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2024

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Phytochemical Screening And Medicinal Properties Of Caralluma Fimbriata And Moringa Oleifera, Ammara Tariq, Anum Ashfaq, Kalsoom Sughra, Ayesha Hameed Dec 2024

Phytochemical Screening And Medicinal Properties Of Caralluma Fimbriata And Moringa Oleifera, Ammara Tariq, Anum Ashfaq, Kalsoom Sughra, Ayesha Hameed

Journal of Bioresource Management

The research was intended to evaluate the medicinal properties of Caralluma fimbriata and Moringa oleifera, as these plants are well known for their therapeutic activities. Qualitative analysis of the phytochemical components of these plants was used to identify the existence of potentially useful therapeutic compounds. Antibacterial and antifungal activities of extracts were assessed and their antioxidant and anti-inflammatory properties were evaluated using the DPPH assay and the protein denaturation inhibition assay, respectively. The α-amylase and α-glucosidase inhibition tests were utilized to determine the plant extract's effectiveness as an antidiabetic agent. Phytochemical analysis showed the presence of medicinally beneficial compounds …


Financial Barriers And Inequity In Medical Education In India: Challenges To Training A Diverse And Representative Healthcare Workforce, Manmeet Ahluwalia Dec 2024

Financial Barriers And Inequity In Medical Education In India: Challenges To Training A Diverse And Representative Healthcare Workforce, Manmeet Ahluwalia

All Publications

India has been historically challenged by an insufficient and heterogeneously clustered distribution of healthcare infrastructure. While resource-limited healthcare settings, such as major parts of India, require multidisciplinary approaches for improvement, one key approach is the recruitment and training of a healthcare workforce representative of its population. This requires overcoming barriers to equity and representation in Indian medical education that are multi-faceted, historical, and rooted in inequality. However, literature is lacking regarding the financial or economic barriers, and their implications on equity and representation in the Indian allopathic physician workforce, which this review sought to describe. Keyword-based searches were carried out …


Balancing Governance And Tradition: Navigating Political, Social, Economic, And Cultural Dynamics In Indonesian Village-Owned Enterprises, Desti Fitriani, Elvia R. Shauki, Mohammad Istiaq Azim Dec 2024

Balancing Governance And Tradition: Navigating Political, Social, Economic, And Cultural Dynamics In Indonesian Village-Owned Enterprises, Desti Fitriani, Elvia R. Shauki, Mohammad Istiaq Azim

ASEAN Journal of Community Engagement

This study examines the complex governance dynamics affecting Indonesian Badan Usaha Milik Desa (BUMDes) [village-owned enterprises], focusing on political, social, economic, and cultural pressures. Using a qualitative multi-case approach, including focus group discussions with 65 participants from West Java and West Nusa Tenggara, Indonesia, the study identified significant challenges: political interference, limited community engagement, economic dependence on government funds, and cultural norms that constrain BUMDes operations. Village elites frequently influence governance, limited capital access, and ingrained cultural values hinder transparency and open dialogue. To address these challenges, this study recommends a comprehensive approach comprising four key strategies: enhancing the institutional …


Examining The Media’S Roles And Responsibilities, An Evaluation Of Nigeria’S Development Toward The Sdgs, Kelvin Inobemhe, Tsegyu Santas, Aminat Trust Ogbesoh Dec 2024

Examining The Media’S Roles And Responsibilities, An Evaluation Of Nigeria’S Development Toward The Sdgs, Kelvin Inobemhe, Tsegyu Santas, Aminat Trust Ogbesoh

ASEAN Journal of Community Engagement

This paper examines the roles and responsibilities in the country’s development toward the Sustainable Development Goals (SDGs). The media in any society is fundamentally a development partner. Whether combating diseases or disseminating critical messages about development plans and actions to the public, the media is a key stakeholder. In Nigeria, the government, in collaboration with development agencies and other relevant stakeholders, has actively sought pathways to actualize the SDGs. The media are among these important stakeholders. The Nigerian press and media to serve the people and development across the nation present a good opportunity. However, this study observes that after …


Educational Strategy For Service Learning Using Stem Activities: A Case Study Of A Malaysian Secondary School, Nurulsaidah Abdul Rahim, Suzaliza Mustafar Dec 2024

Educational Strategy For Service Learning Using Stem Activities: A Case Study Of A Malaysian Secondary School, Nurulsaidah Abdul Rahim, Suzaliza Mustafar

ASEAN Journal of Community Engagement

This paper discusses the Service Learning Malaysia-University for Society (SULAM) program in developing an educational strategy for science, technology, engineering, and mathematics (STEM) learning at a Malaysian secondary school. The implementation of the 60:40 policy (60% STEM and 40% non-STEM) in Malaysia is to increase the number of students studying STEM. However, as of 2022, this policy had failed to achieve this target ratio. Additionally, Malaysian students’ scores on the Program for International Student Assessment (PISA) in the categories of math, science, and language literacy decreased from 2018 to 2022. This paper argues that SULAM represents a promising approach to …


Literacy Story Mapping: Empowering Bogoran Hamlet In Indonesia Through Among E3cho Program, Luky Tiasari, Shanta Rezkita, Vita Tri Wahyuni, Deyas Fito Nurochman, Annisa Hapsari, Dwi Setiawan Dec 2024

Literacy Story Mapping: Empowering Bogoran Hamlet In Indonesia Through Among E3cho Program, Luky Tiasari, Shanta Rezkita, Vita Tri Wahyuni, Deyas Fito Nurochman, Annisa Hapsari, Dwi Setiawan

ASEAN Journal of Community Engagement

This paper outlines the implementation of Among Education, Environment, Economic, Culture, Healthy, and Outcome (Among E3CHO), a community engagement program in Bogoran Hamlet in Trirenggo Region of Bantul Regency, Yogyakarta, Indonesia. Among E3CHO initiative consists of multiple education, environment, economic, culture, and health engagement sessions aimed at generating a literacy story map, Peta Cerita Berliterasi, as an integrated outcome of community capacities. The program development followed community-based research methodologies, starting with the identification of challenges facing by the community using comprehensive questionnaires, followed by multiple community engagement programs. In the program, the health …


Designing A Curriculum And Learning Program For The Creative Industry’S Challenge And Workforce Development, Mochamad Nasrul Chotib, Herditya Wahyu Widodo, Kukuh Prayitno Subagyo, Ahmad Heki Sujiatmoko, Nurenzia Yannuar, Adham Adyatma, Gizka Namira Q. Z., Indira Rizqita Waradani, Juanita Maharani P. Dec 2024

Designing A Curriculum And Learning Program For The Creative Industry’S Challenge And Workforce Development, Mochamad Nasrul Chotib, Herditya Wahyu Widodo, Kukuh Prayitno Subagyo, Ahmad Heki Sujiatmoko, Nurenzia Yannuar, Adham Adyatma, Gizka Namira Q. Z., Indira Rizqita Waradani, Juanita Maharani P.

ASEAN Journal of Community Engagement

This article discusses the importance of developing a learning track to respond to the demands of the creative market industry in the community, particularly with regard to journalism and related content creation. The study is based on a collaborative workshop conducted with practitioners from the Indonesian platform Kapanlagi Youniverse. The results of this preliminary study indicate that designing a curriculum and learning program that aligns with current industry practices is essential for preparing the journalism and creative content workforce. Collaborating with industry practitioners is crucial to competing in the rapidly evolving creative industry. The findings also suggest that incorporating subjects …


The Impact Of Disparities In Housing Cluster Development Regulations On Water Catchment Area Protection (Case Study: Bekasi City), Genta Aulia Ramadhan, Harsanto Nursadi Dec 2024

The Impact Of Disparities In Housing Cluster Development Regulations On Water Catchment Area Protection (Case Study: Bekasi City), Genta Aulia Ramadhan, Harsanto Nursadi

Cities and Urban Development Journal

Background: The development of housing clusters in urban areas is usually becoming a significant factor that affecting environmental conditions, especially in terms of protecting water catchment areas. This also happened in Bekasi City, the high demand for housing resulted in a rapid increase in the development of housing clusters which in some cases were not in line with environmental protection regulations.

Aims: This study aims to analyze the impact of regulatory gaps related to spatial planning and environmental management on the protection of water catchment areas in Bekasi City.

Methods: Using a case study approach, this study analyzes existing policies, …


People-Centered Development In The Aquarium Village Community, Cindy Madayani, Dzaky Kayungyun Ramdhani, Ahmad Za'iimul Chanief Dec 2024

People-Centered Development In The Aquarium Village Community, Cindy Madayani, Dzaky Kayungyun Ramdhani, Ahmad Za'iimul Chanief

Cities and Urban Development Journal

Background: The changing landscape of Jakarta, especially in coastal areas, has sparked heated debates about spatial planning and social justice.

Aims: This study aims to assess the extent to which the basic rights of the residents of Kampung Susun Akuarium are fulfilled, especially in terms of access to public facilities and other basic needs.

Methods: The method used in this study is descriptive qualitative. Primary data were obtained through observation and in-depth interviews with residents and representatives of the Bangkit Mandiri Aquarium Cooperative. Secondary data were collected from relevant literature and previous research results.

Results: Based on the documented interview …


The Strategy Of Taman Mini Indonesia Indah As An Educational Cultural Tourism Destination For Generation Z Students, Yoga Akbar Bramantya Dec 2024

The Strategy Of Taman Mini Indonesia Indah As An Educational Cultural Tourism Destination For Generation Z Students, Yoga Akbar Bramantya

Journal of Indonesian Tourism and Policy Studies

The Merdeka Belajar Program is a new policy of the Ministry of Education and Culture of the Republic of Indonesia that provides students with the freedom to learn, pays attention to their natural talents, and gives teachers and students the freedom to innovate. This program is designed based on the needs and desires of students, and utilizes educational tourism objects as a means of learning. Taman Mini Indonesia Indah (TMII) is one of the educational tourism destinations that is suitable for learning about Indonesian culture and diversity through detailed miniatures. TMII displays miniature traditional houses from various provinces with the …


Curug Cipamingkis Strategy As A Leading Travel Destination In Kesatuan Pemangkuan Hutan (Kph) Perhutani Bogor, Nurazahra Dwi Putri Dec 2024

Curug Cipamingkis Strategy As A Leading Travel Destination In Kesatuan Pemangkuan Hutan (Kph) Perhutani Bogor, Nurazahra Dwi Putri

Journal of Indonesian Tourism and Policy Studies

This research discusses the promotion strategy for the Cipamingkis Waterfall as a famous destination at the Kesatuan Pemangku Hutan (KPH) Perhutani Bogor with the aim of knowing how to promote Cipamingkis Waterfall in utilizing its tourism potential. This research was conducted when the author did an internship for 3 months. The research method used is descriptive qualitative with data collection techniques based on observations, interviews with managers, conducting direct surveys to destinations and literature studies or literature studies according to the theme. The results from the promotional strategy carried out by Cipamingkis Waterfall are quite good and must be maintained, …


Speculations On Brunelleschi’S Pazzi Chapel, Howard A. Risatti Professor Emeritus, Donald Schrader Dec 2024

Speculations On Brunelleschi’S Pazzi Chapel, Howard A. Risatti Professor Emeritus, Donald Schrader

Art Inquiries

Why speculate on Filippo Brunelleschi’s Pazzi Chapel? As Giorgio Vasari wrote, many of Brunelleschi’s projects were not finished in his lifetime and not as he wished. The lesson to be drawn, says Vasari, who was writing a century after Brunelleschi’s death, is that “anyone who wishes to leave a memorial of his existence should complete it in his own lifetime and not put faith in anyone else.” Since Brunelleschi died well before the chapel was completed, issues have been raised for over a century about its inconsistencies regarding the open loggia, the barrel-vaulted portico, and the façade. This paper addresses …


Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker Dec 2024

Treating Chronic Low Back Pain And Plantar Fasciitis With Myokinesthetic System: A Case Study, Sadie Buboltz-Dubs, Russell Baker

Clinical Practice in Athletic Training

The purpose of this case study was to report the effects of the MyoKinesthetic (MYK) System on the pain and function of a collegiate softball player previously diagnosed with chronic non-specific low back pain and foot pain. The patient had been experiencing bilateral foot pain since childhood and conservative treatment options had failed to resolve her pain long term. Additionally, the patient had been experiencing persistent back tightness and soreness. Upon arrival at the university, the patient was evaluated using the MYK postural analysis to identify if a primary nerve root dysfunction could be the cause of her pain. The …


Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz Dec 2024

Head-To-Head Comparison Of Aptamer- And Antibody-Based Proteomic Platforms In Human Cerebrospinal Fluid Samples From A Real-World Memory Clinic Cohort, Raquel Puerta, Amanda Cano, Pablo García-González, Fernando García-Gutiérrez, Maria Capdevila, Itziar De Rojas, Clàudia Olivé, Josep Blázquez-Folch, Oscar Sotolongo-Grau, Andrea Miguel, Laura Montrreal, Pamela Martino-Adami, Asif Khan, Adelina Orellana, Yun Ju Sung, Ruth Frikke-Schmidt, Natalie Marchant, Jean Charles Lambert, Maitée Rosende-Roca, Montserrat Alegret, Maria Victoria Fernández, Marta Marquié, Sergi Valero, Lluís Tárraga, Carlos Cruchaga, Alfredo Ramírez, Mercè Boada, Bart Smets, Alfredo Cabrera-Socorro, Agustín Ruiz

Faculty, Staff and Student Publications

High-throughput proteomic platforms are crucial to identify novel Alzheimer’s disease (AD) biomarkers and pathways. In this study, we evaluated the reproducibility and reliability of aptamer-based (SomaScan® 7k) and antibody-based (Olink® Explore 3k) proteomic platforms in cerebrospinal fluid (CSF) samples from the Ace Alzheimer Center Barcelona real-world cohort. Intra- and inter-platform reproducibility were evaluated through correlations between two independent SomaScan® assays analyzing the same samples, and between SomaScan® and Olink® results. Association analyses were performed between proteomic measures, CSF biological traits, sample demographics, and AD endophenotypes. Our 12-category metric of reproducibility combining correlation analyses identified 2428 highly reproducible SomaScan CSF measures, …


Contents Of Vol. 31, No.3, December 2024, Yuniardini Wimardhani Dec 2024

Contents Of Vol. 31, No.3, December 2024, Yuniardini Wimardhani

Journal of Dentistry Indonesia

This is contents of Vol. 3 2024, December 2024


Road To Progress Or Bumpy Detour? Jeepney Drivers’ Lived Experiences Amidst Ongoing Phaseout, Reignchielle Jcynd D. Lacsina, Ivan Karlo S. Pating, Marjorie L. Paloma, Joy F. Galleon Dec 2024

Road To Progress Or Bumpy Detour? Jeepney Drivers’ Lived Experiences Amidst Ongoing Phaseout, Reignchielle Jcynd D. Lacsina, Ivan Karlo S. Pating, Marjorie L. Paloma, Joy F. Galleon

Sinaya: A Philippine Journal for Senior High School Teachers and Students

This study utilizes a phenomenological research design to explore the lived experiences of jeepney drivers amidst the ongoing government’s initiative to phase out and modernize traditional jeepneys in the Philippines. It focused on six jeepney drivers operating in the Tarlac public transportation system, selected based on specific inclusion criteria. The Theory of Change was used to delve deeper into the findings, revealing that the government's initiatives have challenged the stability of jeepney drivers’ livelihood during the modernization transition. Their lives were in jeopardy due to this abrupt transformation. It left them powerless to adapt to the changes or boycott. The …


The Reel Narrative: The Portrayal And Consequent Archetypes Of Women In Selected Mainstream Philippine Romantic Cinema, Ma. Beatrice P. Pilar, Nathaniel Rey D. Ferrer Dec 2024

The Reel Narrative: The Portrayal And Consequent Archetypes Of Women In Selected Mainstream Philippine Romantic Cinema, Ma. Beatrice P. Pilar, Nathaniel Rey D. Ferrer

Sinaya: A Philippine Journal for Senior High School Teachers and Students

In Philippine society, media, particularly romance films, shapes and reinforces audiences’ perspectives, perpetuating preconceived notions and stereotypical beliefs. However, there is a lack of textual analysis within Filipino films, especially regarding female representation in media. Hence, our study explores the portrayal of female main characters in romance films. Textual film analysis, grounded in Carl Jung’s Jungian archetypes and Jean Shinoda Bolen’s female archetypes in media, was implemented on the six Filipino highest-grossing romance films from 2014 until 2019. This analysis, further supported by a feminist lens, aimed to identify the character portrayal and archetypes of the main female characters in …


Editorial Message Dec 2024

Editorial Message

Issues in Religion and Psychotherapy

No abstract provided.


Gender Rebellion: Gender Non-Conformity As An Act Of Resistance In The Hunger Games, Julia Koncurat Dec 2024

Gender Rebellion: Gender Non-Conformity As An Act Of Resistance In The Hunger Games, Julia Koncurat

Criterion: A Journal of Literary Criticism

No abstract provided.


“Whilst In The Walrus Suit, You Must Be A Walrus”: Human-To-Animal Transformation Through Body Modification And Performance In Kevin Smith’S Tusk, Ahmet Ergün Dec 2024

“Whilst In The Walrus Suit, You Must Be A Walrus”: Human-To-Animal Transformation Through Body Modification And Performance In Kevin Smith’S Tusk, Ahmet Ergün

Criterion: A Journal of Literary Criticism

No abstract provided.


Full Issue Dec 2024

Full Issue

BYU Law Review

No abstract provided.


Inter-Institutional Analysis Of Skin Of Color Representation In Dermatological Lecture Content At Md And Do Medical Schools, Oluwafunke O. Ogunremi, Blake Fredericksen, John Komas, Sana F. Ismail, Siri Knusten-Larson, Valeriy Kozmenko, Afia Albin Dec 2024

Inter-Institutional Analysis Of Skin Of Color Representation In Dermatological Lecture Content At Md And Do Medical Schools, Oluwafunke O. Ogunremi, Blake Fredericksen, John Komas, Sana F. Ismail, Siri Knusten-Larson, Valeriy Kozmenko, Afia Albin

Student Publications

The purpose of this study was to analyze the lecture materials provided in medical schools through a diversity lens. Skin pathologies manifest distinctively on various shades of skin and physicians must be equipped with the proper knowledge to identify and diagnose these conditions accurately and promptly. For most medical students, images in prominent textbooks and lecture slides are their first encounter with disease presentations. Therefore, it is important to analyze the diversity of skin tones in the content that is being delivered. Specifically, the use of images featuring darker skin tones compared to those depicting lighter skin tones. This study …


Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai, Lu Lu, Noriaki Ono, Joshua D Welch Dec 2024

Linking Transcriptome And Morphology In Bone Cells At Cellular Resolution With Generative Ai, Lu Lu, Noriaki Ono, Joshua D Welch

Faculty, Staff and Student Publications

Recent advancements in deep learning (DL) have revolutionized the capability of artificial intelligence (AI) by enabling the analysis of large-scale, complex datasets that are difficult for humans to interpret. However, large amounts of high-quality data are required to train such generative AI models successfully. With the rapid commercialization of single-cell sequencing and spatial transcriptomics platforms, the field is increasingly producing large-scale datasets such as histological images, single-cell molecular data, and spatial transcriptomic data. These molecular and morphological datasets parallel the multimodal text and image data used to train highly successful generative AI models for natural language processing and computer vision. …


Dynamic And Concordance-Assisted Learning For Risk Stratification With Application To Alzheimer’S Disease, Wen Li, Ruosha Li, Ziding Feng, Jing Ning Dec 2024

Dynamic And Concordance-Assisted Learning For Risk Stratification With Application To Alzheimer’S Disease, Wen Li, Ruosha Li, Ziding Feng, Jing Ning

Faculty, Staff and Student Publications

Dynamic prediction models capable of retaining accuracy by evolving over time could play a significant role for monitoring disease progression in clinical practice. In biomedical studies with long-term follow up, participants are often monitored through periodic clinical visits with repeat measurements until an occurrence of the event of interest (e.g. disease onset) or the study end. Acknowledging the dynamic nature of disease risk and clinical information contained in the longitudinal markers, we propose an innovative concordance-assisted learning algorithm to derive a real-time risk stratification score. The proposed approach bypasses the need to fit regression models, such as joint models of …


Educating Mental Healthcare Staff On Using The Phq-9 In Telehealth, Anoopa M. Jacob Dec 2024

Educating Mental Healthcare Staff On Using The Phq-9 In Telehealth, Anoopa M. Jacob

Walden Dissertations and Doctoral Studies

I developed a quality improvement staff educational program aimed at addressing the inconsistent use of the Patient Health Questionnaire (PHQ-9) at the project facility, which could adversely affect the quality and continuity of patient care. The need for the program was prompted by the increasing use of telehealth services and the necessity for consistent mental health evaluation tools. I aimed to educate mental health staff about evidence-based practices using the PHQ-9 in telehealth to enhance the quality of care for patients with depression in remote settings. Analytical methods included administering pre- and postintervention tests to measure changes in staff knowledge …


Educating Mental Healthcare Staff On Using The Phq-9 In Telehealth, Anoopa M. Jacob Dec 2024

Educating Mental Healthcare Staff On Using The Phq-9 In Telehealth, Anoopa M. Jacob

Walden Dissertations and Doctoral Studies

I developed a quality improvement staff educational program aimed at addressing the inconsistent use of the Patient Health Questionnaire (PHQ-9) at the project facility, which could adversely affect the quality and continuity of patient care. The need for the program was prompted by the increasing use of telehealth services and the necessity for consistent mental health evaluation tools. I aimed to educate mental health staff about evidence-based practices using the PHQ-9 in telehealth to enhance the quality of care for patients with depression in remote settings. Analytical methods included administering pre- and postintervention tests to measure changes in staff knowledge …


“Religion’S Firm-Rooted Truths:” Richard Polwhele, Pulpit Oratory And Loyalist Romanticism In The English Province, Dafydd Moore Dec 2024

“Religion’S Firm-Rooted Truths:” Richard Polwhele, Pulpit Oratory And Loyalist Romanticism In The English Province, Dafydd Moore

School of Law, Humanities and Social Sciences

This article explores the rearguard action fought by the clergyman and writer Richard Polwhele against what he saw as the threat of Anglican Evangelicalism and Methodism in Cornwall during the French Revolutionary period, highlighting the connections between religious experience, rhetorical performance and politics. Whether it be through his theorizing of pulpit oratory, his rows with those he considered Enthusiasts or his understanding of ordination oaths, Polwhele maintained that religious belief should be regulated by rhetorical distance. Explaining this stance, the article shows how Polwhele’s theological and ecclesiological opposition to the Enthusiasm he regarded as dangerously inherent in Evangelical Protestantism also …


The Implementation Of Behaviour Change Practices In Physical Activity Referral Schemes: A Narrative Review, John Downey, Katie Shearn, Nicola Brown, Ross Wadey, Jeff Breckon Dec 2024

The Implementation Of Behaviour Change Practices In Physical Activity Referral Schemes: A Narrative Review, John Downey, Katie Shearn, Nicola Brown, Ross Wadey, Jeff Breckon

School of Nursing and Midwifery

BackgroundPhysical activity referral schemes have been used extensively as one pathway to support behaviour change in people with long term conditions. Best practice guidance, across countries, recommend that schemes use behaviour change practices. The effectiveness of these schemes is inconsistent, yet, little is known about the implementation of specific approaches, or what influences practitioner’s delivery. This article provides a narrative review of evidence exploring the implementation of behaviour change practices in physical activity referral schemes.MethodsAn electronic search of three databases (PubMed, Scopus, Google Scholar) was undertaken. A menu of iterative techniques was also applied from the CLUSTER approach to increase …


Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu Dec 2024

Disruption Of Distal Appendage Protein Cep164 Causes Skeletal Malformation In Mice, Hiroyuki Yamaguchi, Megumi Kitami, Margaret Li, Sowmya Swaminathan, Radbod Darabi, Ken-Ichi Takemaru, Yoshihiro Komatsu

Faculty, Staff and Student Publications

The primary cilium is a cellular antenna to orchestrate cell growth and differentiation. Deficient or dysfunctional cilia are frequently linked to skeletal abnormalities. Previous research demonstrated that ciliary proteins regulating axoneme elongation are essential for skeletogenesis. However, the role of the ciliary proteins responsible for initiating cilium assembly in skeletal development remains unknown. Here, we investigate the function of centrosomal protein of 164 kDa (CEP164), a key ciliogenesis regulator that localizes at the distal appendages of the mother centriole, during skeletal development in mice. Interestingly, the mesodermal cell-specific Cep164 deletion resulted in severe bone defects and osteoblast-specific deletion of Cep164 …


Beyond Status Quo: Why Is Transdisciplinary Communication Instrumental In Disruptive Innovation? [Peer-Review Journal], James Lipuma, Cristo Leon Dec 2024

Beyond Status Quo: Why Is Transdisciplinary Communication Instrumental In Disruptive Innovation? [Peer-Review Journal], James Lipuma, Cristo Leon

STEM for Success Resources

Explore "Beyond Status Quo: Why is Transdisciplinary Communication Instrumental in Innovation?" by James Lipuma and Cristo Leon. This groundbreaking research highlights the role of transdisciplinary communication in overcoming disciplinary silos, fostering collaboration, and driving disruptive innovation. Learn how these strategies enable systemic change, address societal challenges, and create impactful solutions. Published in the Journal of Systemics, Cybernetics, and Informatics (Vol. 22, No. 7, 2024). Read more about the transformative potential of inclusive research environments and collaborative frameworks.