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2024

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Role Of Apolipoprotein B In The Clinical Management Of Cardiovascular Risk In Adults: An Expert Clinical Consensus From The National Lipid Association, Daniel E Soffer, Nicholas A Marston, Kevin C Maki, Terry A Jacobson, Vera A Bittner, Jessica M Peña, George Thanassoulis, Seth S Martin, Carol F Kirkpatrick, Salim S Virani, Dave L Dixon, Christie M Ballantyne, Alan T Remaley Jan 2024

Role Of Apolipoprotein B In The Clinical Management Of Cardiovascular Risk In Adults: An Expert Clinical Consensus From The National Lipid Association, Daniel E Soffer, Nicholas A Marston, Kevin C Maki, Terry A Jacobson, Vera A Bittner, Jessica M Peña, George Thanassoulis, Seth S Martin, Carol F Kirkpatrick, Salim S Virani, Dave L Dixon, Christie M Ballantyne, Alan T Remaley

Faculty, Staff and Students Publications

This National Lipid Association (NLA) Expert Clinical Consensus provides an overview of the physiologic and clinical considerations regarding the role of apolipoprotein B (apoB) measurement to guide clinical care based on the available scientific evidence and expert opinion. ApoB represents the total concentration of atherogenic lipoprotein particles in the circulation and more accurately reflects the atherogenic burden of lipoproteins when compared to low-density lipoprotein cholesterol (LDL-C). ApoB is a validated clinical measurement that augments the information found in a standard lipoprotein lipid panel; therefore, there is clinical value in using apoB in conjunction with a standard lipoprotein lipid profile when …


Email Invitation And Survey For Faculty Whose Experience Has Mostly Been With Actual Vertical Transfer Students, Alexandra W. Logue, Vita Rabinowitz, Yoshiko Oka, Nayeon Yoo, Rhina Torres, Kerstin Gentsch, David Wutchiett Jan 2024

Email Invitation And Survey For Faculty Whose Experience Has Mostly Been With Actual Vertical Transfer Students, Alexandra W. Logue, Vita Rabinowitz, Yoshiko Oka, Nayeon Yoo, Rhina Torres, Kerstin Gentsch, David Wutchiett

Publications and Research

Copy of survey used for faculty whose experience has mostly been with actual vertical transfer (bachelor's-degree) students, along with email sent to faculty inviting them to complete the survey.


Editorial: Symmetry As A Guiding Principle In Artificial And Brain Neural Networks, Volume Ii, Fabio Anselmi, Ankit B Patel Jan 2024

Editorial: Symmetry As A Guiding Principle In Artificial And Brain Neural Networks, Volume Ii, Fabio Anselmi, Ankit B Patel

Faculty, Staff and Students Publications

No abstract provided.


Accretion Of Warm Chondrules In Weakly Metamorphosed Ordinary Chondrites And Their Subsequent Reprocessing, Alexander M. Ruzicka, Richard C. Hugo, Jon M. Friedrich, Michael Tyler Ream Jan 2024

Accretion Of Warm Chondrules In Weakly Metamorphosed Ordinary Chondrites And Their Subsequent Reprocessing, Alexander M. Ruzicka, Richard C. Hugo, Jon M. Friedrich, Michael Tyler Ream

Geology Faculty Datasets

To better understand chondrite accretion and subsequent processes, the textures, crystallography, deformation, and compositions of some chondrite constituents in ten lithologies of different cluster texture strength were studied in seven weakly metamorphosed (Type 3) and variably shocked ordinary chondrites (Ragland—LL3 S1, Tieschitz—H/L3 S1, NWA 5421—LL3 S2, NWA 5205—LL3 S2, NWA 11905—LL3-5 S3, NWA 5781—LL3 S3, NWA 11351—LL3-6 S4) using optical and electron microscopy and microtomography techniques. Results support a four-stage model for chondrite formation. This includes 1) limited annealing following collisions during chondrule crystallization and rapid cooling in space prior to accretion, as evidenced by olivine microstructures consistent with dislocation …


Legacy Of Labour: The Impact Of Parental Occupations On Children’S Careers Choices And Income Inequality, Swapnil Landge Jan 2024

Legacy Of Labour: The Impact Of Parental Occupations On Children’S Careers Choices And Income Inequality, Swapnil Landge

Publications and Research

This paper investigates how intergenerational occupational mobility and self-selection into occupations are influenced by the occupations of parents. The results demonstrate that children who pursue their parents’ occupations, particularly those in the lowest earnings percentiles, are more negatively self-selected compared to those whose parents are in the highest earning deciles. In particular, 65% of the children who pursue their parents’ occupation in Decile 1, 49% in Decile 2, 32% in Decile 3 and 26% in Decile 4 would have achieved higher productivity and earned higher earnings in high-income occupations (specifically in Decile 10 occupations). In contrast, children from high-income backgrounds …


Parents, Paths, And Paychecks: Examining Intergenerational Occupational Mobility And Career Choices, Swapnil Landge Jan 2024

Parents, Paths, And Paychecks: Examining Intergenerational Occupational Mobility And Career Choices, Swapnil Landge

Publications and Research

This paper examines the influence of fathers’ and mothers’ occupations on their children’s occupational outcomes, using a self-selection model to analyze intergenerational career mobility. By constructing and analyzing transition matrices, I estimate the extent of positive and negative self-selection for sons and daughters when they follow either their father’s or mother’s occupation. The results reveal distinct patterns for sons and daughters. Sons who follow their father’s occupation tend to avoid negative self-selection, particularly in higher-paying fields such as Professional Occupations and Technicians and Related Support Occupations, where negative self-selection is minimal. Conversely, sons following their mother’s occupation face higher rates …


Structural And Magnetic Properties Of Molecular Beam Epitaxy (Mnsb2te4)X(Sb2te3)1−X Topological Materials With Exceedingly High Curie Temperature, Candice R. Forrester, Christophe Testelin, Kaushini Wickramasinghe, Ido Levy, Dominique Demaille, David Hrabovsky, Xiaxin Ding, Lisa Krusin-Elbaum, Gustavo Lopez, Maria C. Tamargo Jan 2024

Structural And Magnetic Properties Of Molecular Beam Epitaxy (Mnsb2te4)X(Sb2te3)1−X Topological Materials With Exceedingly High Curie Temperature, Candice R. Forrester, Christophe Testelin, Kaushini Wickramasinghe, Ido Levy, Dominique Demaille, David Hrabovsky, Xiaxin Ding, Lisa Krusin-Elbaum, Gustavo Lopez, Maria C. Tamargo

Publications and Research

Tuning the properties of magnetic topological materials is of interest to realize exotic physical phenomena, new quantum phases and quasiparticles, and topological spintronic devices. However, current topological materials exhibit Curie temperature (TC) values far below those needed for practical applications. In recent years, significant progress has been made to control and optimize TC, particularly through defect-engineering of these structures. Most recently, we reported TC values up to 80 K for (MnSb2Te4)x(Sb2Te3)1−x when 0.7 ≤ x ≤ 0.85 by controlling the composition x and the …


Photo-Induced Charge State Dynamics Of The Neutral And Negatively Charged Silicon Vacancy Centers In Room-Temperature Diamond, G. Garcia-Arellano, G. I. López-Morales, N. B. Manson, J. Flick, A. A. Wood, C. A. Meriles Jan 2024

Photo-Induced Charge State Dynamics Of The Neutral And Negatively Charged Silicon Vacancy Centers In Room-Temperature Diamond, G. Garcia-Arellano, G. I. López-Morales, N. B. Manson, J. Flick, A. A. Wood, C. A. Meriles

Publications and Research

The silicon vacancy (SiV) center in diamond is drawing much attention due to its optical and spin properties, attractive for quantum information processing and sensing. Comparatively little is known, however, about the dynamics governing SiV charge state interconversion mainly due to challenges associated with generating, stabilizing, and characterizing all possible charge states, particularly at room temperature. Here, multi-color confocal microscopy and density functional theory are used to examine photo-induced SiV recombination — from neutral, to single-, to double-negatively charged — over a broad spectral window in chemical-vapor-deposition (CVD) diamond under ambient conditions. For the SiV0 to SiV‒ transition, …


Radiation Pressure Induced Oscillations Of An Optically Levitating Mirror, Satyam Shekhar Jha, Tal Carmon, Fan Cheng, Lev Deych Jan 2024

Radiation Pressure Induced Oscillations Of An Optically Levitating Mirror, Satyam Shekhar Jha, Tal Carmon, Fan Cheng, Lev Deych

Publications and Research

Optical Fabry–Perot cavity with a movable mirror is a paradigmatic optomechanical system. While usually the mirror is supported by a mechanical spring, it has been shown that it is possible to keep one of the mirrors in a stable equilibrium purely by optical levitation without any mechanical support. In this work, we expand previous studies of the nonlinear dynamics of such a system by demonstrating a possibility for mechanical parametric instability and the emergence of the “phonon laser” phenomenon.


On Cyclically 4-Connected Cubic Graphs, R. J. Kingan, S. R. Kingan Jan 2024

On Cyclically 4-Connected Cubic Graphs, R. J. Kingan, S. R. Kingan

Publications and Research

A 3-connected cubic graph is cyclically 4-connected if it has at least n ≥ 8 vertices and when removal of a set of three edges results in a disconnected graph, only one component has cycles. By introducing the notion of cycle spread to quantify the distance between pairs of edges, we get a new characterization of cyclically 4-connected graphs. Let Qn and Vn denote the ladder and Möbius ladder on n ≥ 8 vertices, respectively. We prove that a 3-connected cubic graph G is cyclically 4-connected if and only if G is either the Petersen graph, Q …


It Is Normal: The Probability Distribution Of Temperature Extremes, Nir Y. Krakauer Jan 2024

It Is Normal: The Probability Distribution Of Temperature Extremes, Nir Y. Krakauer

Publications and Research

The probability of heat extremes is often estimated using the non-stationary generalized extreme value distribution (GEVD) applied to time series of annual maximum temperature. Here, this practice was assessed using a global sample of temperature time series, from reanalysis (both at the grid point and the region scale) as well as station observations. This assessment used forecast negative log-likelihood as the main performance measure, which is particularly sensitive to the most extreme heat waves. It was found that the computationally simpler normal distribution outperforms the GEVD in providing probabilistic year-ahead forecasts of temperature extremes. Given these findings, it is suggested …


Quotients Of The Curve Complex, Joseph Maher, Hidetoshi Masai, Saul Schleimer Jan 2024

Quotients Of The Curve Complex, Joseph Maher, Hidetoshi Masai, Saul Schleimer

Publications and Research

We consider three kinds of quotients of the curve complex, which are obtained by coning off uniformly quasiconvex subspaces: symmetric curve sets, non-maximal train track sets, and compression body disc sets. We show that the actions of the mapping class group on those quotients are strongly weakly properly discontinuously (WPD), which implies that the actions are non-elementary and those quotients are of infinite diameter.


Time-Efficient Filtering Of Imaging Polarimetric Data By Checking Physical Realizability Of Experimental Mueller Matrices, Tatiana Novikova, Alexey Ovchinnikov, Gleb Pogudin, Jessica C. Ramella-Roman Jan 2024

Time-Efficient Filtering Of Imaging Polarimetric Data By Checking Physical Realizability Of Experimental Mueller Matrices, Tatiana Novikova, Alexey Ovchinnikov, Gleb Pogudin, Jessica C. Ramella-Roman

Publications and Research

Motivation: Imaging Mueller polarimetry has already proved its potential for biomedicine, remote sensing, and metrology. The real-time applications of this modality require both video rate image acquisition and fast data post-processing algorithms. First, one must check the physical realizability of the experimental Mueller matrices in order to filter out non-physical data, i.e. to test the positive semi-definiteness of the 4 × 4 Hermitian coherency matrix calculated from the elements of corresponding Mueller matrix pixel-wise. For this purpose, we compared the execution time for the calculations of (i) eigenvalues, (ii) Cholesky decomposition, (iii) Sylvester’s criterion, and (iv) coefficients of the characteristic …


Reflections On Williamson On Logic And Validity, Graham Priest Jan 2024

Reflections On Williamson On Logic And Validity, Graham Priest

Publications and Research

Over many years now, Tim Williamson and I have engaged in debates over fundamental issues concerning logic. On some things, we have disagreed strongly; on others, we have agreed.


A Definition Of A Heywood Case In Item Response Theory Based On Fisher Information, Jay Verkuilen, Peter J. Johnson Jan 2024

A Definition Of A Heywood Case In Item Response Theory Based On Fisher Information, Jay Verkuilen, Peter J. Johnson

Publications and Research

Heywood cases and other improper solutions occur frequently in latent variable models, e.g., factor analysis, item response theory, latent class analysis, multilevel models, or structural equation models, all of which are models with response variables taken from an exponential family. They have important consequences for scoring with the latent variable model and are indicative of issues in a model, such as poor identification or model misspecification. In the context of the 2PL and 3PL models in IRT, they are more frequently known as Guttman items and are identified by having a discrimination parameter that is deemed excessively large. Other IRT …


It’S About Time, Part Ii: Does Time Poverty Contribute To Inequitable College Outcomes By Gender And Race/Ethnicity?, Claire Wladis, Alyse C. Hachey, Katherine M. Conway Jan 2024

It’S About Time, Part Ii: Does Time Poverty Contribute To Inequitable College Outcomes By Gender And Race/Ethnicity?, Claire Wladis, Alyse C. Hachey, Katherine M. Conway

Publications and Research

Existing research demonstrates gender- and race/ethnicity-based inequities in college outcomes. Separately, recent research suggests a relationship between time poverty and college outcomes for student parents and online students. However, to date, no studies have empirically explored whether differential access to time as a resource for college may explain differential outcomes by gender or race/ethnicity. To address this, this study explored the relationship between time poverty, gender or race/ethnicity, and college outcomes at a large urban public university with two and four year campuses. Time poverty explained a significant proportion of differential outcomes (retention and credit accumulation) by gender and race/ethnicity. …


Effective Size Of A Parity-Time-Symmetric Dimer, Li Ge Jan 2024

Effective Size Of A Parity-Time-Symmetric Dimer, Li Ge

Publications and Research

Parity-time (PT)-symmetric dimers were introduced to highlight the unusual properties of non-Hermitian systems that are invariant after a combined parity and time reversal operation. They are also the building blocks of a variety of symmetry and topologically protected structures, especially on integrated photonic platforms. As the name suggests, it consists of two coupled oscillators, which can be optical, mechanical, electronic, and so on in nature. In this article, we show that its effective size, defined by the number of lattice sites inversely proportional to the lattice momentum, is surprisingly three instead of two from the perspective of energy quantization. More …


Raps Sheet, January 2024, Retirement Association Of Portland State Jan 2024

Raps Sheet, January 2024, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.


Common Raven Resource Selection, Diet, And Behavior Around A Threatened Shorebird, Janelle Chojnacki Jan 2024

Common Raven Resource Selection, Diet, And Behavior Around A Threatened Shorebird, Janelle Chojnacki

Cal Poly Humboldt theses and projects

Human food subsidies have allowed populations of the common raven (Corvus corax) to expand and increase in density, especially in the western United States, which has amplified predation risk for other native species. Common ravens are well-documented nest predators of the federally threatened Western snowy plover (Anarhynchus nivosus nivosus) in Humboldt County, California; however, little is known about raven movement and foraging behavior in and around snowy plover habitat. Using GPS tracking and behavioral surveys, I examined movement and foraging behavior of beach-going ravens across snowy plover nesting habitat and I explored raven diet through stable isotope …


Recovery Of Riparian Shade And Stream Temperature After Thinning In Coastal Redwood Riparian Forests, Preston J. Selby Jan 2024

Recovery Of Riparian Shade And Stream Temperature After Thinning In Coastal Redwood Riparian Forests, Preston J. Selby

Cal Poly Humboldt theses and projects

Historical forest harvest methods such as clear-cut harvesting in the Pacific Northwest have led to dense, even-aged stands, particularly in riparian forests. In an effort to promote the recovery of late-successional conditions, land managers have turned to silvicultural approaches such as thinning, though few studies have evaluated its long-term effects in riparian areas. Due to stream-riparian linkages, changes in riparian forests can directly influence stream ecosystems, particularly thermal regimes, by altering shade and solar radiation influx. Thus, understanding the temporal and spatial impacts of riparian thinning is crucial for land managers interested in thinning as a potential restoration tool for …


Barn Owls Exert Top-Down Effects On The Abundance And Behavior Of Rodent Pests, Katherine C. Larson Jan 2024

Barn Owls Exert Top-Down Effects On The Abundance And Behavior Of Rodent Pests, Katherine C. Larson

Cal Poly Humboldt theses and projects

Predators can exert top-down effects on their prey by direct consumption, by imposing risk of predation, or a combination of both. However, empirical evidence for these effects is mixed and inconsistent. Barn owls in agriculture present a system with attributes that should, according to theory, lead to strong top-down effects, but research is limited and the distinction between effects on prey abundance and behavior remains unresolved. Understanding the top-down effect of predators on pests is a cornerstone of integrated pest management and important where barn owls may contribute to the control of rodents on farms. Vegetation can mediate the top-down …


Drought's Lingering Shadow: Monitoring The Recovery Of Sagebrush Steppe Plant Communities After Four Years Of Experimental Drought, Francisco Jesus Chavez Jan 2024

Drought's Lingering Shadow: Monitoring The Recovery Of Sagebrush Steppe Plant Communities After Four Years Of Experimental Drought, Francisco Jesus Chavez

Cal Poly Humboldt theses and projects

Droughts are projected to increase in frequency and intensity due to climate change, which will significantly impact terrestrial ecosystems. However, the response magnitude will vary depending on a system's resistance and resilience to drought. Furthermore, drought may elicit different responses within the hierarchical levels of plant communities (i.e., individual, community, or ecosystem responses). These effects can extend beyond the drought's duration as legacies persist and influence previously disturbed systems. I assessed whether hierarchical responses occurred within two different adjacent sagebrush plant communities, dominated by Artemisia arbuscula and Artemisia cana, during and after an experimental drought. I used nondestructive point frame …


Fire Severity Mediates Marten And Fisher Occurrence: Impacts Of The Dixie Fire On A Carnivore Community, Christopher James Collier Jan 2024

Fire Severity Mediates Marten And Fisher Occurrence: Impacts Of The Dixie Fire On A Carnivore Community, Christopher James Collier

Cal Poly Humboldt theses and projects

The consumption of an astounding one million acres resulted from California’s largest single fire to date, the 2021 Dixie Fire. The social and economic losses associated with the fire were immediately apparent, but the effects on wildlife remained unknown. While previous research has suggested mixed or low severity fire may be beneficial to certain wildlife species, the responses to megafires are poorly understood for many carnivores. To better understand these responses to severe fire, I used a random sampling design stratified by burn severity to survey in and around the Dixie Fire footprint using baited camera stations. This allowed me …


The Use Of Fluorescence Lifetime Imaging (Flim) For In Situ Microbial Detection In Complex Mineral Substrates, Yekaterina G. Chmykh, Jay Nadeau Jan 2024

The Use Of Fluorescence Lifetime Imaging (Flim) For In Situ Microbial Detection In Complex Mineral Substrates, Yekaterina G. Chmykh, Jay Nadeau

Physics Faculty Publications and Presentations

The utility of fluorescence lifetime imaging microscopy (FLIM) for identifying bacteria in complex mineral matrices was investigated. Baseline signals from unlabelled Bacillus subtilis and Euglena gracilis, and Bacillus subtilis labelled with SYTO 9 were obtained using two-photon excitation at 730, 750 and 800 nm, identifying characteristic lifetimes of photosynthetic pigments, unpigmented cellular autofluorescence, and SYTO 9. Labelled and unlabelled B. subtilis were seeded onto marble and gypsum samples containing endolithic photosynthetic cyanobacteria and the ability to distinguish cells from mineral autofluorescence and nonspecific dye staining was examined in parallel with ordinary multichannel confocal imaging. It was found that FLIM …


Assessment Of Avian Community Structure And Habitat Connectivity In The Fanno Creek Corridor Bird Surveys, Habitat Assessment, And Management Recommendations, Grace Hall Jan 2024

Assessment Of Avian Community Structure And Habitat Connectivity In The Fanno Creek Corridor Bird Surveys, Habitat Assessment, And Management Recommendations, Grace Hall

Environmental Science and Management Professional Master's Project Reports

Urbanization can significantly impact habitat quality and connectivity for avian communities, decreasing species richness and diversity. However, in highly fragmented habitats, urban parks and riparian zones can provide important habitat corridors for birds that facilitate movement and access to essential resources. On the west side of greater Portland, Oregon, Fanno Creek may serve as a habitat corridor for birds and other local wildlife.

Fanno Creek is a 25-kilometer tributary of the Tualatin River that runs through the cities of Portland, Beaverton, Tigard, and Durham in northwestern Oregon. The land surrounding the creek includes residential, commercial, and industrial properties as well …


Moisture-Controlled Triboelectrification During Coffee Grinding, Joshua Méndez Harper, Yong-Hyun Kim, Robin E. Bumbaugh, Connor S. Mcdonald, Christopher H. Hendon, Elana J. Cope, Leif E. Lindberg, Justin Pham, Multiple Additional Authors Jan 2024

Moisture-Controlled Triboelectrification During Coffee Grinding, Joshua Méndez Harper, Yong-Hyun Kim, Robin E. Bumbaugh, Connor S. Mcdonald, Christopher H. Hendon, Elana J. Cope, Leif E. Lindberg, Justin Pham, Multiple Additional Authors

Electrical and Computer Engineering Faculty Publications and Presentations

Triboelectrification is the physical process where materials acquire surface charge from frictional interactions at their interfaces.The magnitude of charge depends on the interfacial material composition and can be harnessed in emergent technologies for energy generation.

The mechanism of electrostatic accumulation is complex and is further obscured in granular materials where collisions are sufficiently energetic to cause fracturing. In this “fractoelectric” regime, crack initiation and propagation are thought to charge particles through transfer of electrons and/or ions at the hot crack interface.

Whether a material’s charging is dominated by tribo- or fractoelectrification, fracture-generated granular flows often comprise particles whose surface charge …


Analyzing Frequency Event Detection Algorithm Performance Using Different Denoising Methods, Hussain A. Alghamdi, Midrar Adham, Robert Bass Jan 2024

Analyzing Frequency Event Detection Algorithm Performance Using Different Denoising Methods, Hussain A. Alghamdi, Midrar Adham, Robert Bass

Electrical and Computer Engineering Faculty Publications and Presentations

Maintaining grid frequency at its nominal value is crucial for power system stability and supply-demand balance. Swift and accurate detection of frequency events is vital for providing primary frequency response support. Frequency event detection algorithms often rely on Phasor Measurement Unit data, which may contain noise. Implementing a denoising preprocessing step enhances detection precision and accuracy. In previous works, a frequency event detection algorithm based on wavelet transform was developed, which uses discrete wavelet transform (DWT) for denoising purposes. In this paper, several denoising techniques are considered as potential replacements for the current DWT method. This research investigates and compares …


A Comprehensive Meta-Analysis Of Tissue Resident Memory T Cells And Their Roles In Shaping Immune Microenvironment And Patient Prognosis In Non-Small Cell Lung Cancer, Aidan Shen, Aliesha Garrett, Cheng-Chi Chao, Dongliang Liu, Chao Cheng, Zhaohui Wang, Chen Qian, Yangzhi Zhu, Junhua Mai, Chongming Jiang Jan 2024

A Comprehensive Meta-Analysis Of Tissue Resident Memory T Cells And Their Roles In Shaping Immune Microenvironment And Patient Prognosis In Non-Small Cell Lung Cancer, Aidan Shen, Aliesha Garrett, Cheng-Chi Chao, Dongliang Liu, Chao Cheng, Zhaohui Wang, Chen Qian, Yangzhi Zhu, Junhua Mai, Chongming Jiang

Faculty, Staff and Students Publications

Tissue-resident memory T cells (TRM) are a specialized subset of long-lived memory T cells that reside in peripheral tissues. However, the impact of TRM-related immunosurveillance on the tumor-immune microenvironment (TIME) and tumor progression across various non-small-cell lung cancer (NSCLC) patient populations is yet to be elucidated. Our comprehensive analysis of multiple independent single-cell and bulk RNA-seq datasets of patient NSCLC samples generated reliable, unique TRM signatures, through which we inferred the abundance of TRM in NSCLC. We discovered that TRM abundance is consistently positively correlated with CD4+ T helper 1 cells, M1 macrophages, and resting dendritic cells in the TIME. …


Siglec15, Negatively Correlated With Pd-L1 In Hcc, Could Induce Cd8+ T Cell Apoptosis To Promote Immune Evasion, Zheng Chen, Mincheng Yu, Bo Zhang, Lei Jin, Qiang Yu, Shuang Liu, Binghai Zhou, Jiuliang Yan, Wentao Zhang, Xiaoqiang Li, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Hui Li, Lei Guo Jan 2024

Siglec15, Negatively Correlated With Pd-L1 In Hcc, Could Induce Cd8+ T Cell Apoptosis To Promote Immune Evasion, Zheng Chen, Mincheng Yu, Bo Zhang, Lei Jin, Qiang Yu, Shuang Liu, Binghai Zhou, Jiuliang Yan, Wentao Zhang, Xiaoqiang Li, Yongfeng Xu, Yongsheng Xiao, Jian Zhou, Jia Fan, Mien-Chie Hung, Qinghai Ye, Hui Li, Lei Guo

Faculty, Staff and Student Publications

Functional roles of SIGLEC15 in hepatocellular carcinoma (HCC) were not clear, which was recently found to be an immune inhibitor with similar structure of inhibitory B7 family members. SIGLEC15 expression in HCC was explored in public databases and further examined by PCR analysis. SIGLEC15 and PD-L1 expression patterns were examined in HCC samples through immunohistochemistry. SIGLEC15 expression was knocked-down or over-expressed in HCC cell lines, and CCK8 tests were used to examine cell proliferative ability in vitro. Influences of SIGLEC15 expression on tumor growth were examined in immune deficient and immunocompetent mice respectively. Co-culture system of HCC cell lines and …


Diagnostic Value Of Soluble Urokinase-Type Plasminogen Activator Receptor In Patients With Acute Coronary Syndrome: A Systematic Review And Meta-Analysis, Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak Jan 2024

Diagnostic Value Of Soluble Urokinase-Type Plasminogen Activator Receptor In Patients With Acute Coronary Syndrome: A Systematic Review And Meta-Analysis, Michal Pruc, Iwona Jannasz, Damian Swieczkowski, Grzegorz Procyk, Aleksandra Gasecka, Zubaid Rafique, Francesco Chirico, Nicola Luigi Bragazzi, Milosz J Jaguszewski, Jaroslaw Wysocki, Lukasz Szarpak

Faculty, Staff and Students Publications

BACKGROUND: In contemporary clinical practice, there is an increasing need for new clinically relevant biomarkers potentially optimizing management strategies in patients with suspected acute coronary syndrome (ACS). This study aimed to determine the diagnostic utility of soluble urokinase-type plasminogen activator receptor (suPAR) levels in individuals with suspected ACS.

METHODS: A literature search was performed in Web of Science, PubMed, Scopus, and the Cochrane Central Register of Controlled Trials databases, for studies comparing suPAR levels among patients with and without ACS groups. The methodological quality of the included papers was assessed using the Newcastle-Ottawa Scale (NOS). A fixed-effects model was used …