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A Mixed Methods Approach To Evaluation And Modeling Of Ergonomic Stressors Due To Mass Decedent Handling, Vaishakhi Suresh

Graduate Theses, Dissertations, and Problem Reports (ETD)

Work-related injuries, illnesses, and musculoskeletal disorders (MSDs) significantly impact the U.S. healthcare industry, leading to lost working days, high medical costs, and increased turnover rates among healthcare workers (HCWs). Increased physical and mental health risks due to the handling of deceased during COVID-19 pandemic has exacerbated these issues. While the ergonomic risks of patient handling are well-studied, limited research exists on the ergonomic risks of manual handling of the deceased. Therefore, the primary objective of this study was to explore the challenges associated with decedent handling so that effective safety interventions to reduce the risk of injury and mental distress …

New Associate Editors, S. Nicole Frey

Human–Wildlife Interactions

New associate editors include Neil Jordan and Allen Rutberg.

In Silico Identifcation Of New Potential Inhibitors Of Quorum Sensing By Gram‑Positive Bacteria Through Specialized Molecular Docking, Amgad Albohy, Najla A. Obaid, Mariam Mojally, Mohammed Abou Rehab, Najd Ahmad Alkhudhir

Pharmacy

Quorum sensing is the process by which bacterial cells can communicate by producing substances to regulate viable processes such as gene expression, virulence, and bioflm formation. Gram-positive bacteria such as Staphylococcus aureus and Enterococcus faecalis have specifc enzymes (autoinducers) that control the quorum sensing system. Sortase A is a surface protein that regulates virulence and cell‒cell communication in Gram-positive bacteria. To interfere with this system and reduce virulence and cell‒cell communication, quorum sensing inhibitors are used, which are nonantibiotic substances. In this study, we aimed to use Food and Drug Administration-approved drugs (analgesics and antipsychotics) and investigate their activity using …

Chemical Synthesis And Biological Application Of Sensitive Rna, Alexander T. Apostle

Dissertations, Master's Theses and Master's Reports

In the field of epigenetics - the dynamic collection of chemical modifications that overlay DNA/RNA - there is increasing interest in the potential for therapeutic and research-based utilization of the epitranscriptomics: those epigenetic modifications specific to RNA. Epitranscriptomics can give us a new approach to understanding and treating RNA viruses, like SARS-CoV-2. Given viruses are often found modified by human epitranscriptomic machinery, understanding how these modifications can modulate virulence is of high interest. We have shown that the N1-methyladensoine modification causes RNA synthesis termination in the SARS-CoV-2 replication complex, and thus may explain the differences in symptoms observed in individuals. …

Combatting The Rising Rate Of Sti Cases In San Diego, Ca, Tracy Tuong

Selected Social Change Portfolios in Prevention, Intervention, and Consultation

Goal Statement: The goal of this social change portfolio is to combat the rise in transmission rates of sexually transmitted infections (STIs) through increasing access to education on sexual health and quality health care, including contraceptives and STI testing. Significant Findings: San Diego has seen a rise in the spread of STIs, disproportionately affecting young men and women of color. This rise can be attributed to risk factors such as low socioeconomic status (SES), discrimination, and lack of access to quality healthcare or prevention services. Working to reduce the social stigma associated with STIs, providing quality sexual health education, and …

The Role Of Place Of Birth And Residence In Puerto Rican Health Disparities: Evidence From Disability Prevalence Among Archipelago- Vs. Mainland-Born Puerto Ricans, Mara Getz Sheftel, Frank W. Heiland

Publications and Research

Objectives: This paper provides new estimates of disability prevalence for the archipelago and mainland-residing Puerto Rican populations ages 40 and above and compares disability by place of birth and place of residence to investigate drivers of middle and older age health.

Methods: Large nationally representative samples from 2013 to 2017 American Community Survey and Puerto Rico Community Survey data are used to estimate age-specific disability prevalence for archipelago-born/archipelago-residing, archipelago-born/mainland-residing, mainland-born/mainland-residing Puerto Ricans.

Results: Mainland-born/ mainland-residing Puerto Ricans have the lowest age-adjusted disability rates and archipelago-born/archipelago-residing Puerto Ricans have the highest rates. Differences in education explain part of this disparity.

Discussion: …

ปัจจัยคัดสรรที่มีความสัมพันธ์กับภาวะไข้จากเม็ดเลือดขาวต่ำ ในผู้ป่วยมะเร็งต่อมน้ำเหลืองที่ได้รับยาเคมีบำบัด, ปรียาภรณ์ หงส์พิมลมาศ, สุรีพร ธนศิลป์

Journal of Nursing Research, Innovation, and Health

วัตถุประสงค์: เพื่อศึกษาภาวะไข้จากเม็ดเลือดขาวต่ำ และความสัมพันธ์ของอายุ เพศ ระดับ Albuminในเลือด พฤติกรรมการดูแลตนเอง  ชนิดของโรค ระยะของโรคมะเร็ง จำนวนครั้งที่ได้รับเคมีบำบัด โรคร่วม และกิจกรรมทางกาย กับภาวะไข้จากเม็ดเลือดขาวต่ำในผู้ป่วยมะเร็งต่อมน้ำเหลืองที่ได้รับยาเคมีบำบัด ของผู้ป่วยมะเร็งต่อมน้ำเหลืองที่ได้รับยาเคมีบำบัด

รูปแบบการวิจัย: การศึกษาครั้งนี้เป็นการวิจัยเชิงพรรณนา

วิธีดำเนินการวิจัย: กลุ่มตัวอย่าง คือ ผู้ป่วยมะเร็งต่อมน้ำเหลืองที่มาใช้บริการในแผนกผู้ป่วยนอกคลินิกโลหิตวิทยา โรงพยาบาลจุฬาลงกรณ์ จำนวน 114 คน เครื่องมือที่ใช้ในการวิจัย ประกอบด้วย แบบสอบถามพฤติกรรมการดูแลตนเอง และแบบสอบถามกิจกรรมทางกาย ตรวจสอบความตรงตามเนื้อหาได้ 1.0 เท่ากัน และตรวจสอบความเที่ยงได้ ค่าสัมประสิทธิ์แอลฟาของครอนบาคเท่ากับ 0.76 และ 0.72 ตามลำดับ วิเคราะห์ข้อมูลด้วยสถิติพรรณนา และวิเคราะห์การถดถอยโลจิสติค ผลการศึกษา: พบว่ามีผู้ป่วยมะเร็งต่อมน้ำเหลืองที่ได้รับยาเคมีบำบัดเกิดภาวะไข้จากเม็ดเลือดขาวต่ำร้อยละ 34.2 ส่วนใหญ่เกิดในครั้งแรกของการได้รับยาเคมีบำบัด ร้อยละ 48.7 และเกิดภาวะไข้จากเม็ดเลือดขาวต่ำเพียง 1 ครั้ง คิดเป็นร้อยละ 84.6 โดยปัจจัยที่มีความสัมพันธ์ทำให้ผู้ป่วยมะเร็งต่อมน้ำเหลืองเกิดภาวะไข้จากเม็ดเลือดขาวต่ำมากขึ้น ได้แก่ เพศหญิง ผู้ที่มีอายุ 60 ปีขึ้นไป ระดับอัลบูมินในเลือดต่ำ(<3.5 g/dL) เป็นมะเร็งต่อมน้ำเหลืองระยะแพร่กระจาย จำนวนครั้งที่ได้รับยาเคมีบำบัด และการมีโรคร่วม (OR=5.43, 1.68, 4.76, 1.62, 1.83, 2.33 ตามลำดับ p<.05) และปัจจัยที่มีความสัมพันธ์ทำให้เกิดภาวะไข้จากเม็ดเลือดขาวต่ำลดลง คือ กิจกรรมทางกาย(OR= 0.58, p<.05) ส่วนปัจจัยที่ไม่มีความสัมพันธ์กับภาวะไข้จากเม็ดเลือดขาวต่ำ ได้แก่ พฤติกรรมการดูแลตนเอง และชนิดของโรคมะเร็ง(OR=0.62, 1.15 ตามลำดับ p >.05)

The Role Of Renal Resistive Index (Rri) As Early Non Invasive Predictor Of Renal Dysfunction And Relation To Estimated Gfr In Nafld Patients, Atteyat Aboelmaged Semeya, Hala Abd-Elhameed Tabl, Naglaa F. Al-Mihy

Journal of Medicine in Scientific Research

Background: Non-alcoholic fatty liver (NAFLD) is the diagnosis of fatty infiltration of the liver (steatosis) in the absence of other reasons, done through histology or imaging, with or without fibrosis or inflammation. We sought to ascertain the function of RRI as early non-invasive predictor of renal dysfunction and the relationship between eGFR and RRI in patients with NAFLD.

Methods: This cross-sectional research comprised 250 patients and controls gathered from outpatient clinic of the Hepatogasteroenterology Department, Benha teaching Hospitals. They were split into three groups: group 1 consisted of 100 NASH patients, fibrosis-free or with a history of the condition; group …

Serum Procalcitonin As An Early Marker Of Diabetic Foot Sepsis In Shebin Elkom Teaching Hospital, Asmaa M Soliman, Shimaa M W Kalama, Rania T H Gebba, Randa I. Ahmed Elshiha, Samah Mohammed Abdelmonem Abu Sholaa, Elham T Awwad, Mohamed Ramzy Alawy, Mohamed Abdel Samie Abdelkhalek Elbahat

Journal of Medicine in Scientific Research

Background Diabetic foot infections are a serious consequence of diabetes mellitus, frequently resulting in major health problems such as amputation. Traditional diagnostic markers such as C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) have limitations, spurring more research into procalcitonin (PCT) as a possibly more reliable predictor of infection severity and consequences. Objectives To compare the efficacy of (PCT) to standard inflammatory indicators (ESR and CRP) in predicting outcomes of acute diabetic foot infections (DFI) and to determine its potential benefits in clinical settings. Patient and Methods A cross-sectional study was undertaken at Shebin Elkom Teaching Hospital between December 2023 …

Practice Change By Implementing A Standardized Checklist During Informed Consent And Improving Effective Communication, Patient Understanding And Satisfaction, And Continued Enrollment, Simone Shirley

Doctor of Nursing Practice (DNP)

Informed consent discussions are often one of the first steps in a medical treatment plan of care. Literature has shown effective communication and a standardized checklist, used as a guide by the consenter to ensure all mandated elements of informed consent are discussed, will help potential research participants make an informed decision. The purpose of this clinical project is to implement a standardized checklist that guides consenters during the informed consent process at a pediatric, hematology, and oncology hospital. The project focused only on therapeutic studies. The consenter performed two informed consent conversations without any prior education on the standardized …

Informed Consent For Research : A Clinical Practice Change Project, Wendy Hayes

Doctor of Nursing Practice (DNP)

The informed consent process for research is lengthy and cumbersome. The number of required elements for informed consent and the increasing complexity of clinical trials make it difficult to achieve effective and valid informed consent. There were two aims of this clinical project. The first aim was to implement a standardized checklist for consenters to use during informed consent discussions to increase effective communication and the inclusion of all the required elements of consent. The second aim was to determine if the implementation of a standardized checklist by consenters increased the understanding of the required elements of consent, increased satisfaction …

Scaffold Hopping For The Lead Optimization Of The Orally Active Antileishmanial Pyrrolo-Quinazoline Alkaloid Natural Product Peganine, Sunitha Jada

Electronic Theses and Dissertations

Leishmaniasis is a protozoan parasitic disease caused by the species Leishmania that affects millions of people around the world. It is a serious public health concern in the developing world with about 1 million cases and 70,000 fatalities occurring each year. It has several forms with visceral, and cutaneous leishmaniasis being the most common forms of the disease. Visceral leishmaniasis, caused by the Leishmania donovani occurs mainly in Brazil, Eastern Africa, and India, and is fatal if left untreated. The current treatments for leishmaniasis such as pentavalent antimonials, amphotericin B, miltefosine, paromomycin, pentamidine, and some azoles suffer from serious drawbacks. …

Scalp Fast Oscillation As A Predictor For Epilepsy In Critically Ill Patients With Periodic Discharges, Kongpop Sutantikorn

Chulalongkorn University Theses and Dissertations (Chula ETD)

Introduction: Periodic discharges (PDs) in critically ill patients due to diverse pathologies are not uncommon and carry varied prognosis. Scalp fast oscillations (SFOs) have been increasingly studied its association with clinical outcomes in many conditions. However, none has assessed its values in prognostication of the critically ill patients. Objectives: To assess the prognostic values of SFOs in prediction of short and long-term clinical outcomes in critically ill patients with PDs. Materials and Methods: All patients aged > 15 years with detection of PDs during 2014-2022 were recruited. Converted electroencephalography (EEG) files to the standard format were used for analysis. Time-frequency analysis …

Perception, Awareness, And Practices Toward The Pm2.5 During The Air Pollution Episode Among Chinese Students In Bangkok And Vicinity, Thailand: A Cross-Sectional Study, Jiali Chen

Chulalongkorn University Theses and Dissertations (Chula ETD)

Air pollution poses a significant public health threat to urban populations worldwide. Mobile groups such as international students face unique vulnerabilities, but their risk adaptation capacity remains understudied. This study assessed awareness, perception, and protective measures of PM2.5 among Chinese international students in Bangkok and its vicinity. This study used a validated scale to conduct a cross-sectional survey of 393 participants. The results revealed that while students exhibited a high level of risk perception regarding air pollution (mean score: 48.0 ± 7.6), their awareness was relatively low (mean score: 6.3 ± 2.9), with only 3.8% of respondents demonstrating "high awareness". …

University Of New Mexico Health Sciences Center Discovery Research Annual Report 2024, Michael Haederle, Claire Hannon, Nicole San Roman, Jett Loe, Sara Mota, Sarah Head

Research Annual Reports

Annual research report from the University of New Mexico Health Sciences Center.

Clinical Study Of Combined Arthroscopic Drilling And Platelet Rich Plasma Injection In Knee Osteochondral Lesions In Middle-Aged Patients, Mohamed Salah Labib Mohamed, Mohamed Abd Elmoneam Gafar

Journal of Medicine in Scientific Research

Background: Osteochondral lesions commonly occur in the knee joints and causes detrimental effects on the quality of life. Arthroscopic drilling is the treatment option for mild to moderate lesions. However, it is debatable whether regenerated cartilage from arthroscopic drilling surgery is durable. It is speculated that induction of chondrocyte differentiation from subchondral mesenchymal stem cells is facilitated by platelet-rich plasma (PRP), which is a rich source of diverse growth factors.

Aim of work: To evaluate the procedures of combined arthroscopic drilling and PRP injection intra-articularly for mild to moderate knee osteochondral lesions management.

Patients and Methods: This randomized prospective study …

Short Term Effects Of Bariatric Surgeries On Renal And Hepatic Functions On Obese Morbid Patients, Naglaa F. Al-Mihy, Esayed Elmokadem, Atteyat Aboelmaged Semeya

Journal of Medicine in Scientific Research

Background: Bariatric surgery has emerged as a well-established treatment for achieving long-lasting and successful weight reduction. Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are currently the most frequently done operations. The aim of this research was to investigate the hepatic and renal alterations following bariatric procedures, with a particular focus on SG.

Methods: This observational prospective cohort research was performed on 100 morbidly obese individuals with BMI ≥40 kg/m² who underwent SG. All patients were evaluated before surgery clinically and all laboratory investigations were done before operation as baseline, 3 months, 6 months after surgery, and after one …

Introducing Comprehensive Sexuality Education And Hiv Prevention And Treatment Methods Through Pop-Up Clinics To Secondary School Girls In Kwazulu-Natal, South Africa, Eliza I. Tobin, Joaquin Carlos Pinga, Caitlyn Stanya

Capstone Showcase

Human immunodeficiency virus (HIV) is a retrovirus that attacks the immune system leading to people living with HIV (PLHIV) immunodeficient and more susceptible to other infections or diseases (UNAIDS, 2023b). This can lead to acquired immunodeficiency syndrome (AIDS) within 8-10 years of infection (UNAIDS, 2023b). HIV does not always present symptoms, making it hard for people to identify their HIV status without proper screening. The lack of awareness around a person’s status has led HIV to spread worldwide. In addition to the worldwide spread of HIV, there is no cure for the disease, however, antiretroviral therapy (ART) is mainly used …

Copper Resistance In Staphylococcus Epidermidis: Role Of The Multicopper Oxidase Gene, Caroline Sundal

Scripps Senior Theses

The ongoing struggle against antibiotic resistance and the lack of new antibiotic discoveries being made is a threat to global health. Alternate forms of antibacterial treatment are an important area of research to increase the treatment efficacy of clinical antimicrobial applications. In this research paper, we examine the model organism Staphylcoccus epidermidis, one of the leading causes of nosocomial infection. S. epidermidis normally resides on skin and mucus, however, can become an opportunistic pathogen if it invades the body, entering the bloodstream via the insertion of medical and prosthetic devices. Copper was a traditional therapy in ancient Egypt used for …

Migration-Associated Variation In Blood Parasitism, Body Condition, And Stress In Gambel’S White-Crowned Sparrows (Zonotrichia Leucophrys Gambelii), Julianna Deibel

Scripps Senior Theses

Migration is a widespread behavior in animals which both causes and is motivated by fluctuations in nutrient availability. Migration is ecologically important, as it connects areas of differing primary productivities and carries pathogens over distance. The relationship between migration and disease is complex, sensitive to anthropogenic disturbance, and influenced by ecological cycles as well as host, vector and parasite life cycles. Four central migration-infection mechanisms have been proposed: migratory susceptibility, migratory exposure, migratory escape, and migratory culling. These mechanisms may yield increased or decreased infection post-migration, based on migration’s physiological tax and the concentration of pathogens along migratory pathways.

To …

Concepts In Animal Parasitology, Chapter 07: Biostatistics For Parasitologists: A Painless Introduction [Parascript Approaches], Jenő Reiczigel, Marco Marozzi, Fábián Ibolya, Lajos Rózsa

Concepts in Animal Parasitology

Covers biostatistics for parasitologists and includes discussion of taking samples, frequency distribution of host individuals across infection classes, sample size, prevalence, mean intesity, median intensity, stochasic equality of intensities, abundance, crowding, levels of aggregation, parasite sex ratio, parasite species richness, interactions between parasite species, and the tool Quantitative Parasitology on the Web (QPweb).

Chapter 7 in Concepts in Animal Parasitology on biostatistics for parasitologists by Jenő Reiczigel, Marco Marozzi, Fábián Ibolya, and Lajos Rózsa. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap007

Concepts In Animal Parasitology, Chapter 58: Acanthocephala Rudolphi, 1808 (Phylum), Scott Monks

Concepts in Animal Parasitology

An overview of the phylum Acanthocephala Rudolphi, 1808, also called the thorny-headed or spiny-headed worms, including discussion of their general morphology, life cycles, classification, and phylogenetic relationships.

Chapter 58 in Concepts in Animal Parasitology, by Scott Monks. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap058

Research News, Publications, 2024, Volume 2, Soumyajit Majumdar

Publications (2015-)

Publications that appeared during the period of April 1 through June 30, 2024.

A Health Needs Assessment Of An Unhoused Population To Influence Policies And Procedures Within An Rn-Run Clinic, Freedom Kelley, Sarah Madison

Doctor of Nursing Practice Projects

Unstable housing is a well-documented and significant risk factor for poor health outcomes. Unhoused persons have higher rates of morbidity and mortality when compared to the general population (Onapa et. al, 2021). This DNP project aims to improve understanding of, and quality of care delivered to this vulnerable population through a health needs assessment of unhoused men and using the results to influence policies and procedures of a new RN-run health clinic within a homeless shelter. The needs assessment followed a cross-sectional survey design, residents were interviewed about their unique health needs. The responses were individually reviewed and coded to …

Quality Improvement Project: Improving Patient Written Discharge Instruction To Reduce The Incidence Of Surgical Site Infection In Ambulatory Surgery Center, Gayane Abramyan

Doctor of Nursing Practice Projects

Surgical site infections (SSIs) are a major global health concern, affecting many people and creating a significant epidemiological and financial burden. Evidence suggests that half of hospital readmissions might be prevented if patients received better discharge instructions and education. After learning about the increased cases of SSIs in patients at the Ambulatory Surgery Center (ASC) and finding a gap in discharge instruction, the Principal Investigator (PI) initiated a quality improvement project (QIP). This QIP aimed to create a new, easily understandable, actionable, and readable discharge instruction to reduce the incidence of SSIs at the ASC. There were two principal interventions: …

Nano-Pulse Treatment Overcomes The Immunosuppressive Tumor Microenvironment To Elicit In Situ Vaccination Protection Against Breast Cancer, Anthony Nanajian, Megan Scott, Niculina I. Burcus, Brittney L. Ruedlinger, Edwin A. Oshin, Stephen J. Beebe, Siqi Guo

Bioelectrics Publications

We previously reported that nano-pulse treatment (NPT), a pulsed power technology, resulted in 4T1-luc mammary tumor elimination and a strong in situ vaccination, thereby completely protecting tumor-free animals against a second live tumor challenge. The mechanism whereby NPT mounts effective antitumor immune responses in the 4T1 breast cancer predominantly immunosuppressive tumor microenvironment (TME) remains unanswered. In this study, orthotopic 4T1 mouse breast tumors were treated with NPT (100 ns, 50 kV/cm, 1000 pulses, 3 Hz). Blood, spleen, draining lymph nodes, and tumors were harvested at 4-h, 8-h, 1-day, 3-day, 7-day, and 3-month post-treatment intervals for the analysis of frequencies, death, …

Increasing Pediatric Vaccination Rates Through Parental Education At A Federally Qualified Community Health Center: An Evidence-Based Quality Improvement Project, Dayna Dicola

Master's Theses and Capstones

Background: Childhood immunization rates for children aged 2 years and under at a community health center were assessed and determined to be below optimal levels. Immunizations protect against preventable diseases (Hill, 2023). The project assessed the microsystem to understand low immunization rates and to guide strategies for improvement.

Methods: The Plan-Do-Study-Act (PDSA) model was used. In the planning phase, key stakeholders were consulted to assess current rates and barriers contributing to immunization rates. The chosen intervention was placed simplified immunization schedules in pediatric exam rooms to educate parents and promote adherence.

Intervention: A visual guide detailing the recommended vaccination schedule …

Prevalence Of Resistant Escherichia Coli Isolated From Local Meats Sold In Tema Metropolis, Ghana, Frederick Adzitey, Innocent Allan Anachinaba, Charles Addo-Quaye Brown, Nurul Huda, Masmuniri Rambli

ASEAN Journal on Science and Technology for Development

Contamination of meat by Escherichia coli (E. coli) can take its source from the live animal or by cross contamination. The study determined the prevalence of resistance of E. coli isolated from locally produced meats in the Tema Metropolis. Beef (n=200), chicken (n=200) and pork (n=200) were randomly selected and evaluated for the presence of E. coli using the procedure in the Bacteriological Analytical Manual of USA-FDA. The disc diffusion method was used for antibiotic susceptibility test of E. coli (n=55) isolates. Locally produced beef (67%), chicken (41%) and pork (23%) were contaminated by E. coli. Escherichia coli isolates were …

Hpv Vaccination In Africa In The Covid-19 Era: A Cross-Sectional Survey Of Healthcare Providers' Knowledge, Training, And Recommendation Practices, Joel Fokom Domgue, Issimouha Dille, Sharon Kapambwe, Robert Yu, Freddy Gnangnon, Lameck Chinula, Gad Murenzi, Nomonde Mbatani, Mala Pande, Fatoumata Sidibe, Joseph Kamgno, Bangaly Traore, Hicham El Fazazi, Mamadou Diop, Pierre-Marie Tebeu, Mohenou Isidore Diomande, Fabrice Lecuru, Isaac Adewole, Marie Plante, Partha Basu, Jean-Marie Dangou, Sanjay Shete

Faculty, Staff and Student Publications

INTRODUCTION: Although the burden of cervical cancer in Africa is highest, HPV vaccination coverage remains alarmingly low in this region. Providers' knowledge and recommendation are key drivers of HPV vaccination uptake. Yet, evidence about providers' knowledge and recommendation practices about the HPV vaccine against a backdrop of emerging vaccine hesitancy fueled by the COVID-19 pandemic is lacking in Africa.

METHODS: A cross-sectional study was conducted in 2021-2022 among healthcare providers involved in cervical cancer prevention activities in Africa. They were invited to report prior training, the availability of the HPV vaccine in their practice, whether they recommended the HPV vaccine, …

Phospholipid Metabolic Adaptation Promotes Survival Of Idh2 Mutant Acute Myeloid Leukemia Cells, Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa

Faculty, Staff and Student Publications

Genetic mutations in the isocitrate dehydrogenase (IDH) gene that result in a pathological enzymatic activity to produce oncometabolite have been detected in acute myeloid leukemia (AML) patients. While specific inhibitors that target mutant IDH enzymes and normalize intracellular oncometabolite level have been developed, refractoriness and resistance has been reported. Since acquisition of pathological enzymatic activity is accompanied by the abrogation of the crucial WT IDH enzymatic activity in IDH mutant cells, aberrant metabolism in IDH mutant cells can potentially persist even after the normalization of intracellular oncometabolite level. Comparisons of isogenic AML cell lines with and without IDH2 gene mutations …