Digital Commons Network^™

An Exploration Of K-3 Teachers’ Beliefs, Attitudes, And Instructional Technology Use Pre-, During, And Post-Covid-19, Patience Mensah-Bonsu Aggrey

Electronic Theses and Dissertations

This qualitative multiple case study explores kindergarten to third-grade teachers use of instructional technology across three different periods: pre-COVID-19, during COVID-19, and post-COVID-19. This research investigates teachers’ attitudes, the use of technological tools by teachers, and the internal (second order) and external (first order) barriers that informed their use of instructional technology before and during the COVID-19 pandemic and continue to influence their use in the post-pandemic phase. Data were collected through questionnaires, interviews, and checklists from eight kindergarten third-grade teachers using a qualitative multiple case study approach. The findings suggest that there was a shift in teachers’ instructional technology …

Integrative Review: Opioid Crisis, Naloxone, And Overdose Mortality, Ja'nae Flowers, Melissa Gayle

Master's Projects

The opioid crisis is a public health challenge that includes widespread use and misuse of opioids, opioid addiction, and overdose deaths (Parkin et al., 2020). Opioids are a class of medications that include prescription analgesics as well as illicit (illegal) drugs. The opioid epidemic began between 1990 and 2000 as healthcare providers began prescribing opioids at alarming rates, which led to misuse, abuse, and addiction. The overall effects of opioid use disorder (OUD) include increased healthcare costs, socioeconomic challenges, and poor health outcomes. Cooperation among healthcare organizations, law enforcement, public policy, and community outreach is required to support patients with …

Discrimination, Sexual Orientation, And Alcohol Amongst Latine, Brian Juarez

Electronic Theses, Projects, and Dissertations

Existing research acknowledges the influence of discrimination on alcohol use, this study emphasizes the equally significant role of sexual orientation on alcohol use. Associations between these factors and alcohol consumption demonstrate the necessity for ongoing research to analyze their intricate relationships and subsequent health outcomes. This study highlights the crucial need for an in-depth exploration of discrimination as well as marginalized identities as contributing factors in alcohol consumption.

Using a quantitative approach to assess secondary data gathered from the National Alcohol Surveys (NAS), this paper underscores the importance of a comprehensive and timely approach to research the multifaceted impact of …

The Impact Of In Ovo Administration Of Probiotic Lactobacilli On The Gut Health And Immune Competence Of Broiler Chickens, Shreeya Sharma

All Theses

Due to the incomplete development of their immune system, newly hatched chicks are vulnerable to a wide range of pathogenic microorganisms, including enteric bacterial pathogens during the early stage of life. To boost their immune system during this critical period, numerous studies suggest early feeding, either in ovo or immediately post-hatch, of nutrients and immunomodulators such as prebiotics, probiotics, phytobiotics, Toll-like receptors (TLRs) ligands, vitamins and minerals. Probiotics, defined as live, non-pathogenic microorganisms that confer beneficial effects on the host, have been extensively studied for their effects on poultry health. Supplementation of probiotics to chickens has demonstrated a broad spectrum …

College Student’S Learning Experiences During Covid-19 Among Traditional And Post-Traditional Students Enrolled In Institutions Affiliated With The Appalachian College Association, Jo Anne Smith

Electronic Theses and Dissertations

The purpose of this study was to determine the differences in the learning experiences, feelings and emotions, level of study support, and online learning during the COVID-19 pandemic between traditional and post-traditional college students enrolled in an institution affiliated with the Appalachian College Association.

A two-group comparison research design using a web-based survey was used for the study. Using the College Student’s Learning Experiences during COVID-19 among Traditional and Post-Traditional Students Enrolled in Institutions Affiliated with the Appalachian College Association survey, the research questions were analyzed with a sample size of N = 58, traditional college student group and N=33, …

Overcoming The Barrier To The Clinical Application Of Naloxone: Application Of Drug Delivery Technologies, Akeemat O. Tijani

Electronic Theses and Dissertations

Opioid overdose crisis continues to demand innovative solutions for rapid and effective drug administration. Naloxone (NAL), a critical opioid antagonist, has been the primary treatment for reversing opioid-induced respiratory depression. However, its current delivery methods, such as intravenous and intranasal formulations, are limited by their invasive nature, short half-life, and the need for repeated dosing. This dissertation investigates advanced drug delivery technologies aimed at overcoming these challenges and enhancing the clinical utility of NAL.

This research focused on improving the transdermal and transnasal delivery of NAL using minimally invasive techniques. Various approaches were evaluated, including sonophoresis, microneedles, laser ablation, dermaplaning …

Service Provider Perceptions Of Systems Serving Individuals Experiencing Homelessness: A Needs Assessment And Strategic Plan In Johnson City, Tn, Opal Frye-Clark

Electronic Theses and Dissertations

This Integrated Learning Experience (ILE) investigates service providers' perceptions of Johnson City, Tennessee's homelessness services, aiming to inform a city-wide strategic plan for reduction. Employing a mixed-methods approach, the study gathered qualitative data through in-depth interviews with service providers in 2022 and quantitative data via a 2024 survey. The research focused on those directly involved in serving or significantly influencing the lives of individuals experiencing homelessness (IEH). Three key aims guided the investigation: (1) To analyze provider perspectives to identify community assets, opportunities, barriers, and unmet needs, informing a comprehensive needs assessment; (2) To refine these findings through SWOT analysis …

Elevated Levels Of Cd56+ T Cells, Cd16+ Cd56+ T Cells, And Cd56dim Nk Cells In Herpes Simplex Virus Type 1 Seropositive Healthy Individuals, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Meshari A. Alsuwat, Mustafa Halawi

Saudi Medical Journal

Objectives: To investigate the numbers of natural killer (NK) cells, CD56+ T-cells and CD56- T cells, and the levels ofCD16 in healthy individuals seropositive for herpes simplex virus Type 1 (HSV-1). Specifically, it seeks to measure the levels of these cells to learn about the possible immunological significance during HSV-1 seropositive status. Methods: This study employed a cross-sectional research design to examine the levels of CD56+ T-cells and CD16+ among individuals seropositive for herpes simplex virus type 1 (HSV-1) in Taif city. A total of 112 participants were enrolled, with HSV-1 serostatus determined via ELISA, and cellular evaluation conducted using …

Rising Epidemiological Trends In Prevalence And Mortality Of Mpox: Global Insights And Analysis, Muhammad Os. Meo, Muhammad Zs. Meo, Isra M. Khan, Muhammad As. Butt, Adnan M. Usmani, Sultan A. Meo

Saudi Medical Journal

Objectives: To explore the global epidemiological trends in the prevalence and mortality due to mpox in various regions worldwide. Methods: In this cross-sectional study the data about mpox outbreak were recorded by the “World Health Organization, Centers for Disease Control and Prevention, and GSAID” from August 2023 to August 2024, analyzing the epidemiological trends from different countries worldwide. Results: The total number of mpox cases has reached 99,518 (95,196 cases from 115 countries that have not historically reported mpox; and 4,322 cases from 07 states that have traditionally reported mpox), from a total of 122 countries. The top 10 countries …

Comparing Tele-Pharmacy And Standard Clinic Follow-Up For Newly Initiated Warfarin Anticoagulation Therapy: A Retrospective Study, Sumaiah J. Alarfaj, Sara Alsulami, Ebtehaj Alashjaey, Reema Albulayhi, Faisal Alqarni, Abeer Alharbi

Saudi Medical Journal

ABSTRACT Objectives: To compare the effectiveness of providing telepharmacy anticoagulation to on-site clinics in achieving optimal outcomes for patients newly starting warfarin. Methods: This single-center retrospective cohort study included adult patients who started warfarin for the first time and were monitored by clinical pharmacists either on-site or via telepharmacy anticoagulation clinics between January 2017 and March 2024. The primary outcome is to compare the time in therapeutic range (TTR) between the 2 groups. The secondary outcome is the occurrence of anticoagulation therapy–related complications. Results: We included 191 patients, with 77 in the telepharmacy group and 114 in the on-site group. …

Assessing The Accuracy And Efficiency Of Chat Gpt-4 Omni (Gpt-4o) In Biomedical Statistics: Comparative Study With Traditional Tools, Anusha S. Meo, Narmeen Shaikh, Sultan A. Meo

Saudi Medical Journal

ABSTRACT Objectives: To assess the accuracy of ChatGPT-4 Omni (GPT-4o) in biomedical statistics. The recent novel inauguration of Artificial Intelligence ChatGPT-Omni (GPT-4o), has emerged with the potential to analyze sophisticated and extensive data sets, challenging the expertise of statisticians using traditional statistical tools for data analysis. Methods: This study was performed in the Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia, in May 2024. Three datasets in a raw Excel file format were imported onto Statistical Package for the Social Sciences (SPSS) version 29 for data analysis. Based on this analysis, a script of 9 questions …

Beyond Charity: The Development Of The Mission Of The Daughters Of Charity In Sub-Saharan Africa, Theresa Eke

Vincentian Studies

Theresa Eke recounts the history of the Daughters of Charity’s service in Africa and explains the evolution of their approach to poverty alleviation there. The Daughters learned the importance of knowing the cultures and languages of those they served. At first, they addressed poverty with donations of material goods, but later they empowered the poor, teaching them skills and helping them establish farms and businesses, particularly through helping them to purchase equipment. They learned to listen to what the poor themselves said would help them. They supported high school and university education, especially for women and girls. The Daughters also …

Lack Of Inflammatory Response In Mouse Embryonic Cells To Listeria Infection, Damilola Oyebode

Master's Theses

Approximately 1 in 5 pregnancies in the United States results in miscarriage, with a significant percentage of these losses attributed to failed implantation due to immunological challenges encountered by the early embryo. Recent research has shown that key cell types within mouse blastocysts, including embryonic stem cells (ESCs) and trophoblast stem cells (TSCs), exhibit remarkable resilience against the cytotoxic effects associated with viral infections and embryotoxic cytokines, such as TNFα and IFNγ, both of which are known to hinder blastocyst development. However, the immune properties of the preimplantation stage embryo, specifically the blastocyst, remain poorly understood. Using mouse cell model, …

Sexual Orientation, Gender Identity And Virologic Failure Among People With Hiv: A Cohort Study In All Of Us Research Program, Fanghui Shi, Ruilie Cai, Buwei He, Xiaoming Li Ph.D., Xueying Yang Ph.D., Sharon Weissman, Bankole Olatosi Ph.D., Jiajia Zhang Ph.D.

Faculty Publications

Background: Sexual and gender minorities (SGMs) are at higher risk of HIV incidence compared to their heterosexual cisgender counterparts. Despite the high HIV disease burden among SGMs, there was limited data on whether they are at higher risk of virologic failure, which may lead to potential disease progression and increased transmission risk. The All of Us (AoU) Research Program, a national community-engaged program aiming to improve health and facilitate health equity in the United States by partnering with one million participants, provides a promising resource for identifying a diverse and large volunteer TGD cohort. Leveraging various data sources available through …

Ten-Year Review Of St-Segment Elevation Myocardial Infarction (Stemi) In Tanzania: A Single Center Retrospective Review, Nadeem Kassam, Mohamed Varwani, Mzee Ngunga, Jeilan Mohamed, Mangaro Mabusi, James Orwa, Salim Surani, Robert Mvungi, Nasiruddin Jamal

Internal Medicine, East Africa

Introduction: Ischemic Heart Disease (IHD) is an emerging epidemic in sub-Saharan Africa (SSA). Although the true burden may be underreported in the African continent, it still remains one of the leading causes of death among adults aged above 60 years. ST-Segment Elevation Myocardial Infarction (STEMI) is a clinically time-sensitive fatal sequela of IHD with timely reperfusion by primary Percutaneous Coronary Intervention (PCI) being the gold standard of care. There has been steady progress in coronary care services in Tanzania, alongside a rise in IHD-related risk factors. However, data on this is limited. This study aimed to examine trends in …

Navigating Physical Activity Promotion And Policy In The Post-Covid-19-Pandemic Era, Justin Richards, Katja Siefken, Michael Pratt, Adrian Bauman, Juliana Mejía-Grueso, Catherine B Woods, Wanda Wendel-Vos, Erica Hinckson, Deborah Salvo, Pedro C Hallal, Andrea Ramírez Varela

Faculty, Staff and Student Publications

Background: There is limited evidence on the priorities and opportunities associated with promoting population physical activity (PA) participation for the post-COVID-19-pandemic future.

Purpose: This study assessed government-led PA promotion efforts before and during the COVID-19 pandemic, along with post-COVID-19-pandemic priorities and recommendations.

Methods: Two separate cross-sectional surveys conducted in 2023. Survey 1 was targeted at the Global Observatory for Physical Activity (GoPA!) Country Contacts. Survey 2 also included key international informants representing influential stakeholders in PA policy implementation.

Results: There were 68 respondents to Survey 1, collectively representing 61 countries. An additional 37 people, including representatives from 14 key international …

The Role Of Lifr Signaling In Innate Immunity, Laura Kahn Serrudo

Dissertations and Theses (Open Access)

The localized signals that bone marrow (BM) hematopoietic stem cells (HSCs) and immune cells receive are critical in regulating their responses in the steady state and inflammation. Monocytes are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory cytokines, and differentiation into monocyte-derived dendritic cells (MoDCs), which are required for efficient pathogen eradication.

Here, we uncovered LIFR (leukemia inhibitory factor receptor) restrains low-grade chronic inflammation in …

Oncolytic Viruses Enhance Long-Term Nk Cell Anti-Tumor Cytotoxicity Through Ap-1 And Irf Pathway Activation, Xin Ru Jiang

Dissertations and Theses (Open Access)

Natural killer (NK) cell therapeutics have emerged as a promising strategy in adoptive cellular therapy. While genetic modifications of NK cells can enhance their antitumor activity, modulating the tumor to augment NK cell recognition and function remains underexplored. In this study, we investigated the combination of NK cells with oncolytic viruses to treat solid tumors, specifically pancreatic ductal adenocarcinoma and glioblastoma. We demonstrated that infecting tumor cells with the oncolytic adenovirus Delta-24-RGD significantly increases their susceptibility to NK cell cytotoxicity, driven by a hyperactivated NK cell phenotype characterized by elevated expression of activating receptors and cytotoxicity markers. In a patient-derived …

Local Or Systemic Antibody-Targeted Sting Activation Drives Pro- Inflammatory Stromal Metabolic Changes And Downregulates C-Myc Oncoprotein, Akash Boda

Dissertations and Theses (Open Access)

The past decade has witnessed remarkable advances in the field of cancer immunotherapy. Immune checkpoint blockade (ICB) has emerged as a cornerstone, achieving long-lasting tumor regression in several types of cancer. However, its effectiveness is often limited, particularly in certain tumor types. Immunologically "cold" tumors, such as pancreatic ductal adenocarcinoma (PDAC), remain clinically unresponsive to ICB, presenting a significant challenge in oncology. Amidst these challenges, the stimulation of the STING pathway via small molecule synthetic agonists has surfaced as a promising strategy. Acting as an in-situ vaccine, STING activation has the potential to transform the immune landscape of cold tumors …

The Role Of Ganglioside Gd2 And Gd3 Synthase (St8sia1) In The Regulation Of Immune Suppression In Breast Cancer, Bolutyfe Oderinde

Dissertations and Theses (Open Access)

Gangliosides are acidic glycosphingolipids involved in cell adhesion, proliferation, and modulation of signal transduction pathways. It has been reported that tumor-shed gangliosides influence the activity of immune cells including macrophages, NK cells, and T cells. GD3 synthase (GD3S) is the key enzyme that regulates the biosynthesis of the b and c series gangliosides, particularly GD3 and GD2, and studies have shown that GD3S is upregulated in most tumors and plays a role in tumor progression. Similarly, we have previously found GD3S to be significantly upregulated in GD2+ breast cancer stem cells (BCSC) compared to GD2- cells, and the knockdown of …

Covid-19 Risk Assessment Among Vulnerable Small Business Owners In El Paso County, Texas, Sadie H Conway, Denise Vasquez, Kristina D Mena, Louis D Brown, Soyoung Kwon, Janelle Rios

Faculty, Staff and Student Publications

Background: Our objective was to deliver actionable, worksite-specific COVID-19 risk assessments and mitigation strategies tailored to vulnerable workers in one of the highest-risk areas in the US.

Methods: Four trained, bilingual (English/Spanish) community health workers (CHWs) recruited small businesses (ie, ≤20 employees) across various industries and executed novel on-site infectious disease risk assessment surveys of at least one employer and one employee.

Results: Of 102 participating businesses (95% Hispanic-owned), 96% were characterized as "high risk" or "very high risk" for disease transmission. All businesses reported implementing at least one practice to reduce disease transmission; however, almost half of businesses lacked …

Effectiveness Of Enhanced Care For Treatment Of Acute Or Persistent Diarrhea In Malnourished Children Aged 0 Months To 10 Years: A Systematic Review, Ridwa Alam, Khadija Vadsaria, Ahmad Khan, Uswa Jiwani, Aqsa Ishaq, Anmol Minaz, Ashraf Sharif, Jai K. Das, Sajid Bashir Soofi, Shabina Ariff

Centre of Excellence in Women and Child Health

Background: Diarrhea poses a significant public health challenge, particularly affecting children under five. The link between malnutrition and diarrhea is well established, with diarrhea being a primary cause of malnutrition in young children and malnutrition exacerbating the severity of diarrhea. While the World Health Organization (WHO) recommends a comprehensive approach to both diarrhea and malnutrition management, including oral rehydration, continuous feeding, zinc supplementation, and antibiotics for specific strains, it does not adequately address the complex needs of malnourished children with diarrhea who may benefit from enhanced care in the form of follow-up and monitoring beyond initial treatment. We aimed to …

Journey Of Decisions: Understanding Parental Perspectives On Vaccine Hesitancy And Decision-Making Approaches In Childhood Vaccinations, Carlene Joy Brown

Dissertations

The purpose of this study is to gain an understanding of parental attitudes toward childhood vaccinations and decision-making styles. Overall, this study worked to comprehensively examine the factors influencing vaccine hesitancy among parents of children under 18 utilizing quantitative and qualitative methodologies and conducting qualitative analytic comparisons to enhance understanding for future research practices.

The study’s objective in the first phase was to quantitatively assess whether decision-making styles predict vaccine hesitancy, considering demographic factors. The contextual research question guiding this phase was, “Do general decision-making styles predict vaccine hesitancy controlling for age, gender, level of education, employment status, marital status, …

Exploring Mechanisms Of Chemical Resistance In Xanthomonas Arboricola Pv. Pruni And Strategies To Mitigate Resistance And Improve Disease Control, Milan Panth

All Dissertations

Xanthomonas arboricola pv. pruni (XAP) is a phytopathogenic bacterium that causes bacterial spot of peach. It causes spotted lesions on leaves and fruit, leading to early defoliation and unmarketable fruit, respectively. The pathogen can overwinter in twig cankers, which serve as the primary initial inoculum source for the next season’s leaf and fruitlet infection. The current disease management practice mainly relies on routine application of chemical bactericides containing copper or oxytetracycline (OTC) in the growing season. However, disease incidence can still be high despite chemical control measures in warm, rainy seasons.

Frequent applications of copper and OTC in United …

Emerging Agency In Border Communities During Pandemics, William Ordeman

All Dissertations

“Emerging Agency in Border Communities During Pandemics” uncovers the complex natural and social histories of two Texas border counties, El Paso and Hidalgo, to explain how these counties became highly susceptible to the COVID-19 outbreak in 2020. This work argues that humans engaging with natural resources throughout history created a rhetoric of exploitation and social hierarchy along the Texas/Mexico border. Rhetoric from Spanish and Anglo colonists coupled with environmental phenomena across time displaced Latinx/e bodies living in these counties into precarious communities called colonias, and the presence of these colonias made each county highly susceptible to disease outbreak. I …

Promoting Adolescent Mental And Physical Health: Initiatives Focused On Connecting Public Health And Social Services To The Health Sector In Nebraska, Theresa Nguyen

Capstone Experience: Master of Public Health

This capstone focuses on the second recommendation of improving access to comprehensive, coordinated health services from the National Academies of Sciences, Engineering, and Medicine report The Promise of Adolescence: Realizing Opportunity for All Youth (2019). This proposal uses secondary data from the research project, Moving Evidence-Based Recommendations to Practice to Strengthen the Health Care System in Nebraska. Key stakeholders (n=28) were interviewed from the health care, public health, social services, and policy sectors. Each subject was asked to participate in a semi-structured interview by a trained interviewer. The interview was 1 hour long and conducted via phone call or Zoom. …

The Informal, Non-Prescribed Use Of Antiretroviral Medications For Prep Among A National Us-Based Sample Of Gay, Bisexual, And Other Men Who Have Sex With Men: A Cross-Sectional Study, Mance E. Buttram, Matthew S. Ellis, Krishen D. Samuel, Matthew Hayhurst

Health, Human Performance and Recreation Faculty Publications and Presentations

This brief report presents findings on informal, non-prescribed PrEP use among an online sample of gay, bisexual and other men who have sex with men (n = 196). Mean age was 33.4. Participants were Hispanic (13.3%), African American (15.8%), white (63.8%), and other race/ethnicity (6.6%). Informal PrEP users (11%) more frequently reported past year sexually transmitted infections (p < 0.001), group sex (p < 0.001), sex in public (p < 0.01), transactional sex (p < 0.001), ever receiving a formal PrEP prescription (p < 0.05), and ease of finding diverted HIV medications on gay dating/sex apps (p < 0.05). Formal PrEP uptake should be encouraged to mitigate potential negative consequences of informal use.

Maternal Adverse Childhood Experiences And Non-Live Births, Mudasir Mustafa

All Graduate Theses and Dissertations, Fall 2023 to Present

Around 62 percent of adults in the United States have endured at least one type of Adverse Childhood Experience (ACE), and 25 percent of women reported experiencing three or more ACEs in their lifetime. This study explored whether maternal exposure to ACEs was associated with pregnancy loss or abortion, utilizing the National Longitudinal Study of Adolescent to Adult Health (known as Add Health) to explore this association. I found that cumulative ACEs, assessed through either the conventional ACE scale (reflecting 10 types of ACEs) or the extended ACE scale (reflecting 14 types of ACEs), are associated with a higher likelihood …

Immune Variation Across Different Contexts In Non-Model Systems, Kwanho Claudia Ki

All Graduate Theses and Dissertations, Fall 2023 to Present

The immune system is important to an animal’s survival against disease-causing agents and physical injuries. Accordingly, many resources are required to maintain and activate the immune system (such as energy). However, as these resources also need to be shared with other important systems of the body, the portion of resources that can be allotted to the immune system is variable. Thus, many different factors may alter how well the immune system operates. My dissertation sought to understand what sorts of factors can lead to changes in the immune system. Reptiles are known to have a very robust immune system. Therefore, …

Designing Technology-Enriched Learning Environments: The Effects Of An Agent-Based Computer Model On Biology Students' Understanding Of The Covid-19 Pandemic And The Nature Of Models In Science, April Sullivan

All Graduate Theses and Dissertations, Fall 2023 to Present

Science education researchers have called for increased attention to the science practice of modeling to engage students in authentic scientific inquiry. A major challenge to integrating the modeling practice into science instruction is that students tend to conceptualize models as static end-products of research rather than generative tools for theory-building. Engaging students in using computer models, specifically agent-based computer models (ABMs), to explain and predict scientific phenomena could improve students' understanding of models in science. In this design-based research project I investigate the effects of an ABM-supported learning environment on high-school biology students' understanding of the COVID-19 pandemic and the …