bmp4 And Dual Inhibition Of Activin/Nodal And Fgf2 Signaling, Zahra Anvar, Imen Chakchouk, Momal Sharif, Sangeetha Mahadevan, Li Su, Swathi Anikar, Fatemeh Alavi Naini, Alloysius Budi Utama, Ignatia B Van Den Veyver

Faculty, Staff and Students Publications

Human embryonic stem cells (hESCs) cultured in media containing bone morphogenic protein 4 (BMP4; B) differentiate into trophoblast-like cells. Supplementing media with inhibitors of activin/nodal signaling (A83-01) and of fibroblast growth factor 2 (PD173074) suppresses mesoderm and endoderm formation and improves specification of trophoblast-like lineages, but with variable effectiveness. We compared differentiation in four BMP4-containing media: mTeSR1-BMP4 only, mTeSR1-BAP, basal medium with BAP (basal-BAP), and a newly defined medium, E7-BAP. These media variably drive early differentiation towards trophoblast-like lineages with upregulation of early trophoblast markers CDX2 and KRT7 and downregulation of pluripotency markers (OCT4 and NANOG). As expected, based on …

The Uterine Secretome Initiates Growth Of Gynecologic Tissues In Ectopic Locations, Jan Sunde, Morgan Wasickanin, Tiffany A Katz, Laurel Gillette, Sanam Bidadi, Derek O'Neil, Ramya Masand, Richard O Burney, Kathleen A Pennington

Faculty, Staff and Students Publications

Endosalpingiosis (ES) and endometriosis (EM) refer to the growth of tubal and endometrial epithelium respectively, outside of their site of origin. We hypothesize that uterine secretome factors drive ectopic growth. To test this, we developed a mouse model of ES and EM using tdTomato (tdT) transgenic fluorescent mice as donors. To block implantation factors, progesterone knockout (PKO) tdT mice were created. Fluorescent lesions were present after oviduct implantation with and without WT endometrium. Implantation was increased (p<0.05) when tdt oviductal tissue was implanted with endometrium compared to oviductal tissue alone. Implantation was reduced (p<0.0005) in animals implanted with minced tdT oviductal tissue with PKO tdT endometrium compared to WT endometrium. Finally, oviductal tissues was incubated with and without a known implantation factor, leukemia inhibitory factor (LIF) prior to and during implantation. LIF promoted lesion implantation. In conclusion, endometrial derived implantation factors, such as LIF, are necessary to initiate ectopic tissue growth. We have developed an animal model of ectopic growth of gynecologic tissues in a WT mouse which will potentially allow for development of new prevention and treatment modalities.

I Can-B Money Savvy! Teaching Adults With Intellectual And Developmental Disabilities To Make Purchasing Decisions Online, Kaley B. Adams

Electronic Theses and Dissertations 2020 - Present

Online shopping is a common feature of modern adult life and is made easy with targeted advertisements, a large buy now button, and pre-entered credit card information. However, these features do not support making purchasing decisions based on what is best for the individual. Decision making about buying items requires an understanding of basic mathematics, one’s current finances and circumstances, and information about the product, then choosing whether to purchase the item. Adults with intellectual and developmental disabilities (IDD) need explicit instruction on how to make informed decisions regarding online purchases. The current study sought to evaluate the effectiveness of …

Identifying Epigenetic Modifications To Combat Resistance To The Chemotherapeutic Agent Doxorubicin, Anna Lesley Kingham

Electronic Theses and Dissertations 2020 - Present

There has been substantial progress in cancer research that has markedly enhanced patient outcomes. However, chemotherapy resistance persists and often leads to multidrug resistance, rendering cancer cells unresponsive to multiple chemotherapy drugs, presenting a significant challenge in the effective treatment of the disease. Dysregulation in gene expression patterns caused by abnormalities in epigenetic mechanisms have been identified as contributing factors to the development and progression of cancer. Epigenetic research offers potential to discover drugs that target specific epigenetic modifications to regulate gene expression patterns in the context of chemotherapy resistance. I hypothesize that histone modifications on histone H3 and histone …

Image-Based Sexual Abuse In The Workplace: Examining The Effects And Responses Of Professional Women, Veronica Tyler Stewart

Electronic Theses and Dissertations 2020 - Present

Although the sensationalized term “Revenge Porn” is used by media outlets to spark conversation about consent and digital privacy, the nonconsensual distribution of intimate media, or “image-based sexual abuse” (IBSA), is the preferred term by scholars for its more accurate depiction of the variety of modes, methods, and damages. I argue that targeted women experience many of the same damages to their socioemotional, interpersonal, and professional well-being that targets of traditional, offline, sexual violence experience, and that the nature and affordances of digital technology often allow these harms to transcend the once isolated contexts in which offline cases of sexual …

Infrastructure And Methods For Wifi-Based Passive Device Localization, Fingerprinting, And Re-Identification For Mobility Intelligence, Stepan Mazokha

Electronic Theses and Dissertations 2020 - Present

Mobility monitoring in urban environments can provide valuable insights into pedestrian and vehicle movement – where people want to go, how they get there, and the challenges they face along the way. Today, local governments can automate the acquisition of such data using video surveillance to understand the potential impact of investment and policy decisions. However, public disapproval of computer vision due to privacy concerns opens opportunities for research into alternative tools built with privacy constraints at the core of the design. WiFi sensing emerges as a promising solution. Modern mobile devices ubiquitously support the 802.11 standard and regularly emit …

Investigating The Relationship Between School Counseling Site Supervisors’ Characteristics, And Perceived Levels Of Cultural Humility, Advocacy, And Social Determinants Of Health Competencies, Nadiya Boyce-Rosen

Electronic Theses and Dissertations 2020 - Present

This study aimed to understand the relationship between School Counseling Site Supervisors’ (SCSS) characteristics, Social Determinants of Health (SDOH) training, cultural humility, advocacy competency, and SDOH competency (n = 69). SDOH refers to the factors that inform an individual’s physical and mental health. Cultural humility refers to an innate openness and curiosity about individual experiences, perspectives, and culture. Advocacy competency refers to the ability to implement advocacy efforts within an individual’s community. Having competency with addressing SDOH in schools, practicing cultural humility, and advocacy competency can help SCSS improve supervision practice within school communities. This study followed a non-experimental, correlational …

Intergenerational Interchangeable Forms Of Maltreatment Within Families, Katherine Haggar

Electronic Theses and Dissertations 2020 - Present

In 2022, there were about 4,276,000 referrals to Child Protective Service (CPS) agencies within the United States in regard to 7,530,000 children (U.S. Department of Health & Human Services 2024: xii). Of these allegations there are 558,899 victims of child maltreatment (U.S. Department of Health & Human Services 2024: xii). One risk factor for child maltreatment is having a caregiver who has experienced victimization. Although there are many other risk factors for child maltreatment, this research highlights a caregiver having been maltreated and then the type of maltreatment experienced (either physical abuse or sexual abuse) as main areas of study. …

Ipòp Kréyòl: Oraliture And Identity In The French West Indies, Coraline Kandassamy

Electronic Theses and Dissertations 2020 - Present

My research centers around French West Indian hip hop music (also called rap) and identity, from its emergence in the 1980s to its evolution in the ensuing years against the backdrop of the Caribbean Francophone literary traditions, as another musical expression of oraliture. By oraliture, we understand a set of unwritten and oral creations representing an era or a community. The dissertation aims to study the appropriation of hip hop music by local artists in the French West Indies (F.W.I.), in particular focusing on the islands of Guadeloupe and Martinique, because of their geographic, social, political, and cultural settings. Given …

Investigating The Role Of Alternative 3’Utrs In G-Protein Signaling, Oliver Pelletier

Electronic Theses and Dissertations 2020 - Present

The striatum, a region of the brain responsible for motor control and reward processing, plays a critical role in various neurological disorders, including Parkinson's disease, Huntington's disease, and addiction. Gnal encodes the heterotrimeric G-protein stimulatory alpha subunit, Gαolf. Gαolf is highly expressed in the striatum, a brain region that is highly relevant to psychosis and psychostimulant drug action. The Gγ7 protein is also enriched in the striatum, where we have previously shown that Gγ7 protein is required at the posttranscriptional level for the hierarchical assembly of the striatal-specific Gαo lfβ2γ7 heterotrimer, which represents the rate-limiting step for cAMP production in …

Looking Into The Deep: Investigating Micro- And Nanoscale Biomineral Architecture Of Marine Organisms Using Advanced Characterization Techniques, Dawn May Somu Raja

Electronic Theses and Dissertations 2020 - Present

Living organisms synthesize and assemble complex bioinorganic composites with enhanced structure and properties to fulfill needs such as structural support and enhanced mechanical function. With the advent of advanced materials characterization techniques, these biomineral systems can be explored with high resolution to glean information on their composition, ultrastructure, assembly, and biomechanics. In this work, the endoskeletal features of two marine organisms are explored. Acantharia are geographically widespread marine planktonic single-celled organisms. Their star-shaped SrSO4 endoskeleton consists of spicules emanating from a central junction, arranged to satisfy crystallochemical and spatial requirements of their orthorhombic crystal lattice. In this work, synchrotron X-ray …

Macbeth On Screen, Pamela Oldfield

Electronic Theses and Dissertations 2020 - Present

It is the purpose of this thesis to analyze the fresh relevance of Shakespeare’s four-hundred-year-old tragedy Macbeth, as manifested in three contemporary films: Macbeth, directed by Rupert Goold, starring Patrick Stewart (2010); Macbeth, directed by Justin Kurzel, starring Michael Fassbender (2015); and The Tragedy of Macbeth, directed by Joel Coen, starring Denzel Washington (2021). The thesis examines the unique thematic ideas in each adaptation. The directors have distinct visions. Goold imagines Macbeth as a Stalinesque authoritarian. Kurzel’s Macbeth battles post-traumatic stress disorder. Coen’s older Macbeth is desperate to attain the status he is adamant he has earned, obsessed with the …

Marine Microbial Interactions: A Tale Of Two Cities, Jackie Lin Palau

Electronic Theses and Dissertations 2020 - Present

Microbial partners provide beneficial and detrimental functions to their hosts and other microbes through the exchange of metabolites and info chemicals. Developing an understanding of these micro-interactions has considerable implications for human health, agriculture, and ecosystem protection. Here, the microbial interactions of two important marine organisms: the Forcepia sp. sponge, a source of the potential anticancer compound, lasonolide A (LSA), and Pyrodinium bahamense, a dinoflagellate which produces the potent neurotoxin, saxitoxin, were investigated. Chapter 1 introduces marine microbial interactions, their importance in the function of organisms and ecosystems, and their applications in human health, agriculture and ecosystem production. Chapter 2 …

Multiphysics Simulation Of Dielectrophoresis Enrichment For Detection Of Low Parasitemia Plasmodium Falciparum In Human Blood, Oladiran Oladokun

Electronic Theses and Dissertations 2020 - Present

Malaria is an ancient lethargic disease that remains a global burden. It has been difficult to end the scourge of P. falciparum malaria because of the parasites’ drug resistance so early diagnosis of malaria is crucial. Microscopy remains the gold standard but has limited reliability in detecting malaria parasites. This study proffered a method towards detection of low parasitemia P. falciparum infected RBCs (Pf-RBCs) based on dielectrophoresis (DEP). A microfluidic device was designed for label-free cell sorting of Pf-RBCs from other whole blood in a continuous manner, based on the intrinsic electrical signatures of the cells. The design was validated …

Nanoparticle-Induced Catalytic Carbon Capture: A Microfluidics Approach, Joshua Donjuan

Electronic Theses and Dissertations 2020 - Present

Due to technological advancement, energy consumption and demand have been increasing significantly, primarily satisfied by fossil fuel consumption. This reliance on fossil fuels results in substantial greenhouse gas emissions, with CO₂ being the most prominent contributor to global warming. To mitigate this issue and prevent CO₂ emissions, Carbon Capture, Utilization, and Storage (CCUS) technologies are employed. Among these, the amine scrubbing method is widely used due to its high CO2 capture efficiency and regenerative ability. However, this method has drawbacks, including high toxicity, corrosion, and substantial freshwater consumption. To develop an environmentally sustainable carbon capture solution, researchers are exploring alternatives …

Operational Association Of New Institutionalism By Semiotic Comparison Of Organizational Abbreviated Communications Through Natural Language Processing, Benjamin E. Trautman

Electronic Theses and Dissertations 2020 - Present

The link between organizational theory and its application in practice is explored in this research through the lens of Peircian semiotics. An investigation is conducted of how organizations convey their culture through mission and vision statements and the reflection of these statements within New Institutionalism. Through the use of a novel computational model that merges quantitative analysis with traditional qualitative methods, this study evaluates the relevance and effectiveness of institutional theories. The three main schools of New Institutionalism—rational choice, historical, and sociological institutionalism —are examined to determine how well municipal mission and vision statements align with the theories' principles. The …

Pandemic Perspectives: The Influence Of Disaster Experience And Technology Use Over The Life Course On Covid-19 Perception And Response Among Older Adults, Jordanne Kessel

Electronic Theses and Dissertations 2020 - Present

No group was more physically vulnerable to the COVID-19 pandemic than older adults. However, differing life histories and structural realities make for widely varying pandemic experiences. Using a life course approach, this study situates the COVID-19 pandemic and use of communication tools into context of older adults’ life experience with disasters and technology. Merging the scholarly fields of disaster sociology and aging studies, the purpose of this research is to find how life course experience and technology use impacted older adults’ perception of, and response to, COVID-19. Accordingly, I ask how does previous disaster experience and technology usage influence older …

Perceived Network Responsiveness As A Moderator Of The Effects Of Social Media Use On Wellbeing, Angalee Wilson

Electronic Theses and Dissertations 2020 - Present

Social media’s role in daily life is on the rise, but as social media use increases, so do questions about its potential benefits or harms. This set of studies examined the relationship between social media use, wellbeing, and perceived network responsiveness, a measure of an individual’s perception about the degree to which their online social networks are caring, validating, and understanding. Two pre-registered correlational studies which employed surveys of undergraduate students (Study 1a: N = 218, Study 1b: N = 179) found that perceived network responsiveness was positively correlated with life satisfaction and negatively correlated with loneliness. A pre-registered experimental …

Political Reforms And Women’S Rights In The Kingdom Of Saudi Arabia, Sama Khalil Abuhasabo

Electronic Theses and Dissertations 2020 - Present

The Arabian Peninsula was under the influence of the Ottoman Empire from 1517 until its collapse in 1918. During this time, three attempts were made to establish a Saudi state, the last of which began in 1902 and ended with the unification of the third Saudi State in 1932. During this period, three Saudi States were formed. The first Saudi State was established in 1745 when the al-Diriyah Agreement was introduced. This landmark agreement was achieved when Imam Mohammed Ibn Saud formed an alliance with Sheikh Mohammed Ibn Abdul Wahhab, a religious and rebellious man who advocated for the pure …

Real Earnings Management Effect On Customer Service And Service Quality, Brett Powers

Electronic Theses and Dissertations 2020 - Present

I investigate the link between real earnings management and customer satisfaction. Following the passing of the Sarbanes-Oxley Act, which requires public companies to ensure the accuracy of their financial reporting, the use of non-accrual based methods to achieve financial earnings targets has become commonplace. Nonaccrual-based methods consist of decisions that curtail firm activities, which increase net income; however, these methods come at the cost of future operations. These opportunistic behaviors in the service, retail, and hospitality industries impact customers and a firm's long-term value. I hypothesize that the outcome will be lower customer satisfaction and service quality. I use firms’ …

Regional Social Capital And Backer Sentiment For Successful Crowdfunding Campaigns, Joseph Grimes

Electronic Theses and Dissertations 2020 - Present

Local social capital, defined as the level of community interaction and social participation of a region, has been theorized to positively affect economic outcomes and discourage opportunistic behaviors in various settings. I examine whether local social capital is related to positive outcomes for entrepreneurs and their financial backers in the settings of reward crowdfunding and small business lending. In my first study, I look at how local social capital influences the creators of successful reward crowdfunding campaigns. These creators, in turn, may influence the sentiment of their investors, or backers, towards their projects through missed delivery deadlines and poor communication. …

Reusing And Recording: The Past And Future Survival Of The Jupiter Inlet Light Station Radio Beacon Building, Hailie Crowder

Electronic Theses and Dissertations 2020 - Present

For much of the 20th century, mariners in the United States were able to utilize the radio beacon system to aid in navigation; however, in spite of its importance in U.S. nautical history, there has been very little historical or archaeological research published about the system. The Jupiter Inlet Light Station Radio Beacon Building, located at what is today known as the Jupiter Inlet Lighthouse Outstanding Natural Area (JILONA), was part of this coastal network of radio beacons. This thesis involves the methodologies of historical research and terrestrial laser scanning and serves several purposes: to provide JILONA with information about …