Digital Commons Network^™

African American Males In Rural Elementary Schools During The Pandemic: Experiences, Challenges, And Strategies For Success, Jessica Lewis

All Dissertations

The present study experimentally examined the impact of the COVID-19 pandemic on elementary African American males living in rural areas. The qualitative study used a phenomenological approach to examine students' perspectives, as understood by the parents and educators (N=10). Using semi-structured interviews and thematic coding, the researcher suggested strategies for successfully closing instructional gaps and meeting the needs of this population moving forward.

The theoretical frameworks that triggered this exploration were Intersectionality, Maslow’s Hierarchy of Needs, and Conflict Theory. The researcher used the theories as a lens to answer the following research questions: (1) How much has COVID-19 revealed the …

Imipridones Inhibit Tumor Growth And Improve Survival In An Orthotopic Liver Metastasis Mouse Model Of Human Uveal Melanoma, Chandrani Chattopadhyay, Janos Roszik, Rajat Bhattacharya, Md Alauddin, Iqbal Mahmud, Sirisha Yadugiri, Mir Mustafa Ali, Fatima S Khan, Varun Vijay Prabhu, Philip L Lorenzi, Bo Wei, Elizabeth Burton, Rohini R Morey, Rossana Lazcano, Michael A Davies, Sapna P Patel, Elizabeth A Grimm

Faculty, Staff and Student Publications

Background: Uveal melanoma (UM) is a highly aggressive disease with very few treatment options. We previously demonstrated that mUM is characterized by high oxidative phosphorylation (OXPHOS). Here we tested the anti-tumor, signaling and metabolic effects of imipridones, which are CLPP activators, which inhibit OXPHOS indirectly and have demonstrated safety in patients.

Methods: We assessed CLPP expression in UM patient samples. We tested the effects of imipridones (ONC201 and ONC212) on the growth, survival, signaling and metabolism of UM cell lines in vitro, and for therapeutic efficacy in vivo in UM liver metastasis models.

Results: CLPP expression was detected in primary …

Anti-Programmed Death Ligand 1 Plus Targeted Therapy In Anaplastic Thyroid Carcinoma: A Nonrandomized Clinical Trial, Maria E Cabanillas, Ramona Dadu, Renata Ferrarotto, Maria Gule-Monroe, Suyu Liu, Bryan Fellman, Michelle D Williams, Mark Zafereo, Jennifer R Wang, Charles Lu, Matthew Ning, Brian A Mckinley, Scott E Woodman, Dzifa Duose, Gary B Gunn, Naifa L Busaidy, Rare Tumor Initiative Team

Faculty, Staff and Student Publications

Importance: Anaplastic thyroid carcinoma (ATC) is a rare and lethal cancer. Although progress has been made in recent years in patients with mutated BRAF tumors, those who respond initially eventually die of their disease; furthermore, there are no approved therapies for non-BRAF mutated tumors.

Objective: To determine whether treatment with matched-targeted therapy plus immune checkpoint inhibitors were associated with improved overall survival (OS).

Design, setting, and participants: A phase 2 trial at a single center, tertiary institution with parallel cohorts, assigning treatment with targeted therapy according to the tumor mutation status. Patients with mutated BRAF V600E tumors received vemurafenib/cobimetinib plus …

Explainable Artificial Intelligence And Domain Adaptation For Predicting Hiv Infection With Graph Neural Networks, Evan Yu, Jingcheng Du, Yang Xiang, Xinyue Hu, Jingna Feng, Xi Luo, John A Schneider, Degui Zhi, Kayo Fujimoto, Cui Tao

Faculty, Staff and Student Publications

OBJECTIVE: Investigation of explainable deep learning methods for graph neural networks to predict HIV infections with social network information and performing domain adaptation to evaluate model transferability across different datasets.

METHODS: Network data from two cohorts of younger sexual minority men (SMM) from two U.S. cities (Chicago, IL, and Houston, TX) were collected between 2014 and 2016. Feature importance from graph attention network (GAT) models were determined using GNNExplainer. Domain adaptation was performed to examine model transferability from one city dataset to the other dataset, training with 100% of the source dataset with 30% of the target dataset and prediction …

Healthcare Disparities, Screening, And Molecular Testing In The Changing Landscape Of Non-Small Cell Lung Cancer In The United States: A Review, Razelle Kurzrock, Aadel A Chaudhuri, David Feller-Kopman, Narjust Florez, Jed Gorden, Ignacio I Wistuba

Faculty, Staff and Student Publications

Inequitable access to care continues to hinder improvements in diagnosis and treatment of lung cancer. This review describes healthcare disparities in the changing landscape of non-small cell lung cancer (NSCLC) in the United States, focusing on racial, ethnic, sex-based, and socioeconomic trends. Furthermore, strategies to address disparities, overcome challenges, and improve patient outcomes are proposed. Barriers exist across lung cancer screening, diagnosis, and treatment regimens, varying by sex, age, race and ethnicity, geography, and socioeconomic status. Incidence and mortality rates of lung cancer are higher among Black men than White men, and incidences in young women are substantially greater than …

Student Misbehaviors, University Instructors’’ Mental Health, And Trauma Management: A Phenomenological Study, Abdul Karim, Bineeta Rahman, Muhammad Kamarul Kabilan

The Qualitative Report

The present study aimed to unpack student misbehaviors that instructors face inside the university campus. It also intended to unfold how student misbehaviors affect instructors’ mental health and how they overcome the trauma engendered by student misbehaviors. Adopting a phenomenological approach, we explored the phenomenon to answer the research questions by conducting semi-structured interviews with six teachers. Through a thematic analysis, we found that university instructors experience various misbehaviors presented by students inside the university campus, and as a result, their mental health suffers. However, instructors tend to ignore their mental health and focus on academic activities to overcome the …

Food At Sea On The Late Antique Mediterranean, Andrew Donnelly, Justin Leidwanger

Faculty Publications

No abstract provided.

At-Risk And Online: Parent Perceptions Of At-Risk Learner's Supports In A Fully Online School, Dennis Beck

Curriculum and Instruction Faculty Publications and Presentations

At-risk students face a variety of challenges that encompass cultural, social and environmental contexts and identities. Full time virtual schools offer help for at-risk students through the provision of a personalized learning option where students can catch up with past work or complete school work in a non-traditional environment. The purpose of this study was to understand parent perceptions of at-risk learner’s affective, behavioral, and cognitive engagement supports in a fully online school. Although research exists on at-risk learners in blended environments, this topic has not yet been fully explored for fully online schools. We need a much fuller understanding …

Issue 41

The Synapse: Intercollegiate science magazine

No abstract provided.

On A Color Wheel: Adhd Under The Social Model's Scope, Ben Tran

The Synapse: Intercollegiate science magazine

No abstract provided.

Filtered Reality: Artificial Intelligence In Social Media & The Mental Health Of Adolescents, Maria Savva

Open Educational Resources

This instructional module was developed for teacher candidates preparing to teach in New York secondary schools, which include middle (6-8) and high schools (9-12). A three-pronged approach has been used to ensure teacher candidates develop a comprehensive and contemporary understanding of Artificial Intelligence (AI) as it relates both to their respective disciplines and its impact on the adolescents they will be teaching. Using a three-pronged approach, teacher candidates will: consider the rapidly changing landscape of their own discipline and how it has been impacted by developments in AI; examine the effects of AI, including through social media platforms, on the …

Chronic Illness Education 2024: A Guide To Navigating Chronic Obstructive Pulmonary Disease, Polina Chuikov, Bilal Ahmed, Brennan Smith, Karina Medina, Masoud Harati

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Diet And Excersize Education To Improve Adult Obesity, David Elyas, Dhwani Krishnan, Joseph Overway, Melissa Connop, Swathi Srikantan, Zahira Malik

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Evaluating Psychological Barriers To Treating Cardiovascular Disease, Ameen Khan, Aria Hutchinson, Caitlin Ann Benitez, Daniel Poe, Dawson Sloan, Shivani Bongu

Patient Education Projects

No abstract provided.

Chronic Illness Education 2024: Resources To Improve Childhood Anxiety, Ananya Yanamandra, Danny Salka, Hamza Khan, Julie Waineo, Karen Zapien-Guerra

Patient Education Projects

No abstract provided.

Predictors Of Belongingness In First-Year College Students: Examining Mental Health And Adjustment, Jordan D. Foreman-Black

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

The initial transition to college is a pivotal moment for emerging adults, often influencing whether a student will remain successful. Students face a significant challenge adapting to the new environment that has been compounded by their experiences through the COVID-19 pandemic. Despite these challenges, a sense of belonging for students has been shown to be a key aspect of a successful transition to college. Students are often confronted with increasing levels of mental health challenges throughout the transition, specifically experiencing increasing mental health difficulties or challenges throughout their initial adjustment to college. Moreover, parents have become increasingly involved in students’ …

Argument Schema Of Undergraduate Engineering Students, Anu Singh

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

Critical thinking is one of the most desired skills in the workplace, as it assists an individual in solving complex problems and making informed decisions, resulting in their workplace success. Argumentation is one instructional approach that provides students an opportunity to engage in higher-order thinking and improve their communication skills. Argumentative writing provides opportunities to engage in multiple perspectives of a problem, provide evidence for the claim, evaluate evidence, engage in reasoning, and acknowledge self-bias, which automatically engages students in critical thinking. Previous literature has shown that despite the use of interventions and scaffolding approaches, students' argumentative texts lack elements …

Socio-Ecological Drivers Of Anthropogenic Marine Debris Effects On Coral Reef Communities In The Florida Keys, Usa, Tokea Payton

All Dissertations

The Florida Keys reef tract has rapidly shifted from a structurally complex, hard coral-dominated reef to a less rugose, soft coral-dominated reef. Persistent anthropogenic stressors facilitate ecological transitions by including recreational and commercial fishing and increased anthropogenic marine debris. These artificial structures are becoming habitats for small marine taxa known as cryptofauna. Cryptofauna are among the most essential yet understudied reef taxa where little is known about their fate considering degrading coral reefs and increasing anthropogenic disturbance. With increased anthropogenic stressors on the marine environment, the SCUBA diving community has initiated extensive marine debris removal efforts to assist in cleaning …

An Exploration Of The Role Of The Disorienting Dilemma In Professional Learning For Academic Library Instructors, Anne Grant

All Dissertations

This study uses an explanatory sequential mixed method design to understand more about the learning experiences of academic library instructors from 2- and 4-year institutions during a professional development session centered on using Universal Design for Learning. Transformative Learning Theory served as the lens to examine data, and the concept of a disorienting dilemma that serves as a trigger for deep learning in adults. The experiences of the participants are explained using data from a pre- and post-survey as well as semi-structured interviews with participants to learn more about factors that may predict whether or not participants experience a disorienting …

Agricultural Water Use In South Carolina - A Series Of Investigations To Support Long-Term Planning, Charles Pellett

All Dissertations

Agricultural water use in South Carolina has been the subject of some public debate. While there are several sources of information available, the accuracy of the relevant data has been called into doubt. Self-reported estimates may be biased; survey sampling and extrapolation methods yield wide ranges of uncertainty; and reporting compliance or response rate can change over time.

Agricultural water users self-report that their estimates of water use volumes are less accurate than the other major sectors of water use. Center pivot irrigation is the largest and fastest growing kind of agricultural water use in SC. Since the year 2000, …

Investigating The Role Of Cd44 In Her2+ Breast Cancer Cells During Cancer Cell Redirection, Holly Caroline Jordan Campbell

All Dissertations

Despite a rise in survival rates of breast cancer patients due to advances in modern medicine, breast cancer is the most common type of cancer in women and is the second leading cause of cancer death in the United States. Early detection and a more personalized treatment of breast cancer has slowly improved patient outcomes. Nevertheless, there are impediments to better patient outcomes due to the complexity of the disease physiology. Therefore, there is a demand for a comprehensive understanding of cancer development as well as a need to understand tumor progression for enhanced therapies for patients.

Previous in vivo …

The Lived Experiences Of Women In Construction: Career Supporting Strategies, Cheryl Anne Loar Croall

Electronic Theses and Dissertations

Women are underrepresented in the United States construction industry, representing only 11% of the workforce, and this lack of diversity in the male-dominated occupation results in barriers to female career advancement. The problem is that women in construction experience obstacles to career progression due to gender work life balance, sexual harassment, and pay inequality; barriers such as these keep women out of leadership roles. Three recommended techniques to support women’s career progression in construction and combat barriers to career advancement include social support, fighting back (openly challenging discrimination), and positive reappraisal (reframing negatives to positives). Understanding the effectiveness of these …

Constitutive Chefs: The Ethos And Constitutive Rhetoric Of Anthony Bourdain, Sean Sherman, And Mashama Bailey., Michael Jared Benjamin

Electronic Theses and Dissertations

This dissertation project explores the motivation of chefs to become Public Chef Intellectuals and how they cultivate and engage with an audience that will never taste their food. Using a case study approach, this dissertation analyzes the intellectual missions of Anthony Bourdain, Sean Sherman, and Mahsama Bailey as told through their television shows, memoirs, cookbooks, and restaurant menus. I argue that for each chef, their cultural identity is inextricably tied to their ultimate purpose – the use of food as a Trojan horse to promote their vision for a collective American culture. This project underscores that this process happens dialogically …

Brief Of First Amendment And Internet Law Professors As Amici Curiae In Support Of Petitioners, Tiktok Inc. V. Garland, No. 24-656 (U.S. 2025)., Shubhangi Agarwalla, Enrique Armijo, Kevin Bankston, Susan Benesch, Ashutosh Bhagwat, Stuart N. Brotman, Ryan Calo, Anupam Chander, Erwin Chemerinsky, Alan K. Chen, David Craig, Eric Goldman, Gregory Gondwe, James Grimmelmann, Nikolas Guggenberger, G.S. Hans, Robert A. Heverly, Thomas E. Kadri, David Kaye, Heidi Kitrosser, Vivek Krishnamurthy, Edward Lee, Mark A. Lemley, David S. Levine, Yvette Joy Liebesman, Gregory P. Magarian, Jess Miers, Sean O’Brien, Mary-Rose Papandrea, Kermit Roosevelt, Jennifer Safstrom, Pamela Samuelson, Madhavi Sunder, Christopher Jon Sprigman, Jordi Weinstock

Con Law Center Amicus Briefs

“Without freedom of thought, there can be no such thing as wisdom, and no such thing as public liberty, without freedom of speech.” Benjamin Franklin, Silence Dogwood, No. 8 (July 9, 1722). For this reason, the U.S. Constitution makes clear that the Government cannot abridge free speech based on its content or viewpoint absent compelling and narrowly tailored grounds. Indeed, the protection of all speech is foundational to American democracy. See United States v. Schwimmer, 279 U.S. 644, 654–55 (1929) (Holmes, J., dissenting) (“[I]f there is any principle of the Constitution that more imperatively calls for attachment than any other …

Extracting Permittivity And Permeability Using The Position-Insensitive And Calibration-Independent Method On A Rectangular Waveguide, James Conrad Denemark

Theses and Dissertations

Classic methods for extracting material characteristics require known measurements to accurately calibrate the network analyzer. Previous work demonstrated a position-insensitive and calibration-independent (PiCi) transmission/reflection method to extract a material’s permittivity. This thesis proposes a method with the same function, manipulated to use one empty measurement and then two samples of different thicknesses. The PiCi method is first adopted for rectangular waveguide which resulted in inaccurate permittivity data when compared to the calibrated solution. Once detector mismatch corrections were applied, the PiCi method produced accurate results. Using a 2-D numerical root search, permittivity and permeability material characteristics are now successfully extracted …

Empowering Community Health Promoters For Healthy Births In Sega, Kenya, Melissa Castro, Trang Ha, Dominique Tagupa, Kaliah Vang

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Promoting Mental Health For Graduate Students: The Mind Matters Initiative, Kelly Donahoe, Marissa Marchman, Anna Ramos, Silvia Reyes

ELMSN E-Portfolio. A collection of Scholarly and Creative Works

No abstract provided.

Epistemic Spaces And Fields: A New Framework For Social Epistemology Applied To The Internet, Zizhe Cheng

Honors Theses

This thesis introduces "Epistemic Spaces and Fields," a novel framework for social epistemology inspired by the analogies of space and fields in physics to better elucidate how epistemic environments shape epistemic practices. Part A establishes the theoretical underpinnings of epistemic spaces and fields, demonstrating how social, cultural , and power dynamics distort individuals' capacities to obtain and communicate knowledge. Part B applies this framework to the digital realm, examining how the Internet and social media reshape our epistemic contexts and introduce new challenges to critical thinking.

Wills, Trusts, And Estates, Allison A. Tait, Hunter M. Glenn

University of Richmond Law Review

This year could be considered quiet in both legislative and judicial activity, lacking as it was in any substantial new legislative enactments or major opinions from the Supreme Court of Virginia on core wealth transfer issues. Nevertheless, a set of modest legislative changes helped bring the rules for revocable trusts in line with the rules for wills, standardizing estate planning and wealth transfer regulation, while other changes also brought clarity to existing rules by amplifying procedures and providing additional de- tail for administrative processes. In the judicial setting, while guidance for this practice area was primarily provided by the Court …

Pixels Of Passion: The Revolutionary Impact Of Indie Games, Sharanya Udupa

ART 108: Introduction to Games Studies

In the dynamic world of video game development, a powerful revolution has been quietly transforming how interactive experiences are created. Independent game developers, or "indie" game creators, have emerged as innovative storytellers and design pioneers, challenging traditional gaming paradigms and offering players unique, personal experiences that transcend mainstream entertainment.

Unlike mainstream games developed by large corporations with multi-million dollar budgets, indie games are typically created by small teams or even individual developers driven by artistic vision rather than pure commercial interests. These creators prioritize innovative gameplay mechanics, compelling narratives, and unique aesthetic experiences over conventional market formulas. Platforms like Steam …