Digital Commons Network^™

Changes In Revenues Associated With Antimicrobial Reimbursement Reforms In Germany, Matt Mcenany, Kevin Outterson

Faculty Scholarship

Policy declarations from the G7 and other high-level meetings call for increased incentives for antimicrobial research and development (R&D). Governments fund push incentives like CARB-X and GARDP, and G7 countries are now designing pull incentives—financial rewards given to manufacturers post-market authorization that are intended to encourage the creation and introduction of novel antimicrobials. Germany has declared previously at the G7 that it has developed a pull incentive that will increase revenues from sales of important new antimicrobials, principally by exempting them from some aspects of health technology benefit assessments and reference pricing, which should result in higher prices. This policy …

Mental Models Of Translational Scientists, Rasnia Tabpla, Antonie J. Jetter

Engineering and Technology Management Faculty Publications and Presentations

Translational science aims to bridge the gap between scientific discoveries and practical application yet faces challenges in achieving high success rates. This study examines the effective engagement of translational scientists, who play a key role in the translation process. It uses Fuzzy Cognitive Maps (FCMs) to analyze the scientists' mental models and identify common concepts related to success factors, such as ability, resources, opportunity, and entrepreneurial competencies. It then compares the mental models of the scientists and finds that mental models exhibit similarities, yet variations exist such as density and connectedness. Scenario analysis with FCM is then used to identify …

Concurrent Varicella-Zoster Virus Reactivation And Recurrent Herpes Simplex Virus Infection In The C2 Dermatome With Varicella-Zoster Virus Encephalitis: A Case Report And Review Of The Literature., Morgan A Hatlovic, Madison Anzelc, Matthew Franklin

Ambulatory and Primary Care Articles

Herpes simplex virus (HSV) and varicella-zoster virus (VZV) are common viruses that are present in the general population. However, it is uncommon for both viruses to coincide at the same time and location. These viruses infect the nervous system to establish latency and have been associated with neurological disorders. We discuss a case of co-occurring VZV reactivation and recurrent HSV infection with subsequent VZV encephalitis following an insult to the neurologic system.

Preeclampsia In The Context Of Covid-19: Mechanisms, Pathophysiology, And Clinical Outcomes, Guilherme M Nobrega, Brittany R Jones, Indira U Mysorekar, Maria Laura Costa

Center on Aging Staff Publications

The emergence of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to the global COVID-19 pandemic, significantly impacting the health of pregnant women. Obstetric populations, already vulnerable, face increased morbidity and mortality related to COVID-19, aggravated by preexisting comorbidities. Recent studies have shed light on the potential correlation between COVID-19 and preeclampsia (PE), a leading cause of maternal and perinatal morbidity worldwide, emphasizing the significance of exploring the relationship between these two conditions. Here, we review the pathophysiological similarities that PE shares with COVID-19, with a particular focus on severe COVID-19 cases and in PE-like syndrome cases related with …

Analysis Of Malarial Impact: Understanding Disease Transmission, Epidemiology, And Effects On Fetal Life, Josey Sumpter

Graduate Student Dissertations, Theses, Capstones, and Portfolios

Malaria is a significant public health problem which mainly affects malaria endemic regions, such as parts of Africa, South America, and Western Asia. However, all hot and humid environments are susceptible to spread leading to a global scale. Malaria affects an estimated 200 million people each year, with about 600,000 cases resulting in death. Malaria is passed through the bites of infected female anopheles mosquitos, with one of the six Plasmodium genus parasites that are malarial causing. Once the parasite enters the blood stream it infects erythrocytes which can then spread throughout the entire body. Disease is often characterized by …

Clinical Features And Outcomes Of Pediatric And Adult Patients Hospitalized For Coronavirus Disease 2019: A Comparison Across Age Strata, Grace X Li, Komal Gopchandani, Noah Brazer, Ashley Tippett, Chris Choi, Hui-Mien Hsiao, Miriam Oseguera, Abiodun Foresythe, Sanchita Bhattacharya, Venice Servellita, Alicia Sotomayor Gonzalez, Jennifer K Spinler, Mark D Gonzalez, Dalia Gulick, Colleen Kraft, Vyjayanti Kasinathan, Yun F Wayne Wang, Jennifer Dien Bard, Pei Ying Chen, Jessica Flores-Vazquez, Audrey R Odom John, Paul J Planet, Sridevi Devaraj, Ananth V Annapragada, Ruth Ann Luna, Charles Y Chiu, Christina A Rostad

Faculty, Staff and Students Publications

BACKGROUND: Coronavirus disease 2019 (COVID-19) continues to cause hospitalizations and severe disease in children and adults.

METHODS: This study compared the risk factors, symptoms, and outcomes of children and adults hospitalized for COVID-19 from March 2020 to May 2023 across age strata at 5 US sites participating in the Predicting Viral-Associated Inflammatory Disease Severity in Children with Laboratory Diagnostics and Artificial Intelligence consortium. Eligible patients had an upper respiratory swab that tested positive for severe acute respiratory syndrome coronavirus 2 by nucleic acid amplification. Adjusted odds ratios (aOR) of clinical outcomes were determined for children versus adults, for pediatric age …

Encompassing ‘Himdag’ (Indigenous Way Of Life) To Address Cardiometabolic Disease In American Indian And Alaska Native Communities Through Research, Policy And Action, Heather Medicine Bear

Theses and Dissertations

Cardiometabolic diseases (CMD), encompassing conditions such as cardiovascular disease, diabetes, kidney disease and non-alcoholic fatty liver disease, present a significant health burden within American Indian and Alaska Native (AI/AN) communities. This dissertation, through the culmination of three products, including a scoping review, policy brief and strategic planning toolkit, seeks to understand and address CMD in tribal communities through an Indigenous lens. Product #1, Interventions for Cardiometabolic Health in American Indian and Alaska Native Communities: A Scoping Review, entails a thorough review of implemented CMD interventions targeting AI/AN communities to understand programmatic, clinical, and community-based prevention strategies. By synthesizing available evidence, …

Eliciting Clinician Perspectives On Asymptomatic Bacteriuria To Identify Targets For Antimicrobial Stewardship Education And Decision Support, Michael J Durkin, Viktoria Schmitz, Kevin Hsueh, Katheryn Ney, Mary C Politi

2020-Current year OA Pubs

BACKGROUND: The aim of this study was to elicit clinicians' perspectives to help reduce antibiotic prescribing for asymptomatic bacteriuria and improve a patient-centered educational brochure for older adults with urinary tract infections or asymptomatic bacteriuria.

METHODS: Between October 2023 and April 2024, we conducted semi-structured qualitative interviews of clinicians who treat patients aged ≥65 years for urinary tract infections or bacteria in the urine, at infectious disease clinics, community senior living facilities, memory care clinics, and general practice. We developed an interview guide based on a behavior change framework and thematically analyzed written transcripts of audio-recorded interviews using inductive and …

Population Pharmacokinetic Modelling And Simulation Of Tranexamic Acid In Adult Trauma Patients, Gideon Stitt, Philip C Spinella, Grant V Bochicchio, Ian Roberts, Kevin J Downes, Athena F Zuppa

2020-Current year OA Pubs

AIMS: The aim of this study is to describe the disposition of tranexamic acid (TXA) in adult trauma patients and derive a dosing regimen that optimizes exposure based on a predefined exposure target.

METHODS: We performed a population pharmacokinetic (popPK) analysis of participants enrolled in the Tranexamic Acid Mechanisms and Pharmacokinetics in Traumatic Injury (TAMPITI) trial (≥18 years with traumatic injury, given ≥1 blood product and/or requiring immediate transfer to the operating room) who were randomized to a single dose of either 2 or 4 g of TXA ≤2 h from time of injury. PopPK analysis was conducted using nonlinear …

Opportunities To Improve Antibiotic Prescribing For Adults With Acute Sinusitis, United States, 2016–2020, Axel A Vazquez Deida, Destani J Bizune, Christine Kim, John M Sahrmann, Guillermo V Sanchez, Adam L Hersh, Anne M Butler, Lauri A Hicks, Sarah Kabbani

2020-Current year OA Pubs

BACKGROUND: Better understanding differences associated with antibiotic prescribing for acute sinusitis can help inform antibiotic stewardship strategies. We characterized antibiotic prescribing patterns for acute sinusitis among commercially insured adults and explored differences by patient- and prescriber-level factors.

METHODS: Outpatient encounters among adults aged 18 to 64 years diagnosed with sinusitis between 2016 and 2020 were identified by national administrative claims data. We classified antibiotic agents-first-line (amoxicillin-clavulanate or amoxicillin) and second-line (doxycycline, levofloxacin, or moxifloxacin)-and ≤7-day durations as guideline concordant based on clinical practice guidelines. Modified Poisson regression was used to examine the association between patient- and prescriber-level factors and guideline-concordant …

Plasma Galectin-9 Relates To Cognitive Performance And Inflammation Among Adolescents With Vertically Acquired Hiv, Preeti Moar, Soe Mar, Et Al.

2020-Current year OA Pubs

OBJECTIVE: Adolescents with perinatally acquired HIV (AWH) are at an increased risk of poor cognitive development yet the underlying mechanisms remain unclear. Circulating galectin-9 (Gal-9) has been associated with increased inflammation and multimorbidity in adults with HIV despite antiretroviral therapy (ART); however, the relationship between Gal-9 in AWH and cognition remain unexplored.

DESIGN: A cross-sectional study of two independent age-matched cohorts from India [AWH on ART ( n  = 15), ART-naive ( n  = 15), and adolescents without HIV (AWOH; n  = 10)] and Myanmar [AWH on ART ( n  = 54) and AWOH ( n  = 22)] were studied. …

Ai-Driven Deep Learning Techniques In Protein Structure Prediction, Lingtao Chen, Qiaomu Li, Kazi Fahim Ahmad Nasif, Ying Xie, Bobin Deng, Shuteng Niu, Seyedamin Pouriyeh, Zhiyu Dai, Jiawei Chen, Chloe Yixin Xie

2020-Current year OA Pubs

Protein structure prediction is important for understanding their function and behavior. This review study presents a comprehensive review of the computational models used in predicting protein structure. It covers the progression from established protein modeling to state-of-the-art artificial intelligence (AI) frameworks. The paper will start with a brief introduction to protein structures, protein modeling, and AI. The section on established protein modeling will discuss homology modeling, ab initio modeling, and threading. The next section is deep learning-based models. It introduces some state-of-the-art AI models, such as AlphaFold (AlphaFold, AlphaFold2, AlphaFold3), RoseTTAFold, ProteinBERT, etc. This section also discusses how AI techniques …

A Case Of Herpes Zoster In An Immunocompetent 19-Year-Old Female, Martin Nguyen, Jennifer Read, Emma Filary, Aaron Mcguffin

Marshall Journal of Medicine

This case report describes the unusual presentation of herpes zoster in a fully vaccinated teenage patient and highlights management considerations. The patient is a 19-year-old female who presented with pain in her left lower back, side, and upper thigh for approximately 3 days, which was then followed by the eruption of a vesicular rash along the L2 dermatome consistent with herpes zoster. Herpes zoster is predominantly observed only in elderly and immunocompromised individuals, primarily due to the widespread use of the varicella-zoster virus vaccine for children since 1995, when it became part of the routine immunization schedule. However, this case …

Exploring The Dark And Gothic: An Analysis Of Edgar Allan Poe And Nathaniel Hawthorne’S Gothic Elements In American Literature, Alejandra Serna

Theses and Dissertations

This paper examines the significant contributions of Edgar Allan Poe and Nathaniel Hawthorne to the development of American Gothic literature. Poe’s stories “The Tell-Tale Heart” and “The Black Cat” are renowned for their psychological elements and exploration of the human psyche, while Hawthorne’s “The Birthmark” questions the nature of evil as a universal human experience. By examining the ways in which these authors engage with themes of mental disorders, symbolism, and science versus nature, this thesis explores how such work by Poe and Hawthorne play in shaping the readers' understanding of the darker elements of American Gothic literature and its …

How Housing Insecurity And Welfare Systems Retraumatize Women In Southern California, Yesika Menera

McNair Summer Research Program

Studies show that individuals experiencing homelessness and housing insecurity also experience trauma and mental illnesses. Despite this evidence, many resources provided through state welfare services seldom allocate sufficient funds and personnel to help address mental health. This study investigates the relationship between housing insecurity and trauma for adult women who have tried to access assistance throughout Southern California. To do this, I conducted in-depth interviews and DSM-5 questionnaires with twenty-six women during the summer of 2023 and 2024 via Zoom. My findings show that adult women who have experienced homelessness and housing insecurity in Southern California were more susceptible to …

Analisis Faktor Risiko Kejadian Kematian Akibat Penyakit Kardiovaskular Jemaah Haji Indonesia Tahun 2023, Muhammad Aulia Rahman, Martya Rahmaniati, Raissa Lingga Angesti

Jurnal Biostatistik, Kependudukan, dan Informatika Kesehatan

Ibadah haji adalah ibadah yang dilakukan oleh umat muslim di seluruh dunia pada waktu dan tempat yang sudah ditentukan, yang pada tahun 2023 lalu dilakukan oleh 1.845.045 jiwa dari seluruh dunia. Sebagian besar dari kegiatan ibadah haji merupakan kegiatan fisik, ditambah stresor eksternal seperti cuaca, udara yang panas dan teriknya matahari, membuat faktor kesehatan menjadi bagian penting dalam menunjang kelancaran seluruh proses ibadah haji, adapun kriteria sehat tersebut ditentukan berdasarkan istithaah kesehatan jemaah haji. Kematian jemaah haji di tahun 2023 mengalami peningkatan yang cukup signifikan dari tahun-tahun sebelumnya, angkanya mencapai 798 jiwa, dan 42%nya merupakan kematian akibat penyakit kardiovaskular. Oleh …

New Approach To Mapping Regional Vulnerability In Controlling Tuberculosis Disease In Indonesia, Maria Holly Herawati, Asep Hermawan, Dasuki Dasuki, Hadi Supratikta, Al Asyary, M Rokhis Khomarudin, Muhammad Priyatna, Raflizar Raflizar, Kristina Kristina, Noer Endah Pracoyo, Dina Bisara, Cahya Tri Purnami, Mentari Nur Farida Suteja, Yusrial Bachtiar, Noor Edi Widya Sukoco, Doni Lasut

Kesmas

Tuberculosis (TB) in Indonesia is still a health problem. The TB prevalence in Indonesia ranks second in the world after India in 2023. Regional factors, inadequate healthcare facilities, and limited resources (financial, human, and infrastructure) are challenges requiring innovation to help the government control TB. TB eradication efforts need to be made with a comprehensive and effective approach. One method used is to look at the vast territory of Indonesia, therefore, mapping the TB disease vulnerability is a highly recommended method. The use of a Geographic Information System is expected to help map the TB vulnerability areas in Indonesia. Given …

Adaptative Survival Of Aspergillus Fumigatus To Echinocandins Arises From Cell Wall Remodeling Beyond Β−1,3-Glucan Synthesis Inhibition, Malitha C. Dickwella Widanage, Isha Gautam, Daipayan Sarkar, Frederic Mentink-Vigier, Josh V. Vermaas, Shi You Ding, Andrew S. Lipton, Thierry Fontaine, Jean Paul Latgé, Ping Wang, Tuo Wang

School of Graduate Studies Faculty Publications

Antifungal echinocandins inhibit the biosynthesis of β−1,3-glucan, a major and essential polysaccharide component of the fungal cell wall. However, the efficacy of echinocandins against the pathogen Aspergillus fumigatus is limited. Here, we use solid-state nuclear magnetic resonance (ssNMR) and other techniques to show that echinocandins induce dynamic changes in the assembly of mobile and rigid polymers within the A. fumigatus cell wall. The reduction of β−1,3-glucan induced by echinocandins is accompanied by a concurrent increase in levels of chitin, chitosan, and highly polymorphic α−1,3-glucans, whose physical association with chitin maintains cell wall integrity and modulates water permeability. The rearrangement of …

Bibliometric Analysis Of Research Trends And Novelties For Pneumonia In Children, Ariyani Lutfitasari, Fitriani Nur Damayanti, Budi Santosa, Lia Mulyanti, Umi Khasanah

Jurnal Keperawatan Indonesia

Pneumonia is the leading cause of death among children globally, with most cases occurring in low- and middle-income nations. Pneumonia in children has been thoroughly researched in numerous countries throughout the world. However, no research performed bibliometric analyses of pneumonia in children. This study aims to use a biometric analysis to determine trends in the number of publications, the number of citations, network visualization, overlay visualization, and density visualization concerning the issue of pneumonia in children. This research method employs a systematic review with stages adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart. The highest …

Why Did They Fail? Investigating The Eight Invalid Dimensions Of Patient Safety Culture: Mixed Method Research, Felicia Setiawan, Ferdi Antonio

Jurnal Keperawatan Indonesia

Resistance to adopting patient safety culture practices or technologies can hinder improvements in patient safety. This study contributes to enhancing the understanding of patient safety culture (PSC) assessment by identifying the specific factors that render some PSC dimensions invalid and offering actionable recommendations for improvement in healthcare settings. Primary data were gathered using a mixed method of explanatory sequential design, with quantitative data collection and analysis followed by qualitative data collection and analysis. The study was conducted in the leading Private Hospital XYZ, one of the private hospital groups internationally accredited with Joint Commission International with a 110-patient bed capacity. …

Adaptation Of The Protein Misfolding Cyclic Amplification (Pmca) Technique For The Screening Of Anti-Prion Compounds, Katherine Do, Rebeca Benavente, Celso S G Catumbela, Uffaf Khan, Carlos Kramm, Claudio Soto, Rodrigo Morales

Faculty, Staff and Student Publications

Prion diseases result from the misfolding of the physiological prion protein (PrPC) to a pathogenic conformation (PrPSc). Compelling evidence indicates that prevention and/or reduction of PrPSc replication are promising therapeutic strategies against prion diseases. However, the existence of different PrPSc conformations (or strains) associated with disease represents a major problem when identifying anti-prion compounds. Efforts to identify strain-specific anti-prion molecules are limited by the lack of biologically relevant high-throughput screening platforms to interrogate compound libraries. Here, we describe adaptations to the protein misfolding cyclic amplification (PMCA) technology (able to faithfully replicate PrPSc strains) that increase its throughput to facilitate the …

Economic Loss Of Leptospirosis: Is It Still Appropriate To Be Tropical Neglected Zoonosis Disease?, Wahyu Pudji Nugraheni, Sinta Dewi Lestyoningrum, Ristiyanto Ristiyanto, Wahyu Gito Putro, Indah Pawitaningtyas, Syarifah Nuraini, Linta Meyla Putri, Debri Rizki Faisal, Adhista Eka Noveyani, Muhammad Agus Mikrajab

Kesmas

Leptospirosis is a tropical endemic disease that can reduce the productivity of sufferers. However, research on economic and productivity losses due to leptospirosis is rare. This study aimed to determine economic and productivity losses due to leptospirosis in the Banyumas District, Indonesia, as an endemic area. This study used a cross-sectional design and quantitative methods conducted in October 2022. Secondary data of medical records and billing information from 73 inpatients receiving treatment at a Public Hospital in the Banyumas District from February 2021 to September 2022 obtained from the hospital’s archives were used. This study examined the actual costs (direct …

Data Mining Analysis With Orange In The Development Of Tuberculosis Among Diabetes Mellitus Patients, Malahayati Rusli Bintang, Adang Bachtiar, Cicilya Candi

Kesmas

Prevention and treatment of diabetes will have a positive influence on tuberculosis (TB) since people may get TB because they have diabetes mellitus (DM). Recording and reporting through the TB Information System are not run optimally because of many factors. The information system must be strengthened to be used by private health facilities. This study used secondary data from the 2013 and 2018 Indonesian Basic Health Research (IBHR). The data was analyzed univariately and analyzed further using Orange Data Mining Tools to test the screening tool model used to predict TB in diabetic individuals. The total sample in this study …

Smoking Habit At Home And Upper Respiratory Infection In Infants Aged 6-12 Months, Musfardi Rustam, Nur Pelita Sembiring, Taswir Effendy

Kesmas

Upper Respiratory Tract Infection (URI) is an acute infection caused by viruses, fungi, and bacteria. Smoking habit at home is a risk factor for URI in infants. This study aimed to determine a relationship between smoking at home and the incidence of URI in infants. This study was conducted the fourth week of February 2010 until the third week of April 2010 in Kampar District, Indonesia. This analytical study used a case-control design and cluster random sampling. The samples comprised 162 cases and 162 controls, infants aged 6-12 months. The cases were 162 infants aged 6-12 months suffering from URI …

Adverse Childhood Experiences, Perceived Socioeconomic Status And Resilience: Health Consequences In Young Adults, Akruti Patel

ETD Collection

Vulnerability to trauma, depression, and chronic conditions in adulthood increases with exposure to early life adversity (ACEs) during childhood. This study investigated the effect of adverse early childhood experiences has on depressive symptoms (measured using the Center for Epidemiologic Studies Depression Screening scale -CESD), somatic symptoms (measured using Cohen- Hoberman Inventory of Physical symptoms scale- CHIPS), resilience (measured using the Brief Resilience Scale- BRS), and young adult health-related quality-of-life (measured using Health Related Quality of Life scale- HRQOL) among a diverse sample of young adults (average age 27 years old). A diverse sample of 341 participants were recruited for the …

Empowering Patient Care Technicians To Reduce Non-Ventilated Hospital-Acquired Pneumonia In An Acute Care Hospital In Northern California, Barbra Pacatang

Master's Projects and Capstones

Abstract

Problem: Non-ventilator hospital-acquired pneumonia (nv-HAP) is increasingly becoming a significant concern in healthcare settings. Studies have indicated that nv-HAP accounts for a substantial portion of hospital-acquired pneumonia cases, with a high associated mortality rate. The prevalence of nv-HAP underscores the importance of implementing robust HAP prevention bundles. Prevention, early recognition, and appropriate management of nv-HAP are essential to improve patient outcomes and reduce the burden on healthcare facilities.

Context: A 28-bed capacity Stroke Telemetry Unit incurred six nv-HAP incidents in 2023. Patients needed to be more compliant with the nv-HAP prevention bundles. Patient care technicians (PCTs) are instrumental nurses’ …

Adaptive Immune Profiling Of Sin Nombre Hantavirus And Severe Acute Respiratory Syndrome Coronavirus 2 Infection, Tonilynn M. Baranowski

Biomedical Sciences ETDs

Hantaviruses are causative agents of potentially fatal respiratory illness and/or organ failure in humans worldwide. In the United States, the predominant hantavirus species, Sin Nombre hantavirus (SNV), causes a severe disease pathology, called hantavirus cardiopulmonary syndrome (HCPS). Infection with SNV and subsequent clinical manifestations of HCPS lends itself to case fatality rates approaching 40%, even under supportive care. This is partially due to the lack of FDA-approved vaccines and antivirals, in addition to a deficit in our knowledge regarding the human immune response to SNV. Further investigation of the adaptive immune response may reveal key targets to mediate disease outcome. …

A Quality Improvement Project: Implementing A Mental Health Screening Program For International Business Travelers., Joyce Ighedosa

Doctor of Nursing Practice Final Project Abstract

A Quality Improvement Project: Implementing a Mental Health Screening Program for International Business Travelers.

PURPOSE The purpose of the Quality Improvement project was to implement a mental health screening program for international business travelers in an oil and gas organization. The Patient Health Questionnaire (PHQ-2) was implemented

BACKGROUND The project was implemented in a global oil and gas organization. The original medical screening for pre-travel preparation was on identification of physiological disorders, proper management of identified disease processes; infectious disease prevention; vaccine review and update; malaria chemoprophylaxis and vector control. Mental Health was not reviewed.

METHODOLOGY The PHQ-2 was …

Pins, Inhwan Jeon

Theses

Pins aims to portray the societal landscape observed and experienced by me as an international student, highlighting sociological concerns like hatred and hate crimes instead of focusing on surface-level metrics such as the risk and fatality rates of COVID-19. Through this work, I want to remind the audience of the multifaceted nature of society and the emotions evoked by COVID-19, prompting reflection on the role of art during times of crisis. While transforming my original medium of metal objects into an installation art format, I explored concepts such as spacing, installation, cognition, narrative, and multiple senses. I integrated these elements …

Gemykibivirus Detection In Acute Encephalitis Patients From Nepal, Eans Tara Tuladhar, Smita Shrestha, Susan Vernon, Lindsay Droit, Kathie A Mihindukulasuriya, Mamta Tamang, Lata Karki, Annie Elong Ngono, Bimlesh Jha, Bal Krishna Awal, Bimal Sharma Chalise, Runa Jha, Sujan Shresta, David Wang, Krishna Das Manandhar

2020-Current year OA Pubs

UNLABELLED: Acute encephalitis syndrome (AES) causes significant morbidity and mortality worldwide. In Nepal, Japanese encephalitis virus (JEV) accounts for ~5-20% of AES cases, but ~75% of AES cases are of unknown etiology. We identified a gemykibivirus in CSF collected in 2020 from an 8-year-old male patient with AES using metagenomic next-generation sequencing. Gemykibiviruses are single stranded, circular DNA viruses in the family

IMPORTANCE: Viral encephalitis is a devastating disease, but unfortunately, worldwide, the causative virus in many cases is unknown. Therefore, it is important to identify viruses that could be responsible for cases of human encephalitis. Here, using metagenomic sequencing …