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Efficient Synthesis Of Thiazole-Fused Bisnoralcohol Derivatives As Potential Therapeutic Agents, Subrata Roy, Hansa Raj Kc, Sanjay Adhikary, Alexander N. Erickson, Mohammad Abrar Alam

Chemistry Faculty Research and Publications

Thiazole derivatives are known for a wide range of therapeutic properties. Bisnoralcohol is an inexpensive natural product obtained by the biodegradation of sterols. This article describes an efficient synthesis of a library of thiazole-fused bisnoralcohol derivatives. These novel compounds have been studied for their antineoplastic and antibacterial properties, which led to the discovery of hit compounds with therapeutic potential. The antibacterial compound is noncytotoxic and nonhemolytic against cancer cell lines and sheep red blood cells, respectively. Several of the antineoplastic compounds showed activity against human cancer cell lines with growth inhibition at submicromolar concentration.

Nsu Florida Undergraduate Student Catalog 2024-2025, Nova Southeastern University

Undergraduate Programs Course Catalogs

No abstract provided.

Optimizing Field-Linked Simulations Of Dry Season Uptake And Monsoon Infiltration Within An Aspen-Mixed Conifer Forest, Raymond J. Hess

Master's Theses

Climate models forecast that headwater catchments in the western U.S. will undergo a reduction in snowpack, early season snowmelt, and increases in evapotranspiration. The resulting extended dry season will stress vegetation in mountainous watersheds throughout the Upper Colorado River Basin. We investigate infiltration patterns and root water uptake in response to dry season disturbances within the East River watershed in Colorado. To do this, we collected soil cores, measured matric potential and sap flow, and monitored tree xylem and soil for stable isotopes of water (2H, 18O) in two soil profiles to 90 cm depth (with three Engelmann spruce and …

The Impact Of Low-Skew On The Ultimate Capacity Of Press-Brake-Formed Tub Girders, Madison Lynn Morgan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The development of press-brake-formed tub girders (PBFTGs) has offered innovative solutions for short-span steel bridge applications and helps meet the demand for rapid infrastructure replacement solutions. The Short Span Steel Bridge Alliance (SSSBA) comprises bridge and buried soil structure industry leaders who aim to provide essential educational information to bridge and highway professionals on the design and construction of short-span steel bridge installations (SSSBA, 2020). The American Association of State and Highway Transportation Officials (AASHTO) provides design standards, specifications, and guidance for the analysis and construction of PBFTGs. Currently, the AASHTO Load Resistance and Factor Design Bridge Design Specifications (AASHTO …

Stakeholder Participation And Perceptions In Professional Learning Communities: A Case Study In A Small, Rural School District, Rachel M. Kowalski

Theses and Dissertations

This applied dissertation explored the interplay between collaboration within PLCs and classroom teacher perceptions of PLC implementation within a small, rural district. It examined how the involvement of different stakeholders in PLCs connects to overall perceptions of professional learning communities and how the participation of principals, administrators, and paraprofessionals shapes collaboration. The unique setting of a small and rural school district allowed the study to consider close interpersonal relationships that are common within these settings since these districts have limited human resources and individuals serve in various capacities within the organization. When stakeholders actively participate in PLCs, concerns arise about …

Computational And Experimental Modeling Of Particle Transport Inside Respiratory Pathways And Indoor Environments, Abir Malakar

Electronic Theses and Dissertations

This thesis aims to explore efficient drug delivery to clinical target sites along the human upper airway that strongly depends on variables associated with the delivery device and the drug formulation, e.g., the device plume angle, particle sizes of drug solution, drug delivery speed of the device, viscosity of the drug solution, delivery axis orientation, and the formulation density. In our investigation, we prioritize the nasopharynx, the primary site of initial viral infection, as the ideal target zone for drug delivery. We have used Large Eddy Simulation and Lagrangian techniques to replicate breathing at 15 L/min and quantify regional drug …

Portable X-Ray Fluorescence Spectrometry For Sensing Salinity And Sodicity In Glacial Northern Great Plains Soils With Machine Learning Models, Adam Devlin

Electronic Theses and Dissertations

Saline and sodic soils are an increasing concern across the Northern Great Plains (NGP) due to factors of climate change and land management that are drawing geologically derived salts to the land surface. Traditional laboratory assessments, such as electrical conductivity (EC) and sodium adsorption ratio (SAR), are time and resource consumptive. Portable X-ray fluorescence (PXRF) may be a viable proximal sensing alternative, as it is able to provide elemental data in minutes, in situ or ex situ, and can directly quantify salinity-associated elements like Ca, Mg, and S. PXRF paired with predictive models has proven useful for a range of …

Longevity In Afrikaner Cattle: A Survival Analysis, Allison M. Bot Steffl

Electronic Theses and Dissertations

The Afrikaner breed of cattle is indigenous to South Africa and due to their hardiness was once the most popular breed amongst farmers. The objectives for this study were to: (1) estimate environmental effects (age at first calving, season) and (2) genetic variance affecting longevity in Afrikaner cattle using survival analysis and a Weibull model and (3) evaluate the effect of the Infusion Project on longevity utilizing a Cox model. For the first objective, age at first calving impacted longevity as younger age at first calving was associated with decreased longevity. Season of birth and year of birth also impacted …

Soil Responses To Eastern Redcedar (Juniperus Virginiana L.) Afforestation And Prescribed Fire In South-Central South Dakota, Robert Schaefer

Electronic Theses and Dissertations

Research was conducted in 2019 and 2020 on rangelands located in south-central South Dakota assessing a number of physical, chemical, and biological properties of mineral ustepts and ustents soils associated with eastern redcedar (ERC) (Juniperus virginiana) afforestation and prescribed fire. ERC afforestation appeared to be associated with significantly higher field-condition soil aggregate stability, cation exchange capacity (CEC), soil pH, and fungi:bacteria (F:B) as well as significantly lower soil moisture, nitrate-N, phosphorus, bacteria biomass, and Gram-positive:Gram-negative (GP:GN) bacteria compared to native grassland conditions, while other mineral soil properties appeared relatively unaffected. Compared to soil conditions under dense, living ERC canopies, prescribed …

Increasing Retention Of Women In Hunting And Fishing, Shelby Isensee

Electronic Theses and Dissertations

Despite national declines in hunting and fishing, women are making inroads in historically male-dominated sports. To further encourage women’s participation, states established programs to recruit, retain, and reactivate [R3] hunters and anglers. Women are participating in these programs and other recreational groups to access opportunities to learn skills and grow their networks. Yet, very little is known about what programs are offered for women, what aspects of programs are most effective to support women’s retention in these activities, and what women’s hunting and fishing groups are available across the landscape. To address these questions, I collected qualitative data from participant …

Respiratory Disease In Bighorn Sheep: A Varied Investigation Of Immunization, Transmission, And Detection, Katelin Frerichs

Electronic Theses and Dissertations

Respiratory disease has historically been recognized as a limiting factor to wild bighorn sheep (Ovis canadensis) herds throughout North America with epizootics resulting in large-scale die offs and reductions in recruitment. The primary etiologic agent associated with pneumonia outbreaks in bighorn sheep is Mycoplasma ovipneumoniae. This bacterial pathogen is frequently carried asymptomatically by domestic sheep (Ovis aries) and goats (Capra hircus); however, when these domestic hosts come in contact with and spread this pathogen to bighorns, the disease can cause epizootics and large-scale mortality. Domestic sheep strains are more commonly detected in bighorn sheep than domestic goat strains, and previous …

Perceptions Of Grade-11 Students On The School-Based Assessment In English A And B And Its Impact On Sense Of Self-Efficacy, Karlene Smith-Hines

Theses and Dissertations

This applied dissertation explored how 11th-grade students perceived the English A and B school-based assessment (SBA) and whether their portfolio experience impacted their sense of self-efficacy. Significant research has been conducted on the SBA exploring its benefits, impact, and relevance as well as the challenges and concerns encountered with implementation in various disciplines. Most of the research, however, has focused on teacher perspectives with minimal research exploring student perspectives and the assessment’s impact on them socially and academically.

This qualitative research study adopted an ethnographic approach with a realistic design to conduct this inquiry. This method was used because the …

Western Pacific K-12 Educators’ Adoption Of Digital Game-Based Learning, Lorraine Raqueño Catienza

Theses and Dissertations

Western Pacific educational institutions are investing heavily in technology in classrooms to meet the needs of K-12 students. Measuring the effective use of digital technologies in the learning environment has become a routine part of monitoring and evaluating classroom instruction. One area of technology integration that has seen tremendous growth is digital game-based learning (DGBL). The researcher is interested in examining K-12 western Pacific teachers’ willingness to adopt DGBL through a modified Technology Acceptance Model. This study aims to examine the extent to which teachers’ perceived usefulness, perceived ease of use, and technology self-efficacy effects attitude toward adopting DGBL methods. …

Challenges Teachers Face When Implementing Mult-Tiered Systems Of Supports: Recommendations And Interventions, Amber Durrett Drake

Theses and Dissertations

The purpose of this study was to examine the challenges that teachers faced when it came to the implementation of interventions and recommendations in the Mult-Tiered System of Support (MTSS). Through the MTSS, educators provided concentrated teaching, detected early signs of issues related to academic, behavioral, and speech deficiencies, and recommended fact-based interventions and practices in response to students’ needs. Identifying students’ deficits early reduced the risk of large student gaps and improved overall progress. Participants were seven Pre-k through Grade 5 teachers working in a Title 1 school located in a large metropolitan city area. Participants were selected through …

Perceptions Of Secondary School Mathematics Teachers Regarding Teaching Mathematics With Conceptual Understanding, Latisa Williams

Theses and Dissertations

This dissertation was designed to provide current knowledge on the mindset of secondary school mathematics teachers regarding the use of Conceptual Understanding (CU) as an approach to teaching the subject. It is well-documented that when students learn to engage in mathematical conceptual explanations in meaningful ways, they improve their learning. However, reports have shown that students in secondary schools lack effective skills in explaining and applying CU for successful problem-solving. As a result, teachers struggle with methods of instruction that can effectively improve the level of CU with their students in mathematics.

For this study, the researcher used a qualitative …

Assessing The Needs Of Elementary School Students From Low Socioeconomic Environments Displaying Poor Performance In Reading, Reynaldo Flores

Theses and Dissertations

This dissertation was designed to provide current information on the low reading level of students in Grade 4 who are from families of low socioeconomic status (SES). While it was known that SES is crucial to student learning which gave rise to initiates to address the problem, low SES students in elementary school continue to struggle to read at grade level. The Every Student Succeeds Act (ESSA) is used to measure performance index framework in reading along with mathematics, writing, science, and social studies to address and correct deficiencies. The data for the ESSA was drawn from the State of …

Efectividad De Una Estrategia De Gamificación En El Aprendizaje En Un Curso De Microbiología En Una Escuela Superior En Puerto Rico, Frank Gregorio Torres Vélez

Theses and Dissertations

El propósito de este estudio fue determinar la efectividad de una técnica de gamificación en la proficiencia académica de estudiantes sobre estructuras y funciones celulares de organismos procariotas en una escuela especializada en ciencias y matemáticas de Puerto Rico. Esta investigación se fundamentó en la Teoría del Aprendizaje Gamificado de Landers y Teoría de la Autodeterminación de Deci y Ryan. Una muestra de 36 estudiantes del 11mo y 12mo grado, matriculados en un curso de Microbiología, participaron de este estudio cuantitativo de muestreo no probabilístico. Los estudiantes participaron de una clase invertida, ¡una actividad gamificada mediante Kahoot!, completaron preprueba, posprueba …

A Phenomenological Study Of Online Physical Education On Former Students’ Activity Levels And Fitness Concepts Knowledge, Jerry Veshio

Theses and Dissertations

This applied dissertation was designed to provide an understanding of the perspectives of former online physical education high school students and how participation in the course affected their ability to be active post-high school and their knowledge of fitness concepts. A phenomenological design was used to guide the study’s investigation. Participants in the study were interviewed about their experiences in online physical education while in high school and how that experience currently influences their physical activity levels. Additionally, respondents described the positives and negatives of their experience in the course, specifically as it relates to the course materials, assessments, instructor …

Desert Or Mirage? An Examination Of Food Deserts In Iowa Cities, Andrew Creasey

Graduate Research Papers

Food insecurity affects millions of Americans and has been widely recognized as a significant health and economic issue. Because of this, researchers have sought to develop ways to identify areas that are prone to food insecurity, which have become known as food deserts. Food deserts have been broadly defined through a confluence of three factors: low income, a lack of vehicle access, and a predetermined distance from a healthy food retailer. But research into food deserts in Iowa is limited, and the most prominent source of information on this topic, the Food Access Research Atlas created by the U.S. Department …

Neoclassical Production, Scarcity Of Skills And Pareto Distributions, Armando R. Lopez-Velasco

School of Economics and Finance Faculty Publications

The distribution of top earnings follows a “power-law”: the top tail of the distribution is thick relative to other distributions and is approximately Pareto-distributed. There are different mechanisms proposed in the literature that yield Pareto distributions and power-laws. This paper shows that a simple general equilibrium model where aggregate production is assumed of the constant-elasticity-of-substitution (CES) type over multiple labor inputs generates distributions in earnings and wages that follow power-laws. The finding is very general as the distribution of the skill-types is irrelevant for the shape parameter (the Pareto exponent) of the power-law. The model displays a tight relationship between …

Late-Arriving Votes And Electoral Fraud: A Natural Experiment And Regression Discontinuity Evidence From Bolivia, Diego Escobari, Gary A. Hoover

School of Economics and Finance Faculty Publications

This paper uses a unique data set and a natural experiment to test if electoral fraud can exist in late-arriving votes. On the night of the 2019 Bolivian elections, the official vote counting system that was expected to publish the results real-time, suddenly stopped. When it resumed, the results had flipped. We estimate several difference-in-differences specifications using a 2016 referendum and the votes of other political parties. We find that the extent of the fraud is 2.51% of the valid votes, sufficient to change the outcome of the election. Our results are robust to polling-station-level shocks common across 2019 and …

Characterizing Probabilities Of Outbreaks Of Dengue In Central Argentina Using A Temperature-Dependent Stochastic Model, Morgan H. Jackson, Elizabet L. Estallo, Cheng Ly, Michael A. Robert

Graduate Research Posters

Dengue virus (DENV) causes over 390 million infections and around 40,000 deaths worldwide each year. DENV is primarily transmitted by the mosquito Aedes aegypti, and both the life cycle of these mosquitoes and dengue transmission are significantly impacted by temperature. In the temperate region of Central Argentina, where dengue outbreaks first began in 2009, outbreaks of dengue can only occur due to new introductions of DENV from other regions. Due to the relationships between temperature and dengue, the risk of outbreak changes throughout the year.

We develop a stochastic model including temperature-dependent mosquito life history traits and transmission-related parameters. …

Promoting Understanding Of Three Dimensions Of Science Learning Plus Nature Of Science Using Phenomenon-Based Learning, Maryam Saberi, Noushin Nouri

Teaching and Learning Faculty Publications

The utilization of phenomenon-based learning (PhBL) for science instruction remains limited despite its alignment with the goals outlined in the Next Generation Science Standards (NGSS; NGSS Lead States, 2013) due to the lack of exemplary materials and inadequate training opportunities for teachers. The aim of this article is to illustrate the steps of the PhBL method by providing an exploratory learning experience as it was implemented in a preservice setting. In this study, we provide an innovative perspective by illuminating how this kind of instruction can be used as a context to explicitly discuss the three dimensions of learning (i.e., …

Radiation Force Modeling For A Wave Energy Converter Array, Salman Husain, Gordon Parker, David Forehand, Enrico Anderlini

Michigan Tech Publications

The motivation and focus of this work is to generate passive transfer function matrices that model the radiation forces for an array of WECs. Multivariable control design is often based on linear time-invariant (LTI) systems such as state-space or transfer function matrix models. The intended use is for designing real-time control strategies where knowledge of the model’s poles and zeros is helpful. This work presents a passivity-based approach to estimate radiation force transfer functions that accurately replace the convolution operation in the Cummins equation while preserving the physical properties of the radiation function. A two-stage numerical optimization approach is used, …

Perspective: The Evolution Of Hormones And Person Perception-A Quantitative Genetic Framework, Christopher I Gurguis, Tyler S Kimm, Teresa A Pigott

Faculty, Staff and Student Publications

Evolutionary biology provides a unifying theory for testing hypotheses about the relationship between hormones and person perception. Person perception usually receives attention from the perspective of sexual selection. However, because person perception is one trait in a suite regulated by hormones, univariate approaches are insufficient. In this Perspectives article, quantitative genetics is presented as an important but underutilized framework for testing evolutionary hypotheses within this literature. We note tacit assumptions within the current literature on psychiatric genetics, which imperil the interpretation of findings thus far. As regulators of a diverse manifold of traits, hormones mediate tradeoffs among an array of …

Large T Antigen Mediated Target Gene Replication Improves Site-Specific Recombination Efficiency, Zening Wang, Chuan Chen, Xin Ge

Faculty, Staff and Student Publications

With advantages of high-fidelity, monoclonality and large cargo capacity, site-specific recombination (SSR) holds great promises for precise genomic modifications. However, broad applications of SSR have been hurdled by low integration efficiency, and the amount of donor DNA available in nucleus for SSR presents as a limiting factor. Inspired by the DNA replication mechanisms observed in double-stranded DNA virus SV40, we hypothesized that expression of SV40 large T antigen (TAg) can increase the copy number of the donor plasmid bearing an SV40 origin, and in consequence promote recombination events. This hypothesis was tested with dual recombinase-mediated cassette exchange (RMCE) in suspension …

Computer-Aided Craniofacial Superimposition Validation Study: The Identification Of The Leaders And Participants Of The Polish-Lithuanian January Uprising (1863–1864), Rubén Martos, Rosario Guerra, Fernando Navarro, Michela Peruch, Kevin Neuwirth, Andrea Valsecchi, Rimantas Jankauskas, Oscar Ibáñez

Faculty, Staff and Student Publications

In 2017, a series of human remains corresponding to the executed leaders of the "January Uprising" of 1863-1864 were uncovered at the Upper Castle of Vilnius (Lithuania). During the archeological excavations, 14 inhumation pits with the human remains of 21 individuals were found at the site. The subsequent identification process was carried out, including the analysis and cross-comparison of post-mortem data obtained in situ and in the lab with ante-mortem data obtained from historical archives. In parallel, three anthropologists with diverse backgrounds in craniofacial identification and two students without previous experience attempted to identify 11 of these 21 individuals using …

Outcomes Of Upper Gastrointestinal Bleeding In Hospitalized Covid-19 Patients In The United States: A Propensity-Score Matched Analysis Of A Large National Database, Moon Ryu, Mohammed Quazi, Niloy Ghosh, Karthik Gangu, Amir H Sohail, Asif Farooq, Babu S Maringanti, Aman Goyal, Anupa Patel, Muhammad S Khan, Abu B Sheikh

Faculty, Staff and Student Publications

Patients with cirrhosis that are hospitalized with COVID-19 infection have been found to have worse outcomes. No comparative study has been conducted between gastrointestinal (GI) bleeding in patients with cirrhosis who are diagnosed with COVID-19. We utilized the National Inpatient Sample (NIS) database to perform a retrospective analysis of 24, 050 patients diagnosed with cirrhosis and COVID-19. The identified patients were separated into variceal bleeding, nonvariceal bleeding, and no (or neither) GI bleeding groups. After performing propensity sample matching and multivariate analysis of mortality, we found no significant differences in mortality among the three groups. However, the variceal bleed group …

Combining Neuroimaging And Brain Stimulation To Test Alternative Causal Pathways For Nicotine Addiction In Schizophrenia, Xiaoming Du, Fow-Sen Choa, Joshua Chiappelli, Heather Bruce, Mark Kvarta, Ann Summerfelt, Yizhou Ma, William T Regenold, Kevin Walton, George F Wittenberg, Stephanie Hare, Si Gao, Andrew Van Der Vaart, Zhiwei Zhao, Shuo Chen, Peter Kochunov, L Elliot Hong

Faculty, Staff and Student Publications

The smoking rate is high in patients with schizophrenia. Brain stimulation targeting conventional brain circuits associated with nicotine addiction has also yielded mixed results. We aimed to identify alternative circuitries associated with nicotine addiction in both the general population and schizophrenia, and then test whether modulation of such circuitries may alter nicotine addiction behaviors in schizophrenia. In Study I of 40 schizophrenia smokers and 51 non-psychiatric smokers, cross-sectional neuroimaging analysis identified resting state functional connectivity (rsFC) between the dorsomedial prefrontal cortex (dmPFC) and multiple extended amygdala regions to be most robustly associated with nicotine addiction severity in healthy controls and …

Novel Analog Holographic Wavefront Sensors In A Photopolymer Medium, Emma Branigan

Doctoral

Wavefront sensing is a vital technology that allows for recovery of information and image resolution, from otherwise corrupted signals. Combined with computational systems, wavefront sensors (WFS) enable rapid, accurate measurement of optical distortions, or aberrations. The analog holographic wavefront sensor (AHWFS) is a recent advancement that measures wavefront aberration modes using intensity ratios at paired diffraction spots. The modal AHWFS is an elegant solution to wavefront sensing that is low-cost, highly photon efficient, high speed, and insensitive to scintillation effects.

This work presents the first fabrication of an AHWFS in a self-developing acrylamide-based photopolymer for measuring defocus and spherical aberration. …