Digital Commons Network^™

After Further Review: Are Ncaa Conferences Now Subject To Antitrust Liability?, Madison Huberman

Brooklyn Journal of Corporate, Financial & Commercial Law

Following the Alston decision, the landscape of college athletics has undergone significant transformation. Although the Supreme Court in Alston previously determined that individual conferences lacked power over the relevant market, this is no longer true for all conferences. This note explores the potential antitrust liability facing individual NCAA conferences in the post-Alston era. It reviews the NCAA’s historical context, its member institutions, and the variations in membership across Divisions and sports. The analysis then shifts to the current state of college athletics, including NIL policies, conference realignment, and media rights deals. The note further assesses whether certain conferences are susceptible …

The Role Of Lifr Signaling In Innate Immunity, Laura Kahn Serrudo

Dissertations and Theses (Open Access)

The localized signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory cytokines, and differentiation into monocyte-derived dendritic cells (MoDCs), which are required for efficient pathogen eradication.

Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in …

Oncolytic Viruses Enhance Long-Term Nk Cell Anti-Tumor Cytotoxicity Through Ap-1 And Irf Pathway Activation, Xin Ru Jiang

Dissertations and Theses (Open Access)

Natural killer (NK) cell therapeutics have emerged as a promising strategy in adoptive cellular therapy. While genetic modifications of NK cells can enhance their antitumor activity, modulating the tumor to augment NK cell recognition and function remains underexplored. In this study, we investigated the combination of NK cells with oncolytic viruses to treat solid tumors, specifically pancreatic ductal adenocarcinoma and glioblastoma. We demonstrated that infecting tumor cells with the oncolytic adenovirus Delta-24-RGD significantly increases their susceptibility to NK cell cytotoxicity, driven by a hyperactivated NK cell phenotype characterized by elevated expression of activating receptors and cytotoxicity markers. In a patient-derived …

Local Or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes And Downregulates C-Myc Oncoprotein, Akash Boda

Dissertations and Theses (Open Access)

The past decade has witnessed remarkable advances in the field of cancer immunotherapy. Immune checkpoint blockade (ICB) has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor types. Immunologically "cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC), remain clinically unresponsive to ICB, presenting a significant challenge in oncology. Amidst these challenges, the stimulation of the STING pathway via small molecule synthetic agonists has surfaced as a promising strategy. Acting as an in-situ vaccine, STING activation has the potential to transform the immune landscape of cold tumors …

Associations Between Metabolic Disorders And Sjögren’S Disease, Chihiro Iwaya, Junichi Iwata

Faculty, Staff and Student Publications

Sjögren’s disease (SjD) is a systemic autoimmune disorder characterized by dry eyes and mouth caused by chronic inflammation and is often accompanied by various extra-glandular manifestations, including fatigue and diffuse pain. Although the pathogenesis of the disease remains elusive, several factors (e.g. environmental, genetic and hormonal factors, abnormal metabolic status) are associated with this condition. Accumulating evidence suggests a potential role of cholesterol metabolism in immune and non-immune modulation in various diseases. In this review, we summarize the current findings on the associations between cholesterol metabolism and SjD.

Hpv Vaccine-Related Articles Shared On Facebook From 2019 To 2021: Did Covid Make A Difference?, L Aubree Shay, Ashley Mckenzie, Elaine Avshman, Lara S Savas, Ross Shegog

Faculty, Staff and Student Publications

OBJECTIVE: HPV vaccination is recommended for children beginning at age 9 to prevent several types of cancer. Many parents turn to Facebook for health information. This study describes changes in HPV vaccine-related articles shared on Facebook amidst the COVID-19 pandemic.

METHODS: HPV-related articles shared on Facebook (2019-2021) were collected using Buzzsumo, a social media analytics tool and analyzed using content analysis. Articles were categorized by valence, misinformation, evidence types, persuasive tactics, and framing. We quantified these data and tested for difference by article year.

RESULTS: Of the 138 included articles, 51% had positive valence towards the vaccine and 36% had …

The Role Of Ganglioside Gd2 And Gd3 Synthase (St8sia1) In The Regulation Of Immune Suppression In Breast Cancer, Bolutyfe Oderinde

Dissertations and Theses (Open Access)

Gangliosides are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key enzyme that regulates the biosynthesis of the b and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors and plays a role in tumor progression. Similarly, we have previously found GD3S to be significantly upregulated in GD2+ breast cancer stem cells (BCSC) compared to GD2- cells, and the knockdown of …

The Unconscious At Work: A Psychosocial Study Of Leaders' Unconscious Processes Impacting Participatory Change Leadership, Vanessa Hills

Dissertations

This dissertation explores the varied dynamics impacting how organizational leaders conceptualize and enact their roles in participatory change processes. To that end, a multiple-case study informed by a psycho-social approach and using Free Association Narrative Interview (FANI) methods was conducted. Each case was comprised of a single business leader. The findings, presented through individual case analyses and cross-case comparisons, reveal a discrepancy between leaders’ rhetoric and the reality of their change leadership behaviors. While leaders express support for collaborative change, factors such as a desire for control, fear of failure, and bias toward their own capabilities lead them to adopt …

El Leñador, December 2024, El Leñador Staff

El Leñador Newspaper

El Leñador is an English and Spanish newspaper produced by Humboldt State University students. Our staff cover and provide news to Latinx and other diverse communities on campus and in Humboldt County. We are committed to providing relevant news and expanding the representations and stories told about people of color and other marginalized groups. Our work helps create more social, political and cultural diversity in local media.

El Leñador es un periodico en español y inglés producido por estudiantes de la Universidad Estatal de Humboldt. Nuestro personal cubre y provee noticias a la comunidad Latinx y otras comunidades diversas en …

The Life And Discoveries Of Yellapragada Subbarow, Nikhil R, Varuni Pragya, Subramanian Ramaswamy, Shiva Prasad B N, Mahabaleshwar Mamadapur

Digital Journal of Clinical Medicine

Dr. Yellapragada Subbarow was a researcher, teacher, and a wizard of wonder drugs who constantly made efforts in the discoveries/ inventions such as vitamins, anti-vitamins, antibiotics, and many more by disentangling the mysteries of nature for the betterment of the people. He inspired the youngsters to take up the challenges and to stand up above mediocrity. The reward for his achievement was delayed. The article describes a true humanist's journey, discoveries, and his achievements that are largely unknown to date.

Understanding Global Street Food Consumer Behavior And Experience: A Narrative Review Of Literature And Development Of Framework, Samit Chakravorti

Journal of Applied Marketing Theory

This paper explores global street food consumer behavior and consumption experience. The aim of this paper is to gain a holistic comprehension of street food consumption decision making and experience through exploring nature and sources of perceptions, attitude and expectations surrounding street food, the characteristics of the product offering and the domain within which it is served and consumed. To achieve this aim the author engages in a narrative review of academic research on consumer behavior of street food, provides a holistic picture of consumption experience of street food through consolidating and interpreting research findings, and extends the theoretical understanding …

Measuring Social Influence In Online Social Networks - Focused Literature Review On Human Behaviors, Shyamala N. Chalakudi, Gnana Bharathy, Dildar Hussain, Dakshinamurthy Kolluru

Journal of Applied Marketing Theory

Measuring an individual's social influence (SI) capability is gaining traction with the rapid growth and expansive reach of online social networks (OSN). However, most existing frameworks and methods are confined to graphical theories or the structural properties of these networks. Even behavioral investigations are often limited to a narrow set of influencing behaviors and confront significant challenges in encompassing the breadth of human psychological characteristics. This study aims to address this gap through an exhaustive and focused literature review, concentrating on the definitions of human behavior characteristics rooted in established sociology and psychology theories. Beyond providing a comprehensive overview, the …

Sorry Not Sorry: Presentational Strategies And The Electoral Punishment Of Corruption, Dean C. Dulay, Seulki Lee

Research Collection School of Social Sciences

A growing literature has explored various factors that hamper the electoral punishment of corruption. Most studies have focused on how voters react to a corruption allegation, but this focus leaves out an important, common aspect of corruption allegations that voters also encounter: politicians' blame avoidance strategies. This study examines how politicians' presentational strategies in response to corruption allegations affect voter sanctioning. Employing an online survey experiment on a sample of 3531 U.S. citizens, we find that politicians' action-oriented strategies, such as denying allegations, acknowledging a problem but denying responsibility, or acknowledging a problem and taking responsibility, are more effective than …

Rate Coefficients For Rotational State-To-State Transitions In H2O + H2 Collisions As Predicted By Mixed Quantum–Classical Theory, Carolin Joy, Dulat Bostan, Bikramaditya Mandal, Dmitri Babikov

Chemistry Faculty Research and Publications

Aims. A new dataset of collisional rate coefficients for transitions between the rotational states of H₂O collided with H₂ background gas is developed. The goal is to expand over the other existing datasets in terms of the rotational states of water (200 states are included here) and the rotational states of hydrogen (10 states). All four symmetries of ortho- and para-water combined with ortho- and para-hydrogen are considered.

Methods. The mixed quantum–classical theory of inelastic scattering implemented in the code MQCT was employed. A detailed comparison with previous datasets was conducted to ensure that this …

The Lasting Psychological Effects Of Juvenile Arrests, Nadia Olivia Bortolin

Theses and Dissertations

This research investigated the enduring psychological consequences, specifically depression and anxiety, stemming from juvenile arrests and their influence on adulthood. Literature has demonstrated impacts on juvenile arrests from cultural, socioeconomic, family dynamics, and environmental elements. This study addresses a notable gap in understanding the long-term impact on mental health and employment. Research indicates a sensitivity to outcomes based on the age of arrest, with early adolescent arrests having profound effects on development and an increased likelihood of subsequent criminal activities. Developmental and risk factors, such as socioeconomic challenges and pubescent difficulties, contribute to persistent delinquent behaviors into adulthood. Some studies …

Malicious Compliance: Examining Revenge Behaviors In Organizations, Patricia Jewel Emily Morrison

Theses and Dissertations

Revenge is a multifaceted behavior that manifests in various forms. The purpose of this dissertation was to examine a particular form of revenge known as malicious compliance, which has yet to be sufficiently researched. A two-study approach was used to examine malicious compliance. In the first study, qualitative data was collected from an online forum for sharing malicious compliance experiences. In the second study, 352 participants completed a mixed-methods survey online. Data from both studies was analyzed in RStudio and MAXQDA. Study 1 utilized unsupervised machine learning techniques, non-machine learning techniques, and thematic coding techniques to analyze the forum dataset. …

The Design And Implementation Of A Modular Tissue Engineering Test Bed To Pursue An Alternate Pathway Of Cell Culture Based Research, Ryley Patrick Griffin

Theses and Dissertations

The development of a Modular Automated Tissue Engineering Test Bed (MATETB) is the next step in the development of cheap and easily available in vitro cell regulatory systems for both academic and industrial purposes. This project outlined the framework and requirements for a device that could automatically regulate and collect data on a cell culture through the manipulation of its liquid environment. From this framework, a prototype was built. The device would fulfill cell culture needs while collecting data automatically and allowing for live viewing and imaging of cells. The device was comprised of a mechanical skeleton (MS), an environmental …

An Exploration Of The Intersections Of The Science Of Reading And Culturally Sustaining Pedagogies: A Constructivist Grounded Theory Study Of Preservice Teachers’ Practice With Teaching Reading Comprehension, Elizabeth Kittleman

Theses and Dissertations

This study explores the possibilities and tensions that emerged when preservice teachers integrated both the science of reading and a culturally sustaining framework when learning about and teaching reading comprehension. Utilizing a constructivist grounded theory methodology, this research draws on data from interviews, student coursework samples, and a researcher journal collected over the course of a semester. During data analysis, four emergent themes were constructed: managing the multiple realities of teaching reading, leveraging background knowledge, navigating biculturalism and inequities, and negotiating a teacher’s role. Findings illustrate the complex relationship between theory and practice when preservice teachers draw on students’ linguistic …

Fabrication And Charcaterization Of Pullulan-Collagen Nanofibers Via Forcespinning, Valeria Leon Leal

Theses and Dissertations

Extensive research on collagen has spurred advancements in tissue engineering and biomaterial development, given collagen´s pivotal role in regulating various tissue structures across diverse organisms. This study delves into fabricating nanocomposites utilizing collagen, along with silver nanoparticles, chondroitin sulfate and pullulan, for potential applications in antibacterial medical devices, and cell regeneration. Collagen, abundant in the extracellular matrix, provides essential structural support, while silver nanoparticles and chondroitin confer antimicrobial properties, crucial for combating infections. Pullulan, a polysaccharide polymer, serves as a biocompatible carrier for silver nanoparticles whilst being the starting nanofiber forming material. Utilizing Forcespinning® technology, composite nanofibers were successfully synthesized. …

Exploring The Potential Of Epiregulin And Amphiregulin As Prognostic, Predictive, And Therapeutic Targets In Colorectal Cancer, Cara Guernsey-Biddle, Peyton High, Kendra S Carmon

The Brown Foundation: Institute of Molecular Medicine

The epidermal growth factor receptor (EGFR) plays a critical role in regulating essential cellular processes that are frequently hijacked to promote cancer. In colorectal cancer (CRC) in particular, the EGFR signaling pathway is frequently hyperactivated via receptor and/or ligand overexpression and downstream oncogenic mutations. Current EGFR-targeted therapies for metastatic CRC (mCRC) include the monoclonal antibodies (mAbs) cetuximab and panitumumab. However, intrinsic and acquired resistance to EGFR-targeted mAbs are commonly observed. Thus, additional biomarkers are necessary to better understand patient sensitivity to EGFR-targeted therapies. Furthermore, therapeutic targeting of alternative EGFR pathway components may serve as one mechanism to overcome EGFR-targeted mAb …

An Update On Novel Taxa And Revised Taxonomic Status Of Bacteria Isolated From Domestic Companion And Agricultural Animals Described In 2023, Sara D. Lawhon, Claire R. Burbick, Trinity Kreuger, Elena Ruiz-Reyes, Erik Munson

Clinical Lab Sciences Faculty Research and Publications

With the proliferation of abundant bacterial genomic data comes the recognition of new organisms as well as a better understanding of the relatedness of known bacteria. Recognizing the associated taxonomic changes enhances communication and understanding about the significance of novel organisms and deeper understanding of known pathogens. This review addresses the addition of multiple gastrointestinal bacteria that form the normal microbiota in a variety of animals including honeybees as well as novel bacteria from domestic animals including an alpha-hemolytic Streptococcus species from guinea pigs, two Moraxella spp. from cows and goats, a new Capnocytophaga species from cats, a thermophilic Campylobacter …

Recovery Resiliency Of Interdependent Power Systems Infrastructure Subject To Extreme Events, Partha P. Sarker

Graduate Theses and Dissertations (2019 - present)

When Hurricane Maria struck the island of Puerto Rico on September 20, 2017, it devastated the island’s aging power systems infrastructure and inflicted an island-wide power outage that left Puerto Rico in total darkness for an entire week before the system slowly started to recover. This unprecedented failure of the critical power systems infrastructure exacerbated the failure of other critical infrastructures or lifeline systems of the island. This research explores and quantifies the relationships or interdependencies that exist between the power systems and other critical infrastructure systems by investigating the post-hurricane recovery data of these lifeline systems. Subsequently, the research …

Designing A Blockchain Technology Platform For Enhancing The Pre-Exposure Prophylaxis Care Continuum, Anjum Khurshid, Daniel Toshio Harrell, Dennis Li, Camden Hallmark, Ladd Hanson, Nishi Viswanathan, Michelle Carr, Armand Brown, Marlene Mcneese, Kayo Fujimoto

Faculty, Staff and Student Publications

OBJECTIVES: Pre-exposure prophylaxis (PrEP) is a key biomedical intervention for ending the HIV epidemic in the United States, but its uptake is impeded by systemic barriers, including fragmented workflows and ineffective data coordination. This study aims to design PrEPLinker, a blockchain-based, client-centered platform to enhance care to address these challenges by improving care coordination and enabling clients to securely manage their identity and PrEP-related data.

MATERIALS AND METHODS: Using Houston, Texas, as a use case, we conducted a needs assessment with PrEP collaborators to evaluate existing workflows and identify barriers in the PrEP care continuum. Based on these findings, we …

Civil Litigation | Notes, Arthur S. Leonard

Other Publications

No abstract provided.

D-Optimal Joint Best Linear Unbiased Predictors In Progressively Type-Ii Ordered Statistics, Tamim Alam

Open Access Theses & Dissertations

Reliability and life-testing experiments play a crucial role in understanding the longevity and performance of systems and components, particularly in high-stakes applications such as engineering, manufacturing, and quality control. In this thesis, we focus on the prediction of future unobserved failure times by employing joint predictors based on progressively Type-II censored data obtained from such life-testing experiments. Specifically, we derive explicit analytical expressions for the joint best linear unbiased predictors (BLUPs) of two future order statistics under the D-optimality criterion. The derivation involves minimizing the determinant of the variance-covariance matrix of the predictors within the context of progressively Type-II censored …

Geotechnical Aspects Of Extraterrestrial Regolith Simulants, Jesus Baca

Open Access Theses & Dissertations

Geotechnical engineering has been crucial to the success of construction projects on Earth, and now it is time to extend this expertise to other celestial bodies. As NASA planned the Apollo missions, geotechnical engineers conducted extensive studies to understand the properties of lunar soil, using analogs like volcanic ash and other terrestrial materials to simulate the moon's surface. Nevertheless, it was not until the inception of the year 1968 that the Surveyor landers were able to give the first actual estimates of the moon soil geotechnical characteristics such as bearing capacity, void ratio, etc. With the development of more refined …

Enhancement Of Zika Virus Infection By West Nile And Dengue Virus Antibody Positive Cord-Blood Samples From Mothers In El Paso-Texas, Jeanette Orbegozo

Open Access Theses & Dissertations

The recent Zika virus (ZIKV) outbreak and its association with microcephaly cases and other neurological syndromes are important public health concerns. A phenomenon known as antibody-dependent enhancement (ADE) involves preexisting flavivirus antibodies to a specific flavivirus that enhances the severity of a second infection with a different flavivirus. Since ZIKV is related to flaviviruses like West Nile virus (WNV) and dengue virus (DENV), prior exposure to these viruses could elicit cross-reactive antibodies that may enhance a subsequent ZIKV infection. Therefore, this study aimed to determine if WNV and DENV antibodies from cord blood enhanced ZIKV infection in vitro. Initially, a …

Functional Analysis Of The Zebrafish Orthologs Of Host Cell Factor 1 Gene, David Paz

Open Access Theses & Dissertations

Host Cell Factor C1 (HCFC1) is a transcriptional co-activator factor that regulates the expression of over 5000 different downstream target genes in human cells. Missense mutations in the HCFC1 gene cause methylmalonic acidemia homocysteinemia cblX type (cblX). cblX, a multiple congenital anomaly syndrome (MCA) characterized by abnormal brain development, craniofacial abnormalities, metabolic deficits, and intractable epilepsy. Published studies suggest that HCFC1 regulates neural precursor proliferation, number, and differentiation. However, these results were derived from studies that were performed with nonsense alleles or transient knockdown approaches. Although these results demonstrate the importance of HCFC1 in brain development, they do not replicate …

Thermal Inequity Along The Us-Mexico Border: An Analysis Of El Paso, Texas, Mia Alexandra Trevino

Open Access Theses & Dissertations

The Urban Heat Island effect (UHI) combined with rising average global temperatures invariably results in thermal inequality, the unequal distribution of temperature patterns by different socioeconomic and sociodemographic groups, resulting in an array of negative public health impacts. This thesis research focused on the historical factors that contribute to UHI and tree cover in historically underserved neighborhoods in El Paso, Texas. The impact of maps from 1933-1954 created by the Home Ownerâ??s Loan Corporation (HOLC), a federal selective lending program, resulted in decades of disinvestment and inequality especially in redlined areas. Geospatial analyses of environmental and socioeconomic indicators such as …

Water Fluoridation: The Evidence Behind The Risk Of Fluoride Use, Margherita Fontana D.D.S., Ph.D., Carlos González-Cabezas D.D.S., M.S.D., Ph.D., Livia Tenuta D.D.S., M.Sc., Ph.D.

The Journal of the Michigan Dental Association

The debate surrounding fluoride use for caries control has intensified due to recent events, including a National Toxicology Program (NTP) report and a court ruling mandating EPA action on fluoride levels in tap water.

Despite concerns about fluoride's potential neurodevelopmental impact at high concentrations, current evidence shows no adverse effects at the recommended levels of 0.7 ppm in U.S. community water fluoridation programs. While studies in regions with endemic fluorosis suggest an association between high fluoride exposure and lower IQ, methodological limitations undermine causal conclusions.

Global and U.S. health authorities, including the WHO and ADA, reaffirm the safety and efficacy …